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石黒浩二 , 吉元 誠, 田仁人*, 高垣Q也*

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石黒浩二 , 吉元 誠, 田仁人*, 高垣Q也*
E 45 F
Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No. +, ./D.3 (,**1) G×ɔC‘H
45
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Hypotensive E#ect of Sweetpotato Tops
Koji IshiguroL, Makoto Yoshimoto, Masahito Tsubata*
and Kinya Takagaki*
National Agricultural Research Center for Kyushu
Okinawa Region, 00/+B, Yokoichi,
Miyakonojo, Miyazaki 22/B**3+
* Toyoshinyaku, Co., Ltd., 1B,2 Yayoigaoka,
Tosu, Saga 2.+B***/
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Sweetpotato tops exhibited angiotensin I-converting
enzyme (ACE) inhibitory activity, with di#erent levels
of activity in the constituent parts of the tops. Leaves
showed the highest activity, while that of stems and
petioles was much reduced. Since there appeared to be a
relationship between ACE inhibitory activity and the
total content of the ca#eoylquinic acids in the constituent
parts, the ACE inhibitory activity of each ca#eoylquinic
acid was analyzed. -,.,/-tri-O-ca#eoylquinic acid (-,.,/triCQA) showed the strongest activity, followed by -,.di-O-ca#eoylquinic acid (-,.-diCQA), and .,/-di-O-ca#eoylquinic acid (.,/-diCQA). Spontaneously hypertensive
rats (SHR) which were orally administered sweetpotato
tops exhibited dose-dependent suppression in blood pressure increases in comparison with the control group.
These results suggest that sweetpotato tops have a
hypotensive e#ect in SHR, which is at least in part due to
the ACE inhibitory activity of ca#eoylquinic acids.
(Received Aug. ,/, ,**0 ; Accepted Oct. +-, ,**0)
Keywords : sweetpotato tops, Suioh, angiotensin I-converting
enzyme (ACE) inhibitory activity, spontaneously
hypertensive rats (SHR), ca#eoylquinic acids
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.E Islam, M.S., Yoshimoto, M., Yahara, S., Okuno, S.,
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2E °®«[email protected] M¢UD÷@ T£¯õ@ yø„‰¿@ }„’u
–uGšbmp’v€•˜ŠC’î c•˜ˆ^]µ
[@ S´ß@ [email protected] -+-C-+1 D+330EA
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