石黒浩二 , 吉元 誠, 田仁人*, 高垣Q也*

E 45 F
Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No. +, ./D.3 (,**1) G×ɔC‘H
45
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Hypotensive E#ect of Sweetpotato Tops
Koji IshiguroL, Makoto Yoshimoto, Masahito Tsubata*
and Kinya Takagaki*
National Agricultural Research Center for Kyushu
Okinawa Region, 00/+B, Yokoichi,
Miyakonojo, Miyazaki 22/B**3+
* Toyoshinyaku, Co., Ltd., 1B,2 Yayoigaoka,
Tosu, Saga 2.+B***/
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Sweetpotato tops exhibited angiotensin I-converting
enzyme (ACE) inhibitory activity, with di#erent levels
of activity in the constituent parts of the tops. Leaves
showed the highest activity, while that of stems and
petioles was much reduced. Since there appeared to be a
relationship between ACE inhibitory activity and the
total content of the ca#eoylquinic acids in the constituent
parts, the ACE inhibitory activity of each ca#eoylquinic
acid was analyzed. -,.,/-tri-O-ca#eoylquinic acid (-,.,/triCQA) showed the strongest activity, followed by -,.di-O-ca#eoylquinic acid (-,.-diCQA), and .,/-di-O-ca#eoylquinic acid (.,/-diCQA). Spontaneously hypertensive
rats (SHR) which were orally administered sweetpotato
tops exhibited dose-dependent suppression in blood pressure increases in comparison with the control group.
These results suggest that sweetpotato tops have a
hypotensive e#ect in SHR, which is at least in part due to
the ACE inhibitory activity of ca#eoylquinic acids.
(Received Aug. ,/, ,**0 ; Accepted Oct. +-, ,**0)
Keywords : sweetpotato tops, Suioh, angiotensin I-converting
enzyme (ACE) inhibitory activity, spontaneously
hypertensive rats (SHR), ca#eoylquinic acids
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-E Ishiguro, K., Toyama, J., Islam, M.S., Yoshimoto, M.,
Kumagai, T., Kai, Y., Nakazawa, Y. and Yamakawa, O.,
Suioh, a new sweetpotato cultivar for utilization in
vegetable greens. Acta Hort., 0-1, --3C-./ D,**.EA
.E Islam, M.S., Yoshimoto, M., Yahara, S., Okuno, S.,
Ishiguro, K. and Yamakawa, O., Identification and Characterization of foliar polyphenolic composition in
sweetpotato (Ipomoea batatas L.) genotypes. J. Agric.
Food Chem., /*, -1+2C-1,, D,**,EA
/E Islam, M.S., Yoshimoto, M. and Yamakawa, O., Distribution and physiological functions of ca#eoylquinic acid
derivatives in leaves of sweetpotato genotypes. J. Food
Sci., 02, +++C++0 D,**-EA
0E Yoshimoto, M., Yahara, S., Okuno, S., Islam, M.S., Ishiguro,
K. and Yamakawa, O., Antimutagenicity of mono-, di-,
and trica#eoylquinic acid derivatives islated from
sweetpotato (Ipomoea batatas L.) leaf. Biosci. Biotech.
Biochem., 00, ,--0C,-.+ D,**,EA
1E Yoshimoto, M., Kurata, R., Okuno, S., Ishiguro, K.,
Yamakawa, O., Tsubata, M., Mori, S. and Takagaki, K.,
Nutritional value and physiological functions of
sweetpotato leaves. Acta Hort., 1*-, +*1C++/ D,**0EA
2E °®«[email protected] M¢UD÷@ T£¯õ@ yø„‰¿@ }„’u
–uGšbmp’v€•˜ŠC’î c•˜ˆ^]µ
[@ S´ß@ [email protected] -+-C-+1 D+330EA
3E Mahmood, N., Moore, P.S., De Tommasi, N., De Simone,
F., Colman, S., Hay, A. J. and Pizza, C., Inhibition of HIV
infection by ca#eoylquinic acid derivatives. Antiviral
Chemistry and Chemotherapy, ., ,-/C,.* D+33-EA
+*E Peluso, G., De Feo, V., De Simone, F., Bresciano, E. and
Vuotto, M.L., Studies on the inhibitory e#ects of caffeoylquinic acids on monocyte migration and superoxide ion production. J. Nat. Prod., /2, 0-3C0.0 D+33/EA
++E Matsui, T., Ebuchi, S., Fujise, T., Abesundara, K. J.M.,
Doi, S., Yamada, H. and Matsumoto, K., Strong antihyperglycemic e#ects of water-solble fraction of Brazilian propolis and its bioactive constituent, -,.,/-tri-Oca#eoylquinic acid. Biol. Pharm. Bull., ,1, +131C+2*-
C 49 D
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Cheung, H.S. and Cushman, D.W. Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by
synthetic venom peptides of Bothrops Jararaca. Biochim.
Biophys. Acta., ,3-, ./[email protected] C+31-DA
+-D Œlµ¸@ ¥©KOP‚xk‰r±¬JGL‡³gV
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+/D Actis-Goretta, L., Ottaviani, J.I. and Fraga, C.G., Inhibition of angiotensin converting enzyme activity by
flavanol-rich foods. J. Agric. Food Chem., /., ,,[email protected],-.
C,**0DA
+,D
49
Mishima, S., Yoshida, C., Akino, S. and Sakamoto, T.,
Antihypertensive e#ects of Brazilian propolis : Identification of ca#eoylquinic acids as constituents involved
in the hypotension in spontaneously hypertensive rats.
Biol. Pharm. Bull., ,2, +3*[email protected]+3+. C,**/DA
+1D Ishiguro, K. and Yoshimoto, M., Content of an eyeprotective nutrient lutin in sweetpotato leaves. Acta
Hort., 1*-, ,/[email protected],/0 C,**0DA
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