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血球分離デバイス

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血球分離デバイス
1/6
研究概要
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
~微量血液から血液分析ができる装置開発を目指す~
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.血球/血漿分離技術
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
超微量血液検査プラットフォームシステム
© Konishi-Lab.
分岐流路 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
(二プロ、山科精器、旭光電機と共同開発)
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
流体力学的効果を応用して
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
血液を血球と血漿に分離を
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
行うデバイスの開発
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
フィルタ分離デバイス
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
膜フィルタを用いて
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
微量血液を血球と血漿に分離を
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
行うデバイスの開発
要素技術を
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
装置に統合
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
分注技術© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
超微量液滴分注デバイス
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
液体を目的の液量に
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
分けることができる
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
デバイスの開発
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Micro/Nano Mechatronics LAB.
Konishi LAB.
2/6
研究背景
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
従来の血液検査システム(血糖値などの各種成分の分析)
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
試薬と混合・血糖値
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
©
Konishi-Lab.
©
Konishi-Lab. © Konishi-Lab.
血球
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. ©
Konishi-Lab. © Konishi-Lab.
採血
分離
試薬と混合・コレステロール
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
血漿
分注
・
・
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
・
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
小型化・集積化
© Konishi-Lab. © Konishi-Lab. ©
Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
(Micro
Total Analysis
Systems)
© Konishi-Lab. © Konishi-Lab.分析部
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
混合部 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
廃液部
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © ◆分離部への要求項目
Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
試薬
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・短時間分離
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
・血漿の高回収率
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
注入口
・高純度の血漿回収
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. ©分離部
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
μ-TAS
Micro/Nano Mechatronics LAB.
Konishi LAB.
3/6
分岐流路を用いた分離原理
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Inlet © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
マイクロ領域では層流状態となり
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
粒子は流線に沿って流れる
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
主流路
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
粒子の重心位置が
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
Outlet
境界流線の外側:主流路のまま
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © 内側:枝流路へ
Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
枝流路 © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
血漿
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
血球
© Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. ©境界流線位置は
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Outlet
© Konishi-Lab. © Konishi-Lab. ©主流路と枝流路の流量比により調節可能
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. ©境界流線を操作することにより
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. ©分離能力の設定が可能
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Micro/Nano Mechatronics LAB.
Konishi LAB.
4/6
ブタ血液分離実験
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
◆流路構造の評価
©
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
Branched
© (分岐流路を多段に組むことで高純度の血漿を回収)
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Flow © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Inlet
Inlet© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
Main
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.
Flow
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab.Outlet
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
1
plasma1
Outlet
© Konishi-Lab. © Konishi-Lab. ©plasma
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Outlet
© Konishi-Lab. © Konishi-Lab.
© plasma
Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
plasma22
Outlet
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Outletcell1cell1 Outlet
Outlet
cell2 cell2
© Outlet
Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.分岐部における血球/血漿分離を確認
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Micro/Nano Mechatronics LAB.
Konishi LAB.
5/6
まとめと今後の展望
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
研究成果
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・分岐流路デバイスの開発
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・分岐流路を多段に組むことで高純度の血漿を回収
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
©更なる短時間分離・血漿の高回収率・高純度の血漿回収を目指す
Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
関連発表© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
◇ Kenichi Morimoto, Tatsuhiko Ito, Satoshi Konishi, “Multiarticular Actuator Composed of Serially Connected Micropistons
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
For Wearable Actuator”,
μTAS 2012., pp.551-.553
.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
◇ K. Morimoto, D. Kato & S. Konishi, “Numerical Estimation Of Plasma Layer Thickness In Branched Microchanel Using
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
A Multi - Layer Model
Of Blood Flow”μTAS
2010, pp.378-380 . © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Micro/Nano Mechatronics LAB.
Konishi LAB.
6/6
補足資料
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
用語説明© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・血液検査: 採取した血液を利用して、病状などを調べる臨床検査。
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・μTAS: Micro-Total
Analysis
Systemsの略。MEMS(微細加工)技術を用いて、チップ上に微小な
反応室、混合室を設け、一つのチップ上でさまざまな液体・気体を分析する。
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・層流状態: 管壁に近づくほど流速は小さくなり、管の中心で最も流速が大きくなる。
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
本研究を行う上で必要な知識
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・半導体工学(MEMS,微細加工技術)
© Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・流体力学
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
・生化学
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
© Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab. © Konishi-Lab.
Micro/Nano Mechatronics LAB.
Konishi LAB.
Fly UP