気相移動度（菅井俊樹）

J. Mass Spectrom. Soc. Jpn.
Vol. 58, No. 2, 2010
REVIEW
6 Fundamentals of Mass Spectrometry
ῌIon Mobility Spectrometryῌ
Toshiki SJ<6>
Department of Chemistry, Toho University, Funabashi, CHIBA, JAPAN
Ion mobility spectrometry (IMS) has the same long history as mass spectrometry (MS). The method detects
charged molecules not in vacuum but in bu#er gas. Through the interaction between the charged molecules and
the bu#er gas, unique properties like structures, chiralities, and hydrophilicity of molecules can be observed by
IMS. However, the resolution and the sensitivity of IMS are far less than those of MS limiting the applications
of IMS. Those disadvantages have been resolved by the recent development of the ion and the vacuum handling
techniques, which leads to hybrid spectrometry of IMS/MS (ion mobility spectrometry/mass spectrometry).
Here we show the concept and recent progress on IMS, especially on IMS/MS, which have been opening new field
in nano, bio, and environment sciences.
(Received May 25, 2009; Accepted July 8, 2009)
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Correspondence to: Toshiki SJ<6>, Department of Chemistry, Toho University, Miyama 2῍2῍1, Funabashi, Chiba 274῍
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Keywords: Ion mobility spectrometry, Nano-science, Collision dynamics, Molecular interaction, Bio-science
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