Effect of Acupuncture Stimulation on Gastric Mucosal Microcirculation

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ue
t
heg田 t roendos∞ pe and g
e
n
tl
y p l a田 d on t
he
~7Á~'.;!Jr:
g
a
s
t
r
i
c an
t
r
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l mucosa f
o
r me
a
s
ur
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f
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ood f
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I
P1
Blood f
l
o
w va
l
ue
5 f
r
om t
he
l
as
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r
D
o
pp
l
e
rf
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e
c
o
r
d
e
dw
it
ha
c
h
a
r
t re∞ rder (じ228; Ni
p
ponDen5hiKaga ku ,
Japan) and a d
i
g
i
t
a
l p
r
i
n
te
r (ALF P
l
;
ADVANCE) i
n ab5
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l
ut
eu
n
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t5 of ml/min
/1
00g t
i
5
5
u
e(Fi
g
5.2 and 3
)
. Two 5田S lQ ns
of measure
r
n
e
nt were p
er
f
o
rme
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a
c
h
s
u
b
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ct
; on
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a
s
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eme
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a
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i
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o
o
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t
i
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u
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e
r
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e ¥
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e
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l
o
o
d f
lo¥V
d
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r
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ng
acupunc
t
u
r
e
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at
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o
n
s. The t
ot
a
lr
n
ea
sur
ement t
ime
W出 1 0 mi nutes , a
nd a
cupunc
t
ur
estimu
l
at
i
o
n
'"'1R..:Jrあ
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F
i
g
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o
n
t
a
c
to
ff
i
b
e
r
o
p
t
i
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o
b
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t
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Thef
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e
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o
p
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e
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e
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s
e
r
on
s
ta
n
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o
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t
a
c
t
cunatureo
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h
e an trurn , and c
p
r
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s
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u
r
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on
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n
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emaintaine
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E
f
f
e
c
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c
u
p
u
n
c
t
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r
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t
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m
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l
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t
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a
s
l
r
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cMucosal ~ficrocirculation
4
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performed
v
a
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u
e
si
nt
h
e two g
r
o
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p
s
. I
nt
h
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t
i
m
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l
a
t
e
d
h
e va
Ju
e0
1g
a
s
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c mucosa
J b
l
o
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f
low i
n
c
r
e
a
s
e
ds
t
e
a
di
l
y from l
h
es
t
a
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to
f
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n
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t
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s
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e
r
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o
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(
f
rom 2minut田 aft e r t
h
85
t
a
r
to
fm
e
a
s
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r
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ment t
o3r
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n
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t
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e
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n
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m
u
la
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e
d w
ﾎ
t
h
e
x
p
e
r
i
m
e
n
t
)
. The 凹 ints s
stimulation , andshowed ap
e
a
kl
e
v
e
l0
1 21
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:
t7
.
9 ml/min/100 g t
i
s
s
u
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l 8 minutes
(
o
n
er
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i
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f
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r removal o[ a
c
u
p
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n
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t
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c
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p
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r
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e
s(
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.
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nd
i
a
r
n
e
t
e
r
;
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a
p
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n
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e
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t
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h
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r
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u
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n
l
i (ST 36) , and t
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ns
omeo
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h
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u
td
i
d notr
e
tu
r
nL
ot
h
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a
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e
li
ne l
e
ve
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o
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y monitor
e
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l
o
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d pr田 sure s
i
m
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l
t
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n
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o
fb
e
f
o
r
es
t
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m
u
l
a
t
i
o
nu
n
t
i
lt
h
ee
n
do
ft
h
e
o
u
s
l
y wﾎ
t
h measurement of g
a
s
t
r
i
c b
lo
o
d
. I
nt
h
ec
o
n
l
r
o
l group , bl
ood
measurement
f
10w l
e
v
e
l
sd
id n
o
tc
h
a
n
g
el
h
r
o
u
g
h
o
u
tt
h
e
f
l
o
w u
s
i
n
g a b
l
o
o
d pre田 ure momtor
(Finapr田; OhmedaBOCG
roup Inc. , USA)
e
x
p
e
r
i
m
e
n
t
s
. T
h
e
r
ew
e
r
es
i
g
n
i
f
i
c
a
n
t d
i
f
f
e
r
S
t
a
t
i
s
t
i
c
a
l Anal
y
s
i
s
enc田 in t
h
ev
a
l
u
e
so
fb
l
o
o
df
l
o
wb
e
t
w
e
e
n
R田 ult5 we四 expressed a
s mean :
!
:
:SD i
n
c
o
n
t
r
o
l
s and t
h
e s
t
i
m
u
l
a
t
e
d group a
t 3
a
b
s
o
l
u
t
eun
i
t
so
fb
l
oodf
l
o
w (ml/min/100 g
m
i
n
u
t
e
s(
J3.
4:
t3.
lV
5
. 16.6 :t 2.4 , p<O.02) , 日
10w v
o
l
t
i
s
s
u
e
)
. The b
l
o
o
df
umei
ne
a
c
hs
u
b
j
e
c
twasc
a
l
c
u
*
r
o
r
n
1
a
t
e
de
v
e
r
yone rninu担s f
30
2
4 data p
o
i
nt
5 pnn 同 d a
t 2.
5
2
8
n=10
..
ー
s
e
c
ond i
nt
e
r
v
a
l
s
. Di
f
f
er
e
n
c
e
s
26
mean 士 so
b
e
t
w
e
e
n c
o
nt
r
o
l
s and t
h
e
24
s
t
i
r
n
u
l
a
t
e
d group were a
n
a
ｭ
2
2
l
y
z
e
d byS
t
u
d
e
n
t
'
s t一日5t ， and
2
0
c
o
n
s
i
d
e
r
e
d slgni 日 ca nt i
f p
1
8
v
a
l
u
ewasl
e
s
st
h
a
n0
.
0
5
合*
合、.
32ξz-E
E\
)
目
shown i
nF
i
g
.4
B
e
f
o
r
e acupu
nc
tu
re s
t
i
r
n
u
l
a
ｭ
ti on , t
h
e me田 blood f
l
o
w
W出 less t
h
a
n1
5 ml/min/
1
0
0 g t
i
s
su
e w
i
l
h s
i
r
n
i
la
r
mmu 出 are
唱。。-国
Thec
o
n
d
i
t
i
o
n
so
ft
h
es
u
b
j
e
c
ts were s
i
m
i
l
a
r In b
o
th
h
e
yw
e
r
ek
e
p
t
sessions , and t
at 問st d
u
r
i
n
gt
h
es
t
u
d
yp
e
r
i
o
d
. G
a
s
t
r
i
c mucosal b
l
o
o
d
flow was measured f
o
r 1
0
minutes ，出d m
ean f
l
o
wv
o
l
ｭ
ume v
a
l
u
e
s at e
v
e
r
y Qn
e
住。 E
RESULTS
1
6
1
4
1
2
1
0
~
Acupuncture
8
Control
一一・- A
cupuncture
6
.
p
<
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.
0
2
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.
O
l
4
2
。
。
2
4
6
8
1
0
1
2
Time (
m
i
n
.
)
F
i
g
.
4 Mea
nb
loodf
l
o
wv
a
l
u
e
sa
to
n
em
i
n
u
t
ei
n
t
e
r
v
a
l
s
Thev
a
l
u
e
so
fgast口 c m
u
c
o
s
a
lb
l
o
o
df
l
ow i
n
c
r
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s
e
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e
a
dt
l
y
e
nd
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or
e
c
o
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e
rt
ot
h
e
d
u
r
i
n
ga
c
u
p
u
n
c
t
u
r
e stimulation , and t
s
e
r
v
e
d
ba
s
a
ll
e
v
e
lt
h
e
r
e
a
f
t
e
r
. S
i
g
ni
f
ic
a
n
t diffe r enc田 were 0b
b
e
t
w
e
e
nt
h
et
wog
r
o
u
p
sa
13, 6, 7, 8, 9, and1
0m
i
n
u
t
e
s
TheB
u
l
l
et
i
no
fMei
j
i Col
l
e
g
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fOri
e
n
t
a
lM
e
d
i
c
i
n
e No
.1
1:J-9 (
19
9
2
)
5
0
:
t3.
1 VS. 20.1 士 5. 8 ， p<O.OI) , 7
minute
s03.8 :
t2.
8v
s
. 20 .4:t 5.2 , p<O.OI) , 8
mlnut田 (14.0 :
t
1
.8 v
s
. 2 1.7士 7.9 ， p<0.02) , 9
t3
.
3v
s
. 19.8 士 4.8 ， Pく0.0]) ，
minutes 04.
5:
剖d 1
0 mi
n
u
t
e
s 04.2:
t3
.
1 v
s
. 1
9.
1:
t3.5 ,
mmu国(1 4 .1
r-- N . S 一一「
-1
S
5
・・
p<O.OI). F
i
g
u
r
e5s
howst
h
et
o
t
a
lbl
oodflow
Z
(ml/l
OO g t
i
s
s
u
e
) dur
i
n
g 2 minut
e
sb
e
f
o
r
e
320
s
ti
m
u
la
ti
on i
n bot
h groups , s
howing s
i
m
i
l
a
r
凶
n
=1
0
1
0
mean 士 50
valu田 in
t
h
e two g
roups
.The t
o
ta
lb
lood
f
10wvolumeduring5 minutesofa
cupunc
tu
r
e
s
ti
m
u
l
a
t
i
o
na
r
eshown i
nF
i
g
.6
. Tot
a
1blood
f
10w volume duri
ng a
c
u
p
u
n
c
t
u
r
es
t
imula
t
i
on
。
Co
n
l
r
o
l
A
cu
pu
n
c
l
u
r
e
F
i
g
.
5
. T
o
t
a
l b
l
o
o
d f
l
ow volume d
u
r
i
n
g 2
minut
e
s b
e
f
o
r
e s
ti
mulati
o
n i
n b
o
t
h
groups
T
o
t
a
lb
l
o
o
df
l
o
w volume b
e
f
or
es
ti
m
u
l
a
t
i
o
n
showeds
im
i
la
rl
e
v
e
lc
ompare
dwi
t
ht
h
ati
nt
h
e
c
on
tr
o
lgroup
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h
owed as
i
gn
i
f
icantl
yh
ighe
r va
l
uecompared
witht
h
ec
o
n
tr
o
lp
e
ri
o
d(
6
9.
8:
t1
3
.
8i
nc
o
n
t
r
ol
gr
oup VS. 9
0
.7:
t1
6
.
6i
ns
timulat
e
dg roup , p<
0.0 1), and a s
i
m
i
l
a
rd
if
f
e
r
e
n
c
e was a
ls
o ob
10w vol
s
e
r
v
e
di
nt
h
el
e
ve
l
so
ft
o
t
a
lb
l
o
o
df
umed
u
r
i
n
g3 minutes a
f
t
e
rr
emoval of acu
ｭ
punct
u
r
en田dles (
'
1
2
.
8:
t7
.
7i
nc
o
n
t
r
o
l
sv
s
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0
.
7
:
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9i
ns
timul
a
t
e
dgrou p , p
<O
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F
i
g
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1制
1
4
0
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国
n=1
0
2
0
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同
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80
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“ 1曲
富
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1
2
0
n=10
2
0
mean:
t$
D
mean 土 50
。
。
C
on
l
r
o
l
A
cu
p
u
n
c
t
u
re
Con C r川
A
c
u
p
l
l
n
c
tu
r
e
F
i
g
.
6 T
o
t
a
l bl
ood f
l
o
w volume d
u
ri
ng 5
minuteso
fa
cu
p
u
n
c
t
u
r
es
t
i
m
u
l
a
ti
o
n.
F
i
g
.
7
. To 拍 1 b
l
o
o
df
l
ow v
o
lumea
f
t
e
ra
c
u
p
u
n
c
.
t
u
r
es
t
i
m
u
l
a
t
i
o
n
.
T
o
t
a
lb
l
o
o
df
l
o
wvolume d
u
r
i
n
g acupu
n
c
tu
r
e
s
t
i
m
u
l
a
t
i
o
nsho\',red as
i
gn
if
i
c
a
nl
lyhi
g
h
e
rl
e
v
e
l
comparedwi
lhc
ont
r
o
lv
al
ue
s
T
o
t
a
lb
l
o
od 1
f0w ¥'olume a
f
t
e
r removal o
f
a
c
u
p
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n
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t
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e
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howedas
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if
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n
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l
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6
E
f
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e
c
tofAcupunct
u
r
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t
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t
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a
s
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r
i
c v
l
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EBE
Et
--
06
E
B
」司
P
ul
ser
a
t
e{
/
mi
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Acupuncture
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r、-、~、~
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--'"":一、u、---:.../、一一一」福S‘"て軍軍~、=---=、
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00
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o
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十一一ーー
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o
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o
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i
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ig8
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e
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ent
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er
e
c
o
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n
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r
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c
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l
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o
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Thet
r
a
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lo
o
d f1 ow , bl
ood pre 日 ure ， and p
u
l
s
er
a
t
ei
n as
ub
j
ec
td
u
ri
ng
a
c
u
p
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n
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t
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n
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r
e
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s
ei
nb
l
o
o
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l
o
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u
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n
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REFERENCES
1
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c Ac i di り o n G
I
nd
u
c
e
d by Hemorrhage 1
n t
he Rat ,
Ut
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g a Gas
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c Chamb
er T
e
chn
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9
7
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y6
4:1130.........1 135 , 1
: Ac
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Damage I
n
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he Sa lts , Aci d , an
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. 6
8
: 699........101 ,
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)Whitt
l
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chan
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Gast口 c
Muc
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l Damag
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0:45合-460 . 1
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)CheungL Y , Chang:
MucosalBloodF
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e Pal
hogen
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is of a
cut
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Er
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ﾎ
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s.JSurg Res2
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Acut
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c Mu cosa l じ l c er oge n es.Î s
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Gr
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t AS
p
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Er
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For
um 2
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: 351........359 , 1 町 7
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)Wal
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8
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tofAcupunctureStimu
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胃粘膜血流に及ぼす銭刺激の効果
' 1明治誠灸大学第東洋医学臨床教室日明治鋪灸大学内科学教室
要旨
石崎直人*
山村
野引淑衣 日
義治日
瀬山
文世
上村章博日
江川雅人宅
廃
正基'
岡本芳幸'
福井道明日
本郷仁志日
義富辰夫"
下尾和敏日
苗村健治日
矢野
悶粘膜 血流に及ぼす賊刺激の効以について検討した
人男子 10名とした
忠・
山田伸之権
梶山静夫日
対象は回旋患白既往のない 2 0歳代の健常成
胃粘膜血流の測定は検査前日 の午後 9 時以降絶食とした被験者に前処置を行 った後
に胃内視鏡を押入 L. 内視鏡白書1I子孔よりレーザード ッ プラー血涜計のプロープを胃内に姉入 L 断門前
庭部の小湾側粘膜に接触 させて行った
全測定時間は ω分!日l とし
を行い，刺激終了後 3 分間までの粘膜 rfn 流の変動を観察 L.
測定開始 2 分後より 5 分間の鍛刺激
同一被験者における背任刺激時白血流変動と
比較検討した.鎖刺激には羽田20号銭を使用 L. 刺激部位は足三塁穴とした.結集. 鎖刺激開始後より
粘膜血流は徐々に増加し，銭刺激終了後より前値に復する傾向を認めた
3 分.
6 分.
7 分.
8 分.
9 分.
9
この 血流増加は.
i~1定開始後
10分の時点で無中1隙時と比較して有意であった。今回の結果から。足
三里穴への鎖刺激は胃IJ，;忠 に有用 である可能性 が示 唆された