Title On Etiology and Pathophysiology of Acute Pancreatitis

Title
Author(s)
Citation
Issue Date
URL
On Etiology and Pathophysiology of Acute Pancreatitis :
WITH SPECIAL REFERENCE TO PARTICIPATION OF
PHOSPHOLIPASE A
HATAO, MASAHIKO
日本外科宝函 (1969), 38(1): 76-106
1969-01-01
http://hdl.handle.net/2433/207532
Right
Type
Textversion
Departmental Bulletin Paper
publisher
Kyoto University
9
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o
, Membranous components o
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c
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r membrane i
s mainlycomposed o
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h
o
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p
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d
, and i
ti
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a
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ys
u
p
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o
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n normal f
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ft
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r membrane i
sa
f
f
e
c
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e
d by
p
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o
s
p
h
o
l
i
p
a
s
e
.
I
na
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
,v
a
r
i
o
u
s enzymes a
r
ea
c
t
i
v
叫 e
do
rm
o
b
i
l
i
z
e
dt
ot
h
e whole body
w
i
t
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e
s
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l
t
i
n
gv
a
r
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o
u
ss
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h
a
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n
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l
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c
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lsymptomso
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h
i
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i
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e
a
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e
. P
h
o
s
p
h
o
l
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p
a
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e
A, one o
ft
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a
n
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t
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y
m
e
s
,h
a
s been c
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i
d
e
r
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dt
oe
x
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s
t most a
b
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n
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a
n
t
l
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nt
h
e
p
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n
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a
s
3
0
> and t
ob
ep
o
s
s
e
s
s
e
do
fs
t
r
o
n
gt
o
x
i
c
i
t
y
. However,fews
t
u
d
i
e
s have been made
on t
h
ea
t
t
i
t
u
d
e and p
a
t
h
o
p
h
y
s
i
o
l
o
g
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cr
o
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eo
fp
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p
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p
a
s
eA i
na
c
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t
ep
a
n
c
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e
a
t
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t
i
s
. I
n
1
9
6
1
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r
n
v
E
9
8
>o
b
s
e
r
v
e
d an i
n
c
r
e
a
s
ei
np
h
o
s
p
h
o
l
i
p
a
s
eAi
np
e
r
i
p
h
e
r
a
lb
l
o
o
do
fp
a
t
i
e
n
t
s
w
i
t
ha
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
, and p
o
s
t
u
l
a
t
e
dd
i
a
g
n
o
s
t
i
cs
i
g
n
i
f
i
c
a
n
c
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fd
e
t
e
r
m
i
n
a
t
i
o
no
fp
h
o
s
p
h
o
l
i
p
a
s
e A. CREUTZFELDT13> a
l
s
or
e
p
o
r
t
e
di
n1
9
6
6t
h
a
tf
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l
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n
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ta
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ep
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l
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e
e
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t
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l
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c
e
d by i
n
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s
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o
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h
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no
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p
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e A and
c
h
o
l
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ca
c
i
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n
t
ot
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ep
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n
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t
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c
t
, andhep
o
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e
do
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tt
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ei
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p
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t
a
n
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o
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p
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e
Ai
ne
t
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o
l
o
g
yo
fa
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
. Concerning t
h
er
o
l
eo
fp
h
o
s
p
h
o
l
i
p
a
s
eA i
na
c
u
t
e
p
a
n
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r
e
a
t
i
t
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s
, however, o
n
l
y afew s
t
u
d
i
e
s have b
e
e
nr
e
p
r
o
t
e
d
.
78
日 ・ 外 ・ 宝 第3
8巻 第 1号 （ 昭 和4
4
年 1月
〕
I
n
d
e
p
e
n
d
e
n
t
l
y fromt
h
e
s
es
t
u
d
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e
s
,i
no
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n
i
c
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g
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n
a
t
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n
gfrom t
h
es
t
u
d
y on p
h
o
s
p
h
o
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i
p
a
s
eC a
ti
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u
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t
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o
no
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e
p
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t
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ca
r
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r
y
9
6
>
,s
t
u
d
i
e
s have beenc
a
r
r
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e
do
u
t ont
h
e
s
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c
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nじeo
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eC i
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t
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t
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e
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0
>
. I
nt
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ep
r
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s
e
n
te
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t
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n
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n
v
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ep
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eA,one o
ft
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n
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a
t
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ce
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e
s
,
i
twast
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r’
which i
sc
o
n
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dp
r
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m
a
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yt
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e
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p
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t
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o
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y
and p
a
t
h
o
p
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s
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o
l
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g
yo
fa
c
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t
ep
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n
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a
t
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s
. I
nt
h
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m
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c
t
i
Y
i
t
yo
fp
h
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p
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n
d
i
t
sf
l
u
c
t
u
a
t
i
o
n werei
n
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t
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g
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t
e
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i
t
ht
h
el
a
p
s
eo
ft
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m
ei
nt
h
ep
a
n
c
r
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s
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r
,p
o
r
t
a
lb
l
o
o
d
,
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e
r
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p
h
e
r
a
lb
l
o
o
d and p
e
r
i
t
o
n
e
a
lf
l
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i
do
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o
g
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i
t
he
x
p
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m
e
n
t
a
l
l
yp
r
o
d
u
c
e
da
c
u
t
ep
a
n
c
r
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a
t
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t
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s
. M
o
r
e
o
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r
,p
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o
s
p
h
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l
i
p
a
s
eA, e
x
t
r
a
c
t
e
dfromt
h
eb
o
v
i
n
ep
a
n
c
r
e
a
s
, was i
n
f
u
s
e
di
n
t
o
t
h
ep
o
r
t
a
lv
e
i
no
rr
e
t
r
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p
e
r
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o
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e
a
ls
p
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c
ei
no
r
d
e
rt
oi
n
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s
t
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g
a
t
et
h
ei
n
f
l
u
e
n
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h
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s
p
h
o
l
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p
a
s
e A on o
r
g
a
n
i
s
m
. S
t
u
d
i
e
s weref
u
r
t
h
e
rc
a
r
r
i
e
do
u
tont
h
es
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g
n
i
f
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c
a
n
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h
o
s
p
h
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l
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p
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e
Ai
ne
t
i
o
l
o
g
i
cp
r
o
c
e
s
so
fa
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
.
I
I
.
MATERIALSANDMETHODS
1
. E
x
p
e
r
i
m
e
n
t
a
l Animal
H
e
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l
t
h
ya
d
u
l
t mongrel d
o
g
so
fb
o
t
hs
e
x
e
s weighingfrom 6 t
o1
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s
e
d
.
2
. Measurement o
fA
r
t
e
r
i
a
l and P
o
r
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a
lP
r
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s
s
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r
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Formeasuremento
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r
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lp
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x
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e
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. P
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s
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q
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s manometer c
o
n
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t
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h av
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3
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x
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fP
h
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p
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p
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eA
P
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e入 wase
x
t
r
a
c
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df
o
l
l
o
w
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n
gt
h
emethodo
fRrMON and S
H
A
P
I
R
0
7
9
>f
r
o
m
t
h
eb
o
v
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ep
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a
s
, which had b
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m
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r
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st
os
e
p
a
r
a
t
et
h
es
e
d
i
m
e
n
t
. Thes
e
d
i
m
e
n
twasd
i
s
s
o
l
v
e
di
no
~hosphate b
t
出e
ro
f pH 7
.0 (
p
r
e
p
a
r
a
t
i
o
n IV
・
） The o
b
t
a
i
n
e
dp
r
e
p
a
r
a
t
i
o
n IV m
a
n
i
f
e
s
t
s
d
e
c
o
m
p
o
s
i
t
i
o
nc
a
p
a
c
i
t
yo
fo
v
o
l
e
c
i
t
h
i
no
f0
.0324μ moles/mgm
i
n
.i
n 2 :4 :6 c
o
l
l
i
d
i
n
e
r
e
p
a
r
a
t
i
o
n IV was u
s
e
da
sp
h
o
s
p
h
o
l
i
p
脱
Ai
nt
h
ep悶 n
t目
b
u
f
f
e
ra
t 30°C6n ~his p
p
e
r
i
m
e
n
t
. The p
r
o
t
e
mc
o
n
t
e
n
t wasd
e
t
e
r
m
i
n
e
df
o
l
l
o
w
i
n
gt
h
e method o
f LOWRY56)
4
. P
r
o
d
u
c
t
i
o
no
f AcuteP
a
n
c
r
e
a
t
i
t
i
si
n Animals
Dogs were a
n
e
s
t
h
e
t
i
z
e
dw
i
t
hi
n
t
r
a
v
e
n
o
u
sa
d
m
i
n
i
s
t
r
a
t
i
o
no
f Nembutalo
f 25mg/kg
ONETIOLOGYANDPATHOPHYSIOLOGYOFACUTEPANCREATITIS
7り
body w
e
i
g
h
t
. Theabdomenwasopenedbyu
p
p
e
rm
i
d
l
i
n
ei
n
c
i
s
i
o
n
. The a
c
c
e
s
s
o
r
yp
a
n
c
r
e
a
t
i
cd
u
c
t was l
i
g
a
t
e
d and t
h
e main p
a
n
c
r
e
a
t
i
cd
u
c
t was e
x
p
o
s
e
d
,i
n
t
o which p
a
n
c
r
e
a
t
i
t
i
s
p
r
o
d
u
c
i
n
ga
g
e
n
t
swereg
e
n
t
l
yi
n
f
u
s
e
d
. Then t
h
e main p
a
n
c
r
e
a
t
i
cd
u
c
t was d
o
u
b
l
yl
i
g
a
t
e
d
andc
u
t
. As p
a
n
c
r
e
a
t
i
t
i
sp
r
o
d
u
c
i
n
ga
g
e
n
t
,0
.3cc/kg bodyw
e
i
g
h
to
fa
u
t
o
g
e
n
o
u
sb
i
l
e was
u
s
e
df
o
ri
n
v
e
s
t
i
g
a
t
i
o
no
ff
l
u
c
t
u
a
t
i
o
ni
np
h
o
s
p
h
o
l
i
p
a
s
eA a
c
t
i
v
i
t
y
. At t
h
e same t
i
m
e
,p
h
o
s
p
h
o
l
i
p
a
s
eA s
u
s
p
e
n
s
i
o
no
f 10mg/cc, e
x
t
r
a
c
t
e
dfromb
o
v
i
n
ep
a
n
c
r
e
a
s
,was i
n
f
u
s
e
di
n
t
ot
h
e
main p
a
n
c
r
e
a
t
i
cd
u
c
ti
nv
a
r
i
o
u
sd
o
s
e
sw
i
t
h sodium d
e
o
x
y
c
h
o
l
a
t
ei
no
r
d
e
rt
oe
x
p
l
o
r
et
h
e
a
p
p
e
a
r
a
n
c
eo
fo
n
s
e
to
fa
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
. For t
h
ec
o
n
t
r
o
ls
t
u
d
y
,f
a
l
s
el
a
p
a
r
o
t
o
m
y was
performed and t
h
e panじr
e
a
t
i
cd
u
c
t was e
x
p
o
s
e
d and b
i
l
ev
v
a
sd
i
s
c
a
r
d
e
d
.
5
. D
e
t
e
r
m
i
n
a
t
i
o
no
fP
h
o
s
p
h
o
l
i
p
a
s
eA A
c
t
i
v
i
t
y
i
. P
u
r
i
f
i
c
a
t
i
o
no
fS
u
b
s
t
r
a
t
e(
L
e
c
i
t
h
i
n
)
O
v
o
l
e
c
i
t
h
i
n was e
x
t
r
a
c
t
e
d and p
u
r
i
f
i
e
d from f
r
e
s
hy
o
l
kf
o
l
l
o
w
i
n
gt
h
e method o
f
PANGBORN72> which was u
s
e
df
o
rs
u
b
s
t
r
a
t
e
. Yolk was t
r
e
a
t
e
dw
i
t
ha
c
e
t
o
n and added
w
i
t
h 95 p
e
rc
e
n
te
t
h
a
n
o
l
, which was t
h
e
nv
i
g
o
r
o
u
s
l
y shaken and f
i
l
t
e
r
e
d by a
s
p
i
r
a
t
i
o
n
.
S
o
l
u
t
i
o
no
f CdCl2 was added t
ot
h
ef
i
l
t
r
a
t
e and p
r
e
c
i
p
i
t
a
t
i
o
no
fl
e
c
i
t
h
i
n
C
c
l
C
I
, was p
u
r
i
f
i
e
dw
i
t
hc
h
l
o
r
o
f
o
r
m
,e
t
h
a
n
o
l and p
e
t
r
o
l
e
u
me
t
h
e
r
, which was f
u
r
t
h
e
rd
i
s
s
o
l
v
e
di
nc
h
l
o
r
o
form and v
i
g
o
r
o
u
s
l
y shaken w
i
t
h 30 p
e
rc
e
n
ta
l
c
o
h
o
lt
od
i
s
s
o
c
i
a
t
el
e
c
i
t
h
i
n from CdCl2
compound. The p
r
e
c
i
p
i
t
a
t
i
o
n was d
r
i
e
dunder d
e
c
o
m
p
r
e
s
s
i
o
n
. The o
b
t
a
i
n
e
dl
e
c
i
t
h
i
n was
d
i
s
s
o
l
v
e
di
n anhydrous e
t
h
e
r and f
i
l
t
e
r
e
d by BUCHNER’
sf
u
n
n
e
l
. By t
h
i
sp
r
o
c
e
d
u
r
e
,f
l
o
e
c
u
l
e
n
tp
r
e
c
i
p
i
t
a
t
ec
o
u
l
db
er
e
m
o
v
e
d
. Remaining c
l
e
a
rf
i
l
t
r
a
t
e was d
r
i
e
d under vacuum.
Thus, f
i
n
a
l
l
yp
u
r
i
f
i
e
dl
e
c
i
t
h
i
n was o
b
t
a
i
n
e
d
,which wass
t
o
r
e
di
nr
e
f
r
i
g
e
r
a
t
e
rb
e
i
n
gs
o
l
v
e
d
i
n as
m
a
l
l amount o
fa
b
s
o
l
u
t
ea
l
c
o
h
o
lu
n
t
i
lu
s
e
d
. Q
u
a
n
t
i
t
a
t
i
v
ed
e
t
e
r
m
i
n
a
t
i
o
no
fl
e
c
i
t
h
i
n
was done t
h
r
o
u
g
hd
e
t
e
r
m
i
n
a
t
i
o
no
fp
h
o
s
p
h
o
r
u
s2
7
>
.
i
i
. Sample (
S
o
u
r
c
eo
fP
h
o
s
p
h
o
l
i
p
a
s
e A)
P
a
n
c
r
e
a
t
i
ct
i
s
s
u
e
,h
e
p
a
t
i
ct
i
s
s
u
e
,p
o
r
t
a
lb
l
o
o
d
,p
e
r
i
p
h
e
r
a
lb
l
o
o
d and p
e
r
i
t
o
n
e
a
lf
l
u
i
d
werec
o
l
l
e
c
t
e
d frome
x
p
e
r
i
m
e
n
t
a
la
n
i
m
a
l
sb
e
f
o
r
et
h
ep
r
o
d
u
c
t
i
o
no
fa
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
,6
,
1
2
, 1
8
, ~4, 48 and 72 h
o
u
r
sa
f
t
e
rt
h
ep
r
o
d
u
c
t
i
o
no
fa
c
u
t
ep
a
n
c
r
e
a
t
i
t
i
s
,and p
h
o
s
p
h
o
l
i
p
a
s
e
Aa
c
t
i
v
i
t
y was d
e
t
e
r
m
i
n
e
di
ne
a
c
hs
a
m
p
l
e
,r
e
g
a
r
d
i
n
gthema
se
n
z
y
m
a
t
i
cs
o
u
r
c
e
. P
a
n
c
r
e
a
t
i
c
s
a
m
p
l
e was t
a
k
e
n from t
h
ei
n
f
e
r
i
o
r arm o
ft
h
ep
a
n
c
r
e
a
si
n as
m
a
l
ls
e
c
t
i
o
n and u
s
e
di
n
a 10 p
e
rc
e
n
th
o
m
o
g
e
n
a
t
e
. L
i
v
e
rsample was t
a
k
e
nfromt
h
el
e
f
ti
n
f
e
r
i
o
rl
o
b
e and u
s
e
d
i
n a33 p
e
rc
e
n
th
o
m
o
g
e
n
a
t
e
. P
o
r
t
a
lb
l
o
o
dwasc
o
l
l
e
c
t
e
dd
i
r
e
c
t
l
y from t
h
ep
o
r
t
a
lv
e
i
ni
n
t
h
el
i
v
e
rh
i
l
u
m
, andp
e
r
i
p
h
e
r
a
lb
l
o
o
d was c
o
l
l
e
c
t
e
d fromt
h
ef
e
m
o
r
a
lv
e
i
n
,b
o
t
ho
ft
h
e
s
e
b
e
i
n
gi
m
m
e
d
i
a
t
e
l
yu
s
e
da
f
t
e
rs
e
p
a
r
a
t
i
o
no
fs
e
r
u
m
. P
e
r
i
t
o
n
e
a
lf
l
u
i
d was c
o
l
l
e
c
t
e
dd
i
r
e
c
t
l
y
around t
h
e duodenum.
i
i
i
. I
n
c
u
b
a
t
i
o
n System
F
o
l
l
o
w
i
n
gt
h
emethod o
fZ
I
E
V
E
9
8
>
, enzyme s
o
u
r
c
eo
f1
.0c
c was added t
o0
.05M
.0c
cw
i
t
h pH8
.4
5
, which was p
r
e
h
e
a
t
e
df
o
r30m
i
n
u
t
e
sa
t55°C. The
b
o
r
a
t
eb
u
f
f
e
ro
f1
m
i
x
t
u
r
e wasadded t
o 30μM o
fs
u
b
s
t
r
a
t
e(
o
v
o
l
e
c
i
t
h
i
n
) and 20mg o
fd
e
o
x
y
c
h
o
l
a
t
es
u
s
pended i
n 4c
co
f0
.OSM b
o
r
a
t
eb
u
f
f
e
r
,andt
h
i
swasi
n
c
u
b
a
t
e
df
o
rc
e
r
t
a
i
nl
e
n
g
t
ho
ft
i
m
e
a
t 55°C. D
u
r
a
t
i
o
no
ft
h
ei
n
c
u
b
a
t
i
o
nd
i
f
f
e
r
e
d dependingon t
h
es
o
u
r
c
eo
f enzyme, i
tb
e
i
n
g 60 m
i
n
u
t
e
sf
o
rp
a
n
c
r
e
a
t
i
cs
a
m
p
l
e
, 180m
i
n
u
t
e
sf
o
rh
e
p
a
t
i
cs
a
m
p
l
e and p
e
r
i
t
o
n
e
a
lf
l
u
i
d
and 1
8h
o
u
r
sf
o
rs
e
r
u
m
.
P
h
o
s
p
h
o
l
i
p
a
s
eA a
c
t
i
v
i
t
y was d
e
t
e
r
m
i
n
e
d fromt
h
ed
e
c
r
e
a
s
ei
na
c
y
le
s
t
e
r bond which
i
sp
r
o
d
u
c
e
da
sar
e
s
u
l
to
ft
h
ep
r
o
c
e
s
so
fi
n
c
u
b
a
t
i
o
ni
nwhich s
u
b
s
t
r
a
t
el
e
c
i
t
h
i
ni
s decomposed
日 ・ 外 ・ 宝 第3
8巻 第 1号 （ 昭 和44年 1月
）
80
andc
o
n
v
e
r
t
e
dt
ol
y
s
o
l
e
c
i
t
h
i
n
.
i
v
. Acy! E
s
t
e
rC
o
n
t
e
n
t
Acy! e
s
t
e
rc
o
n
t
e
n
twasd
e
t
e
r
m
i
n
e
df
o
l
l
o
w
i
n
gt
h
ehydroxamic a
c
i
d methodo
fSTERN
andSHAPIR086J.
v
. U
n
i
t
An amount o
fp
h
o
s
p
h
o
l
i
p
a
s
e A which decomposes 0
.0
0
0
1
1
_
1
,
Mo
fs
u
b
s
t
r
a
t
ep
e
r1
m
i
n
u
t
e was e
x
p
r
e
s
s
e
da
s 1u
n
i
t
.
I
I
I
. RESULTS
A. Changes o
fP
h
o
s
p
h
o
l
i
p
s
eA A
c
t
i
v
i
t
yi
n Dogs w
i
t
h Acute B
i
l
i
a
r
yP
a
n
c
r
e
a
t
i
t
i
s
T
a
b
.1
. P
h
o
s
p
h
o
l
i
p
a
s
eA A
c
t
i
v
i
t
y(
u
n
i
t
s
/
g
)w
i
t
h
i
nP
a
n
c
r
e
a
s
Dogs w
i
t
hAcuteP
a
n
c
r
e
a
t
i
t
i
s
品叩
−4A
一凡
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、
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パリ
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a
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t
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e
r
s
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t
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e
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c
t lympht
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p
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l
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n
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r
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a
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from 1t
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e
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t
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n
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a
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a
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o
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r
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t
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o 20h
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r
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rt
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o
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ys
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o
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c
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t
ep
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t
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o
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c
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t
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t
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o
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t
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n
z
y
m
e
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p
a
r
t
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c
u
l
a
r
l
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h
a
to
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s
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nh
a
s beenc
o
n
s
i
d
e
r
e
dt
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ee
s
s
e
n
t
i
a
l
,and t
h
es
t
u
d
i
e
s havebeen
w
i
d
e
l
yc
a
r
r
i
e
do
u
ton t
h
i
sr
e
s
p
e
c
t
. Numerous s
t
u
d
i
e
s have b
e
e
nr
e
p
o
r
t
e
dd
e
m
o
n
s
t
r
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o
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n
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r
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c
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e
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o
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r and h
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h
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d
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l
l
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n
et
r
y
p
s
i
n
,
96
巻 第 l号
8
1・外・ 宝 第 3
1
昭和4l年
I
(
1月）
dea
h
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e
t
i
b
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n
, however, i
s
a
, which w
r
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i
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n
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y
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c
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e
t
r
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A
. IsmKAw
s
a
e
r
c
n
a
ep
h
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i民主 o
u
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a
g
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e and v
t
c homogena
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no
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r
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h
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et
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s. IsmKAWA50l,
i
t
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t
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e
r
c
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ep
t
u
c
ta
y onorganisma
bl
a
r
o
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l
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n
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s
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n
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ep
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m
u
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s
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o
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hebody a
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nt
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h
From t
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s
o pho
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n
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r
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o
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h
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n
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a
r
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o
s
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h
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l
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p
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s
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n
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u
s
e
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n
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n
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cd
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c
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e
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y
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h
o
l
a
t
e
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n
c
r
e
a
t
i
t
i
so
fv
a
r
i
o
u
sd
e
g
r
e
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o
u
l
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s
e
r
v
e
d
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h
e amount o
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n
f
u
s
e
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h
o
s
p
h
o
l
i
p
a
s
e A.
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h
e
s
ef
i
n
d
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n
g
s
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ti
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h
a
ta
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h
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h
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l
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p
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s
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nt
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ep
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t
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）
年 1月
巻 第 l号 （ 昭 和」l
8
J ・外・宝第 3
I
6
0
1
和文抄録
急性牌炎の 病因及び病 態生理
殊に
phospholipase A
京都大学医宇部外科
の関与 について
指導：；本庄一夫教授）
,1講座 （
f
)
畑
尾
正
従来より，急性勝炎の病因あるいは病態生理が論ぜ
，
と
l
彦
eA
s
a
p
i
l
o
h
p
s
o
h
日脈血，末梢血，腹腔液中の p
,F
I
H
nが演ずる役割の
i
,
ryp
乙t
，蛋自分解酵素殊l
1
られ ゐ以 ：
は，門脈血において最
ど
；
＇
.
活性も克進し，その冗進のね I
極めて重要なこと は，一般に広く認められているとこ
dskは
i
o
p
i
nが l
i
,
p
tは tn・
d
e
t
ろである．一方， Drags
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lによ り川成さ
a
i
r
e
t
a
dm
i
o
p
i
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川口を中心とせる概念に
ryp
れていることから，乙の t
認められ，これは門脈血及び肝において最も明瞭であ
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った．
eA 活性の充進せるも
s
a
p
i
l
o
h
p
s
) 早期に強く pho
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, Beck らは胆汁性勝炎における勝組織 Fi~ ま
k
c
a
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r
e
v
Ha
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a
p
i
l
o
h
p
s
o
h
3〕 p
ζ
n活性を認めず，更に形態学的l
i
s
たは勝液中lζtryp
l著明の動脈庄下降が認められた
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l
ζ注入すると一過性
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kI
c
o
h
ま s
正常域に復しそのま
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n によるそれとは異なっている
i
s
ηp
も胆汁性勝炎は t
<管内活入が必
;
i
J
ll のI
I
r、p、
ことが指摘され，また活性 t
n一辺倒の考え方
i
s
p
y
r
ずしも隣炎を惹起しないなど， t
c対する批判も少なくない．
t
乙
石川は，犬の実験 的急性体駿死にお いて，肝内 l
eぐ活性が元進して致死的因子となり得る
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a
p
i
l
o
h
p
s
o
h
p
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l fa c t< •r と等しく
a
h
t
e
乙の l
ることはなかった． 大腿静脈内注入犬は，その後元気
時間
0
C回復，生存 したか，門脈内注入犬は注入後約 2
I
ζ 強い変化が認められ た．
で死亡した．剖検で肝l
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s
a
p
i
ol
ph
s
) pho
l
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ろ，注入後 2時闘の観察では殆んど血圧の変動を示さ
時間後には. 3頭の実験犬のうち 2
なかったが，約20
eλ の豊富に存
as
p
i
l
o
h
p
s
乙作用する pho
dl
i
p
i
l
o
h
p
s
o
h
p
ζ著変を認
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ar
と か，B
l
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li
o
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n
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n
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d
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v
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r
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c
n
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g
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s
a
p
i
ol
h
p
s
o
h
5) p
eとともに注入せるとこ ろ，注
t
a
l
o
h
c
y
ox
odiumde
l，s
ζ
s らによって明らかにされている ．
n
o
b
b
i
G
急性腺炎の際，各慈の！洋酵素が活性化され閥質内に
伴炎の発生せる乙とが認め
ζ応じて種々のも：肢の 1
入量l
ζ
逸脱して化学的自己融解現象を招き，あるいは全身l
くり，予後に
l
拡がって，この疾病ζ特有の病像を形づ
・
i
l
o
h
p
s
o
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ζ 際してj
以上，急性勝炎i
，あるいは
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l
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e.
s
a
p
、
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s
a
p
i
l
o
h
p
s
後腹膜に pho
，豊富に存在 し．しかも強い毒性を有する ものであ
jミ
ζ 関しては， ζれ
l
λ
e
s
a
p
i
l
o
h
p
s
o
h
るといわれながら p
潤すると，生体は重大な悪影響をこうむるものである
i
l
o
h
p
s
o
h
と考えられる．また，勝炎発生機序の上でも p
まで，あまりかえりみられていなかった．今回の実験
e
s
a
ip
l
o
h
p
s
o
汁性の急性隣炎を作成して， ph
!
E
H
では，犬！ C
P• "t' λ （工大き な役割を架しているものと考えられ る ．
ζ及
A活性の動態を検索 し，更にこの酵素の直接生体l
.
:
t
!
.
i
［ます影響についても検討を飢 え ，次の結＇~＇.；；；＼；'
λ
e
s
a
p
i
l
o
h
p
陥 ζ極めて高い phos
1) 正常の犬でも， l
られた．
今回の実験で明らかにされた如く ，急性肺炎の病因
ζ優
nl
i
s
p
y
r
eA は t
s
a
p
i
ol
h
p
s
o
h
及び病態生理の上で p
活性が認め られた． 急性勝炎を作成すると， ζ の脈内
ると も劣らぬ重要な役割を演じているものであ り，従
nを中心とせる概念のみにては説明し得なか
i
s
r、p
米 t
ζ，ある 限度の解明を与えるも
つかの間題点l
く
ったい
eA 活性は更に冗進した か． それと同時
s
a
p
i
l
o
h
p
s
pho
のといえよう．