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ヒューマンエラー・交通事故を誘発する眠気の 発生要因と対策に関する
ヒューマンエラー・交通事故を誘発する眠気の 発生要因と対策に関する系統的研究 ― 平成 24 年度(本報告) タカタ財団助成研究論文 ― ISSN 2185-8950 研究代表者 駒田 陽子 研究実施メンバー 研究代表者 東京医科大学睡眠学講座・公益財団法人神経研究所 駒田 陽子 研究協力者 東京医科大学睡眠学講座・公益財団法人神経研究所 井上 雄一 東京医科大学睡眠学講座・公益財団法人神経研究所 浅岡 章一 東京医科大学睡眠学講座・公益財団法人神経研究所 中島 俊 東京医科大学睡眠学講座・公益財団法人神経研究所 笹井 妙子 東京医科大学睡眠学講座・公益財団法人神経研究所 中村 真樹 東京医科大学睡眠学講座・公益財団法人神経研究所 對木 悟 東京医科大学睡眠学講座・公益財団法人神経研究所 岡島 義 東京医科大学睡眠学講座・公益財団法人神経研究所 小林 美奈 ሗ࿌᭩ᴫせ ╀Ẽࡣ㸪ࣄ࣮࣐࢚࣮࣭ࣗࣥࣛ㏻ᨾࢆᘬࡁ㉳ࡇࡍせ࡞ཎᅉࡢ୍ࡘ࡛࠶ࡿ㸬╀Ẽࡸ ᮏࣉࣟࢪ࢙ࢡࢺࡣ㸪 ᒃ╀ࡾࡀཎᅉ࡛㉳ࡇࡿᨾࡣ㸪ࣈ࣮ࣞ࢟ࡸࣁࣥࢻࣝ᧯సࡼࡿ༴㝤ᅇ㑊⾜ືࡀࡽࢀࡎ㸪 㧗㏿ࡢࡲࡲᨾࢆ㉳ࡇࡍࡓࡵ㸪Ṛஸ⋡ࡀ㧗ࡃ࡞ࡾ⿕ᐖࡀ⏒࡞ࡿഴྥࡀ࠶ࡿ㸬 ᮏ◊✲࡛ࡣ㸪ᗣᡂேࢆᑐ㇟ࡋ࡚㸪⾜ືୖ᫂☜࡞࢚࣮ࣛࡔࡅ࡛࡞ࡃ㸪ࢽ࣑ࢫ ࡸ⾜ືୖ᫂☜࡛࡞࠸࢚࣮ࣛᑐࡍࡿὀព㓄ศཬࡰࡍ╀Ẽࡢᙳ㡪ࢆ᳨ウࡍࡿࡇ㸪 ╧╀㞀ᐖ≉╧╀↓྾ೃ⩌ࡢ㔜ᗘ㏻ᨾࣜࢫࢡࡢ㛵ಀࢆㄪࡿࡶ㸪 ㏻ᨾࢆ㜵Ṇࡍࡿࡓࡵࡢ⒪㛤ጞᇶ‽⒪ࢥࣥࣉࣛࣥࢫࡢ┠ᶆ್ࢆ☜❧ࡍࡿࡇ 㸪୍⯡ேཱྀ࠾ࡅࡿᒃ╀ࡾ㐠㌿ᨾࡢⓎ⌧せᅉ࠾ࡼࡧ᭷ຠ࡞╀Ẽᑐฎἲࢆ᫂ࡽ ࡍࡿࡇࢆ┠ⓗࡋ࡚㸪୍㐃ࡢ◊✲ࢆ⾜ࡗࡓ㸬 ᐇ㦂ᚰ⌮Ꮫⓗ◊✲ࡽࡣ㸪╀Ẽࡢᙉ࠸≧ἣ࡛ࡣసᴗ࢚࣮ࣛࡀቑຍࡍࡿࡔࡅ࡛࡞ࡃ㸪 ⮬ศࡢ࢚࣮ࣛẼ࡙ࡃ⬟ຊࡀపୗࡍࡿࡇࢆ♧ࡋࡓ㸬࢚࣮ࣛẼ࡙ࡃ⬟ຊࡀపୗࡍࢀࡤ㸪 ᙜ↛࢚࣮ࣛ㜵Ṇࡢࡓࡵࡢ⾜ືࢆࢀࡎ࢚࣮ࣛࢆᨺ⨨ࡋ࡚㸪ࡁ࡞ᨾࡘ࡞ࡀࡿྍ⬟ ᛶࡀ࠶ࡿ㸬╧╀ࡢ㔞ࡀ☜ಖࡉࢀ࡚࠸࡚ࡶ㸪╧╀ࡢ㉁ࡀᝏࡋ࡚࠸ࡿሙྜࡣ㸪᪥୰ ࡢ╀Ẽࡀ⏕ࡌ㸪㏻ᨾࡢࣜࢫࢡࡣቑࡍࡿ㸬⮫ᗋ㐃⥆◊✲ࡢ⤖ᯝࡽ㸪╧╀↓ ྾ೃ⩌ࡢᝈ⪅࡛ࡣ㏻ᨾࣜࢫࢡࡀ㧗࠸ࡇ㸪≉྾㞀ᐖࡀ㔜࡞ሙྜࡣ⮬ぬⓗ࡞ ╀Ẽホ౯ࡀ㕌ࡋ㸪ࡼࡾ㏻ᨾࣜࢫࢡࡀ㧗ࡲࡿࡇࡀ᫂ࡽ࡛࠶ࡗࡓ㸬╧╀↓྾ ೃ⩌ࢆ⒪ࡍࡿࡇ࡛㸪㏻ᨾࣜࢫࢡࡣᗣ࡞⪅ྠࡌỈ‽࡞ࡿࡇࡽ㸪᪩ ᮇⓎぢ࣭⒪ࡀᚲせ࡛࠶ࡿ㸬Ꮫㄪᰝࡢ⤖ᯝࡽ㸪╧╀㛫ࡀ 㛫ᮍ‶ࡢ⪅࡛ࡣ㸪 ᒃ╀ࡾ㐠㌿ࡢࣜࢫࢡࡀ᭷ពୖ᪼ࡋ࡚࠸ࡓ㸬㏻ᨾࢆ㜵Ṇࡍࡿࡓࡵࡣ㸪ኪࡢ╧╀ࢆ ࡁࡕࢇ☜ಖࡍࡿࡇࡀఱࡼࡾ㔜せ࡛࠶ࡿ㸬 ㏻ᨾࢆ㜵Ṇࡍࡿୖ࡛ࠕ╀Ẽࠖࡣ㔜せ࡞㘽ࢆᥱࡿ㸬ࢻࣛࣂ࣮ࡢ╧╀ࡢ㔞㉁ࡢᨵ ၿ㸪⏕ά⎔ቃ࣭ປാ᮲௳ࡢᩚഛ࣭ᕤኵ㸪㐠㌿ࡢ╀Ẽ᳨ฟ࠸ࡗࡓከ᪉㠃ࡽࡢࣉࣟ ࣮ࢳ࡛㸪╀Ẽࡼࡿ㏻ᨾ㜵Ṇྲྀࡾ⤌ࡴࡇࡀᚲせ࡛࠶ࡿ㸬 2 / 32 ┠ ḟ ࣄ࣮࣐࢚࣮࣭ࣗࣥࣛ㏻ᨾࢆㄏⓎࡍࡿ╀ẼࡢⓎ⏕せᅉᑐ⟇㛵ࡍࡿ⣔⤫ⓗ◊✲ ➨ ❶ࡣࡌࡵ ◊✲⫼ᬒ ◊✲┠ⓗ ➨ ❶ᐇ㦂ᚰ⌮Ꮫⓗ◊✲ ⫼ᬒ ᪉ἲ ⤖ᯝ ⪃ᐹ ➨ ❶⮫ᗋ㐃⥆◊✲ ⫼ᬒ ᪉ἲ ⤖ᯝ ⪃ᐹ ➨ ❶Ꮫ◊✲ ⫼ᬒ ᪉ἲ ⤖ᯝ ⪃ᐹ ➨ ❶ࡲࡵᚋࡢㄢ㢟 ཧ⪃ᩥ⊩ 㘓 3 / 32 ➨ ❶ ࡣࡌࡵ ◊✲⫼ᬒ ᒃ╀ࡾ㐠㌿ࡀཎᅉ࡛㸪୍ᗘከࡃࡢࡀዣࢃࢀࡿᨾࡀ ᖺ࠸ࡃࡘ㉳ࡇࡗࡓࡇࡣ グ᠈᪂ࡋ࠸㸬*: 㔠ἑࡽᮾிྥࡗ࡚㉮ࡗ࡚࠸ࡓ㧗㏿ࣂࢫࡀ㸪᫂ࡅ᪉㛵㉺⮬ື㌴㐨ࡢ 㜵㡢ቨ⾪✺ࡋ㸪ࢶ࣮ᐈ ྡ࠶ࡲࡾࡀṚയࡍࡿ࠸࠺ᨾࡀ࠶ࡗࡓ㸬⌧ሙࣈ࣮ࣞ࢟ࡸ ࢫࣜࢵࣉࡣぢࡘࡗ࡚࠾ࡽࡎ㸪㐠㌿ᡭࡣ⩌㤿┴㆙ ࠕᒃ╀ࡾࡋ࡚࠸ࡓࠖ ㄝ᫂ࡋࡓ㸦ᅗ 㸧㸬 ࡲࡓி㒔ᗓடᒸᕷ࡛㸪Ⓩᰯ୰ࡢඣ❺ᘬ⋡ࡢಖㆤ⪅ࡢิ㍍⮬ື㌴ࡀ✺ࡗ㎸ࡳ㸪ィ ேࡀࡣ ࡡࡽࢀ࡚ ேࡀṚஸ㸪 ேࡀ㔜㍍യࢆ㈇ࡗࡓᨾࡶ㸪↓චチ࡛㐠㌿ࡋ࡚࠸ࡓ ṓᑡᖺࡢᒃ╀ ࡾࡀཎᅉሗ㐨ࡉࢀ࡚࠸ࡿ㸬╀Ẽࡸᒃ╀ࡾࡀཎᅉ࡛㉳ࡇࡿᨾࡣ㸪ࣈ࣮ࣞ࢟ࡸࣁࣥࢻࣝ᧯స ࡼࡿ༴㝤ᅇ㑊⾜ືࡀࡽࢀࡎ㸪㧗㏿ࡢࡲࡲᨾࢆ㉳ࡇࡍࡓࡵ㸪Ṛஸ⋡ࡀ㧗ࡃ࡞ࡾ⿕ᐖࡀ⏒ ࡞ࡿഴྥࡀ࠶ࡿ㸬 ᅗ ᮅ᪥᪂⪺ ᖺ ᭶ ᪥ᮅห ╀Ẽᨾࡣᐦ᥋㛵㐃ࡋ࡚࠸ࡿ㸬ᅗ ࡣ⑂ປࡼࡿ⮬ື㌴ᨾࡢⓎ⏕௳ᩘࢆู้ ୪ࡓࡶࡢ࡛࠶ࡿ㸦0LWOHUHWDO㸧 㸬୍᪉㸪ᅗ ࡣ㸪ᐇ㦂ᐊෆ࡛ ᐃࡉࢀࡓᐈほⓗ ࡞╀Ẽࡢᣦᶆࢆࡶ㸪้ᖏูࡢ╀Ẽࢆᶍᘧࡋࡓࡶࡢ࡛࠶ࡿ㸦/DYLH㸧 㸬╀Ẽ ᨾ௳ᩘࡣ㸪ࡶ῝ኪࡽ᪩ᮅ㸪㐣ࡂࡢ㛫ᖏࣆ࣮ࢡࢆ᭷ࡋ࡚࠸ࡿࡢ࡛㸪୧⪅ࡀᐦ᥋ 㛵ࢃࡗ࡚࠸ࡿྍ⬟ᛶࡀ᥎ ࡉࢀࡿ㸬 4 / 32 ᅗ 1-2 ⑂ປ㛵㐃ࡋࡓ㏻ᨾࡢ ᅗ 1-3 ้ᖏูࡢ╀Ẽࡢᙉࡉ Ⓨ⏕้㸦Mitler et al., 1996㸧 㸦Lavie, 1985㸧 +RUQH5H\QHU ࡼࢀࡤ㸪╀Ẽ⏤᮶ࡋࡓᨾࡣ୍⯡㐨࡛ࡢ㏻ᨾࡢ 㸣㸪㧗㏿㐨㊰ ࡛ࡢࡑࢀࡢ 㸣ࢆ༨ࡵࡿ࠸࠺㸦+RUQHHWDO㸧㸬◊✲ࡼࡗ࡚ከᑡࡢᩘ್ࡢ㐪࠸ࡣ ࠶ࡿࡶࡢࡢ㸪ࡢㄪᰝ࠾࠸࡚ࡶ㸪ᑡ࡞ࡃࡶ㏻ᨾࡢ 㸣⛬ᗘࡣ╀Ẽ㛵㐃ࡋࡓᨾ࡛ ࠶ࡿሗ࿌ࡉࢀ࡚࠸ࡿ㸦0D\FRFNHWDO㸧㸬ࡲࡓᾏୖ㏻࠾࠸࡚ࡶ 㸣ࡢᨾࡀ ᒃ╀ࡾࡼࡿ⪃࠼ࡽࢀ࡚࠾ࡾ㸪⾪✺࣭ࡾୖࡆᨾ㝈ࢀࡤ 㸣ࡢᨾࡢཎᅉࡀᒃ╀ࡾ ᥎ᐃࡉࢀ࡚࠸ࡿ㸦ᇼ㸧 㸬ࡉࡽ⯟✵ᶵᨾࡢཎᅉࡋ࡚㸪ᶵ㛗ࡢ╧╀㊊ࡀ㛵ࡋ࡚ ࠸ࡿ⪃࠼ࡽࢀࡿᨾࡶᩓぢࡉࢀࡿ㸬ࡋࡓࡀࡗ࡚㸪㝣㸪ᾏ㸪✵ࡢ㏻Ᏻࢆ⪃࠼ࡿୖ࡛㸪ᒃ ╀ࡾ㐠㌿ᑐ⟇ࡀࡁࢃࡵ࡚㔜せ࡛࠶ࡿࡇࡣ㛫㐪࠸࡞࠸㸦ᅗ 㸧 㸬/HJHU ࡣ㸪 ᖺࡢ㸯ᖺ㛫 ࠾࠸࡚⡿࡛ 㹼 ൨ࢻࣝࡢᦆᐖࡀ╧╀⏤᮶ࡍࡿ㏻ᨾࡼࡗ࡚ࡶࡓࡽࡉࢀ࡚࠸ ࡿヨ⟬ࡋ࡚࠸ࡿ㸦/HJHU㸧㸬ࢃࡀᅜ࠾࠸࡚ࡶ㸪ᒃ╀ࡾᨾࡼࡿ⤒῭ᦆኻࡣ㸪Ⳙ ࡞㔠㢠ࡢࡰࡿࡇࡀணࡉࢀࡿ㸬 ◊✲┠ⓗ ╀Ẽࡣ㸪ࣄ࣮࣐࢚࣮࣭ࣗࣥࣛ㏻ᨾࢆᘬࡁ㉳ࡇࡍせ࡞ཎᅉࡢ୍ࡘ࡛࠶ࡿ㸬᪥୰㐣 ࡞╀Ẽ㸦([FHVVLYHGD\WLPHVOHHSLQHVV('6㸧ࢆッ࠼ࡿேࡢྜࡣ㸪Ḣᕞ ࢝ᅜ ྡ ࢆᑐ㇟ࡋࡓㄪᰝ㸦2KD\RQHWDO㸧࡞ࡽࡧ᪥ᮏࡢᡂே ྡࢆᑐ㇟ࡋࡓㄪᰝ㸦/LX HWDO㸧࠾࠸࡚㸪࠸ࡎࢀࡶ 㸣㐩ࡋ࡚࠸ࡿ㸬('6 ࡢཎᅉࡋ࡚ࡣ㸪╧╀㔞ࡢ⤯ ᑐⓗ࡞㊊㸪ᴫ᪥ࣜࢬ࣒ᶵᵓࡢኚㄪ㸪㛢ሰᛶ╧╀↓྾ೃ⩌㸦26$6㸧࡞ࡼࡿ ኪ㛫╧╀ศ᩿࡞ࡀᣲࡆࡽࢀࡿ㸬 5 / 32 ᅗ ╀Ẽࡀཎᅉࡢࡦࡘ⪃࠼ࡽࢀ࡚࠸ࡿᨾࡢ ᕥୖᅗ㸸ࢫ࣮࣐ࣜࣝᓥཎᏊຊⓎ㟁ᡤᨾ㸦㸧 㸪ᕥୗᅗ㸸ࢫ࣮࣌ࢫࢩࣕࢺࣝࢳࣕࣞࣥࢪࣕ ࣮ྕᨾ㸦㸧 㸪ྑᅗ㸸࢚ࢡࢯࣥ♫ࣂࣜࢹ࣮ࢬྕᗙ♋࣭ཎἜὶฟᨾ㸦㸧 ╀Ẽᨾ㛵ࡍࡿࡇࢀࡲ࡛ࡢ◊✲ࡣ㸪᩿╀㈇Ⲵࡋ╀ẼỈ‽ࢆୖ᪼ࡉࡏࡓ≧ἣୗ࡛ࡢ㐠㌿ ࢩ࣑࣮ࣗࣞࢱ࣮ᐇ㦂㛵ࡍࡿࡶࡢࡀከࡃ㸪Ꮫⓗᡭἲࡼࡾᒃ╀ࡾᨾࡢⓎ⌧≧ἣࡸᨾࡢ ཎᅉ࡞ࡗࡓ╀ẼࡢⓎ⌧せᅉࢆヲ⣽ゎᯒࡋࡓ◊✲ࡣᩘᑡ࡞࠸㸬ࡲࡓ㸪ᡃࡀᅜ࠾࠸࡚ࡣ㸪 ╧╀㞀ᐖ㏻ᨾࡢ㛵ಀࢆ⣔⤫ⓗ᳨ウࡋࡓ◊✲ࡣぢᙜࡓࡽ࡞࠸㸬ࡉࡽ㸪ᨾࡢ㜵Ṇ ࠸࠺ほⅬࡽ⪃࠼ࡿ㸪࢚࣮ࣛᩘࡢపῶྠᵝ㸪 ࠕ࢚࣮ࣛࢆࡋࡓࡇࢆࡍࡄẼࡃ࠺ 㸦᳨࢚࣮ࣛฟ㸧ࠖ㸪 ࠕ⾜ືୖ᫂☜࡛࡞࠸࢚࣮ࣛ㸦ࢽ࣑ࢫࡸᚤ⣽࡞࢚࣮ࣛ㸧ࡢ᳨ฟ࣭ὀពࡀྍ⬟ ࠺ࠖ㛵ࡍࡿ࢚ࣅࢹࣥࢫࡢ✚ࡀᚲせ࡛࠶ࡿ㸬 ࡑࡇ࡛㸪ᮾி་⛉Ꮫ╧╀Ꮫㅮᗙබ┈㈈ᅋἲே⚄⤒◊✲ᡤ╧╀Ꮫࢭࣥࢱ࣮ࡢ◊✲ࣉࣟࢪ ࢙ࢡࢺ࡛ࡣ㸪㐠㌿୰ࡢ╀ẼⓎ⌧㛵㐃ࡍࡿせᅉண㜵⟇ࢆ᫂ࡽࡍࡿࡓࡵ㸪Ꮫㄪᰝ࣭26$6 ᝈ⪅ࡢ⮫ᗋ㐃⥆◊✲࣭ᐇ㦂ᚰ⌮Ꮫⓗ◊✲ࢆ⣔⤫ⓗᐇࡋࡓ㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪ᗣ ᡂேࢆᑐ㇟ࡋ࡚㸪⾜ືୖ᫂☜࡞࢚࣮ࣛࡔࡅ࡛࡞ࡃ㸪ࢽ࣑ࢫࡸ⾜ືୖ᫂☜࡛࡞࠸࢚࣮ࣛ ᑐࡍࡿὀព㓄ศཬࡰࡍ╀Ẽࡢᙳ㡪ࢆ᳨ウࡍࡿࡇ㸪╧╀㞀ᐖ≉╧╀↓྾ೃ⩌ ࡢ㔜ᗘ㏻ᨾࣜࢫࢡࡢ㛵ಀࢆㄪࡿࡶ㸪㏻ᨾࢆ㜵Ṇࡍࡿࡓࡵࡢ⒪㛤ጞᇶ ‽⒪ࢥࣥࣉࣛࣥࢫࡢ┠ᶆ್ࢆ☜❧ࡍࡿࡇ㸪୍⯡ேཱྀ࠾ࡅࡿᒃ╀ࡾ㐠㌿ᨾ ࡢⓎ⌧せᅉ࠾ࡼࡧ᭷ຠ࡞╀Ẽᑐฎἲࢆ᫂ࡽࡍࡿࡇ࡛࠶ࡿ㸬 6 / 32 ➨ ❶ ᐇ㦂ᚰ⌮Ꮫⓗ◊✲ ⫼ᬒ ࣎ࢱࣥࡢᢲࡋ㛫㐪࠸ࡢࡼ࠺࡞㸪ㄗᛂᥞ࠼࡚⬻Ἴࢆຍ⟬ᖹᆒࡍࡿ㸪㢧ⴭ࡞ ࡘࡢ㇟ 㛵㐃㟁ࡢᡂศࡀㄆࡵࡽࢀࡿ㸬୰ᚰ㒊ࡼࡾࡸࡸ๓ࡼࡾࡢ㒊ฟ⌧ࡍࡿ㝜ᛶᡂศࡣ㸪 (UURU5HODWHG1HJDWLYLW\(51ࡤࢀ㸪㐣ཤࡢ◊✲⤖ᯝࡽ㸪᳨࢚࣮ࣛฟࢆᫎࡋ࡚࠸ ࡿ⪃࠼ࡽࢀ࡚࠸ࡿ㸬ࡲࡓ㸪୰ᚰ㒊ࡼࡾࡸࡸᚋࢁࡼࡾࡢ㒊ฟ⌧ࡍࡿ㝧ᛶᡂศࡣ HUURU 3RVLWLYLW\3Hࡼࡤࢀ㸪⮬ࡽࡢ࢚࣮ࣛᑐࡍࡿヲ⣽࡞ほⓗホ౯㐣⛬ࢆᫎࡋ࡚࠸ࡿ⪃ ࠼ࡽࢀ࡚࠸ࡿ㸬3H ࡣ⮬ࡽࡢ࢚࣮ࣛᛂᑐࡍࡿ 3 ࡛࠶ࡿ⪃࠼ࡽࢀ࡚࠾ࡾ㸪ኻᩋᑐࡋ࡚ ከࡃࡢὀពࢆᡶ࠺ࡼ࠺࡞≧ἣ࡛ࡢᖜቑࡀ☜ㄆࡉࢀ࡚࠸ࡿ㸦ᅗ 㸧㸬ࡇࡽࡽࡢ㟁ࡣ㸪ࣃ ࣇ࢛࣮࣐ࣥࢫࣔࢽࢱࣜࣥࢢ㸦࢚࣮ࣛฎ⌮㐣⛬㸧ࡢ᭷ຠ࡞ᣦᶆࡋ࡚ከࡃࡢ◊✲࡛⏝࠸ࡽࢀ࡚ ࠸ࡿ㸬 Error-Related Negativity/error Negativity (ERN/Ne) •䜶䝷䞊᳨ฟ (⮬䜙䛾䜶䝷䞊䜈䛾Ẽ䛵䛝) 䜢ᫎ ㄗᛂ (Falkenstein et al., 1994; Gehring et al., 1993) : 䝪䝍䞁䛾ᢲ䛧㛫㐪䛔 error Positivity (Pe) •⮬䜙䛾䜶䝷䞊䛻ᑐ䛩䜛ヲ⣽䛺ほⓗホ౯㐣 ⛬ (ព㆑ⓗㄆ㆑) 䜢ᫎ (Falkenstein et al., 2004) •⮬䜙䛾䜶䝷䞊ᛂ䛻ᑐ䛩䜛P3 (Davies et al., 2001; Overbeek et al., 2005) ᅗ ࢚࣮ࣛ㛵㐃ࡋࡓ㇟㛵㐃㟁 ࡇࢀࡲ࡛ࡢ◊✲࡛㸪╀Ẽࡢᙉ࠸≧ἣ࡛ࡣసᴗ࢚࣮ࣛࡀቑຍࡍࡿࡔࡅ࡛࡞ࡃ㸪⮬ศࡢ࢚࣮ࣛ Ẽ࡙ࡃ⬟ຊࡀపୗࡋ㸪࢚࣮ࣛᑐࡍࡿὀព㓄ศࡶᦆ࡞ࢃࢀࡿࡇࡀ♧၀ࡉࢀ࡚࠸ࡿHJ 6FKHIIHUVHWDO7VDLHWDO㸬㏻ᨾ㜵Ṇ࠸࠺ほⅬࡽ⪃࠼ࡿ㸪࢚ ࣮ࣛᩘࡢపῶࡣࡶࡕࢁࢇࡢࡇ㸪⮬ศࡢసᴗᡂ⦼ࢆࡁࡕࢇホ౯࡛ࡁࡿ㸪࢚࣮ࣛࡋࡓࡇ ࡍࡄẼ࡙ࡃ࠺㸪࢚࣮ࣛᑐࡍࡿὀព㓄ศࡀࡁࡕࢇ⾜ࢃࢀ࡚࠸ࡿ࠺㸪࢚࣮ࣛ 㜵Ṇࡢࡓࡵ⾜ືኚᐜࡀ࡛ࡁࡿ࠺ࡀ㔜せ࡛࠶ࡿ㸬 ࡇࡢ࢚࣮ࣛ㛵㐃ࡋࡓ㇟㛵㐃㟁 (51 3H ࢆᣦᶆ⏝࠸࡚࢚࣮ࣛࣔࢽࢱࣜࣥࢢᶵ⬟ ࠼ࡿ╀Ẽࡢᙳ㡪ࢆ᳨ウࡋࡓ◊✲ࡣ㸪ࡇࢀࡲ࡛ࡶ」ᩘᏑᅾࡍࡿࡀ㸪ࡑࡢከࡃࡣ 㛫௨ୖࡢ 7 / 32 ᩿╀ࡼࡗ࡚⏕ࡌࡓ╀Ẽࡢᙳ㡪ࢆ᳨ウࡋࡓࡶࡢ࡛࠶ࡗࡓHJ6FKHIIHUVHWDO 7VDLHWDO0XUSK\HWDO㸬ࡋࡋ㸪╀Ẽࡀ⏕ࡌࡿࡢࡣ᩿╀ࡢࡳ࡛ࡣ࡞࠸㸬 ࡑࡇ࡛㸪ᡃࠎࡣ௬╀ᚋࡢ╧╀័ᛶぬ㓰ᚋ╀Ẽࡀṧࡿ≧ែ╔┠ࡋ㸪ࡑࢀࡼࡗ࡚ᘬࡁ ㉳ࡇࡉࢀࡓ╀Ẽࡀ࢚࣮ࣛࣔࢽࢱࣜࣥࢢ࠼ࡿᙳ㡪ࡘ࠸᳨࡚ウࡋ࡚ࡁࡓ$VDRNDHWDO 㸬ᅗ ࡣ㸪᪥୰ྲྀᚓࡋࡓ 㛫ࡢ௬╀┤ᚋᐇࡋࡓㄢ㢟୰ࡢ (51࣭3H ࢆ㸪ྠ้ ࡢఇ᠁ᚋࡢㄢ㢟୰ࡢ (51࣭3H ẚ㍑ࡋࡓࡶࡢ࡛࠶ࡿ㸬ᅗࡢᕥഃࡢ 6HVVLRQ௬╀࣭ఇ᠁ࡢ ๓࡛ࡣ㸪ఇ᠁᮲௳◚⥺௬╀᮲௳ᐇ⥺ࡢἼᙧࡢ㛫ࡁ࡞㐪࠸ࡣㄆࡵࡽࢀ࡞ࡗ ࡓ㸬ࡋࡋ 6HVVLRQ௬╀࣭ఇ᠁┤ᚋ࠾ࡅࡿ 3] ࡢ㒊ࡢἼᙧᅗྑୗ࡛ࡣ㸪ఇ᠁ᚋࡢ ᮲௳ẚ㍑ࡋ࡚㸪௬╀┤ᚋ࡛᭷ព 3H ࡢᖜࡀῶ⾶ࡋ࡚࠸ࡓ㸬ࡇࡢࡇࡣ㸪௬╀┤ᚋࡢ╧╀ ័ᛶࡣ࢚࣮ࣛࡢほⓗホ౯ࡸὀព㓄ศ㔞ࡀపୗࡋ㸪⮬ࡽࡢࣃࣇ࢛࣮࣐ࣥࢫࡢ㐣ホ౯ ࡋࡀࡕ࡞ࡿ༴㝤ᛶࢆᣦࡍࡿࡶࡢ࠸࠼ࡿ㸬୍᪉࡛㸪ṇゎ⋡ࡸᛂ㛫ࡣ᭷ព࡞ᕪࡣ᮲ ௳㛫ㄆࡵࡽࢀ࡞ࡗࡓ⾲ 㸬ࡇࡢ⤖ᯝࡣ㸪ṇゎ⋡ࡸᛂ㛫ࡢࡼ࠺࡞⾜ືᣦᶆࡼࡾࡶ㸪 ࢚࣮ࣛࡢὀព㓄ศࡸほⓗホ౯ࡢ㐣⛬ࡀ╀Ẽ⬤ᙅ࡛࠶ࡿྍ⬟ᛶࢆᣦࡍࡿࡶࡢ⪃࠼ࡽ ࢀࡓ㸬 ᅗ ௬╀࣭ఇ᠁๓ᕥ6HVVLRQ┤ᚋྑ6HVVLRQ࠾ ࡅࡿ (51࣭3Hᖜࡢẚ㍑$VDRNDHWDO ⾲ ఇ᠁᮲௳ᕥ௬╀᮲௳ྑ࠾ࡅࡿㄢ㢟ᡂ⦼$VDRNDHWDO 8 / 32 ᅗ ࡣ㸪ୖグྠࡌ 㛫ࡢ௬╀ࢆ῝ኪ ࡽࡏࡓ㝿ࡢ (51࣭3H ࡛࠶ࡿ$VDRNDHW DO㸬ぬ㓰ࡢࣞ࣋ࣝࡢ㧗࠸ ࡢⅬẚ㍑ࡋ࡚㸪῝ኪ 㸪 ࠾ࡅࡿ 3H ࡣ᭷ ពపୗࡋ࡚࠾ࡾ㸪ぬ㓰㛫ࡢᘏ㛗ࡼࡿ╀Ẽࡀ࢚࣮ࣛࡢほⓗホ౯㐣⛬ࡸ࢚࣮ࣛᑐࡍࡿ ὀព㓄ศࢆ㞀ᐖࡋ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡿ㸬ࡋࡋ㸪௬╀ࢆࡗࡓሙྜኴ⥺࡛ࡶ㸪ఇ᠁ ࡢࡳ⣽⥺ẚ㍑ࡋ࡚ࡑࡢῶ⾶ࡢ᪉ኚࡣㄆࡵࡽࢀࡎ㸪῝ኪᖏࡢ 㛫ࡢ௬╀ࡸࡑࡢ ᚋࡢ╧╀័ᛶࡣ࢚࣮ࣛࣔࢽࢱࣜࣥࢢ㢧ⴭ࡞ᙳ㡪ࢆ࠼࡞࠸ࡇࡀ♧ࡉࢀࡓ㸬୍᪉࡛㸪⾜ື ᣦᶆࡣ௬╀ࡢ᭷↓ࡼࡗ࡚ᕪࡀㄆࡵࡽࢀ㸪௬╀ࢆࡿࡇࡼࡗ࡚㸪῝ኪࡽ᫂ࡅ᪉ࡲ࡛ ࡢ㛫ᖏ࠾ࡅࡿᛂࡢṇ☜ᛶࡀ⥔ᣢࡉࢀࡿࡇࡀ♧ࡉࢀࡓᅗ 㸬ࡋࡓࡀࡗ࡚㸪ࡇࡢ◊ ✲⤖ᯝࡶ㸪࢚࣮ࣛᛂࡢࣔࢽࢱࣜࣥࢢ㐣⛬ࡀ╀Ẽ⬤ᙅ࡛࠶ࡿ⡆༢ࡣᅇࡋ࡞࠸ࡇ ࢆ♧၀ࡍࡿࡶࡢ࠸࠼ࡿ㸬 ᅗ ῝ኪࡢ 㛫ࡢ௬╀ࡀ (51࣭3H ᖜ࠼ࡿຠᯝ$VDRNDHWDO ᅗ ῝ኪࡢ 㛫ࡢ௬╀ࡀㄆ▱ㄢ㢟࠾ࡅࡿ ṇゎ⋡࠼ࡿᙳ㡪$VDRNDHWDO 9 / 32 ࡇࢀࡲ࡛ࡢ◊✲⤖ᯝࢆ㋃ࡲ࠼㸪ᡃࠎࡣୗグࡢ 2 Ⅼࡘ࠸᳨࡚ウࢆ⾜ࡗࡓ㸬ࡲࡎ㸪ᐇ㦂Ϩ ࡋ࡚㸪╧╀ࡢ㉁ࡢపୗࡀ࢚࣮ࣛᛂࡢࣔࢽࢱࣜࣥࢢ࠼ࡿᙳ㡪ࢆ᳨ウࡋࡓ㸬ࡇࢀࡲ࡛ࡶ ╧╀୰㡢ࢆᥦ♧ࡍࡿ࡞ࡋ࡚╧╀ࡢ㉁ࢆᝏࡉࡏࡓሙྜࡣ㸪⩣᪥ࡢㄆ▱ⓗࣃࣇ࢛࣮࣐ࣥ ࢫࡀᝏࡍࡿࡇࡣ᫂ࡽࡉࢀ࡚࠸ࡿࡀ (e.g., Elmenhorst et al., 2010)㸪࢚࣮ࣛᛂࡢࣔࢽ ࢱࣜࣥࢢ࠼ࡿᙳ㡪ࡣ᫂ࡽ࡞ࡗ࡚࠸࡞࠸㸬⥆࠸࡚ᐇࡋࡓᐇ㦂ϩ࡛ࡣ㸪࢚࣮ࣛࡢࡁ ࡉࡢ㐪࠸ࡼࡗ࡚㸪╀Ẽࡀ࢚࣮ࣛࣔࢽࢱࣜࣥࢢ࠼ࡿᙳ㡪ࡀ␗࡞ࡿ࠺ࢆ᳨ウࡋࡓ㸬 ࡇࢀࡲ࡛ࡢ◊✲࡛ࡣ㸪࣎ࢱࣥࡢᢲࡋ㛫㐪࠸ࡢࡼ࠺࡞ࣁࢵ࢟ࣜࡋࡓ࢚࣮ࣛᑐࡍࡿࣔࢽࢱࣜ ࣥࢢ㐣⛬ࡘ࠸᳨࡚ウࡀ࡞ࡉࢀ࡚ࡁࡓࡀ㸪᪥ᖖ⏕ά࡛ࡣ࢚࣮ࣛࡢࡁࡉࡀ୍ᵝ࡛ࡣ࡞࠸ࡇ ࡶከ࠸㸬ṇゎࡽࡅ㞳ࢀࡓ᫂☜࡞࢚࣮ࣛࡀᏑᅾࡍࡿ୍᪉࡛㸪ṇゎ㠀ᖖ㏆࠸࢚࣮ࣛࡶᏑ ᅾࡋ㸪࢚࣮ࣛࣔࢽࢱࣜࣥࢢ࠼ࡿ╀Ẽࡢᙳ㡪ࡀ࢚࣮ࣛࡢࡁࡉࡼࡗ࡚␗࡞ࡿྍ⬟ᛶࡶྰ ᐃ࡛ࡁ࡞࠸㸬 ᪉ἲ ᐇ㦂Ϩ ╧╀㞀ᐖࡢ↓࠸ ྡࡢ⏨ᛶs ṓ ṓࢆᑐ㇟ࡋ࡚ᐇ㦂 ࢆ⾜ࡗࡓ㸬ᐇ㦂๓ኪࡢ╧╀ࢆ ⤫ไࡋ㸪ᐇ㦂ᙜ᪥ࡢᐷ࢝ࣇ࢙ࣥᦤྲྀࢆ⚗Ṇ ࡋࡓ㸬ᐇ㦂᪥௨๓㸪㡰ᛂኪࢆタࡅᐇ㦂ᐊෆ࡛ 㸸㸸 ࡢ╧╀ࢆࡽࡏ㸪36* ࢆグ㘓ࡋ ࡓ㸬ࡲࡓ྾ࡸ⬮㒊ࡢ➽㟁ᅗࡶグ㘓ࡋ㸪╧╀㞀ᐖࡢ࡞࠸ࡇࢆ☜ㄆࡋࡓ㸬 ୖ㏙ࡢ㡰ᛂኪࡢᚋ㸪ᐇ㦂ཧຍ⪅ࡣᐇ㦂ᐊ࡛ 㸸 ࡢ╧╀ࢆኪࡗࡓ㸬࠸ࡎࢀࡢ᮲ ௳࡛ࡶ╧╀୰ࡢ⬻Ἴ㸪║㟁㸪➽㟁ࢆグ㘓ࡋ3RO\VRPQRJUDSK36*㸪ᐇ㦂ᚋ╧╀ẁ㝵 ࢆุᐃࡋࡓ㸬୍ᬌࡣ㏻ᖖ㏻ࡾ╧╀ࢆࡾQRUPDO ᮲௳㸪ࡶ࠺୍ᬌࡣᚎἼ╧╀ࡀㄆࡵࡽࢀ ࡓⅬ࡛ 3& ࡽ㡢ࢆ㬆ࡽࡋ࡚╧╀ࢆ㜼ᐖࡋࡓGLVWXUE ᮲௳㸬 ࠸ࡎࢀࡢ᮲௳࡛ࡶ㸪㉳ᗋᚋㄆ▱ㄢ㢟ࢆᐇࡋࡓ㸬ㄢ㢟ࡣ )ODQNHU ㄢ㢟ࢆ⏝࠸ࡓ㸬ࡇࡢ ㄢ㢟࡛ࡣ㸪ὀどⅬPV ࡛ࣛࣥࢲ࣒ኚࢆᥦ♧ࡋࡓᚋ㸪+++++㸪++6++㸪66666㸪66+66 ࡢ ✀㢮ࡢ่⃭ࡢ࠺ࡕࡢ୍ࡘࢆᥦ♧ࡋࡓ㸬ᥦ♧ࡉࢀࡓ ᩥᏐࡢ୰ኸࡀ 6 ࡢሙྜࡣྑᡭ࡛ + ࡢ ሙྜࡣᕥᡭ࡛ᑐᛂࡍࡿ࣎ࢱࣥࢆᢲࡍࡼ࠺ᩍ♧ࡋࡓ㸬 ᐇ㦂ϩ ╧╀㞀ᐖࢆ᭷ࡋ࡞࠸ᗣⱝᖺᡂே ྡࢆᑐ㇟ࡋ࡚㸪㏻ᖖ╧╀ᚋࡢ᪥୰ ᪥୰᮲௳㸪᩿╀୰῝ኪ᮲௳ࡑࢀࡒࢀㄆ▱ㄢ㢟ࢆᐇࡋ㸪ㄢ㢟୰ࡢ⬻Ἴࢆグ㘓ࡋࡓ㸬 ࠸ࡎࢀࡢ᮲௳᪥୰࣭῝ኪ࠾࠸࡚ࡶ㸪௨ୗࡢࢱ࣑ࣥࢢㄢ㢟ࢆᐇࡋࡓ㸬ࡇࡢㄢ㢟࡛ࡣ㸪 ࡲࡎࣃࢯࢥࣥࡢࢹࢫࣉࣞୖ㸪ᮏࡢ㯮⥺ỈⰍࡢ㛗᪉ᙧ୍ࡘࡀᥦ♧ࡉࢀࡓ㸬ỈⰍࡢ㛗 ᪉ᙧࡣᕥࡢ㯮⥺ୖࡽ㸪ྑࡢ㯮⥺᪉ྥỈᖹ⛣ືࡋࡓᅗ 㸬ཧຍ⪅ࡣ㸪ᡭඖࡢ࣐ ࢘ࢫࢆ୍ᗘࢡࣜࢵࢡࡋ࡚⛣ືࡍࡿ㛗᪉ᙧࢆྑࡢ㯮⥺ୖṆࡉࡏࡿࡼ࠺ᣦ♧ࡋࡓ㸬 ᮏᐇ㦂 䜛ㄢ㢟 ᶍᘧ 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᅗ 㻞㻙㻡㻌 ᮏᐇ㦂䛷⏝䛔䜛ㄢ㢟䛾ᶍᘧᅗ 10 / 32 ⤖ᯝ ᐇ㦂Ϩ ᅗ 㸪࢚࣮ࣛᛂྜࢃࡏ࡚ຍ⟬ࡋࡓ㇟㛵㐃㟁ࢆ♧ࡋࡓ㸬(51 ࡢᖜࡣ㸪᮲௳㛫᭷ព࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓ㸬3H 㛵ࡋ࡚ࡣ &] ࠾ࡅࡿᖜࡀ 'LVWXUE ᮲௳࡛ 1RUPDO ᮲௳ࡼࡾࡶపୗࡋ࡚࠸ࡓ㸬ࡋࡋ㸪3] ࠾࠸࡚ࡣᖜ᭷ព࡞ᕪࡣㄆࡵࡽࢀ ࡞ࡗࡓ㸬⾜ືᣦᶆ㛵ࡋ࡚ࡣ㸪'LVWXUE ᮲௳࠾࠸࡚㸪ᛂ㛫ࡀ㐜ᘏࡋ㸪ṇᛂ⋡ࡶప ୗࡍࡿഴྥࡀㄆࡵࡽࢀࡓࡀ㸪ࡑࡢᕪࡣ᭷ព࡛ࡣ࡞ࡗࡓ㸬 ERN/Ne -15 ȝ9 9 -10 Normal FCz Disturb Cz Pz -5 0 5 10 Pe 15 -600 -400 -200 0 200 400 600 -600 -400 -200 0 200 400 600 -600 -400 -200 0 200 400 600 ms ᅗ 1RUPDO ᮲௳ 'LVWXUE ᮲௳࡛ࡢ (53 ࡢẚ㍑ ᐇ㦂ϩ Ṇ⨨ᣦᐃ⠊ᅖࡢࢬࣞࡢࡁࡉࡼࡗ࡚࢚࣮ࣛᛂࢆ࣭ᑠศ㢮ࡋ ࡓ㸬᳨ᐃࡢ⤖ᯝ㸪࢚࣮ࣛ↓ᛂࡢᅇᩘࡣኪ㛫᮲௳࡛ቑຍࡋ࡚࠸ࡓࡀ㸪ᑠ࢚࣮ࣛࡢᅇᩘ ࡣ᭷ពᕪࡀㄆࡵࡽࢀ࡞ࡗࡓ㸬ᛂࢆࢺ࣮ࣜ࢞ࡋࡓ㇟㛵㐃㟁࡛ࡣ㸪ᑠ࢚࣮ࣛࡢ 3 ᖜࡢࡳ᮲௳㛫࡛ᕪࡀㄆࡵࡽࢀ㸪ኪ㛫᮲௳࡛ࡑࡢᖜࡀపୗࡋ࡚࠸ࡓ㸬 ⪃ᐹ ᐇ㦂Ϩ࠾࠸࡚ㄆࡵࡽࢀࡓ 'LVWXUE ᮲௳࡛ࡢ &] ࠾ࡅࡿ 3H ᖜࡢపୗࡣ㸪╧╀ࡢ㉁ࡢప ୗࡼࡗ࡚ࡶ㸪࢚࣮ࣛࡢほⓗホ౯㐣⛬ࡀ㞀ᐖࡉࢀ࠺ࡿࡇࢆ♧ࡋ࡚࠸ࡿ㸬ࡋࡓࡀࡗ࡚㸪 ╧╀㛫ࡢࡳ࡛࡞ࡃ㸪╧╀ࡢ㉁ࡶ☜ಖࡍࡿࡇࡀᨾ㜵Ṇࡗ࡚ࡶ㔜せ࡛࠶ࡿ࠸࠼ࡿ㸬 ࡋࡋ㸪3] ࠾࠸࡚ࡣ 3H ᖜᕪࡀㄆࡵࡽࢀ࡞ࡗࡓ㸬ࡇࡢ ᐃ㒊ࡼࡿ⤖ᯝࡢ㐪࠸ ࡘ࠸࡚ࡣ㸪๓㢌ⴥࡀ╀Ẽ⬤ᙅ࡛࠶ࡿࡇ㛵㐃ࡋ࡚࠸ࡿ⪃࠼ࡽࢀࡿࡀ㸪ᚋࡢヲ⣽࡞᳨ ウࡀᚲせ࡛࠶ࢁ࠺㸬 ࡲࡓ࢚࣮ࣛࡢ᳨ฟࢆᫎࡍࡿ (51 㛵ࡋ࡚ࡣ㸪ࡑࡢᖜࡣ㐪࠸ࡀㄆࡵࡽࢀ࡞ࡗࡓ㸬ࡇ ࢀࡣ㸪 㛫ࡢ᩿╀ࢆ⏝࠸ࡓ 0XUSK\ ࡽࡢ◊✲0XUSK\HWDO⤖ᯝࡸ㸪ᡃࠎࡢ⾜ࡗ ࡓ᪥୰ࡢ௬╀┤ᚋࡢ╧╀័ᛶࡢ⤖ᯝ$VDRNDHWDO㢮ఝࡋ࡚࠸ࡿ㸬ࡇࢀࡽࡢඛ ⾜◊✲ࡢ୰࡛ࡶ㏙ࡽࢀ࡚࠸ࡿࡼ࠺㸪(51 ᖜᫎࡉࢀࡿ᳨࢚࣮ࣛฟᶵ⬟ẚ㍑ࡋ࡚ 3H ᖜᫎࡉࢀࡿ࢚࣮ࣛࡢほⓗホ౯㐣⛬ࡢ࠺ࡀ╀Ẽ⬤ᙅ࡛࠶ࡿࡇࡀ㸪ᐇ㦂Ϩ࡛ࡶ☜ ㄆ࡛ࡁࡓ㸬 ◊✲ϩ࡛ࡣ㸪῝ኪ࠾࠸࡚ᑠࡉ࡞࢚࣮ࣛᑐࡍࡿ 33Hᖜࡣపୗࡋ࡚࠸ࡓࡀ㸪᫂☜࡞ ࢚࣮ࣛᑐࡍࡿ 33Hࡣపୗࡀㄆࡵࡽࢀ࡞ࡗࡓ㸬ᚋ㸪ࡼࡾヲ⣽࡞᳨ウࢆࡋ࡚࠸ࡃᚲ せࡣ࠶ࡿࡀ㸪ࡇࡢ⤖ᯝࡣ࢚࣮ࣛࡢࡁࡉࡼࡗ࡚࢚࣮ࣛࣔࢽࢱࣜࣥࢢᶵ⬟࠼ࡿ╀Ẽࡢᙳ 㡪ࡀ␗࡞ࡿࡇ♧၀ࡋ࡚࠸ࡿࡢࡶࡋࢀ࡞࠸㸬 11 / 32 ࡇࢀࡲ࡛ࡢᐇ㦂ࡽࡣ㸪⮬ศࡢ⾜ືࢆᢕᥱ࣭ホ౯ࡍࡿ⬟ຊࡶ╀Ẽࡼࡗ࡚㞀ᐖࡉࢀࡿࡇ㸪 ࡇࢀࡣ༢⣧࡞⾜ືᣦᶆ㸦ࣃࣇ࢛࣮࣐ࣥࢫ㸧ࡼࡾࡶ╀Ẽ⬤ᙅ࡛࠶ࡿࡇ㸪ࡋࡓࡀࡗ࡚㸪⾜ື ᣦᶆࡀ᫂ࡽపୗࡍࡿࡢ╀Ẽࡀ⏕ࡌ࡚࠸ࡿ㝿ࡣ㸪ࡑࡢపୗࢆṇࡋࡃㄆ㆑࡛ࡁ࡞࠸≧ ែ࡛࠶ࡿࡇࢆ᫂ࡽࡋ࡚ࡁࡓ㸬ᅇ㸪ᐇࡋࡓ ࡘࡢᐇ㦂ࡢ⤖ᯝࡣ㸪╧╀ࡢ㉁ࡢపୗ ࡼࡗ࡚ࡶ࢚࣮ࣛࣔࢽࢱࣜࣥࢢᶵ⬟ࡀ㞀ᐖࡉࢀ࠺ࡿࡇ㸪᫂☜࡞࢚࣮ࣛᑐࡍࡿࣔࢽࢱࣜࣥࢢ ẚ㍑ࡋ࡚㸪ᑠࡉ࡞࢚࣮ࣛᑐࡍࡿࣔࢽࢱࣜࣥࢢࡢ࠺ࡀ╀Ẽ⬤ᙅ࡛࠶ࡿྍ⬟ᛶࡀ࠶ࡿࡇ ࢆ♧၀ࡋ࡚࠸ࡿ㸬ᡃࠎࡣ㸪᩿╀ࡸ╧╀័ᛶ㸪╧╀ࡢ㉁ࡢపୗ࡞㸪╀Ẽࢆ⏕ࡌࡉࡏࡿ」ᩘ ࡢᡭ⥆ࡁࢆ⏝࠸᳨࡚ウࢆ⾜ࡗ࡚ࡁࡓࡀ㸪࠸ࡎࢀࡢᡭ⥆ࡁࢆ⏝࠸ࡓ㝿ࡶ࢚࣮ࣛࣔࢽࢱࣜࣥࢢ ᶵ⬟ࡣ㸪⾜ືⓗᣦᶆẚ㍑ࡋ࡚╀Ẽᙅ࡛࠶ࡿࡇࡀ☜ㄆࡉࢀࡓ㸬ࡋࡓࡀࡗ࡚㸪ࢻࣛࣂ ࣮ᮏேࡼࡿࣃࣇ࢛࣮࣐ࣥࢫࡢほⓗุ᩿ࡸ㸪ࡸࡿẼ࣭ດຊ㢗ࡽ࡞࠸⤌ࡳసࡾ㸦ࡓ࠼ ࡤ㸪㐠㌿ᡭࡢປാ⎔ቃᩚഛࡸ㸪╀Ẽ᳨ฟᶵᲔࡢᦚ㍕㸧ࡀ㸪㏻Ᏻࡢࡓࡵ㔜せ࡛࠶ࡿ࠸ ࠼ࡿ㸬 12 / 32 ➨ ❶ ⮫ᗋ㐃⥆◊✲ ⫼ᬒ ᖺ㐠㌿ኈࡀ╀ࡗࡓ≧ែࡢࡲࡲ᪂ᖿ⥺ࡀ㉮ࡾ⥆ࡅ㸪ᒸᒣ㥐࡛⥭ᛴṆࡍࡿ࠸࠺௳ ࡀ㉳ࡇࡗࡓ㸬ᚋࡢ᳨ᰝ࡛㸪6$6 ࡀ㐠㌿ኈࡢᒃ╀ࡾࡢཎᅉ࡛࠶ࡿุ᫂ࡋ㸪ࡇࡢ௳ࡢሗ㐨ࢆ ㏻ࡌ࡚㸪᪥ᮏ࡛ 6$6 ࡀᗈࡃㄆ▱ࡉࢀࡿࡼ࠺࡞ࡗࡓ㸬6$6 ࡣࡑࡢྡࡢ㏻ࡾ╧╀୰྾ࡀ Ṇࡍࡿ࠸࠺╧╀㞀ᐖ࡛࠶ࡿ㸬╧╀୰㢖⦾྾ࡀṆࡋ㸪྾㛤ぬ㓰ᛂࢆక࠺ ࡓࡵ㸪ኪ㛫ࡢ╧╀ࡢ㉁ࡀపୗ㸦ὸ࣭ศ᩿㸧ࡋ㸪᪥୰ࡢᙉ࠸╀Ẽࡀᘬࡁ㉳ࡇࡉࢀࡿ㸬 6$6 ᝈ⪅࠾ࡅࡿ⮬ື㌴ࡢᒃ╀ࡾᨾࡢ༴㝤ᛶࡘ࠸࡚ࡣ㸪 ᖺ *HRUJH ࡽࡢሗ࿌ 㸦*HRUJH㸧௨᮶㸪ከᩘࡢ◊✲ࡀ⾜ࢃࢀ࡚ࡁࡓ㸦*HRUJH7UHJHDU㸧㸬6DVVDQL ࡽࡼࡿ࣓ࢱࢼࣜࢩࢫࡢ⤖ᯝ࡛ࡣ㸪6$6 ࡣ㏻ᨾࡢ࢜ࢵࢬẚࢆ 㸦㸣ಙ㢗༊㛫&, 㸧ୖ᪼ࡉࡏࡿࡇࡀ♧ࡉࢀ࡚࠸ࡿ㸦6DVVDQL㸧 㸬ࡋࡋ࡞ࡀࡽᡃࡀᅜ࠾࠸࡚ ࡣ୍⯡ேཱྀẚ㍑ࡋࡓࢥࣥࢺ࣮ࣟࣝࢫࢱࢹࡣ࡞ࡃ㸪26$6 ᝈ⪅ࡢᨾ㛵㐃せᅉࡶ᫂ࡽࡉ ࢀ࡚࠸࡞࠸㸬ᮏ◊✲࡛ࡣࡇࢀࡽࡢⅬࢆ᫂ࡽࡍࡿࡶ㸪ᣢ⥆㝧ᅽ྾⒪ἲ㸦FRQWLQXRXV SRVLWLYHDLUZD\SUHVVXUH&3$3㸧⒪ᚋࡢᨾ㢖ᗘࡘ࠸࡚ࡢ㏣㊧ㄪᰝࢆ⾜ࡗࡓ㸬ࡲࡓ≉ 」ᩘᅇᨾ⤒㦂⪅ࡘ࠸࡚ࡣ㸪≧ࡢ㔜ᗘ࠾ࡼࡧ╀Ẽࡢ⮬ぬࡢ㛵㐃ࡘ࠸᳨࡚ウࡋࡓ㸬 ࡉࡽ㸪26$ ᑐࡍࡿ⒪➨୍㑅ᢥࡣ &3$3 ࡛࠶ࡿࡀ㸪᭰ไົࢆక࠺㏻ᶵ㛵㐠㌿ኈ ࠾࠸࡚ࡣ㸪↹㞧࡞ &3$3 ࢆᣢࡕṌࡁ㸪እฟඛ࡛⏝ࡍࡿࡇࡣ⌧ᐇⓗ࡛࡞࠸㸬ࡇࡢࡇࡽ㸪 ㏆ᖺ㸪⡆౽࡛࠶ࡿ 26$ ⒪ἲ࡛࠶ࡿཱྀ⭍ෆ⨨㸦2UDO$SSOLDQFH2$㸧ࡢࢽ࣮ࢬࡀ㧗ࡲࡗ࡚ ࠸ࡿ㸬2$ ࡣ &3$3 ẚ㍑ࡋ⒪ຠᯝࡀຎࡿࡇࡀࡍ࡛ᣦࡉࢀ࡚࠸ࡿࡀ㸪2$ ࡢ⒪ຠᯝࢆ ⒪๓ண ࡍࡿ᭷ຠࡘ⡆౽࡞᪉ἲࡀ⪃ࡉࢀࢀࡤ㸪&3$3 ࡢ௦ࢃࡾ 2$ ࡢ⏝ࢆ᥎ዡࡍ ࡿ࠺࠼࡛᭷⏝࡞ሗࢆᥦ౪ࡋ࠺ࡿ㸬ࡑࡇ࡛㸪ձ⫧‶ 26$ ᝈ⪅࡛ࡣୗ㢡๓᪉⛣ືࢆ⾜ࡗ࡚ࡶୖ Ẽ㐨㛢ሰᛶࡀᨵၿࡋࡃ࠸ࡇ㸦)HUJXVRQHWDO㸧 㸪ղẼ⟶ෆᤄ⟶ࡢᅔ㞴ᗘࢆ♧ࡍ࣐ ࣛࣥࣃࢳࢫࢥ㸦0DOODPSDWL6FRUH06㸧ࡣཱྀ⭍ෆ㌾⤌⧊㔞ࢆどぬⓗホ౯ࡍࡿ⡆౽࡞ᡭἲ ࡛࠶ࡾ㸪26$ ࡢ㔜ᗘࡢᣦᶆ࡛࠶ࡿ↓྾ప྾ᣦᩘ㸦$SQHD+\SRSQHD,QGH[$+,㸧ࡑࡢ 06 ࡀ┦㛵ࡍࡿࡇ㸪ࡢ Ⅼ╔┠ࡋ㸪 ࠕ⫧‶ࡘ 06 ࡀࡁ࠸ᝈ⪅ཱྀ⭍ෆ⨨ࡢ⒪ຠᯝ ࡀஈࡋ࠸࠸࠺௬ㄝࠖࢆ᳨ドࡋࡓ㸬 ᪉ἲ ㄪᰝᑐ㇟ࡣ㸪26$6JURXS㸸╧╀྾㞀ᐖࢡࣜࢽࢵࢡࢆཷデࡋ㸪⤊ኪ࣏ࣜࢯ࣒ࣀࢢࣛࣇ ࡼࡾ☜ᐃデ᩿ࢆᚓࡓ 26$6 ⏨ᛶᝈ⪅ ྡ㸦ᖹᆒs6's ṓ㸧&RQWUROJURXS㸸 ᖺ㱋ࢆ࣐ࢵࢳࣥࢢࡉࡏࡓᮾி㒔ෆࡢ୍⯡⏨ᛶࢻࣛࣂ࣮ ྡࡋࡓ㸬 ࢝ࣝࢸ࠾ࡼࡧ㉁ၥ⚊ࡽ㸪㐣ཤ ᖺ㛫࠾ࡅࡿ㐠㌿ᨾࡢ᭷↓࠾ࡼࡧᅇᩘ㸪㐣ཤ ᖺ࠾ ࡅࡿᒃ╀ࡾ㐠㌿ࡢ᭷↓㸪⒪๓ࡢ࢚ࣉ࣮࣡ࢫ╀Ẽホ౯ᑻᗘᚓⅬ㸦(66㸧 㸪↓྾ప྾ᣦᩘ㸦$+,㸧㸪 %0,㸪ᬑẁࡢ╧╀㛫ࡢࢹ࣮ࢱࢆྲྀᚓࡋࡓ㸬 ཱྀ⭍ෆ⨨ࡢ᳨ウ㛵ࡋ࡚ࡣ㸪╧╀⥲ྜࢣࢡࣜࢽࢵࢡ௦ࠎᮌ࠾࠸ཱྀ࡚⭍ෆ⨨⒪ࢆ 㛤ጞࡋ㸪ຠᯝุᐃࡢࡓࡵࡢ⤊ኪ࣏ࣜࢢࣛࣇ᳨ᰝ㸦36*㸧ࢆ⾜ࡗࡓ 26$ ୰➼ ྡ㸦⏨ᛶࡢ ࡳ㸧ࢆᑐ㇟ࡋࡓ㸬ึデ⫧‶ᗘ%RG\0DVV,QGH[%0,࡞ࡽࡧ࣐ࣛࣥࣃࢳࢫࢥ 13 / 32 㸦0DOODPSDWL6FRUH06㸧ࢆṑ⛉་ᖌࡀグ㘓ࡋ㸪ࡑࡢᚋཱྀ⭍ෆ⨨ࢆ╔ࡋࡓ㸦ᅗ 㸧㸬 06 ࡣ㸪ᗙ࡛ኌࢆฟࡉࡎ᭱㛤ཱྀࡋ㸪⯉ࢆ᭱๓✺ࡋࡓ㝿ࡢཱྀᆶࡢぢ࠼᪉࡛㸪,㹼,9 㢮ศ㢮ࡍࡿ1XFNWRQHWDO㸹 , 㢮㸸ཱྀᆶࡀぢ࠼ࡿ㸪,, 㢮㸸ཱྀᆶࡢඛ➃ࡀぢ ࠼࡞࠸㸪,,, 㢮㸸ཱྀᆶࡢᇶ㒊ࡀࢁ࠺ࡌ࡚ぢ࠼ࡿ㸪,9 㢮㸸ཱྀᆶࡀࡃぢ࠼࡞࠸ᅗ 㸬 ᅗ ཱྀ⭍ෆ⨨ࡢ୍ ᅗ ࣐ࣛࣥࣃࢳࢫࢥ ࡑࡢᚋ㸪ୗ㢡ࡢ๓᪉ㄪ⠇ࢆ⤊ࡋࡓⅬ࠾࠸࡚㸪2$ ╔ୗ࡚ 36* ࡢ᥇ᚓࢆᗘ⾜ࡗ ࡓ㸬ࡲࡓ㸪26$ ᝈ⪅ࢆ⒪ᛂ⩌⒪ᚋ $+,ࡘึデ $+, ࡢ ௨ୖῶᑡ㸪⒪㠀 ᛂ⩌㸦⒪ᚋ $+,! ࡲࡓࡣึデ $+, ࡢ ᮍ‶ࡢᨵၿ㸧ศ㢮ࡋࡓ㸬%0, 㛵ࡍࡿ 5HFHLYHU 2SHUDWRU&KDUDFWHULVWLF52&᭤⥺ࢆసᡂࡋ㸪%0, ࡼࡿ⒪ຠᯝ᳨ฟຊࡢ᳨ウ⮳㐺࢝ࢵ ࢺ࢜ࣇ್ࡢྠᐃࢆ⾜ࡗࡓ㸬 ⤖ᯝ 㐣ཤ ᖺ㛫࡛ࡢ㏻ᨾ㛵㐃ࡍࡿせᅉࢆࡘ࠸࡚㸪ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࢆ⏝࠸᳨࡚ ウࡋࡓࡇࢁ㸪⮬ぬⓗ࡞╀Ẽࡢ㧗ࡉ㸦(66 ᚓⅬࡀ Ⅼ௨ୖࡢ㔜ᗘࡢ╀Ẽࡢ࠶ࡿ⪅ࡣ㏻ᨾ ࣜࢫࢡࡀ ಸ㸧 ↓྾ࡢ㔜ᗘᣦᩘ㸦$+, ࡀ ௨ୖࡢ㔜⪅ࡣ㏻ᨾࣜࢫࢡࡀ ಸ㸧 ࡀᢳฟࡉࢀࡓ㸬ᖺ㱋㏻ᖖࡢ╧╀㛫ࡣ᭷ព࡞㛵㐃せᅉ࡛ࡣ࡞ࡗࡓ㸦⾲ 㸧 㸬 ⾲ ̾ 㐣ཤ ᖺ㛫࠾ࡅࡿ㏻ᨾⓎ⏕ࡢ㛵㐃せᅉ 㼀㼛㼠㼍㼘 㼚 㻭㼓㼑 㻌㻌㻌㻌㻨㻠㻣 㻟㻜㻡 㻌㻌㻌㻌䍹㻠㻣 㻟㻝㻝 㼁㼟㼡㼍㼘㻌㼟㼘㼑㼑㼜㻌㼘㼑㼚㼓㼠㼔 㻌㻌㻌㻌㻨㻣㼔㼞 㻟㻝㻞 㻌㻌㻌㻌䍹㻣㼔㼞 㻞㻥㻢 㻖㻞 㻱㻿㻿㻌㼟㼏㼛㼞㼑 㻌㻌㻌㻌㻨㻝㻝 㻞㻡㻢 㻌䚷㻌䍹㻝㻝㻘㻌㻨㻝㻢 㻞㻞㻤 㻌䚷㻌䍹㻝㻢 㻝㻟㻞 㻭㻴㻵㻖㻟 㻌㻌㻌㻌㻨㻠㻜 㻞㻥㻣 㻌㻌䚷䍹㻠㻜 㻟㻝㻥 㼚 㻌㻹㼂㻭 㻑 㼁㼚㼕㼢㼍㼞㼕㼍㼠㼑㻌㻾㼑㼘㼍㼠㼕㼢㼑 㻖㻝 㻾㼕㼟㼗㻌㻔㻥㻡㻑㻌㻯㻵㻕 㻼 㻹㼡㼘㼠㼕㼢㼍㼞㼕㼍㼠㼑㻌㻾㼑㼘㼍㼠㼕㼢㼑 㻾㼕㼟㼗㻌㻔㻥㻡㻑㻌㻯㻵㻕 㻼 㻟㻥 㻟㻢 㻝㻞㻚㻤 㻝㻝㻚㻢 㼚㼟 㼚㼟 㻟㻣 㻟㻣 㻝㻝㻚㻥 㻝㻞㻚㻡 㼚㼟 㼚㼟 㻝㻣 㻞㻤 㻟㻜 㻢㻚㻢 㻝㻞㻚㻟 㻞㻞㻚㻣 㻝㻚㻥㻣 㻠㻚㻝㻠 䠄 㻝㻚㻜㻡㻙㻟㻚㻣㻜 䠅 㻨㻜㻚㻜㻡 䠄 㻞㻚㻝㻤㻙㻣㻚㻤㻟 䠅 㻨㻜㻚㻜㻜㻜㻝 㻝㻚㻤㻣 㻟㻚㻡㻢 䠄 㻜㻚㻥㻥㻙㻟㻚㻡㻟 䠅 㻩㻜㻚㻜㻡 䠄 㻝㻚㻤㻡㻙㻢㻚㻤㻠 䠅 㻨㻜㻚㻜㻜㻝 㻞㻠 㻡㻝 㻤㻚㻝 㻝㻢㻚㻜 㻞㻚㻝㻣 䠄 㻝㻚㻟㻜㻙㻟㻚㻢㻞 䠅 㻨㻜㻚㻜㻡 㻝㻚㻣㻡 䠄 㻝㻚㻜㻟㻙㻞㻚㻥㻤 䠅 㻨㻜㻚㻜㻡 㻖㻝 㻾㼑㼘㼍㼠㼕㼢㼑㻌㼞㼕㼟㼗㼟㻌㼍㼜㼜㼞㼛㼤㼕㼙㼍㼠㼑㼐㻌㼣㼕㼠㼔㻌㼛㼐㼐㼟㻌㼞㼍㼠㼕㼛㼟㻚㻌㻯㻵㻌㼐㼑㼚㼛㼠㼑㼟㻌㼏㼛㼚㼒㼕㼐㼑㼚㼏㼑㻌㼕㼚㼠㼑㼞㼢㼍㼘㼟 㻱㼜㼣㼛㼞㼠㼔㻌㻿㼘㼑㼑㼜㼕㼚㼑㼟㼟㻌㻿㼏㼍㼘㼑㻌㼎㼑㼒㼛㼞㼑㻌㼠㼞㼑㼍㼠㼙㼑㼚㼠 㻖㻟 㻭㼜㼚㼑㼍㻌㼔㼥㼜㼛㼜㼚㼑㼍㻌㼕㼚㼐㼑㼤㻌㼎㼑㼒㼛㼞㼑㻌㼠㼞㼑㼍㼠㼙㼑㼚㼠 㻖㻞 14 / 32 㐣ཤ ᖺ࠾ࡅࡿᒃ╀ࡾ㐠㌿㛵ࡋ࡚ࡣ㸪⮬ぬⓗ࡞╀Ẽࡢ㧗ࡉ㸦(66 ᚓⅬࡀ Ⅼ௨ୖࡢ୰ ➼ᗘࡢ╀Ẽࡢ࠶ࡿ⪅࡞ࡽࡧ Ⅼ௨ୖࡢ㔜ᗘࡢ╀Ẽࡢ࠶ࡿ⪅ࡣᒃ╀ࡾ㐠㌿ࣜࢫࢡࡀࡑࢀࡒ ࢀ ಸ㸪 ಸ㸧↓྾ࡢ㔜ᗘᣦᩘ㸦$+, ࡀ ௨ୖࡢ㔜⪅ࡣᒃ╀ࡾ㐠㌿ࣜࢫࢡࡀ ಸ㸧ࡀ᭷ព࡞㛵㐃ᅉᏊ࡛࠶ࡗࡓ㸦⾲ 㸧 㸬 ⾲ ̾ 㐣ཤ ᖺ㛫࠾ࡅࡿᒃ╀ࡾ㐠㌿Ⓨ⏕ࡢ㛵㐃せᅉ 㻌㼐㼛㼦㼕㼚㼓㻌㼛㼒㼒 㼀㼛㼠㼍㼘 㼍㼠㻌㼠㼔㼑㻌㼣㼔㼑㼑㼘 㼚 㼚 㻑 㻭㼓㼑 㻌㻌㻌㻌㻨㻠㻣 㻟㻜㻡 㻌㻌㻌㻌䍹㻠㻣 㻟㻝㻝 㼁㼟㼡㼍㼘㻌㼟㼘㼑㼑㼜㻌㼘㼑㼚㼓㼠㼔 㻌㻌㻌㻌㻨㻣㼔㼞 㻟㻝㻞 㻌㻌㻌㻌䍹㻣㼔㼞 㻞㻥㻢 㻖㻞 㻱㻿㻿㻌㼟㼏㼛㼞㼑 㻌㻌㻌㻌㻨㻝㻝 㻞㻡㻢 㻞㻞㻤 㻌䚷㻌䍹㻝㻝㻘㻌㻨㻝㻢 㻌䚷㻌䍹㻝㻢 㻝㻟㻞 㻖㻟 㻭㻴㻵 㻌㻌㻌㻌㻨㻠㻜 㻞㻥㻣 㻌㻌䚷䍹㻠㻜 㻟㻝㻥 㼁㼚㼕㼢㼍㼞㼕㼍㼠㼑㻌㻾㼑㼘㼍㼠㼕㼢㼑 㻾㼕㼟㼗㻌㻔㻥㻡㻑㻌㻯㻵㻕㻖㻝 㻼 㻹㼡㼘㼠㼕㼢㼍㼞㼕㼍㼠㼑㻌㻾㼑㼘㼍㼠㼕㼢㼑 㻾㼕㼟㼗㻌㻔㻥㻡㻑㻌㻯㻵㻕 㻼 㻝㻤㻣 㻝㻢㻥 㻢㻝㻚㻟 㻡㻠㻚㻟 㼚㼟 㼚㼟 㻝㻣㻢 㻝㻣㻠 㻡㻢㻚㻠 㻡㻤㻚㻤 㼚㼟 㼚㼟 㻤㻥 㻝㻡㻠 㻝㻝㻟 㻟㻠㻚㻤 㻢㻣㻚㻡 㻤㻡㻚㻢 㻟㻚㻥㻝 㻝㻝㻚㻝㻢 䠄 㻞㻚㻢㻤㻙㻡㻚㻣㻜 䠅 㻨㻜㻚㻜㻜㻜㻝 䠄 㻢㻚㻠㻠㻙㻝㻥㻚㻟㻠 䠅 㻨㻜㻚㻜㻜㻜㻝 㻟㻚㻣㻥 㻥㻚㻤㻣 䠄 㻞㻚㻡㻥㻙㻡㻚㻡㻡 䠅 㻨㻜㻚㻜㻜㻜㻝 䠄 㻡㻚㻢㻢㻙㻝㻣㻚㻞㻞 䠅 㻨㻜㻚㻜㻜㻜㻝 㻝㻠㻟 㻞㻝㻟 㻠㻤㻚㻝 㻢㻢㻚㻤 㻞㻚㻝㻢 䠄 㻝㻚㻡㻢㻙㻟㻚㻜㻜 䠅 㻨㻜㻚㻜㻜㻜㻝 㻝㻚㻢㻤 䠄 㻝㻚㻝㻤㻙㻞㻚㻠㻜 䠅 㻨㻜㻚㻜㻝 㻖㻝 㻾㼑㼘㼍㼠㼕㼢㼑㻌㼞㼕㼟㼗㼟㻌㼍㼜㼜㼞㼛㼤㼕㼙㼍㼠㼑㼐㻌㼣㼕㼠㼔㻌㼛㼐㼐㼟㻌㼞㼍㼠㼕㼛㼟㻚㻌㻯㻵㻌㼐㼑㼚㼛㼠㼑㼟㻌㼏㼛㼚㼒㼕㼐㼑㼚㼏㼑㻌㼕㼚㼠㼑㼞㼢㼍㼘㼟 㻱㼜㼣㼛㼞㼠㼔㻌㻿㼘㼑㼑㼜㼕㼚㼑㼟㼟㻌㻿㼏㼍㼘㼑㻌㼎㼑㼒㼛㼞㼑㻌㼠㼞㼑㼍㼠㼙㼑㼚㼠 㻖㻟 㻭㼜㼚㼑㼍㻌㼔㼥㼜㼛㼜㼚㼑㼍㻌㼕㼚㼐㼑㼤㻌㼎㼑㼒㼛㼞㼑㻌㼠㼞㼑㼍㼠㼙㼑㼚㼠 㻖㻞 ㏻ᨾࡢᅇᩘ 6$6 㔜ᗘࡢ㛵ಀࢆ᳨ウࡋࡓ㸬ᨾࢆ㉳ࡇࡋࡓࡇࡢ࡞࠸⪅㸪㐣ཤ ᖺ㛫 ᅇ㉳ࡇࡋࡓࡇࡀ࠶ࡿ⪅㸪 ᅇ௨ୖࡢ⪅ศ㢮ࡋ࡚㸪 ⩌㛫࡛ $+, (66 ẚ㍑ࡋࡓ ࡇࢁ㸪ᨾࡀ ᅇ௨ୖࡢ⪅ࡣ㸯ᅇࡢ⪅ẚ࡚㸪$+, ࡣ᭷ព㧗ࡗࡓ㸬୍᪉㸪(66 ࡣ᭷ព పࡃ㸪྾㞀ᐖࡀ㔜࡞╀Ẽࡢ⮬ぬࡀ㕌ࡋ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡓ㸦ᅗ 㸧 㸬 Group without MVA: n = 496, Group with one episode of MVA: n = 56, Group with twice or more of MVAs: n = 18 AHI: F2, 567 = 7.2, P < 0.001; ESS: F2, 567 = 15.9, P < 0.0001 ᅗ ㏻ᨾࡢᅇᩘูࡳࡓ $+,㸦ᕥᅗ㸧 (66 ᚓⅬ㸦ྑᅗ㸧 15 / 32 㰯⭍ᣢ⥆㝧ᅽ྾ἲ㸦FRQWLQXRXVSRVLWLYHDLUZD\SUHVVXUH&3$3㸧⒪ࢆ㛤ጞࡍࡿ㸪 ᨾ⋡ࡣ᭷ពῶᑡࡋࡓ㸬㏻ᨾ⋡ࡣ⒪๓ 㸣࡛࠶ࡗࡓࡀ㸪⒪ᚋࡣ 㸣ῶᑡࡋ 㸦S㸧㸪ࢥࣥࢺ࣮ࣟࣝ⩌ࡢ㏻ᨾ⋡ྠỈ‽࡛࠶ࡗࡓ㸦ᅗ 㸧 㸬 4.7% Control 16.8%** OSAS, Pre-CPAP treatment OSAS, Post-CPAP treatment 3.1% 0% 5% MVA 10% Yes 15% 20% 25% 30% No ᅗ 㐣ཤ ᖺ㛫࠾ࡅࡿ㏻ᨾⓎ⏕ྜ 㸫ࢥࣥࢺ࣮ࣟࣝ⩌ 26$6 ᝈ⪅⩌⒪๓ᚋࡢẚ㍑㸫 ཱྀ⭍ෆ⨨ࡢ᳨ウ㛵ࡋ࡚ࡣ㸪ึデ $+, ࡣ sKUWRsKU᭷ពῶᑡࡋࡓ S㸬 ྡ୰㸪 ྡࡀ⒪ᛂ⪅ุ᩿ࡉࢀࡓ㸦⾲ 㸧 㸬 ⾲ 26$ ᑐࡍࡿཱྀ⭍ෆ⨨ࡢ⒪ຠᯝ Diagnostic Characteristics Subjects (%) Age yrs BMI kg/m2 Mallampati Score ESS AHI baseline /hr AHI follow-up /hr Responders Non-responders Total 35 (37) 45±9 23±3 # 2.7±0.9 # 13±5 # 21±5 2±2 ##,** 60 (63) 44±10 26±4 3.2±1.0 11±5 20±4 13±8 ** 95 45±10 25±4 3.0±1.0 12±5 21±4 9±8 ** Responders were defined as patients who showed a follow-up Apnea Hypopnoea Index (AHI) of <5 events h-1 with a >50% reduction compared to the baseline AHI. BMI = Body Mass Index. ESS = Epworth Sleepiness Scale. Values are expressed as the mean ± standard deviation. *: p<0.05 versus baseline; **: p<0.01 versus baseline; #: p<0.05 versus non-responder; ##: p<0.01 versus non-responder. ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࡢ⤖ᯝ㸪06 %0, ࡣ 2$ ࡢ⒪ຠᯝࢆண ࡍࡿ࠺࠼࡛ࡢ⊂❧ࡋࡓ ᅉᏊ࡛࠶ࡿࡇࡀุ᫂ࡋࡓ㸦⾲ 㸧 㸬 16 / 32 ⾲ ࣟࢪࢫࢸࢵࢡᅇᖐศᯒࡼࡿ 26$ ୰➼1 ࡢཱྀ⭍ෆ⨨⒪ຠᯝண Diagnostic Characteristics Univariate model Age BMI Mallampati score AHI baseline Multivariate model BMI Mallampati score Odds ratio 95%CI p-value 0.99 0.82 0.55 1.10 0.95-1.04 0.71-0.96 0.34-0.89 0.98-1.22 0.70 0.01* 0.02* 0.10 0.83 0.61 0.72-0.97 0.38-0.97 0.02* 0.04* BMI = Body Mass Index. Increases in both BMI and the Mallampati score are Data are presented as the odds ratio and 95% confidence interval (CI). AHI = Apnea Hypopnea Index. *: p<0.05. significantly more likely to be associated with treatment failure with an oral appliance in patients with moderate OSA. ḟ㸪%0, 㛵ࡍࡿ 52& ᭤⥺ࡽỴᐃࡉࢀࡓ⮳㐺࢝ࢵࢺ࢜ࣇ್࡛࠶ࡿ NJP ╔┠ࡋࡓ ࡇࢁ㸦⾲ 㸧 㸪⫧‶⪅%0,!NJPࡘ 06 ࡀ ,9 㢮࡛࠶ࡿ ྡࡢ㝜ᛶⓗ୰⋡ࡣ 㸪ࡉࡽ 㝜ᛶᑬᗘẚࡣ ࡛࠶ࡗࡓ⾲ 㸬 ⾲ ࣐ࣛࣥࣃࢳࢫࢥ⫧‶ᗘ╔┠ࡋࡓཱྀ⭍ෆ⨨ࡢ⒪⤖ᯝ A Responders Non-responders Total Mallampati score Some airway visible No airway visible Total 28 7 35 26 34 60** 54 41 95 Obesity Non-obese Obese 22 13 20 40 42 53 35 60xx 95 B Obesity Mallampati score Non-Obese Some airway visible No airway visible Total 17 5 22 8 12 20# 25 17 42 Obese Some airway visible No airway visible Total 11 2 13 18 22 40$ 29 24 53 Responders Non-responders Total Some airway visible = Mallampati score of Class I to III, No airway visible = Mallampati score of Class IV, Non-obese = body mass index < 24 kg/m2, Obese = body mass index > 24 kg/m2. Note that the obesity cut-off in this study was determined by a receiver-operating characteristic curve. **: <ates ǘ2 =10.7, p<0.01 versus responders, : ǘ2 =7.81, p<0.01 versus responders, #: <ates ǘ2 =4.59, p<0.05 versus responders, : <ates ǘ2 =4.72, p<0.05 versus responders. 17 / 32 ⾲ ࣐ࣛࣥࣃࢳࢫࢥ⫧‶ᗘࡼࡿཱྀ⭍ෆ⨨ࡢ⒪ຠᯝண Prediction Variable Mallampati score Obesity Mallampati score & Non-obese (N=42) Mallampati score & Obese (N=53) Sensitivity Specificity PPV NPV LR+ LR- 80 57 52 83 1.85 0.35 63 67 52 75 1.89 0.56 77 60 68 71 1.93 0.38 85 55 38 92 1.88 0.28 Non-obese = body mass index < 24 kg/m2, Obese = body mass index > 24 kg/m2. PPV = positive predictive value; NPV = negative predictive value. LR+ = positive likelihood ratio; LR- = negative likelihood ratio. ⪃ᐹ ᾏእ࡛ࡢ◊✲࡛ࡣ㸪6$6 ᝈ⪅࠾ࡅࡿ㏻ᨾࣜࢫࢡࡢୖ᪼ࡀᣦࡉࢀ࡚ࡁࡓ 㸦<RXQJHWDO 㸧 㸬╧╀ࡢ྾㞀ᐖࢆᣢࡗ࡚࠸ࡿேࡣ㸪ࡑ࠺࡛࡞࠸ேẚ㍑ࡋ࡚㸪㐣ཤ ᖺ㛫࠾࠸࡚ ᑡ࡞ࡃࡶ ᅇࡢ㏻ᨾࢆ㉳ࡇࡋࡓ☜⋡ࡀ 㹼 ಸ㐩ࡍࡿሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡉࡽ 」ᩘᅇࡢᨾࢆ ᖺ㛫㉳ࡇࡍ☜⋡ࢆࡳࡿ㸪྾㞀ᐖࢆᣢࡓ࡞࠸ேẚ㍑ࡋ࡚㸪୰➼ᗘ௨ ୖ㸦$+,!㸧ࡢ྾㞀ᐖࢆᣢࡘே࡛ࡣ ಸ࡞ࡿ㸬ᅇ㸪ࢃࢀࢃࢀࡢ⤖ᯝࡽࡣ㸪ᖖ⪅ ࡢ㏻ᨾ⤒㦂ྜࡀ 㸣࡛࠶ࡿࡢᑐࡋ࡚㸪⒪๓ࡢ 6$6 ᝈ⪅࡛ࡣ 㸣 ಸ௨ୖ ࡞ࡗ࡚࠸ࡓ㸬ࡋࡋ &3$3 ⒪ᚋ࡛ࡣ㸪ᖖ⪅ኚࢃࡽ࡞࠸ࣞ࣋ࣝࡲ࡛㏻ᨾ⤒㦂ྜࡀ పୗࡋ࡚࠸ࡓ㸬㏻ᨾࢆ」ᩘᅇ㉳ࡇࡋࡓࢻࣛࣂ࣮࡛ࡣ㸪྾㞀ᐖࡢ⛬ᗘࡣ᭷ព㧗࠸୍ ᪉㸪⮬ぬⓗ࡞╀Ẽࡣ᭷ពపࡃ࡞ࡗ࡚࠸ࡓ㸬ࡍ࡞ࢃࡕ㸪྾㞀ᐖࡀ㔜࡞╀Ẽࡢ⮬ぬࡀ 㕌ࡋ࡚࠸ࡿࡇࢆ♧၀ࡍࡿࡶࡢ࡛࠶ࡗࡓ㸬௨ୖࡼࡾ㸪㏻ᨾ㜵ṆࡢほⅬࡽ㔜 6$6 ᝈ ⪅ࡢ᪩ᮇⓎぢࡢ㔜せᛶࡀ☜ㄆࡉࢀ㸪≉྾㞀ᐖ㢖ᗘࡢ㧗࠸ࡘ࠸࡚ࡣ㸪⮬ぬⓗ╀Ẽ ࡢ᭷↓ࡼࡽࡎ᪩ᮇ⒪㛤ጞࡍࡿᚲせࡀ࠶ࡿุ᩿ࡉࢀࡓ㸬 ࡲࡓ㸪ཱྀ⭍ෆ⨨ࡢ᳨ウ㛵ࡋ࡚ࡣ㸪ᙜึࡢ௬ㄝ㏻ࡾ⫧‶ࡘ 06 ࡀ ,9 㢮࡛࠶ࡿሙྜ㸪2$ ࡢ⒪ຠᯝࢆᮇᚅࡋ㞴࠸ࡇࡀุ᫂ࡋࡓ㸬ゝ࠸࠼ࡿ࡞ࡽࡤ㸪ࡇࢀࡽࡢ᮲௳ࢆ‶ࡓࡉ࡞࠸ࠕ⑭ ࡏᆺࡘཱྀᆶࡀぢ࠼ࡸࡍ࠸㸦06 ࡀ ,,,,㢮㸧ᝈ⪅ᑐࡋ㸪✚ᴟⓗ 2$ ࡢ⏝ࢆ່ࡵࡿ ࡇࡀྍ⬟࡛ࠖ࠶ࡾ㸪2$ ࡣ &3$3 ࡢ௦᭰⒪ἲ࡞ࡾ࠺ࡿ7VXLNLHWDO㸬௨ୖࡢ⤖ᯝ ࡣ㸪㏻ᶵ㛵㐠㌿ኈࡢ㐣╀ࢆࡣࡌࡵࡍࡿ 26$ ≧ࢆ㐺ษࢥࣥࢺ࣮ࣟࣝࡍࡿ࠺࠼࡛㔜せ࡞ ሗ࡞ࡿ⪃࠼ࡽࢀࡓ㸬 18 / 32 ➨ ❶ Ꮫ◊✲ ⫼ᬒ ⌧௦ேࡢ⏕άࡣ㸪ࡸፗᴦࡢᘏ㛗࡛ኪᆺࡘつ๎ࡀ㐍ࢇ࡛࠸ࡿ㸬1+. ᅜẸ⏕ά 㛫ㄪᰝࡼࡿ㸪 ௨㝆㉳ࡁ࡚࠸ࡿ⪅ࡢྜࡣ⃭ቑࡋ㸪᪥ᮏேࡢ╧╀㛫ࡣ㐣ཤ ᖺ ࡢ㛫㸯㛫㏆ࡃῶᑡࡋࡓ㸦1+. ᅜẸ㛫⏕άㄪᰝᅗ 㸬ࡇࡢࡼ࠺࡞ࣛࣇࢫࢱࣝࡢ ኚࡣ☜ᐇ╧╀ၥ㢟ࡢቑຍࡢཎᅉ࡞ࡗ࡚࠸ࡿ㸦2KLGDHWDO㸧 㸬≉╧╀㊊ࡣ㸪 ᪥୰ࡢぬ㓰Ỉ‽ࢆపୗࡉࡏ㸪సᴗ࢚࣮ࣛࡶࡋࡃࡣ㐠㌿ᨾࡢࣜࢫࢡࢆୖ᪼ࡉࡏࡿྍ⬟ᛶࡀ㧗 ࠸㸦/HJHU5RHKUVHWDO㸬 ᅗ ᪥ᮏேࡢ╧╀㛫ኪᆺࡢ᥎⛣ ᖺࡢ᪥ᮏேࡢᖹ᪥ᖹᆒ╧╀㛫ኪ ㉳ࡁ࡚࠸ࡿ⪅ࡢ ྜࢆ♧ࡋࡓ㸬 ᖺࡣኪ ࡣ ࡢᅜẸࡀᑵᗋࡋ࡚࠾ࡾ㸪 ╧╀㛫ࡣ 㛫ࢆ㉸࠼࡚࠸ࡓࡀ㸪ᖺࢆ⤒ࡿࡈኪᆺ╧╀㛫ࡢ ▷⦰ࡀ㐍ࡳ㸪 ᖺ࡛ࡣኪ ࡣ༙ᩘࡢ⪅ࡀ㉳ࡁ࡚࠾ࡾ㸪ᖹᆒ╧╀ 㛫ࡣ 㛫 ศ࡛࠶ࡿ㸬 㸦1+. ᅜẸ㛫⏕άㄪᰝࡼࡾసᡂ㸧 ៏ᛶⓗ࡞╧╀㊊ᇶ࡙࠸࡚᪥୰ࡢ╀Ẽࢆ⏕ࡌࡿ⾜ືㄏⓎᛶ╧╀㊊ೃ⩌㸦%HKDYLRUDO ,QVXIILFLHQW VOHHS V\QGURPH%,,66㸧ࡣ㸪╧╀㞀ᐖᅜ㝿デ᩿ศ㢮➨∧㸦,&6'㸧࠾ ࠸࡚㐣╀≧ࢆ࿊ࡍࡿᝈ༢ࡋ࡚⨨࡙ࡅࡽࢀ࡚࠸ࡿ㸦$PHULFDQ$FDGHP\RI6OHHS 0HGLFLQH㸧㸬᪥୰㐣ᗘࡢ╀Ẽࢆッ࠼㸪ᒃ╀ࡾࢆ⧞ࡾ㏉ࡍᝈ⪅ࡢ୰ࡣ㸪ࢼࣝࢥࣞࣉࢩ ࣮࡛ࡶⓗ࡞╧╀ศ᩿࡛ࡶ࡞ࡃ╧╀㛫ࡀ៏ᛶⓗ▷࠸⪅ࡀᑡ࡞ࡽࡎᏑᅾࡋ㸪ᾏእࡢሗ࿌ ࡛ࡣ㸪╧╀㞀ᐖࢭࣥࢱ࣮ࢆゼࢀࡿᝈ⪅ࡢ⣙ 㸣㸪᪥୰ࡢ㐣࡞╀Ẽࢆッ࠼ࡿᝈ⪅ࡢ 㸣ࡀ⾜ ືㄏⓎᛶ╧╀㊊ೃ⩌࡛࠶ࡿሗ࿌ࡉࢀ࡚࠸ࡿ㸦5RHKUVHWDO㸬ᡃࠎࡀ㐣ཤᐇ ࡋࡓㄪᰝ࡛ࡣ㸪᪥୰ࡢ㐣࡞╀Ẽࢆッࡋ࡚ཷデࡋࡓᝈ⪅ ྡࡢ࠺ࡕ㸪⾜ືㄏⓎᛶ 19 / 32 ╧╀㊊ೃ⩌デ᩿ࡉࢀࡓ⪅ࡢྜࡣ 㸣࡛࠶ࡗࡓ㸦.RPDGDHWDO㸧 㸬ࡇࢀࡣ㸪 ╧╀↓྾ೃ⩌㸪≉Ⓨᛶ㐣╀㸪ࢼࣝࢥࣞࣉࢩ࣮࡞ࡢ௦⾲ⓗ࡞㐣╀ᛶᝈḟࡄࡶࡢ ࡛࠶ࡾ㸪ᴫ᪥ࣜࢬ࣒╧╀㞀ᐖࡸ࿘ᮇᛶᅄ⫥㐠ື㞀ᐖࡼࡾࡶ㧗Ỉ‽࡛࠶ࡗࡓ㸦⾲ 㸧 㸬ࡇࡢࡇ ࡽࡳ࡚㸪៏ᛶⓗ࡞╧╀㊊ࡀ᪥୰ࡢ㐣࡞╀Ẽࡢཎᅉ࡞ࡗ࡚࠸ࡿࢣ࣮ࢫࡣ↓ど࡛ࡁ࡞ ࠸ࡶࡢᛮࢃࢀࡿ㸬ࡲࡓ㸪୍⯡ேཱྀ࠾ࡅࡿ៏ᛶ╀Ẽࡢᐇែࡽࡳ࡚㸪╧╀㊊ࡀ⏕ࡌ࡚ࡶ ་⒪ᶵ㛵ࢆཷデࡋ࡞࠸⪅ࡀከᩘ࡛࠶ࡿࡇࡣ☜ᐇ࡛࠶ࡾ㸪⾜ືㄏⓎᛶ╧╀㊊ೃ⩌ணഛ ㌷ࡶ࠸࠺ࡁ₯ᅾⓗᝈ⪅ࡀከࡃᏑᅾࡍࡿᛮࢃࢀࡿ㸬 ⾲ ᪥୰㐣╀ࢆッࡋ࡚ཷデࡋࡓᝈ⪅ࡢෆヂ㸦Q 㸧 ⾜ືㄏⓎᛶ╧╀㊊ೃ⩌ࡢ≧ࡋ࡚㸪⑂ປ㸪࠸ࡽ࠸ࡽ㸪ᢚ࠺ࡘ㸪➽⫗ࡢ③ࡳ㸪㞟୰ᅔ 㞴㸪ㄆ▱ᶵ⬟ࡢపୗ㸪ぬ㓰ᗘࡢపୗ࡞ࡀⓎ⌧ࡍࡿྍ⬟ᛶࡢ࠶ࡿࡇࡀᣦࡉࢀ࡚࠾ࡾ 㸦$OGULFK%URPDQHWDO㸧 㸪≉ὀពຊࡸぬ㓰ᗘࢆᚲせࡍࡿㄢ㢟ࡢᡂ⦼ࡀప ୗࡍࡿࡇࡀ☜ㄆࡉࢀ࡚࠸ࡿ㸦5RHKUVHWDO㸧 㸬ᡃࠎࡢ◊✲࡛ࡣ㸪⾜ືㄏⓎᛶ╧╀ ㊊ೃ⩌ࡢึデ࠾ࡅࡿ (66 ᚓⅬࡣ s Ⅼ࡛࠶ࡾ㸪࢝ࢵࢺ࢜ࣇ್ࡢ Ⅼࢆୖᅇࡗ࡚ ࠸ࡓ㸦.RPDGDHWDO㸧 㸬ࡇࢀࡣ㸪ࢼࣝࢥࣞࣉࢩ࣮ࡢࡑࢀࡼࡾ᭷ពప࠸ࡶࡢࡢ㸪╧╀ ↓྾ೃ⩌ᴫ᪥ࣜࢬ࣒╧╀㞀ᐖࡼࡾࡣ᭷ព㧗࠸ᚓⅬ࡛࠶ࡾ㸪≉Ⓨᛶ㐣╀ྠỈ‽ ࡛࠶ࡿ㸦⾲ 㸧 㸬 20 / 32 ⾲ せ㐣╀ ᝈ࡛ࡢ⮫ᗋ⫼ᬒࡢẚ㍑ デ᩿ྡ ึデᖺ㱋 㻹㼑㼍㼚 㻿㻰 ╧╀㊊ೃ⩌䠄㻮㻵㻵㻿㻿䠅 㻟㻜㻚㻞 㻣㻚㻟 ╧╀↓྾ೃ⩌ 㻠㻡㻚㻝 㻝㻞㻚㻝 㻟㻝㻚㻠 㻥㻚㻜 㻟㻝㻚㻜 㻝㻟㻚㻟 㻞㻣㻚㻣 㻤㻚㻝 ≉Ⓨᛶ㐣╀ 䝘䝹䝁䝺䝥䝅䞊 ᴫ᪥䝸䝈䝮╧╀㞀ᐖ 㻖㻖㻖 㻝㻕 Ⓨᖺ㱋㻌 ึデ㻱㻿㻿ᚓⅬ 㻹㼑㼍㼚 㻿㻰 㻹㼑㼍㼚 㻿㻰 㻞㻤㻚㻢 㻙 㻝㻥㻚㻞 㻝㻣㻚㻞 㻝㻤㻚㻥 㻝㻟㻚㻢 㻝㻞㻚㻡 㻝㻠㻚㻟 㻝㻡㻚㻣 㻝㻞㻚㻠 㻣㻚㻡 㻙 㻣㻚㻟 㻣㻚㻡 㻢㻚㻠 㻖㻖㻖 㻖㻖㻖 㻖㻖㻖 㻟㻚㻠 㻟㻚㻢 㻟㻚㻜 㻟㻚㻜 㻟㻚㻣 㻌 㻮㻹㻵 㻹㼑㼍㼚 㻿㻰 㻖㻖 㻖㻖㻖 㻖 㻞㻞㻚㻞 㻞㻣㻚㻠 㻞㻝㻚㻤 㻞㻟㻚㻠 㻞㻝㻚㻥 㻞㻚㻤 㻠㻚㻥 㻟㻚㻝 㻠㻚㻝 㻟㻚㻤 ᖹ᪥╧╀㛫 㻹㼑㼍㼚 㻿㻰 㻖㻖㻖 㻖 㻡㻚㻡 㻢㻚㻝 㻢㻚㻟 㻢㻚㻠 㻣㻚㻤 㻜㻚㻤 㻝㻚㻜 㻝㻚㻝 㻝㻚㻟 㻞㻚㻟 㻖㻖㻖 㻖㻖㻖 㻖㻖㻖 㻖㻖㻖 㻖㻖㻖㻦㻌㼜㻨㻜㻚㻜㻜㻜㻝㻧㻌㻖㻖㻦㻌㼜㻨㻜㻚㻜㻝㻘㻌㻖㻦㻌㼜㻨㻜㻚㻜㻡䠄╧╀㊊ೃ⩌䛸䛾ᚋẚ㍑䠅 㻝㻕 㻌╧╀↓྾ೃ⩌䛷䛿䚸Ⓨᖺ㱋䛜᫂䛾䛯䜑᳨ウ䛧䛺䛛䛳䛯䚹 ࡲࡓ⾜ືㄏⓎᛶ╧╀㊊ೃ⩌ࡢ୰ࡣ㸪㐠㌿୰࡞ࡽࡧປാ୰ࡢᨾࡶࡋࡃࡣࢽ࣑ࢫ ⤒㦂᭷ࡾ⟅࠼ࡓ⪅ࡀ 㸣Ꮡᅾࡋ࡚࠾ࡾ㸪ࡇࡢ⩌࡛ࡣᨾ࣭ࢽ࣑ࢫ⤒㦂࡞ࡋࡢ⩌ẚ ࡚㸪(66 ᚓⅬࡀ᭷ព㧗ࡗࡓ㸦ᨾ⤒㦂࠶ࡾ⩌s Ⅼᨾ⤒㦂࡞ࡋ⩌s ⅬSᅗ 㸧㸬୍⯡ேཱྀ࡛ࡢ㐣ཤ ᖺ㛫ࡢᒃ╀ࡾ㐠㌿ᨾ⋡ࡀ 㸣௨ୗࡲࡿ ࡢሗ࿌㸦7XUNLQJWRQHWDO㸧ࡽ⪃࠼࡚㸪⾜ືㄏⓎᛶ╧╀㊊ೃ⩌࡛ࡢᨾ⋡ࡣ ࡞ࡾ㧗࠸⪃࠼࡚ࡼ࠸ᛮࢃࢀࡿ㸬 18 16 14 12 ESS score 10 8 6 @ 4 2 0 p< 0.01 Non-accident group(n=67) Accident group(n=19) ᅗ ⾜ືㄏⓎᛶ╧╀㊊ೃ⩌࠾ࡅࡿ ㏻ᨾ᭷↓ࡼࡿ╀ẼᚓⅬࡢẚ㍑ ࡇࢀࡲ࡛㸪Ꮫⓗᡭἲࡼࡾᒃ╀ࡾᨾࡢⓎ⌧≧ἣࡸᨾࡢཎᅉ࡞ࡗࡓ╀ẼࡢⓎ⌧せᅉ ࢆヲ⣽ゎᯒࡋࡓ◊✲ࡣᩘᑡ࡞࠸㸬ࡑࡇ࡛㸪୍⯡ேཱྀ࠾ࡅࡿᒃ╀ࡾ㐠㌿ᨾࡢⓎ⌧せᅉ࠾ ࡼࡧ᭷ຠ࡞╀Ẽᑐฎἲࢆ᫂ࡽࡍࡿࡇࢆ┠ⓗࡋ࡚㸪Ꮫㄪᰝࢆᐇࡋࡓ㸬 21 / 32 ᪉ἲ ㆙どᗇᗓ୰㐠㌿චチヨ㦂ሙ࡛㸪ᨾࡸᒃ╀ࡾ㐠㌿╧╀㛫ࡢ㛵ಀࢆ᫂ࡽࡍࡿࡇ ࢆ┠ⓗࡋࡓࣥࢣ࣮ࢺㄪᰝ⚊㸦㘓 㸧ࢆ㓄ᕸࡋࡓ㸬ᅇᩘࡣ ௳࡛࠶ࡗࡓ㸬ᛶู࣭ ᖺ㱋࣭㌟㛗࣭య㔜ࡀ᫂ࡢࢹ࣮ࢱචチྲྀᚓᚋࡢᮇ㛫ࡀ ᖺᮍ‶࣭᫂ࡢࢹ࣮ࢱࢆ㝖እࡋ㸪 ゎᯒᑐ㇟ࢆᅄ㍯ࡢࡳࢆ㐠㌿ࡍࡿ⪅㸪 ṓ௨ୖ ṓᮍ‶ࡢ⪅㸪୍⯡ࢻࣛࣂ࣮ࢆゎᯒᑐ㇟ ࡋࡓ㸦 ௳㸧 㸦ᅗ 㸧㸬 ㄪᰝෆᐜࡣ㸪ᇶᮏᒓᛶ㸦ᛶู㸪ᖺ㱋㸪㌟㛗㸪య㔜㸪⫋ᴗ㐠㌿ኈ࠺㸪ኪᚑࡢ᭷↓㸧 㸪 㐌᪥ࡢᖹᆒ╧╀㛫㸪╧╀ၥ㢟ࡢ᭷↓㸪㐠㌿㛵ࡍࡿ㡯┠㸦ᖺ㛫㉮⾜㊥㞳࡞㸧㸪㐣ཤ ᖺ㛫 ࠾ࡅࡿᨾࡢ᭷↓࡞ࡽࡧᨾⓎ⏕㛫ᖏ㸪㐣ཤ ᖺ㛫࠾ࡅࡿᒃ╀ࡾ㐠㌿ࡢ᭷↓࡞ࡽࡧ Ⓨ⏕㛫ᖏ㸪ほⓗ╀Ẽ㸦᪥ᮏㄒ∧࢚ࣉ࣮࣡ࢫ╧╀ㄪᰝ⚊㸧㸪㐠㌿୰ࡢ╀Ẽࡢண㜵⟇࡛࠶ࡗ ࡓ㸬 ᅗ ㄪᰝᑐ㇟⪅࣭ゎᯒᑐ㇟⪅ᨾ⤒㦂⪅ࡢேᩘ ఱࡽࡢ㏻ᨾࢆ㉳ࡇࡋࡓ⤒㦂ࡢ᭷↓㸪ᒃ╀ࡾ㐠㌿ࡢ⤒㦂ࡢ᭷↓ࢆᚑᒓኚᩘ㸪♫ேཱྀ ⤫ィᏛୖࡢኚᩘ㸦ᛶู㸪ᖺ㱋㸪%0,㸪චチྲྀᚓᚋࡢᮇ㛫㸪 ࣨ᭶ࡢ㐠㌿㢖ᗘ㸪ᖺ㛫ࡢ㉮⾜㊥㞳㸧㸪 ╧╀㛵㐃ኚᩘ㸦௦ไົᚑ⪅࠺㸪ࣅ࣭࢟╧╀୰ࡢ྾Ṇࢆᣦࡉࢀࡓࡇ ࡀ࠶ࡿ࠺㸪ᖹ᪥ࡢᖹᆒ╧╀㛫㸪㐠㌿୰ࡢ╀Ẽࡢ᭷↓㸧ࢆ⊂❧ኚᩘࡋࡓከኚ㔞ࣟࢪ ࢫࢸࢵࢡᅇᖐศᯒࢆ⾜ࡗࡓ㸬 ⤖ᯝ ゎᯒᑐ㇟⪅ࡢᇶᮏ≉ᛶ㸦ᖺ㱋㸪ᛶู㸧ࡣ⾲ ࡢ࠾ࡾ࡛࠶ࡗࡓ㸬 22 / 32 ⾲ ゎᯒᑐ㇟⪅ࡢᇶᮏ≉ᛶ ㄪᰝࡢ⤖ᯝ㸪㐠㌿୰╀Ẽࢆឤࡌࡓࡇࡢ࠶ࡿࢻࣛࣂ࣮ࡣ 㸣㸪㐣ཤ ᖺᒃ╀ࡾ㐠 ㌿ࢆࡋࡓࡇࡢ࠶ࡿࢻࣛࣂ࣮ࡣ 㸣࡛࠶ࡗࡓ㸬 ᒃ╀ࡾ㐠㌿ᨾ㛵㐃ࡍࡿせᅉࢆ㸪ඹኚ㔞࡛ㄪᩚࡋࡓ࠺࠼࡛㸪ᖹ᪥ࡢ╧╀㛫㸪࠸ࡧࡁ ࡶࡋࡃࡣ↓྾ࢆᣦࡉࢀࡓࡇࡀ࠶ࡿ࠺㸪㐠㌿╀Ẽࡢ㢖ᗘࡢ㛵㐃ࢆࣟࢪࢫࢸ ࢵࢡᅇᖐศᯒࢆ⏝࠸᳨࡚ウࡋࡓࡇࢁ㸪╧╀㛫ࡀ 㛫ᮍ‶ࡢ⪅࡛ࡣ ಸ㸦S㸧㸪 㛫ࡽ㸵㛫ࡢ⪅࡛ࡣ ಸ㸦S 㸧ࡢ࢜ࢵࢬẚࢆ♧ࡋࡓ㸬ࡲࡓ㸪࠸ࡧࡁ↓྾᭷⟅ ࠼ࡓ⪅ࡣ ಸࡢ࢜ࢵࢬẚࢆ♧ࡋࡓࡀ㸪╧╀㛫ࡢ᪉ࡀ㧗࠸࢜ࢵࢬẚࢆ♧ࡋ࡚࠸ࡓ㸦⾲ 㸧㸬 ⾲ ᒃ╀ࡾ㐠㌿ᨾࡢ㛵㐃せᅉ ୖグࢻࣛࣂ࣮ࢆ㸪୍⯡ࢻࣛࣂ࣮㸦 ྡ㸧⫋ᴗ㐠㌿ኈ㸦 ྡ㸧ศ㢮ࡋࡓ㸬⫋ᴗ ࢻࣛࣂ࣮ࡣ୍⯡ࢻࣛࣂ࣮ẚ࡚㸪ࢩࣇࢺ࣮࣡ࢡࡢྜࡀ᭷ព㧗ࡗࡓ㸦㸣YV S㸧㸬ࡲࡓ⫋ᴗ㐠㌿ኈࡣ㸪୍⯡ࢻࣛࣂ࣮ẚ࡚╀Ẽࡼࡿᨾࡸᒃ╀ࡾ㐠㌿ ࡢ㢖ᗘࡀ㧗ࡗࡓ㸦⾲ 㸧㸬 23 / 32 ⾲ ୍⯡ࢻࣛࣂ࣮⫋ᴗ㐠㌿ኈࡢᇶᮏ≉ᛶࡢẚ㍑ 㐠㌿୰╀Ẽࡀ⏕ࡌࡓ㝿㸪ࡢࡼ࠺࡞ᑐฎἲࢆࡗ࡚࠸ࡿࡘ࠸᳨࡚ウࡋࡓࡇࢁ㸪 ᭱ࡶከࡗࡓᑐฎἲࡋ࡚ࡣ㸪 ࠕఇ᠁ࢆࡿ࡛ࠖ㸪୍⯡ࢻࣛࣂ࣮㸪⫋ᴗ㐠㌿ኈࡶ ௨ୖࡢࢻࣛࣂ࣮ࡀ᥇⏝ࡋ࡚࠸ࡓ㸬ࡑࡢࡢᑐฎἲࡋ࡚ࡣ㸪 ࠕ࣒࢞ࢆჶࡴࠖ㸪 ࠕ❆ࢆ㛤ࡅࡿࠖ㸪 ࠕࢥ࣮ࣄ࣮ࢆ㣧ࡴࠖ㸦ࢻࣛࣂ࣮ࡢ 㸧 㸪 ࠕ௬╀ࢆࡿࠖ 㸪 ࠕႚ↮ࠖ 㸦 㸧 㸪 ࠕࣛࢪ࢜ࢆ⫈ࡃࠖ㸪 ࠕྠ⪅ヰࢆࡍࡿࠖ㸦 㸧࡞ࡢᅇ⟅࡛࠶ࡗࡓ㸦ᅗ 㸧 㸬 ᅗ ୍⯡ࢻࣛࣂ࣮㸪⫋ᴗ㐠㌿ኈࡢ㐠㌿୰╀Ẽࡢᑐฎ᪉ἲ ୍⯡ࢻࣛࣂ࣮࡛ࡣ㸪ࢩࣇࢺ࣮࣡ࢡᚑࡋ࡚࠸ࡓࡾ╧╀ࡀ㊊ࡋ࡚࠸ࡿ࡞㸪╀Ẽࡀᙉ ࠸ᛮࢃࢀࡿሙ㠃࡛ࡣ㸪✚ᴟⓗ㐠㌿ࡢ╀Ẽࡢᑐฎἲࢆᐇ㊶ࡋ࡚࠸ࡓ㸬୍᪉㸪⫋ᴗࢻࣛ ࣂ࣮࡛ࡣࡇ࠺ࡋࡓഴྥࡣㄆࡵࡽࢀࡎ㸪㐠㌿╀Ẽࡀ⏕ࡌࡓሙྜ௬╀ࢆࡗ࡚ᑐฎࡍࡿ ࡢࡣ㸪㐣ཤᒃ╀ࡾ㐠㌿ࡼࡾ㏻ᨾࢆ㉳ࡇࡋࡓ⤒㦂ࡢ࠶ࡿ⪅㝈ࡽࢀ࡚࠸ࡓ㸬 24 / 32 ⪃ᐹ ࠸ࡧࡁ↓྾᭷⟅࠼ࡓ⪅ࡣᒃ╀ࡾ㐠㌿ᨾࡢⓎ⏕ࡀ ಸࡢ࢜ࢵࢬẚࢆ♧ࡋ࡚࠸ࡓ㸬ࡓࡔ ࡋᒃ╀ࡾ㐠㌿ᨾࡢ࢜ࢵࢬẚࡣ㸪╧╀㛫ࡢῶᑡࡢ᪉ࡀ㧗ࡗࡓ㸬ࡇࢀࡣ㸪ᒃ╀ࡾ㐠㌿ᨾ ࣜࢫࢡࡋ࡚ࡢ↓྾ࡢㄆ▱ᗘࡀ㧗ࡲࡗࡓ⤖ᯝ㸪↓྾ೃ⩌ᝈ⪅ࡼࡿᨾࡀῶࡗ࡚ࡁࡓ ⤖ᯝ࠸࠼ࡿࡶࡋࢀ࡞࠸㸬୍᪉࡛㸪╧╀㊊ࡼࡿᨾࣜࢫࢡቑຍࢆ㜵ࡄࡓࡵ㸪ࢻࣛ ࣂ࣮ࡢ╧╀㛫ࢆ☜ಖࡍࡿࡓࡵࡢᑐ⟇ࡀᚲせ࡛࠶ࡿ࠸࠼ࡿ㸬㏻ᨾࡸᒃ╀ࡾ㐠㌿ࢆண㜵 ࡍࡿࡓࡵ㸪ࢻࣛࣂ࣮ࡣᑡ࡞ࡃࡶ 㛫௨ୖࡢ╧╀㛫ࢆ☜ಖࡍࡿᚲせࡀ࠶ࡿࡇࡀ♧ ၀ࡉࢀࡓ㸬 ࡇࢀࡲ࡛ᐇ㦂ᐊෆ࡛⾜ࢃࢀࡓከࡃࡢᐇ㦂⤖ᯝࡣ㸪៏ᛶⓗ࡞╧╀㊊ࡀㄆ▱ⓗࣃࣇ࢛࣮࣐ ࣥࢫࢆపୗࡉࡏࡿࡇࢆ♧ࡋ࡚࠸ࡿ㸬ᅗ ࡣ 㛫㸪 㛫㸪 㛫╧╀ࢆ ᪥㛫ࢃࡓ ࡗ࡚⥆ࡅࡓ㝿ࡢ㸪่⃭ᛂㄢ㢟࠾ࡅࡿࣃࣇ࢛࣮࣐ࣥࢫ㸦ぢⴠࡋᩘ㸹㸿㸧ほⓗ╀Ẽ㸦㹀㸧 ࢆ ᪥㛫ࡢ᩿╀ࢆࡋࡓ㝿ࡢ⤖ᯝẚ㍑ࡋࡓᅗ࡛࠶ࡿ㸦9DQ'RQJHQHWDO㸧 㸬 㛫 ࠶ࡿ࠸ࡣ 㛫╧╀ࡀ ᪥㛫⥆ࡃ㸪୍ᬌᚭኪࡋࡓ㝿ྠ➼௨ୖㄢ㢟࠾ࡅࡿぢⴠࡋࡢ ᩘࡣቑຍࡋ࡚࠸ࡿ㸬ࡑࡢ୍᪉࡛㸪ほⓗ╀ẼࡢᚓⅬࡣึࡵࡢᩘ᪥㛫࠾࠸࡚ୖ᪼ࡋࡓᚋࡣ㸪 ࡰ୍ᐃಖࡓࢀ࡚࠸ࡿ㸬ࡇࢀࡽࡢ⤖ᯝࡣ㸪⮬ぬࡋ࡚࠸ࡿ╀Ẽࡢ⛬ᗘ௨ୖ㸪⣼✚ⓗ࡞╧╀ ㊊ࡼࡿㄆ▱ᶵ⬟ࡢపୗࡀ῝้࡛࠶ࡿࡇࢆ♧ࡋ࡚࠸ࡿ㸬 㛫ࡢ㐃⥆ぬ㓰ࡀࣝࢥ࣮ࣝ ⾑୰⃰ᗘ 㸣Ỉ‽┦ᙜ㸦㓇Ẽᖏࡧ㐠㌿ࡢᇶ‽ࡣ 㸣㹼㸧ࡲ࡛ㄆ▱ᶵ⬟ࢆᝏࡉࡏࡿࡇ 㸦'DZVRQHWDO㸧ࢆ⪃࠼ࢀࡤ㸪╧╀㊊ࡀ✚ࡳ㔜࡞ࡗࡓ≧ែ࡛㸪ㄆ▱ᶵ⬟ࡀపୗࡋ ࡚࠸ࡿࡇࢆ⮬ぬࡋ࡞࠸ࡲࡲ㌴ࢆ㐠㌿ࡍࡿࡇࡣ㸪㧗࠸༴㝤ᛶࢆᏎࢇ࡛࠸ࡿ࠸࠼ࡿ㸬 ᅗ ᩿╀࠾ࡼࡧ㒊ศ᩿╀ࢆ⥆ࡅࡓ㝿ࡢ่⃭ᛂㄢ㢟࠾ࡅࡿࣃࣇ࢛࣮ ࣐ࣥࢫ㸦ᕥᅗ㸧ほⓗ╀Ẽ㸦ྑᅗ㸧ࡢኚ㸦9DQ'RQJHQHWDO㸧 ᮏᏛㄪᰝࡢ⤖ᯝࡽࡣ㸪㐠㌿╀Ẽࡘ࠸࡚ࡣ㸪╀Ẽࢆ⤒㦂ࡍࡿ⟅࠼ࡓ⪅ࡣ ಸࢆ㉸ ࠼ࡿ㧗࠸್ࡢ࢜ࢵࢬẚ࡛ᒃ╀ࡾ㐠㌿ᨾ㛵㐃ࡋ࡚࠸ࡓ㸬ࡇࡢࡇࡽ㸪㐠㌿╀Ẽࡢపῶ ἲ࣭㆙࿌ἲࡢὙ⦎ࡀᚲせ࡛࠶ࡿ㸬ࡲࡓ㐠㌿╀Ẽࡀ⏕ࡌࡓሙྜࡣ㸪ఇ᠁ࡋࡓࡾ㸪ࢥ࣮ ࣄ࣮ࢆ㣧ࡴ࡞ࡢᑐฎἲࢆࡿࡇࡼࡗ࡚㸪╀Ẽࡀపῶࡋ㐠㌿ࣃࣇ࢛࣮࣐ࣥࢫࡀୖࡀࡿࡇ ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡋࡋ࡞ࡀࡽ㸪୍⯡ࢻࣛࣂ࣮ẚ࡚⫋ᴗ㐠㌿ኈࡣ㸪ົୖࡢไ⣙ ࡢࡓࡵ㸪㐠㌿ࡢ╀Ẽࡢᑐฎἲࢆ✚ᴟⓗࡽ࡞࠸㸦ࢀ࡞࠸㸧ഴྥࡀ࠶ࡿࡼ࠺࡛࠶ࡿ㸬 ㏻ᨾࢆ㜵Ṇࡍࡿࡓࡵ㸪㐠㌿ኈࡸᴗᑐࡋ࡚ࡢ╧╀ᩍ⫱ࡀᚋ㔜せ࡛࠶ࡿᛮࢃࢀࡿ㸬 25 / 32 ➨ ❶ ࡲࡵᚋࡢᒎᮃ ࠕ╀Ẽࠖࡣ㸪ࣄ࣮࣐࢚࣮࣭ࣗࣥࣛ㏻ᨾࢆᘬࡁ㉳ࡇࡍせ࡞ཎᅉࡢ୍ࡘ࡛࠶ࡿ㸬 ᐇ㦂ᚰ⌮Ꮫⓗ◊✲ࡽࡣ㸪╀Ẽࡢᙉ࠸≧ἣ࡛ࡣసᴗ࢚࣮ࣛࡀቑຍࡍࡿࡔࡅ࡛࡞ࡃ㸪⮬ศࡢ ࢚࣮ࣛẼ࡙ࡃ⬟ຊࡀపୗࡍࡿࡇࢆ♧ࡋࡓ㸬࢚࣮ࣛẼ࡙ࡃ⬟ຊࡀపୗࡍࢀࡤ㸪ᙜ↛࢚ࣛ ࣮㜵Ṇࡢࡓࡵࡢ⾜ືࢆࢀࡎ࢚࣮ࣛࢆᨺ⨨ࡋ࡚㸪ࡁ࡞ᨾࡘ࡞ࡀࡿྍ⬟ᛶࡀ࠶ࡿ㸬 ㏻ᨾࢆ㜵Ṇࡍࡿୖ࡛ࠕ╀Ẽࠖࡣ㔜せ࡞㘽ࢆᥱࡿ㸬ࢻࣛࣂ࣮ࡢ╧╀ࡢ㔞㉁ࡢᨵၿ㸪⏕ά ⎔ቃ࣭ປാ᮲௳ࡢᩚഛ࣭ᕤኵ㸪㐠㌿ࡢ╀Ẽ᳨ฟ࠸ࡗࡓከ᪉㠃ࡽࡢࣉ࣮ࣟࢳ࡛㸪╀Ẽ ࡼࡿ㏻ᨾ㜵Ṇྲྀࡾ⤌ࡴᚲせࡀ࠶ࡿ㸬 Ꮫㄪᰝࡢ⤖ᯝࡽ㸪╧╀㛫ࡀ 㛫ᮍ‶ࡢ⪅࡛ࡣ㸪ᒃ╀ࡾ㐠㌿ࡢࣜࢫࢡࡀ᭷ពୖ᪼ ࡋ࡚࠸ࡓ㸬ᖹᡂ ᖺᅜẸᗣ࣭ᰤ㣴ㄪᰝ࡛ࡣ㸪╧╀㛫 㛫ᮍ‶ࡢ⪅ࡣ⏨ᛶ࡛ 㸪ዪ ᛶ࡛ ࡛࠶ࡗࡓࡇࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬㏻ᨾࢆ㜵Ṇࡍࡿࡓࡵࡣ㸪ኪࡢ╧╀ࢆࡁࡕ ࢇ☜ಖࡍࡿࡇࡀఱࡼࡾ㔜せ࡛࠶ࡿ㸬╧╀ࡢ㔞ࡀ☜ಖࡉࢀ࡚࠸࡚ࡶ㸪╧╀ࡢ㉁ࡀᝏࡋ࡚ ࠸ࡿሙྜࡣ㸪᪥୰ࡢ╀Ẽࡀ⏕ࡌ㸪㏻ᨾࡢࣜࢫࢡࡣቑࡍࡿ㸬⮫ᗋ㐃⥆◊✲ࡢ⤖ᯝ ࡽ㸪╧╀↓྾ೃ⩌ࡢᝈ⪅࡛ࡣ㏻ᨾࣜࢫࢡࡀ㧗࠸ࡇ㸪≉྾㞀ᐖࡀ㔜࡞ሙྜ ࡣ⮬ぬⓗ࡞╀Ẽホ౯ࡀ㕌ࡋ㸪ࡼࡾ㏻ᨾࣜࢫࢡࡀ㧗ࡲࡿࡇࡀ᫂ࡽ࡛࠶ࡗࡓ㸬╧╀ ↓྾ೃ⩌ࢆ⒪ࡍࡿࡇ࡛㸪㏻ᨾࣜࢫࢡࡣᗣ࡞⪅ྠࡌỈ‽࡞ࡿࡇࡽ㸪 ᪩ᮇⓎぢ࣭⒪ࡀᚲせ࡛࠶ࡿ㸬 ⮫ᗋ㐃⥆◊✲࡛ࡣ㸪㐣ཤ ᖺ㛫࠾ࡅࡿ㏻ᨾ⤒㦂ྜࢆ㸪ᖖ⪅ 6$6 ᝈ⪅ࡢ &3$3 ⒪ࡢ๓ᚋ࡛ẚ㍑ࡋࡓ㸬㐣ཤ ᖺ㛫࠾ࡅࡿ㏻ᨾ⤒㦂ྜࡣ㸪୍⯡ᡂேࡀ 㸣࡛࠶ࡿ ࡢᑐࡋ࡚㸪⒪๓ࡢ 6$6 ᝈ⪅࡛ࡣ 㸣㏻ᨾ⤒㦂ྜࡀ ಸ௨ୖ࡛࠶ࡗࡓ㸬ࡋࡋ &3$3 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