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研究成果報告書PDF（1486KB
平成20年度∼平成24年度私立大学戦略的研究基盤形成支援事業 研究成果報告書
新型インフルエンザ対策に係る
自然科学及び社会科学融合研究
平成25年5月
学校法人名 京都産業大学
大 学 名 京都産業大学
研究組織名 鳥インフルエンザ研究センター
研究代表者 大槻 公一
（京都産業大学・鳥インフルエンザ研究センター・センター長）
ᖹᡂ ᖺᗘ㹼ᖹᡂ ᖺᗘ⚾❧Ꮫᡓ␎ⓗ◊✲ᇶ┙ᙧᡂᨭᴗ
◊
✲
ᡂ
ᯝ
ሗ
࿌
᭩
ࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ಀࡿ⮬↛⛉Ꮫཬࡧ♫⛉Ꮫ⼥ྜ◊✲ࠖ
ᖹᡂ ᖺ ᭶
Ꮫᰯἲேྡ ி㒔⏘ᴗᏛ
Ꮫ ྡ ி㒔⏘ᴗᏛ
◊✲⤌⧊ྡ 㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮
◊✲௦⾲⪅ ᵳ බ୍
㸦ி㒔⏘ᴗᏛ࣭㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮࣭ࢭࣥࢱ࣮㛗㸧
◊✲ᡂᯝሗ࿌᭩ࢆࡲࡵࡿ࠶ࡓࡗ࡚
ி㒔⏘ᴗᏛ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮
ࢭࣥࢱ࣮㛗 ᵳබ୍
㏆࠸ᑗ᮶ฟ⌧ࡍࡿ࡛࠶ࢁ࠺༴ࡉࢀ࡚࠸ࡓࠊ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⏤
᮶ࡍࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㜵ᑐ⟇☜❧ࡢࡓࡵࠊ⮬↛⛉Ꮫ㒊㛛♫⛉Ꮫ㒊㛛
ࡀᐇ㉁ⓗ⼥ྜࡋ࡚ࠊࡼࡾ㧗ᗘ࡞◊✲ᡂᯝࢆ࠶ࡆࡿࡓࡵࡢ◊✲ࣉࣟࢪ࢙ࢡࢺࢆ
❧ࡕୖࡆࡓࠋ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣᐇ㝿ࡣࡇࡽฟ⌧ࡍࡿࡢࠊࡲ
ࡓࠊࡢࡼ࠺࡞ᛶ≧ࢆ᭷ࡍࡿ࢘ࣝࢫࡀฟ⌧ࡍࡿࡢࠊࡢࡼ࠺࡞᪉⟇ࢆ⏝࠸ࢀ
ࡤᅜෆࡢ࢘ࣝࢫࡢධࢆ㜼Ṇ࡛ࡁࡿࡢࠊࡑࢀࡽࡢྍ⬟ᛶࢆ᥎ ࡋ࡚‽ഛࡍ
ࡿᢸᙜࢆᮏᏛᅾ⡠ࡍࡿ⮬↛⛉Ꮫ㒊㛛◊✲⪅ࡀᢸᙜࡋࡓࠋ୍᪉ࠊ᪂ᆺࣥࣇ࢚ࣝ
ࣥࢨࡀⓎ⏕ࡋ࡚ࠊᅜෆ࢘ࣝࢫࡀධࡋࡓሙྜࠊࡢࡼ࠺࡞♫ⓗ࡞ືࡁࢆࡍ
ࢀࡤ࢘ࣝࢫࡢᗈ⠊࡞ศᕸࢆ㜼Ṇ࡛ࡁࡿࡘ࠸࡚ࠊ♫⛉Ꮫ㒊㛛ᅾ⡠ࡍࡿᮏ
Ꮫ◊✲⪅ࡀᢸᙜࡋࡓࠋ୧⪅㛫࠾ࡅࡿሗࢆᐦࡋ࡚ᮏ◊✲ࡢᐇຊࢆὀ
࠸ࡔࠋ
ࡋࡋ࡞ࡀࡽࠊ2009 ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣࠊண␗࡞
ࡾࠊࣈࢱ⏤᮶ࡢ H1N1 ளᆺ࡛ࠊ࣓ࣜ࢝㝣ࡽฟ⌧ࡋࡓࡢ࡛࠶ࡿࠋࡋࡶࠊ
ఏຊࡣᙉࡗࡓࡶࡢࡢࠊࣄࢺᑐࡍࡿཎᛶࡣணࡼࡾࡶᙅࡃࠊ᪂ᆺࣥࣇࣝ
࢚ࣥࢨᑐࡍࡿㄆ㆑ࢆᖜኚ࠼ࡊࡿࢆᚓ࡞ࡗࡓࠋ
୍᪉ࠊᮏ◊✲ࣉࣟࢪ࢙ࢡࢺᐇࡢຠᯝࡣᑡ࡞ࡃ࡞ࡗࡓࠋ⌧ᐇࠊ◊✲௦⾲⪅
࡛࠶ࡿᵳබ୍ᖹᡂ 23 ᖺᗘࡲ࡛♫⛉Ꮫ㒊㛛ࢆᢸᙜࡋ࡚࠸ࡓᕝᮏဴ㑻ᩍᤵࡣࠊ
㗦ពᮏ◊✲ࣉࣟࢪ࢙ࢡࢺࡽᚓࡽࢀࡓ◊✲ᡂᯝࢆྫྷࡋ࡚ウㄽࢆ㔜ࡡࡓ⤖ᯝࠊ⮬
↛⛉Ꮫྛ㡿ᇦ࡛ᚓࡽࢀࡓ◊✲ᡂᯝ♫⛉Ꮫ㒊㛛ࡢ⼥ྜ◊✲ࡣ᫂ࡽ㐍ᒎࡋࡓ
ࡶࡢᛮࢃࢀࡿࠋࡇࢀࡽከࡃࡢ◊✲ᡂᯝࢆࡶࠊ♫⛉Ꮫ◊✲㒊㛛ࡢᕝᮏᩍᤵ
ࡣࠊྠᚿ♫ᏛᏛ㝔㌿⫋ࡋࡓ┤ᚋࡢ 2012 ᖺ 4 ᭶ 12 ᪥㛤ദࡉࢀࡓ➨ 180 ᅇ
ᅜཧ㆟㝔ෆ㛶ጤဨཧ⪃ேࡋ࡚ᣍ⪸ࡉࢀࠊ
ࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇≉ู
ᥐ⨨ἲࠖᡂ❧㔜せ࡞ᙺࢆᯝࡓࡍࡇࡀ࡛ࡁࡓࠋࡑࡢᚋࠊ2012 ᖺ 8 ᭶ 7 ᪥ࠊ
ᨻᗓࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇᭷㆑⪅㆟ᵓᡂဨᑵ௵ࡋࡓࠋ
H1N1 ளᆺ࢘ࣝࢫࡼࡿࣥࣇ࢚ࣝࣥࢨࡣࠊໃࢆࡍࡗࡾᙅࡵࠊᏘ⠇ᛶ
ࣥࣇ࢚ࣝࣥࢨࡢ࢝ࢸࢦ࣮ࣜ⤌ࡳධࢀࡽࢀ࡚࠸ࡿࠋูࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘
ࣝࢫࡢฟ⌧ࡍࡿࡢࡶ㐲ࡃ࡞࠸ணࡉࢀࡿࠋᅇᚓࡽࢀࡓ⭾࡞◊✲ᡂᯝࡀࠊࡑ
ࡢࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㜵㐤ࡁ࡞㈉⊩ࢆࡍࡿࡀᮇᚅ࡛ࡁࡿࠋ
᭱ᚋࠊᮏࣉࣟࢪ࢙ࢡࢺຍࢃࡗ࡚࠸ࡓࡔࡁከ࡞ᑾຊࢆ࠸ࡓࡔ࠸ࡓ㛵ಀྛ
῝⏒࡞ࡿㅰពࢆ⾲ࡋࡲࡍࠋ
1
㹙 ┠ ḟ 㹛
✲◊ ۍᡂᯝሗ࿌᭩ࢆࡲࡵࡿ࠶ࡓࡗ࡚
ۍᵝᘧ 1 ࡢࠕ◊✲ᡂᯝሗ࿌᭩ᴫせࠖ ……………………… 1
ۍ᪂ࡓᚓࡽࢀࡓ◊✲ᡂᯝᴫせ………………………… 41
ۍබ⾲ㄽᩥࠊⴭ᭩ࠊ⥲ㄝࠊゎㄝ➼ ……………………… 64
ۍᡂᯝሗ࿌ ………………………………………………… 84
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ᖹᡂ䠎䠌ᖺᗘ䡚ᖹᡂ䠎䠐ᖺᗘ䛂⚾❧Ꮫᡓ␎ⓗ◊✲ᇶ┙ᙧᡂᨭᴗ䛃㻌
◊✲ᡂᯝሗ࿌᭩ᴫせ㻌
㻌
䠍㻌
㻌
䠏㻌
㻌
䠐㻌
㻌
䠑㻌
㻌
䠒㻌
㻌
䠓㻌
Ꮫᰯἲேྡ㻌 㻌 ி㒔⏘ᴗᏛ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 䠎㻌 Ꮫྡ㻌 㻌 ி㒔⏘ᴗᏛ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
◊✲⤌⧊ྡ㻌 㻌 㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉䞁䝍䞊㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
䝥䝻䝆䜵䜽䝖ᡤᅾᆅ㻌 㻌 ி㒔ᕷ༊ୖ㈡ⱱᮏᒣ㻌 ி㒔⏘ᴗᏛ㻌 㻌 㻌 㻌 㻌 㻌
◊✲䝥䝻䝆䜵䜽䝖ྡ㻌 㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䛻ಀ䜛⮬↛⛉Ꮫཬ䜃♫⛉Ꮫ⼥ྜ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
◊✲ほⅬ㻌 㻌 㻌 ◊✲ᣐⅬ䜢ᙧᡂ䛩䜛◊✲㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
◊✲௦⾲⪅㻌
◊✲௦⾲⪅ྡ㻌
ᡤᒓ㒊ᒁྡ㻌
⫋ྡ㻌
ᵳ㻌 බ୍㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉䞁䝍䞊㻌
䝉䞁䝍䞊㛗㻌
㻌
䠔㻌 䝥䝻䝆䜵䜽䝖ཧຍ◊✲⪅ᩘ㻌 㻌 㻌 䠍䠐㻌 㻌 ྡ㻌
㻌
䠕㻌 ヱᙜᑂᰝ༊ศ㻌 㻌 㻌 㻌 ⌮ᕤ䞉ሗ㻌 㻌 㻌 㻌 㻌 ⏕≀䞉་ṑ㻌 㻌 㻌 㻌 㻌 ேᩥ䞉♫㻌 㻌
㻌
䠍䠌㻌 ◊✲䝥䝻䝆䜵䜽䝖䛻ཧຍ䛩䜛䛺◊✲⪅㻌
◊✲⪅ྡ㻌
ᵳ㻌 බ୍㻌
㧘᱓㻌 ᘯᶞ㻌
⸭⏣㻌 ῄண㻌
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⛅⏣㻌 ⸅㻌
ᮌ㻌 ⫕㻌
᳃㻌 ຬః㻌
ᡤᒓ䞉⫋ྡ㻌
㫽䜲䞁䝣䝹䜶䞁
䝄◊✲䝉䞁䝍
䞊䞉䝉䞁䝍䞊㛗㻌
⥲ྜ⏕⛉Ꮫ
㒊䞉ᩍᤵ㻌
㫽䜲䞁䝣䝹䜶䞁
䝄◊✲䝉䞁䝍
䞊䞉≉ᐃ◊✲ဨ
䠄㼀㻾䠅㻌
⥲ྜ⏕⛉Ꮫ
㒊䞉ᩍᤵ㻌
⥲ྜ⏕⛉Ꮫ
㒊䞉ຓᩍ㻌
⥲ྜ⏕⛉Ꮫ
㒊䞉≉ᐃ◊✲ဨ
䠄㻾㻭䠅㻌
⥲ྜ⏕⛉Ꮫ
㒊䞉≉ᐃ◊✲ဨ
䠄㻾㻭䠅㻌
䝥䝻䝆䜵䜽䝖䛷䛾◊✲ㄢ㢟㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
㔝㫽ཬ䜃㣫⫱㭜䛾⾑ΎᏛ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ᾐ
₶≧ἣ䛾ᢕᥱ㻌
ື≀䛛䜙䛾䜴䜲䝹䝇ศ㞳䛸ᛶ≧ゎ
ᯒ㻌
䜴䜲䝹䝇䛾ኚ␗䛾≧ἣ䜢ᢕ
ᥱ㻌
ື≀䛛䜙䛾䜴䜲䝹䝇ศ㞳䛸ᛶ≧ゎ
ᯒ㻌
䜴䜲䝹䝇䛾ኚ␗䛾≧ἣ䜢ᢕ
ᥱ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷᐜయ
䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷᐜయ
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Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
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Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
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Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
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−1−
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䝆ᶵ⬟䛻ཬ䜌䛩ᙳ㡪䛸ኳ↛
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㒊䞉ᩍᤵ
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ᵓ㐀ゎᯒ㻌
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≀රჾᑐ⟇䛸䛧䛶䛾ἲつไ㻌
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䠄ඹྠ◊✲ᶵ㛵➼䠅㻌
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S0801062
᪂ᆺ䜲䞁䝣䝹䜶䞁䝄Ⓨ⏕䛾
ᣑᩓ䝟䝍䞊䞁ᩘ⌮ⓗゎᯒ㻌
᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻ᑐ䛩䜛
ᅜ㐃䞉㼃㻴㻻 ➼䛻䜘䜛ἲᨻ⟇
䛾ືྥཬ䜃䝞䜲䜸䝔䝻䝸䝈䝮
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䠘◊✲⪅䛾ኚ᭦≧ἣ䠄◊✲௦⾲⪅䜢ྵ䜐䠅䠚㻌
ᪧ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
ឤᰁື≀䛾⌮Ꮫⓗ᳨⣴㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉
୰㻌 㞞ᬗ㻌
䞁䝍䞊䞉௵◊✲ဨ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
ᚑ᮶䛾䜲䞁䝣䝹䜶䞁䝄䜴䜱䝹
䝇䛸䛾ཎᛶẚ㍑㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠌ᖺ㻌 䠓᭶㻌 䠍䠎᪥䠅㻌
㻌
㻌
᪂㻌
ኚ᭦๓䛾ᡤᒓ䞉⫋ྡ㻌
ኚ᭦䠄ᑵ௵䠅ᚋ䛾ᡤᒓ䞉⫋ྡ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉䞁䝍
๐㝖䠄≀ᨾ䛾䛯䜑䠅㻌
䞊䞉௵◊✲ဨ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
୰㻌 㞞ᬗ㻌
㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
⥲ྜ⏕⛉Ꮫ㒊䞉≉ᐃ◊
ᮌ㻌 ⫕㻌
✲ဨ䠄㻾㻭䠅㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠍ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
⥲ྜ⏕⛉Ꮫ㒊䞉≉ᐃ◊
▼⏣㻌 ᭷ᕼᏊ㻌
✲ဨ䠄㻾㻭䠅㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠍ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
㻌
−2−
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
◊✲⪅Ặྡ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉
ୖ㻌 ⍞Ụ㻌
䞁䝍䞊䞉௵◊✲ဨ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠎ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
ື≀䛛䜙䛾䜴䜲䝹䝇ศ㞳䛸
ᛶ≧ゎᯒ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉
⸭⏣㻌 ῄண㻌
䞁䝍䞊䞉≉ᐃ◊✲ဨ䠄㼀㻾䠅
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
䜴䜱䝹䝇䛾ኚ␗䛾≧ἣ䜢ᢕ
ᥱ㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠎ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
ᪧ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
◊✲⪅Ặྡ㻌
⥲ྜ⏕⛉Ꮫ㒊䞉≉ᐃ◊
▼⏣㻌 ᭷ᕼᏊ㻌
✲ဨ䠄㻾㻭䠅㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠏ᖺ㻌 䠏᭶㻌 䠏䠍᪥䠅㻌
㻌
㻌
᪂㻌
ኚ᭦๓䛾ᡤᒓ䞉⫋ྡ㻌
ኚ᭦䠄ᑵ௵䠅ᚋ䛾ᡤᒓ䞉⫋ྡ㻌
⥲ྜ⏕⛉Ꮫ㒊䞉≉ᐃ◊✲ဨ ๐㝖䠄≉ᐃ◊✲ဨ㻔㻾㻭㻕㏥⫋䛾䛯
䠄㻾㻭䠅㻌
䜑䠅㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
▼⏣㻌 ᭷ᕼᏊ㻌
㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
䜲䞁䝣䝹䜶䞁䝄 㻭 䜴䜲䝹䝇㻌
㻾㻺㻭 䝫䝸䝯䝷䞊䝊䛾 㼄 ⥺⤖ ⥲ྜ⏕⛉Ꮫ㒊䞉ᩍᤵ㻌
ᬗᵓ㐀ゎᯒ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
ὠୗ㻌 ⱥ᫂㻌
䜲䞁䝣䝹䜶䞁䝄 㻭 䜴䜲䝹䝇
㻾㻺㻭 䝫䝸䝯䝷䞊䝊䛾 㼄 ⥺⤖ᬗ
ᵓ㐀ゎᯒ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
㭯ᮧ㻌 ಇ㻌
䜲䞁䝣䝹䜶䞁䝄 㻭 䜴䜲䝹䝇
㻾㻺㻭 䝫䝸䝯䝷䞊䝊䛾 㼄 ⥺⤖ᬗ
ᵓ㐀ゎᯒ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠏ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
䜲䞁䝣䝹䜶䞁䝄 㻭 䜴䜲䝹䝇㻌
㻾㻺㻭 䝫䝸䝯䝷䞊䝊䛾 㼄 ⥺⤖ ⥲ྜ⏕⛉Ꮫ㒊䞉ຓᩍ㻌
ᬗᵓ㐀ゎᯒ㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠏ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
ᪧ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
ື≀䛛䜙䛾䜴䜲䝹䝇ศ㞳䛸
ᛶ≧ゎᯒ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉
ᖖᅧ㻌 Ⰻኴ㻌
䞁䝍䞊䞉◊✲ဨ㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠐ᖺ㻌 䠏᭶㻌 䠏䠍᪥䠅㻌
㻌
㻌
㻌
−3−
䜴䜲䝹䝇䛾ኚ␗䛾≧ἣ䜢ᢕ
ᥱ㻌
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
᪂㻌
ኚ᭦๓䛾ᡤᒓ䞉⫋ྡ㻌
ኚ᭦䠄ᑵ௵䠅ᚋ䛾ᡤᒓ䞉⫋ྡ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉䞁䝍
๐㝖䠄㏥⫋䛾䛯䜑䠅㻌
䞊䞉◊✲ဨ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
ᖖᅧ㻌 Ⰻኴ㻌
㻌
㻌
ᪧ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉
ୖ㻌 ⍞Ụ㻌
䞁䝍䞊䞉௵◊✲ဨ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠐ᖺ㻌 䠏᭶㻌 䠏䠍᪥䠅㻌
㻌
㻌
᪂㻌
ኚ᭦๓䛾ᡤᒓ䞉⫋ྡ㻌
ኚ᭦䠄ᑵ௵䠅ᚋ䛾ᡤᒓ䞉⫋ྡ㻌
㫽䜲䞁䝣䝹䜶䞁䝄◊✲䝉䞁䝍
๐㝖䠄㏥⫋䛾䛯䜑䠅㻌
䞊䞉௵◊✲ဨ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
ୖ㻌 ⍞Ụ㻌
㻌
㻌
ᪧ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛸ேᶒ㻌
ἲົ◊✲⛉䞉ᩍᤵ㻌
ᕝᮏ㻌 ဴ㑻㻌
᪂ᆺ䜲䞁䝣䝹䜶䞁䝄Ⓨ⏕䛾
ேᶒಖㆤ㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠐ᖺ㻌 䠏᭶㻌 䠏䠍᪥䠅㻌
㻌
㻌
᪂㻌
ኚ᭦๓䛾ᡤᒓ䞉⫋ྡ㻌
ኚ᭦䠄ᑵ௵䠅ᚋ䛾ᡤᒓ䞉⫋ྡ㻌
◊✲⪅Ặྡ㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
ἲົ◊✲⛉䞉ᩍᤵ㻌
๐㝖䠄㏥⫋䛾䛯䜑䠅㻌
ᕝᮏ㻌 ဴ㑻㻌
㻌
㻌
㏣ຍ㻌
䢈䢛䢗䡸䢚䡦䡴䢀䛷䛾◊✲ㄢ㢟㻌
ᡤᒓ䞉⫋ྡ㻌
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ཷ
ᐜయ䛾ゎᯒ䛸ឤᰁᶵᵓ䛾ゎ
᫂㻌
◊✲⪅Ặྡ㻌
⥲ྜ⏕⛉Ꮫ㒊䞉≉ᐃ◊
᳃㻌 ຬః㻌
✲ဨ䠄㻾㻭䠅㻌
䝥䝻䝆䜵䜽䝖䛷䛾ᙺ㻌
Ẽ㐨ୖ⓶䛺䛹䛾䝮䝏䞁ୖ䛾
ཷᐜయ䛸ឤᰁᶵᵓ䛾ゎ᫂㻌
䠄ኚ᭦䛾ᮇ䠖ᖹᡂ䠎䠐ᖺ㻌 䠐᭶㻌 䠍᪥䠅㻌
㻌
䠍䠍㻌 ◊✲䛾ᴫせ䠄䈜㻌 㡯┠య䜢䠍䠌ᯛ௨ෆ䛷సᡂ䠅㻌
䠄䠍䠅◊✲䝥䝻䝆䜵䜽䝖䛾┠ⓗ䞉ព⩏ཬ䜃ィ⏬䛾ᴫせ㻌
◊✲┠ⓗ࣭ព⩏
㏆ᖺࠊ㫽ࣥࣇ࢚ࣝࣥࢨࡼࡿ⿕ᐖࡣ༢㫽㢮Ṇࡲࡽࡎࠊே⋇ඹ㏻ឤᰁࡋ࡚ே㢮ከ
࡞⬣ጾ࡞ࡗ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺࡣࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢᐟᇦࡢỴᐃཬࡧឤᰁᶵ
ᵓ࠶ࡿ࠸ࡣឤᰁ⤒㊰ࡢ✲᫂ࢆࡣࡾࠊಶேࡽᅜᐙࣞ࣋ࣝ⮳ࡿࣥࣇ࢚ࣝࣥࢨὶ⾜ᑐࡍࡿ
༴ᶵ⟶⌮ࡢ☜❧ࡘ࠸࡚ࠊ⥲ྜⓗ◊✲ࢆ᥎㐍ࡍࡿᣐⅬࡢᙧᡂࢆ┠ᣦࡍࠋࡍ࡞ࢃࡕࠊ᪂ᆺࣥࣇ
࢚ࣝࣥࢨࡢฟ⌧ࡋࡓሙྜࠊཎᅉ࢘ࣝࢫࡢឤᰁ㜵Ṇࢆࡣࡿ⮬↛⛉Ꮫⓗ࡞ᇶ♏◊✲♫ᨻ⟇
ࡢࣞ࣋ࣝࡽᘏࢆ㜵Ṇࡍࡿ⥲ྜ⛉Ꮫⓗ࡞ᛶ㉁ࢆᣢࡘࠊ♫ⓗព⩏ࡢ㧗࠸◊✲࡛࠶ࡿࠋ
◊✲ィ⏬ࡢᴫせ
ᅜෆእ࠾ࡅࡿ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⏕ែேࢆྵࡴங㢮ࡢぶᛶࡘ࠸࡚┘ど
−4−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ࢆ⾜࠺ࠋᚓࡽࢀࡓᡂᯝࢆᇶࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢᘏ㛵ࡍࡿᩘ⌮ⓗゎᯒࢆ⾜࠸ࠊ♫ⓗ
༴ᶵ⟶⌮ࡸேᶒ㛵ࡍࡿἲᨻ⟇ࢆ☜❧ࡍࡿࠋᐟഃࡢཷᐜయࢆ୰ᚰㄪࠊཷᐜయᣕᢠ≀㉁ࡢ
㛤Ⓨࡸ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫⓎ⌧ࡢྍ⬟ᛶࡘ࠸࡚ࡢゎᯒࢆ⾜࠺ࠋᢠ࢘ࣝࢫάᛶࢆ᭷
ࡍ⣲ᮦࡢ㛤Ⓨཬࡧホ౯ࢆ⾜࠺ࠋ
ᖹᡂ ࠊ ᖺᗘࡣ :+2 ࡢ⌮ᛕࠊάືࠊ༴ᶵ⟶⌮ᨻ⟇ཬࡧㅖᅜᐙࡢᑐᛂ࡞ࡢศᯒࡽ◊✲ࢆ
ጞࡵࠊす᪥ᮏ࡛ࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫศ㞳ศᏊ㑇ఏᏛⓗゎᯒࠊ㫽Ẽ㐨ୖ⓶⤌⧊ཷᐜయ
ศᏊࡢྠᐃࠊᢠ࢘ࣝࢫᛶ⣲ᮦࡢ᳨⣴ࢆᐇࡍࡿࠋᖹᡂ ࠊ ᖺᗘࡣᅜෆእศ㞳࢘ࣝࢫࡢᛶ
≧ẚ㍑ࠊ⏕≀රჾᑐ⟇ࡢᐇែㄪᰝ༴ᶵ⟶⌮ᨻ⟇ࡢ❧ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢఏࠊ
ᣑᩓࡢᩘ⌮ࣔࢹࣝࡢጇᙜᛶࢆ᳨ウࡍࡿࠋᖹᡂ ᖺᗘࡣ᪂ᆺࣥࣇ࢚ࣝࣥࢨⓎ⏕ཬࡰࡍ㫽ࣥ
ࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢᙳ㡪ࡢホ౯ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ༴ᶵ⟶⌮ᨻ⟇ࡢ☜❧ࠊ᪂ᆺࣥࣇ࢚ࣝ
ࣥࢨ࢘ࣝࢫఏ㐣⛬✲᫂ࠊศἪᆺ࣒ࢳࣥࡼࡿ࢘ࣝࢫࡢ㝖⭷ᆺ࣒ࢳࣥࡢ࢘ࣝࢫࡢ
⤖ྜࡢ㛵㐃ゎᯒࢆᐇࡍࡿࠋ㻌
䠄䠎䠅◊✲⤌⧊㻌
㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮㛗ࡢᵳ㸦⥲ᣓ㸧ࢆ୰ᚰࡋ࡚ᮏ◊✲ࣉࣟࢪ࢙ࢡࢺࡢ◊✲యไࡣ
⤌ࡲࢀ࡚࠸ࡿࠋே␗ືࡀ◊✲ᐇ୰࠶ࡾࠊ᭱⤊ⓗࡣྜィ ྡࡀཧ⏬ࡋࡓࠋෆヂࡣࠊᩍဨࡀ
ྡࠊ㹐㸿ࡀ ྡ࡛࠶ࡿࠋ㏵୰࡛◊✲ဨࡀ ྡࠊ㹐㸿ࡀ ྡ㏥⫋ࡋࡓࠋ ྛ◊✲⪅ࡢᙺศᢸࡋ࡚ࠊඛࡎࠊᅜෆእ࠾ࡅࡿ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆ୰ᚰࡋࡓ᪂ᆺ
ࢆྵࡴྛ✀ື≀ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⏕ែࠊேࡢఏຊཬࡧᚋࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢὶ
⾜ண ࢆ࢘ࣝࢫᛶ≧ࡢゎᯒࢆ㧘᱓ࠊᖖᅧࠊ⸭⏣ࡀᐇࡋࡓࠋࡲࡓࠊ⣽㔝ࡀ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢ
ᛶ≧ゎᯒࡽண ࡉࢀࡿᮏᘏ㛵ࡍࡿᩘ⌮ⓗゎᯒࢆᐇࡋࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨⓎ⏕ཬࡧὶ
⾜࠾ࡅࡿ♫ⓗ༴ᶵ⟶⌮ࡸேᶒಖㆤ㛵ࡍࡿἲᨻ⟇ࡢ☜❧ᕝᮏཬࡧᒾᮏࡀཧ⏬ࡋࡓࠋ
㧘᱓ࠊᖖᅧࠊୖࠊ⸭⏣ࠊ℩ᑿࡀࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨὶ⾜ࢆ㜼Ṇࡍࡿ㔜せ࡞ᡭẁࡋ࡚ࡢᡭẁ
ࡋ࡚ࡢࠊᢠ࢘ࣝࢫάᛶࢆ᭷ࡍ⣲ᮦࡢ㛤Ⓨཬࡧࡑࡢ⣲ᮦࡢᢠ࢘ࣝࢫຠᯝࡢ᳨ドࢆ⾜ࡗࡓࠋຍ࠼
࡚ࠊ୰⏣ࠊ⛅⏣ࠊୖࠊᮌࠊ▼⏣ࠊ➉ෆࠊ⚟ࠊὠୗࠊ㭯ᮧࡣࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
ࡘ࠸࡚ࠊ࢘ࣝࢫഃࡽࡢࡳ࡞ࡽࡎᐟഃࡢཷᐜయ࠶ࡿ࠸ࡣච≉ᛶࢆ୰ᚰㄪࡿࡼࡾࠊᖹ
ᡂ ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཎᏛⓗព⩏ࡢゎᯒࡶᐇࡋࡓࠋ
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆಖ⟶ࡋ࡚࠸ࡿ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮ࢆ୰ᚰࠊྛ◊✲ࢳ࣮࣒
㛫ࡢሗࢆᖖ⾜࡞ࡗࡓࠋタഛࡶྍ⬟࡞㝈ࡾྛ◊✲ࢳ࣮࣒࡛⏝࡛ࡁࡿࡼ࠺ࡾࡣࡗࡓࠋ
ඹྠ◊✲ᶵ㛵ࡣ࡞࠸ࡀࠊᏛ⾡ὶ༠ᐃࡢ⤖ࡤࢀ࡚࠸ࡿ㫽ྲྀᏛ㎰Ꮫ㒊㝃ᒓ㫽⏤᮶ே⋇ඹ㏻Ꮫ◊✲
ࢭࣥࢱ࣮ࡣࠊᐦሗࢆ⾜࡞࠸ࠊᚲせᛂࡌඹྠ◊✲ࢆ⾜࡞ࡗࡓࠋ
䠄䠏䠅◊✲タ䞉タഛ➼㻌
࠙◊✲タࠚ
㸺+㹼 ᖺ㸼➨ ᐇ㦂ᐊᲷ ᐇ㦂ᐊ ੍ ྡ
➨ ᐇ㦂ᐊᲷ➨ ᐇ㦂◊✲ᐊ ੍ ྡ
➨ ᐇ㦂ᐊᲷ➨ ᐇ㦂◊✲ᐊ ੍ ྡ
➨ ᐇ㦂ᐊᲷࢡ࣮࣮࣒ࣜࣥࣝ ੍ ྡ
➨ ᐇ㦂ᐊᲷࢡ࣮࣮࣒ࣜࣥࣝ ੍ ྡ
➨ ᐇ㦂ᐊᲷ➨ ᐇ㦂◊✲ᐊ ੍ ྡ
➨ ᐇ㦂ᐊᲷศᏊ⣽⬊ᕤᏛᐇ㦂◊✲ᐊ ੍ ྡ
㸺+㹼 ᖺ㸼➨ ᐇ㦂ᐊᲷ ◊✲ᐊ ੍ ྡ
➨ ᐇ㦂ᐊᲷ ᐇ㦂‽ഛᐊ ੍ ྡ
㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮㸦ሗᢏ⾡ᐇ㦂ᐊᲷ㸧 ੍ ྡ
㸺+㹼 ᖺ㸼➨ ◊✲ᐊᲷ ◊✲ᐊ ੍ ྡ
㸺+㹼 ᖺ㸼 ྕ㤋 ◊✲ᐊ ੍ ྡ
㸺+㹼 ᖺ㸼 ྕ㤋 ᐇ㦂ᐊ ੍ ྡ
ྕ㤋 % ᐇ㦂ᐊ ੍ ྡ
ྕ㤋 ࢡ࣮࣮࣒ࣜࣥࣝ ੍ ྡ
ྕ㤋 ᇵ㣴ᐊ ੍ ྡ
ྕ㤋 ᐇ㦂ᐊ ੍ ྡ
ྕ㤋 ᩍဨᐇ㦂ᐊ ੍ ྡ
−5−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ྕ㤋 ◊✲ᐊ ੍ ྡ
ྕ㤋㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮ ੍ ྡ
㸺+㹼 ᖺ㸼 ྕ㤋 ◊✲ᐊ ੍ ྡ
ྕ㤋➨ ᐇ㦂ᐊ ੍ ྡ
ྕ㤋◊✲ᐊ ' ੍ ྡ
ྕ㤋 ᐇ㦂◊✲ᐊ ੍ ྡ
࠙タഛࠚ
ᮏ◊✲ࣉࣟࢪ࢙ࢡࢺ◊✲ࢆᐇࡍࡿࡓࡵ௨ୗࡢഛရࢆ㉎ධࡋ࡚ά⏝୰࡛࠶ࡿࠋ
㸺ᖹᡂ ᖺᗘ㸼
࣭ඹ↔Ⅼ㢧ᚤ㙾 63( ୍ᘧ࣭࣭࣭࢘ࣝࢫឤᰁᶵᵓࡢゎᯒࡢࡓࡵ⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫 㛫㸧
㸺ᖹᡂ ᖺᗘ㸼
࣭㐲ᚰ⨨୍ᘧ࣭࣭࣭࣒ࢳࣥࡢ༢㞳⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫 㛫㸧
௨ୖ ഛရࡣ࠸ࡎࢀࡶ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮㸦ᪧࢭࣥࢱ࣮ ੍࣭᪂ࢭࣥࢱ࣮
੍㸧タ⨨ࠋ
㸺ᖹᡂ ᖺᗘ㸼
࣭㧗㏿ᐜ㔞෭༷㐲ᚰᶵ୍ᘧ࣭࣭࣭࢘ࣝࢫ⢏Ꮚࠊࢱࣥࣃࢡ㉁ࡢ⢭〇⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫
㛫㸧
࣭࣮࢜ࢺࢡ࣮ࣞࣈ ྎ࣭࣭࣭࢘ࣝࢫᛶ≧ゎᯒᚋࡢヨᩱࡢ⁛⳦⏝ࡋ࡚࠸ࡿࠋ
㸦✌ാ㛫
㛫㸧
࣭ಖ෭ᗜ㸦⣙ /㸧࣭࣭࣭ྛ✀ヨᩱࡢಖᏑࡢࡓࡵ⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫 㛫㸧
࣭㑇ఏᏊᑟධ⨨㸦✌ാ㛫 㛫㸧
࣭㟁ẼὋືࢱࣥࣃࢡ㉁㌿⨨㸦✌ാ㛫 㛫㸧
࣭࣮࣡ࢡࢫࢸ࣮ࢩ୍ࣙࣥᘧ㸦✌ാ㛫 㛫㸧
㸺ᖹᡂ ᖺᗘ㸼
࣭㺱㺡㺼㺷 㺪㺽㺸㺍㺪㺽㺜㺷࣭࣭࣭࢘ࣝࢫࢱࣥࣃࢡ㉁ࡢศ㞳⢭〇⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫 㛫㸧
࣭ࢩࣥࢢࣝࢳ࣮ࣗࣈ࣑ࣝࣀ࣓࣮ࢱ࣮࣭࣭࣭࢘ࣝࢫάᛶࡢ ᐃ⏝ࡋ࡚࠸ࡿࠋ
㸦✌ാ㛫 㛫㸧
࣭⸆⏝ಖ෭ᗜ࣭࣭࣭ྛ✀ヨᩱࡢಖᏑࡢࡓࡵ⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫 㛫㸧
࣭࣮ࣥ࢟ࣗ࣋ࢱ࣮㸦෭ᶵ㸧࣭࣭࣭ྛ✀ヨᩱࡢಖᏑࡢࡓࡵ⏝ࡋ࡚࠸ࡿࠋ㸦✌ാ㛫
㛫㸧
࣭ᚤ㔞㧗㏿෭༷㐲ᚰᶵ࣭࣭࣭࢘ࣝࢫࡽࡢ 51$ ᢳฟ⏝ࡋ࡚࠸ࡿࠋ
㸦✌ാ㛫 㛫㸧 㸺ᖹᡂ ᖺᗘ㸼
࣭㉸㧗⢭⣽࣮࢝ࣛ෭༷࣓࢝ࣛ࣊ࢵࢻ୍ᘧ㸦✌ാ㛫 㛫㸧㻌
䠄䠐䠅◊✲ᡂᯝ䛾ᴫせ㻌 䈜ୗグ䚸䠍䠏ཬ䜃䠍䠐䛻ᑐᛂ䛩䜛ᡂᯝ䛻䛿ୗ⥺ཬ䜃䠆䜢䛩䛣䛸䚹
◊✲䝥䝻䝆䜵䜽䝖䛾ィ⏬䜔┠ⓗ䞉ព⩏䛸㛵㐃䛵䛡䛶䚸ᙜึ䛾┠ᶆ䜢䛹䜜䛰䛡㐩ᡂ䛧䛯䛛グ㏙䛩䜛䛸䛸䜒䛻䚸᪂䛯
䛻ᚓ䜙䜜䛯▱ぢ䛺䛹䛻䛴䛔䛶䜒ලయⓗ䛻グ㏙䛧䛶䛟䛰䛥䛔䚹㻌
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㛵ࡍࡿ◊✲ࢆ㛗ᖺ⥆ࡅ࡚ࡁࡓᮏ◊✲ࣉࣟࢪ࢙ࢡࢺࡢᵳࠊ㧘᱓ࡣࠊ
ḟࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫฟ⌧㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣ῝ࡃ㛵ࡍࡿྍ⬟ᛶࢆ⪃࠼ࠊ
ࡋࡶ᭱ึฟ⌧ࡍࡿࡢࡣ +1 㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀ⃰ᐦศᕸࡍࡿࢪᆅᇦࠊ≉୰ᅜ
ࡶࡋࡃࡣᮾ༡ࢪࡢྍ⬟ᛶࡀ᭱ࡶ㧗࠸ࡢ࡛ࡣ࡞࠸ணࡋ࡚࠸ࡓࠋࡑࡇ࡛ࠊ࣋ࢺࢼ࣒㒊ࢆ୰
ᚰࠊ⏕ᜥࡍࡿྛ✀㔝㫽ࠊ㭜ࡸࣄࣝ➼ࡢᐙࡁࢇ㢮ࢱ࣮ࢤࢵࢺࢆ⤠ࡾㄪᰝࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ
+1 ࢘ࣝࢫࡣୖグ㫽㢮ࡽ⛥ศ㞳ࡉࢀࡓࡢࡳ࡛࠶ࡗࡓࡀࠊேࡢឤᰁຊࡶᙅࡃ࡞࠸ูࡢளᆺࠊ
ࡍ࡞ࢃࡕࠊ+1ࠊ+1 ࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆࠊ㭜ࡸࣄࣝࡽࡤࡾ࡛࡞ࡃࠊᵝࠎ࡞㔝㫽
ࡽ࡞ࡾ㢖⦾ศ㞳࡛ࡁ࡚࠸ࡿࠋࡍ࡞ࢃࡕࠊ࣋ࢺࢼ࣒ࡢࡼ࠺࡞ᮾ༡ࢪㅖᅜ࡛ࡣࠊ᪥ᮏᅜෆࡢ
≧ἣ␗࡞ࡾࠊ㣫⫱ࡉࢀ࡚࠸ࡿ㭜⩌ࡸࣄࣝ࠾࠸࡚ࠊእぢୖᗣ࡛࠶ࡗ࡚ࡶࠊྛ✀㫽ࣥࣇ࢚ࣝ
ࣥࢨ࢘ࣝࢫࢆᖖಖ᭷ࡋ࡚࠸ࡿࡇࠊࡉࡽࡣእぢୖᗣ࡞ࣄࣝ➼ࡢỈࡁࢇ㢮ࡶࡋ࡚ᙉẘ
ࡢ +1 㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁࡋ࡚࠸ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡇࢀࡽࡢᅜࠎ࡛ࡣࠊேࡶ
+1 ளᆺࡢࡳ࡞ࡽࡎᵝࠎ࡞ளᆺࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㢧ᛶឤᰁࡋ࡚࠸ࡿྍ⬟ᛶࡶྰᐃ
࡛ࡁ࡞࠸ࡇࡀศࡗ࡚ࡁࡓࠋࡋࡓࡀࡗ࡚ࠊ㏆࠸ᑗ᮶ࠊᮾ༡ࢪࡽ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
⏤᮶ࡍࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢฟ⌧ࡍࡿࡇࡣ༑ศ⪃៖ࡍࡿᚲせࡢ࠶ࡿࡇࡀ᫂ࡽ࡞ࡗ
ࡓࠋࡇࢀࡽࡢ◊✲ᡂᯝཬࡧᐇ㝿 ᖺ⡿㝣ࡽୡ⏺ᣑᩓࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㛵ࡍ
−6−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ࡿᏛⓗሗཬࡧཎᅉ࢘ࣝࢫࡢᴫ␎ࢆࠊᩘ⌮ⓗ࡞ゎᯒࢆᐇࡋ࡚࠸ࡿᮏࣉࣟࢪ࢙ࢡࢺ⌜ဨ♫
⛉Ꮫࢆᑓ㛛ࡍࡿ⌜ဨᥦ౪ࡋ࡚ࡁࡓࠋᢠ࢘ࣝࢫస⏝ࡢ࠶ࡿ⣲ᮦࡢ㛤Ⓨࡶᘬࡁ⥆ࡁດຊࡋ࡚࠾
ࡾࠊ୍ᐃࡢᡂᯝࢆฟࡍࡇࡀ࡛ࡁࡓࠋ◊✲௦⾲⪅ࡢᵳࡣࠊ♫⛉Ꮫⓗ࡞ഃ㠃ࡽࠊᮏ◊✲ࣉࣟࢪ
࢙ࢡࢺⓎ㊊௨᮶ᵝࠎ࡞ሙᡤ࡛ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨࢆど㔝ධࢀࡓࠊ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ㫽
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㛵ࡋ࡚ࡇࢀࡲ࡛ᚓࡽࢀࡓ◊✲ᡂᯝࠊ࠶ࡿ࠸ࡣ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ
᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢⓎ⏕ཬࡧୡ⏺ⓗ࡞ᗈࡀࡾ㛵ࡍࡿ᭱᪂ࡢሗࢆࠊ୍⯡ᕷẸࢆྵࡴྛ᪉㠃ᖜ
ᗈࡃᥦ౪ࡋ࡚ࡁࡓࠋ ᖺ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀฟ⌧ࡋࡓ㝿ࡣࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢ≉ᚩࠊ
ࡑࡢ㏻ᖖࡢ᪥ᖖ⏕άཬࡰࡍᙳ㡪ࠊཬࡧࡑࡢᑐᛂ⟇☜❧ࡘ࠸࡚ࠊᖜᗈ࠸ၨⵚάືບࢇ࡛࠸ࡿࠋ
ࡍ࡞ࢃࡕࠊ ሗࡢ◊✲ㄽᩥࡢࠊ ሗࡢⴭ᭩ࠊ⥲ㄝࠊゎㄝ᭩ࢆබ⾲ࡋ࡚ࡁࡓࠋࡲࡓࠊ ᅇཬࡪ
ㅮ₇ࢆᐇࡋ࡚ࡁࡓ㸦ᵳࠊ㧘᱓ࠊᖖᅧࠊୖࠊ⸭⏣ࠊ℩ᑿ㸧ࠋ
◊✲ㄽᩥ㸦㸨㹼㸨࣭㸨࣭㸨࣭㸨㸧ᅗ᭩㸦㸨㹼㸨㸧ᏛⓎ⾲㸦㸨㹼㸨࣭㸨࣭㸨࣭
㸨࣭㸨㹼㸨࣭㸨࣭㸨࣭㸨࣭㸨࣭㸨࣭㸨࣭㸨㹼㸨㸧ㅮ₇㸦㸨㹼㸨㸧
㻌 ♫⛉Ꮫⓗ࡞ഃ㠃ࡽࡣࠊࡇࢀࡲ࡛⤖᰾ឤᰁࡋࡓேࡀ⿕ࡿྍ⬟ᛶࡢ࠶ࡿேᶒᢚไࡢᐇែᢕᥱཬ
ࡧࡑࡢᑐ⟇࡞ྛ✀ឤᰁᝈ⪅ࡢேᶒಖㆤࢆࠊἲᚊᐙࡢ❧ሙࡽ⾜ᨻ༠ຊࡋ࡞ࡀࡽ㐍ࡵ࡚ࡁࡓࠋ
ᅇࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀฟ⌧ࡍࡿ๓ࡽࠊᩘ㔞ࡀ㊊ࡍࡿࡇࡀᠱᛕࡉࢀ࡚ࡁࡓ᪂ᆺࣥࣇࣝ
࢚ࣥࢨ࣡ࢡࢳࣥࡢ᥋✀㡰ࡘ࠸࡚ࠊேᶒ㓄៖ࡋ࡞ࡀࡽ⪃࠼ࡿᚲせᛶࢆ⾲᫂ࡋࠊ♫ⓗ࡞άືࡀ
ไ⣙ࡉࢀ࡞࠸᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ࡢἲᩚഛࠊᏛᰯ➼ࡢᩍ⫱ᶵ㛵ࡀ᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ࢆㅮ
ࡎࡿࡓࡵࡢἲᩚഛྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ༢࡞ࡿἲᚊᏛⓗ࡞❧ሙࡽ࡛࡞ࡃࠊ⮬↛⛉Ꮫⓗ࡞᳨ウࡢ⤖ᯝ
ᚓࡽࢀࡓࡼࡾᖜࡢᗈ࠸▱ぢࢆᇶ♏⨨࠸ࡓྲྀࡾ⤌ࡳࡀࠊྍ⬟࡛࠶ࡿࡇࡀᮏ◊✲ࣉࣟࢪ࢙ࢡࢺࡽ
ド᫂ࡉࢀࡓࠋឤᰁᑐ⟇ಀࡿᅜᐙཬࡧᆅ᪉⾜ᨻࡢឤᰁᑐ⟇㛵ࢃࡿ㔜せ࡞ጤဨጤဨࡋ࡚
ᢤ᧻ࡉࢀࠊἲᚊᐙࡢ❧ሙࡽ⮬↛⛉Ꮫ㠃ࡽ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ᪂ᆺࣥࣇ࢚ࣝࣥࢨྲྀࡾ
⤌ࢇ࡛࠸ࡿᵳࡽ⮬↛⛉Ꮫศ㔝ࡢ◊✲⌜ဨࡢᐦ᥋࡞༠ྠయไࢆࡾࠊࡼࡾ᭷ຠ࡞ឤᰁ㜵ᑾ
ຊࡋ࡚࠸ࡿ㸦ᕝᮏ㸧ࠋ
◊✲ㄽᩥ㸦㸨㹼㸨㸧ᏛⓎ⾲㸦㸨㸧ㅮ₇㸦㸨㹼㸨㸧
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ࠶ࡿ࠸ࡣ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣ⏕≀රჾ࠶ࡿ࠸ࡣࣂ࢜ࢸࣟ
ࡢ㐨ල⏝ࡉࢀࡿᜍࢀࡶ࠶ࡿࡓࡵࠊࡑࡢほⅬࡽᅜእࡢ≧ἣࡢᢕᥱ㗦ពࡵ࡚࠸ࡿࠋᏛරჾࠊ
⏕≀රჾ࠶ࡿ࠸ࡣࣂ࢜ࢸࣟᑐ⟇ࡢୡ⏺ⓗᶒጾ࡛࠶ࡿࢥࣟࣛࢻᕞ❧Ꮫྡᩍᤵࡢࣥࢯࢽ࣮ᮭ༤
ኈࡢ᥋ゐࢆጞࡵࡿ⮳ࡗ࡚࠸ࡿࠋࡲࡓࠊࡇࢀࡽࢆ㢟ࡋࡓㅮ⩏ࢆࠊ㫽ྲྀᏛ㎰Ꮫ㒊⋇་Ꮫ⛉࠾
ࡼࡧᒱ㜧Ꮫᛂ⏝⏕≀Ꮫ㒊⋇་Ꮫㄢ⛬ࠊி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊ື≀⏕་⛉Ꮫ⛉Ꮫ⏕ᑐ
ࡋ࡚ࢸࣞࣅㅮ⩏ࢆᐇࡋ࡚࠸ࡿ㸦ᒾᮏ㸧ࠋ
୍᪉ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢᛶ≧ࢆᢕᥱࡋ࡞ࡀࡽࠊឤᰁࡢఏ㛵ࡍࡿᇶᮏⓗ࡞ᩘ⌮
ࣔࢹࣝ㛵ࡍࡿ◊✲ࡢࢧ࣮࣋ࡶᐇࡋ࡚࠸ࡿࠋ✵㛫ⓗ࡞ఏࢆ⪃ᐹࡍࡿࡓࡵࡢࣔࢹࣝࡋ࡚ࠊᣑ
ᩓᛂࣔࢹࣝࠊ✚ศ᪉⛬ᘧࣔࢹࣝࠊࢿࢵࢺ࣮࣡ࢡࣔࢹࣝ➼ࡢ≉ᚩࢆ⪃ᐹࡋ࡚࠸ࡿࠋ㠀ᖖ⡆༢࡛ᇶ
♏ⓗ࡞ࣔࢹࣝࡢᩘ⌮ゎᯒࡽึࡵ࡚࠸ࡿࡀࠊ ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀணࡋࠊ
᪩ᮇᚑ᮶ࡢᏘ⠇ᛶࣥࣇ࢚ࣝࣥࢨኚࢃࡗ࡚ࡋࡲࡗࡓࡓࡵࠊ◊✲ࡣึᮇẁ㝵ࡲࡗ࡚࠾ࡾࠊ
ࡁ࡞㐍ᒎࡣㄆࡵࡽࢀ࡚࠸࡞࠸㸦⣽㔝㸧ࠋ
◊✲ㄽᩥ㸦㸨㸧ᏛⓎ⾲㸦㸨㸧ㅮ₇㸦㸨㸧
㻌 ࢘ࣝࢫࡢឤᰁࢆཷࡅࡿ⏕యഃࡽࡢ◊✲ࡶ㐍ᒎࡋࡓࠋ⫵ࡢච⣔࠾ࡅࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪ
ࡢ࡞ᶵ⬟ࡣࠊ࢘ࣝࢫࡸ⣽⳦ឤᰁࡢึᮇ㜵ᚚᶵ⬟࡛࠶ࡿ㈎㣗స⏝ࠊࡢච⣔⣽⬊ࢆάᛶࡉࡏ
ࡿࢧࢺ࢝ࣥࡢ⏘⏕ࠊ7 ⣽⬊ࡢᢠཎᥦ♧ᶵ⬟࡛࠶ࡾࠊ⫵࡛ࡢ࢘ࣝࢫ࣭⣽⳦ឤᰁᑐࡋ࡚ឤᰁ
㜵ᚚࡢ୰ᚰⓗ࡞ᙺࢆࡋ࡚࠸ࡿࠋႚ↮ࡣࠊච⣽⬊ࡢᶵ⬟ᙳ㡪ࡍࡿࡇࡀ▱ࡽࢀ࡚࠾ࡾࠊᢠ⭘⒆
⣽⬊άᛶࡢపୗࠊ% ⣽⬊ࡢ /36 ᛂࡢቑຍࠊ&RQ$ ࡀㄏᑟࡍࡿ ,/㸫㸰⏘⏕ࡢῶᑡཬࡧ 7 ⣽⬊ࡢ 0/5
ᛂࡢῶᑡ࡞ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡋࡋࠊႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ࢘ࣝࢫࠊ⣽⳦ࡢឤ
ᰁ㜵ᚚᶵ⬟ᢠయ⏘⏕ࡢ┦㛵ಀཬࡰࡍᙳ㡪㛵ࡋ࡚ࠊヲ⣽࡞ሗ࿌ࡣᑡ࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋ
ࡑࡇ࡛ࠊႚ↮ࡼࡿ࢘ࣝࢫ࣭ᚤ⏕≀࡞ࡢእ᮶ᢠཎᑐࡍࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ㈎㣗ᶵ⬟ࡑ
ࡢᚋࡢᢠయ⏘⏕ࡢᙳ㡪ࢆㄪࡿࡓࡵࠊ⨺㉥⾑⌫㸦65%&㸧ࢆᢠཎࡋ࡚⏝࠸᳨࡚ウࡋࡓࠋ㠀ႚ↮
⩌ẚ㍑ࡋ࡚ࠊႚ↮⩌ࡢ⫵⬊࣐ࢡࣟࣇ࣮ࢪ࡛ࡣᢠཎࡢྲྀࡾ㎸ࡳᶵ⬟࡛࠶ࡿ㈎㣗స⏝ࡢᢚไࡀㄆࡵ
ࡽࢀࠊࡑࡢᢚไࡣ㣗స⏝㛵㐃ࡋࡓᢠయࡢ࢜ࣉࢯࢽࣥࣞࢭࣉࢱ࣮࡛ࡣ࡞ࡃࠊ⿵యࡢ࢜ࣉࢯࢽࣥࣞࢭ
ࣉࢱ࣮ࡢⓎ⌧పୗࡼࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊႚ↮᭚㟢ࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡣࠊᢠయ
⏘⏕ࡢึᮇ㐣⛬࡛࠶ࡿᮍ⇍࡞㹀⣽⬊ᶵ⬟ᑐࡋ࡚ᢚไⓗാࡁࠊ᪤ᢠయࢆ⏘⏕ࡋ࡚࠸ࡿᡂ⇍ࡋࡓ
㹀⣽⬊ࡣࠊᢚไⓗ࡞ᙳ㡪ࢆ♧ࡉ࡞ࡗࡓࠋࡇࢀࡽࡢᡂ⦼ࡽࠊႚ↮ࡣ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢᢠཎ
−7−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ྲྀࡾ㎸ࡳ㛵ಀࡋࡓ㈎㣗άᛶࠊࡑࢀᘬࡁ⥆࠸࡚㉳ࡇࡿᮍ⇍㹀⣽⬊ࡢᢠయ⏘⏕ࡢึᮇ㐣⛬ᢚไⓗ
ാࡁࠊࡑࡢ⤖ᯝᢠయ⏘⏕ࢆᢚไࡋ࢘ࣝࢫ࣭⣽⳦࡞ࡢ᫆ឤᰁᛶࢆቑຍࡉࡏࡿྍ⬟ᛶࡀ♧၀ࡉࢀ
ࡓࠋႚ↮ࡼࡾᶵ⬟ⓗᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡀㄏᑟࡉࢀࡓࠋࡲࡓࠊࣥࣇ࢚ࣝࣥࢨ࢘
ࣝࢫ +1 ᰴឤᰁࡼࡾࠊ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ⣽⬊ෆᵓ㐀ࡢയᐖࡀほᐹࡉࢀࡓࠋࡲࡓࠊ⻏⻤ࠊ࢟ࣀ
ࢥᢳฟᾮ⫵⬊࣐ࢡࣟࣇ࣮ࢪࠊ⫵ㄏᑟࡉࢀࡓዲ୰⌫ᶵ⬟ࢆάᛶࡉࡏࡿస⏝ࡀ࠶ࡿࡇࡀㄆࡵ
ࡽࢀࠊணᐃ◊✲ィ⏬ࡢᇶ♏ⓗ࡞ィ⏬ࡘ࠸࡚ࡣࡰ㐩ᡂฟ᮶ࡓࠋࡲࡓࠊ㫽ࣥࣇ࢚ࣝࣥࢨ +1 ᰴ
ࡘ࠸࡚ࡶࠊ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢᙳ㡪ࢆ᳨ウࡋࡓࡀࠊࢧࢺ࢝ࣥࡢ⏘⏕ࡣᙳ㡪ࡀㄆࡵࡽࢀ࡞
ࡗࡓࠋᚋࠊࡇࡢ㸳ᖺ㛫ࡢᇶ♏ⓗ࡞◊✲ᡂᯝࢆࡶࠊච⣽⬊ࢆάᛶࡉࡏࠊᢠ࢘ࣝࢫస⏝
ࢆ᭷ࡍࡿ⣲ᮦࡢ㛤Ⓨ➼㛵ࡍࡿᛂ⏝◊✲㐍ࡴணᐃ࡛࠶ࡿ㸦➉ෆ㸧
ࠋ
◊✲ㄽᩥ㸦㸨㹼㸨㸧ᏛⓎ⾲㸦㸨㹼㸨㸧
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁ㛵ࢃࡿࡉࢀࡿࢩࣝ㓟ྵ᭷⢾㙐ࢆከ㔞᭷ࡍࡿ⭷ࢱࣥࣃࢡ㉁
࡛࢘ࣝࢫཷᐜయࡢྍ⬟ᛶࡀ࠶ࡿ &' ᑐࡍࡿᢠయࢆ⏝࡛ࡁࡿࠊࣛࢵࢺࣄࢺࡢᇵ㣴⣽⬊ࡸ⤌⧊
ࡽ &' ࡢ⢭〇ࢆヨࡳࡓࠋࣛࢵࢺ㛵ࡋ࡚ࡣࠊ3&⣽⬊࡛࣏ࣜࣛࢡࢺࢧ࣑ࣥࢆྵ᭷ࡍࡿせ⢾ࡓ
ࢇࡥࡃ㉁ࡢ㸯ࡘ࡛࠶ࡿࡇࢆㄆࡵࡓ &' 㦵㧊ࡸ⬻ࡢ &' ࢆࠊ⁐፹ࡼࡿ㑅ᢥⓗ࡞ᢳฟ
'($(̺ࢭ࣮ࣝࣟࢫ࢜ࣥࢡ࣐ࣟࢺࢢࣛࣇ࣮࡞ࢆ⏝࠸࡚ &' ௨እࡢࢱࣥࣃࢡ㉁ࢆࢇ
ྵࡲ࡞࠸ࡲ࡛⢭〇ࡋࡓࠋࡑࡋ࡚ࠊ⢭〇ࡉࢀࡓ &' ࢆ⢾㙐࣐ࢡࣟࣞࡢᢏ⾡ࢆᛂ⏝ࡋ࡚ࢽࢺࣟ
ࢭ࣮ࣝࣟࢫ⭷ᅛ┦ࡋ࡚ᢠయࡸࣞࢡࢳࣥ࡞ࡢ⤖ྜࢩࢢࢼࣝࢆ᳨⣴ࡍࡿࡇࡼࡾࠊ&' ศᏊୖ
ࡢ⢾㙐ࡢᵓ㐀ࢆỴᐃࡋࡓࠋࡑࡢ⤖ᯝࠊ3& ⣽⬊㦵㧊࡛ࡣ⢾㙐ࡢᵓ㐀ࡣ㢮ఝࡋࠊ࣏ࣜࣛࢡࢺࢧ࣑ࣥ
㙐ࡢࠊࢩࣝ㓟ࡀȘ ⤖ྜࡸȘ ⤖ྜࡋࡓ⢾㙐ࡀㄆࡵࡽࢀࠊ⏕యෆ࡛ࡢࣥࣇ࢚ࣝࣥࢨ࢘
ࣝࢫࡢཷᐜయ࡞ࡾ࠺ࡿྍ⬟ᛶࡀㄆࡵࡽࢀࡓࠋ௨ୖࡢ⤖ᯝࠊᙜึࡢ◊✲┠ᶆࢆ㐩ᡂࡍࡿࡇࡀ࡛ࡁ
ࡓ㸦⚟㸧ࠋ
◊✲ㄽᩥ㸦㸨㸧ᏛⓎ⾲㸦㸨㸧
Ϩ㸬ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᶵᵓࡘ࠸࡚
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢࡓࡿධ㒊ࡋ࡚ࡣࠊ⢓⭷ୖ⓶ࡀᣲࡆࡽࢀࡿࠋྠ㒊ࡢ⣽⬊⾲㠃ࡣ
࣒ࢳࣥࡤࢀࡿ⢾ࢱࣥࣃࢡ㉁そࢃࢀ࡚࠸ࡿࠋ୰࡛ࡶ⭷⤖ྜᆺ࣒ࢳࣥࡢ ࡘ࡛࠶ࡿ 08& ࡣ᭱ࡶᬑ
㐢ⓗᏑᅾࡍࡿ࣒ࢳ࡛ࣥ࠶ࡿࠋ୍⯡ⓗ࣒ࢳࣥࡣࢩࣟࢢࣜ࢝ࣥᐩࡳࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
ࡢཷᐜయ࡞ࡿྍ⬟ᛶࡀ㧗࠸ணࡉࢀࡓࠋ⣽⬊ࡋ࡚ࡣࠊ⫵ୖ⓶⏤᮶⣽⬊ᰴ࡛࠶ࡿ $ ⣽⬊ࢆ⏝
࠸ࡓࠋྠ⣽⬊ࡣ 08& ࢆపⓎ⌧ࡋ࡚࠸ࡿࡇࢆ )$&6 ࡛☜ㄆࡋࡓࠋࡉࡽ 08&F'1$ ࢆᑟධࡋࠊ08&
㧗Ⓨ⌧ᰴ㸦$+㸧ࢆᚓࡓࠋࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡋ࡚ࡣࠊ3DQDPD ཬࡧ 35 ᰴࢆ⏝࠸ࡓࠋ
㸧 ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⏘⏕㔞ࡢẚ㍑
$ ཬࡧ $+ ⣽⬊ 3DQDPD ࠶ࡿ࠸ࡣ 35 ᰴ+$ࢆ 㛫ឤᰁᚋࠊᇵ㣴ᾮࢆࡋࠊ ᪥㛫
࣮ࣥ࢟ࣗ࣋ࢺࡋࡓࠋᇵ㣴ୖΎࡢ࢘ࣝࢫ㔞ࡣࠊ$$+ ⣽⬊࠾࠸࡚ࠊ3DQDPDࠊ35 ᰴࡑࢀࡒࢀࠊ
$+ ⣽⬊ࡢ᪉ࡀࠊ⣙ ཬࡧ ಸࡢ 7&,' ್ࢆ♧ࡋࡓࠋࡲࡓࠊྠᵝࠊ 㛫ឤᰁᚋࠊᇵ㣴ୖΎ୰
ᨺฟࡉࢀࡿ࢘ࣝࢫࡣࠊ⣙ 㛫ᚋࡼࡾ᳨ฟࡉࢀࠊࡑࡢᚋ $+ ⣽⬊࠾࠸࡚ⴭࡋࡃୖ᪼ࡋࡓࡀࠊ
$ ⣽⬊࡛ࡣቑ࡛࠶ࡗࡓࠋࡇࢀࡽࡢ⤖ᯝࡣࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁ 08& ࡀ㛵ࡋ
࡚࠸ࡿࡇࢆᙉࡃ♧၀ࡋࡓࠋࡲࡓࠊ⣽⬊ෆ࠾ࡅࡿ 13 ࢱࣥࣃࢡ㉁㔞ࡣ୧⣽⬊࠾࠸࡚ࡁ࡞ᕪࡣㄆ
ࡵࡽࢀ࡞ࡗࡓࠋ
㸧 ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫཷᐜయࡢ᳨⣴
࢘ࣝࢫࡢཷᐜయࢆ᳨⣴ࡍࡿ┠ⓗ࡛ࠊ$+ ⣽⬊ࡢࣛࢭ࣮ࢺࢆㄪ〇ࡋࠊ6'63$*( ᚋࠊ=HWD ࣉ࣮ࣟ
ࣈ⭷࢚࢘ࢫࢱࣥࣈࣟࢵࢸࣥࢢࢆ⾜ࡗࡓࠋ3DQDPD ཬࡧ 35 ᰴࡢ࢘ࣝࢫ⾲㠃ࢱࣥࣃࢡ㉁ࢆࣅ࢜ࢳ
࡛ࣥᶆ㆑ࡋࠊ=HWD ࣉ࣮ࣟࣈ⭷࣮ࣥ࢟ࣗ࣋ࢺࡋࡓࠋὙίᚋࠊࢫࢺࣞࣉࢺࣅࢪࣥ+53 ࢆ⏝࠸࡚Ⓨ
Ⰽࡋࡓࠋ࠸ࡎࢀࡢ࢘ࣝࢫࡶ N'D ௨ୖࡢࢫ࣑࣮ࣖ≧ࡢ㧗ศᏊ⢾ࢱࣥࣃࢡ㉁⤖ྜࡋࡓࠋᢠ 08&
ᢠయࡼࡿ᳨ฟࡼࡾࠊྠࣂࣥࢻࡀ 08& ࡛࠶ࡿࡇࢆ☜ㄆࡋࡓࠋࡲࡓࠊ⭷ୖࡢ࣒ࢳࣥࢆࢩࣜࢲ࣮
ࢮฎ⌮ࡍࡿࡇࡼࡾࠊࡑࡢ⤖ྜࡀᾘኻࡍࡿࡇࡽࠊ࢘ࣝࢫࡣ 08& ୖࡢࢩࣝ㓟≉␗ⓗ⤖
ྜࡋ࡚࠸ࡿࡇࡀࢃࡗࡓࠋ
㸧 ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁక࠺ 08& ࡢኚ
୍⯡ⓗࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣࠊࢩࣟࢢࣜ࢝ࣥ⤖ྜᚋࠊ⣽⬊ෆྲྀࡾ㎸ࡲࢀࠊᨺฟࢩ
ࣝ㓟ࢆษ㝖ࡋ࡚㐟㞳ࡍࡿࡉࢀ࡚࠸ࡿࠋឤᰁᚋࠊ⤒ⓗ⣽⬊ࡢࣛࢭ࣮ࢺࢆㄪ〇ࡋࠊ㟁ẼὋື
ࡼࡾ 08& ࡢศᏊࢧࢬࡢኚࢆぢࡓࠋ࡞࠾ࠊ08& ࡢࢩࣝ㓟ࡀษ㝖ࡉࢀࡿ㟁ẼὋືୖ࡛ࡣ㝜
ᛶⲴ㟁ࡢῶᑡࡼࡾࠊ⛣ື⬟ࡀపୗࡋࠊぢࡅୖ㧗ศᏊࡍࡿࡇࡀࢃࡗ࡚࠸ࡿࠋឤᰁᚋ 㛫
⛬ᗘࡲ࡛ࡣࠊ08& ኚࡣぢࡽࢀ࡞ࡗࡓࡀࠊ 㛫ࢆ㉸࠼ࡿ㧗ศᏊࡋࠊࢩࣝ㓟ࡀษ㝖ࡉࢀ
−8−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ࡿࡇࡀࢃࡗࡓࠋྠ 31$ ࣞࢡࢳࣥࡢ⤖ྜࡀቑࡋࠊࢩࣝ㓟ࡀษ㝖ࡉࢀ࢞ࣛࢡࢺ࣮ࢫࡢ㟢ฟࡀ
ࡅࡽࢀࡓࠋ08& ࢆ LQ YLWUR ࡛⬺ࢩࣝࡋࡓヨᩱࡶὋືᗘࡀ୍⮴ࡍࡿࡇࡽࠊ࢘
ࣝࢫࡢ 1$ ࡼࡾࡰࡍ࡚ࡢࢩࣝ㓟ࡀឤᰁ㝖ཤࡉࢀࡓࡇࢆ♧ࡋ࡚࠸ࡿࠋ࢚ࣥࢻࢰ࣮࣒ࡸ
ࣜࢯࢰ࣮࣒ࡢᡴࡕࢱࣥࣃࢡ㉁࡛࠶ࡿ /$03ࠊ ࡘ࠸࡚ࡶࠊྠᵝឤᰁ⬺ࢩࣝࡀ㉳ࡇࡿ
ࡽࠊ࢘ࣝࢫࡢධక࠸ࠊ࢚ࣥࢻࢧࢺ࣮ࢩࢫ⣽⬊ෆࡢ㝈ࡽࢀࡓࢥࣥࣃ࣮ࢺ࣓ࣥࢺ࡛ຠ
⋡ⓗࢩࣝ㓟ࡀ㝖ཤࡉࢀ࡚࠸ࡿࡇࢆ♧၀ࡋ࡚࠸ࡿࠋ
㸧 ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁక࠺ሗఏ㐩
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᚋࡢ 08& ࢆࡋࡓሗఏ㐩ࡘ࠸࡚ࠊ(5.Sཬࡧ $NW ࡢࣜࣥ㓟
ࡘ࠸᳨࡚ウࡋࡓࠋࡍ࡞ࢃࡕࠊ࢘ࣝࢫឤᰁᚋࡢ $ ཬࡧ $+ ⣽⬊ࡼࡾࠊ⤒ⓗ⣽⬊ࡢࣛࢭ
࣮ࢺࢆㄪ〇ࡋࠊ6'63$*(ࠊ࢚࢘ࢫࢱࣥࣈࣟࢵࢸࣥࢢᚋᢠࣜࣥ㓟 (5. ᢠయࠊᢠࣜࣥ㓟 S ᢠ
యࠊᢠࣜࣥ㓟 $NW ᢠయࢆ⏝࠸᳨࡚ฟࡋࡓࠋឤᰁᚋࡢẚ㍑ⓗ▷㛫ෆࡢࢩࢢࢼࣝఏ㐩ࡘ࠸࡚ࡣࠊ
୧⣽⬊࠾࠸࡚᭷ពࡢ⤖ᯝࡣᚓࡽࢀ࡞ࡗࡓࠋᚑࡗ࡚ࠊ08& ࡣ࢘ࣝࢫࡢྲྀࡾ㎸ࡳࡢࡳ㛵ࡋ࡚
࠸ࡿࡶࡢணࡉࢀࡿࠋࡋࡋ࡞ࡀࡽࠊឤᰁᚋ 㛫⛬ᗘ⤒㐣ࡋࡓ୧⣽⬊ࡘ࠸࡚ࠊ(5. ཬࡧ S
ࡘ࠸࡚ᕪ␗ࡣㄆࡵࡽࢀ࡞ࡗࡓࡀࠊ$NW ࡘ࠸࡚┦㐪ࡀㄆࡵࡽࢀࡓࠋࡍ࡞ࢃࡕࠊ$NW ࡢࣜࣥ㓟ࡀࠊ
$ ⣽⬊ࡢ᪉ࡀ $+ ⣽⬊ࡼࡾஹ㐍ࡋࠊࡑࡢഴྥࡣ 㛫⛬ᗘࡲ࡛ぢࡽࢀࡓࠋ$NW ࡢάᛶࡣ࣏
ࢺ࣮ࢩࢫࢆᢚไࡍࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࡇࡽࠊࣛࢭ࣮ࢺࡢ㟁ẼὋືཬࡧ࢚࢘ࢫࢱࣥࣈࣟࢵࢸ
ࣥࢢᚋ࢝ࢫࣃ࣮ࢮ㸱ࡢάᛶࢆẚ㍑ࡋࡓࡇࢁࠊ$+ ⣽⬊ࡢ᪉ࡀ㧗ࡃࠊ࣏ࢺ࣮ࢩࢫࡀ $+
⣽⬊࡛ಁ㐍ࡋ࡚࠸ࡿࡇࡀࢃࡗࡓࠋࡲࡓࠊ781(/ ἲࡼࡿ⣽⬊ᰁⰍࡼࡗ࡚ࡶ $+ ⣽⬊࡛࣏
ࢺ࣮ࢩࢫࡀஹ㐍ࡋ࡚࠸ࡿࡇࡀࢃࡗࡓࠋᚑࡗ࡚ࠊ08& 㧗Ⓨ⌧⣽⬊ᰴ࡛ࡣࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝ
ࢫࡢឤᰁᚋࠊ$NW ࡢάᛶࡀ 08& పⓎ⌧ᰴࡼࡾᢚไࡉࢀࡿ⤖ᯝࠊ࣏ࢺ࣮ࢩࢫࡀ㉳ࡇࡾࠊࡼࡾከࡃ
ࡢ࢘ࣝࢫ⢏Ꮚࡀᇵ㣴ୖΎᨺฟࡉࢀࡓࡶࡢ⪃࠼ࡽࢀࡿࠋ࡞࠾ࠊ࢘ࣝࢫࢱࣥࣃࢡ㉁ࡢ ࡘ࡛࠶
ࡿ 16 ࡶ 08& 㧗Ⓨ⌧ᰴ࡛ῶᑡࡋ࡚࠸ࡿࡇཬࡧ 16 ࡣ 3,. ࢆάᛶࡍࡿࡇࡽ 08&, 16 ࡢ㛵
㐃ᛶࡘ࠸᳨࡚ウ୰࡛࠶ࡿࠋ㸦୰⏣ࠊ⛅⏣ࠊୖࠊᮌࠊ▼⏣㸧ࠋ
◊✲ㄽᩥ㸦㸨㹼㸨㸧ᅗ᭩㸦㸨㹼㸨㸧ᏛⓎ⾲㸦㸨㹼㸨㸧
㻌 ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⢏Ꮚෆ㒊ࢱࣥࣃࢡ࡛࠶ࡿ3%ࡢ୰㛫ࢻ࣓ࣥ㡿ᇦ㸦㸧ࢆ3&5ࡼࡗ
࡚ቑࡸࡋࠊS(7EⓎ⌧࣋ࢡࢱ࣮ᑟධࡋࠊ%/5,/ࢥࢵࢺࣥࣉࣛࢫࢥࣥࣆࢸࣥࢺࢭ࡛ࣝⓎ⌧ࡋࡓࠋ
1L࣒࡛࢝ࣛ⢭〇ࡋࠊP07ULV+&O3+ࠊP01D&OP0'77ࡢࣂࢵࣇ࣮᮲௳࡛ࠊPJPOࡢ⃰
ᗘࡲ࡛ࢱࣥࣃࢡ㉁ࢆ⃰⦰ࡋࡓࠋ1D&OࢆỿẊࡋ࡚⤖ᬗࡀᚓࡽࢀࡓࠋ㠀⤖ᬗᏛⓗᑐ⛠༢ศᏊ
ධࡗ࡚࠸ࡿ⤖ᬗ࡛ࠊศゎ⬟ύࡢࢹ࣮ࢱࢆᚓࡓࠋ✵㛫⩌ࡣ3㸰㸯㸰㸯㸰㸯
㸦D ύE ύF ύ㸧࡛࠶ࡾࠊ5IDFWRU 5IUHH ࡢᵓ㐀ࢆゎ᫂ࡋࡓࠋࡉ
ࡽࠊ3%㛗ࡢᵓ㐀ゎᯒࢆ┠ᣦࡋ࡚ࠊ㛗ࡢⓎ⌧ࡶ⾜ࡗ࡚࠸ࡿ㸦ὠୗࠊ㭯ᮧ㸧ࠋ
㻌 ◊✲ㄽᩥ䠄䠆㻡㻜䡚䠆㻡㻡䠅ᏛⓎ⾲䠄䠆㻤㻣䡚䠆㻥㻥䠅㻌
㻌
䠘ඃ䜜䛯ᡂᯝ䛜䛒䛜䛳䛯Ⅼ䠚㻌
ᑗ᮶ฟ⌧ࡍࡿྍ⬟ᛶࡢ࠶ࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ✀㢮ཬࡧฟ⌧ࡍࡿᆅᇦࢆ᥎ᐃ࡛ࡁࡿྍ
⬟ᛶࢆ⪃࠼ࠊᅜእࠊ≉࣋ࢺࢼ࣒ࡢ㔝እ࠾࠸࡚᥇㞟ࡉࢀࡓᮦᩱࢆ⏝࠸᳨࡚ウࡍࡿࡇࡀ࡛ࡁࡓࠋ
࣋ࢺࢼ࣒࠾࠸࡚ࡣࡇࢀࡲ࡛ +1 ࢘ࣝࢫࡢࡳࡀ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡋ࡚ㄆ㆑ࡉࢀ࡚࠸
ࡓࡀࠊᵝࠎ࡞ளᆺࡢ࢘ࣝࢫࡀ᪥ᮏࡢሙྜ␗࡞ࡾᐙࡁࢇ㢮࠶ࡿ࠸ࡣ㔝㫽ឤᰁࡋ࡚࠸ࡿࡇࡀึ
ࡵ࡚᫂ࡽ࡞ࡗࡓࠋࡇࢀࡽ +1 ࢘ࣝࢫ௨እࡢளᆺࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀࠊᑗ᮶ูࡢࢱ
ࣉࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫฟ⌧㛵ࡍࡿྍ⬟ᛶࡶ♧၀ࡉࢀࡿࠋࡲࡓࠊ᫂ࡽ࡞ᆙࣥࣇ
࢚ࣝࣥࢨ࢘ࣝࢫάᛶࢆ᭷ࡍᾘẘࡢ㛤Ⓨཬࡧⓗ☜࡞ホ౯ἲࡢ㛤Ⓨࡶᡂຌࡋ࡚࠸ࡿ㸦ᵳࠊ㧘᱓ࠊ
ᖖᅧࠊୖࠊ⸭⏣ࠊ℩ᑿ㸧ࠋ
♫⛉Ꮫ◊✲⪅࡛࠶ࡿᕝᮏࠊᒾᮏ୧ᩍᤵ⮬↛⛉Ꮫⓗ࡞◊✲ᡂᯝࡢሗࢆᥦ౪ࡋࡓࡇࡼࡾࠊ
᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᑐࡋࠊึࡵ࡚⌮ㄽⓗᐈほᛶࡢ࠶ࡿຠᯝⓗ࡞ᑐฎ᪉ἲࢆᵓ⠏ࡍࡿ┠
ฎࡀࡘ࠸ࡓࠋ⮬↛⛉Ꮫ◊✲⪅ࡢࡳ࡛ࡣࡇࡢࡼ࠺࡞⥲ྜⓗ࡞ヨࡳࡣ࡛ࡁ࡞ࡗࡓࠋ
᪉ࠊឤᰁࢆཷࡅࡿഃࡘ࠸࡚ࡢ◊✲ࡽࡶᗄࡘࡢඃࢀࡓ◊✲ᡂᯝࡀฟࡘࡘ࠶ࡿࠋ௨ୗ♧ࡍࠋ
ࡲࡎࠊႚ↮ࡼࡾ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡽάᛶ㓟⣲ࡢ㐣⏘⏕ࡀᘬࡁ㉳ࡇࡉࢀࠊ⏘⏕ࡉࢀࡓ㐣࡞
άᛶ㓟⣲ࡼࡾࠊ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢචᶵ⬟ࡀᢚไࡉࢀࠊචᶵ⬟ࡢᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ
࣮ࢪࡀㄏᑟࡉࢀࠊᶵ⬟ⓗᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡣࠊᘬࡁ⥆ࡃචᛂࢆᢚไࡋࠊ≉
7 ⣽⬊࡛ࡣ࡞ࡃᮍ⇍࡞㹀⣽⬊ࡢᢠయ⏘⏕ࡢึᮇㄏᑟᮇస⏝ࡋࠊ⤖ᯝⓗᢠయ⏘⏕ࢆᢚไࡍࡿࡇ
ࡀド᫂ࡉࢀࡓⅬ࡛࠶ࡿࠋࡲࡓࠊ⻏⻤࢘ࣝࢫࠊ⣽⳦ឤᰁࢆ㜵ᚚࡍࡿዲ୰⌫ᶵ⬟ࢆάᛶࡍࡿస⏝
−9−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ࢆ᳨ฟࡋࡓⅬ࡛࠶ࡿ㸦➉ෆ㸧ࠋ
ࢩࣝ㓟ྵ᭷⢾㙐ࢆከ㔞᭷ࡍࡿ⭷ࢱࣥࣃࢡ㉁࡛࢘ࣝࢫཷᐜయࡢྍ⬟ᛶࡀ࠶ࡿ &' ࡣࠊࡑࡢ⏕
≀Ꮫⓗ࡞ᙺࡸ 6'63$*( ࠾ࡅࡿከᵝᛶࡘ࠸࡚ࢇ᫂ࡉࢀ࡚ࡁࡓࠋᅇࡢ◊✲ࡽࠊ
&' ࡣⓎ⌧ᮇࡸⓎ⌧⣽⬊ࡼࡗ࡚ࡉࡲࡊࡲ⢾㙐ᵓ㐀ࢆኚࡉࡏ࡚࠸ࡿࡇࢆ᫂ࡽࡍࡿࡇ
ࡀ࡛ࡁࡓࡇࡣࡁ࡞㐍Ṍ࡛࠶ࡿࠋࡲࡓࠊ&' ࡢࡶࡘᏛⓗᛶ≧ࢆ⏝ࡋ࡚⡆౽࡛࠶ࡾ࡞ࡀࡽ⣧
ᗘࡢ㧗࠸ &' ࢆศ㞳⢭〇ࡍࡿ᪉ἲࢆ⪃ࡍࡿࡇࡀ࡛ࡁࡓ㸦⚟㸧
ࠋ
㻌 ⭷⤖ྜᆺ࣒ࢳ࡛ࣥ࠶ࡿ 08& ࡀࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཷᐜయࡋ࡚ᶵ⬟ࡍࡿࡇࢆึࡵ࡚
᫂☜♧ࡋࡓࠋ08& 㧗Ⓨ⌧ᰴ࡛ࡼࡾຠᯝⓗࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀ⏘⏕ࡉࢀࠊ⣽⬊እᨺฟࡉ
ࢀࡿࡇࢆ♧ࡍࡶࡑࡢศᏊⓗ⫼ᬒࡋ࡚ࠊ࣏ࢺ࣮ࢩࢫࡀㄏᑟࡉࢀࡿࡇࢆ♧ࡋࡓ㸦୰⏣ࠊ
⛅⏣ࠊୖࠊᮌࠊ▼⏣㸧ࠋ
3%㸰࣑ࢻࣝࢻ࣓ࣥࡣࣄࢺࡢ P51$ ࡢ &DS ᵓ㐀ࢆㄆ㆑ࡍࡿࢻ࣓࡛ࣥ࠶ࡾࠊP*73 ࡢඹ⤖ᬗᵓ㐀
ࡣࣇࣛࣥࢫࢢ࣮ࣝࣉࡼࡾゎ᫂ࡉࢀ࡚࠸ࡿࠋࡋࡋ࡞ࡀࡽࠊ᪂つࡢ⤖ᬗ࡛࠶ࡾࠊᵓ㐀ࡣ㔞యࢆ
ࡿࠋࡉࡽᡃࠎࡣඹྠ◊✲⪅㸦ᚨᓥᩥ⌮Ꮫ㸧ࡢࢢ࣮ࣝࣉ࡛ぢ࠸ࡔࡉࢀࡓࠊ3%㸰࣑ࢻࣝࢻ࣓ࣥࡢ
᪂つάᛶࢆᵓ㐀ࡽド᫂ࡍࡿࡓࡵࠊࡇࡢ⤖ᬗࢆ⏝࠸࡚㧗ศゎ⬟ࡢࢹ࣮ࢱ࡛ᵓ㐀ࢆゎ᫂ࡋࡼ࠺ࡋ
࡚࠸ࡿࠋࡇࡢ⏕Ꮫᵓ㐀◊✲ࡣࠊὀ┠್ࡍࡿ◊✲࡛ࠊㄽᩥᢞ✏୰࡛࠶ࡿ㸦ὠୗ㸧ࠋ
㻌
䠘ၥ㢟Ⅼ䠚㻌
ᮏ◊✲ࣉࣟࢪ࢙ࢡࢺ⏦ㄳࡣ␗࡞ࡿࢱࣉࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀฟ⌧ࡋࡓࠋࡑࡢ࢘
ࣝࢫࡢேࡢឤᰁຊཬࡧཎᛶࡶᅜ࡛ணࡉࢀ࡚࠸ࡓࡶࡢࡣ␗࡞ࡗ࡚࠸ࡓࠋ◊✲ᙜึࡣ␗࡞
ࡿែࡀ⏕ࡌࡓࡇࡁ࡞ၥ㢟ⅬࡀᏑᅾࡋࡓࡇࡣᐇ࡛࠶ࡿࠋࡋࡋࠊ⌧ᅾ෭㟼ࡇࡢ᪂ᆺ
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡘ࠸࡚ࡢホ౯ࢆ⾜ࡗࡓࠋࡇࡢ࢘ࣝࢫࡢᑗ᮶ീࡘ࠸࡚ࡶᗄࡘࡢྍ⬟ᛶ
ࢆ⪃࠼࡞ࡀࡽࠊ᳨ウࢆ㐍ࡵࡓࡀࠊணእே㢮ࡢ⬣ጾࡢᗘྜ࠸ࡣῶࡌࡓࠋࡋࡓࡀࡗ࡚ࠊᚋ࠸
࡞ࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀฟ⌧ࡍࡿࠊᗄࡘࡶࡢࢩࢼࣜ࢜ࢆไసࡋ࡚࠾ࡃࡇࡀồࡵࡽࢀ࡚࠸ࡿࠋ
ᩘ⌮⣔ཬࡧ♫⛉Ꮫ⣔ࡢ◊✲⪅ࡀ࠶ࡽࡌࡵ࣓࣮ࢪࡋ࡚࠸ࡓീࡢಟṇࠊ⮬↛⛉Ꮫศ㔝ࡢ◊✲⪅
ࡀ༠ຊࡍࡿࡇࡼࡗ࡚ࠊࡼࡾᐈほᛶࡢ㧗࠸ᑗ᮶ീࢆᙧᡂࡋ࡚ࠊṇࡋ࠸◊✲ࡢ᪉ྥᛶࢆ┠ᣦࡍࡇ
ࡀᙉࡃồࡵࡽࢀ࡚࠸ࡿࠋ
ᅜእ࠾ࡅࡿ㫽ࢆྵࡵࡓື≀ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢศᕸ≧ἣࢆࡉࡽヲ⣽ㄪ࡚ࠊᑗ᮶
ࡢࡼ࠺࡞ື≀ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀࠊே㢮⬣ጾࢆ࠼ࡿࡼࡾṇ☜࡞ண ࢆ❧࡚ࡿᚲせᛶ
ࡀࠊ௨๓ẚ࡚㧗ࡲࡗࡓ㸦ᵳࠊ㧘᱓ࠊ⸭⏣㸧ࠋ
⌧ᐇࠊឤᰁᩘ⌮ࣔࢹࣝࡢࡶࡘᛶ㉁ࢆゎ᫂ࡍࡿࡓࡵࡣࠊᩘ⌮ゎᯒࡢࡳ࡞ࡽࡎᩘ್ࢩ࣑࣮ࣗࣞ
ࢩࣙࣥࡀྍḞ࡛࠶ࡾࠊࡑࡢࣉࣟࢢ࣒ࣛ㛤Ⓨࡀィ⏬㏻ࡾ㐍ࡲ࡞ࡗࡓࡓࡵࠊᚋࠊࡢ◊✲⪅ࡢ༠
ຊࡶᚓ࡚ྲྀࡾ⤌ࡴᚲせᛶࡀࡼࡾ㔜せ࡞ࡗࡓ㸦⣽㔝㸧ࠋ
ᅇᾋࡧୖࡀࡗࡓၥ㢟Ⅼࡋ࡚ࠊႚ↮ࡼࡾㄏᑟࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ㑇ఏᏊኚ␗㫽
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆ⏝࠸࡚ࡢឤᰁᐇ㦂ࢆ⾜ࢃࡡࡤ࡞ࡽ࡞࠸ࠋࡇࡢⅬࡘ࠸࡚ࡣࠊ㹁㹅㹆ἲࢆ
⏝࠸࡚ࠊࡇࡢၥ㢟Ⅼࢆඞ᭹ࡍࡿࡇࡀྍ⬟࡛ࠊᚋࡇࡢⅬࡘ࠸࡚◊✲ࢆ㐍ࡵࡓ࠸ࠋឤᰁᐇ㦂ࡘ
࠸࡚ࡶࠊࡇࡢࡓࡧᩚഛࡉࢀࡓ 3ࠊ タࢆ⏝࠸࡚⾜࠺ࡇࢆணᐃࡋ࡚࠸ࡿ㸦➉ෆ㸧ࠋ
㻌 ឤᰁື≀࡛࠶ࡿ㭜㛵ࡋ࡚ࡣࠊ&' ࡢ㑇ఏᏊሷᇶ㓄ิࡀ᫂ࡽࡉࢀ࡚࠸࡞࠸ࡇࠊࡑࢀࢆㄆ
㆑ࡍࡿ≉␗ᢠయࡀ࡞࠸ࡇࢁၥ㢟Ⅼࡢ࠶ࡿࡇࡀุ᫂ࡋࡓࠋࡑࡇ࡛ࠊ㭜ࡢ % ⣽⬊⣔ࡢ⤌⧊࡛࠶ࡿ
ࣇࣈࣜ࢟࢘ࢫᄞ⚄⤒⣔ࡋ࡚⬻ࡽࠊ3& ⣽⬊࡛☜❧ࡋࡓ &' ࡢ⢭〇ἲࢆά⏝ࡋ࡚⢭〇ࢆ
ヨࡳࠊ㒊ศⓗ࡞࣑ࣀ㓟㓄ิࢆỴᐃࡋࠊ㭜࠾ࡅࡿ &' 㑇ఏᏊࡢ࣑ࣀ㓟㓄ิࢆ᳨⣴ࡍࡿࡶ
ࠊ㭜 &' ᑐࡍࡿᢠయࢆసᡂࡍࡿࡇࡼࡗ࡚ඞ᭹࡛ࡁࡓ㸦⚟㸧
ࠋ
㻌 ࢘ࣝࢫឤᰁక࠸ 08& 㧗Ⓨ⌧ᰴ࠾ࡅࡿ࣏ࢺ࣮ࢩࢫࡢㄏᑟࡘ࠸࡚ࠊ08& ࡢᅉᯝ㛵ಀࢆࡉ
ࡽ᫂☜ࡍࡿⅬࡀṧࡉࢀ࡚࠸ࡿࠋࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⏘⏕ࡍࡿࢱࣥࣃࢡ㉁࡛࠶ࡿ 16 ࡀ 08&
㧗Ⓨ⌧ᰴ࡛ῶᑡࡋࠊࡘ $NW ࢆάᛶࡍࡿࢱࣥࣃࢡ㉁࡛࠶ࡿࡇࡽࠊ16 08&ࠊࡾࢃࡅ 08&
ࡢ & ᮎࢻ࣓ࣥࡢ┦స⏝ศゎࡘ࠸࡚ゎỴࡢ⣒ཱྀࡀ࠶ࡿ⪃࠼࡚࠸ࡿ㸦୰⏣ࠊ⛅⏣ࠊୖࠊ
ᮌࠊ▼⏣㸧
ࠋ㻌
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢෆ㒊ࢱࣥࣃࢡ࡛࠶ࡿ 3% ࡢ㛗ࡢⓎ⌧⌧ᅾྲྀࡾ⤌ࢇ࡛࠸ࡿࠋࡇࡢ
⭠⳦࡛ࡢⓎ⌧ࡣ㞴ࡋ࠸ࡀࠊෆ㒊ࢩࣕࣥࢲࣝ࢞ࣀ㓄ิ㢮ఝࡢࢩ࣮ࢣࣥࢫࢆᣢࡕࠊṈࢀࢆኚ␗ࡉࡏ
ࡿࡇࡼࡾࠊࡑࡢⓎ⌧ຠᯝࡀ࠶ࡿ᳨ウࡋ࡚࠸ࡿ㸦ὠୗ㸧ࠋ
㻌
㻌
−10−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠘ホ౯యไ䠚㻌
䠄◊✲䝥䝻䝆䜵䜽䝖䛾┠ᶆ➼䛻↷䜙䛧䛯⮬ᕫホ౯䛾ᐇ䜔䚸䛭䛾⤖ᯝ䜢◊✲㈝➼䛾㈨※䛾㓄ศ䜈ᫎ䛥䛫䜛䛯
䜑䛾䝹䞊䝹䛾㐺ษ䛺タᐃ䚸䜎䛯䚸ᮏ䝥䝻䝆䜵䜽䝖䛻ಀ䜛㈝⏝ᑐຠᯝ䠄䛛䛡䛯㈝⏝䛻ぢྜ䛖ຠᯝ䛜ぢ䜙䜜䜛䛛䠅䛻
䛴䛔䛶䚸䛹䛾䜘䛖䛻ศᯒ䛧䛶䛔䜛䛛䚹䜎䛯䚸䛭䜜䜙䛻䛴䛔䛶䚸እ㒊䠄➨୕⪅䠅䛻䜘䜛ホ౯䜢ཷ䛡䜛యไ䛜䛷䛝䛶䛔
䜛䛛➼䛻䛴䛔䛶グ㏙䛧䛶䛟䛰䛥䛔䚹䠅㻌
ி㒔⏘ᴗᏛ࡛ࡣࠊᩍဨᴗ⦼ホ౯ไᗘࢆᐇࡉࢀ࡚࠾ࡾࠊࡑࡢ୰࡛ࣉࣟࢪ࢙ࢡࢺ࣓ࣥࣂ࣮ࡢ◊✲㐙
⾜≧ἣࡀᢕᥱ࣭ホ౯ࡉࢀ࡚࠸ࡿࠋ
◊✲㈝ࡘ࠸࡚ࡣࠊᵓㄪ᭩ࡢෆᐜࢆᇶࠊẖᖺࠊᏛ࡛ᐇࡍࡿᴗィ⏬࠾࠸࡚◊✲㈝ࡀỴᐃ
ࡉࢀ࡚࠾ࡾࠊࡘࠊ◊✲ᶵᵓ㐠Ⴀጤဨ࠾࠸࡚ࠊ◊✲ィ⏬ࡘ࠸࡚ᑂ㆟ࢆㅎࡾࠊᐇࡢỴᐃᢎㄆ
ࢆ⾜ࡗ࡚࠸ࡿࠋ
᭱⤊ᖺᗘ࠾࠸࡚ࡣࠊୖグጤဨࡶࠊ ྡࡢእ㒊᭷㆑⪅ホ౯ࢆ౫㢗ࡋࠊᮏࣉࣟࢪ࢙ࢡࢺࡢ
ᡂᯝࡘ࠸࡚ࡢᐈほⓗホ౯ࢆཷࡅࡿணᐃࢆࡋ࡚࠸ࡿࠋ
㻌
㻌
䠘◊✲ᮇ㛫⤊ᚋ䛾ᒎᮃ䠚㻌
䠄ᮏ䝥䝻䝆䜵䜽䝖⤊ᚋ䛻䛚䛡䜛◊✲䛾⥅⥆䛾᭷↓䚸᭷䛾ሙྜ䛿ᚋ䛾◊✲᪉㔪䚸↓䛾ሙྜ䛿ᙜヱ◊✲タ䞉
⨨䞉タഛ䛾ά⏝᪉㔪䜢グ㏙䛧䛶䛟䛰䛥䛔䚹䠅㻌
ᮏ◊✲ࣉࣟࢪ࢙ࢡࢺయ࡛ࡣࠊࡇࢀࡲ࡛グ㏙ࡋ࡚࠸ࡿࡼ࠺ࠊᅜෆእ࠾ࡅࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ
ࡢ᧞⁛ࢆᅗࡿࡇࡀྍ⬟࡞ࡿ◊✲ᡂᯝࢆ࠶ࡆࡿࡇࢆ᭱⤊┠ᶆࡋ࡚࠸ࡿࡀࠊேⓗ⿕ᐖࢆ᭱ᑠ㝈
ᗘᢚ࠼ࠊ㏻ᖖࡢ♫⏕άࡢႠࡳࢆ㸪ࡓ࠼᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢὶ⾜ࡀ࠶ࡗ࡚ࡶࠊ㜼ᐖࡉࢀ࡞࠸
♫ࡢ⤌ࡳసࡾ㈉⊩ࡋࡓ࠸ࠋ
ឤᰁᩘ⌮ࣔࢹࣝࠊࡾࢃࡅᛂᣑᩓࣔࢹࣝᇶ࡙ࡃឤᰁࡢఏ㐣⛬ࡢᩘ⌮ⓗㅖᛶ㉁ࡢゎ᫂㸦⣽
㔝㸧ࠋ ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㸦+1 ᰴ㸧ࡣணࡋேᑐࡍࡿཎ
ᛶࡀ⯡ⓗᙅࡗࡓࡓࡵࠊ㢧ᛶឤᰁࡶὶࢆ༨ࡵࠊ᫂░࡞ゎᯒࡣᅔ㞴࡛࠶ࡗࡓࠋᚋࡉࡽࠊ
᪂ࡋ࠸᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢฟ⌧ࡍࡿྍ⬟ᛶࡣ㧗࠸ࡢ࡛ࠊ༑ศ࡞ഛ࠼ࢆࡋࡓ࠸㸦⣽㔝㸧ࠋ
㻌 ୍᪉ࠊႚ↮ࡼࡾㄏᑟࡉࢀࡓᢚไᛶ⫵⬊࣐ࢡࣟࣇ࣮ࢪࢆࡋ࡚ࡢࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁ
ࡀࡢࡼ࠺࡞ࡿࡢࠊࡲࡓ⻏⻤ࠊ࢟ࣀࢥᢳฟᾮࡼࡾࠊච⣽⬊ࢆࡋࡓ࢘ࣝࢫឤᰁࡀ㜵ᚚฟ
᮶ࡿࡢࡘ࠸࡚ࠊឤᰁᐇ㦂ࢆ⾜࠸ࠊᇶ♏◊✲ࡽᛂ⏝◊✲㐍ࡳࠊච⣽⬊ࢆ⏝࠸࡚ࡢᢠ࢘
ࣝࢫ⸆ࡢ㛤Ⓨࢆ㐍ࡵ࡚࠸ࡃணᐃ࡛࠶ࡿࠋࡲࡓࠊᐇ㦂ⓗᙉẘࡋࡓ +1 ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘
ࣝࢫᰴࢆ⏝࠸࡚ࡢ᳨ウࡶ⾜࠺ணᐃ࡛࠶ࡿ㸦➉ෆ㸧ࠋ㻌
ࡇࢀࡲ࡛ᮍ▱ࡉࢀ࡚ࡁࡓࠊࢩࣝ㓟ྵ᭷⢾㙐ᐩࡴ &' ࡢ⏕≀Ꮫⓗ࡞ᙺࡀゎ᫂ࡉࢀࡿ㸦⚟
㸧ࠋ
08& ศᏊ㛵ࡋ࡚ࡣࠊ⒴⣽⬊ࡢ◊✲ࡽ⣽⬊ෆ࡛ࡢᶵ⬟ศᏊࡋ࡚ࡢ & ᮎࢻ࣓ࣥࡘ࠸࡚ከࡃ
ࡢ◊✲ᡂᯝࡀ࠶ࡾࠊ࢘ࣝࢫࢱࣥࣃࢡ㉁ࡢ┦స⏝࡞ࡀᐃࡉࢀࡿࠋࡇࡢࡼ࠺࡞どⅬࡼࡾ 08&
ཷᐜయ࢘ࣝࢫࡢ⏘⏕ஹ㐍ࡢ㛵ಀࢆࡼࡾ᫂☜ࡍࡿࠋࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫཷᐜయ㛵㐃ࡍࡿ
ሗఏ㐩ศᏊࢆᑐ㇟ࡋ࡚ࠊ᪂ࡓ࡞࢘ࣝࢫឤᰁ㜼ᐖࡋ࡚ࠊVL51$ ࡞ࡢྍ⬟ᛶࢆ᳨ウࡍࡿࠋ
ࡲࡓࠊ⣽⬊⾲㠃ࡢ⢾㙐ࢆㄆ㆑ࡍࡿ࠸ࡃࡘࡢཎᛶ࢘ࣝࢫࡀ▱ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ᡂᯝࢆࡶ
ࡼࡾᗈ⠊࡞◊✲ࢆᒎ㛤ࡍࡿ㸦୰⏣ࠊ⛅⏣㸧ࠋ
㻌 ᙜヱ◊✲࡛ᇵࡗࡓࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ 51$ ࣏࣓࣮ࣜࣛࢮࡢᵓ㐀◊✲ࡣࠊୡ⏺୰ࡀὀ┠ࡋ࡚◊
✲ࢆࡋ࡚࠸ࡿ㡿ᇦ࡛࠶ࡾࠊ๓グ୕✀」ྜయࡢᵓ㐀ゎᯒࡣࠊ᪂ࡓ࡞స⏝ᶵᵓࡢ㜼ᐖタィࡢࡓࡵࡶ
㔜せ࡛࠶ࡿࠋ࡞ࢇ⥅⥆ࢆࡋ࡚࠸ࡁࡓ࠸⪃࠼࡚࠸ࡿ㸦ὠୗࠊ㭯ᮧ㸧ࠋ
㻌
㻌
䠘◊✲ᡂᯝ䛾ḟⓗຠᯝ䠚㻌
䠄◊✲ᡂᯝ䛾ά⏝≧ἣཪ䛿ᚋ䛾ά⏝ィ⏬䠄ᐇ⏝䞉ᴗ䛾ぢ㏻䛧䜔䚸≉チ䛾⏦ㄳ䛜䛒䜜䜀䛭䛾⏦ㄳ≧
ἣ䞉ྲྀᚓ≧ἣ➼䠅䛻䛴䛔䛶䚸グ㏙䛧䛶䛟䛰䛥䛔䚹䠅㻌
⮬↛⛉Ꮫⓗ࡞᪂ᆺࣥࣇ࢚ࣝࣥࢨ㛵ࡍࡿሗࢆᚓ࡚ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ࡢᵓ⠏ࠊ
ࡋ࡚ἲᚊⓗ࡞ほⅬࡽᮏࣉࣟࢪ࢙ࢡࢺᑾຊࡋ࡚࠸ࡿᒾᮏࠊᕝᮏ㸦ᖹᡂ㸰㸱ᖺᗘࡲ࡛㸧୧ᩍᤵࡣࠊ
㫽ྲྀᏛཬࡧᒱ㜧Ꮫ⋇་Ꮫ⛉Ꮫ⏕ᑐࡋ࡚ࠊἲᚊⓗ࡞ഃ㠃ࡽ⋇་Ꮫᩍ⫱ᦠࢃࡗ࡚࠸ࡿࠋ
⣽㔝ᩍᤵࡀᐇࡋ࡚࠸ࡿ◊✲ࡣᇶ♏ⓗ࡞ᩘ⌮ⓗ◊✲࡛࠶ࡾᛂ⏝ᛶࡀᗈ࠸ࠋᅇࡢ◊✲࡛ᚓࡽࢀࡿ
ᩘ⌮ⓗ⤖ᯝࡣ᪂ᆺࣥࣇ࢚ࣝࣥࢨ௨እࡢࡢศ㔝࡛ࡶ⏝࡛ࡁࡿࠋ
−11−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
➉ෆᩍᤵࡣࠊႚ↮ࡀࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁᑐࡋ࡚ࡢ⛬ᗘࡢᙳ㡪ࢆ࠼ࡿࡇࡀศࡿ
ࡇ࡛ࠊឤᰁ㜵Ṇྥࡅࡓྲྀࡾ⤌ࡳࠊච⣽⬊ࢆࡋࡓ࢘ࣝࢫឤᰁ㜵Ṇࡢࡓࡵࡢࠊࡲ࡛
ࡃ␗࡞ࡿほⅬࡽࡢ᪂ࡋ࠸ᢠ࢘ࣝࢫ⸆ࡀ㛤Ⓨࡉࢀࡿ◊✲ᡂᯝࡀᮇᚅฟ᮶ࡿᡤࡲ࡛᮶ࡓ⪃࠼࡚࠸
ࡿࠋࡲࡓࠊᑗ᮶ⓗዲ୰⌫ࢆάᛶࡉࡏᢠ࢘ࣝࢫస⏝ࢆ♧ࡍ≀㉁ࢆྠᐃࡋ⸆ࡋ࡚ࡢ≉チ⏦ㄳ
ฟ᮶ࡿྍ⬟ᛶࡀ⏕ࡌࡓࠋ
⚟ᩍᤵࡣࠊච⣔࠾ࡼࡧ⚄⤒⣔⣽⬊⾲㠃Ⓨ⌧ࡉࢀࠊ$ ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཷᐜయ
࡞ࡿྍ⬟ᛶࡢ㧗࠸ &' ศᏊୖࡢ⢾㙐ᵓ㐀ࢆ᫂ࡽࡍࡿࡇࡼࡾࠊឤᰁᚋ࢘ࣝࢫࡢ㌟ⓗ࡞
ఏᦙࢆ㜵ᚚࡍࡿ᪉ἲ㸦ᣕᢠⓗ࡞㜼ᐖ㸧ࢆ⪃࡛ࡁࡿࠋ
୰⏣ᩍᤵࡽࡢ◊✲ࡽࠊࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫཷᐜయࡢᐇయཬࡧᐟ⣽⬊ෆ࠾ࡅࡿศᏊ
ኚࡢ୍㒊ࡀ᫂ࡽࡉࢀࡓࡇࡼࡾࠊࡼࡾᗈ⠊ᅖࡢ㜼ᐖࡢ㛤Ⓨࡢࣄࣥࢺ࡞ࡿྍ⬟ᛶࡀ⏕ࡌ
ࡓࠋMUC1 ཬࡧ HA ྠ୍ࡢ⢾㙐⤖ྜᛶࢆࡶࡘࢩࢢࣞࢵࢡࣇ࣑࣮ࣜࡘ࠸࡚ࡣࠊୖ㏙ࡋࡓࡼ࠺ࠊ
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᶵᵓࡣࠊ⭷⤖ྜᆺ࣒ࢳ࡛ࣥ࠶ࡿ MUC1 ࡀ㔜せ࡞ാࡁࢆࡍࡿࡇࢆ
♧ࡋࡓࠋMUC1 ୖࡢ⢾㙐ᑐࡍࡿᢠయ࠶ࡿ࠸ࡣ⢾㙐⤖ྜࡍࡿࣞࢡࢳࣥ㸦ࢩࢢࣞࢵࢡࣇ࣑࣮ࣜ㸧
ࡘ࠸࡚ᇶ♏ⓗ◊✲ࢆᒎ㛤ࡋࡓࠋࡍ࡞ࢃࡕࠊMUC1 ࡢࣞࢡࢳࣥࡢ⤖ྜࡀࢩࢢࢼࣝఏ㐩ࢆច㉳ࡍࡿ
ࡇࠊࢩࢢࣞࢵࢡࣇ࣑࣮ࣜࡢ㸯ࡘ࡛࠶ࡿࢩࢢࣞࢵࢡ 9 ࡀᶞ≧⣽⬊ࡢචᢚไࡸάᛶ T ⣽⬊ୖࡢ
ࣉࣟࣄࣅࢳࣥࡢ⤖ྜࡼࡾࠊT ⣽⬊ࡢࢩࢢࢼࣝఏ㐩ࢆᢚไࡍࡿࡇ࡞ࡀ᫂ࡽ࡞ࡗࡓࠋ
ὠୗᩍᤵࡣࠊ௨ୗࡢぢ㏻ࡋࢆ❧࡚࡚࠸ࡿࠋࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ RNA ࡸࢱࣥࣃࢡ㉁ࡢᐟ
⣽⬊ෆ࡛ࡢቑṪࡣࠊPAࠊPB1ࠊPB2ࠊNP ࡽ࡞ࡿ RNA ࣏࣓࣮ࣜࣛࢮ」ྜయࡀᢸࡗ࡚࠸ࡿࠋྛࢧࣈ
ࣘࢽࢵࢺࡢᵝࠎ࡞ࢻ࣓ࣥࡢᵓ㐀ゎᯒࡀⰍࠎ࡞ࢢ࣮ࣝࣉ࡛⾜ࢃࢀ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊPB2
ࡢ C ᮎ➃ഃࡢࢻ࣓ࣥ㸦3/3 㡿ᇦ㸦535-759㸧㸧ࡢᵓ㐀ࢆࡍ࡛᫂ࡽࡋ࡚࠾ࡾࠊࡇࡢ㡿ᇦࡣཎ
ᛶࡢᙉᙅ✀㛫ࡢఏᰁᛶࢆỴᐃࡍࡿ K627 ࢆྵࢇ࡛࠸ࡿ㸦JBC㸦㸰㸮㸮㸷㸧284,6855-6860㸧ࠋࡇࡢ
RNA ࣏࣓࣮ࣜࣛࢮࡢ」ྜయ࠶ࡿ࠸ࡣࣄࢺࡢᅉᏊࡢ⤖ྜࢆ᫂ࡽࡍࡿ࡛ࠊᑗ᮶ⓗࡣࢱ࣑ࣇ
ࣝࠊࣜࣞࣥࢨࡣ␗࡞ࡿ᪂ࡓ࡞ RNA ࣏࣓࣮ࣜࣛࢮࡢ㜼ᐖࢆ⸆ࡍࡿࡘ࡞ࡀࡿࠋ㻌
㻌
䠍䠎㻌 䜻䞊䝽䞊䝗䠄ᙜヱ◊✲ෆᐜ䜢䜘䛟⾲䛧䛶䛔䜛䛸ᛮ䜟䜜䜛䜒䛾䜢䠔㡯┠௨ෆ䛷グ㍕䛧䛶䛟䛰䛥
䛔䚹䠅㻌
䠄䠍䠅㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇㻌 㻌 㻌 㻌 䠄䠎䠅㻌 㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇㻌 㻌 㻌 䠄䠏䠅㻌 ឤᰁᩘ⌮䝰䝕䝹㻌
䠄䠐䠅㻌 ឤᰁ䛸ேᶒ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 䠄䠑䠅㻌 ឤᰁ䛸ἲᨻ⟇㻌 㻌 㻌 㻌 㻌 㻌 䠄䠒䠅㻌 ་ἲ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
䠄䠓䠅㻌 䝺䝉䝥䝍䞊㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 䠄䠔䠅㻌 ච㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌
㻌
䠍䠏㻌 ◊✲Ⓨ⾲䛾≧ἣ䠄◊✲ㄽᩥ➼බ⾲≧ἣ䚹༳ๅ୰䜒ྵ䜐䚹䠅㻌
ୖグ䚸䠍䠍㻔䠐㻕䛻グ㍕䛧䛯◊✲ᡂᯝ䛻ᑐᛂ䛩䜛䜒䛾䛻䛿䠆䜢䛩䛣䛸䚹㻌
㻌
䠘㞧ㄅㄽᩥ䠚㻌
ㄽᩥྡ䚸ⴭ⪅ྡ䚸ᥖ㍕ㄅྡ䚸ᰝㄞ䛾᭷↓䚸ᕳ䚸᭱ึ䛸᭱ᚋ䛾㡫䚸Ⓨ⾲ᖺ䠄すᬺ䠅䛻䛴䛔䛶グධ䛧䛶䛟䛰䛥䛔䠄ᕥグ
䛾ྛ㡯┠䛜⥙⨶䛥䜜䛶䛔䜜䜀䚸㡯┠䛾㡰ᗎ䜢ධ䜜᭰䛘䛶䜒ྍ䠅䚹䜎䛯䚸⌧ᅾ䛛䜙Ⓨ⾲ᖺḟ㡰䛻㐳䜚䚸㏻䛧␒ྕ䜢
䛧䛶䛟䛰䛥䛔䚹㻌
ᵳ䞉㧘᱓䞉ᖖᅧ䞉⸭⏣㻌
*1. Takakuwa, H., Yamashiro, T., M. Q. Le, L. S. Phuong, Ozaki, H., Tsunekuni, R., Usui, T.,
Morimatsu,M., Toioka, Y., Yamaguchi, T., Ito, T., Murase, T., Ono, E., and Otsuki, K.
Molecular epidemiology of avian influenza viruses circulating among healthy poultry farms
in northern Vietnam. Prevent. Vet. Med., 103, 192-200, 2012. ᰝㄞ᭷
*2. Hotta, K., Takakuwa, H., Le, Q. M. T., Phuong, L. S., Murase, T., Ono, E., Ito, T., Otsuki, K.,
Yamashiro, T. 䠖Isolation and characterization of H6N1 and H9N2 avian influenza viruses
from Ducks in Hanoi, Vietnam. Virus Res., 163, 448-453, 2012.㻌 ᰝㄞ᭷
*3. Takakuwa, H., Yamashiro, T., Le, M. Q., Phuong, L. S., Ozaki, H., Tsunekuni, R.,
Usui, T., Ito, H., Morimatsu, M., Tomioka, Y., Yamaguchi, T., Ito, T., Murase, T.,
Ono, E. and Otsuki, K. 㸸Molecular epidemiology of avian influenza viruses
−12−
䠄ᵝᘧ䠍䠅
S0801062
䝥䝻䝆䜵䜽䝖␒ྕ
circulating among healthy poultry flocks in farms in northern Vietnam. Prev. Vet.
Med. 103, 192-200, 2012. ᰝㄞ᭷
*4. Fujimoto, Y., Ito, H., Shivakoti, S., Nakamori, J., Tsunekuni, R., Otsuki, K., and Ito, T.
Avian influenza virus and paramyxovirus isolation from migratory waterfowl and
shorebirds in San-in district of western Japan from 2001 and 2008. J. Vet. Med. Sci., 72,
963-967, 2010. ᰝㄞ᭷㸬
*5. Sakoda Y, Sugar S, Batchluun D, Erdene-Ochir TO, Okamatsu M, Isoda N, Soda K,
Takakuwa H, Tsuda Y, Yamamoto N, Kishida N, Matsuno K, Nakayama E,
Kajihara M, Yokoyama A, Takada A, Sodnomdarjaa R, Kida H.㸸Characterization of
H5N1 highly pathogenic avian influenza virus strains isolated from migratory
waterfowl in Mongolia on the way back from the southern Asia to their northern
territory. Virology, 406, 88-94, 2010. ᰝㄞ᭷
*6. Murata, H., and Otsuki, K. 㸸Swine influenza and cytokines:less of a sorm, more of a breeze.
Vet. J., in press, 2010. ᰝㄞ᭷㸬
*7. Shivakoti, S., Itoh H., Murase, T., Ono, E., Takakuwa, H., Yamashiro, T., Otsuki, K., and
Ito, T. 㸸Development of reverse transcription-loop-mediated isothermal amplification
(RT-LAMP) assay for detection of avian influenza viruses in the field specimens. J. Vet.
Med. Sci., 72, 519-523, 2010. ᰝㄞ᭷㸬
*8. Shivakoti, S., Itoh H., Otsuki, K., and Ito, T. 㸸Characterization of H5N1 highly pathogenic
avian influenza virus isolated from a mountain hawk eagle in Japan. J.
Vet. Med. Sci.,
72, 459-463, 2010. ᰝㄞ᭷㸬
*9. Tsunekuni, R., Ito, H., Kida, H., Otsuki, K., and Ito, T. 㸸Increase in the neuraminidase
activity of a nonpathogenic Newcastle disease virus isolate during passaging in chickens. J.
Vet. Med. Sci., 72, 453-457, 2010. ᰝㄞ᭷㸬
*10. Tsunekuni, R., Ito, H., Otsuki, K., Kida, H., Ito, T. 䠖 Genetic comparisons between
lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants. Virus
Genes. 40, 252-255, 2010. ᰝㄞ᭷㸬
*11. Takakuwa, H., Yamashiro, T., Le, Q. M., Phuong, L. S., Ozaki, H., Tsunekuni, R., Usui, T.,
Ito, H., Yamaguchi, T., Ito, T., Murase, T., Ono, E., Otsuki, K. 㸸Possible circulation of
H5N1 avian influenza viruses in healthy ducks on farms in northern Vietnam. Microbiol.
Immunol ., 54, 58-62, 2010. ᰝㄞ᭷㸬
*12. Takakuwa, H., Maruoka, T., Hata, T., Miyazawa, M., Hata, T., Toshimori, T., and Otsuki,
K. 㸸Development of a new disinfectant with very strong anti-influenza-viral activity -a
preliminary report. Environ. Health Prev. Med., 15, 121-123. 2010. ᰝㄞ᭷㸬
*13. 㧘᱓ᘯᶞ㸪ᖖᅧⰋኴ㸪⸭⏣ῄண㸪୰ᮧಖ⣖㸪ୖ⊛ኵ㸪ᵳබ୍.㸸㸱✀㢮ࡢᚤ㤶ࡃࢇᾮࡢᢠ
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫຠᯝ㸬㜵⳦㜵㰄㸪37, 879-882, 2009㸬ᰝㄞ᭷㸬
*14. 㧘᱓ᘯᶞ㸪ᖖᅧⰋኴ㸪ᵳබ୍㸬㸸H1 ளᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᑐࡍࡿᾘẘ⸆ࡢຠᯝ㸬
ᐙ␆⾨⏕Ꮫ㞧ㄅ㸪35, 57-58, 2009. ᰝㄞ᭷㸬
㻌
୰⏣䞉⛅⏣㻌
*15.Yurugi H, Tanida S, Ishida A, Akita K, Toda M, Inoue M, Nakada H. 㸸Expression of
prohibitins on the surface of activated T cells. Biochem Biophys Res Commun., 420:
−13−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
275-280,2012. ᰝㄞ᭷䠊
*16.Akita K, Yoshida S, Ikehara Y, Shirakawa S, Toda M, Inoue M, Kitawaki J, Nakanishi H,
Narimatsu H, Nakada H. 㸸Different Levels of Sialyl-Tn Antigen Expressed on MUC16 in
Patients With Endometriosis and Ovarian Cancer. Int J Gynecol Cancer., 22:
531-538,2012. ᰝㄞ᭷䠊
*17.Yuasa N, Ogawa H, Koizumi T, Tsukamoto K, Matsumoto-Takasaki A, Asanuma H,
Nakada H, Fujita-Yamaguchi Y. 㸸 Construction and expression of anti-Tn-antigen-specific
single chain antibody genes from hybridoma producing MLS128 monoclonal antibody. J
Biochem., 151: 371-381,2012.㻌 ᰝㄞ᭷䠊
*18.Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, Tsuchida A,
Matsubara T, Hori T, Okajima T, Furukawa K, Urano T, Furukawa. 㸸pp-GalNAc-T13
induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn
antigen. Biochem Biophys Res Commun., 419: 7-13,2012.㻌 ᰝㄞ᭷䠊
*19.Subedi GP, Satoh T, Hanashima S, Ikeda A, Nakada H, Sato R, Mizuno M, Yuasa N,
Fujita-Yamaguchi Y, Yamaguchi. 䠖 Overproduction of anti-Tn antibody MLS128
single-chain Fv fragment in Escherichia coli cytoplasm using a novel pCold-PDI vector.
Protein Expr Purif., 82: 197-204,2012.㻌 ᰝㄞ᭷䠊
*20.Matsumoto-Takasaki A, Hanashima S, Aoki A, Yuasa N, Ogawa H, Sato R,
Kawakami
H,Mizuno M, Nakada H, Yamaguchi Y, Fujita-Yamaguchi Y. 䠖 Surface plasmon resonance
and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three
consecutive Tn-antigen clusters. Biochem. J., 151: 273-282䠈2012.㻌 ᰝㄞ᭷䠊
*21.Koizumi T, Matsumoto-Takasaki A, Nakada H, Nakata M, Fujita-Yamaguchi Y.
Preparation of asialo-agalacto-glycophorin A for screening of anti-Tn antibodies. Biosci
Trends., 4: 308-311,2011. ᰝㄞ᭷䠊
*22.Hamaguchi M, Kawahito Y, Ishino H, Takeuchi N, Tokunaga D, Hojo T, Yamamoto A,
Kadoya M, Seno T, Kohno M, Nakada H. 㸸Mucin from rheumatoid arthritis synovial fluid
enhances interleukin-6 production by human peripheral blood mononuclear cells. Hum
Immunol., 72: 241-248,2011. ᰝㄞ᭷䠊
*23.Ohta, M., Ishida, A., Toda, M., Akita, K., Inoue, M., Yamashita, K., Watanabe, M., Murata,
T., Usui, T., Nakada, H.㸸Immunomodulation of monocyte-derived dendritic cells through
ligation of tumor-produced mucins to Siglec-9. Biochem. Biophys. Res. Commun.,402:
663-669,2010. ᰝㄞ᭷䠊
*24. Ishino, H., Kawamoto, Y., Hamaguchi, M., Takeuchi, N., Tokunaga, D., Hojo, T., Wada, M.,
Yamamoto, A., Kadoya, M., Tsubouchi, Y., Kohno, M., Nakada, H.㸸Expression of Tn and
sialyl Tn antigens in synovial tissues in rheumatoid arthritis. Clin. Exp. Rheumatol., 28:
246-249, 2010. ᰝㄞ᭷㸬
*25.Morita, N., Yajima, Y., Asanuma, H., Nakada, H., Fujita-Yamaguchi, Y.㸸Inhibition of cancer
cell growth by anti-Tn monoclonal antibody MLS128. BioScience Trends, 3(1): 32-37,
2009. ᰝㄞ᭷㸬
*26.Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adach, T., Tsubata,
T., Nakada, H.㸸Ligation of tumor-produced mucins to CD22 dramatically impairs splenic
marginal zone B cells. Biochem. J., 417: 673-683, 2009. [Feb 14, 2009]. ᰝㄞ᭷㸬
*27.Ishida, A., Ohta, M., Toda, M., Murata, T., Usui, T., Akita, K., Inoue, M., Nakada, H.
Mucin-induced apoptosis of monocyte-derived dendritic cells during maturation.
Proteomics, 8: 3342-3349, 2008 [August, 2008]. ᰝㄞ᭷㸬
*28.Toda, M., Akita, K., Inoue, M., Taketani, S., Nakada, H.㸸Down-modulation of B cell signal
transduction by ligation of mucins to CD22. Biochem. Biophys. Res. Commun., 372:
45-50, 2008. [July 18, 2008] ᰝㄞ᭷㸬
㻌
−14−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
⣽㔝㻌
*29.⣽㔝㞝୕ࠊᮤ⪷ᯘࠊᮧ⏣ᐂಇ㸬
㸸ධ㐣⛬⌧ࢀࡿ㐍⾜Ἴゎࡘ࠸࡚㸬ி㒔Ꮫᩘ⌮ゎᯒ◊✲ᡤ
ㅮ✲㘓㸬1663 ᕳࠊp65-71㸬ᖹᡂ 21 ᖺ㸬ᰝㄞ↓㸬
㻌
ᕝᮏ㻌
*30.ᕝᮏဴ㑻㸬
㸸ឤᰁᑐ⟇࠾ࡅࡿධࡢ᰿ᣐ࠾ࡼࡧゎ㔘㸬ಖᖌࢪ࣮ࣕࢼࣝ. 67 ᕳࠊp970㸫973㸬
ᖹᡂ 23 ᖺ㸬ᰝㄞ↓㸬
*31.ᕝᮏဴ㑻㸬㸸᪂ᆺࣥࣇ࢚ࣝࣥࢨ⢭⚄⛉㝔࣭ฮタ࡞ࡢ㛢㙐ฎ㐝㸬⏘ἲᏛ㸬45 ᕳࠊ
p1-17㸬ᖹᡂ 23 ᖺ㸬ᰝㄞ↓㸬
*32.ᕝᮏဴ㑻㸬㸸⋇་⒪࠾ࡅࡿࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺ㸬⏘ἲᏛ㸬44 ᕳࠊp1-14㸬ᖹᡂ 22
ᖺ. ᰝㄞ↓㸬
*33.ᕝᮏဴ㑻㸬㸸᪂ᆺࣥࣇ࢚ࣝࣥࢨἲᨻ⟇㸬⏘ἲᏛ㸬44 ᕳࠊp1-14㸬ᖹᡂ 22 ᖺ㸬ᰝㄞ↓㸬
*34.ᕝᮏဴ㑻㸬㸸᪂ᆺࣥࣇ࢚ࣝࣥࢨἲ㸬⏘ἲᏛ㸬43 ᕳࠊp1-19㸬ᖹᡂ 21 ᖺ㸬ᰝㄞ↓㸬
*35.ᕝᮏဴ㑻㸬㸸᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐࡍࡿᏛࡢྲྀࡾ⤌ࡳ㸬⏘ἲᏛ㸬42 ᕳࠊp1-12㸬ᖹᡂ 20
ᖺ㸬ᰝㄞ↓㸬
*36.ᕝᮏဴ㑻㸬
㸸᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ேᶒ㸬⏘ἲᏛ㸬41 ᕳࠊp66-80㸬ᖹᡂ 20 ᖺ㸬ᰝㄞ↓㸬
㻌
⚟㻌
*37. S.Fukui and M. Kawahara.䠖Rat CD24 is one of major poly-N-acetyl- lactosamine-carrying
glycoproteins in PC12 cells and rat bone marrow, but not in PC12D cells and rat brain.
Glycoconjugate J. 26, 818-819, 2009. ᰝㄞ᭷㸬
㻌
℩ᑿ㻌
*38. Terada M., Ohnishi, C., Ueno, N., Shimizu, A., Kanai, M., Seo, M. 䠖Enhanced expression of
fibroblast growth factor receptor 3 in human skin cancer cells. The Open Circulation &
Vascular J. 2, 30-36, 2009. ᰝㄞ᭷㸬㻌
㻌
➉ෆ㻌
*39. Miyahara, E.,Nishie, M., Takumi, S., Miyanohara, H., Nishi, J., Yoshiie, K., Oda, H.,
Takeuchi, M., Komatsu, M., Aoyama, K., Horiuchi, M., Takeuchi, T..㸸Environmental
mutagens may be implicated in emergence of drug-resistant microorganisms. FEMS
Microbiology Letters, 2011 Apr;317(2):109-116, ᰝㄞ᭷
*40. Koichiro Yoshimoto, Tsunao Kishida, Hiroshi Nakano, Masahiro Matsui, Masaharu
Shin-Ya, Taketoshi Shimada, Shigeru Nakai, Jiro Imanishi, Minoru Takeuchi, Yasuo Hisa
and Osam Mazda. 㸸Interleukin-28B acts synergistically with cisplatin to suppress the
growth of head and neck squamous cell carcinoma. Journal of Immunotherapy, 2011
Mar;34(2):139-48, ᰝㄞ᭷
*41. Fukuda M, Kobayashi K, Hirono Y, Miyagawa M, Ishida T, Ejiogu EC, Sawai M, Pinkerton
KE, Takeuchi M.㸸Jungle honey enhances immune function and antitumor activity. Evid
Based Complement Alternat Med., 2011:1-7,2011, ᰝㄞ᭷
*42.▼⏣ႛ⿱ ➉ෆᐇ㸸ႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࢆࡋࡓᢠཎ≉␗ⓗ࠾ࡼࡧ㠀≉␗ⓗ࡞ࣜࣥ
ࣃ⌫ቑṪᛂཬࡰࡍᙳ㡪 ி㒔⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ ➨ 40 ྕ,71-108,2011. ᖹᡂ
23 ᖺ 3 ᭶Ⓨ⾜ ᰝㄞ᭷
*43. Mayuko Miyagawa, Miki Fukuda, Yuriko Hirono, Ayaka Kawazoe, Eri Shigeyoshi,Masaaki
Sakura, Toru Takeuchi, Osamu Mazda, Kent E. Pinkerton and Minoru Takeuchi,㸸Effect
of Jungle honey on chemotactic activity of neutrophils. Journal of ApiProduct and
ApiMedical Science. 2(4):149-154,2010, ᰝㄞ᭷
*44. ᘅ㔝⏤㔛Ꮚ ➉ෆᐇ㸸ࢱࣂࢥὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ㹂㹌㸿ᦆയࡢㄏᑟ࣏ࢺ࣮
ࢩࢫࡢᢚไ ி㒔⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ ➨ 39 ྕ,63-93,2010. ᖹᡂ 22 ᖺ 3 ᭶Ⓨ⾜
ᰝㄞ᭷
−15−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
*45.Ishida T, Hirono Y, Yoshikawa K, Hutei Y, Miyagawa M, Sakaguchi I, Pinkerton KE,
Takeuchi M.㸸Inhibition of immunological function mediated DNA damage of alveolar
macrophages caused by cigarette smoke in mice. Inhal Toxicol. Dec;21(14):1229-35, 2009,
ᰝㄞ᭷
*46.Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M,
Takeuchi T. 㸸Dehydroepiandrosterone increased oxidative stress in a human cell line
during differentiation. Free Radic Res. Oct;43(10):922-31.2009, ᰝㄞ᭷
*47.Ishida T, Pinkerton KE, Takeuchi M.㸸Alveolar macrophage from cigarette smoke-exposed
mice inhibits B lymphocyte proliferation stimulated with LPS. Respiration. 77(1):91-5.
2009, ᰝㄞ᭷
*48.⚟⏣⨾ᶞ ᐑᕝ┿⏤Ꮚ ➉ෆ ᐇ㸸ࢪࣕࣥࢢࣝࣁࢽ࣮ࡼࡿචᶵ⬟ࡢᙳ㡪ᢠ⭘⒆స⏝
⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ ➨ 38 ྕ ᖹᡂ 21 ᖺ 3 ᭶Ⓨ⾜ 95-118, ᰝㄞ᭷
*49. Bei Yu, Urmila P. Kodavanti, Minoru Takeuchi,㸸Hanspeter Witschi and Kent E.
Pinkerton.
Acute Tobacco Smoke-Induced Airways Inflammation in Spontaneously Hypertensive
Rats. Inhalation toxicology ,20:623-633.2008, ᰝㄞ᭷
㻌
ὠୗ䚸㭯ᮧ㻌
*50. Oda M, Takahashi M, Tsuge H, Nagahama M, Sakurai J. 㸸Role of side-edge site of
sphingomyelinase from Bacillus cereus. Biochem Biophys Res Commun. ( 2012)
ᰝㄞ᭷ࠋ
*51. Imagawa T, Tsurumura T, Sugimoto Y, Aki K, Ishidoh K, Kuramitsu S, Tsuge H.
Structural basis of the free reduced flavin generation by flavin reductase from Thermus
thermophilus HB8. J Biol Chem. 286: 44078-85. (2011) ᰝㄞ᭷.
*52. Ohtomo H, Konuma T, Utsunomiya H, Tsuge H, Ikeguchi M. 㸸Structure and stability of
Gyuba, ș-lactoglobulin chimera. Protein Sci. 20:1867-75. (2011) ᰝㄞ᭷.
*53. Yoshida T, Tsuge H, Konno H, Hisabori T, Sugano Y.㸸The catalytic mechanism of
dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid
residue. FEBS J. 278:2387-94. (2011) ᰝㄞ᭷.
*54. Inaka K, Takahashi S, Aritake K, Tsurumura T, Furubayashi N, Yan B, Hirota E, Sano S,
Sato M, Kobayashi T, Yoshimura Y, Tanaka H, Urade Y. 㸸High-Quality Protein Crystal
Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in Microgravity. Cryst Growth
Des. 11:2107-2111.(2011) ᰝㄞ᭷.
*55. Watanabe T, Tsuge H, Imagawa T, Kise D, Hirano K, Beppu M, Takahashi A, Yamaguchi
K, Fujiki H, Suganuma M.㸸Nucleolin as cell surface receptor for tumor necrosis
factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori. J Cancer Res
Clin Oncol. 136:911-21. (2010) ᰝㄞ᭷.
㻌
䠘ᅗ᭩䠚㻌
ᅗ᭩ྡ䚸ⴭ⪅ྡ䚸ฟ∧♫ྡ䚸⥲䝨䞊䝆ᩘ䚸Ⓨ⾜ᖺ䠄すᬺ䠅䛻䛴䛔䛶グධ䛧䛶䛟䛰䛥䛔䠄ᕥグ䛾㡯┠䛜⥙⨶䛥䜜䛶
䛔䜜䜀䚸㡯┠䛾㡰ᗎ䜢ධ䜜᭰䛘䛶䜒ྍ䠅䚹䜎䛯䚸⌧ᅾ䛛䜙Ⓨ⾲ᖺḟ㡰䛻㐳䜚䚸㏻䛧␒ྕ䜢䛧䛶䛟䛰䛥䛔䚹㻌
ᵳ䞉㧘᱓䞉ᖖᅧ䞉⸭⏣㻌
㸨>@ ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿ࣃࣥࢹ࣑ࢵࢡ㸬་⸆ࢪ࣮ࣕࢼࣝ♫㸬㜰㸬
㸬
㸨>@ ᵳබ୍ࠊ㧘᱓ᘯᶞࠊୖ⍞ỤࠊᖖᅧⰋኴࠊ⸭⏣ῄண㸬㉥⾑⌫จ㞟⣲ኚ␗ࢆຍ࠼ࡓH5N1
ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀங㢮ࡢឤᰁᛶࢆ⋓ᚓࡋࡓ⏬ᮇⓗ࡞Ἑᒸ⩏⿱ᩍᤵࡽࡢ
ㄽᩥࡘ࠸࡚࣮ࢹ࣮ࣗࣝࣘࢫࡀᠱᛕࡉࢀࡓ࣮㸬ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ,
No. 11, 31-39, 2012.
㸨>@ ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨⓎ⏕࣭ឤᰁᣑࡢྍ⬟ᛶ㸬࣌ࢫࢺࢥࣥࢺ࣮ࣟࣝ, No. 158, 4-9,
−16−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
2011.
㸨>@ ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡢᇶ♏ᅜෆእࡢⓎ⏕≧ἣࡘ࠸࡚㸬᪥ᮏᐙ⚺Ꮫㄅ48㸦⛅
Ꮨྕ㸧, 1-4, 2011
㸨>@ ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⏕ែ㸬ᮾᾏ␆⏘Ꮫሗ㸪22㸪2-6, 2011㸬
㸨>@ ᵳබ୍㸬Ⓨ⏕ࡀṆࡲࡽ࡞࠸㫽ࣥࣇ࢚ࣝࣥࢨ㸬SEEDer, No. 5, 78-82, 2011.
㸨>@ ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄண㸬2010ᖺᬌ⛅ࡽᅜෆ࡛ከⓎࡋࡓ㫽
ࣥࣇ࢚ࣝࣥࢨ㸬ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 10, 45-61, 2011.
㸨>@ ᵳබ୍㸬ㅮᗙ ὀ┠ࡉࢀࡿឤᰁไᚚᑐ⟇㸵 㫽ࣥࣇ࢚ࣝࣥࢨ㸬㜵⳦㜵㰄,39(6)㸪
375-387, 2011㸬
㸨>@ ᵳබ୍㸬ㅮᗙ ࡃࡽࡋᚤ⏕≀㸳 ࣐ࢫࢡ㸬㜵⳦㜵㰄㸪39(3), 175-183, 2011.
㸨>@ᵳබ୍㸬᪥ᮏྛᆅ࡛Ⓨ⏕ࡋ࡚࠸ࡿ㧗ཎᛶ㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ἣ㸬㭜ࡢ◊✲, 86(3)㸪
15̽20, 2011㸬
㸨>@ᵳබ୍㸬㧗ཎᛶ㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ἣࡇࢀࡽࡢഛ࠼㸬㎰ᴗ⤒῭㸪77(2), 79-88,
2011㸬
㸨>@ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄண㸬≉㞟㸭᪂ᆺࣥࣇ࢚ࣝࣥࢨ AH1N1
ࡢὶ⾜ࢆࡾ㏉ࡗ࡚㸬ࢺࣜࣥࣇ࢚ࣝࣥࢨࡢὶ⾜≧ἣ㸬⮫ᗋ◊✲㸪87(12), 1718-1723, 2010.
㸨>@ᵳබ୍㸬≉㞟ࣥࣇ࢚ࣝࣥࢨ㸬ࣈࢱ࣭ࢺࣜࣥࣇ࢚ࣝࣥࢨࡢ⌧≧㸬ᑠඣෆ⛉㸪42(9)㸪2010.
㸨>@ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄணࠊ୰ᮧಖ⣖ࠊᯇୗ⨾⣖ࠊᒣྡⱥ᫂㸬
ࣥࣇ࢚ࣝࣥࢨᑐ⟇ࠊ≉㧗ᶵ⬟ຍ࣐ࢫࢡࡢ᭷⏝ᛶ. ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ,
No. 9, 103-117, 2010.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ᪂ᆺ࢘ࣝࢫࡢୡ⏺ⓗὶ⾜㸦ࣃࣥࢹ࣑ࢵࢡ㸧㸬㜵⳦㜵㰄㸪38(5),
297-307, 2010.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ̿ࢪ࠾ࡅࡿH5N1ளᆺ࢘ࣝࢫࡢ⏕ែ—㸬⮫ᗋ
ᚤ⏕≀㸪37(2), 99-104, 2010.
㸨>@ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿 2010㸸㸱㸬ࣈࢱࣥࣇ࢚ࣝࣥࢨࡢṔྐࡣ㸽
㸲㸬ࣃࣥࢹ࣑ࢵࢡ㫽ࣥࣇ࢚ࣝࣥࢨࡢᚋࡢ᥎⛣ࡣ㸽ࡢ㸰㡯┠ࢆᇳ➹ࠊ㕥ᮌ ᏹࠊᯇᮏ
୕⦅ࠊ་⸆ࢪ࣮ࣕࢼࣝ♫ࠊ㜰㸬2010.
㸨>@ᵳබ୍ ㇜ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㉳ᅉࡍࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢⓎ⏕ὶ⾜㸬㭜ࡢ◊
✲, 84(7), 36-39, 2009.
㸨>@ᵳබ୍㸬ឡ▱┴࡛Ⓨ⏕ࡋࡓ㫽ࣥࣇ࢚ࣝࣥࢨ㸬㭜ࡢ◊✲, 84(5), 20-23, 2009.
㸨>@ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢṇయ—࢘ࣝࢫฟ⌧ࡢ⤒⦋ࡑࡢ≉ᛶ—㸬Ꮫ㸪64(10),
12-17, 2009.
㸨>@ᵳබ୍㸬ࢪࡢ㫽ࣥࣇ࢚ࣝࣥࢨ—Ⓨ⏕≧ἣ㸬㭜◊✲ሗ㸪45㸦ቑหྕ㸧㸪17Ѹ21㸪
2009㸬
㸨>@ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊ୰ᮧಖ⣖ࠊୖ⍞Ụ㸬2009ᖺฟ⌧ࡋࡓ࠸ࢃ
ࡺࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ. ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 8, 75-82, 2009.
㸨>@ᵳබ୍㸬ᕳ㢌ゝ 2008ᖺ4᭶㡑ᅜ࡛Ⓨ⏕ࡋࡓ㫽ࣥࣇ࢚ࣝࣥࢨ㸬ࣥࣇ࢚ࣝࣥࢨ,
10(1), 9-10, 2009.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸲㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇㸬㏆
௦ᾘ㜵, No. 577, 92-94, 2009.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸱㸬㫽ࣥࣇ࢚ࣝࣥࢨࡘ࠸࡚㸬
㏆௦ᾘ㜵, No. 576, 94-95, 2009.
−17−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
㸨>@ᵳබ୍㸬࢘ࣝࢫࡀࢧࢡࢵࢃࡿᮏ㸸┘ಟࠊᘅ῭ᇽࠊᮾி㸬2009㸬
㸨>@ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿 2009㸸㸳㸬ᐙ⚺࣌ࢫࢺࡑࡢṔྐ—࠸ࡘࡇࡢ
ᝈࡀࣥࣇ࢚ࣝࣥࢨࢃࡗࡓࡢ㸽ࡢ㡯┠ࢆᇳ➹ࠊ㕥ᮌ ᏹࠊᯇᮏ୕⦅ࠊ་⸆ࢪ࣮ࣕ
ࢼࣝ♫ࠊ㜰㸬2009㸬
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸰㸬㫽ࣥࣇ࢚ࣝࣥࢨࡘ࠸࡚㸬
㏆௦ᾘ㜵, No. 575, 90-91, 2008.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 1㸬㫽ࣥࣇ࢚ࣝࣥࢨࡘ࠸࡚㸬
㏆௦ᾘ㜵, No. 574, 69-71, 2008.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ̿ࡇࡢഛ࠼࡚㸬㭜ࡢ◊✲, 83(11), 22-25, 2008.
㸨>@ᵳබ୍㸬㸲᭶㉳ࡁࡓᾏ㐨࣭ᮾᆅᇦࡢ㫽ࣥࣇ࢚ࣝࣥࢨ㸬㭜ࡢ◊✲, 83(7), 18-21,
2008.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ẁ㝵—㫽ࡽࣄࢺࠊࣄࢺࡽࣄࢺࡢఏࡣࡇࡲ࡛㐍ࢇ
࡛࠸ࡿ㸬᭶หಖᅋ㐃㸪No. 982, 25-30, 2008.
㸨>@ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ୰㞞ᬗ ᭱ࡶ༴㝤࡞እ᮶ᛶࡢ㫽⏤᮶ே⋇ඹ㏻ឤᰁ—㫽
ࣥࣇ࢚ࣝࣥࢨ̿. ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 7, 161-176, 2008.
㸨>@ᵳබ୍㸬ே⋇ඹ㏻ឤᰁࡋ࡚ࡢ㫽ࣥࣇ࢚ࣝࣥࢨ㸬㫽ྲྀ་Ꮫ㞧ㄅ, 34(1), 3-6, 2008.
㸨>@ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡣ㸬ᡂே⏕ά⩦័, 38(11), 1244-1250 , 2008.
㸨>@ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨ ࠶࡞ࡓࡢࣃࣥࢹ࣑ࢵࢡᑐ⟇ࡣ㛫㐪ࡗ࡚࠸ࡿ㸽㸟㸸┘ಟࠊ㏆
௦ᾘ㜵♫ࠊᮾி㸬2008.
㸨>@ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨࡽᐙ᪘ࢆᏲࡿ18ࡢ᪉ἲ㸸⦅ⴭࠊ㟷ฟ∧ࠊᮾி㸬2008.
୰⏣㻌
㸨>@M.Toda and H.Nakada; Immunosuppressive effect of carcinoma-produced mucins on B
cell function. pp 226-238. 2010, FCAA.
㸨>@H. Nakada; Biological significance of mucins produced by epithelial cancer cells.
Experimental Glycoscience (eds. N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T.
Kawasaki and S. Hase).
pp238-245.
2008, Springer.
㸨>@୰⏣ ༤㸬ᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࡢ⏕≀Ꮫⓗព⩏㸬㑇ఏᏊ་ᏛࠊMOOK11ࠕ⮫ᗋ⢾㙐ࣂ
࣐࣮࣮࢜࢝ࡢ㛤ⓎѸ⢾㙐ᶵ⬟ࡢゎ᫂ࡑࡢᛂ⏝ࠖ
㸸pp.148-154ࠊ2008㸬࣓ࢹ࣭࢝ࣝࢻ㸬
㸨>@୰ ⏣ ༤ 㸬 ࣒ ࢳ ࣥ ࢆ ࡋ ࡓ ⭘ ⒆ ⣽ ⬊ ࡢ ቑ Ṫ ࣭ 㐍 ᒎ 㸬 ⺮ ⓑ ᰾ 㓟 㓝 ⣲ Vol.53 No.12 㸬
pp.1604-1610ࠊ2008㸬ඹ❧ฟ∧㸬
㻌
䠘ᏛⓎ⾲䠚㻌
Ꮫྡ䚸Ⓨ⾲⪅ྡ䚸Ⓨ⾲ᶆ㢟ྡ䚸㛤ദᆅ䚸Ⓨ⾲ᖺ᭶䠄すᬺ䠅䛻䛴䛔䛶グධ䛧䛶䛟䛰䛥䛔䠄ᕥグ䛾㡯┠䛜⥙⨶䛥䜜
䛶䛔䜜䜀䚸㡯┠䛾㡰ᗎ䜢ධ䜜᭰䛘䛶䜒ྍ䠅䚹䜎䛯䚸⌧ᅾ䛛䜙Ⓨ⾲ᖺḟ㡰䛻㐳䜚䚸㏻䛧␒ྕ䜢䛧䛶䛟䛰䛥䛔䚹㻌
ᵳ䞉㧘᱓䞉ᖖᅧ㻌
㸨>@ Koichi Otsuki. Outbreaks of avian influenza in Japan –An outbreak of H5N1 HPAI in Kyoto
prefecture and management done by local government. BIT’s 1st World Congress of Virus and
Infections-2010. Theme: Voice of Virologits, Busan, South Korea, 31st July-3rd August 2010.㻌
㸨>@ Hiroki Takakuwa, Toshihiro Ito, Toshiyuki Murase, Tetsu Yamashiro, Etsuro Ono and
Koichi Otsuki. Molecular epidemiology of avian influenza in northern Vietnam. Workshop
on the Influenza Research of J-GRID: The Inaugural Meeting of the Influenza Consortium,
Tokyo, 16th July 2010.
−18−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
㸨>@ Hiroki Takakuwa, Tetsu Yamashiro, Mai Quynh Le, Lien Song Phuong, Ryota Tsunekuni,
Tatsufumi Usui, Hiroichi Ozaki, Hiroshi Ito, Tsuyoshi Yamaguchi, Toshihiro Ito, Koichi
Otsuki, Toshiyuki Murase, and Etsuro Ono. Molecular epidemiology of avian influenza
viruses circulating among healthy poultry bred in farms in northern Vietnam. 4th Annual
Meeting EPIZONE, St Malo, France, 7th – 10th June 2010.
㸨>@ Hiroki Takakuwa, Tetsu Yamashiro, Le Quynh Mai, Phuong Son Lien, Etsuro Ono, Ryota
Tsunekuni, Tatsufumi Usui, Hiroichi Ozaki, Hiroshi Itoh, Takeshi Yamaguchi, Toshihiro Ito,
Koichi Otsuki, and Toshiyuki Murase, Infection of H5N1 avian influenza viruses in healthy
ducks on farms in northern Vietnam. International Joint Forum on Infectious Diseases.
Bangkok, Thailand, 16th-17th September 2009.
㸨>@ Koichi Otsuki, Etsuro Ono, Hiroki Takakuwa, Toshiyuki Murase, Toshihiro Ito, Hiroshi Itoh,
Le Ouynh Mai, Phuong Son Lien, Kouichi Morita, Tetsu Yamashiro. Epizootiology of Avian
Influenza. The International Symposium on Environmental Change, Pathogens, and Human
Linkages, Research Institute for Humanity and Nature in Kyoto, 11th-14th June 2008.
㸨>@ Koichi Otsuki, Etsuro Ono, Hiroki Takakuwa, Toshiyuki Murase, Toshihiro Ito, Le Ouynh
Mai, Phuong Son Lien, Kouichi Morita, Tetsu Yamashiro. Surveillance of Avian Influenza
Virus in Vietnam. The Asian Research Forum on Emerging and Reemerging Infections,
2008, Osaka 28th-29th January 2008.
㻌
୰⏣䞉⛅⏣㻌
㸨>@ H.Nakada, Y.Mori, S.Tanida K.Akita A.Ishida M.Toda M.Inoue.
with Galectin-3
Interaction of MUC1
enhances the proliferation of epithelial tumor cells. 26 International
Carbohydrate Symposium. Madrid,Spain [2012.7.22-27]
㸨>@ ୰⏣ ༤ࠊඵ௦ṇࠊ⃝⏣㕲ࠊᖹᕝᘯ⪷㸬࢞ࣞࢡࢳࣥ-3 ࡢ MUC1 ࡢ⤖ྜక࠺⒴⣽⬊
ቑṪಁ㐍స⏝㸬➨ ᅇ᪥ᮏࡀࢇ㌿⛣Ꮫࠊᗈᓥ[2012.7.12-13]
㸨>@ ⛅⏣⸅ࠊụཎㆡࠊ୰す㏿ኵࠊᡂᯇஂࠊ୰⏣༤08&ୖࡢV7QᢠཎࡢⓎ⌧ᇶ࡙ࡃᏊᐑ
ෆ⭷༸ᕢ⒴ࡢ㆑ู1('2⢾㙐ࣉࣟࢪ࢙ࢡࢺᡂᯝሗ࿌ࠊᮾி[2011.11.16-17]
㸨>@G.P. Subedi, T. Satoh, S. Hanashima, A. Ikeda, H. Nakada, R. Sato, M.Mizuno, N.
Yuasa, Y. Fujita-Yamaguchi, Y. Amaguchi. NMR analysis of an anti-carbohydrate
antibody single-chain Fv fragment toward elucidation of the multivalent recognition
mechanism. The International Symposium on Nuclear Magnetic Resonance.
Yokohama,Japan [2011.11.15-18]
㸨>@୰⏣ ༤࣒ࢳࣥࣇ࣑࣮ࣜ㸹⭘⒆࣐࣮࣮࢝ࡢⓎ⌧ࠊᵓ㐀࠾ࡼࡧ⭘⒆ᝏᛶࡢ㛵㐃ᛶ➨
ᅇ⢾㙐⏘ᴗᢏ⾡ࣇ࢛࣮࣒ࣛࠊᶓ [2011.10.5]
㸨>@ᯇᮏᗣஅࠊ❶㟷ࠊᮧ⣖ࠊ⛅⏣⸅ࠊ୰⏣༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥᚭஓࠊྂᕝᆂ
Ꮚࠊᾆ㔝ࠊྂᕝ㗰୍SS*DO1$F7ࡣ WULPHULF7Qᢠཎࢆྜᡂࡍࡿࡇࡼࡾ⒴㌿⛣
ࢆஹ㐍ࡉࡏࡿ㸸ᶆⓗࢱࣥࣃࢡ㉁ࡢྠᐃ➨ ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊྡྂᒇ[2011.10.3-5]
㸨>@⛅⏣⸅ࠊụཎㆡࠊୖ⍞Ụࠊ୰す㏿ኵࠊᡂᯇஂࠊ୰⏣༤Ꮚᐑෆ⭷࠾ࡼࡧ༸ᕢ⒴ᝈ
⪅࠾ࡅࡿ &$ࢥࢱࣥࣃࢡ㉁ୖࡢࢩࣜࣝ 7Qᢠཎࣞ࣋ࣝࡢ⮫ᗋⓗホ౯➨ ᅇ᪥
ᮏ⏕Ꮫࠊி㒔[2011.9.21-24]
㸨>@➲㔝᪸ኴࠊᡞ⏣᐀㇏ࠊᒾྖࠊ☄ịὈᕷࠊᮧ⏣⮧ࠊ୰⏣༤ேᕤࢢࣛࢥ࣏࣐࣮ࣜ
ࡼࡿ⒴㌿⛣ᢚไ࠾ࡼࡧᢠ⅖స⏝➨ ᅇ᪥ᮏ⏕Ꮫࠊி㒔[2011.9.21-24]
−19−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
㸨>@ᯇᮏᗣஅࠊ❶㟷ࠊᮧ⣖ࠊ⛅⏣⸅ࠊ୰⏣༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥᚭஓࠊྂᕝᆂ
Ꮚࠊᾆ㔝ࠊྂᕝ㗰୍SS*DO1$F7ࡼࡿ⒴㌿⛣ࡢศᏊ࣓࢝ࢽࢬ࣒➨ ᅇ᪥ᮏ⏕
Ꮫࠊி㒔[2011.9.21-24]
㸨>@᳃ຬఃࠊ⛅⏣⸅ࠊ㇂⏣࿘ᖹࠊ▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤ࣄࢺ⭠⒴⏤
᮶⣽⬊࠾ࡅࡿ 08& *DOHFWLQࡢ┦స⏝ࡼࡿቑṪಁ㐍ຠᯝ➨ ᅇ᪥ᮏ⏕Ꮫ
ࠊி㒔[2011.9.21-24]
㸨>@㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤08& *DOHFWLQࡢ⤖ྜࡑࡢ⏕
≀Ꮫⓗព⩏➨ ᅇ᪥ᮏ⏕Ꮫࠊி㒔[2011.9.21-24]
㸨>@H. Nakada, S. Tanida, K. Akita, M. Toda, M. Inoue. MUC1 mediated signaling through
ligation with Siglec-9. The 21st International Symposium on Glycoconjugates. Vienna,
Austria
[2011.8.21-26]
㸨>@K. Akita, S. Yoshida, Y. Ikehara, S. Shirakawa, M. Toda, M. Inoue, J.Kitawaki, H.
Nakanishi, H. Narimatsu, H. Nakada. Clinical evaluation of sialyl-Tn antigen level on
CA125 core protein inpatients with endometriosis and ovarian cancer. The 21st
International Symposium on
lycoconjugates. Vienna,Austria
[2011.8.21-26]
㸨>@ᯇᮏᗣஅࠊ❶㟷ࠊᮧ⣖ࠊ⛅⏣⸅ࠊ୰⏣༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥᚭஓࠊྂᕝᆂ
Ꮚࠊᾆ㔝ࠊྂᕝ㗰୍SS*DO1$F7ࡣWULPHULF7Qᢠཎࢆᙧᡂࡋ⒴㌿⛣ࢆஹ㐍ࡉࡏࡿ
ᶆⓗࢱࣥࣃࢡ㉁ࡢྠᐃ➨ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊ㛗ᒸ[2011.7.11-13]
㸨>@୰⏣༤ࠊ㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏㸬ෆᅾᛶࣞࢡࢳࣥࡢ⤖ྜక࠺08&ࢆࡋࡓࢩࢢ
ࢼࣝఏ㐩㸬➨ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊ㛗ᒸ[2011.7.11-13]
㸨>@ୖ⍞Ụࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊఀ⸨ኖၨࠊᵳබ୍ࠊ୰⏣༤㸬ࢽ࣡ࢺࣜẼ㐨
ୖࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⤖ྜ⺮ⓑ㉁ࡢ᳨⣴㸬➨33ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨83ᅇ
᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
㸨>@▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣ ⸅ࠊୖ⍞Ụࠊ୰⏣ ༤ࢩࢢࣞࢵࢡ㸱ࡼࡿ 7ROOOLNH
UHFHSWRU㸲ࢩࢢࢼࣝఏ㐩ࡢᢚไ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫ
ྜྠࠊ⚄ᡞ[2010.12.7-10]
㸨>@ ᡞ⏣᐀㇏ࠊᒣୗ⥅ྐࠊΏ㑓ᫀᙪࠊ▼⏣᭷ᕼᏊࠊ⛅⏣ ⸅ࠊୖ⍞Ụࠊᮧ⏣⮧ࠊ☄ịὈᕷࠊ
୰⏣ ༤㸬Immunosuppressive effect of mucin on splenic marginal zone B cells in
tumor-bearing state.➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ
⚄ᡞ[2010.12.7-10]
㸨>@ ㇂⏣࿘ᖹࠊ⛅⏣ ⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣ ༤6LJOHFࡢ⤖ྜక࠺08&ࢆ
ࡋࡓሗఏ㐩➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄
ᡞ[2010.12.7-10]
㸨>@ ቑ⏣┤ஓࠊࢨ࣒ࣜࣀ࣮࣐ࣝࢨࠊỌ♸ᐅࠊ▮ᓥ⏤⣖Ꮚࠊ୰⏣ ༤ࠊᒣཱྀ㸦⸨⏣㸧㝧
Ꮚᢠ 7Qᢠయ 0/6ࡢࣄࢺ⤖⭠ࡀࢇ⣽⬊ +7ᑐࡍࡿቑṪᢚไస⏝➨ 33 ᅇ᪥ᮏศ
Ꮚ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
㸨>@ ᒾྖࠊᒸಟᖹࠊᡞ⏣᐀㇏ࠊ☄ịὈᕷࠊᮧ⏣⮧ࠊ୰⏣ ༤◲㓟⢾ྵ᭷ே
ᕤ࣒ࢳࣥ 3ࢭࣞࢡࢳࣥࡢ┦స⏝ࡢゎᯒ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥
ᮏ⏕Ꮫྜྠࠊ⚄ᡞ[2010.12.7-10]
㸨>@ G.P. Subedi, T.Satoh, S. Hanashima, A.Ikeda, H.Nakada, R. Sato, M. Mizuno, N.Yuasa,
Y. Fujita-Yamaguchi, and Y.Yamaguchi. Establishment of overproduction procedure
for anti-Tn antigen MLS128 single-chain Fv fragment toward the structural studies.➨
−20−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ[2010.12.7-10]
㸨>@୰⏣ ༤㸬ච⣽⬊ࡢ࣒ࢳࣥ⤖ྜศᏊࢆ⫼ᬒࡍࡿචไᚚࡢ㛤Ⓨ㏆␥ࣂ࢜ࣥࢲ
ࢫࢺ࣮ࣜ⯆㆟ࠊ㜰[2010.12] 㸨>@ୖ⍞Ụࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊఀ⸨ኖၨࠊᵳබ୍ࠊ୰⏣༤㸬ࢽ࣡ࢺࣜẼ㐨
ୖࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⤖ྜ⺮ⓑ㉁ࡢ᳨⣴㸬➨ ᅇ࢘ࣝࢫᏛᏛ⾡⥲ࠊᚨᓥ
[2010.11.7-9]
㸨>@୰⏣༤ࠊୖ⍞Ụ㸬ࢩࢢࣞࢵࢡ 9 ࡢ┦స⏝ࡼࡿ MUC1 ࢆࡋࡓࢩࢢࢼࣝఏ㐩㸬MUC1
mediated signaling through interaction with Siglec-9.
➨ 69 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊ
p.81ࠊ2010.9.22ࠊ㜰 [2010.9.22-24]
㸨>@T. Murata, T. Hattori, Y. Honda, M. Toda, E. Y. Park, T. Usui, and H.Nakada.
Chemoenzymatic synthesis of artificial mucins carrying sialylated O-linked glycans
with a polylactosamine extension and interactions with CD22/siglec-2. The 25th
International Carbohydrate Symposium. Chiba,Japan [2010.8.1-6]
㸨>@Hiroshi Nakada.
Signal transduction through MUC1-Siglec 9 interaction.
7th
International Symposium on Glycosyltransferases, GlycoT 2010, p.54-55, 2010.8.1
Tokyo, Japan [2010.7.31-8.1]
㸨>@ྜྷ⏣࿘ᖹࠊ⛅⏣⸅ࠊᑠᇼ☻ዉ⨾ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬࢞ࣞࢡࢳࣥ-3 ࡼࡿ
MUC-1 ࢆ ࡋ ࡓ ࢞ ࣥ ⣽ ⬊ ቑ Ṫ ಁ 㐍 స ⏝ 㸬 Galectin-3 promotes cell proliferation of
MUC1-expressing cancer cells.
➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp336ࠊ2009.10.24ࠊ⚄ᡞ
[2009.10.21-24]
㸨>@㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬Siglec-9 ࡢ MUC1 ࡢ⤖ྜక࠺ሗ
ఏ㐩ࢆ⣽⬊ᐦᗘࡼࡿ┦㐪㸬MUC1 mediated signaling through ligation with Siglec-9
and its alteration due to different cell density.
➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp336ࠊ
2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
㸨>@ᡞ⏣᐀㇏ࠊᒣୗ⥅ྐࠊΏ㑓ᫀᙪࠊᮌ⫕ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊᮧ⏣⮧ࠊ☄ịὈᕷࠊ୰⏣
༤ 㸬 Immunosuppressive effect of mucin on splenic marginal zone B cells in
tumor-bearing state.
➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp336ࠊ2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
㸨>@▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 3 ࠾ࡼࡧ 9 ࡼࡿ Toll-like
receptor-4 ࢩࢢࢼࣝఏ㐩ࡢᢚไ㸬Regulation of Toll-like receptor-4 mediated signaling by
Siglec-3 and 9. ➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp344ࠊ2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
㸨>@୰⏣༤ࠊୖ⍞Ụ㸬⭘⒆⏘⏕࣒ࢳࣥࡢࢩࢢࣞࢵࢡ 2 ࡢ⤖ྜࢆࡋࡓ⭁⮚࣐࣮ࢪࢼࣝࢰ࣮
ࣥ B ⣽ ⬊ ࡢ ᦆ യ 㸬 Impairment of splenic marginal zone B cells by ligation of
tumor-produced mucins to Siglec 2.
➨ 68 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊp.278ࠊ2009.10.2ࠊᶓ
[2009.10.1-3]
㸨>@㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 9 ࡢ⤖ྜక࠺ MUC1 ࢆ
ࡋࡓሗఏ㐩㸬Signal transduction through MUC1 with the binding of Siglec-9.
➨ 29
ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.160ࠊ2009.9.11㸪㧗ᒣ [2009.9.9-11]
㸨>@▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 3 ࡼࡿ Toll-like receptor-4
ࢩ ࢢ ࢼ ࣝ ఏ 㐩 ࡢ ᢚ ไ 㸬 Siglec-3 regulates signal transduction mediated by Toll-like
receptor-4.
➨ 29 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.165ࠊ2009.9.11㸪㧗ᒣ [2009.9.9-11]
㸨>@ᮌ⫕ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ⛅⏣⸅ࠊᮧ⏣⮧ࠊ☄ịὈᕷࠊ୰⏣༤㸬Siglec-E ࡢ◲㓟⢾
㙐ࡢ⤖ྜ㸬Binding of Siglec-E to sulfated oligosaccharide.
−21−
➨ 29 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊ
䠄ᵝᘧ䠍䠅
S0801062
䝥䝻䝆䜵䜽䝖␒ྕ
p.168ࠊ2009.9.11ࠊ㧗ᒣ [2009.9.9-11]
㸨>@୰⏣༤㸬⒴ᚤᑠ⎔ቃ࠾ࡅࡿ࣒ࢳࣥࢆࡋࡓචᢚไ⭘⒆ቑṪ㸬➨ 18 ᅇ᪥ᮏࡀࢇ㌿⛣Ꮫ
Ꮫ⾡㞟ࠊp.14ࠊ2009.7.23ࠊ᪫ᕝ [2009.7.23-24]ㅮ₇
㸨>@Hiroshi Nakada.
Mucin-mediated immune regulation and tumor progression.
Clinical and Translational Research on Cancer: Blycomics Applications, p.62-63,
2009.3.26. Mie, Japan [2009.3.24-27]
㸨>@㇂⏣࿘ᖹࠊ⸨ᮏ⚈ᙲࠊኴ⏣㯞Ꮚࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 9
ࡢ⤖ྜక࠺ MUC1 ࢆࡋࡓሗఏ㐩㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕
Ꮫྜྠࠊp161ࠊ2008.12.9ࠊ⚄ᡞ [2008.12.9-12]
㸨>@▼⏣ளᕼᏊࠊኴ⏣㯞Ꮚࠊᮌ⫕ࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊᮧ⏣⮧ࠊ☄ịὈᕷࠊ୰
⏣༤㸬༢⌫㸭ᶞ≧⣽⬊ࡢࢩࢢࣞࢵࢡ 3 ཬࡧ 9 ࡢ࣒ࢳࣥࡢ⤖ྜ⏕≀Ꮫⓗព⩏㸬➨ 31 ᅇ᪥
ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊp161ࠊ 2008.12.9ࠊ⚄ᡞ
[2008.12.9-12]
㸨>@ᑠᒣⰾỤࠊྜྷᐩὈኸࠊᲷᒃ⪷୍ࠊᡞ⏣᐀㇏ࠊ୰⏣༤ࠊᒸᒣᐿࠊᑠᰩె௦Ꮚ㸬࣊ࣃࣛࣥ◲㓟⬺
6 ◲㓟㓝⣲ࠊSulfsࠊࡢ⒴㌿⛣ᢚไస⏝㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕
Ꮫྜྠࠊp169ࠊ2008.12.9ࠊ⚄ᡞ [2008.12.9-12]
㸨>@Kazuhiro Tsukamoto, Ayano Matsumoto-Takasaki, Noriyuki Yuasa, Keiko Sakai,
Yukiko
Yamaji,
Hiroshi
Nakada,
Hideki
Asanuma,
Yoko
Fujita-Yamaguchi.
Construction and characterization of single-chain variable fragments (scFvs) from
hybridoma producing anti-tn antigen monoclonal antibody, MLS128.
➨ 31 ᅇ᪥ᮏศᏊ
⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊp172ࠊ2008.12.9ࠊ⚄ᡞ [2008.12.9-12]
㸨>@⛅⏣⸅ࠊ℈ཱྀ┿ⱥࠊ୰ᔱ❶㞝ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊᕝே㇏ࠊ୰⏣༤㸬ྍ⁐ᆺࢫ࢝࣋ࣥࢪࣕ
࣮ཷᐜయࢆ⏝࠸ࡓ࣐࢘ࢫ㛵⠇⅖ᑐࡍࡿᢠ⅖ຠᯝ㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81
ᅇ᪥ᮏ⏕Ꮫྜྠࠊp161ࠊ2008.12.10ࠊ⚄ᡞ [2008.12.9-12]
㸨>@୰⏣༤㸬࣒ࢳࣥୖⓎ⌧ࡉࢀࡿ⒴㛵㐃⢾㙐ᢠཎ㸬Tumor-associated carbohydrate antigens
expressed on mucins.
➨ 67 ᅇ ᪥ ᮏ ⒴ Ꮫ Ꮫ ⾡ ⥲ ࠊ p.478 ࠊ 2008.10.30 ࠊ ྡ ྂ ᒇ
[2008.10.28-30]
㸨>@ୖ⍞Ụࠊ ୰⏣༤㸬ୖ ⓶ᛶ⒴ࡢᢸ ⒴≧ែ࠾ ࡅࡿ࣒ࢳࣥ ࡢ⏕≀Ꮫⓗ ព⩏㸬Biological
significance of mucins in epithelial tumor-bearing state.
➨ 67 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊ
p.265ࠊ2008.10.29ࠊྡྂᒇ [2008.10.28-30]
㸨>@ሯᮏᾈࠊ㓇ᜨᏊࠊᮌᓮᏳ⣖Ꮚࠊὸᚨ⾜ࠊ㧗ᓮ㸦ᯇᮏ㸧⥤ࠊὸ⚽ᶞࠊబ⸨⋹Ꮚࠊᕝ
ୖᏹᏊࠊỈ㔝┿┒ࠊ㧗ᰗ῟ࠊ୰⏣༤ࠊᒣཱྀ㸦⸨⏣㸧㝧Ꮚ㸬Tn ᢠཎ≉␗ⓗ༢ࢡ࣮ࣟࣥᢠయ
MLS128 83D4 ⏤᮶༢㙐ᢠయࡢㄪ〇≉␗ᛶゎᯒ㸬➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.xxvࠊ
2008.8.19ࠊࡘࡃࡤ [2008.8.18-20]
㸨>@⛅⏣⸅ࠊ୰ᔱ❶㞝ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬⓶യ⒵࠾ࡅࡿ࣐ࢡࣟࣇ࣮ࢪࢡ
ࣛࢫ A ࢫ࢝࣋ࣥࢪ࣮ࣕཷᐜయࡢ⏕≀Ꮫⓗព⩏㸬➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.xxࠊ2008.8.20ࠊ
ࡘࡃࡤ [2008.8.18-20]
㸨>@ᮧ⏣⮧ࠊᡞ⏣᐀㇏ࠊ☄ịὈᕷࠊ୰⏣༤㸬◲㓟⢾ྵ᭷ேᕤ࣒ࢳ࣐ࣥࢡࣟࣇ࣮ࢪࢫ࢝࣋
ࣥࢪࣕࣜࢭࣉࢱ࣮ࡢ┦స⏝ゎᯒ㸬➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.xxࠊ2008.8.19ࠊࡘࡃࡤ
[2008.8.18-20]
㸨>@୰⏣༤ࠊᡞ⏣᐀㇏ࠊ⸨ᮏ⚈ᙲࠊ㇂⏣࿘ᖹࠊ▼⏣᭷ᕼᏊࠊኴ⏣㯞Ꮚࠊ⛅⏣⸅ࠊୖ⍞Ụ㸬ᢸ
⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࢆࡋࡓᵝࠎ࡞⏕≀Ꮫⓗᶵ⬟㸬➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.xiࠊ
−22−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
2008.8.18ࠊࡘࡃࡤ [2008.8-18-20]
㸨>@୰⏣༤㸬ᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࡢ⏕≀Ꮫⓗᶵ⬟㸬ᖹᡂ 20 ᖺᗘᮾᾏᏛ⏕⌮Ꮫ◊✲ᡤ◊✲
࣭⢾㙐ᶵ⬟◊✲ࠊp.Xࠊ2008.5.22ࠊᒸᓮ [2008.5.22-23]
㻌
⣽㔝㻌
㸨>@⣽㔝㞝୕㸬ධၥ㢟㐍⾜Ἴゎ㸬᪥ᮏᩘ⌮Ꮫࠊி㒔ࠊᖹᡂ 20 ᖺ 8 ᭶㸬
ᕝᮏ
㸨>@ᕝᮏဴ㑻㸬ឤᰁἲ࠾ࡅࡿேᶒࡢ㓄៖㸬ᖹᡂ㸰㸲ᖺᗘ᪥ᮏ♫་Ꮫ⥲㸬2012.7.16ࠊ
㜰࣭㧗ᵳᕷ
⚟㻌
㸨>@S.Fukui and M. Kawahara. Rat CD24 is one of major
poly-N-acetyllactosamine-carrying glycoproteins in PC12 cells and rat bone marrow, but
not in PC12D cells and rat brain. ➨ 20 ᅇᅜ㝿」ྜ⢾㉁ࢩ࣏ࣥࢪ࣒࢘ ࢧࣥࣇࣥࠊࣉ࢚
ࣝࢺࣜࢥ ᖹᡂ 21 ᖺ 11 ᭶㸬
℩ᑿ㻌
㸨>@ྜྷ⏣ளభ⨾㸪℩ᑿ⨾㕥㸬VEGF-A ࡢ Neuropilin ࢆࡋࡓ⒴⣽⬊ࡢቑṪಁ㐍. ➨ 14 ᅇ᪥ᮏࡀ
ࢇศᏊᶆⓗ⒪ᏛᏛ⾡㞟㸬ᮾி㸬ᖹᡂ 22 ᖺ㸵᭶㸬
㸨>@ྜྷ⏣ளభ⨾㸪ᑎ⏣ᇶ๛㸪ΎỈ⏨㸪℩ᑿ⨾㕥㸬⾑⟶ෆ⓶⣽⬊ቑṪᅉᏊ(VEGF-A)ࡣࠊ⒴⣽⬊
⮬㌟ࡢቑṪ࣭ࢥࣟࢽ࣮ᙧᡂࢆಁ㐍ࡍࡿ㸬➨ 57 ᅇ᪥ᮏ⏕Ꮫ㏆␥ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22
ᖺ 5 ᭶㸬
㸨>@ᔱᮁ㸪ᒸᮏἋ▮㤶㸪ᑎ⏣ᇶ๛㸪᳃ᕝຬ㈗㸪ΎỈ⏨㸪బ⸨┤Ꮚ㸪⥴᪉㸪℩ᑿ⨾㕥㸬࢝ࣝ
࣐ࣥೃ⩌ཎᅉ㑇ఏᏊ⏘≀ Anosmin-1 ࡣ FGFR1 άᛶࡼࡿᡂ㛗㗹ᙧᡂࢆಁ㐍ࡍࡿ㸬
➨ 57 ᅇ᪥ᮏ⏕Ꮫ㏆␥ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
㸨>@ᒸᮏἋ▮㤶㸪᳃ᕝຬ㈗㸪ྜྷᘅ⨾㔛㸪ᔱᮁ㸪ᑎ⏣ᇶ๛㸪ΎỈ⏨㸪బ⸨┤Ꮚ㸪⥴᪉㸪℩ᑿ
⨾㕥㸬FGFR1 acid box 㡿ᇦࡣ⚄⤒✺㉳ఙ㛗㔜せ࡞ᙺࢆᯝࡓࡍ㸬➨ 57 ᅇ᪥ᮏ⏕Ꮫ
㏆␥ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
㸨>@ᑎ⏣ᇶ๛㸪ᒸᮏἋ▮㤶㸪すຊ㸪ୖ㔝ಙὒ㸪ΎỈ⏨㸪㔠㝣⾜㸪℩ᑿ⨾㕥㸬ᝏᛶᡥᖹୖ⓶
⒴⣽⬊࠾ࡅࡿ⥺⥔ⱆ⣽⬊ቑṪᅉᏊཷᐜయ 3 ࡢⓎ⌧ஹ㐍㸬➨ 82 ᅇ᪥ᮏ⏕Ꮫ㸬⚄ᡞ㸬
ᖹᡂ 21 ᖺ 10 ᭶㸬
➉ෆ㻌
㸨>@ᐑᕝ┿⏤Ꮚࠊᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊᘅ㔝⏤㔛Ꮚࠊబṇ᫂ࠊ➉ෆࠊࢣࣥࢺ࣭ࣆ࣮ࣥ࢝ࢺ
ࣥࠊ➉ෆᐇ㸬࢞ࣜࢡࢫⲖ⇕Ỉᢳฟᾮࡼࡿዲ୰⌫ࡢ㉮άᛶࡑࡢ᭷ຠᡂศ㸬➨ 60 ᅇ᪥
ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
㸨>@ᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊబṇ᫂ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊ➉ෆᐇ㸬LPS ⤒㰯ᢞࡼࡿ
⫵⅖ࡢㄏᑟዲ୰⌫ᶵ⬟ࡘ࠸࡚㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬ᮾி㸬ᖹ
ᡂ 22 ᖺ 11 ᭶㸬
㸨>@ᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊబṇ᫂ࠊᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊ✄㈡ࡍࡳࢀࠊᯇ⏣ಟࠊ㛗ⱌᏊࠊ
➉ෆࠊࢣࣥࢺ࣭ࣆ࣮ࣥ࢝ࢺࣥࠊ➉ෆᐇ㸬ࢱࣂࢥὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA
ᦆയࡑࡢಟ㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
−23−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
㸨>@㔜ྜྷ⍛㔛ࠊᕝῧᙬ㤶ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊబṇ᫂ࠊ➉ෆᐇ㸬⻏⻤ࡼࡿᢠయ⏘⏕ᶵ
⬟ࡢᙳ㡪㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
㸨>@Mayuko Miyagawa, Ayaka Kawazoe, Eri Shigeyoshi, Yuriko Hirono, Toru Takeuchi,
K.E. Pinkerton and Minoru Takeuchi. Induction of neutrophils in LL/2 tumor bearing
mice. ➨ 69 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲㸬㜰㸬ᖹᡂ 22 ᖺ 9 ᭶㸬
㸨>@M. Miyagawa, A. Kawazoe, E. Shigeyoshi, Y. Hirono, M. Sakura, T. Takeuchi, K.E.
Pinkerton, M. Takeuchi. HOT WATER EXTRACT OF AGARICUS BLAZEI MURILL
(ABM) PREVENTS THE AGEING PROCESS BY ACTIVATION OF NEUTROPHIL
FUNCTIONS. THE 1st INTERNATIONAL CONGRESS ON CONTROVERSIES IN
LONGEVITY, HEALTH AND AGING㸬ࣂࣝࢭࣟࢼ㸬ᖹᡂ 22 ᖺ 6 ᭶㸬
㸨>@Y. Hirono, S. Inoue, M. Miyagawa, T. Ishida, M. Sakura, S. Inaga, O. Mazda, S. Nagai, T.
M. Takeuchi Cigarette Smoke Induces DNA Damage but not Apoptosis in Alveolar
Macrophages. American Thoracic society (ATS) ATS 2010 International Conference. ࢽ
࣮࣮ࣗ࢜ࣜࣥࢬ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
㸨>@G. Walter Canonica, Carlos E. Baena-Cagnani. e Minoru Takeuchi MEDIMOND
INTERNATIONAL PROCEEDINGS. World Allergy Congress WAC, 132 pages, 2009.
㸨>@M. Miyagawa, S. Inoue, Y. Hirono, T. Ishida, M. Sakura, T. Takeuchi, Y. Hoshishima,
K.E. Pinkerton, M. Takeuchi. FFECT OF HOT WATER EXTRACT FROM AGARICUS
BLAZEI MURILL ON IMMUNE FUNCTIONS. XXI World Allergy Congress (WAC). ࣈ
࢚ࣀࢫࣞࢫ㸬ᖹᡂ 21 ᖺ 12 ᭶㸬
㸨>@Shinichi Inoue, Yuriko Hirono, Mayuko Miyagawa, Takahiro Ishida, Osamu Mazda,
Sonoko Nagai, Toru Takeuchi, K.E. Pinkerton, M Takeuchi. Effect of Side-stream
Tobacco Smoke on DNA Damage in Alveolar Macrophage. ➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ⾡⥲㸬
ᶓ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
㸨>@Mayuko Miyagawa, Shinichi Inoue, Hirono Yuriko, Takahiro Ishida, Masaaki Sakura,
Toru Takeuchi, Yuichi Hoshishima, Kent E. Pinkerton, Minoru Takeuchi. The
mechanism of anti-tumor activity in induced immune cells by hot water extract from
Agaricus blazei Murill.➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ⾡⥲㸬ᶓ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
㸨>@Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Sumire Inaga,
Tomonori Naguro, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E. Pinkerton,
Minoru Takeuchi. Repair of DNA Damage in Alveolar Macrophages Induced by
Cigarette Smoke Exposure. ➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ⾡⥲㸬ᶓ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
㸨>@M Takeuch, Y Hirono, M Miyagawa, S Inoue, T Ishida, S Nagai, K E Pinkerton. The
mechanism of inhibition of immune function in Alveolar Macrophage (AM) by smoking.
The 49th Annual Meeting of The Japanese Respiratory Society. ᮾி㸬ᖹᡂ 21 ᖺ 6 ᭶㸬
㸨>@A. Ross, K.E. Pinkerton, M. Takeuchi. Neonatal Murine Sensitivity to Influenza
Infection Is Enhanced by Perinatal Exposure to Environmental Tobacco Smoke.
American Thoracic society (ATS) ATS 2008 International Conference. ࢧࣥࢹ࢚ࢦ㸬ᖹ
ᡂ 21 ᖺ 5 ᭶㸬
㸨>@M. Takeuchi, Y. Hirono, M. Miyagawa, S. Inoue, T. Ishida, S. Inaga, T. Naguro, T.
Takeuchi, S. Nagai, K.E. Pinkerton. Inhibition of immunological functions in alveolar
macrophages (AM) related with DNA damage by cigarette tobacco smoke exposure.
−24−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
American Thoracic society (ATS) ATS 2008 International Conference. ࢧࣥࢹ࢚ࢦ㸬ᖹ
ᡂ 21 ᖺ 5 ᭶㸬
㸨>@ୖៅ୍ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊ▼⏣ႛ⿱ࠊᯇ⏣ಟࠊ㛗ⱌᏊࠊ➉ෆࠊK.E.Pinkertonࠊ
➉ෆᐇ㸬ὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA ᦆയࡢᙳ㡪㸬➨ 38 ᅇ ᪥ᮏචᏛ⥲
࣭Ꮫ⾡㞟㸬ி㒔㸬ᖹᡂ 20 ᖺ 12 ᭶㸬
㸨>@HIRONO Yuriko, INOUE Shinichi, MIYAGAWA Mayuko, MAZDA Osamu, NAGAI
Sonoko, TAKEUCHI Toru, PINKERTON K.E, TAKEUCHI Minoru. Cigarette smoke
induced DNA damage, but not apoptosis of alveolar macrophages. ➨ 38 ᅇ ᪥ᮏචᏛ
⥲࣭Ꮫ⾡㞟㸬ி㒔㸬ᖹᡂ 20 ᖺ 12 ᭶㸬
㸨>@Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Takahiro Ishida, Osamu Mazda, Toru
Takeuchi, K.E. Pinkerton, Minoru Takeuchi. Effect of hot water extract from Agaricus
blazei Murill on chemotaxis of nuetrophils. ➨ 38 ᅇ ᪥ᮏචᏛ⥲࣭Ꮫ⾡㞟㸬ி㒔㸬
ᖹᡂ 20 ᖺ 12 ᭶㸬
㸨>@Hirono Yuriko, Inoue Shinichi, Miyagawa Mayuko, Asada Hidetsugu, Mazda Osamu,
Nagai Sonoko, Takeuchi Toru, Pinkerton K.E, Takeuchi Minoru. igarette smoke induces
DNA damage and inhibition of apoptosis in alveolar macrophages. ➨ 67 ᅇ ᪥ᮏ⒴Ꮫ
Ꮫ⾡⥲㸬ྡྂᒇ㸬ᖹᡂ 20 ᖺ 10 ᭶㸬
㸨>@Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Hidetsugu Asada, Osamu Mazda,
Toru Takeuchi, K.E. Pinkerton, Minoru Takeuchi. Effect of hot water extract from
Agaricus blazei Murill on immue functions and anti-tumor activity. ➨ 67 ᅇ ᪥ᮏ⒴Ꮫ
Ꮫ⾡⥲㸬ྡྂᒇ㸬ᖹᡂ 20 ᖺ 10 ᭶㸬
㸨>@➉ෆᐇࠊ▼⏣ႛ⿱ࠊᘅ㔝⏤㔛Ꮚࠊᑠᯘᝅࠊᐑᕝ┿⏤Ꮚࠊୖៅ୍ࠊ➉ෆࠊKent E. Pinkerton㸬
ࢱࣂࢥὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪᶵ⬟ࡢᢚไᶵᵓࡘ࠸࡚㸬➨ 146 ᅇ ᪥ᮏ⋇་Ꮫ
Ꮫ⾡㞟㸬ᐑᓮ㸬ᖹᡂ 20 ᖺ 9 ᭶㸬
㸨>@ᘅ㔝⏤㔛Ꮚࠊᑠᯘᝅࠊ⚟⏣⨾ᶞࠊᐑᕝ┿⏤Ꮚࠊᯇ⏣ಟࠊὸ⏣⚽ᇶࠊ㛗ⱌᏊࠊ➉ෆࠊ
K.E. Pinkertonࠊ➉ෆᐇ㸬ႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA ᦆയࡢㄏᑟ࣏ࢺ࣮ࢩ
ࢫࡢᢚไ㸬➨ 48 ᅇ ᪥ᮏ྾ჾᏛᏛ⾡ㅮ₇㸬⚄ᡞ㸬ᖹᡂ 20 ᖺ 6 ᭶㸬
㸨>@M. Takeuchi, K. Kobayashi, Y. Hirono, S. Nagai, K.E. Pinkerton. Cigarette Smoke
Inhibits Antibody Production-Associated with Alveolar Macrophage. American Thoracic
society (ATS) ATS 2008 International Conference. ࢺࣟࣥࢺ㸬ᖹᡂ 20 ᖺ 5 ᭶㸬
㻌
ὠୗ䚸㭯ᮧ㻌
㸨>@⛅ᾈࠊ㭯ᮧಇࠊ␊ᒣࠊⴱཎ㝯ࠊὠୗⱥ᫂㸸ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫRNA࣏࣓࣮ࣜࣛࢮ
PB2ࡢX⥺⤖ᬗᵓ㐀ゎᯒ
⏕Ꮫ 2012.12
㸨>@㭯ᮧಇࠊὠୗⱥ᫂㸸ࣔࣀࢩࣝࢢࣜࢭ࣮ࣟࣝࣜࣃ࣮ࢮࡢ㔞యᙧᡂࡣࡑࡢᶵ⬟㔜せ?
⏕Ꮫ 2012.12
㸨>@Hideaki Tsuge, Toshiharu Tsurumura, Masataka Oda, Masahiro Nagahama 㸸Actin
Recognition and ADP-ribosylation of C. perfringens iota-toxin The 11th Awaji
International Forum on Infection and Immunity 2012.9.13
㸨>@㭯ᮧಇࠊὠᏲ⪨Ⰻࠊ⛅ᾈࠊὠୗⱥ᫂㸸ࢡࢳࣥ ADP ࣜ࣎ࢩࣝᛂక࠺㓝⣲ࡢᵓ㐀
ኚࢱࣥࣃࢡ㉁⛉Ꮫ 2012.6
㸨>@ὠୗⱥ᫂㸸 ADP ࣜ࣎ࢩࣝẘ⣲ᵓ㐀◊✲ࡢ᭱๓⥺ ࢩ࣏ࣥࢪ࣒࢘ࠕᝈ⒪⏝࠸ࡿኳ↛
−25−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
᭷ᶵྜ≀ࡢ⏕ྜᡂ㑇ఏᏊࡢໟᣓⓗ⌮ゎࠖᚨᓥᩥ⌮Ꮫࠊ2011.12.22
㸨>@ὠୗⱥ᫂㸸ࢡࢳࣥ ADP ࣜ࣎ࢩࣝࡢᵓ㐀ᇶ┙ ࢩ࣏ࣥࢪ࣒࢘ࠕADP ࣜ࣎ࢩࣝࡼࡿ
ࢩࢢࢼࣝఏ㐩ไᚚࠖ⏕Ꮫࠊி㒔ᅜ㝿㤋ࠊ2011.9.21
㸨>@ὠୗⱥ᫂㸸ឤᰁᅉᏊࣄࢺࢱࣥࣃࢡ㉁ࡢ┦స⏝ࢆぢࡿ㸸X ⥺ࡢࠊ㜰ᛴࢢࣛࣥࢻࣅࣝ
26㝵ࠊ2011.9.10
㸨>@ Tsurumura T., Tsuge H.㸸Crystal structure of Ia-Actin complex with novel ligand ᅜ㝿
⤖ᬗᏛ Madrid, 2011.8.25-26
㸨>@Tsurumura T., Tsuge H.㸸Structural basis for the Helicobacter pylori-carcinogenic
TNF-alpha-inducing protein ᅜ㝿⤖ᬗᏛ Madrid, 2011.8.25-26
㸨>@㭯ᮧಇࠊὠୗⱥ᫂㸸ADPࣜ࣎ࢩࣝẘ⣲ࡼࡿࢡࢳࣥㄆ㆑ࡢ≉␗ᛶゎᯒ ᪥ᮏ⺮ⓑ㉁
⛉Ꮫ, 㜰ᗓ྿⏣ᕷࠊ2011.6.7-9
㸨>@ᕝ㈗ோࠊὠୗⱥ᫂㸸㧗ᗘዲ⇕⳦ HB8 ⏤᮶ࡢࣇࣛࣅࣥ㑏ඖ㓝⣲ࡢᵓ㐀ᶵ⬟ゎᯒ ࣅࢱ࣑
ࣥ B ◊✲ጤဨ ➨ 422 ᅇ◊✲༠㆟ ி㒔ᕷࠊ2010.11.27
㸨>@ὠୗⱥ᫂㸸ࣔࣀ ADP ࣜ࣎ࢩࣝẘ⣲ࡑࡢᶆⓗࢱࣥࣃࢡ㉁ࢡࢳࣥࡢ」ྜయࡢ X ⥺⤖
ᬗᵓ㐀ゎᯒ㸸ᅜ❧ࡀࢇࢭࣥࢱ࣮◊✲ᡤࠊ2010.2.22
㸨>@ ὠୗⱥ᫂㸸⣽⳦࠾ࡼࡧ࢘ࣝࢫឤᰁࡢᵓ㐀⏕≀Ꮫ ➨㸲ᅇᏛ⾡ࣇࣟࣥࢸࢩ࣏ࣥࢪ࢘
࣒ࠕX ⥺⤖ᬗᵓ㐀ゎᯒ㉁㔞ศᯒࡼࡿ⏕⌮άᛶ⺮ⓑ㉁ࡢᵓ㐀ᶵ⬟┦㛵ࡢ◊✲ࠖᚨᓥᩥ⌮
Ꮫࠊ2010.1.30
䠘◊✲ᡂᯝ䛾බ㛤≧ἣ䠚䠄ୖグ௨እ䠅㻌
ᵳ㻌
䠆㼇㻝㼉
ᵳබ୍䠖ே䛾⏕ά䛸ື≀䛾Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶Ᏻᚰ䟿ᐙ␆䛾ᗣ㻌 ி㒔ᕷ㻌 㻌 㻞㻜㻝㻞 ᖺ
㻥 ᭶ 㻝㻣 ᪥㻌
䠆㼇㻞㼉
ᵳබ୍䠖ே⋇ඹ㏻ឤᰁ䛾ඛᅇ䜚ண㜵⟇䠊㛗ᓮᏛᅜ㝿㐃ᦠ◊✲ᡓ␎ᮏ㒊ദ㻌 ➨ 㻞 ᅇ䝞䜲䜸䝉䜻䝳䝸䝔䜱䝽
䞊䜽䝅䝵䝑䝥䛂䝞䜲䜸䝕䜱䝣䜱䜶䞁䝇䛻㈨䛩䜛᪥⡿⛉Ꮫᢏ⾡༠ຊ䛾᪂䛯䛺ྍ⬟ᛶ䛃㻌 㻌 ᮾி㒔 ༊㻌 㻞㻜㻝㻞 ᖺ 㻣 ᭶ 㻞㻝 ᪥
䠆㼇㻟㼉
ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛜⏕䜎䜜䜛䛛䠛㻌 ♫ᅋἲே㈡┴⸆ᖌ㻌
ദ㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ཬ䜃つᶍ⅏ᐖᑐ⟇◊ಟ㻌 ㈡┴ⲡὠᕷ㻌 㻌 㻞㻜㻝㻞 ᖺ 㻡 ᭶ 㻝㻟 ᪥㻌
䠆㼇㻠㼉
ᵳබ୍䠖ୡ⏺䛿㫽䜲䞁䝣䝹䜶䞁䝄䛾ᙉẘᛶኚ␗䛻䛹䛖❧䛱ྥ䛛䛖䛾䛛䠊ᖹᡂ 㻞㻠 ᖺᗘ⛉Ꮫ◊✲㈝⿵ຓ㔠䠄ᇶ┙㻌
䠄㻮䠅୍⯡◊✲䠅᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䝉䝭䝘䞊㻌 ᮾி㒔ᩥி༊㻌 㻞㻜㻝㻞 ᖺ 㻡 ᭶ 㻣 ᪥㻌
䠆㼇㻡㼉
ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾㜵ᑐ⟇䠊㟼ᒸ┴䝨䝇䝖䝁䞁䝖䝻䞊䝹༠ദ㻌 㫽䜲䞁䝣䝹䜶䞁䝄◊ಟ㻌 㟼ᒸᕷ㻌
㻞㻜㻝㻞 ᖺ 㻞 ᭶ 㻝 ᪥㻌
䠆㼇㻢㼉
ᵳබ୍䠖䜰䝆䜰ᇦ䛷ὶ⾜䛜Ṇ䜎䜙䛺䛔㫽䜲䞁䝣䝹䜶䞁䝄䛾ᐇែ䛸ᚋ䛾ぢ㏻䛧䠊බ┈㈈ᅋἲே༓㔛䝷䜲䝣䝃㻌
䜲䜶䞁䝇⯆㈈ᅋദ㻌 㻌 ༓㔛䝷䜲䝣䝃䜲䜶䞁䝇䝣䜷䞊䝷䝮㻔㻞㻜㻝㻝 ᖺ 㻝㻞 ᭶ᗘ㻕㻌 㻌 㜰ᗓ㇏୰ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻞 ᭶ 㻝㻡 ᪥
䠆㼇㻣㼉
ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸ᑐ⟇䠊ᮾᐩኈ㎰⏘ᰴᘧ♫ദ㻌 䝢䝡䜸◊✲㻌 ᮾி㒔ᩥி༊㻌 㻌 㻞㻜㻝㻝 ᖺ㻌
㻝㻞 ᭶ 㻝 ᪥㻌
䠆㼇㻤㼉
ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇ᣑ䛾ཎᅉ⪃ᐹ䛻䛴䛔䛶䠊♫ᅋἲே᪥ᮏ䝨䝇䝖䝁䞁䝖䝻䞊䝹༠ദ㻌
ᖹᡂ 㻞㻟 ᖺᗘឤᰁᣦᑟ⪅ㅮ⩦㻌 ᮾி㒔ቚ⏣༊㻌 㻞㻜㻝㻝 ᖺ 㻝㻝 ᭶ 㻞㻡 ᪥㻌
䠆㼇㻥㼉
ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙䛾᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ฟ⌧䛾ྍ⬟ᛶ䛸㜵ᑐ⟇䛻䛴䛔䛶䠊㈡┴ᗣ
⚟♴㒊ദ㻌 ᖹᡂ 㻞㻟 ᖺᗘື≀⏤᮶ឤᰁᑐ⟇◊ಟ㻌 ὠᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻝 ᭶ 㻞㻠 ᪥㻌
䠆㼇㻝㻜㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾᭱㏆䛾ືྥ䠊රᗜ┴ጲ㊰ᐙ␆ಖ⾨⏕ᡤദ㻌 㣴㭜ㅮ⩦㻌 රᗜ┴ຍ㻌
すᕷ 㻞㻜㻝㻝 ᖺ 㻝㻝 ᭶ 㻞㻝 ᪥㻌
䠆㼇㻝㻝㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊♫ᅋἲேᒸᒣ┴⋇་ᖌദ㻌 ᖹᡂ 㻞㻟 ᖺᗘ⋇་බ⾗⾨⏕ㅮ⩦䠄୰ᅜ㻌
ᆅ༊䠅㻌 㻌 㻌 ᒸᒣᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻝 ᭶ 㻝㻤 ᪥㻌
−26−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠆㼇㻝㻞㼉 ᵳබ୍䠖᭱㏆䛾㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䠊♫ᅋἲே㜰ᗓ␆⏘ദ㻌 ⮬⾨㜵◊ಟ㻌 㜰ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻝㻌
᭶ 㻝㻣 ᪥㻌
䠆㼇㻝㻟㼉 ᵳබ୍䠖᭱㏆䛾㫽䜲䞁䝣䝹䜶䞁䝄䛾ືྥ䛸ᑐ⟇䛻䛴䛔䛶䠊㜰ᗓ䛸㜰⚄ᆅ༊ឤᰁ᠓ヰ䠄㜰᳨ᡤ䚸㛵す
✵ ᳨ᡤ䚸⚄ᡞ᳨ᡤ䛷ᵓᡂ䠅ඹദ㻌 ឤᰁᢸᙜ⪅◊ಟ㻌 㜰ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻝 ᭶ 㻣 ᪥㻌
䠆㼇㻝㻠㼉 ᵳබ୍䠖᭱㏆䛾㫽䜲䞁䝣䝹䜶䞁䝄䛾ືྥ䛸᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䠊᪥❧䜰䝥䝷䜲䜰䞁䝇ദ㻌 㻌 ᪥❧≉ูㅮ㻌
₇㻌 㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻝㻡㼉 ᵳබ୍䠖㎰Ꮫᩍ⫱䛾䛒䜙䜎䛧䛸㫽䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛◊✲ᴫせ䛻䛴䛔䛶䠊㟼ᒸ┴❧㟼ᒸ㧗➼Ꮫᰯദ㻌 ᖹ㻌
ᡂ 㻞㻟 ᖺᗘ㐍㊰ㅮ₇㻌 㟼ᒸᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻞㻝 ᪥㻌
䠆㼇㻝㻢㼉 ᵳබ୍䠖䜲䞁䝣䝹䜶䞁䝄䛛䜙ᐙ᪘䜢Ᏺ䜛䠊䠪䠤䠧ᩥ䝉䞁䝍䞊㜰⥲ᨭ♫ദ㻌 㻌 䝇䝈䜿䞁ᕷẸㅮᗙ㻌 㜰ᕷ㻌
㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻝㻣㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾᭱㏆䛾ືྥ䛻䛴䛔䛶䠊㭜◊✲㧗▱┴ᨭ㒊ദ㻌 ᖹᡂ 㻞㻟 ᖺᗘ୰ᅜᅄᅜᆅ༊㭜
ᢏ⾡◊ಟ㻌 ≉ูㅮ₇㻌 㧗▱ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻝㻠 ᪥㻌
䠆㼇㻝㻤㼉 ᵳබ୍䠖䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛻䛴䛔䛶䠊ி㒔ᗓ❧་⛉Ꮫ㠀ᖖㅮᖌ㻌 ி㒔ᕷ㻌 㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻝㻞 ᪥㻌
䠆㼇㻝㻥㼉 ᵳබ୍䠖㔝㫽䛻䛚䛡䜛㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾ఏᦙ䛾⤌䜏䠊♫ᅋἲேᒱ㜧┴⋇་ᖌദ㻌 㻌 ᖹᡂ 㻞㻟㻌
ᖺᗘ⋇་Ꮫ⾡◊ಟ䠄യ㔝⏕㫽⋇ಖㆤ䠅㻌 ᒱ㜧ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻞㻜㼉 ᵳබ୍䠖Ⓨ⏕䛜Ṇ䜎䜙䛺䛔㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊㭜◊✲ዉⰋ┴ᨭ㒊ദ㻌 ᖹᡂ 㻞㻟 ᖺᗘ㏆␥ᆅ༊㭜
ᢏ⾡◊ಟ㻌 ≉ูㅮ₇㻌 ዉⰋᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻣 ᪥㻌
䠆㼇㻞㻝㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ㻌 䛸䜚䞉䛯䜎䛤䛾㞟䛔㻌 ி㻌
㒔ᗓ⯙㭯ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻝㻜 ᭶ 㻝 ᪥㻌
䠆㼇㻞㻞㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ㻌 䛸䜚䞉䛯䜎䛤䛾㞟䛔㻌 㻌 ி
㒔ᕷ㻌 㻌 㻞㻜㻝㻝 ᖺ 㻥 ᭶ 㻞㻟 ᪥㻌
䠆㼇㻞㻟㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾Ⓨ⏕䛸ධ㜵Ṇᑐ⟇䛻䛴䛔䛶䠊㭜◊✲ᒣཱྀ┴ᨭ㒊ദ㻌 㻌 ᖹᡂ 㻞㻟 ᖺ
ᗘ㭜◊✲ᒣཱྀ┴ᨭ㒊㭜ᢏ⾡◊ಟ㻌 ≉ูㅮ₇㻌 ᒣཱྀᕷ㻌 㻞㻜㻝㻝 ᖺ 㻥 ᭶ 㻞㻜 ᪥㻌
䠆㼇㻞㻠㼉 ᵳබ୍䠖ⓑ㫽䜈䛾⤥㣵䜢⪃䛘䜛䡚ே䛸㔝㫽䛾㛵䜟䜚᪉䛸㫽䜲䞁䝣䝹䜶䞁䝄䛾ၥ㢟䜢㏻䛧䛶䡚䠊㛗㔝┴Ᏻ㔝ᕷ㻌
ദ䝅䞁䝫䝆䜴䝮䛄ⓑ㫽䜈䛾㣵䛡䛻䛴䛔䛶䛅㻌 㛗㔝┴Ᏻ㔝ᕷ㻌 㻌 㻞㻜㻝㻝 ᖺ 㻥 ᭶ 㻟 ᪥㻌
䠆㼇㻞㻡㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾᪂䛯䛺≧ἣ䜈䛾ᑐᛂ⟇䛻䛴䛔䛶䠊ᐙ⚺Ꮫദ㻌 ᖹᡂ 㻞㻟 ᖺᗘ䞉ᐙ⚺Ꮫ⛅Ꮨ㻌
බ㛤䝅䞁䝫䝆䜴䝮㻌 㟷᳃┴༑⏣ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻤 ᭶ 㻞㻠 ᪥㻌
䠆㼇㻞㻢㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸ᑐ⟇䠊ᮾᾏ␆⏘Ꮫദ㻌 ᖹᡂ 㻞㻟 ᖺᗘᮾᾏ␆⏘Ꮫ䝅䞁䝫䝆䜴䝮㻌 㻌 ྡྂ
ᒇᕷ㻌 㻌 㻞㻜㻝㻝 ᖺ 㻣 ᭶ 㻢 ᪥㻌
䠆㼇㻞㻣㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄Ⓨ⏕䛻㛵䛩䜛᭱᪂䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌
㻌 䛄➨ 㻞 ᅇ䛂㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛃䛻ಀ䜛㜵ᑐ⟇㆟䛅㻌 ி㒔ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻡 ᭶ 㻟㻜 ᪥㻌
䠆㼇㻞㻤㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾Ⓨ⏕≧ἣ䛸䛭䛾ᑐ⟇䠊᪥ᮏ㜵⳦㜵㰄ᏛᏛ⾡ㅮ₇ 㻞㻜㻝㻝 ཬ䜃➨ 㻟㻥 ᅇ㏻ᖖ⥲㻌
㻌 㻌 ᪥ᮏ㜵⳦㜵㰄Ꮫദ㻌 㜰ᗓ྿⏣ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻡 ᭶ 㻞㻟 ᪥㻌
䠆㼇㻞㻥㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄ཬ䜃᪂ᆺ䜲䞁䝣䝹䜶䞁䝄㜵ᑐ⟇☜❧䛸ឤᰁᑐ⟇䠊ᆅ⌫┈䠬䠃䠟◊✲ᡤദ㻌 ி㻌
㒔ᕷ㻌 㻌 㻞㻜㻝㻝 ᖺ 㻠 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻟㻜㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾ὶ⾜≧ἣ䠊䠄♫䠅᪥ᮏ䛧䜝䛒䜚ᑐ⟇༠㛵すᨭ㒊ദ㻌 ➨ 㻠㻟 ᅇ䠄ᖹᡂ 㻞㻟 ᖺᗘ䠅ᨭ㒊
㻌 ㏻ᖖ⥲㻌 㜰ᕷ㻌 㻞㻜㻝㻝 ᖺ 㻞 ᭶ 㻝㻜 ᪥㻌
䠆㼇㻟㻝㼉 ᵳබ୍䠖䛂㧗ཎᛶ㫽䡮䢙䢈䢕䡰䢙䡷䢚䛾ฟ⌧ண 䜔ὶ⾜ண 䚸ᅜෆධ⤒㊰䛾ゎ᫂䛃ཬ䜃䛂㧗ཎᛶ㫽䡮䢙䢈䢕䡰䢙䡷䢚㻌
䛾ᅜෆእ䛷䛾㜵యไ䛃䠄♫䠅⩌㤿┴␆⏘༠ദ㻌 㧗ཎᛶ㫽䡮䢙䢈䢕䡰䢙䡷䢚㜵◊ಟ㻌 ⩌㤿┴๓ᶫᕷ㻌 㻞㻜㻝㻝 ᖺ 㻞
᭶ 㻝 ᪥㻌
䠆㼇㻟㻞㼉 ᵳබ୍䠖ᓥ᰿┴䛷䛾Ⓨ⏕≧ἣ䛺䛹㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊ி㒔ᗓ༴ᶵ⟶⌮䞉㜵⅏ㄢദ㻌 㻌 ᗓẸ䜈䛾⥭ᛴ㻌
−27−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ሗఏ㐩◊✲䠄≉ู⦅䠅㻌 ி㒔ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝㻞 ᭶ 㻞㻝 ᪥㻌
䠆㼇㻟㻟㼉 ᵳබ୍䠖୰ᾏ䛷㉺䛩䜛Ώ䜚㫽䛸㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䠊㫽ྲྀᏛ⏘Ꮫ䞉ᆅᇦ㐃ᦠ᥎㐍ᶵᵓ♫㈉⊩ᐊ㻌
㻌 㻌 㻌 ദ㻌 㻌 ᒣ䞉᪥㔝ᕝ䞉୰ᾏᏛ༠䝉䝭䝘䞊㻌 㫽ྲྀᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝㻝 ᭶ 㻞㻜 ᪥㻌
䠆㼇㻟㻠㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䚸ཱྀ㋟䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ㻌 䛸䜚䞉䛯䜎䛤䛾㻌
㻌 㻌 㞟䛔㻌 㻌 ி㒔ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝㻝 ᭶ 㻢 ᪥㻌
䠆㼇㻟㻡㼉 ᵳබ୍䠖᭱㏆䛾㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䠊♫ᅋἲே㜰ᗓ␆⏘ദ㻌 ⮬⾨㜵◊ಟ㻌 㜰ᕷ㻌
㻞㻜㻝㻜 ᖺ 㻝㻝 ᭶ 㻡 ᪥㻌
䠆㼇㻟㻢㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䚸ཱྀ㋟䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ㻌 䛸䜚䞉䛯䜎䛤䛾㻌
㞟䛔㻌 㻌 ி㒔ᗓ⥤㒊ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝㻜 ᭶ 㻟㻜 ᪥㻌
䠆㼇㻟㻣㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛸㫽䜲䞁䝣䝹䜶䞁䝄㻚ᒣཱྀᏛ㎰Ꮫ㒊ദ㻌 ᒣཱྀᏛ㎰Ꮫ㒊㻌 ⋇་Ꮫ⛉≉㻌
ู䝉䝭䝘䞊㻌 ᒣཱྀᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝㻜 ᭶ 㻞㻥 ᪥㻌
䠆㼇㻟㻤㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛸㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇㻚᪥❧䜰䝥䝷䜲䜰䞁䝇ദ䛄᪥❧䛂す᪥ᮏ≉⣙䞉㻌
㈍ᗑᵝ䛃㈍㆟䝉䝭䝘䞊䛅㻌 㜰ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻡 ᭶ 㻣 ᪥㻌
䠆㼇㻟㻥㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛸㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇㻚㏆␥ᆅ༊≉ูᨭᏛᰯ⫥య⮬⏤ᩍ⫱ᰯ㛗㻌
ദᖹᡂ 㻞㻝 ᖺᗘ➨ 㻞 ᅇ◊✲༠㆟㻌 ி㒔ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻟 ᭶ 㻠 ᪥㻌
䠆㼇㻠㻜㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛸㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇㻚රᗜ┴ᗣ⏕ά⛉Ꮫ◊✲ᡤദᖹᡂ 㻞㻝 ᖺᗘ
රᗜ┴❧ᗣ⏕ά⛉Ꮫ◊✲ᡤㅮ₇㻌 ⚄ᡞᕷ㻌 㻞㻜㻝㻜 ᖺ 㻞 ᭶ 㻝㻣 ᪥㻌
䠆㼇㻠㻝㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾≉ᚩ㻚య㉁◊✲ദ㻌 ➨ 㻝㻠 ᅇ䛔䛾䛱䛾⛉Ꮫ䝣䜷䞊䝷䝮ᕷẸබ㛤ㅮᗙ㻌
ி㒔ᕷ㻌 㻞㻜㻝㻜 ᖺ 㻝 ᭶ 㻝㻢 ᪥㻌
䠆㼇㻠㻞㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾ᑐᛂ䠉䜴䜲䝹䝇Ꮫⓗぢᆅ䛛䜙䠉㻚ᅧ᪂⪺♫ദ㻌 㔠ἑᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻞 ᭶ 㻝㻥 ᪥㻌
䠆㼇㻠㻟㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䛾ᑐᛂ䠉䜴䜲䝹䝇Ꮫⓗぢᆅ䛛䜙䠉䠊ᆅ᪉⾨⏕◊✲ᡤᅜ༠㆟㏆␥ᨭ㒊ദ㻌
➨ 㻞㻡 ᅇᆅ᪉⾨⏕◊✲ᡤᅜ༠㆟㏆␥ᨭ㒊Ꮫሗ㒊ᐃᮇ◊✲㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻞 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻠㻠㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔⏘ᴗᏛྠ❆ദ㻌 ி㒔⏘ᴗᏛ㻌 ྠ❆⥲㻌
㻌 㔠ἑᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻞 ᭶ 㻡 ᪥㻌
䠆㼇㻠㻡㼉 ᵳබ୍䠖᭱㏆䛾㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䠊♫ᅋἲே㜰ᗓ␆⏘ദ㻌 ⮬⾨㜵◊ಟ㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶
㻞㻣 ᪥㻌
䠆㼇㻠㻢㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛᭱᪂䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓ༡ᐙ␆ಖ⾨⏕ᡤദ㻌 டᒸᕷ㻌
㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻞㻢 ᪥㻌
䠆㼇㻠㻣㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛚䜘䜃ᐙ⚺䜴䜲䝹䝇ᛶ䠊㎰ᯘỈ⏘┬ᾘ㈝䞉Ᏻᒁദ㻌 ᖹᡂ 㻞㻝 ᖺᗘᐙ␆⾨⏕◊
ಟ㻌 䛴䛟䜀ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻞㻡 ᪥㻌
䠆㼇㻠㻤㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛᭱᪂䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓ୰ᐙ␆ಖ⾨⏕ᡤദ㻌 ⚟▱ᒣᕷ
㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻞㻠 ᪥㻌
䠆㼇㻠㻥㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛸䛭䛾ண㜵䠊ி㒔⏘ᴗᏛྠ❆ദ㻌 ி㒔⏘ᴗᏛྠ❆⥲㻌 ᯇᒣᕷ㻌 㻞㻜㻜㻥㻌
ᖺ 㻝㻝 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻡㻜㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾ᚋ䛾ືྥ䛻䛴䛔䛶䠊ྡྂᒇᕷᾘ㜵ᒁ䛸≉ᐃ㠀Ⴀάືἲேឡ▱༤グᛕ⅏㻌
ᐖ䞉ᩆᛴ་⒪◊✲ඹദ㻌 ➨ 㻟㻝 ᅇᩆᛴ䝁䞉䝯䝕䜱䜹䝹䝉䝭䝘䞊ᩍ⫱ㅮ₇㻌 ྡྂᒇᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻝㻞 ᪥㻌
䠆㼇㻡㻝㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸ᑐ⟇䠊㖡ཬ䜃㖡ྜ㔠ᢏ⾡◊✲ദ㻌 㖡ཬ䜃㖡ྜ㔠ᢏ⾡◊✲➨ 㻠㻥 ᅇ㻌
ㅮ₇㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻡㻞㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊᪥ᮏᗈሗᏛ㛵す㒊ദ㻌 ᪥ᮏᗈሗᏛ㛵す㒊㻌
䛂ᗈሗሿ䛃㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻣 ᪥㻌
䠆㼇㻡㻟㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䡚㜵ᑐ⟇☜❧䛾䛯䜑䛻䡚䠊㛵す⚟♴Ꮫദ㻌 ᖹᡂ 㻞㻝 ᖺᗘ㛵す⚟♴Ꮫබ㛤
ㅮ₇㻌 ㉥✑ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻠 ᪥㻌
−28−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠆㼇㻡㻠㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔⏘ᴗᏛദ㻌 ி㒔⏘ᴗᏛ 㻰㻭㼅㻌 㻞㻜㻜㻥㼕㼚 ி㒔㻌
ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻝 ᭶ 㻝 ᪥㻌
䠆㼇㻡㻡㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊㧗▱┴බ⾗⾨⏕⋇་ᖌ༠㆟ദ㻌 ᖹᡂ 㻞㻝 ᖺᗘ㧗▱
┴බ⾗⾨⏕⋇་ᖌ༠㆟◊ಟ㻌 㧗▱ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻟㻝 ᪥㻌
䠆㼇㻡㻢㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔䝰䞊䝙䞁䜾䝻䞊䝍䝸䞊䜽䝷䝤ദ㻌 ி㒔䝰䞊䝙䞁䜾㻌
䝻䞊䝍䝸䞊䜽䝷䝤㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻥 ᪥㻌
䠆㼇㻡㻣㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔ᗓ❧་⛉Ꮫ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻡㻤㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ᗈᇦ㜵ᑐ⟇䝉䞁䝍䞊䛻ಀ䜛ᑓ㻌
㛛ᐙ䝏䞊䝮㆟㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻡㻥㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊㟼ᒸ┴㆟ദ㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇≉ูጤဨ㻌
㟼ᒸᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻣 ᪥㻌
䠆㼇㻢㻜㼉 ᵳබ୍䠖䛒䛺䛯䛾䝟䞁䝕䝭䝑䜽ᑐ⟇䛿㻌 䡚䝇䝨䜲䞁㢼㑧䜢ᩍカ䛻᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜢⪃䛘䜛䡚䠊ᮾி䝡䝑䜾䝃䜲㻌
䝖ദ㻌 ༴ᶵ⟶⌮⏘ᴗᒎ 㻞㻜㻜㻥㻌 䝇䝨䝅䝱䝹䞉䜹䞁䝣䜯䝺䞁䝇༴ᶵ⟶⌮䝉䝭䝘䞊㻌 ᮾி㒔Ụᮾ༊㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻞 ᪥㻌
䠆㼇㻢㻝㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䛾᭱᪂ሗ䛸ᴗ䛷䛾㜵ᑐ⟇䠊≉ᐃ㠀Ⴀάືἲே㻌 ᴗ⥅⥆᥎㐍ᶵ
ᵓ㻔㻮㻯㻭㻻㻕ദ㻌 ᴗ⥅⥆᥎㐍ᶵᵓ㻔㻮㻯㻭㻻㻕㛵すㅮ⩦㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻝 ᪥㻌
䠆㼇㻢㻞㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾᭱㏆䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓദ㻌 ᖹᡂ 㻞㻝 ᖺᗘ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁
䝄㜵₇⩦㻌 டᒸᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞㻜 ᪥㻌
䠆㼇㻢㻟㼉 ᵳබ୍䠖䜲䞁䝣䝹䜶䞁䝄䛿䛺䛬ὶ⾜䜢⧞䜚㏉䛧䛶䛝䛯䛛䠊ி㒔⏘ᴗᏛദ㻌 ி㒔⏘ᴗᏛ 㻰㻭㼅㻌㻞㻜㻜㻥㼕㼚 ᒱ㜧㻌 ᒱ
㜧ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻝㻤 ᪥㻌
䠆㼇㻢㻠㼉 ᵳබ୍䠖䜰䝆䜰䛾㫽䜲䞁䝣䝹䜶䞁䝄Ⓨ⏕≧ἣ䠊㭜◊✲ദ㻌 ᖹᡂ 㻞㻝 ᖺᗘ⛅Ꮨᅜ㭜ᢏ⾡◊ಟ㻌 ி㒔ᕷ
㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻝㻢 ᪥㻌
䠆㼇㻢㻡㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊䞞䝢䞊䝇䜰䞁䝗䜻䝳䞊䝈ദ㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇㻌
ㅮ₇㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻢㻢㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛜᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈ኚ䜟䜛䛸䛝䠊ி㒔⏘ᴗᏛദ䞉ẖ᪥᪂⪺♫ඹദ㻌 ᪂ᆺ䜲㻌
䞁䝣䝹䜶䞁䝄䝅䞁䝫䝆䜴䝮㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻝㻜 ᪥㻌
䠆㼇㻢㻣㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛸䛭䛾ண㜵ᑐ⟇䠊┦ᴦ༊ᇦၟᕤᗈᇦ㐃ᦠ༠㆟ദ㻌 ᴗ㜵⾨䝉䝭䝘䞊㻌 ி㒔㻌
ᗓᮌὠᕝᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻢 ᪥㻌
䠆㼇㻢㻤㼉 ᵳබ୍䠖䜲䞁䝣䝹䜶䞁䝄䛛䜙ᐙ᪘䜢Ᏺ䜛᪉ἲ䠊㻺㻴㻷 ᩥ䝉䞁䝍䞊ி㒔ᨭ♫ദ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻞 ᪥㻌
䠆㼇㻢㻥㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䠉⌧≧䛸䛣䜜䛛䜙䠉䠊ᒱ㜧Ꮫദ㻌 ➨䠍䠓ᅇᒱ㜧䝅䞁䝫䝆䜴䝮䛂᪂ᆺ䜲䞁䝣䝹䜶䞁㻌
䝄䜢⛉Ꮫ䛩䜛䛃㻌 ᒱ㜧ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝㻜 ᭶ 㻝 ᪥㻌
䠆㼇㻣㻜㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ䚸䛸䜚䞉䛯䜎䛤䛾㞟䛔㻌 ⚟▱
ᒣᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻝㻥 ᪥㻌
䠆㼇㻣㻝㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔ᗓ⚾❧୰Ꮫ㧗➼Ꮫᰯ㐃ྜദ㻌 Ꮫᰯົ◊✲㻌
➨ 㻟㻢 ᅇᐇົ◊ಟ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻝㻤 ᪥㻌
䠆㼇㻣㻞㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓ㎰ᯘỈ⏘㒊␆⏘ㄢദ㻌 ▱䛳䛶ᚓ䚸䛸䜚䞉䛯䜎䛤䛾㞟䛔㻌 ி㒔
ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻝㻞 ᪥㻌
䠆㼇㻣㻟㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䛻䛴䛔䛶䠊㜰ᕷ㞀ᐖඣ⪅タ㐃⤡༠㆟ദ㻌 ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛
䝉䝭䝘䞊㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻣㻠㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸ᑐ⟇䠊᪥ᮏ㣗ရᕤᴗᴦ㒊ദ㻌 㣗ရ䛾ရ㉁ಖド᠓ヰ㻌 㜰ᕷ㻌 㻞㻜㻜㻥㻌
ᖺ 㻥 ᭶ 㻝㻜 ᪥㻌
䠆㼇㻣㻡㼉 ᵳබ୍䠖ᅜ㝿⋇ົᒁ䠄䠫䠥䠡䠅ദ㻌 䛂➨ 㻞 ᅇ䠫䠥䠡ᆅᇦ㆟䠄ி㒔㆟䠅䠖䜰䝆䜰䛻䛚䛡䜛㧗ཎᛶ㫽䜲䞁䝣䝹䜶
䞁䝄䠄䠤䠬䠝䠥䠅㜵ᑐ⟇ᙉ㆟㻌 ⚟▱ᒣᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻥 ᪥㻌
−29−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠆㼇㻣㻢㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾ᇶ♏▱㆑䠊㝣㎰ᨻᒁദ㻌 㝣ᆅᇦ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄ᑐ⟇㐃㻌
⤡㆟ཬ䜃ᖹᡂ 㻞㻝 ᖺᗘ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄㜵ᑐᛂྜྠカ⦎㻌 㔠ἑᕷ㻌 㻞㻜㻜㻥 ᖺ 㻥 ᭶ 㻝 ᪥䡚㻥 ᭶ 㻞 ᪥㻌
䠆㼇㻣㻣㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䜈䛾⛣⾜䛜ᠱᛕ䛥䜜䜛㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䠊➨ 㻟㻥 ᅇ୰ᅜ䞉ᅄᅜᏛ
ಖ⟶⌮◊✲㞟㻌 㫽ྲྀᕷ㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻣㻤㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔᪂⪺♫ദ㻌 ி㒔ᨻ⤒ᩥ᠓ヰ 㻤 ᭶㻌 ி㒔
ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻞㻡 ᪥㻌
䠆㼇㻣㻥㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ὶ⾜㻌 ➨䠎Ἴ䛻ഛ䛘䛶䠊ி㒔ᕷᾘ㜵ᒁᖿ㒊⫋ဨ◊ಟ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻞㻠 ᪥
䠆㼇㻤㻜㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛸ᑐ⟇䞉ᅜෆእ䛾᭱᪂䛾᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾ሗ䛸䛭䛾ᑐ⟇䠊㻮㻹㻮䠄䝡䝹䡡䝬䝛䝆㻌
䝯䞁䝖䞉䝡䝆䝛䝇䠅◊✲㻌 ᮾி㒔 ༊㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻞㻜 ᪥㻌
䠆㼇㻤㻝㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䛾᭱᪂ሗ䛸ᴗ䛷䛾㜵ᑐ⟇䠊≉ᐃ㠀Ⴀάືἲே㻌 ᴗ⥅⥆᥎㐍ᶵ
ᵓ㻔㻮㻯㻭㻻㻕㻤 ᭶ᗘ᭶㻌 ᮾி㒔㇂༊㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻝㻥 ᪥㻌
䠆㼇㻤㻞㼉 ᵳබ୍䠖ື≀䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊䞞䝢䞊䝇䜰䞁䝗䜻䝳䞊䝈ദ㻌 㻞㻜㻜㻥 ᖺ᪂ᆺ䜲䞁䝣䝹䜶䞁
䝄ᑐ⟇䝉䝭䝘䞊㻌 ᮾி㒔༓௦⏣༊㻌 㻞㻜㻜㻥 ᖺ 㻤 ᭶ 㻢 ᪥㻌
䠆㼇㻤㻟㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄୪䜃䛻᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾᭱᪂䛾▱ぢ䛻䛴䛔䛶䠊ᖹᡂ 㻞㻝 ᖺᗘරᗜ┴㣗⫗
⾨⏕᳨ᰝဨᴗົ◊ಟ㻌 ⚄ᡞᕷ㻌 㻞㻜㻜㻥 ᖺ 㻣 ᭶ 㻞㻥 ᪥㻌
䠆㼇㻤㻠㼉 ᵳබ୍䠖䞞་⸆䝆䝱䞊䝘䝹♫䛾㞧ㄅ䛂Ꮫ⒪ἲ䛾㡿ᇦ䛃䛾᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛ᗙㄯ䠊ᮾி㒔༓௦⏣༊
㻞㻜㻜㻥 ᖺ 㻣 ᭶ 㻞㻣 ᪥㻌
䠆㼇㻤㻡㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾⬣ጾ䛸ᑐᛂ᪉ἲ䠊Ꮫᰯ䝸䝇䜽䝬䝛䝆䝯䞁䝖᥎㐍ᶵᵓദ⚾❧Ꮫᰯ⟶⌮⪅ྥ䛡䛾◊ಟ
㻌 ᮾி㒔༓௦⏣༊㻌 㻞㻜㻜㻥 ᖺ 㻣 ᭶ 㻝 ᪥䞉㻞㻜㻜㻥 ᖺ 㻣 ᭶ 㻤 ᪥㻌
䠆㼇㻤㻢㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛸䝟䞁䝕䝭䝑䜽䠊୰㒊Ꮫ䝦䝹䝇䝃䜲䜶䞁䝇䝠䝹䝈ᡂᯝⓎ⾲ཬ䜃㛤タグᛕㅮ₇㻌
᪥ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻡 ᭶ 㻞㻣 ᪥㻌
䠆㼇㻤㻣㼉 ᵳබ୍䠖ୡ⏺䛾㫽䜲䞁䝣䝹䜶䞁䝄Ⓨ⏕ᣑ䛸᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䠊➨ 㻡㻜 ᅇ᪥ᮏ⏕Ꮫ୰ᅜ䞉ᅄᅜᨭ㒊㻌 㫽
ྲྀᕷ㻌 㻞㻜㻜㻥 ᖺ 㻡 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻤㻤㼉 ᵳබ୍䠖䛄᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䡚ண䛥䜜䛺䛛䛳䛯䜴䜲䝹䝇䛾Ⓩሙ䛅⌧ᅾⓎ⏕䛧䛶䛔䜛᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛾⌧≧
䛚䜘䜃䛭䛾ศᯒ䠊᪥ᮏ䝔䝺䝡㻌 ᮾி㒔 ༊㻌 㻞㻜㻜㻥 ᖺ 㻡 ᭶ 㻝㻟 ᪥㻌
䠆㼇㻤㻥㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊་⒪ἲே㈈ᅋᗣ⏕Ṋ⏣㝔ദ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻠 ᭶
㻞㻠 ᪥㻌
䠆㼇㻥㻜㼉 ᵳබ୍䠖䛄᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛺䛹䛾ឤᰁ䜔㣗୰ẘ䛛䜙㌟䜢Ᏺ䜛⾨⏕⩦័䛾ᚲせᛶ䛅䡚ឤᰁ䜔㣗୰ẘ䛛䜙㻌
㌟䜢Ᏺ䜛䛯䜑䛻⚾䛯䛱䛜䛷䛝䜛䛣䛸䛿䡚䠊႐ከ⸆ရᕤᴗ䞞ദ➨ 㻞 ᅇ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䝉䝭䝘䞊㻌 ᮾி㒔᪂
ᐟ༊㻌 㻞㻜㻜㻥 ᖺ 㻠 ᭶ 㻞㻞 ᪥㻌
䠆㼇㻥㻝㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊♫ᅋἲேி㒔ᗓ⸆ᖌദᖹᡂ 㻞㻜 ᖺᗘ㏻ᖖ௦㆟ဨ㻌
䞉⮫⥲㻌 ≉ูㅮ₇㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻟 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻥㻞㼉 ᵳබ୍䠖ឡ▱┴䛷Ⓨ⏕䛧䛯㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛻㛵䛧䛶䡚䠤䠓ளᆺ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛻㻌
䛴䛔䛶䡚䠊ி㒔ᗓദᗈᇦ㜵ᑐ⟇䝉䞁䝍䞊䛻ಀ䜛ᑓ㛛ᐙ䝏䞊䝮㆟㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻟 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻥㻟㼉 ᵳබ୍䠖ឤᰁ䜔㣗୰ẘ䛛䜙㌟䜢Ᏺ䜛䛯䜑䛻⚾䛯䛱䛜䛷䛝䜛䛣䛸䛿䠊႐ከ⸆ရᕤᴗ䞞ദ䛄᪂ᆺ䜲䞁䝣䝹䜶䞁䝄㻌
䛺䛹䛾ឤᰁ䜔㣗୰ẘ䛛䜙㌟䜢Ᏺ䜛⾨⏕⩦័䛾ᚲせᛶ䛅䝉䝭䝘䞊㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻞 ᭶ 㻞㻢 ᪥㻌
䠆㼇㻥㻠㼉 ᵳබ୍䠖䜲䞁䝣䝹䜶䞁䝄ᇶ♏▱㆑䚸䝗䝻䝬䜲䝖䛺䛹䛾᪂⣲ᮦ䜢⏝䛔䛯᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䠊䠥䠯䠯⏘ᴗ⛉Ꮫ䝅䝇㻌
䝔䝮䝈ദ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇᭱๓⥺䝉䝭䝘䞊㻌 ᮾி㒔༓௦⏣༊㻌 㻞㻜㻜㻥 ᖺ 㻞 ᭶ 㻝㻥 ᪥㻌
䠆㼇㻥㻡㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛸㣗䛾Ᏻᛶ䠊᪥ᮏ㣗ရᕤᴗᴦ㒊㜰㒊 㻞㻜㻜㻥 ᖺ 㻞 ᭶㻌 㜰ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻞㻌
᭶ 㻝㻣 ᪥㻌
䠆㼇㻥㻢㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸Ⓨ⏕㜵Ṇ䛾␃ពⅬ䠊㜰ᗓ␆⏘ദ㣴㭜㜵◊ಟ㻌 㜰ᕷ㻌
㻞㻜㻜㻥 ᖺ 㻝 ᭶ 㻟㻜 ᪥㻌
−30−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠆㼇㻥㻣㼉 ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ⟇䛾䛯䜑䛾ᇶᮏⓗ▱㆑䠊㫽ྲྀᕷᩍ⫱ጤဨദ㫽ྲྀᕷᑠ䞉୰Ꮫᰯ㣴ㆤᩍㅍ◊ಟ
㻌 㫽ྲྀᕷ㻌 㻞㻜㻜㻥 ᖺ䠍᭶ 㻞㻟 ᪥㻌
䠆㼇㻥㻤㼉 ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ி㒔ၟᕤ㆟ᡤദᴗ䛾䛯䜑䛾᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ᑐ
⟇䝉䝭䝘䞊㻌 ி㒔ᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝 ᭶ 㻝㻡 ᪥㻌
䠆㼇㻥㻥㼉 ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾ୡ⏺ⓗືྥ䠊䝞䜲䜸䜶䜰䝻䝌䝹◊✲ദ➨ 㻟 ᅇẼ䝞䜲䜸䜶䜰䝻䝌䝹䝅
䞁䝫䝆䝳䞊䝮㻌 ྎᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻝㻜㻜㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊㫽ྲྀᕷ୰ኸಖ䝉䞁䝍䞊ദ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄ㅮ₇㻌
㫽ྲྀᕷ㻌 㻞㻜㻜㻥 ᖺ 㻝 ᭶ 㻥 ᪥㻌
䠆㼇㻝㻜㻝㼉ᵳබ୍䠖䜑䛠䜛䚸ឤᰁ䛭䛧䛶◊✲䛾䠊⛉Ꮫᢏ⾡⯆ㄪᩚ㈝㐃ᦠ⟇䛂⛉Ꮫᢏ⾡㐃ᦠ⟇⩌䛾ຠᯝⓗ䞉ຠ⋡㻌
ⓗ䛺᥎㐍 㻮㻿㻸䠉㻠 タ䜢ᚲせ䛸䛩䜛᪂⯆ឤᰁᑐ⟇䛃䝃䝤䝔䞊䝬 㻠䠄㈐௵⪅䠖ⱥ䠅䛂㻮㻿㻸䠉㻠 タ䛻㛵䛩䜛䝸䝇
䜽䝁䝭䝳䝙䜿䞊䝅䝵䞁䛻㛵䛩䜛◊✲䛃䝅䞁䝫䝆䜴䝮㻌 㛗ᓮᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻞 ᭶ 㻞㻝 ᪥㻌
䠆㼇㻝㻜㻞㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾᭱㏆䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓᒣᇛᐙ␆ಖ⾨⏕ᡤദ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄
䛻㛵䛩䜛ሗ㻌 ி㒔ᗓᏱᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻞㻣 ᪥㻌
䠆㼇㻝㻜㻟㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊᪥ᮏ་⸆༺ົ⸆ᖌி㒔ᗓᨭ㒊ദᏛ⾡ㅮ₇㻌
ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻞㻣 ᪥㻌
䠆㼇㻝㻜㻠㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾㜵ᑐ⟇➼䠊ி㒔ᕷദி㒔ᕷ㆟ဨ◊ಟ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻝㻤 ᪥㻌
䠆㼇㻝㻜㻡㼉ᵳබ୍䠖䜾䝻䞊䝞䝹䛸㫽䜲䞁䝣䝹䜶䞁䝄ၥ㢟䠊᪥ᮏ⎔ቃື≀᪻Ꮫ❧ 㻞㻜 ࿘ᖺグᛕ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ
㻝㻝 ᭶ 㻝㻢 ᪥㻌
䠆㼇㻝㻜㻢㼉ᵳබ୍䠖᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䛻㛵䛩䜛᭱᪂ሗ䠊䜶䝹䜽䝁䞊䝫䝺䞊䝅䝵䞁ദ➨ 㻞㻜 ᅇ䜶䝹䜽⥲㻌 ᮾி㒔 ༊
㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻝㻟 ᪥㻌
䠆㼇㻝㻜㻣㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛳䛶䛹䛖䛔䛖Ẽ䠊ி㒔ᗓദ▱䛳䛶ᚓ㻌 䛸䜚䞉䛯䜎䛤䛾㞟䛔㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻤㻌
᪥㻌
䠆㼇㻝㻜㻤㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾⌧≧䛸ㄢ㢟䛻䛴䛔䛶䠊㛗㔝┴㎰ᨻ㒊ദ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄ㅮ⩦㻌 ᯇᮏᕷ
㻞㻜㻜㻤 ᖺ 㻝㻝 ᭶ 㻣 ᪥㻌
䠆㼇㻝㻜㻥㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛾༴ᶵ⟶⌮䛻䛴䛔䛶䠊బୡಖᕷ㣗⫗⾨⏕᳨ᰝᡤ㻌 బୡಖᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻜 ᭶ 㻟㻝 ᪥㻌
䠆㼇㻝㻝㻜㼉ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛾᭱㏆䛾▱ぢ䛻䛴䛔䛶䠊ி㒔ᗓദᖹᡂ 㻞㻜 ᖺᗘ㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄
㜵₇⩦㻌 டᒸᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻜 ᭶ 㻞㻥 ᪥㻌
䠆㼇㻝㻝㻝㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊ி㒔ᗓദ➨ 㻟 ᅇ䛝䜗䛖䛸㣗䛾Ᏻᚰ䞉Ᏻពぢ㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻝㻜
᭶ 㻝㻡 ᪥㻌
䠆㼇㻝㻝㻞㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊䜰䝹䝪䞊䝇ദ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䝉䝭䝘䞊㻌 ྡྂᒇᕷ㻌
㻞㻜㻜㻤 ᖺ 㻝㻜 ᭶ 㻥 ᪥㻌
䠆㼇㻝㻝㻟㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊༓ⴥ⛉ᏛᏛദ 㼀㼔㼑㻌㻵㼚㼠㼑㼞㼚㼍㼠㼕㼛㼚㼍㼘㻌㻯㼞㼕㼟㼕㼟㻌㻹㼍㼚㼍㼓㼑㼙㼑㼚㼠㻌㻿㼥㼙㼜㼛㼟㼕㼡㼙㻌㼛㼚㻌
㻯㻮㻾㻺㻌㻔㻺㻮㻯㻕㻌㼍㼚㼐㻌㻱㼙㼑㼞㼓㼕㼚㼓㻌㻵㼚㼒㼑㼏㼠㼕㼛㼡㼟㻌㻰㼕㼟㼑㼍㼟㼑㼟㻌 㖯Ꮚᕷ㻌 㻞㻜㻜㻤 ᖺ 㻥 ᭶ 㻝㻟 ᪥䡚㻥 ᭶ 㻝㻠 ᪥㻌
䠆㼇㻝㻝㻠㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊䜰䝹䝪䞊䝇ദ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䝉䝭䝘䞊㻌 㜰ᕷ㻌 㻞㻜㻜㻤㻌
ᖺ 㻥 ᭶ 㻝㻝 ᪥㻌
䠆㼇㻝㻝㻡㼉ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊ᗈᇦ㜵ᑐ⟇䝉䞁䝍䞊䛻ಀ䜛ᑓ㛛ᐙ䝏䞊䝮㆟㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ
㻥 ᭶ 㻥 ᪥㻌
䠆㼇㻝㻝㻢㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊䜰䝹䝪䞊䝇ദ᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䝉䝭䝘䞊㻌 ᮾி㒔୰ኸ༊
㻞㻜㻜㻤 ᖺ 㻥 ᭶ 㻠 ᪥㻌
䠆㼇㻝㻝㻣㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛻䛴䛔䛶䠊㓇⏣ᕷദ㫽䜲䞁䝣䝹䜶䞁䝄䛻䛛䛛䜛᭱᪂ሗ䛸Ώ䜚㫽䛻䛴䛔䛶䛾ຮᙉ
㓇⏣ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻥 ᭶ 㻟 ᪥㻌
䠆㼇㻝㻝㻤㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊ឡ▱༤グᛕ⅏ᐖ䞉ᩆᛴ་⒪◊✲ദ➨䠏ᅇᅜ㝿⅏㻌
−31−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
ᐖ䞉ᩆᛴ་⒪䝅䞁䝫䝆䜴䝮㻌 ྡྂᒇᕷ㻌 㻞㻜㻜㻤 ᖺ 㻤 ᭶ 㻞㻤 ᪥㻌
䠆㼇㻝㻝㻥㼉ᵳබ୍䠖᪂⣲ᮦ䝗䝻䝬䜲䝖䛾᭷ຠᛶ䠊㻵㻿㻿 ⏘ᴗ⛉Ꮫ䝅䝇䝔䝮䝈ദᢠ䜴䜲䝹䝇䞉ᢠ⳦⣲ᮦ䛾䝯䜹䝙䝈䝮䛸ၟရ㛤Ⓨ
䛻㛵䛩䜛䝉䝭䝘䞊㻌 ᮾி㒔༓௦⏣༊㻌 㻞㻜㻜㻤 ᖺ 㻤 ᭶ 㻝㻥 ᪥㻌
䠆㼇㻝㻞㻜㼉ᵳබ୍䠖㧗ཎᛶ㫽䜲䞁䝣䝹䜶䞁䝄➼䛻䛴䛔䛶䠊ி㒔ᗓദᖹᡂ 㻞㻜 ᖺᗘே䛸ື≀ඹ㏻ឤᰁண㜵ᑐ⟇㐃⤡ㄪ
ᩚ㆟㻌 ≉ูㅮ₇㻌 ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻣 ᭶ 㻞㻞 ᪥㻌
䠆㼇㻝㻞㻝㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄䛛䜙᪂ᆺ䜲䞁䝣䝹䜶䞁䝄䜈䠊㭜◊✲୕㔜┴ᨭ㒊ᢏ⾡◊ಟ㻌 ὠᕷ㻌 㻞㻜㻜㻤 ᖺ 㻣 ᭶ 㻥
᪥㻌
䠆㼇㻝㻞㻞㼉ᵳබ୍䠖㫽䜲䞁䝣䝹䜶䞁䝄ఏ䛻䛴䛔䛶䠊ி㒔ᗓദཎ⏕≀䛸ே㛫䛾┦స⏝⎔䛻㛵䛩䜛ᅜ㝿䝅䞁䝫䝆䜴䝮㻌
ி㒔ᕷ㻌 㻞㻜㻜㻤 ᖺ 㻢 ᭶ 㻝㻝 ᪥䡚㻢 ᭶ 㻝㻟 ᪥㻌
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⣽㔝㻌
䠆㼇㻝㻞㻟㼉◊✲㞟䛂㫽䜲䞁䝣䝹䜶䞁䝄䜢୰ᚰ䛸䛩䜛ឤᰁ䛾ᩘ⌮䇶䝰䝕䝸䞁䜾䛸ゎᯒ䛃䠎䠌䠌䠕ᖺ䠎᭶䠎䠍᪥䇶䠎᭶䠎䠎᪥䠈ி㒔⏘
ᴗᏛ䠄ୡヰே䠖⣽㔝㞝୕䠈➉ෆᗣ༤䠅䜢㛤ദ䛧䚸ឤᰁᩘ⌮䝰䝕䝹◊✲䛾⌧≧䛸ㄢ㢟䜢᳨ウ䛧䛯㻌
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ᕝᮏ㻌
䝔䞊䝬䛂ឤᰁ䛸ேᶒ䛃㻌
䠆㼇㻝㻞㻠㼉ᕝᮏဴ㑻䠖ி㒔ᗓᒣᇛᗈᇦ⯆ᒁேᶒၥ㢟⫋ሙ◊ಟ䠊䠎䠌䠍䠌ᖺ䠎᭶䠍䠒᪥㻌
䠆㼇㻝㻞㻡㼉ᕝᮏဴ㑻䠖⛉◊ᇶ┙◊✲䠄㻮䠅䛂䠎䠍ୡ⣖බ⾗⾨⏕ἲ䝅䝇䝔䝮䛾බἲᏛⓗᐇドⓗ◊✲䛃㻌 䠖ྠᚿ♫Ꮫ䠊䠎䠌䠍䠌㻌
ᖺ䠍᭶䠍䠌᪥㻌
䠆㼇㻝㻞㻢㼉ᕝᮏဴ㑻䠖ி㒔ᗓᒣᇛᗈᇦ⯆ᒁேᶒၥ㢟⫋ሙ◊ಟ䠊䠎䠌䠌䠕ᖺ䠍䠎᭶䠍䠐᪥㻌
䠆㼇㻝㻞㻣㼉ᕝᮏဴ㑻䠖ி㒔ᕷឤᰁデᰝ༠㆟䠄⤖᰾㒊䠅◊✲䠊䠎䠌䠌䠕ᖺ䠏᭶䠍䠌᪥㻌
䝔䞊䝬䛂䜲䞁䝣䜷䞊䝮䝗䞉䝁䞁䝉䞁䝖䛃㻌
䠆㼇㻝㻞㻤㼉ᕝᮏဴ㑻䠖䛂䜲䞁䝣䜷䞊䝮䝗䞉䝁䞁䝉䞁䝖㻌 䠉ἲᚊᏛ䛾❧ሙ䛛䜙䠉䛃㫽ྲྀᏛ㎰Ꮫ㒊㻌 䜲䞁䝣䜷䞊䝮䝗䝁䞁䝉䞁䝖◊ಟ㻌
䠊䠎䠌䠍䠌ᖺ䠔᭶䠍䠌᪥㻌
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−32−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䝅䞁䝫䝆䜴䝮䞉Ꮫ➼䛾ᐇ≧ἣ䚸䜲䞁䝍䞊䝛䝑䝖䛷䛾බ㛤≧ἣ➼㻌
䈜䝩䞊䝮䝨䞊䝆䛷බ㛤䛧䛶䛔䜛ሙྜ䛻䛿䚸㼁㻾㻸 䜢グ㍕䛧䛶䛟䛰䛥䛔䚹㻌
䠘᪤䛻ᐇ䛧䛶䛔䜛䜒䛾䠚㻌
㻌
㻌 ヱᙜ࡞ࡋ
㻌
㻌
㻌
㻌
䠘䛣䜜䛛䜙ᐇ䛩䜛ணᐃ䛾䜒䛾䠚㻌
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㻌 㸰㸮㸯㸱ᖺ㸱᭶ࡣࠊእ㒊ࡽࡢᑓ㛛ᐙࢆᣍࡁࠊྠᮏ◊✲ࣉࣟࢪ࢙ࢡࢺᵓᡂဨࡢྜྠ◊✲
ᡂᯝⓎ⾲ࢆ㛤ദࡍࡿணᐃࢆ❧࡚࡚࠸ࡿࠋ✚ᴟⓗ࡞◊✲ࢆᢲࡋ㐍ࡵࠊ♫⛉Ꮫ᪉㠃ࡽᮏ◊✲ࣉࣟ
ࢪ࢙ࢡࢺ㐍ᒎ㧗࠸㈉⊩ࢆ♧ࡉࢀࡓࠊᕝᮏᩍᤵࢆ୰ᚰࡋࡓࢩ࣏ࣥࢪ࣒࢘ࡋࡓ࠸ࠋࢩ࣏ࣥࢪ࣒࢘
࡛ࡾ࠶ࡆࡿㄢ㢟ࡣࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢⓎ⏕ண ேᶒ㓄៖ࡋࡓ㜵ᑐ⟇ࡢ☜❧࡞ࡿࠋ
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−33−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠍䠐㻌 䛭䛾䛾◊✲ᡂᯝ➼㻌
䛂䠍䠏㻌 ◊✲Ⓨ⾲䛾≧ἣ䛃䛷グ㏙䛧䛯ㄽᩥ䚸ᏛⓎ⾲➼௨እ䛾◊✲ᡂᯝ䚸ᴗ䛸䛾㐃ᦠᐇ⦼䛜䛒䜜䜀ලయⓗ䛻
グධ䛧䛶䛟䛰䛥䛔䚹䜎䛯䚸ୖグ䚸䠍䠍㻔䠐㻕䛻グ㍕䛧䛯◊✲ᡂᯝ䛻ᑐᛂ䛩䜛䜒䛾䛻䛿ୗ⥺ཬ䜃䠆䜢䛧䛶䛟䛰䛥䛔䚹㻌
䈜㻌 ㄽᩥ䜔ᏛⓎ⾲➼䛻䛺䛨䜎䛺䛔◊✲䛷䛒䜛ሙྜ䛿䚸ᮏḍ䜢ᐇ䛥䛫䜛䛣䛸㻌
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⣽㔝㻌
ி㒔Ꮫᩘ⌮ゎᯒ◊✲ᡤ◊✲㞟ࠕ➨㸳ᅇ⏕≀ᩘᏛࡢ⌮ㄽࡑࡢᛂ⏝ࠖ㸪㸰㸮㸮㸷ᖺ㸯᭶㸯㸱᪥̾㸯
᭶㸯㸴᪥㸦◊✲௦⾲⪅㸸⣽㔝㞝୕ࠊ◊✲௦⾲⪅㸸ⱝ㔝୍㑻ࠊ᪥ᮏᩘ⌮⏕≀Ꮫᚋ㸧ࢆ㛤ദ㸬
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ᕝᮏ㻌
᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇᭷㆑⪅㆟㸦➨ ᅇ㸧
ᖺ ᭶ ᪥ ศ㸫 ศ
㸸ෆ㛶⥲⌮⮧ᐁ㑰
㸨ࡑࡢᚋࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇᭷㆑⪅㆟ࡢᵓᡂဨᑵ௵㸦௵ᮇࡣ ᖺ ᭶ ᪥ࡲ࡛㸧
ཧ㆟㝔 ෆ㛶ጤဨ ཧ⪃ே
ࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇≉ูᥐ⨨ἲࡘ࠸࡚ࠖ
ᖺ ᭶ ᪥
㸨ෆᐜࡣ➨ ᅇᅜཧ㆟㝔ෆ㛶ጤဨ㆟㘓 ྕᥖ㍕
タཧほࣥࢱࣅ࣮ࣗ
ᖺ ᭶ ᪥ Ἀ⦖┴⚟♴ಖ㒊ᗣቑ㐍ㄢ
᪥ ⌰⌫㝔
᪥ Ἀ⦖ฮົᡤ
≉ูㅮ₇
ࢸ࣮࣐ࠕឤᰁேᶒࠖ
ᖺ ᭶ ᪥
㫽ྲྀᏛ ➨ 2 ᅇࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺ◊ಟㅮᖌ
ࢸ࣮࣐ࠕ⋇་⒪ッゴࢆᮍ↛㜵ࡄࡓࡵࠖ
㸸㫽ྲྀᏛ㎰Ꮫ㒊
ᖺ ᭶ ᪥≉ูㅮ₇ࠕࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺࠖ
ࠕࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺ 㸫ἲᚊᏛࡢ❧ሙࡽ㸫ࠖ
㫽ྲྀᏛ㎰Ꮫ㒊 ࣥࣇ࢛࣮࣒ࢻࢥࣥࢭࣥࢺ◊ಟ
᭶ ᪥ ி㒔ᗓᒣᇛᗈᇦ⯆ᒁேᶒၥ㢟⫋ሙ◊ಟ
᭶ ᪥ ⛉Ꮫ◊✲㈝⿵ຓ㔠ᇶ┙◊✲㸦%㸧
ࠕ㸰㸯ୡ⣖බ⾗⾨⏕ἲࢩࢫࢸ࣒ࡢබἲᏛⓗᐇドⓗ◊✲ࠖ 㸸ྠᚿ♫Ꮫ
ᖺ ᭶ ᪥ ி㒔ᗓᒣᇛᗈᇦ⯆ᒁேᶒၥ㢟⫋ሙ◊ಟ
᭶ ᪥ ி㒔ᕷឤᰁデᰝ༠㆟㸦⤖᰾㒊㸧◊✲
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୰⏣㻌
㻌 ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᶵᵓࡘ࠸࡚ࡣࠊᮥᯘ〇⸆ᰴᘧ♫ࡢඹྠ◊✲࡛Ᏺ⛎⩏ົ
ࡀ࠶ࡿࡓࡵࠊㄽᩥⓎ⾲࠶ࡿ࠸ࡣᏛⓎ⾲ࢆ᥍࠼࡚࠸ࡿࠋᮏ◊✲㛵㐃ࡋࡓ࣒ࢳࣥ࠾ࡼࡧࣞࢡࢳࣥ㸦ࢩ
ࢢࣞࢵࢡ㸧ࡢ◊✲ࡀࡓࡿⓎ⾲࡞ࡗ࡚࠸ࡿࠋ㛵㐃ࡋ࡚ࠊ௨ୗࡢ≉チ⏦ㄳࢆ⾜ࡗࡓࠋ
≉㛤 ≉㢪 㻌
−34−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
S0801062
䠍䠑㻌 䛂㑅ᐃ䛃ཬ䜃䛂୰㛫ホ౯䛃䛻䛥䜜䛯␃ព㡯䛸䛭䜜䜈䛾ᑐᛂ㻌
䠘䛂㑅ᐃ䛃䛻䛥䜜䛯␃ព㡯䠚㻌
␃ព㡯䛜䛥䜜䛶䛔䛺䛔ሙྜ䛿䛂ヱᙜ䛺䛧䛃䛸グ㍕䛧䛶䛟䛰䛥䛔䚹㻌
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⮬↛⛉Ꮫ♫⛉Ꮫ⼥ྜ࠶ࡿࡀࠊࢇࡀ⌮Ꮫ㒊ᩍဨ࡛࠶ࡾࠊタഛ㈝ࡣ⌮⛉⣔⨨࡛࠶ࡿࠋ♫
ⓗ༴ᶵ⟶⌮ࠊἲᨻ⟇㛵ࡍࡿ⤌⧊యไ࣭ෆᐜࡀ⬤ᙅ࡛࠶ࡿࠋ␗ศ㔝ࡢ㐃ᦠ࡞ࡢ࡛ࠊ㐠Ⴀ㸭ホ౯ࢩ
ࢫࢸ࣒ࡀ࠶ࡿⰋ࠸ࠋ
࡞࠾ࠊ୰㛫ホ౯࠾࠸࡚ࠊ㐍ᤖࡀࡳࡽࢀ࡞࠸ሙྜࡣࠊ⿵ຓ㔠ࡢῶ㢠ཪࡣ⿵ຓࢆᡴࡕษࡿࡇࡀ
࠶ࡿࡢ࡛␃ពࡉࢀࡓ࠸ࠋ
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䠘䛂㑅ᐃ䛃䛻䛥䜜䛯␃ព㡯䜈䛾ᑐᛂ䠚㻌
䛥䜜䛯␃ព㡯䛻ᑐ䛧䚸䛹䛾䜘䛖䛺ᑐᛂ⟇䜢ㅮ䛨䚸䜎䛯䚸䛭䜜䛻䜘䜚䚸䛹䛾䜘䛖䛺ᡂᯝ䛜䛒䛜䛳䛯䛛➼䛻䛴䛔
䛶䚸ヲ⣽䛻グ㍕䛧䛶䛟䛰䛥䛔䚹㻌
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᪂ᆺࣥࣇ࢚ࣝࣥࢨ㜵ᑐ⟇☜❧ࡢࡓࡵࠊ⮬↛⛉Ꮫ㒊㛛♫⛉Ꮫ㒊㛛ࡀᐇ㉁ⓗ⼥ྜࡋ࡚ࠊ
ࡼࡾ㧗ᗘ࡞◊✲ᡂᯝࢆ࠶ࡆࡿࡓࡵࡢ◊✲ᐇຊࢆὀ࠸࡛࠸ࡿࠋࡑࡢຠᯝࡣฟࡘࡘ࠶ࡿࠋ⌧ᐇࠊ
◊✲௦⾲⪅࡛࠶ࡿᵳᖹᡂ ᖺᗘࡲ࡛♫⛉Ꮫ㒊㛛ࢆᢸᙜࡋ࡚࠸ࡓᕝᮏᩍᤵࡣࠊ㗦ពᮏ◊✲ࣉ
ࣟࢪ࢙ࢡࢺࡽᚓࡽࢀ࡚࠸ࡿ◊✲ᡂᯝࢆྫྷࡋ࡚ウㄽࢆ㔜ࡡࠊ⮬↛ྛ㡿ᇦ࡛ᚓࡽࢀࡓ◊✲ᡂᯝ♫
⛉Ꮫ㒊㛛࡛ࡢ⼥ྜ◊✲࡛ᫎࡁࡓࠋࡇࢀࡽ◊✲ᡂᯝࢆࡶࠊᕝᮏᩍᤵࡣࠊྠᚿ♫ᏛᏛ㝔
㌿⫋ࡋࡓ┤ᚋࡢ 2012 ᖺ 4 ᭶ 12 ᪥㛤ദࡉࢀࡓ➨ 180 ᅇᅜཧ㆟㝔ෆ㛶ጤဨཧ⪃ேࡋ࡚
ᣍ⪸ࡉࢀࠊࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇≉ูᥐ⨨ἲࠖᡂ❧㔜せ࡞ᙺࢆᯝࡓࡍࡇࡀ࡛ࡁࡓࠋ
ࡑࡢᚋࠊ2012 ᖺ 8 ᭶ 7 ᪥ࠊᨻᗓࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇᭷㆑⪅㆟ᵓᡂဨᑵ௵ࡋࡓ㸦௵ᮇ
ࡣ 2014 ᖺ 8 ᭶ 6 ᪥ࡲ࡛㸧ࠋ
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䠘䛂୰㛫ホ౯䛃䛻䛥䜜䛯␃ព㡯䠚㻌
␃ព㡯䛜䛥䜜䛶䛔䛺䛔ሙྜ䛿䛂ヱᙜ䛺䛧䛃䛸グ㍕䛧䛶䛟䛰䛥䛔䚹㻌
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␃ព㡯࡛࠶ࡿ␗ศ㔝㐃ᦠࡢᑐᛂࡣ༑ศࡣ࠸࠼࡞࠸ࠋ
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢฟ⌧ឤᰁ࣓࢝ࢽࢬ࣒㛵ࡍࡿ◊✲ࡋ࡚ࡣከࡃࡢᡂᯝࡀ⏕ࡲࢀ࡚
࠸ࡿࠋࡲࡓᚓࡽࢀࡿ▱ぢࡀࣥࣇ࢚ࣝࣥࢨᑐ⟇ࡢၨⵚάື⏕ࡉࢀ࡚࠸ࡿࡇࡣホ౯࡛ࡁࡿࠋࡓ
ࡔࡋࠊ♫༴ᶵ⟶⌮ࡢどⅬࡽヨࡳࡽࢀ࡚࠸ࡿ♫⛉Ꮫศ㔝ࡢ⼥ྜ◊✲ࡋ࡚ࡣࡲࡔ༑ศ࡞ᡂᯝ
⤖ࡧࡘ࠸࡚࠸࡞࠸ࠋ㐃ᦠయไࡢᙉࡀᚲせᛮࢃࢀࡿࠋ
䠘䛂୰㛫ホ౯䛃䛻䛥䜜䛯␃ព㡯䜈䛾ᑐᛂ䠚㻌
䛥䜜䛯␃ព㡯䛻ᑐ䛧䚸䛹䛾䜘䛖䛺ᑐᛂ⟇䜢ㅮ䛨䚸䜎䛯䚸䛭䜜䛻䜘䜚䚸䛹䛾䜘䛖䛺ᡂᯝ䛜䛒䛜䛳䛯䛛➼䛻䛴䛔
䛶䚸ヲ⣽䛻グ㍕䛧䛶䛟䛰䛥䛔䚹㻌
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ࠕ♫༴ᶵ⟶⌮ࡢどⅬࡽヨࡳࡽࢀ࡚࠸ࡿ♫⛉Ꮫศ㔝ࡢ⼥ྜ◊✲ࡋ࡚ࡣࡲࡔ༑ศ࡞ᡂᯝ
⤖ࡧࡘ࠸࡚࠾ࡽࡎࠊ㐃ᦠయไࡢᙉࡀᚲせᛮࢃࢀࡿࠋࠖ࠸࠺୰㛫ホ౯ࡢ␃ព㡯ࡀࡉࢀࡓ
ࡓࡵࠊ♫༴ᶵ⟶⌮ࡢどⅬࡽぢࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㜵ᑐ⟇☜❧ࡢࡓࡵࠊ⮬↛⛉Ꮫ㒊㛛࡛ᚓ
ࡽࢀࡓᡂᯝࢆᇶࠊ♫⛉Ꮫ㒊㛛ᢸᙜᩍဨࡢウ㆟ࢆ㗦ព⧞ࡾ㏉ࡋࡓࠋࡍ࡞ࢃࡕࠊ᪂ᆺࣥࣇ࢚ࣝ
ࣥࢨⓎ⏕࠶ࡿ࠸ࡣὶ⾜࠾ࡅࡿᵝࠎ࡞♫༴ᶵ⟶⌮యไࡢ☜❧ྥࡅ࡚ࠊࡼࡾ㧗ᗘ࡛ྜ⌮ⓗ࡞
ᥦࡀ࡞ࡉࢀࡿࡼ࠺㐃ᦠࢆᙉࡋࡓࠋࡑࡢᡂᯝࡣᐇࡗࡓࠋ◊✲௦⾲⪅࡛࠶ࡿᵳࢆࡣࡌࡵࠊ⮬↛
⛉Ꮫ㒊㛛ࡢ◊✲ᡂᯝࢆᇶ┙ࡋࡘࡘࠊᖹᡂ ᖺᗘࡲ࡛♫⛉Ꮫ㒊㛛ࡢ୰᰾ࢆᢸࡗ࡚ࡁࡓᕝᮏ㸦ᩍ
ᤵ㸧ࡼࡾࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㛵ࡍࡿㄽᩥࡀ ሗ㸦㞧ㄅㄽᩥ 㹼 ཧ↷㸧ࢆබ⾲ࡍࡿࡇ࡛ࠊ
♫༴ᶵ⟶⌮యไࡢᅾࡾ᪉ࡘ࠸࡚ᥦࡍࡿ࡞ࡢᐇ⦼ࢆᣲࡆࡿࡇࡀ࡛ࡁࡓࠋࡲࡓࠊᕝᮏࡢ㌿ฟ
ᚋࡢᴗ⦼ࡋ࡚ࡣࠊ๓㏙ࡢ࠾ࡾ࡛ᮏࣉࣟࢪ࢙ࢡࢺࢆᇶ┙ࡋࡓᡂᯝࢆᣲࡆ࡚࠸ࡿࠋ
−35−
䠄ᵝᘧ䠍䠅
㻿㻜㻤㻜㻝㻜㻢㻞
䝥䝻䝆䜵䜽䝖␒ྕ
䠍䠒䚷タ䞉⨨䞉タഛ䞉◊✲㈝䛾ᨭฟ≧ἣ䠄ᐇ⦼ᴫせ䠅
ෆ䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷ヂ
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䈜䚷᭱⤊ᖺᗘ䛿ணᐃ㢠䚹
−36−
ഛ䚷⪃
㻶㻿㼀㻞௳䚸㻺㻱㻰㻻䚸⤒⏘┬䚸
㻜 ㎰Ỉ┬ᴗ䚸Ẹ㛫㻝㻠௳
㻶㻿㼀㻞௳䚸㻺㻱㻰㻻䚸⤒⏘┬䚸
㻜 ㎰Ỉ┬ᴗ䚸Ẹ㛫㻝㻥௳
㻶㻿㼀㻞௳䚸㻺㻱㻰㻻䚸㻶㻭㼄㻭䚸ᮾᾏᏛ䚸
㜰ᕷ❧Ꮫ䚸Ẹ㛫㻝㻜௳
㻜 㻶㻿㼀䚸⤒⏘┬䚸Ẹ㛫㻤௳
㻶㻿㼀䚸㎰Ỉ┬䚸⤒⏘┬䚸ி㒔ᕷ䚸㜰
ᕷ❧Ꮫ䚸Ẹ㛫㻞௳
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
㻿㻜㻤㻜㻝㻜㻢㻞
䠍䠓䚷タ䞉⨨䞉タഛ䛾ᩚഛ≧ἣ㻌㻌䠄⚾Ꮫຓᡂ䜢ཷ䛡䛯䜒䛾䛿䛩䜉䛶グ㍕䛧䛶䛟䛰䛥䛔䚹䠅
䛀䚷䚷タ䛁㻌㻌䠄⚾Ꮫຓᡂ䜢ཷ䛡䛶䛔䛺䛔䜒䛾䜒ྵ䜑䚸⏝䛧䛶䛔䜛タ䜢䛩䜉䛶グ㍕䛧䛶䛟䛰䛥䛔䚹䠅
䚷タ䚷䛾䚷ྡ䚷⛠
ᩚഛᖺᗘ
㻢㻞ᖺ
㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ➨㻞㻝ᐇ㦂◊✲ᐊ 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ䡴䢔䡬䢙䢕䡬䢍㻝 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ䡴䢔䡬䢙䢕䡬䢍㻞 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ➨㻝㻝ᐇ㦂◊✲ᐊ 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷศᏊ⣽⬊ᕤᏛᐇ㦂◊✲ᐊ 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻞䛇➨㻞ᐇ㦂ᐊᲷ㻢㻣◊✲ᐊ ᖹᡂඖᖺ
䛆㻴㻞㻜䡚㻞㻞䛇➨㻞ᐇ㦂ᐊᲷ㻢㻢ᐇ㦂‽ഛᐊ ᖹᡂඖᖺ
䛆㻴㻞㻜䡚㻞㻠䛇㻠ྕ㤋㻝㻝㻥◊✲ᐊ 㻠㻞ᖺ
䛆㻴㻞㻜䡚㻞㻟䛇➨㻞◊✲ᐊᲷ㻡㻤㻣◊✲ᐊ 㻢㻞ᖺ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ㻟㻞ᐇ㦂ᐊ
䛆㻴㻞㻜䡚㻞㻝䛇➨㻝ᐇ㦂ᐊᲷ➨㻝㻞ᐇ㦂◊✲ᐊ
䛆㻴㻞㻜䡚㻞㻞䛇㫽䡮䢙䢈䢕䡰䢙䡷䢚◊✲䡺䢙䡼䡬㻔
ሗᢏ⾡ᐇ㦂ᐊᲷ䡡㻞㻜㻝㻜㻛㻣㻛㻝㻞䜎䛷䠅
ᖹᡂ㻝㻤ᖺ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻟㻞㻠ᐇ㦂ᐊ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻝㻝㻥◊✲ᐊ
ᖹᡂ㻞㻞ᖺ
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䛆㻴㻞㻞䡚㻞㻠䛇㫽䡮䢙䢈䢕䡰䢙䡷䢚◊✲䡺䢙䡼䡬㻔㻝㻢
ྕ㤋䞉㻣㻛㻝㻟䛛䜙㻕
ᖹᡂ㻞㻞ᖺ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻮㻞㻣ᐇ㦂ᐊ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻞㻞㻡䡴䢔䡬䢙䢕䡬䢍
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻞㻝㻡ᇵ㣴ᐊ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻝㻞㻠ᐇ㦂ᐊ
䛆㻴㻞㻞䡚㻞㻠䛇㻝㻡ྕ㤋㻝㻡㻝㻝㻢ᩍဨᐇ㦂ᐊ
䛆㻴㻞㻟䡚㻞㻠䛇㻞ྕ㤋㻟㻤◊✲ᐊ 㻠㻞ᖺ
䛆㻴㻞㻟䡚㻞㻠䛇㻞ྕ㤋➨㻢ᐇ㦂ᐊ 㻠㻞ᖺ
䛆㻴㻞㻟䡚㻞㻠䛇㻥ྕ㤋◊✲ᐊ㻰 ᖹᡂ㻡ᖺ
䛆㻴㻞㻟䡚㻞㻠䛇㻥ྕ㤋㻥㻞㻠ᐇ㦂◊✲ᐊ
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㻜
䟝
䛀⨨䞉タഛ䛁䚷䠄⚾Ꮫຓᡂ䜢ཷ䛡䛶䛔䛺䛔䜒䛾䛿䚸䛺䜒䛾䛾䜏䜢グ㍕䛧䛶䛟䛰䛥䛔䚹䠅
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㻞㻟㻢
㻥㻥㻞
㟁ẼὋື䡼䢙䢆䢛䡴㉁㌿⨨ ᖹᡂ㻞㻞ᖺ 㼀㻾㻭㻺㻿㻲㻱㻾㻌㼁㻺㻵㼀㻘㻞㻝㼄㻞㻢㻯㻹
㻝ྎ
㻠㻤
䡄
㻞㻟㻥
䝰䝕䝹㻠㻥㻝䝥䝺䝑䝥䝉䝹 ᖹᡂ㻞㻟ᖺ 䝇䝍䞊䝍䞊䜻䝑䝖
䡸䢙䡴䢚䢕䡽䡩䡬䢈䢚䢕䢌䢅䢎䡬䡼䡬 ᖹᡂ㻞㻟ᖺ 㻸㼡㼙㼍㼠㻌㻸㻮㻥㻡㻜㻣
⸆⏝ಖ෭ᗜ
ᖹᡂ㻞㻟ᖺ 㻹㻼㻾㻙㻠㻝㻠㻲㻾
䜲䞁䜻䝳䝧䞊䝍䞊㻔෭ᶵ䠅 ᖹᡂ㻞㻟ᖺ 㻹㻵㻾㻙㻞㻡㻠
ᚤ㔞㧗㏿෭༷㐲ᚰᶵ ᖹᡂ㻞㻟ᖺ 㻹㻵㼄㻙㻟㻜㻡
㉸㧗⢭⣽䡲䢓䡬෭༷䡲䢎䢓䢉䡫䢀䢚୍ᘧ ᖹᡂ㻞㻠ᖺ 㻰㻿㻙㻾㼕㻝㻙㼁㻟
㻝ᘧ
㻝ᘧ
㻝ྎ
㻝ྎ
㻝ྎ
㻝ᘧ
㻝㻟㻡
㻠㻜
㻤㻘㻣㻢㻜
㻤㻘㻣㻢㻜
㻞㻜㻜
㻞㻜
䡄
䡄
䡄
䡄
䡄
䡄
㻣㻠㻢
㻞㻘㻜㻣㻥
㻠㻞㻞
㻠㻤㻥
㻝㻘㻝㻟㻡
㻝㻘㻞㻣㻝
㻝ᘧ
㻞㻘㻤㻜㻜
䡄
䡄
䡄
㻡㻢㻤
ඹ↔Ⅼ㢧ᚤ㙾㻿㻼㻱
㐲ᚰ⨨୍ᘧ
ᖹᡂ㻞㻜ᖺ 㻰㻹㻡㻡㻜㻜㻮㻌㼂㻙㼂㻵㻿㻌㻟㻰䡺䡫䢀
ᖹᡂ㻞㻝ᖺ 㻯㻿㻝㻡㻜㻳㼄䊡
㧗㏿ᐜ㔞෭༷㐲ᚰᶵ୍ᘧ ᖹᡂ㻞㻞ᖺ 䠓㻣㻤㻜䊡
䜸䞊䝖䜽䝺䞊䝤
ᖹᡂ㻞㻞ᖺ 㻸㻿㼄㻙㻣㻜㻜
ᖹᡂ㻞㻞ᖺ 㻹㻼㻾㻙㻞㻝㻠㻲
ಖ෭ᗜ䠄⣙㻝㻞㻜㻸䠅
㑇ఏᏊᑟධ⨨
ᖹᡂ㻞㻞ᖺ 㻹㻾㻷㻡㻜㻜㻜㻿
㼀㻱㻌㻣㻣㻌㻼㼃㻾㻌㻿㻱㻹㻵㻙㻰㻾㼅
䠄ሗฎ⌮㛵ಀタഛ䠅
䝽䞊䜽䝇䝔䞊䝅䝵䞁୍ᘧ ᖹᡂ㻞㻞ᖺ 㻸㼑㼚㼛㼢㼛㼀㼔㼕㼚㼗㻿㼠㼍㼠㼕㼛㼚㻿㻞㻜
−37−
㻝㻤㻘㻞㻜㻟 ⚾Ꮫຓᡂ
㻠㻘㻣㻥㻡 ⚾Ꮫຓᡂ
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
ᖺ䚷䚷䚷ᗘ
ᑠ㻌㻌⛉㻌㻌┠
ᩍ⫱◊✲⏝ᶵჾഛရ
ᅗ䚷䚷䚷䚷᭩
ィ
䝸䝃䞊䝏䞉䜰䝅䝇䝍䞁䝖
䝫䝇䝖䞉䝗䜽䝍䞊
◊✲ᨭ᥎㐍⤒㈝
ィ
ᖺ䚷䚷䚷ᗘ
ᑠ㻌㻌⛉㻌㻌┠
ᾘ䚷⪖䚷ရ䚷㈝
ග䚷⇕䚷Ỉ䚷㈝
㏻ಙ㐠ᦙ㈝
༳ๅ〇ᮏ㈝
᪑㈝㏻㈝
ሗ㓘䞉ጤクᩱ
䠄ㅖ㈝䞉ฟ∧≀㈝䞉㈤ᩱ䠅
ィ
ே௳㈝ᨭฟ
䠄වົ⫋ဨ䠅
ᩍ⫱◊✲⤒㈝ᨭฟ
ィ
ᩍ⫱◊✲⏝ᶵჾഛရ
ᅗ䚷䚷䚷䚷᭩
ィ
䝸䝃䞊䝏䞉䜰䝅䝇䝍䞁䝖
䝫䝇䝖䞉䝗䜽䝍䞊
◊✲ᨭ᥎㐍⤒㈝
ィ
㻿㻜㻤㻜㻝㻜㻢㻞
ᖺᗘ
✚䚷䚷⟬䚷䚷ෆ䚷䚷ヂ
㔠䚷䚷㢠
䚷䚷䛺䚷䚷ෆ䚷䚷ᐜ
䚷䛺䚷䚷㏵
ᩍ䚷䚷䚷䚷⫱䚷䚷䚷䚷◊䚷䚷䚷䚷✲䚷䚷䚷䚷⤒䚷䚷䚷䚷㈝䚷䚷䚷䚷ᨭ䚷䚷䚷䚷ฟ
㻝㻝㻘㻡㻢㻤 䡯䡮䢕䡹ཷᐜయ⢭〇䚸䡯䡮䢕䡹ቑṪ➼㻔㻝㻝㻘㻡㻢㻤㻕
㻝㻝㻘㻡㻢㻤 ヨ⸆㢮䚸㻿㻼㻲㭜༸➼
㻜
㻜
㻜
㻜
㻜
㻜
㻜
㻜
㻢㻟 ᴗົጤク㈝
㻢㻟 ᴗົጤク㈝㻔㻢㻟㻕
㻣㻞 ᭩⡠㉎ධ㈝㻔㻣㻞㻕
㻣㻞 ฟ∧≀㈝
㻝㻝㻘㻣㻜㻟
䜰䚷䚷䚷䝹䚷䚷䚷䝞䚷䚷䚷䜲䚷䚷䚷䝖䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻜
㻜
ᨭ䚷ฟ䚷㢠
ᾘ䚷⪖䚷ရ䚷㈝
ග䚷⇕䚷Ỉ䚷㈝
㏻ಙ㐠ᦙ㈝
༳ๅ〇ᮏ㈝
᪑㈝㏻㈝
ሗ㓘䞉ጤクᩱ
䠄䚷ฟ∧≀㈝䚷䠅
ィ
ே௳㈝ᨭฟ
䠄වົ⫋ဨ䠅
ᩍ⫱◊✲⤒㈝ᨭฟ
ィ
㻞㻜
㻌㻌ᖹᡂ
㻜
㻜
㻜
タ㻌ഛ㻌㛵㻌ಀ㻌ᨭ㻌ฟ䠄䠍ಶཪ䛿䠍⤌䛾౯᱁䛜䠑䠌䠌ᮍ‶䛾䜒䛾䠅
㻝㻝㻘㻣㻟㻥 䝍䞁䝟䜽䚸㑇ఏᏊゎᯒ
㻝㻝㻘㻣㻟㻥 䢕䢌䢅䞉䡮䢎䡬䡸䢚䡭䢁䢓䡮䡷䢚䡬㻔㻠㻘㻥㻥㻤㻕䚸䡷䡬䢋䢕䡷䡮䡴䢓䡬㻔㻝㻘㻤㻞㻣㻕
㻜
㻜
㻝㻝㻘㻣㻟㻥
◊䚷䚷䚷✲䚷䚷䚷䝇䚷䚷䚷䝍䚷䚷䚷䝑䚷䚷䚷䝣䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻜
㻜
㻜
㻜
㻜
㻜
㻜
㻞㻝
㻌㻌ᖹᡂ
ᖺᗘ
✚䚷䚷⟬䚷䚷ෆ䚷䚷ヂ
䚷䛺䚷䚷㏵
㔠䚷䚷㢠
䚷䚷䛺䚷䚷ෆ䚷䚷ᐜ
ᩍ䚷䚷䚷䚷⫱䚷䚷䚷䚷◊䚷䚷䚷䚷✲䚷䚷䚷䚷⤒䚷䚷䚷䚷㈝䚷䚷䚷䚷ᨭ䚷䚷䚷䚷ฟ
㻝㻡㻘㻥㻡㻜 ᐇ㦂⏝ヨ⸆㢮
㻝㻡㻘㻥㻡㻜 ヨ⸆㢮㻔㻥㻘㻡㻝㻠㻕䚸ᐇ㦂⏝ჾල㻔㻠㻘㻠㻞㻡㻕
㻜
㻜
㻝 㒑㏦ᩱ
㻝 㒑㏦ᩱ㻔㻝㻕
㻝 ูๅ䞉ㄽᩥᢞ✏
㻝 ูๅ䞉ㄽᩥᢞ✏ᩱ㻔㻝㻕
㻝㻘㻝㻜㻟 ᅜෆእฟᙇ᪑㈝
㻝㻘㻝㻜㻟 ᅜእ᪑㈝㻔㻠㻟㻠㻕䚸ᅜෆ᪑㈝㻔㻢㻢㻥㻕
㻢㻞 ㅰ㔠
㻢㻞 ㅮ₇ㅰ㔠㻔㻢㻞㻕
㻡㻜㻠 ㈤ᩱ䞉Ꮫཧຍ㈝䞉ฟ∧≀㈝
㻡㻜㻠 ㌴୧䢔䡬䡹௦㻔㻟㻣㻜䠅䚸Ꮫཧຍ㈝㻔㻝㻞㻥㻕䚸ฟ∧≀㈝㻔㻡㻕
㻝㻣㻘㻢㻞㻝
䜰䚷䚷䚷䝹䚷䚷䚷䝞䚷䚷䚷䜲䚷䚷䚷䝖䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻜
㻜
ᨭ䚷ฟ䚷㢠
㻜
㻜
㻜
タ㻌ഛ㻌㛵㻌ಀ㻌ᨭ㻌ฟ䠄䠍ಶཪ䛿䠍⤌䛾౯᱁䛜䠑䠌䠌ᮍ‶䛾䜒䛾䠅
㻤㻘㻤㻥㻥 ᐇ㦂⏝⨨
㻤㻘㻤㻥㻥 䢔䡭䢕䡼䡮䢍㻼㻯㻾䡸䡹䡿䢍㻔㻠㻘㻣㻞㻡㻕䚸䡮䢎䡬䡸䢚䢙䡴䢚䡵䢚䢕ᙳ⨨䢈䢛䢔䢙䢀䡴䢚䢓䢈㻔㻝㻘㻡㻝㻞㻕
㻝㻟㻠 㛵㐃ᅗ᭩㉎ධ
㻝㻟㻠 㛵㐃ᅗ᭩㻔㻝㻟㻠㻕
㻥㻘㻜㻟㻟
◊䚷䚷䚷✲䚷䚷䚷䝇䚷䚷䚷䝍䚷䚷䚷䝑䚷䚷䚷䝣䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻝㻘㻞㻜㻜
㻝㻘㻞㻜㻜 Ꮫෆ㻞ே䚷
㻜
㻜
㻜
㻜
㻝㻘㻞㻜㻜
Ꮫෆ㻞ே䚷
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇ཷᐜయ䜈䛾⤖ྜ䛾㜼ᐖຠᯝ䛾᳨ウ
−38−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
ᖺ䚷䚷䚷ᗘ
ᑠ㻌㻌⛉㻌㻌┠
✚䚷䚷⟬䚷䚷ෆ䚷䚷ヂ
䚷䛺䚷䚷㏵
㔠䚷䚷㢠
䚷䚷䛺䚷䚷ෆ䚷䚷ᐜ
ᩍ䚷䚷䚷䚷⫱䚷䚷䚷䚷◊䚷䚷䚷䚷✲䚷䚷䚷䚷⤒䚷䚷䚷䚷㈝䚷䚷䚷䚷ᨭ䚷䚷䚷䚷ฟ
㻝㻠㻘㻜㻢㻢 ᾘ⪖ရ㈝
㻝㻠㻘㻜㻢㻢 ヨ⸆㻔㻣㻘㻠㻜㻤㻕䚸ᐇ㦂ჾල䚸⏬ീゎᯒ䡻䢈䢀䡯䡦䡭㻔㻞㻜㻕
㻜
㻜
㻜
㻜
㻜
㻜
㻟㻘㻞㻥㻤 ᅜෆእฟᙇ᪑㈝
㻟㻘㻞㻥㻤 ᅜእ᪑㈝㻔㻞㻘㻜㻡㻟㻕䚸ᅜෆ᪑㈝㻔㻝㻘㻞㻠㻡㻕
㻢㻥 ㅰ㔠䞉ᴗົጤク㈝
㻢㻥 ㅰ㔠㻔㻢㻜㻕䚸ᴗົጤク㈝㻔㻥㻕
㻡㻝㻡 ㈤ᩱ䞉Ꮫཧຍ㈝
㻡㻝㻡 ㈤ᩱ㻔㻝㻞㻢㻕䚸Ꮫཧຍ㈝㻔㻟㻜㻟㻕䚸ฟ∧≀㈝㻔㻝㻥㻕
㻝㻣㻘㻥㻠㻤
䜰䚷䚷䚷䝹䚷䚷䚷䝞䚷䚷䚷䜲䚷䚷䚷䝖䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻝㻠㻣 䜰䝹䝞䜲䝖௦
㻝㻠㻣 ⤥㻝㻘㻞㻜㻜㻘ᖺ㛫㛫ᩘ㻤㻠㛫
䠄㈤ᩱ䞉ㅖ㈝䞉ฟ∧≀㈝䞉බ⛒බㄢ䞉㞧㈝䠅
ィ
ே௳㈝ᨭฟ
䠄වົ⫋ဨ䠅
ᩍ⫱◊✲⤒㈝ᨭฟ
ィ
⤥㻝㻘㻠㻡㻜㻘ᖺ㛫㛫ᩘ㻟㻞㛫㻌ᐇேᩘ㻠ே
㻜
㻜
㻝㻠㻣
タ㻌ഛ㻌㛵㻌ಀ㻌ᨭ㻌ฟ䠄䠍ಶཪ䛿䠍⤌䛾౯᱁䛜䠑䠌䠌ᮍ‶䛾䜒䛾䠅
㻣㻘㻠㻝㻣 ᶵჾഛရ
㻝㻘㻠㻝㻣 㧗㏿ᐜ㔞෭༷㐲ᚰᶵ୍ᘧ㻔㻠㻘㻝㻤㻣㻕䚸䡱䡬䢀䡴䢖䡬䢈䢚㻔㻝㻘㻝㻥㻡㻕
㻝㻢㻣 㛵㐃ᅗ᭩㉎ධ
㻝㻢㻣 㛵㐃ᅗ᭩㻔㻝㻢㻣㻕
㻣㻘㻡㻤㻠
◊䚷䚷䚷✲䚷䚷䚷䝇䚷䚷䚷䝍䚷䚷䚷䝑䚷䚷䚷䝣䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻢㻜㻜
㻢㻜㻜 Ꮫෆ㻞ே
㻜
㻜
㻜
㻜
㻢㻜㻜
Ꮫෆ㻞ே
ᩍ⫱◊✲⏝ᶵჾഛရ
ᅗ䚷䚷䚷䚷᭩
ィ
䝸䝃䞊䝏䞉䜰䝅䝇䝍䞁䝖
䝫䝇䝖䞉䝗䜽䝍䞊
◊✲ᨭ᥎㐍⤒㈝
䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇ཷᐜయ䜈䛾⤖ྜ䛾㜼ᐖຠᯝ䛾᳨ウ
ィ
ᑠ㻌㻌⛉㻌㻌┠
ᾘ䚷⪖䚷ရ䚷㈝
ග䚷⇕䚷Ỉ䚷㈝
㏻ಙ㐠ᦙ㈝
༳ๅ〇ᮏ㈝
᪑㈝㏻㈝
㈤䚷䚷ᩱ
ሗ㓘䞉ጤクᩱ
䠄Ꮫཧຍ㈝䞉Ꮫᖺ㈝䠅
䠄ฟ∧≀䞉ᨭᡶᡭᩘᩱ䞉㌴୧⇞ᩱ㈝䞉䛭䛾䛾
ಖ㝤ᩱ䞉බ⛒බㄢ䠅
ィ
ே௳㈝ᨭฟ
䠄වົ⫋ဨ䠅
ᩍ⫱◊✲⤒㈝ᨭฟ
ィ
ᩍ⫱◊✲⏝ᶵჾഛရ
ᅗ䚷䚷䚷䚷᭩
ィ
䝸䝃䞊䝏䞉䜰䝅䝇䝍䞁䝖
䝫䝇䝖䞉䝗䜽䝍䞊
◊✲ᨭ᥎㐍⤒㈝
ィ
ᖺᗘ
ᨭ䚷ฟ䚷㢠
ᾘ䚷⪖䚷ရ䚷㈝
ග䚷⇕䚷Ỉ䚷㈝
㏻ಙ㐠ᦙ㈝
༳ๅ〇ᮏ㈝
᪑㈝㏻㈝
ሗ㓘䞉ጤクᩱ
ᖺ䚷䚷䚷ᗘ
㻞㻞
㻌㻌ᖹᡂ
㻿㻜㻤㻜㻝㻜㻢㻞
㻞㻟
㻌㻌ᖹᡂ
ᖺᗘ
✚䚷䚷⟬䚷䚷ෆ䚷䚷ヂ
䚷䛺䚷䚷㏵
㔠䚷䚷㢠
䚷䚷䛺䚷䚷ෆ䚷䚷ᐜ
ᩍ䚷䚷䚷䚷⫱䚷䚷䚷䚷◊䚷䚷䚷䚷✲䚷䚷䚷䚷⤒䚷䚷䚷䚷㈝䚷䚷䚷䚷ᨭ䚷䚷䚷䚷ฟ
㻝㻟㻘㻢㻣㻜 ᾘ⪖ရ㈝
㻝㻟㻘㻢㻣㻜 ୍⯡ᾘ⪖ရ㈝䠄㻟㻝㻞䠅䚸䡻䢈䢀䡯䡦䡭䠄㻝㻤䠅୍⯡ヨ⸆䞉ჾල➼䠄㻝㻟㻘㻟㻠㻜䠅
㻜
㻜
㻜
㻜
㻜
㻜
㻠㻘㻝㻝㻡 ᅜෆእฟᙇ᪑㈝
㻠㻘㻝㻝㻡 ᅜእ᪑㈝㻔㻟㻘㻜㻞㻟㻕䚸ᅜෆ᪑㈝㻔㻝㻘㻜㻥㻞㻕
㻝㻤㻢 ㈤ᩱ
㻝㻤㻢 ㈤ᩱ㻔㻝㻤㻢㻕
㻜
㻜
㻠㻥㻣 Ꮫཧຍ㈝
㻠㻥㻣 Ꮫཧຍ㈝㻔㻠㻣㻣㻕䞉Ꮫᖺ㈝㻔㻞㻜㻕
㻝㻜㻜 ฟ∧≀
㻝㻜㻜 ฟ∧≀䠄㻠㻝䠅䞉ᨭᡶᡭᩘᩱ䠄㻝䠅䞉㌴୧⇞ᩱ㈝䠄㻣䠅䞉䛭䛾䛾ಖ㝤ᩱ䠄㻞䠅䞉බ⛒බㄢ䠄㻠㻥䠅
㻝㻤㻘㻡㻢㻤
䜰䚷䚷䚷䝹䚷䚷䚷䝞䚷䚷䚷䜲䚷䚷䚷䝖䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻟㻘㻜㻢㻠 䜰䝹䝞䜲䝖௦
㻟㻘㻜㻢㻠 ⤥㻝㻘㻟㻣㻜㻘ᖺ㛫㛫ᩘ㻝㻘㻞㻢㻡㛫
ᨭ䚷ฟ䚷㢠
⤥㻝㻘㻠㻡㻜㻘ᖺ㛫㛫ᩘ㻥㻝㻤㛫㻌ᐇேᩘ㻟ே
㻜
㻜
㻟㻘㻜㻢㻠
タ㻌ഛ㻌㛵㻌ಀ㻌ᨭ㻌ฟ䠄䠍ಶཪ䛿䠍⤌䛾౯᱁䛜䠑䠌䠌ᮍ‶䛾䜒䛾䠅
㻠㻘㻤㻣㻝 ᶵჾഛရ
㻠㻘㻤㻣㻝 䢕䢌䢅䢎䡬䡼䡬㻔㻞㻘㻜㻣㻥㻕䚸ᚤ㔞㧗㏿෭༷㐲ᚰᶵ㻔㻝㻘㻝㻟㻡㻕
㻞㻤 㛵㐃ᅗ᭩㉎ධ
㻞㻤 㛵㐃ᅗ᭩㻔㻞㻤㻕
㻠㻘㻤㻥㻥
◊䚷䚷䚷✲䚷䚷䚷䝇䚷䚷䚷䝍䚷䚷䚷䝑䚷䚷䚷䝣䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻟㻜㻜
㻟㻜㻜 Ꮫෆ㻝ே䚷
㻜
㻜
㻜
㻜
㻟㻜㻜
Ꮫෆ㻝ே
䝅䜾䝺䝑䜽䝣䜯䝭䝸㻙䛻䜘䜛䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ឤᰁ㜼ᐖຠᯝ䛾᳨ウ
−39−
䠄ᵝᘧ䠍䠅
䝥䝻䝆䜵䜽䝖␒ྕ
ᖺ䚷䚷䚷ᗘ
ᑠ㻌㻌⛉㻌㻌┠
ᾘ䚷⪖䚷ရ䚷㈝
ග䚷⇕䚷Ỉ䚷㈝
㏻ಙ㐠ᦙ㈝
༳ๅ〇ᮏ㈝
᪑㈝㏻㈝
ሗ㓘䞉ጤクᩱ
㻔Ꮫཧຍ㈝䠅
䠄ㄽᩥᢞ✏ᩱ䞉㆟㈝䠅
ィ
ே௳㈝ᨭฟ
䠄වົ⫋ဨ䠅
ᩍ⫱◊✲⤒㈝ᨭฟ
ィ
ᩍ⫱◊✲⏝ᶵჾഛရ
ᅗ䚷䚷䚷䚷᭩
ィ
䝸䝃䞊䝏䞉䜰䝅䝇䝍䞁䝖
䝫䝇䝖䞉䝗䜽䝍䞊
◊✲ᨭ᥎㐍⤒㈝
ィ
㻞㻠
㻌㻌ᖹᡂ
㻿㻜㻤㻜㻝㻜㻢㻞
ᖺᗘ
✚䚷䚷⟬䚷䚷ෆ䚷䚷ヂ
䚷䛺䚷䚷㏵
㔠䚷䚷㢠
䚷䚷䛺䚷䚷ෆ䚷䚷ᐜ
ᩍ䚷䚷䚷䚷⫱䚷䚷䚷䚷◊䚷䚷䚷䚷✲䚷䚷䚷䚷⤒䚷䚷䚷䚷㈝䚷䚷䚷䚷ᨭ䚷䚷䚷䚷ฟ
㻝㻝㻘㻟㻠㻠 ୍⯡ᾘ⪖ရ㈝
㻝㻝㻘㻟㻠㻠 ヨ⸆㻔㻣㻘㻡㻤㻠㻕䚸ᐇ㦂ჾල㻔㻝㻘㻜㻞㻣㻕䚸ᶵჾ䠄㻞㻘㻝㻜㻜䠅
㻜
㻜
㻝㻡㻥 㒑㏦ᩱ
㻝㻡㻥 Ꮿᛴ౽㻔㻥㻕䚸㒑㏦ᩱ㻔㻝㻡㻜㻕
㻤㻡㻜
㻤㻡㻜 ◊✲ᡂᯝሗ࿌᭩〇ᮏ㈝䠄㻤㻡㻜䠅
㻟㻘㻥㻞㻜 ᅜෆእฟᙇ᪑㈝
㻟㻘㻥㻞㻜 ᅜእ᪑㈝䠄㻞㻘㻟㻡㻜䠅䚸ᅜෆ᪑㈝䠄㻝㻘㻡㻣㻜䠅
㻠㻡㻜 ㅰ㔠䞉ᴗົጤク㈝
㻠㻡㻜 ㅮ₇ㅰ㔠㻔㻟㻡㻜㻕䚸ㄽᩥⱥᩥᰯṇ㻔㻡㻜㻕䚸ᢠయཬ䜃Ⓨ⌧⣔ᵓ⠏㻔㻡㻜㻕
㻝㻡㻡 Ꮫཧຍ㈝
㻝㻡㻡 Ꮫཧຍ㈝㻔㻝㻡㻡㻕
㻝㻝㻜 ㄽᩥᢞ✏ᩱ䞉㆟㈝
㻝㻝㻜 ㄽᩥᢞ✏ᩱ㻔㻢㻜㻕䚸㆟㈝䠄㻡㻜䠅
㻝㻢㻘㻥㻤㻤
䜰䚷䚷䚷䝹䚷䚷䚷䝞䚷䚷䚷䜲䚷䚷䚷䝖䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻠㻘㻜㻡㻜 䜰䝹䝞䜲䝖௦
㻠㻘㻜㻡㻜 ⤥㻝㻘㻠㻡㻜㻘ᖺ㛫㛫ᩘ㻞㻘㻢㻜㻜㛫
ᨭ䚷ฟ䚷㢠
⤥㻝㻘㻜㻜㻜㻘ᖺ㛫㛫ᩘ㻞㻤㻜㛫㻌ᐇேᩘ㻟ே
㻜
㻜
㻠㻘㻜㻡㻜
タ㻌ഛ㻌㛵㻌ಀ㻌ᨭ㻌ฟ䠄䠍ಶཪ䛿䠍⤌䛾౯᱁䛜䠑䠌䠌ᮍ‶䛾䜒䛾䠅
㻡㻘㻟㻢㻣 ᶵჾഛရ
㻡㻘㻟㻢㻣 ㉸ప 䢈䢔䡬䡷䢚䡬㻔㻝㻘㻢㻡㻥㻕䚸Ᏻ䡳䡨䢇䢚䢄䡫䢀㻔㻞㻘㻜㻥㻢㻕
㻥㻡 㛵㐃ᅗ᭩㉎ධ
㻥㻡 㛵㐃ᅗ᭩㻔㻥㻡㻕
㻡㻘㻠㻢㻞
◊䚷䚷䚷✲䚷䚷䚷䝇䚷䚷䚷䝍䚷䚷䚷䝑䚷䚷䚷䝣䚷䚷䚷㛵䚷䚷䚷ಀ䚷䚷䚷ᨭ䚷䚷䚷ฟ
㻢㻜㻜
㻢㻜㻜 Ꮫෆ㻞ே
㻜
㻜
㻜
㻜
㻢㻜㻜
Ꮫෆ㻞ே
䜲䞁䝣䝹䜶䞁䝄䜴䜱䝹䝇䜈䛾ឤᰁ㜼ᐖ䛾ྍ⬟ᛶ䛸⤖ྜ䛻క䛖䝅䜾䝘䝹ఏ㐩䛾ゎᯒ
−40−
᪂ᆺࣥࣇ࢚ࣝࣥࢨேᶒ
ᕝᮏဴ㑻
ྠᚿ♫ᏛἲᏛ㒊ἲᚊᏛ⛉
♫⛉Ꮫⓗ࡞ഃ㠃ࡽࡣࠊࡇࢀࡲ࡛⤖᰾ឤᰁࡋࡓேࡀ⿕ࡿྍ⬟ᛶࡢ࠶ࡿேᶒ
ᢚไࡢᐇែᢕᥱཬࡧࡑࡢᑐ⟇࡞ྛ✀ឤᰁᝈ⪅ࡢேᶒಖㆤࢆࠊἲᚊᐙࡢ❧ሙ
ࡽ⾜ᨻ༠ຊࡋ࡞ࡀࡽ㐍ࡵ࡚ࡁࡓࠋ
ᅇࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀฟ⌧ࡍࡿ๓ࡽࠊ
ᩘ㔞ࡀ㊊ࡍࡿࡇࡀᠱᛕࡉࢀ࡚ࡁࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࣡ࢡࢳࣥࡢ᥋✀㡰
ࡘ࠸࡚ࠊேᶒ㓄៖ࡋ࡞ࡀࡽ⪃࠼ࡿᚲせᛶࢆ⾲᫂ࡋࠊ♫ⓗ࡞άືࡀไ⣙ࡉࢀ࡞
࠸᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ࡢἲᩚഛࠊᏛᰯ➼ࡢᩍ⫱ᶵ㛵ࡀ᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ
⟇ࢆㅮࡎࡿࡓࡵࡢἲᩚഛྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ
༢࡞ࡿἲᚊᏛⓗ࡞❧ሙࡽ࡛࡞ࡃࠊ⮬↛⛉Ꮫⓗ࡞᳨ウࡢ⤖ᯝᚓࡽࢀࡓࡼࡾᖜࡢ
ᗈ࠸▱ぢࢆᇶ♏⨨࠸ࡓྲྀࡾ⤌ࡳࡢྍ⬟࡛࠶ࡿࡇࡀࠊᮏ◊✲ࣉࣟࢪ࢙ࢡࢺࡢ㐍
ᒎࡍࡿㄢ⛬࡛ド᫂ࡉࢀࡓࠋ
ឤᰁᑐ⟇ಀࡿᅜᐙཬࡧᆅ᪉⾜ᨻࡢឤᰁᑐ⟇㛵ࢃࡿ㔜せ࡞ጤဨጤဨ
ࡋ࡚ᢤ᧻ࡉࢀࠊἲᚊᐙࡢ❧ሙࡽࠊ⮬↛⛉Ꮫ㠃ࡼࡾ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ
᪂ᆺࣥࣇ࢚ࣝࣥࢨྲྀࡾ⤌ࢇ࡛࠸ࡿᮏ◊✲ࣉࣟࢪ࢙ࢡࢺ⮬↛⛉Ꮫศ㔝ࡢㅖ◊✲
⌜ဨࡢᐦ᥋࡞ሗࡼࡿ༠ྠయไࢆࡾࠊࡼࡾ᭷ຠ࡞᪂ᆺࣥࣇ࢚ࣝࣥࢨ
ᵝࠎ࡞ឤᰁࡢ㜵ᑐ⟇ࡢᅜᐙⓗ࡞ࣞ࣋ࣝ࠾ࡅࡿᵓ⠏ᑾຊࡋ࡚࠸ࡿࠋ
ᐇ㝿ࠊྠᚿ♫ᏛᏛ㝔㌿⡠ࡋࡓ┤ᚋࡢ 2012 ᖺ 4 ᭶ 12 ᪥㛤ദࡉࢀࡓ➨
180 ᅇᅜཧ㆟㝔ෆ㛶ጤဨཧ⪃ேࡋ࡚ᣍ⪸ࡉࢀࠊ
ࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ
⟇≉ูᥐ⨨ἲࠖᡂ❧㔜せ࡞ᙺࢆᯝࡓࡍࡇࡀ࡛ࡁࡓࠋࡑࡢᚋࠊ2012 ᖺ 8 ᭶
7 ᪥ࠊ
ᨻᗓࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇᭷㆑⪅㆟ᵓᡂဨᑵ௵ࡋࡓ
㸦௵ᮇࡣ 2014
ᖺ 8 ᭶ 6 ᪥ࡲ࡛㸧
ࠋ
−41−
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ➼ࡢࢹ࣮ࣗࣝࣘࢫ㜵Ṇࡼࡿ♫ࡢᏳ࣭Ᏻᚰ
㈉⊩ࡍࡿேᮦ⫱ᡂࡢᚲせᛶ
ᒾᮏㄔ࿃
ி㒔⏘ᴗᏛἲᏛ㒊ἲᨻ⟇Ꮫ⛉
ᖹᡂ 22 ᖺ 11 ᭶ 9 ᪥(ⅆ)㫽ྲྀᏛ㎰Ꮫ㒊࠾࠸࡚ࠊ㫽ྲྀᏛ㎰Ꮫ㒊⋇་Ꮫ⛉
Ꮫ⏕ᑐࡋ࡚ࠊ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ➼ࡼࡿ⏕≀රჾ࠶ࡿ࠸ࡣ⏕≀ࢸࣟࡢ
ᐇែཬࡧࡑࡢ㜵Ṇ⟇ࡘ࠸࡚ࠊ≉ูㅮ₇ࢆᐇࡋࡓࠋᒱ㜧Ꮫᛂ⏝⏕≀⛉Ꮫ㒊⋇
་Ꮫㄢ⛬Ꮫ⏕ࡶࠊࢸࣞࣅࡼࡿ㐲㝸ㅮ⩏࠸࠺ᙧᘧ࡛ཷㅮࡋࡓࠋ
ㅮ⩏ࡣࠊᅜ㝿ἲࡢᑓ㛛ᐙ࡛࠶ࡿ࠸࠺❧ሙࡽࠊ⏕≀ࢸࣟⓎ⏕ࡢ༴㝤ᛶࡑࡢ
⫼ᬒࠊ⏕≀ࢸࣟࢆᕠࡿᅜෆእࡢ≧ἣ࠾ࡼࡧ༴ᶵ⟶⌮࠾ࡅࡿ⋇་ᖌࡢᯝࡓࡍᙺ
ࡘ࠸࡚ᐇࢆ࠶ࡆ࡚ㅮ㏙ࡋࡓࠋ
ࠕ⏕≀ࢸࣟᴫㄽ≉ูㅮ⩏ࡢᵝᏊࠖ
−42−
−43−
−44−
−45−
−46−
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᾐ₶≧ἣࡢᢕᥱ࢘ࣝࢫࡢኚ␗㛵ࡍࡿ◊✲
㧘᱓ ᘯᶞ 㻝㻘㻟㻕ࠊ⸭⏣ῄண 㻝㻕ࠊୖ⍞Ụ 㻝㻕ࠊᖖᅧⰋኴ 㻝㻕ࠊᵳබ୍ 㻝㻘㻞㻘㻟㻘㻠㻕㻌
ி㒔⏘ᴗᏛ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮㻝㻕㻌
㻌 㻌 㻌 㻌 㻌 㻌 ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤ 㻞㻕㻌
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊ື≀⏕་⛉Ꮫ⛉ 㻟㻕㻌
㫽ྲྀᏛ㎰Ꮫ㒊㝃ᒓ㫽⏤᮶ே⋇ඹ㏻ឤᰁᏛ◊✲ࢭࣥࢱ࣮㻠㻕㻌
㻌
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㛵ࡍࡿ◊✲ࢆ㛗ᖺ⥆ࡅ࡚ࡁࡓᮏ◊✲ࣉࣟࢪ࢙ࢡࢺ
࣓ࣥࣂ࣮ࡣࠊḟࡢ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫฟ⌧㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
ࡣ῝ࡃ㛵ࡍࡿྍ⬟ᛶࢆ⪃࠼ࠊ
ࡋࡶ᭱ึฟ⌧ࡍࡿࡢࡣ +1 㫽ࣥࣇ࢚ࣝࣥࢨ
࢘ࣝࢫࡀ⃰ᐦศᕸࡍࡿࢪᆅᇦࠊ≉୰ᅜࡶࡋࡃࡣᮾ༡ࢪࡢྍ⬟ᛶࡀ
᭱ࡶ㧗࠸ࡢ࡛ࡣ࡞࠸ணࡋ࡚࠸ࡓࠋࡑࡇ࡛ࠊ࣋ࢺࢼ࣒㒊ࢆ୰ᚰࠊ⏕ᜥࡍ
ࡿྛ✀㔝㫽ࠊ㭜ࡸࣄࣝ➼ࡢᐙࡁࢇ㢮ࢱ࣮ࢤࢵࢺࢆ⤠ࡾㄪᰝࢆ⾜ࡗࡓࠋࡑࡢ⤖
ᯝࠊ+1 ࢘ࣝࢫࡣୖグ㫽㢮ࡽ⛥ศ㞳ࡉࢀࡓࡢࡳ࡛࠶ࡗࡓࡀࠊேࡢឤᰁຊ
ࡶᙅࡃ࡞࠸ูࡢளᆺࠊࡍ࡞ࢃࡕࠊ+1ࠊ+1 ࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆࠊ㭜
ࡸࣄࣝࡽࡤࡾ࡛࡞ࡃࠊᵝࠎ࡞㔝㫽ࡽ࡞ࡾ㢖⦾ศ㞳࡛ࡁࡓࠋ
ࡍ࡞ࢃࡕࠊ࣋ࢺࢼ࣒ࡢࡼ࠺࡞ᮾ༡ࢪㅖᅜ࡛ࡣࠊ᪥ᮏᅜෆࡢ≧ἣࡣࡃ␗
࡞ࡾࠊ㣫⫱ࡉࢀ࡚࠸ࡿ㭜⩌ࡸࣄࣝ࠾࠸࡚ࠊእぢୖᗣ࡛࠶ࡗ࡚ࡶࠊ+1 ளᆺ
࢘ࣝࢫࡢከ✀㢮ࡢளᆺࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆᖖಖ᭷ࡋ࡚࠸ࡿࡇ
ࢆึࡵ࡚᫂ࡽࡋࡓࠋ≉➹ࡍࡁࡣࠊእぢୖᗣ࡞ࣄࣝ➼ࡢỈࡁࢇ㢮ࡶࠊᙉ
ẘࡢ +1 㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁࡋ࡚࠸ࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋ
ࡇࢀ
ࡽࡢᅜࠎ࡛ࡣࠊ
ேࡶ +1 ளᆺࡢࡳ࡞ࡽࡎᵝࠎ࡞ளᆺࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
㢧ᛶឤᰁࡋ࡚࠸ࡿྍ⬟ᛶࡶྰᐃ࡛ࡁ࡞࠸ࡇࡀศࡗ࡚ࡁࡓࠋ ࡋࡓࡀࡗ࡚ࠊ㏆࠸ᑗ᮶ࠊᮾ༡ࢪࡽ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⏤᮶ࡍࡿ
᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢฟ⌧ࡍࡿࡇࡣ༑ศ⪃៖ࡍࡿᚲせࡢ࠶ࡿࡇࡀ᫂ࡽ
࡞ࡗࡓࠋࡓࡔࡋࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢளᆺࡣ +1 㝈ᐃࡋ࡞࠸ྍ⬟ᛶ
ࡣᑡ࡞ࡃ࡞࠸ࠋ
ࡇࢀࡽࡢᮾ༡ࢪ࠾ࡅࡿ◊✲ᡂᯝཬࡧᐇ㝿 ᖺ⡿㝣ࡽୡ⏺
ᣑᩓࡋࡓ +1 ளᆺࡢࣈࢱ⏤᮶ࡢ࢘ࣝࢫࡼࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ㛵ࡍࡿ
Ꮫⓗሗཬࡧཎᅉ࢘ࣝࢫࡢᴫ␎ࢆࠊᩘ⌮ⓗ࡞ゎᯒࢆᐇࡋ࡚࠸ࡿᮏࣉࣟࢪ࢙
ࢡࢺ⌜ဨ♫⛉Ꮫࢆᑓ㛛ࡍࡿ◊✲⌜ဨྍ⬟࡞㝈ࡾᥦ౪ࡋࡓࠋ
ᴗࡢඹྠసᴗ࡛ࠊᢠ࢘ࣝࢫస⏝ࡢ࠶ࡿ⣲ᮦࡢ㛤Ⓨࡶᘬࡁ⥆ࡁດຊࡋ࡚
࠾ࡾࠊ୍ᐃࡢᡂᯝࢆฟࡍࡇࡀ࡛ࡁࡓࠋ◊✲௦⾲⪅ࡢᵳࡣࠊ♫⛉Ꮫⓗ࡞ഃ㠃
ࡽࠊᮏ◊✲ࣉࣟࢪ࢙ࢡࢺⓎ㊊௨᮶ᵝࠎ࡞ሙᡤ࡛ࠊ᪂ᆺࣥࣇ࢚ࣝࣥࢨࢆど㔝
ධࢀࡓࠊ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㛵ࡋ࡚ࡇࢀࡲ࡛
ᚓࡽࢀࡓ◊✲ᡂᯝࠊ࠶ࡿ࠸ࡣ㫽ࣥࣇ࢚ࣝࣥࢨ࠶ࡿ࠸ࡣ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢⓎ
⏕ཬࡧୡ⏺ⓗ࡞ᗈࡀࡾ㛵ࡍࡿ᭱᪂ࡢሗࢆࠊ୍⯡ᕷẸࢆྵࡴྛ᪉㠃ᖜᗈࡃᥦ
౪ࡋ࡚ࡁࡓࠋ ᖺ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀฟ⌧ࡋࡓ㝿ࡣࠊ᪂ᆺࣥࣇ࢚ࣝࣥ
ࢨࡢ≉ᚩࠊࡑࡢ㏻ᖖࡢ᪥ᖖ⏕άཬࡰࡍᙳ㡪ࠊཬࡧࡑࡢᑐᛂ⟇☜❧ࡘ࠸࡚ࠊᖜ
ᗈ࠸ၨⵚάືບࢇ࡛࠸ࡿࠋ
−47−
ࡲࡓࠊᮏࣉࣟࢪ࢙ࢡࢺ◊✲⌜ᡤᒓࡍࡿ㸦ࡋࡓ㸧◊✲⪅ࡣࠊ㏆␥ᆅ༊ࡢ㸰ᗓ㸲
┴㸦㜰ᗓࠊி㒔ᗓࠊ㈡┴ࠊዉⰋ┴ࠊḷᒣ┴ࠊරᗜ┴㸧ࡢᐙ␆㜵ဨࠊ㫽
ࣥࣇ࢚ࣝࣥࢨデ᩿ᢏ⾡ࡢㅮ⩦ࢆᐇࡋ࡚࠾ࡾࠊබⓗᶵ㛵ᑐࡍࡿ♫㈉⊩ࡶ
ᑾຊࡋ࡚࠸ࡿࠋ㻌
−48−
᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢఏ㏿ᗘࡢᩘ⌮ࣔࢹࣝ
⣽㔝㞝୕
ி㒔⏘ᴗᏛ⌮Ꮫ㒊ᩘ⌮⛉Ꮫ⛉
᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢᛶ≧ࢆᢕᥱࡋ࡞ࡀࡽࠊឤᰁࡢఏ㛵ࡍࡿᇶ
ᮏⓗ࡞ᩘ⌮ࣔࢹࣝ㛵ࡍࡿ◊✲ࡢࢧ࣮࣋ࢆᐇࡋࡓࠋ✵㛫ⓗ࡞ఏࢆ⪃ᐹࡍࡿ
ࡓࡵࡢࣔࢹࣝࡋ࡚ࠊᣑᩓᛂࣔࢹࣝࠊ✚ศ᪉⛬ᘧࣔࢹࣝࠊࢿࢵࢺ࣮࣡ࢡࣔࢹࣝ
➼ࡢ≉ᚩࢆ⪃ᐹࡋ࡚࠸ࡿࠋ㠀ᖖ⡆༢࡛ᇶ♏ⓗ࡞ࣔࢹࣝࡢᩘ⌮ゎᯒࡽึࡵ࡚࠸
ࡿࡀࠊ2009 ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡀணࡋࠊ᪩ᮇᚑ᮶ࡢᏘ⠇ᛶ
ࣥࣇ࢚ࣝࣥࢨኚࢃࡗ࡚ࡋࡲࡗࡓࡓࡵࠊ◊✲ࡣึᮇẁ㝵ࡲࡗ࡚࠾ࡾࠊ
ࡁ࡞㐍ᒎࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ
⌧ᐇࠊឤᰁᩘ⌮ࣔࢹࣝࡢࡶࡘᛶ㉁ࢆゎ᫂ࡍࡿࡓࡵࡣࠊᩘ⌮ゎᯒࡢࡳ࡞ࡽ
ࡎᩘ್ࢩ࣑࣮ࣗࣞࢩࣙࣥࡀྍḞ࡛࠶ࡾࠊࡑࡢࣉࣟࢢ࣒ࣛ㛤Ⓨࡀィ⏬㏻ࡾ㐍ࡲ࡞
ࡗࡓࡓࡵࠊ
ᚋࠊ
ࡢ◊✲⪅ࡢ༠ຊࡶᚓ࡚ྲྀࡾ⤌ࡴᚲせᛶࡀࡼࡾ㔜せ࡞ࡗࡓࠋ
ឤᰁᩘ⌮ࣔࢹࣝࠊࡾࢃࡅᛂᣑᩓࣔࢹࣝᇶ࡙ࡃឤᰁࡢఏ㐣⛬ࡢᩘ⌮
ⓗㅖᛶ㉁ࡢゎ᫂㸦⣽㔝㸧
ࠋ2009 ᖺฟ⌧ࡋࡓ᪂ᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㸦H1N1
2009 ᰴ㸧ࡣணࡋேᑐࡍࡿཎᛶࡀ⯡ⓗᙅࡗࡓࡓࡵࠊ㢧ᛶឤᰁࡶ
ὶࢆ༨ࡵࠊ᫂░࡞ゎᯒࡣᅔ㞴࡛࠶ࡗࡓࠋᚋࡉࡽࠊ᪂ࡋ࠸᪂ᆺࣥࣇ࢚ࣝࣥ
ࢨ࢘ࣝࢫࡢฟ⌧ࡍࡿྍ⬟ᛶࡣ㧗࠸ࡢ࡛ࠊ༑ศ࡞ഛ࠼ࢆࡋࡓ࠸ࠋ
−49−
ࣥࣇ࢚ࣝࣥࢨ $ ࢘ࣝࢫ 51$ ࣏࣓࣮ࣜࣛࢮࡢ ; ⥺⤖ᬗᵓ㐀ゎᯒ
ὠୗⱥ᫂ࠊ㭯ᮧಇࠊ⛅ ᾈ
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊⏕㈨※⎔ቃᏛ⛉
◊✲ィ⏬ࡢᴫせ
ࣥࣇ࢚ࣝࣥࢨA࢘ࣝࢫࡣࠊ࣐ࢼࢫ୍ᮏ㙐RNA8✀㢮ࡢࢱࣥࣃࢡ㉁ࡽᵓ
ᡂࡉࢀ࡚࠸ࡿࠋࡇࢀࡽࡢRNAࡸࢱࣥࣃࢡ㉁ࡢᐟ⣽⬊ෆ࡛ࡢቑṪࡣࠊPAࠊPB1ࠊ
PB2ࠊNPࡽ࡞ࡿRNA࣏࣓࣮ࣜࣛࢮ」ྜయࡀᢸࡗ࡚࠸ࡿࠋྛࢧࣈࣘࢽࢵࢺࡢᵝࠎ
࡞ࢻ࣓ࣥࡢᵓ㐀ゎᯒࡀⰍࠎ࡞ࢢ࣮ࣝࣉ࡛⾜ࢃࢀ࡚࠸ࡿࠋᡃࠎࡣࠊPB2ࡢCᮎ➃
ഃࡢࢻ࣓ࣥ㸦3/3㡿ᇦ㸦535-759㸧
㸧ࡢᵓ㐀ࢆ᫂ࡽࡋ࡚࠾ࡾࠊࡇࡢ㡿ᇦࡣ
ཎᛶࡢᙉᙅ✀㛫ࡢఏᰁᛶࢆỴᐃࡍࡿK627ࢆྵࢇ࡛࠸ࡿ㸦JBC㸦㸰㸮㸮㸷㸧
284,6855-6860࠾ࡼࡧ⥲ㄝ ⏕Ꮫ㸦ῧ㸧
㸧
ࠋࡇࡢRNA࣏࣓࣮ࣜࣛࢮࡢ」ྜయ࠶
ࡿ࠸ࡣࣄࢺࡢᅉᏊࡢ⤖ྜࢆ᫂ࡽࡍࡿ࡛ࠊᑗ᮶ⓗࡣࢱ࣑ࣇࣝࠊࣜࣞࣥࢨ
ࡣ␗࡞ࡿ᪂ࡓ࡞RNA࣏࣓࣮ࣜࣛࢮࡢ㜼ᐖࢆ⸆ࡍࡿࢆ┠ⓗࡋࡓࠋ
◊✲⤖ᯝࡢᴫせ
ᡃࠎࡣPB2ࡢ୰㛫ࢻ࣓ࣥ㡿ᇦ㸦318-483㸧ࢆPCRࡼࡗ࡚ቑࡸࡋࠊpET15bⓎ⌧
࣋ࢡࢱ࣮ᑟධࡋࠊBL21-RILࢥࢵࢺࣥࣉࣛࢫࢥࣥࣆࢸࣥࢺࢭ࡛ࣝⓎ⌧ࡋࡓࠋNi
࣒࡛࢝ࣛ⢭〇ࡋࠊ50mM Tris-HCl(PH8.0)ࠊ500mM NaCl 2mM DTTࡢࣂࢵࣇ
࣮᮲௳࡛ࠊ16mg/mlࡢ⃰ᗘࡲ࡛ࢱࣥࣃࢡ㉁ࢆ⃰⦰ࡋࡓࠋNaClࢆỿẊࡋ࡚⤖ᬗ
ࡀᚓࡽࢀࡓࠋ㠀⤖ᬗᏛⓗᑐ⛠༢ศᏊධࡗ࡚࠸ࡿ⤖ᬗ࡛ࠊศゎ⬟3.3Ȭࡢࢹ࣮
ࢱࢆᚓࡓࠋ✵㛫⩌ࡣP㸰㸯㸰㸯㸰㸯㸦a=75.7Ȭ,b=102.6Ȭ,c=110.2Ȭ㸧࡛࠶ࡾࠊR
factor=22.0% (R free=29.8%)ࡢᵓ㐀ࢆゎ᫂ࡋࡓࠋࡉࡽࠊPB2㛗ࡢᵓ㐀ゎᯒࢆ
┠ᣦࡋ࡚ࠊ㛗ࡢⓎ⌧ࡶ⾜ࡗ࡚࠸ࡿࠋ
ඃࢀࡓᡂᯝࡀ࠶ࡀࡗࡓⅬ
PB㸰࣑ࢻࣝࢻ࣓ࣥࡣࣄࢺࡢ mRNA ࡢ Cap ᵓ㐀ࢆㄆ㆑ࡍࡿࢻ࣓࡛ࣥ࠶ࡾࠊ
m(7)GTP ࡢඹ⤖ᬗᵓ㐀ࡣࣇࣛࣥࢫࢢ࣮ࣝࣉࡼࡾゎ᫂ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣ
H1N1 ᆺ࡛ጞࡵ࡚ࡢࠊPB㸰࣑ࢻࣝࢻ࣓ࣥࡢ⤖ᬗࢆᚓࡓࠋࡇࡢ⤖ᬗࢆ⏝࠸࡚㧗ศ
ゎ⬟ࡢࢹ࣮ࢱ࡛ᵓ㐀ࢆ᫂ࡽࡋࡓࠋᚨᓥᩥ⌮Ꮫⴱཎࡽඹྠ◊✲ࡼࡾࠊࡇ
ࡢࢻ࣓ࣥࡢ᪂つࡢάᛶࡘ࠸࡚ࡶ⌧ᅾ◊✲ࡀ㐍⾜ࡋ࡚࠸ࡿࠋᵓ㐀ࡘ࠸࡚ࡣࠊ
⌧ᅾࠊㄽᩥᢞ✏୰࡛࠶ࡿࠋ
ၥ㢟Ⅼ
⌧ᅾ PB2 ࡢ㛗ࡢⓎ⌧ྲྀࡾ⤌ࢇ࡛࠸ࡿࠋࡇࡢ⭠⳦࡛ࡢⓎ⌧ࡣ㞴ࡋ࠸ࡀࠊෆ㒊
ࢩࣕࣥࢲࣝ࢞ࣀ㓄ิ㢮ఝࡢࢩ࣮ࢣࣥࢫࢆᣢࡕࠊ
Ṉࢀࢆኚ␗ࡉࡏࡿࡇࡼࡾࠊ
ࡑࡢⓎ⌧ຠᯝࡀ࠶ࡿ᳨ウࡋ࡚࠸ࡿࠋ
◊✲ᮇ㛫⤊ᚋࡢᒎᮃ
ᙜヱ◊✲࡛ᇵࡗࡓࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ RNA ࣏࣓࣮ࣜࣛࢮࡢᵓ㐀◊✲ࡣࠊ
−50−
ࡲࡔୡ⏺୰ࡀὀ┠ࡋ࡚◊✲ࢆࡋ࡚࠸ࡿ㡿ᇦ࡛࠶ࡾࠊ
ࡑࡢ୕✀」ྜయࡢᵓ㐀ゎᯒࡣࠊ
᪂ࡓ࡞స⏝ᶵᵓࡢ㜼ᐖタィࡢࡓࡵࡶ㔜せ࡛࠶ࡿࠋ◊✲ᐊࡢ㔜せ࡞ࢸ࣮࣐ࡋ
࡚◊✲ࢆ⥅⥆ࡍࡿࠋ
−51−
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཷᐜయࡢゎᯒឤᰁᶵᵓࡢゎ᫂
୰⏣ ༤ࠊ⛅⏣ ⸅ࠊୖ⍞Ụࠊᮌ ⫕ࠊ▼⏣᭷ᕼᏊ
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊ࢩࢫࢸ࣒⏕⛉Ꮫ⛉
ࡣࡌࡵ
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢࡓࡿධ㒊ࡋ࡚ࡣࠊ⢓⭷ୖ⓶ࡀᣲࡆࡽࢀࡿࠋ
ྠ㒊ࡢ⣽⬊⾲㠃ࡣ࣒ࢳࣥࡤࢀࡿ⢾ࢱࣥࣃࢡ㉁そࢃࢀ࡚࠸ࡿࠋ୰࡛ࡶ⭷⤖
ྜᆺ࣒ࢳࣥࡢ 1 ࡘ࡛࠶ࡿ MUC1 ࡣ᭱ࡶᬑ㐢ⓗᏑᅾࡍࡿ࣒ࢳ࡛ࣥ࠶ࡿࠋ୍⯡ⓗ
࣒ࢳࣥࡣࢩࣟࢢࣜ࢝ࣥᐩࡳࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཷᐜయ࡞ࡿྍ⬟ᛶ
ࡀ㧗࠸ணࡉࢀࡓࠋ⣽⬊ࡋ࡚ࡣࠊ⫵ୖ⓶⏤᮶⣽⬊ᰴ࡛࠶ࡿ A549 ⣽⬊ࢆ⏝࠸
ࡓࠋྠ⣽⬊ࡣ MUC1 ࢆపⓎ⌧ࡋ࡚࠸ࡿࡇࢆ FACS ࡛☜ㄆࡋࡓࠋࡉࡽ
MUC1cDNA ࢆᑟධࡋࠊMUC1 㧗Ⓨ⌧ᰴ㸦A549H㸧ࢆᚓࡓࠋࣄࢺࣥࣇ࢚ࣝࣥࢨ
࢘ࣝࢫࡋ࡚ࡣࠊPanama ཬࡧ PR8 ᰴࢆ⏝࠸ࡓࠋ
1㸬ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⏘⏕㔞ࡢẚ㍑
A549 ཬࡧ A549H ⣽⬊ Panama ࠶ࡿ࠸ࡣ PR8 ᰴ(1000HA)ࢆ 1 㛫ឤᰁᚋࠊᇵ㣴
ᾮࢆࡋࠊ3 ᪥㛫ࣥࣥ࢟ࣗ࣋-ࢺࡋࡓࠋᇵ㣴ୖΎࡢ࢘ࣝࢫ㔞ࡣࠊA549,A549H
⣽⬊࠾࠸࡚ࠊPanamaࠊPR8 ᰴࡑࢀࡒࢀࠊA549H ⣽⬊ࡢ᪉ࡀࠊ⣙ 4 ཬࡧ 3 ಸࡢ
TCID50 ್ࢆ♧ࡋࡓࠋࡲࡓࠊྠᵝࠊ1 㛫ឤᰁᚋࠊᇵ㣴ୖΎ୰ᨺฟࡉࢀࡿ࢘
ࣝࢫࡣࠊ
⣙6㛫ᚋࡼࡾ᳨ฟࡉࢀࠊ
ࡑࡢᚋA549H⣽⬊࠾࠸࡚ⴭࡋࡃୖ᪼ࡋࡓࡀࠊ
A549 ⣽⬊࡛ࡣቑ࡛࠶ࡗࡓࠋ
ࡇࢀࡽࡢ⤖ᯝࡣࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁ
MUC1 ࡀ㛵ࡋ࡚࠸ࡿࡇࢆᙉࡃ♧၀ࡋࡓࠋࡲࡓࠊ⣽⬊ෆ࠾ࡅࡿ NP ࢱࣥࣃ
ࢡ㉁㔞ࡣ୧⣽⬊࠾࠸࡚ࡁ࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋ
㸰㸬ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫཷᐜయࡢ᳨⣴
࢘ࣝࢫࡢཷᐜయࢆ᳨⣴ࡍࡿ┠ⓗ࡛ࠊA549H ⣽⬊ࡢࣛࢭ-ࢺࢆㄪ〇ࡋࠊ
SDS-PAGE ᚋࠊZeta ࣉࣟ-ࣈ⭷࢚࢘ࢫࢱࣥࣈࣟࢵࢸࣥࢢࢆ⾜ࡗࡓࠋPanama ཬ
ࡧ PR8 ᰴࡢ࢘ࣝࢫ⾲㠃ࢱࣥࣃࢡ㉁ࢆࣅ࢜ࢳ࡛ࣥᶆ㆑ࡋࠊZeta ࣉࣟ-ࣈ⭷ࣥ
࢟ࣗ࣋-ࢺࡋࡓࠋὙίᚋࠊࢫࢺࣞࣉࢺࣅࢪࣥ-HRP ࢆ⏝࠸࡚ⓎⰍࡋࡓࠋ࠸ࡎࢀࡢ
࢘ࣝࢫࡶ 250kDa ௨ୖࡢࢫ࣑ࣖ-≧ࡢ㧗ศᏊ⢾ࢱࣥࣃࢡ㉁⤖ྜࡋࡓࠋᢠ MUC1
ᢠయࡼࡿ᳨ฟࡼࡾࠊྠࣂࣥࢻࡀ MUC1 ࡛࠶ࡿࡇࢆ☜ㄆࡋࡓࠋࡲࡓࠊ⭷ୖࡢ
࣒ࢳࣥࢆࢩࣜࢲ—ࢮฎ⌮ࡍࡿࡇࡼࡾࠊࡑࡢ⤖ྜࡀᾘኻࡍࡿࡇࡽࠊ࢘
ࣝࢫࡣ MUC1 ୖࡢࢩࣝ㓟≉␗ⓗ⤖ྜࡋ࡚࠸ࡿࡇࡀࢃࡗࡓࠋ
㸱㸬ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫឤᰁక࠺ MUC1 ࡢኚ
୍⯡ⓗࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣࠊࢩࣟࢢࣜ࢝ࣥ⤖ྜᚋࠊ⣽⬊ෆྲྀࡾ㎸
ࡲࢀࠊᨺฟࢩࣝ㓟ࢆษ㝖ࡋ࡚㐟㞳ࡍࡿࡉࢀ࡚࠸ࡿࠋឤᰁᚋࠊ⤒ⓗ⣽
⬊ࡢࣛࢭ-ࢺࢆㄪ〇ࡋࠊ㟁ẼὋືࡼࡾ MUC1 ࡢศᏊࢧࢬࡢኚࢆぢࡓࠋ࡞
࠾ࠊMUC1 ࡢࢩࣝ㓟ࡀษ㝖ࡉࢀࡿ㟁ẼὋືୖ࡛ࡣ㝜ᛶⲴ㟁ࡢῶᑡࡼࡾࠊ⛣
ື⬟ࡀపୗࡋࠊぢࡅୖ㧗ศᏊࡍࡿࡇࡀࢃࡗ࡚࠸ࡿࠋឤᰁᚋ 5 㛫⛬ᗘࡲ
−52−
࡛ࡣࠊMUC1 ኚࡣぢࡽࢀ࡞ࡗࡓࡀࠊ10 㛫ࢆ㉸࠼ࡿ㧗ศᏊࡋࠊࢩࣝ
㓟ࡀษ㝖ࡉࢀࡿࡇࡀࢃࡗࡓࠋྠ PNA ࣞࢡࢳࣥࡢ⤖ྜࡀቑࡋࠊࢩࣝ㓟
ࡀษ㝖ࡉࢀ࢞ࣛࢡࢺ-ࢫࡢ㟢ฟࡀࡅࡽࢀࡓࠋMUC1 ࢆ in vitro ࡛⬺ࢩ
ࣝࡋࡓヨᩱࡶὋືᗘࡀ୍⮴ࡍࡿࡇࡽࠊ࢘ࣝࢫࡢ NA ࡼࡾࡰࡍ
࡚ࡢࢩࣝ㓟ࡀឤᰁ㝖ཤࡉࢀࡓࡇࢆ♧ࡋ࡚࠸ࡿࠋ࢚ࣥࢻࢰ-࣒ࡸࣜࢯࢰ-࣒
ࡢᡴࡕࢱࣥࣃࢡ㉁࡛࠶ࡿ LAMP-1ࠊ2 ࡘ࠸࡚ࡶࠊྠᵝឤᰁ⬺ࢩࣝ
ࡀ㉳ࡇࡿࡽࠊ࢘ࣝࢫࡢධక࠸ࠊ࢚ࣥࢻࢧࢺ-ࢩࢫ⣽⬊ෆࡢ㝈ࡽࢀ
ࡓࢥࣥࣃ-ࢺ࣓ࣥࢺ࡛ຠ⋡ⓗࢩࣝ㓟ࡀ㝖ཤࡉࢀ࡚࠸ࡿࡇࢆ♧၀ࡋ࡚࠸ࡿࠋ
㸲㸬ࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁక࠺ሗఏ㐩
ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᚋࡢ MUC1 ࢆࡋࡓሗఏ㐩ࡘ࠸࡚ࠊERK,p38,
ཬࡧ Akt ࡢࣜࣥ㓟ࡘ࠸᳨࡚ウࡋࡓࠋࡍ࡞ࢃࡕࠊ࢘ࣝࢫឤᰁᚋࡢ A549 ཬࡧ
A549H ⣽⬊ࡼࡾࠊ⤒ⓗ⣽⬊ࡢࣛࢭ-ࢺࢆㄪ〇ࡋࠊSDS-PAGEࠊ࢚࢘ࢫࢱࣥࣈ
ࣟࢵࢸࣥࢢᚋᢠࣜࣥ㓟 ERK ᢠయࠊᢠࣜࣥ㓟 p38 ᢠయࠊᢠࣜࣥ㓟 Akt
ᢠయࢆ⏝࠸᳨࡚ฟࡋࡓࠋឤᰁᚋࡢẚ㍑ⓗ▷㛫ෆࡢࢩࢢࢼࣝఏ㐩ࡘ࠸࡚ࡣࠊ୧
⣽⬊࠾࠸࡚᭷ពࡢ⤖ᯝࡣᚓࡽࢀ࡞ࡗࡓࠋᚑࡗ࡚ࠊMUC1 ࡣ࢘ࣝࢫࡢྲྀࡾ㎸
ࡳࡢࡳ㛵ࡋ࡚࠸ࡿࡶࡢணࡉࢀࡿࠋࡋࡋ࡞ࡀࡽࠊឤᰁᚋ 6 㛫⛬ᗘ⤒㐣
ࡋࡓ୧⣽⬊ࡘ࠸࡚ࠊERK ཬࡧ p38 ࡘ࠸࡚ᕪ␗ࡣㄆࡵࡽࢀ࡞ࡗࡓࡀࠊAkt
ࡘ࠸࡚┦㐪ࡀㄆࡵࡽࢀࡓࠋࡍ࡞ࢃࡕࠊAkt ࡢࣜࣥ㓟ࡀࠊA549 ⣽⬊ࡢ᪉ࡀ A549H
⣽⬊ࡼࡾஹ㐍ࡋࠊࡑࡢഴྥࡣ 12 㛫⛬ᗘࡲ࡛ぢࡽࢀࡓࠋAkt ࡢάᛶࡣ࣏ࢺࢩࢫࢆᢚไࡍࡿࡇࡀ▱ࡽࢀ࡚࠸ࡿࡇࡽࠊࣛࢭ-ࢺࡢ㟁ẼὋືཬࡧ࢚࢘ࢫࢱ
ࣥࣈࣟࢵࢸࣥࢢᚋ࢝ࢫࣃ-ࢮ㸱ࡢάᛶࢆẚ㍑ࡋࡓࡇࢁࠊA549H ⣽⬊ࡢ᪉
ࡀ㧗ࡃࠊ࣏ࢺ-ࢩࢫࡀ A549H ⣽⬊࡛ಁ㐍ࡋ࡚࠸ࡿࡇࡀࢃࡗࡓࠋࡲࡓࠊTUNEL
ἲࡼࡿ⣽⬊ᰁⰍࡼࡗ࡚ࡶ A549H ⣽⬊࡛࣏ࢺ-ࢩࢫࡀஹ㐍ࡋ࡚࠸ࡿࡇࡀࢃ
ࡗࡓࠋᚑࡗ࡚ࠊMUC1 㧗Ⓨ⌧⣽⬊ᰴ࡛ࡣࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁᚋࠊ
Akt ࡢάᛶࡀ MUC1 పⓎ⌧ᰴࡼࡾᢚไࡉࢀࡿ⤖ᯝࠊ࣏ࢺ-ࢩࢫࡀ㉳ࡇࡾࠊࡼࡾ
ከࡃࡢ࢘ࣝࢫ⢏Ꮚࡀᇵ㣴ୖΎᨺฟࡉࢀࡓࡶࡢ⪃࠼ࡽࢀࡿࠋ
㸳㸬ㄢ㢟ᑗ᮶ᒎᮃ
⭷⤖ྜᆺ࣒ࢳ࡛ࣥ࠶ࡿ MUC1 ࡀࣄࢺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢཷᐜయࡋ࡚
ᶵ⬟ࡍࡿࡇࢆึࡵ࡚᫂☜♧ࡋࡓࠋMUC1 㧗Ⓨ⌧ᰴ࡛ࡼࡾຠᯝⓗࣥࣇ࢚ࣝ
ࣥࢨ࢘ࣝࢫࡀ⏘⏕ࡉࢀࠊ⣽⬊እᨺฟࡉࢀࡿࡇࢆ♧ࡍࡶࡑࡢศᏊⓗ⫼
ᬒࡋ࡚ࠊ࣏ࢺ-ࢩࢫࡀㄏᑟࡉࢀࡿࡇࢆ♧ࡋࡓࠋ
ࡋࡋ࡞ࡀࡽࠊ࢘ࣝࢫឤᰁక࠸ MUC1 㧗Ⓨ⌧ᰴ࠾ࡅࡿ࣏ࢺ-ࢩࢫࡢㄏ
ᑟࡘ࠸࡚ࠊMUC1 ࡢᅉᯝ㛵ಀࢆࡉࡽ᫂☜ࡍࡿⅬࡀṧࡉࢀ࡚࠸ࡿࠋࣥࣇࣝ
࢚ࣥࢨ࢘ࣝࢫࡢ⏘⏕ࡍࡿࢱࣥࣃࢡ㉁࡛࠶ࡿ NS1 ࡀ MUC1 㧗Ⓨ⌧ᰴ࡛ῶᑡࡋࠊ
ࡘ Akt ࢆάᛶࡍࡿࢱࣥࣃࢡ㉁࡛࠶ࡿࡇࡽࠊ
NS1 MUC1ࠊ
ࡾࢃࡅ MUC1
ࡢ C ᮎࢻ࣓ࣥࡢ┦స⏝ศゎゎỴࡢ⣒ཱྀࡀ࠶ࡿ⪃࠼࡚࠸ࡿ
MUC1 ศᏊ㛵ࡋ࡚ࡣࠊ⒴⣽⬊ࡢ◊✲ࡽ⣽⬊ෆ࡛ࡢᶵ⬟ศᏊࡋ࡚ࡢ C ᮎࢻ
࣓ࣥࡘ࠸࡚ከࡃࡢ◊✲ᡂᯝࡀ࠶ࡾࠊ࢘ࣝࢫࢱࣥࣃࢡ㉁ࡢ┦స⏝࡞ࡀ
ᐃࡉࢀࡿࠋࡇࡢࡼ࠺࡞どⅬࡼࡾ MUC1 ཷᐜయ࢘ࣝࢫࡢ⏘⏕ஹ㐍ࡢ㛵ಀࢆࡼ
−53−
ࡾ᫂☜ࡍࡿࠋࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫཷᐜయ㛵㐃ࡍࡿሗఏ㐩ศᏊࢆᑐ㇟
ࡋ࡚ࠊ᪂ࡓ࡞࢘ࣝࢫឤᰁ㜼ᐖࡋ࡚ࠊsiRNA ࡞ࡢྍ⬟ᛶࢆ᳨ウࡍࡿࠋࡲࡓࠊ
⣽⬊⾲㠃ࡢ⢾㙐ࢆㄆ㆑ࡍࡿ࠸ࡃࡘࡢཎᛶ࢘ࣝࢫࡀ▱ࡽࢀ࡚࠾ࡾࠊᮏ◊✲ᡂ
ᯝࢆࡶࡼࡾᗈ⠊࡞◊✲ࢆᒎ㛤ࡋࡓ࠸ࠋ
−54−
⢾㙐࣐ࢡࣟࣞᢏ⾡ࢆ⏝࠸ࡓ⢾㙐⤖ྜᛶࡢ㐪࠸ᇶ࡙ࡃࠊࣥࣇ࢚ࣝࣥࢨ
࢘ࣝࢫࣆࣟࣜ⳦ࡢศ㢮ཎᛶࡢ㛵㐃ࡘ࠸࡚
㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 ⚟ᡂ⾜䚸ᕝཎ⍞✠
㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 㻌 ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊䝅䝇䝔䝮⏕⛉Ꮫ⛉
㻌 ⢾㙐䛿ཎ᰾⣽⬊䛸┿᰾⣽⬊䛻ᗈ䛟Ꮡᅾ䛩䜛ከᵝ䛺ሗ䜢ᣢ䛴ศᏊ䛷䚸⢾䝍䞁䝟䜽㉁䚸
⢾⬡㉁䚸䝥䝻䝔䜸䜾䝸䜹䞁䛸䛧䛶Ꮡᅾ䛩䜛䚹⢾㙐䛾ᢸ䛖⏕≀Ꮫⓗ䛺ᙺ䛸⣽⬊䛾䛜䜣
䛻క䛳䛶Ⓨ⌧䛥䜜䜛≉␗⢾㙐䛾ฟ⌧䛺䛹䛜᫂䜙䛛䛸䛥䜜䛶䛝䛯䛜䚸⣽⬊㛫᥋╔䚸䜴䜲䝹
䝇ཷᐜయ䛸䛾⤖ྜ䚸⣽⬊ቑṪ䝅䜾䝘䝹䜢䛘䜛⢾㙐䚸⢾㙐䛻స⏝䛩䜛䝍䞁䝟䜽㉁䚸䛭
䛾୧⪅䛻䜘䜛┦స⏝䛾⤖ᯝ䛸䛧䛶⏕䛨䜛⏕⌮άᛶ䛾ㄪ⠇䚸䛺䛹ከ䛟䛾Ⅼ䛜ᚋ䛾◊
✲┠ᶆ䛸䛧䛶᫂䛸䛧䛶ṧ䛥䜜䛶䛔䛯䚹䛭䛣䛷䚸⢾㙐-䝍䞁䝟䜽㉁㛫䛾┦స⏝䜢ᚤ㔞
䛺⢾㙐䜢䚸㧗ឤᗘ䛷䛧䛛䜒ᩄ㏿䛻ㄪ䜉䜛᪉ἲ䛜☜❧䛥䜜䜜䜀⢾㙐◊✲䛾୍ຓ䛸䛺䜛䛸
⪃䛘䚸䝙䝖䝻䝉䝹䝻䞊䝇⭷㠃ୖ䛻⮬↛⏺䛻Ꮡᅾ䛩䜛⢾䝍䞁䝟䜽㉁䚸⢾⬡㉁䚸䝥䝻䝔䜸䜾
䝸䜹䞁䛛䜙㐟㞳䛥䛫䛯ᚤ㔞䛺䠄p mol ⛬ᗘ䠅⢾㙐䜢ᅛ┦䛧䚸どぬⓗ䛺䝅䜾䝘䝹䛸䛧䛶⢾
㙐⤖ྜ䝍䞁䝟䜽㉁䛾⤖ྜ䜢ゎᯒ䛷䛝䜛⢾㙐䝬䜲䜽䝻䜰䝺䜲ἲ䜢☜❧䛧䛯䚹䛩䛺䜟䛱䚸⢾
㙐ㄆ㆑䝍䞁䝟䜽㉁䛸䛧䛶䚸⢾㙐䛸䛾ゎ㞳ᐃᩘ䛜 10-6-10-3 䠩⛬ᗘ䛷䛒䜛䛸ሗ࿌䛥䜜䛶䛔
䜛ື᳜≀⏤᮶䛾䝅䜰䝹㓟ㄆ㆑䝍䞁䝟䜽㉁䛻ὀ┠䛧䚸䝅䜰䝹㓟ྵ᭷⢾㙐䜢㆑ู䛩䜛᳜
≀ lectins 䛸䛧䛶䛿 SNA, MAA䚸ື≀⏤᮶䛾䜒䛾䛸䛧䛶 siglecs(siglec-2, siglec-3)䜢ྲྀ䜚ୖ
䛢䛯䚹
㻌 ⢾㙐䛸䛧䛶 lacto-N-tetraose, Lacto-N-neotetraose 䛾䠐⢾䜢ᇶᮏ䠄䝁䜰䠅⢾㙐䛸䛧䛶䚸䝅䜰
䝹㓟䛜䃐2.3, 䃐 2,6 ⤖ྜ䛧䛯䜚䚸䝣䝁䞊䝇䜒⤖ྜ䛧䛯ᵝ䚻䛺⢾㙐䜢㓝⣲ⓗ䛻ㄪ〇䛧䛯䚹
᭦䛻䚸䜺䞁䜾䝸䜸䝅䝗⣔䛾⢾㙐 GM1䚸endo-ceramidase 䛻䜘䜚㐟㞳䛥䛫䛯䝅䜰䝹㓟ྵ᭷
ኳ↛⢾㙐䜢ㄪ〇䛧䛯䚹䛭䛾⤖ᯝ䚸᳜≀䝺䜽䝏䞁䛾 SNA 䛿 NeuAc䃐2,6Gal-䛸 NeuAc䃐
2,6GalNAc-䛾ᵓ㐀䜢ᣢ䛴⢾㙐䛻⤖ྜ䝅䜾䝘䝹䜢䛘䚸䛭䛾⤖ᯝ䛿䛣䜜䜎䛷䛾ሗ࿌䛸
䜘䛟୍⮴䛧䛶䛔䛯䚹䛧䛛䛧䚸NeuAc䃐2,6Gal䃑1,4GlcNAc-䛻䜒᭦䛻ᙉ䛟⤖ྜ䛧䛯䛣䛸䛛䜙䚸
SNA 䛿䝅䜰䝹㓟䛜䃐2,6 ⤖ྜ䛷(neo)lactosamine 䛻⤖ྜ䛧䛯⢾㙐䛜 SNA 䛾┿䛾䝸䜺䞁
䝗⢾㙐䛸⪃䛘䜙䜜䛯䚹
㻌 ୍᪉䚸MAA 䛿 NeuAc䃐2,3Gal䃑1,3/4GlcNAc-䛾⢾㙐䛻⤖ྜ䛧 Gal 䛾⤖ྜ䛜䃐1,3
䛷䛒䛳䛶䜒䃐1,4 䛷䛒䛳䛶䜒ྠ⛬ᗘ䛷䛒䜛䛸ሗ࿌䛥䜜䛶䛔䛯䛜䚸NeuAc䃐2,3Gal䃑
1,4GlcNAc-䛻䛿⤖ྜ䛩䜛䛜䚸3Gal 䛜䃐1,3 ⤖ྜ䛷 GlcNAc 䛻⤖ྜ䛧䛯⢾㙐䛻䛿䛟⤖
ྜ䛧䛺䛟≉␗ᛶ䛜㧗䛔䛣䛸䜢ㄆ䜑䛶䛯䚹ྠᵝ䛻䚸䝠䝖⏤᮶䛾ື≀䝺䜽䝏䞁䛷䛒䜛 Siglec-3
䛿䚸NeuAc䃐2,3Gal䃑1,4GlcNAc-䛸 NeuAc䃐2,6Gal䃑1,4GlcNAc-䛻ྠ⛬ᗘ䛾ᙉ䛔⤖
ྜ䝅䜾䝘䝹䜢䛘䛯䛜䚸NeuAc䃐2,3Gal䃑1,3GlcNAc-䛻䛿ᙅ䛟䝅䜾䝘䝹䜢䛘䚸Gal
䃑1,4 ⤖ྜ䜢䜘䜚ᙉ䛟㆑ู䛩䜛䛣䛸䜢ㄆ䜑䛯䚹䛣䛾⤖ᯝ䛿䚸1 pmol 䛾⢾㙐䜢ᅛ┦䛧䛯
⢾㙐䝬䜲䜽䝻䜰䝺䜲䛜䚸䝅䜰䝹㓟䜢ㄆ㆑䛩䜛䝍䞁䝟䜽㉁䛾䝸䜺䞁䝗⢾㙐䜢ⓗ☜䛻
single-out 䛷䛝䜛䛾䜏䛺䜙䛪䚸䝅䜰䝹㓟䛾⤖ྜᵝᘧ䠄Gal 䛜䃐1,3 䃐1,4 䛷 GlcNAc or
GacNAc 䛻⤖ྜ䛧䛶䛔䜛䛛䠅䜢䜒㆑ู䛷䛝䜛䛣䛸䛜♧䛥䜜䛯䚹
㻌 A ᆺ㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇 HA 䝍䞁䝟䜽㉁䛜⤖ྜ䛩䜛⢾㙐䛿䚸䛣䜜䜎䛷䛾ከ䛟䛾
◊✲䛛䜙䚸㫽ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇 HA 䝍䞁䝟䜽㉁䛾⤖ྜ⢾㙐䛿䚸⢾㙐䛾㠀㑏ඖ
ᮎ➃䛻α2,3 ⤖ྜ䛧䛯䝅䜰䝹㓟䜢䜒䛴⢾㙐ᵓ㐀䜢᭷䛧䚸䝠䝖ᆺ䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇
−55−
HA 䝍䞁䝟䜽㉁䛾䛭䜜䛿α2,6 ⤖ྜ䛧䛯䝅䜰䝹㓟䜢䜒䛴⢾㙐ᵓ㐀䛸䛥䜜䛶䛔䛯䛜䚸䝅䜰䝹
㓟䛾⤖ྜ䛩䜛䜺䝷䜽䝖䞊䝇䜢ྵ䜐㑏ඖᮎ➃ഃ䛾⢾㙐䛾ᵓ㐀౫Ꮡᛶ䛻䛴䛔䛶䛿䛟
᫂䛷䛒䛳䛯䚹䛭䛣䛷䚸ᵝ䚻䛺䝅䜰䝹㓟ྵ᭷⢾㙐䜢 neoglycolipid 䛧䝙䝖䝻䝉䝹䝻䞊䝇⭷
䛻ᅛ┦䛩䜛䝬䜲䜽䝻䜰䝺䜲ἲ䜢⏝䛧䛶㫽ᆺ䛸䝠䝖ᆺ HA 䝍䞁䝟䜽㉁䛾ㄆ㆑䛩䜛ヲ⣽
䛺⢾㙐ᵓ㐀䜢᫂䜙䛛䛻䛧䜘䛖䛸ヨ䜏䛯䚹䛧䛛䛧䛺䛜䜙䚸ᅛ┦䛧䛯ᚤ㔞⢾㙐䛸䛾⤖ྜ䜢
ㄪ䜉䜛⢾㙐䝬䜲䜽䝻䜰䝺䜲ἲ䛻䛒䛳䛶䛿䚸㠀≉␗ⓗ䛺⤖ྜ䜢పῶ䛥䛫䜛䛯䜑䛻⏝䛔䜛
Blocking 䛸䛧䛶䛾 BSA 䛜ጉᐖⓗ䛻ാ䛝䚸ṇ☜䛺⤖ྜ䝅䜾䝘䝹䜢ᚓ䜛䛣䛸䜢ᅔ㞴䛸䛥
䛫䛶䛔䛯䚹䛭䛣䛷䚸ᮏ◊✲䛷䛿䚸䜎䛪䚸A ᆺ㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇 HA 䝍䞁䝟䜽㉁䛾
ㄆ㆑䛩䜛䝅䜰䝹㓟ྵ᭷⢾㙐䛾㆑ู䜢ྍ⬟䛸䛩䜛⢾㙐䝬䜲䜽䝻䜰䝺䜲⣔䛾ᨵⰋ䜢⾜䛳
䛯䚹
㻌 䛭䛾⤖ᯝ䚸Blocking 䛾⢾㙐䝬䜲䜽䝻䜰䝺䜲ᢏ⾡䜢ᛂ⏝䛧䛶䚸⢾㙐ㄆ㆑䝍䞁䝟䜽㉁䛾
⤖ྜ䛩䜛ච⣔䜔ᮎᲈ⚄⤒⣔⣽⬊⾲㠃䛻Ⓨ⌧䛥䜜䜛 CD24 ୖ䛾⢾㙐ᵓ㐀䛾ከᵝᛶ䜢
᫂䜙䛛䛻䛩䜛䚹BSA 䜢 PVP 䛻᭰䛘䜛䛣䛸䛻䜘䜚ṇ☜䛺⢾㙐⤖ྜ䝅䜾䝘䝹䛜ᚓ䜙䜜䜛䛣䛸
䛜♧䛥䜜䛯䚹䛣䛾ᡂᯝ䛿䚸2009 ᖺ 10 ᭶䛻⚄ᡞ䛷㛤ദ䛥䜜䛯➨ 82 ᅇ᪥ᮏ⏕Ꮫ
䚸䛚䜘䜃䚸2009 ᖺ 11 ᭶䛻䝥䜶䝹䝖䝸䝁䛷㛤ദ䛥䜜䛯 20 ᅇ ᅜ㝿」ྜ⢾㉁䝅䞁䝫䝆䜴
䝮䛻䛶Ⓨ⾲䛧䛯䚹䛭䛣䛷䚸ᚓ䜙䜜䜛㝈䜚䛾ᵝ䚻䛺䝅䜰䝹㓟ྵ᭷⢾㙐䜢 neoglycolipid 䛧
䛶䝬䜲䜽䝻䜰䝺䜲ศᯒ䜢⾜䛳䛯䚹䛧䛛䛧䛺䛜䜙䚸䛣䛾◊✲䛾㐣⛬䛻䛒䛳䛶䚸ⱥᅜ Imperial
College 䛾 Ten Feizi 䜙䛻䜘䛳䛶䚸㫽ᆺ䛸䝠䝖ᆺ HA 䝍䞁䝟䜽㉁䛾ㄆ㆑䛩䜛ヲ⣽䛺⢾㙐ᵓ
㐀䜢䚸ᙼ䜙䛜⊂⮬䛻ᨵⰋ䛧䛯⢾㙐䝬䜲䜽䝻䜰䝺䜲ἲ䛻䜘䛳䛶⥙⨶ⓗ䛻᫂䜙䛛䛻䛥䜜䚸䛣
䛾◊✲䝔䞊䝬䜢⥅⥆䛩䜛ព⩏䛜ኻ䜟䜜䛶䛧䜎䛳䛯䚹
㻌 䛭䛣䛷䚸⢾㙐䝬䜲䜽䝻䜰䝺䜲ᢏ⾡䜢⥅⥆䛧䛴䛴◊✲┠ᶆ䜢ኚ䛧䚸HA 䝍䞁䝟䜽㉁䛾ㄆ
㆑䛩䜛䝅䜰䝹㓟ྵ᭷⢾㙐䜢ㄆ㆑䛩䜛䝍䞁䝟䜽㉁䛾 1 䛴䛸䛧䛶䚸ච⣔䜔ᮎᲈ⚄⤒⣔⣽
⬊⾲㠃䛻Ⓨ⌧䛥䜜䜛䝅䜰䝹㓟ྵ㔞䛻ᐩ䜐 CD24 ศᏊୖ䛾⢾㙐ᵓ㐀䛾ゎᯒ䜢⾜䛖䛣䛸䛻
䛧䛯䚹䛭䜜䛿䚸䛣䜜䜎䛷䛾⢾㙐◊✲䛛䜙䚸ᮎᲈ⚄⤒⣔䛾䝰䝕䝹⣽⬊䛷䛒䜛 PC12 ⣽⬊
䛾⚄⤒✺㉳ᙧᡂ䛻㛵䜟䜛䝫䝸䝷䜽䝖䝃䝭䞁㙐䛾◊✲䛛䜙䚸䝫䝸䝷䜽䝖䝃䝭䞁㙐䜢ྵ᭷䛩䜛
CD24 䛿䝮䝏䞁ᆺ䛾䝅䜰䝹㓟ྵ᭷⢾㙐䛻ᐩ䜐 GPI 䜰䞁䜹䞊ᆺ䛾䝍䞁䝟䜽㉁䛷䛒䜚䚸⚄
⤒⣔⣽⬊䛾䜏䛺ච⣔䛾ᮍᡂ⇍ B ⣽⬊⾲㠃䛻Ⓨ⌧䛥䜜䚸䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇ឤ
ᰁ䛻䜘䜚ච䜢㉳䛣䛥䛫䜛ᶆⓗ⣽⬊䛾 1 䛴䛻䛺䜛䛸⪃䛘䛯䛛䜙䛷䛒䜛䚹CD24 䛻㛵
䛧䛶䛿䚸䝷䝑䝖 CD24 䛻ᑐ䛩䜛䝰䝜䜽䝻䞊䝘䝹ᢠయ䛜ᕷ㈍䛥䜜䛶䛚䜚䚸᳨ฟ䛜ᐜ᫆䛷䛒䛳
䛯䛜䚸ᢠయ䜹䝷䝮䛺䛹䜢⏝䛔䛶ศ㞳䛩䜛䛣䛸䛿ᅔ㞴䛷䛒䛳䛯䚹䛭䛣䛷䚸GPI 䜰䞁䜹䞊ᆺ
䛷⢾㙐䛻ᐩ䜐ᛶ㉁䛜⢾⬡㉁䛻Ꮫⓗ䛻㢮ఝ䛩䜛䛸⪃䛘䚸⢾⬡㉁䛾ᇶᮏⓗ䛺ศ㞳ἲ䛷
⢭〇䛷䛝䜛ྍ⬟ᛶ䛜䛒䜛䛸⪃䛘䛯䚹
㻌 䛭䛾⤖ᯝ䚸䝷䝑䝖䛾 CD24 䛿䚸ᇵ㣴⣽⬊䛾 PC12 ⣽⬊䛾䜏䛺䜙䛪䚸୰ᯡ⚄⤒⣔䛾⬻䚸
ච⣔䛾㦵㧊⤌⧊䛛䜙䜒ຠ⋡䜘䛟ศ㞳⢭〇䛩䜛䛣䛸䛜䛷䛝䛯䚹䛣䛾◊✲ᡂᯝ䛾୍㒊䛻
䛴䛔䛶䛿䚸㻌 2011 ᖺ 8 ᭶䛻䜸䞊䝇䝖䝸䜰䛷㛤ദ䛥䜜䛯➨ 21 ᅇ ᅜ㝿」ྜ⢾㉁䝅䞁䝫䝆
䜴䝮䛻䛶Ⓨ⾲䛧䛯䚹㻌
㻌 䛭䛣䛷䚸A ᆺ㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ឤᰁ䛻䜘䜚䝙䝽䝖䝸䛜Ṛஸ䛩䜛ཎᅉ䛾୍䛴䛸
䛧䛶䚸䝙䝽䝖䝸䛷䛿䜴䜲䝹䝇䛾ឤᰁ䛜྾ჾᐁ䛷䛿䛺䛟ᾘჾᐁ䛸䛥䜜䜛䛣䛸䛛䜙䚸⤖⭠
䛾ᮎ➃䛻㛤ཱྀ䛩䜛 Fabricius ᄞ䛿ឤᰁ⤌⧊䛸䛺䜚䛖䜛䛸⪃䛘䛯䚹䝙䝽䝖䝸䛷䛿䚸B ⣽⬊䛾
Ⓨ⏕䛿䚸⬇ᮇ䛻༸㯤ᄞ䡡⫢⮚䡡㦵㧊䛛䜙⛣ධ䛧䛶䛝䛯䠞๓㥑⣽⬊䛜 Fabricius ᄞෆ䛷ศ
ቑṪ䛧䛶䠞⣽⬊䛸䛺䜚䚸䛭䛾ᚋ䚸⭁⮚䛺䛹䛾ḟ䝸䞁䝟⣔⤌⧊䜈ศᕸ䛩䜛䚹့ங㢮䛺
−56−
䛹䛷䛿㦵㧊୰䛷㐀⾑ᖿ⣽⬊䛛䜙 B ⣽⬊䜎䛷䛾ศቑṪ䛾㐣⛬䛜㐍⾜䛩䜛䛾䛻ᑐ䛧
䛶䚸㫽㢮䛷䛿㦵㧊୰䛷 B ⣔ิ䜈䛾Ỵᐃ䜎䛷䛜⾜䜟䜜䠈B ๓㥑⣽⬊䛸䛺䜚䝣䜯䝤䝸䜻䜴䝇
ᄞ䜈⛣⾜䛩䜛䛸䛥䜜䛶䛔䜛䛛䜙䛷䛒䜛䚹CD24 䛾䜰䝭䝜㓟㓄ิ䛿䚸䝠䝖䚸䝬䜴䝇䚸䝷䝑䝖䚸䜴
䝃䜼㛫䛷Ⰻ䛟ಖᏑ䛥䜜䚸䝙䝽䝖䝸 CD24 䛾䛭䜜䜒䚸Gallus gallus finished cDNA, clone
ChEST387i20 䛸䛧䛶グ㍕䛥䜜䛯 DNA ሷᇶ㓄ิ䛛䜙䚸32 ಶ䛾䜰䝭䝜㓟㓄ิ䛛䜙䜎䜛 GPI
䜰䞁䜹䞊ᆺ䛾䝍䞁䝟䜽㉁䛷䛒䜛䛸᥎ᐃ䛥䜜䛯䚹
㻌 䛭䛣䛷䚸䝙䝽䝖䝸 CD24 䛾᳨ฟ䛾䛯䜑䛻ᢠయ䛾స〇䜢⾜䛳䛯䚹䛩䛺䜟䛱䚸᥎ᐃ䛥䜜䜛䜰
䝭䝜㓟㓄ิ䛛䜙䚸චື≀䛸䛧䛶䛾䜴䝃䜼䛾 CD24 䜰䝭䝜㓟㓄ิ䛸␗䛺䜛⟠ᡤ䛸䛧䛶䚸11
ಶ䛾䜰䝭䝜㓟㓄ิ䠄TLPAAVNSLNS䠅䜢㑅ᢥ䛧䚸keyhole limpet hemocyanin䠄KHL䠅䛻⤖
ྜ䛥䛫ᢠ⾑Ύ䜢ᚓ䛯䚹ᚓ䜙䜜䛯ᢠ⾑Ύ䛿䝙䝽䝖䝸 Fabricius ᄞ䛾 B ๓㥑⣽⬊䛜Ꮡᅾ䛩䜛
䛸䛥䜜䜛࿘㎶㒊䜢චᰁⰍ䛧䚸චᏛⓗ䛻䝙䝽䝖䝸 CD24 䜢≉ᐃ䛷䛝䜛䛸᥎ᐹ䛷䛝䛯䚹䛭
䛣䛷䚸Western blot ἲ䛻䜘䛳䛶䚸䝷䝑䝖䛾 CD24 䛷ᚓ䜙䜜䛯≉ᛶ䜢䝙䝽䝖䝸 CD24 䜒᭷䛩䜛
䛛䛹䛖䛛䜢ㄪ䜉䛯䚹
㻌 䛸䛣䜝䛜䚸䝣䜯䝤䝸䜻䜴䝇ᄞ䛻䛚䛡䜛 B ๓㥑⣽⬊ᩘ䛾ྜ䛜ᴟᗘ䛻ᑡ䛺䛛䛳䛯䛯䜑䛸
ᛮ䜟䜜䜛䛜䚸CD24 䛾Ꮡᅾ䜢ドᣐ䛵䛡䜛䝞䞁䝗䛸䛧䛶᳨ฟ䛩䜛䛣䛸䛜䛷䛝䛺䛛䛳䛯䚹䜎䛯䚸
䝙䝽䝖䝸୰ᯡ⚄⤒⣔䛾⬻⤌⧊䜢⏝䛔䛶䜒䝷䝑䝖䛷ᚓ䜙䜜䛯䛸ྠᵝ䛺⤖ᯝ䛿ᚓ䜙䜜䛺䛛
䛳䛯䚹䛭䛾ཎᅉ䛾୍䛴䛸䛧䛶 CD24 ྵ㔞䛜䝷䝑䝖䛻ẚ㍑䛧䛶┦ᑐⓗ䛻ప䛔䛸⪃䛘䚸⢾⬡
㉁䛾ᢳฟ䛻‽䛨䛶⢭〇䛷䛝䜛䝷䝑䝖 CD24 䛾ศ㞳ἲ䛻‽䛨䛶䚸䝙䝽䝖䝸䛾䝣䜯䝤䝸䜻䜴䝇
ᄞ䛚䜘䜃⬻⤌⧊䛛䜙䛾䝙䝽䝖䝸 CD24 䛾⢭〇䜢ヨ䜏䛯䚹䝙䝽䝖䝸 CD24 ศᏊୖ䛻䛿 32 ṧ
ᇶ䛛䜙䛺䜛䜰䝭䝜㓟㓄ิ䛾䛖䛱䚸N-ᆺ⢾㙐䛿䝷䝑䝖䚸䝠䝖䛸ྠ䛨䛷 3 䛛ᡤ䚹䝮䝏䞁ᆺ⢾㙐䛾
⤖ྜ䛩䜛䛸⪃䛘䜙䜜䜛䝉䝸䞁䞉䝇䝺䜸䝙䞁ṧᇶ䛾ᩘ䛿 13 ಶ䛸䝷䝑䝖䛾 10 ಶ䜘䜚䜒ከ䛟䚸⢾
⬡㉁䛾ᢳฟ䛻‽䛨䛯᭷ᶵ⁐፹⣔䛷ᢳฟ䛥䜜䚸䛾䝍䞁䝟䜽㉁䛛䜙ຠ⋡䜘䛟ศ㞳䛥䜜䜛䛸
⪃䛘䛯䛛䜙䛷䛒䛳䛯䚹
㻌 䛸䛣䜝䛜䚸᭷ᶵ⁐፹⣔䜢⏝䛔䛶ᢳฟ䛥䜜䛯⏬ศ䜢 Western blot ἲ䛻䜘䛳䛶 CD24 䜢᳨
ฟ䛩䜛䛸ᢠయ䛾⤖ྜ䛩䜛䝞䞁䝗䛜䛟᳨ฟ䛥䜜䛺䛛䛳䛯䚹䛣䛾⤖ᯝ䛿䚸CD24 ศᏊୖ䛻䚸
䛿䛯䛧䛶 A ᆺ㫽䜲䞁䝣䝹䜶䞁䝄䜴䜲䝹䝇䛾ឤᰁ䛻㛵䜟䜛 HA 䝍䞁䝟䜽㉁䛾ཷᐜయ䛷䛒
䜛α2,3 ⤖ྜ䛧䛯䝅䜰䝹㓟䜢䜒䛴⢾㙐ᵓ㐀䛜Ꮡᅾ䛩䜛䛾䛛䛹䛖䛛䜢ㄪ䜉䜛䛣䛸䜢ྍ⬟
䛸䛧䚸ᚋ䛾ㄢ㢟䛸䛧䛶ṧ䛥䜜䛯䚹
㻌 䜎䛯䚸䝅䜰䝹㓟ṧᇶ䜢ㄆ㆑䛩䜛⢾㙐䝬䜲䜽䝻䜰䝺䜲䛾་⒪ᢏ⾡㠃䜈䛾ᛂ⏝䛸䛧䛶䚸⫶
₽⒆䜔⫶⒴䛾ཎᅉ⳦䛸䛥䜜䜛䝢䝻䝸⳦䛾⤖ྜ䛩䜛䝅䜰䝹⢾㙐䛾᳨⣴䜢⾜䛺䛖ணᐃ䛷
䛒䛳䛯䛜䚸䝢䝻䝸⳦䛜ཎᛶ⳦䛸䛧䛶ᢅ䛖䛣䛸䛜ᣦᐃ䛥䜜䚸◊✲ᐊ䛷䛾ᇵ㣴䛜ྍ⬟䛷
䛒䛳䛯䛯䜑䛻◊✲䜢᩿ᛕ䛫䛦䜛䜢ᚓ䛺䛛䛳䛯䚹䝢䝻䝸⳦䛾⳦య⾲㠃䛻䛿ᐟ⣽⬊⾲㠃
䜈䛾᥋╔䛸ዲ୰⌫䛾άᛶㄏᑟ䛻㛵䜟䜛䛸䛥䜜䜛⢾㙐ㄆ㆑䝍䞁䝟䜽㉁䠄BabA䚸SabA䚸
NP-NAP䠅䛜Ꮡᅾ䛧䚸≉䛻 SabA䚸NP-NAP 䛿䝅䜰䝹㓟ṧᇶ䜢㆑ู䛩䜛ཷᐜయ䝍䞁䝟䜽
㉁䛷䛒䜛䚹
㻌 䝢䝻䝸⳦䛻䛿ᛶ㉁䛾␗䛺䜛ኚ␗య䛜▱䜙䜜䛶䛔䜛䛣䛸䛛䜙䚸⢾䝢䝻䝸⳦䛾⳦య⾲㠃䛻
䛿ᐟ⣽⬊⾲㠃䜈䛾᥋╔䛸ዲ୰⌫䛾άᛶㄏᑟ䛻㛵䜟䜛䛸䛥䜜䜛⢾㙐ㄆ㆑䝍䞁䝟䜽
㉁䠄BabA䚸SabA䚸NP-NAP䠅䛜Ꮡᅾ䛧䚸≉䛻 SabA䚸NP-NAP 䛿䝅䜰䝹㓟ṧᇶ䜢㆑ู䛩
䜛ཷᐜయ䝍䞁䝟䜽㉁䛷䛒䜛䚹䝢䝻䝸⳦䛻䛿ᛶ㉁䛾␗䛺䜛ኚ␗య䛜▱䜙䜜䛶䛔䜛䛣䛸䛛䜙䚸
⢾㙐䜈䛾┦స⏝䛻㐪䛔䛻䜘䛳䛶䝢䝻䝸⳦䛾ศ㢮䛜ྍ⬟䛻䛺䜛䛸⪃䛘䛶䛔䛯䛾䛷ṧᛕ
䛷䛒䛳䛯䚹
−57−
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢᐟචᶵ⬟ࡢᙳ㡪
➉ෆ ᐇ
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊ື≀⏕་⛉Ꮫ⛉
࢘ࣝࢫࡢឤᰁࢆཷࡅࡿ⏕యഃࡽࡢ◊✲ࡶ㐍ᒎࡋࡓࠋ⫵ࡢච⣔࠾ࡅࡿ⫵
⬊࣐ࢡࣟࣇ࣮ࢪࡢ࡞ᶵ⬟ࡣࠊ࢘ࣝࢫࡸ⣽⳦ឤᰁࡢึᮇ㜵ᚚᶵ⬟࡛࠶ࡿ㈎㣗
స⏝ࠊࡢච⣔⣽⬊ࢆάᛶࡉࡏࡿࢧࢺ࢝ࣥࡢ⏘⏕ࠊT ⣽⬊ࡢᢠཎᥦ♧
ᶵ⬟࡛࠶ࡾࠊ⫵࡛ࡢ࢘ࣝࢫ࣭⣽⳦ឤᰁᑐࡋ࡚ឤᰁ㜵ᚚࡢ୰ᚰⓗ࡞ᙺࢆࡋ࡚
࠸ࡿࠋႚ↮ࡣࠊච⣽⬊ࡢᶵ⬟ᙳ㡪ࡍࡿࡇࡀ▱ࡽࢀ࡚࠾ࡾࠊᢠ⭘⒆⣽⬊άᛶ
ࡢపୗࠊB ⣽⬊ࡢ LPS ᛂࡢቑຍࠊCon A ࡀㄏᑟࡍࡿ IL㸫㸰⏘⏕ࡢῶᑡཬࡧ T ⣽
⬊ࡢ MLR ᛂࡢῶᑡ࡞ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋ
ࡋࡋࠊႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ࢘ࣝࢫࠊ⣽⳦ࡢឤᰁ㜵ᚚᶵ⬟ᢠ
య⏘⏕ࡢ┦㛵ಀཬࡰࡍᙳ㡪㛵ࡋ࡚ࠊ
ヲ⣽࡞ሗ࿌ࡣᑡ࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋ
ࡑࡇ࡛ࠊႚ↮ࡼࡿ࢘ࣝࢫ࣭ᚤ⏕≀࡞ࡢእ᮶ᢠཎᑐࡍࡿ⫵⬊࣐ࢡࣟࣇ࣮
ࢪࡢ㈎㣗ᶵ⬟ࡑࡢᚋࡢᢠయ⏘⏕ࡢᙳ㡪ࢆㄪࡿࡓࡵࠊ⨺㉥⾑⌫㸦SRBC㸧
ࢆᢠཎࡋ࡚⏝࠸᳨࡚ウࡋࡓࠋ
ࡑࡢ⤖ᯝࠊ㠀ႚ↮⩌ẚ㍑ࡋ࡚ࠊႚ↮⩌ࡢ⫵⬊࣐ࢡࣟࣇ࣮ࢪ࡛ࡣᢠཎࡢྲྀࡾ
㎸ࡳᶵ⬟࡛࠶ࡿ㈎㣗స⏝ࡢᢚไࡀㄆࡵࡽࢀࠊࡑࡢᢚไࡣ㣗స⏝㛵㐃ࡋࡓᢠయࡢ
࢜ࣉࢯࢽࣥࣞࢭࣉࢱ࣮࡛ࡣ࡞ࡃࠊ⿵యࡢ࢜ࣉࢯࢽࣥࣞࢭࣉࢱ࣮ࡢⓎ⌧పୗࡼࡿ
ྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊႚ↮᭚㟢ࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡣࠊᢠయ⏘⏕ࡢ
ึᮇ㐣⛬࡛࠶ࡿᮍ⇍࡞㹀⣽⬊ᶵ⬟ᑐࡋ࡚ᢚไⓗാࡁࠊ᪤ᢠయࢆ⏘⏕ࡋ࡚࠸
ࡿᡂ⇍ࡋࡓ㹀⣽⬊ࡣࠊᢚไⓗ࡞ᙳ㡪ࢆ♧ࡉ࡞ࡗࡓࠋ
ࡇࢀࡽࡢᡂ⦼ࡽࠊႚ↮ࡣ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢᢠཎྲྀࡾ㎸ࡳ㛵ಀࡋࡓ㈎㣗
άᛶࠊ
ࡑࢀᘬࡁ⥆࠸࡚㉳ࡇࡿᮍ⇍㹀⣽⬊ࡢᢠయ⏘⏕ࡢึᮇ㐣⛬ᢚไⓗാࡁࠊ
ࡑࡢ⤖ᯝᢠయ⏘⏕ࢆᢚไࡋ࢘ࣝࢫ࣭⣽⳦࡞ࡢ᫆ឤᰁᛶࢆቑຍࡉࡏࡿྍ⬟ᛶࡀ
♧၀ࡉࢀࡓࠋႚ↮ࡼࡾᶵ⬟ⓗᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡀㄏᑟࡉࢀࡓࠋ
ࡲࡓࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ H1N1 ᰴឤᰁࡼࡾࠊ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ⣽⬊
ෆᵓ㐀ࡢയᐖࡀほᐹࡉࢀࡓࠋࡲࡓࠊ⻏⻤ࠊ࢟ࣀࢥᢳฟᾮ⫵⬊࣐ࢡࣟࣇ࣮ࢪࠊ
⫵ㄏᑟࡉࢀࡓዲ୰⌫ᶵ⬟ࢆάᛶࡉࡏࡿస⏝ࡀ࠶ࡿࡇࡀㄆࡵࡽࢀࡓࠋ
ᮏ◊✲ࡽࠊႚ↮ࡼࡾ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡽάᛶ㓟⣲ࡢ㐣⏘⏕ࡀᘬࡁ㉳
ࡇࡉࢀࠊ⏘⏕ࡉࢀࡓ㐣࡞άᛶ㓟⣲ࡼࡾࠊ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢචᶵ⬟ࡀᢚ
ไࡉࢀࡿࡇࡀ᫂ࡽ࡞ࡗࡓࠋࡇࡢචᶵ⬟ࡢᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪ
ࡀㄏᑟࡉࢀࠊᶵ⬟ⓗᢚไࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡣࠊᘬࡁ⥆ࡃචᛂࢆᢚ
ไࡋࠊ≉ T ⣽⬊࡛ࡣ࡞ࡃᮍ⇍࡞㹀⣽⬊ࡢᢠయ⏘⏕ࡢึᮇㄏᑟᮇస⏝ࡋࠊ⤖ᯝ
ⓗᢠయ⏘⏕ࢆᢚไࡍࡿࡇࡀド᫂ࡉࢀࡓࠋࡉࡽࠊ⻏⻤࢘ࣝࢫࠊ⣽⳦ឤᰁ
ࢆ㜵ᚚࡍࡿዲ୰⌫ᶵ⬟ࢆάᛶࡍࡿస⏝ࢆ᳨ฟࡋࡓࡀࠊ௨ୖࡢ㸰Ⅼࡣ≉➹ࡍࡁ
ᡂᯝ࡛࠶ࡿ⪃࠼࡚࠸ࡿࠋ
୍᪉ࠊᙅẘࡢ H5N3 ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᰴឤᰁࡼࡿࠊ⫵⬊࣐ࢡࣟ
ࣇ࣮ࢪάᛶࡢᙳ㡪ࢆ᳨ウࡋࡓࡀࠊࢧࢺ࢝ࣥࡢ⏘⏕ࡣᙳ㡪ࡀㄆࡵࡽࢀ࡞
ࡗࡓࠋᚋࠊච⣽⬊ࢆάᛶࡉࡏࠊᢠ࢘ࣝࢫస⏝ࢆ᭷ࡍࡿ⣲ᮦࡢ㛤Ⓨ➼
−58−
㛵ࡍࡿᛂ⏝◊✲ࡶྲྀࡾ⤌ࡳࡓ࠸ࠋ
ᮏ◊✲ࡽᾋୖࡋࡓㄢ㢟ࡋ࡚ࠊႚ↮ࡼࡾㄏᑟࡉࢀࡓ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ
㑇ఏᏊኚ␗㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࢆ⏝࠸࡚ࡢឤᰁᐇ㦂ࡀᮍᐇ࡛࠶ࡗࡓࡇ
ࡀ࠶ࡆࡽࢀࡿࠋࡇࡢㄢ㢟ࡘ࠸࡚ࡣࠊ㹁㹅㹆ἲࢆ⏝࠸࡚◊✲ࢆ㐍ࡵࡓ࠸ࠋឤᰁ
ᐇ㦂ࡘ࠸࡚ࡶࠊᮏᏛ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮ᩚഛࡉࢀࡓ P2ࠊ3 タࢆ
⏝࠸࡚⾜࠺ࡇࢆணᐃࡋ࡚࠸ࡿࠋ
୍᪉ࠊႚ↮ࡼࡾㄏᑟࡉࢀࡓᢚไᛶ⫵⬊࣐ࢡࣟࣇ࣮ࢪࢆࡋ࡚ࣥࣇ࢚ࣝࣥ
ࢨ࢘ࣝࢫឤᰁࡀࡢࡼ࠺㐍ᒎࡍࡿࡢࠊࡲࡓ⻏⻤ࠊ࢟ࣀࢥᢳฟᾮࡼࡾࠊච
⣽⬊ࢆࡍࡿ࢘ࣝࢫឤᰁ㜵ᚚࡀྍ⬟࡞ࡿࡢࠊヲ⣽࡞ឤᰁᐇ㦂ࢆ⾜࠸ࠊᇶ
♏◊✲ࡽᛂ⏝◊✲㐍ࡳࠊච⣽⬊ࢆ⏝࠸࡚ࡢᢠ࢘ࣝࢫ⸆ࡢ㛤Ⓨࢆ㐍ࡵ࡚
࠸ࡃணᐃ࡛࠶ࡿࠋࡲࡓࠊᐇ㦂ⓗᙉẘࡋࡓ H5N3 ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝ
ࢫᰴࢆ⏝࠸࡚ࡢ᳨ウࡶᕼᮃࡋ࡚࠸ࡿࠋ
−59−
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⚄⤒ᣦྥᛶᐟᅉᏊࡋ࡚ࡢ⥺⥔ⱆ⣽⬊
ቑṪᅉᏊཷᐜయ
ΎỈ ⏨ࠊᑎ⏣ ᇶ๛ࠊᒸᮏἋ▮㤶ࠊ℩ᑿ ⨾㕥
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊⏕ࢩࢫࢸ࣒Ꮫ⛉
せ᪨
㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀ㑇ఏᏊኚ␗ࡼࡾࠊ⚄⤒ྥᛶࢆ⋓ᚓࡍࡿ࣓࢝ࢽࢬ࣒
ࢆ᫂ࡽࡍࡿࠋᵳࡽࡣࠊᓥ᰿┴࠾࠸࡚ H5N3 ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ
ࢆࢥࣁࢡࢳࣙ࢘⣅ࡽศ㞳ࡋࡓࠋH5N3 ளᆺࡣ㭜ᑐࡋ࡚ᙅẘᛶ㸦ឤᰁࡋ࡚ࡶ㍍ᗘ
ࡶࡋࡃࡣ≧ࡀぢࡽࢀ࡞࠸㸧࡛࠶ࡿࡀࠊ㭜ࣄࢼ⥅௦ࡼࡗ࡚ᙉẘᛶ㸦㭜⮴Ṛᛶ㸧
ኚ␗ࡋࡓࠋᙉẘᰴࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿ㭜ࡢ⮴Ṛཎᅉࡢ୍ࡘࡋ࡚ࠊ྾ჾ㞀
ᐖࢆక࠺✺↛Ṛ࡛࠶ࡿࡇࡽ୰ᯡ⚄⤒⣽⬊ࡢឤᰁࡀ⪃࠼ࡽࢀࡓࠋ⌧ᅾࡲ࡛㫽
ࣥࣇ࢚ࣝࣥࢨࡢ⚄⤒⣽⬊ࡢឤᰁཬࡧࡑࢀࡼࡿᙳ㡪㛵ࡍࡿሗ࿌ࡣࢇࡉ
ࢀ࡚࠸࡞࠸ࠋ㫽㢮ࠊ࠾ࡼࡧங㢮ࡢᡂయ⚄⤒⣽⬊ࡢࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤ
ᰁ࣓࢝ࢽࢬ࣒࠾ࡼࡧ⣽⬊ෆ࠾ࡅࡿቑṪ࣓࢝ࢽࢬ࣒ࡘ࠸࡚ࡶ᫂ࡽࡉࢀ࡚࠸࡞
࠸ࡲࡲ࡛࠶ࡿࠋ
ᮏ◊✲࠾ࡅࡿ᭱⤊┠ⓗࡣࠊ
ᙉẘᰴࡀ⚄⤒⣽⬊ࡢᣦྥᛶࢆ⋓ᚓࡋࠊ
ࡉࡽ㭜ಶయࢆ⮴Ṛࡉࡏࡿ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽࡍࡿࡇ࡛࠶ࡿࠋ
⚄⤒㍈⣴࢞ࢲࣥࢫศᏊࡼࡤࢀࡿࢱࣥࣃࢡ㉁ࡣࠊ⚄⤒㍈⣴Ⓨ⌧ࡍࡿࣞࢭࣉࢱ
࣮ࢆࡋ࡚ࠊ⚄⤒㍈⣴ㄏᅉࡲࡓࡣⓎࢩࢢࢼࣝࢆఏ㐩ࡍࡿࠋ⥺⥔ⱆ⣽⬊ቑṪᅉᏊ
(FGF)ࡣ㫽࠾ࡼࡧ့ங㢮ື≀ࡢ୰ᯡ⚄⤒Ⓨ⌧ࡋࠊ⚄⤒㍈⣴ࢆఙ㛗ࠊㄏᘬࡍࡿࢩࢢ
ࢼࣝࢆ㍈⣴ఏ㐩ࡍࡿࠋFGF ࡢࢩࢢࢼࣝࢆ⣽⬊ෆఏ㐩ࡍࡿཷᐜయ FGFR1 ࡣࠊ୰
ᯡ⚄⤒⣔ࡢⓎ⏕ࠊ⚄⤒ᖿ⣽⬊ࡢቑṪศࢆไᚚࡋ୰ᯡ⚄⤒ࡢᶵ⬟ࢆ⥔ᣢࡍࡿࡓࡵ
≉㔜せ࡞ᙺࢆᯝࡓࡋ࡚࠸ࡿࠋ௨๓ࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁ」〇ࢆ
ಁ㐍ࡍࡿ⣽⬊ᅉᏊࡋ࡚ࠊFGFR ࡀሗ࿌ࡉࢀ࡚࠸ࡿ(Koenig et al., 2010)ࠋᡃࠎࡣࠊ୰
ᯡ⚄⤒⣽⬊Ⓨ⌧ࡍࡿ FGFR1 ࡀࠊᙉẘᛶ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⚄⤒⣽⬊
ࡢឤᰁ㛵㐃ࡍࡿᐟ⣽⬊ഃࡢ㔜せ࡞ᅉᏊ࡛࠶ࡿ௬ㄝࢆ❧࡚ࠊFGFR1 ࡢᶵ⬟ࡢゎ
ᯒࢆ⾜ࡗࡓࠋ
FGFR1 ࡢ⣽⬊እ㡿ᇦࡣࢩࢵࢻ࣎ࢵࢡࢫࡤࢀࡿ㓟ᛶ࣑ࣀ㓟ᐩࢇࡔࢻ
࣓ࣥࡀᏑᅾࡍࡿࠋࢩࢵࢻ࣎ࢵࢡࢫࡣ FGF-FGFR ࡢࢩࢢࢼࣝࢆ⣽⬊ෆఏ㐩ࡍࡿ
㔜せ࡞⣽⬊እࢻ࣓࡛ࣥ࠶ࡿ(Shimizu A., et al. 2001) ࠋFGFR1 ࡢࢩࢵࢻ࣎ࢵࢡࢫ
ᶵ⬟Ḟኻᆺኚ␗࡛࠶ࡿண ࡉࢀࡿ 1 ࣑ࣀ㓟ᤄධኚ␗(D133_D134insD)ࢆᑟධ
ࡋࠊ⚄⤒⣽⬊ࡢᶵ⬟ࡢኚࢆㄪࡓࠋPC12 ⣽⬊ FGFR1 ṇᖖᆺ㸦WT㸧ࡲࡓࡣ FGFR1
ࢩࢵࢻ࣎ࢵࢡࢫኚ␗య㸦FGFR1 mutant㸧ࢆᏳᐃⓎ⌧ࡉࡏࡓࠋFGF2 ࡼࡗ࡚ࠊFGFR1
mutant ࡀㄏᑟࡍࡿ⚄⤒✺㉳ࡢ㛗ࡉࡣ FGFR1 WT ẚ㍑ࡍࡿ▷ࡃ࡞ࡗࡓࡀ᭷ពᕪ
ࡣᚓࡽࢀ࡞ࡗࡓࠋ
ࢡࢳࣥࣇ࣓ࣛࣥࢺᰁⰍᚋඹ↔Ⅼ㢧ᚤ㙾ࢆ⏝࠸࡚ほᐹࡍࡿࠊFGFR1WT
ẚ㍑ࡋ࡚ࠊFGFR1 mutant ࡢㄏᑟࡍࡿ⚄⤒✺㉳ࡣ⣽ࡃࠊ⚄⤒㍈⣴ඛ➃Ꮡᅾࡍࡿᡂ
㛗㗹ࡢ㠃✚ࡶᑠࡉࡗࡓ ࠋ
⚄⤒⣽⬊≉␗ⓗⓎ⌧ࡍࡿ୰㛫ᚄࣇ࣓ࣛࣥࢺ࡛࠶
ࡿࢽ࣮ࣗࣟࣇ࣓ࣛࣥࢺࢆᰁⰍࡍࡿࠊFGFR1 WT ࡢ⚄⤒✺㉳࠾࠸࡚ࡣᙉࡃᰁⰍ
ࡉࢀࡿ୍᪉ࠊFGFR1 mutant ࠾࠸࡚ࡣᙅ࠸ᰁⰍࢆ♧ࡋࠊᡂ㛗㗹ࡣᰁⰍࢆ♧ࡉ࡞
ࡗࡓࠋFGF2 ่⃭ࡼࡿ FGFR1WT mutant ࡢ⣽⬊ෆࢩࢢࢼࣝఏ㐩ࢆẚ㍑ࡋࡓࠋ
−60−
FGF2 ่⃭ࡼࡗ࡚ MAPK(ERK1/2) Akt ࡢࣜࣥ㓟ࡢ⛬ᗘᕪ␗ࡣぢࡽࢀ࡞ࡗ
ࡓࡀࠊPLCȚࡢ FGFR1 mutant ࡢ⤖ྜࡀ FGFR1 WT ẚ㍑ࡋ࡚పࡃ࡞ࡗ࡚࠸ࡓࠋ
FGFR1 WT mutantࡼࡿ⚄⤒✺㉳ఙ㛗ࡢᕪPLCȚࡢ⤒㊰ࡀ㛵ࡋ࡚࠸ࡿࡇࢆ
☜ࡵࡿࡓࡵ㸪 FGFR1 WT ࢆⓎ⌧ࡋ࡚࠸ࡿ⚄⤒⣽⬊ࢆ PLCȚ siRNA ࡛ฎ⌮ࡋࡓࠋ
ࡑࡢ⤖ᯝࠊFGF2 ่⃭ࡼࡗ࡚⣽࠸⚄⤒✺㉳ᑠࡉ࠸ᡂ㛗㗹ࢆㄏᑟࡋࡓࠋ⚄⤒
✺㉳୰ࡢࢽ࣮ࣗࣟࣇ࣓ࣛࣥࢺᰁⰍࡣᙅࡃࠊᡂ㛗㗹࠾࠸࡚ᰁⰍࡣ☜ㄆ࡛ࡁ࡞
ࡗࡓࠋ௨ୖࡢ⤖ᯝࡽࠊFGFR1 ࡢࢩࢵࢻ࣎ࢵࢡࢫࡢኚ␗కࡗࡓ PLCȚࡢࢩࢢࢼ
ࣝࡢపୗࡀࠊ⚄⤒㛫ࡢࢩࢢࢼࣝᙧᡂᙳ㡪ࢆ࠼࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡓࠋᙉẘᛶ
㫽ࣥࣇ࢚ࣝࣥࢨࡢ୰ᯡ⚄⤒ᑐࡍࡿẘᛶࡣࠊ⚄⤒⣽⬊ࡗ࡚㔜せ࡞ࢩࢢࢼࣝࢆ
㜼ᐖࡍࡿࡓࡵ⚄⤒⣽⬊ࡢᶵ⬟㞀ᐖࢆᘬࡁ㉳ࡇࡋ࡚࠸ࡿྍ⬟ᛶࡀ᥎ ࡉࢀࡓࠋ
ᐇ㦂ᴫせ
FGFR1 ࡣ⣽⬊እ㸱ࡘࡢ࣒ࣀࢢࣟࣈࣜࣥᵝࢻ࣓ࣥࢆࡶࡕࠊ⣽⬊ෆࢳࣟࢩࣥ
࢟ࢼ࣮ࢮࢻ࣓ࣥࢆ᭷ࡍࡿࠋFGF ࡀ⣽⬊እࡢ➨㸰␒┠➨㸱␒┠ࡢ࣒ࣀࢢࣟࣈࣜ
ࣥᵝࢻ࣓ࣥ⤖ྜࡍࡿࡇࡼࡗ࡚ࠊ
㔞యࡋࠊ
ୗὶࢩࢢࢼࣝࡀఏ㐩ࡉࢀࡿࠋ
ࡑࡢ⣽⬊እࡢ࣒ࣀࢢࣟࣈࣜࣥᵝࢻ࣓ࣥࡢ㸯㸰ࡢ㛫㓟ᛶ࣑ࣀ㓟ࡀ㐃⥆ࡍࡿ
ࢩࢵࢻ࣎ࢵࢡࢫࡤࢀࡿࢻ࣓ࣥࡣࢩࢢࢼࣝࡢㄪ⠇ࢆᢸࡗ࡚࠸ࡿࠋࢩࢵࢻ࣎
ࢵࢡࢫ(AB) 1 ࣑ࣀ㓟ᤄධኚ␗(D133_D134insD)ࢆᑟධࡋ FGFR1 AB ኚ␗య
㸦FGFR㸯mutant㸧ࢆసᡂࡋࡓࠋ⚄⤒⣽⬊ෆࡢࢩࢢࢼࣝࢆゎᯒࡍࡿࡓࡵࠊ⚄⤒⣽⬊
ឤᰁࡋ┠ⓗ㑇ఏᏊࡢ㐣Ⓨ⌧ࢆㄏᑟࡍࡿࡀฟ᮶ࡿࣞࣥࢳ࢘ࣝࢫࢩࢫࢸ࣒ࢆᵓ
⠏ࡋࡓࠋ
PC12 ⣽⬊ࡣ in vitro ࡢᇵ㣴⣔࡛⚄⤒⣽⬊ࡢศㄏᑟࡀྍ⬟࡞⣽⬊ᰴ࡛࠶ࡿࠋ
FGFR㸯WT ࢆⓎ⌧ࡉࡏࡓ PC12 ⣽⬊ FGF㸰่࡛⃭ࡍࡿࡇࡼࡗ࡚ࠊ⚄⤒⣽⬊
ࡢศㄏᑟ⚄⤒✺㉳ࡢఙ㛗ࢆㄏᑟࡍࡿࡇࡀฟ᮶ࡿࠋ FGFR1 WT FGFR1
mutant ࢆ࢘ࣝࢫ࣋ࢡࢱ࣮ࢆ⏝࠸࡚ PC12 ⣽⬊ឤᰁࡉࡏࠊFGF2 ่⃭ࡼࡿ⚄⤒✺
㉳ఙ㛗ࡢㄏᑟࢆẚ㍑ࡋࡓࠋ⚄⤒✺㉳ࡢ㛗ࡉࢆ WT mutant ࡛ẚ㍑ࡍࡿ᭷ព࡞ᕪࡣ
ㄆࡵࡽࢀࡎࠊྠ⛬ᗘࡢ⚄⤒✺㉳ఙ㛗ࡀㄏᑟࡉࢀࡓࠋ
ࡋࡋࠊAlexaFluor 488 phalloidin ࢆ⏝࠸࡚ࢡࢳࣥࣇ࣓ࣛࣥࢺࢆᰁⰍࡋࠊඹ↔
Ⅼ㢧ᚤ㙾ࡼࡗ࡚ほᐹࡍࡿࠊFGFR1WT ẚ࡚ FGFR1mutant ࡛ࡣ⚄⤒✺㉳ࡀ⣽
࠸ࡇࡀศࡗࡓࠋ⚄⤒✺㉳ࡀ࡞ࡐ⣽ࡃ࡞ࡿࡢࢆㄪࡿࡓࡵ㸪ᚤᑠ⟶㸦tubulin㸧
⚄⤒⣽⬊≉␗ⓗ࡞୰㛫ᚄࣇ࣓ࣛࣥࢺࠊࢽ࣮ࣗࣟࣇ࣓ࣛࣥࢺ(NF160)ࢆᰁⰍ
ࡋࡓࠋᚤᑠ⟶ࢱࣥࣃࢡ㉁ tubulin ࡢⓎ⌧ࡣ FGFR1WT FGFR1mutant ࡛ࡢᕪࡣぢࡽ
ࢀ࡞ࡗࡓࠋFGFR1 WT ࡢ⚄⤒✺㉳ࡣᢠ NF160 ᢠయࡼࡗ࡚ᙉࡃᰁⰍࡉࢀ࡚࠸ࡓࡀࠊ
FGFR1 mutant ࡛ࡣ⚄⤒✺㉳୰ࡢࢽ࣮ࣗࣟࣇ࣓ࣛࣥࢺࡢࢱࣥࣃࢡ㔞ࡀపࡃ࡞ࡗ࡚
࠸ࡓࠋ
ࡉࡽࠊFGFR1 WT ࡢᡂ㛗㗹࠾࠸࡚ࡣ NF160 ࡢᰁⰍࡀㄆࡵࡽࢀࡓࡀࠊmutant
ࡢᡂ㛗㗹࡛ࡣ NF160 ࡢᰁⰍࡣ᳨ฟ࡛ࡁࡎࠊᑠࡉࡃ࡞ࡗ࡚࠸ࡓࠋFGF2 ่⃭ࡼࡿ
FGFR1 WT mutant ࡢ⚄⤒✺㉳ఙ㛗ᚋࠊ⣽⬊ࢆ⁐ゎࡋ࢙࢘ࢫࢱࣥࣈࣟࢵࢺࡼࡾ
NF160 ࡢࢱࣥࣃࢡ㉁ࢆ᳨ฟࡋࡓࠋFGFR1 WT ࠾࠸࡚ NF160 ࢱࣥࣃࢡ㉁ࡣ FGF2
ࡼࡗ࡚Ⓨ⌧ࢆㄏᑟࡉࢀ࡚࠸ࡓࡀࠊFGFR1 mutant ࠾࠸࡚ࡣࠊࢱࣥࣃࢡ㉁Ⓨ⌧ࢆㄏᑟ
ࡉࢀ࡚࠸࡞ࡗࡓࠋNF160 ࡣ⚄⤒✺㉳ࡢኴࡉᙉᗘ㔜せ࡞ᙺࢆᯝࡓࡋ࡚࠸ࡿࡇ
−61−
ࡽࠊFGFR1 ࡢࢩࢵࢻ࣎ࢵࢡࢫࡣࠊ⚄⤒⣽⬊ศࡢ㝿ࡢࢽ࣮ࣗࣟࣇ࣓ࣛࣥࢺ
ࡢⓎ⌧⚄⤒✺㉳ࡢᙉᗘࡢ⥔ᣢ㔜せ࡞ᙺࢆᯝࡓࡋ࡚࠸ࡿࡇࡀ♧၀ࡉࢀࡓࠋ
FGF2 ่⃭ࡼࡿ FGFR1 ࡢ⚄⤒ศ㛵ࢃࡿ⣽⬊ෆࢩࢢࢼࣝఏ㐩ࡣࠊ
MAPK(ERK1/2)ࠊPI3K/AktࠊPLCγ1 ࡢ⤒㊰ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋFGFR1 WT mutant
ࢆⓎ⌧ࡉࡏࡓ PC12 ⣽⬊ࢆ⏝࠸࡚ࠊ10 ng/ml FGF2 ่࡛⃭ࡋ࡚㸮ࠊ5ࠊ30ࠊ60 ศᚋࡢ
⣽⬊ෆࢱࣥࣃࢡ㉁ࢆᅇࡋࠊ
Immunoblot ࡛ Aktࠊ
ERK1/2 ࡢࣜࣥ㓟ࢆ᳨ฟࡋࡓ⤖ᯝࠊ
FGFR1WT mutant 㐪࠸ࡣぢࡽࢀ࡞ࡗࡓࠋFGFR1 WT mutant ࢆ FGF2 ่࡛⃭
ࡋ࡚⣽⬊ෆࢱࣥࣃࢡ㉁ࢆᅇࡋࠊPLCȖ1 ᢠయ࡛චỿ㝆ࢆࡋࡓࠋSDS-PAGEࠊPVDF
⭷㌿ࡋࡓᚋ FGFR1 ᢠయ᳨࡛ฟࡋࡓࠋFGFR1 WT ࡛ࡣ FGF2 ่⃭ᚋ PLCγ1
ࡢ」ྜయࡀᙧᡂࡉࢀ࡚࠸ࡓࡀࠊFGFR1 mutant ࡛ࡣ PLCȖ1 ࡢ」ྜయࡣ᳨ฟ࡛ࡁ࡞
ࡗࡓࠋ
ࡇࡢ⤖ᯝࡼࡾࠊFGFR1 ࡢࢩࢵࢻ࣎ࢵࢡࢫࡣࠊFGFR1 ࡽ⣽⬊ෆࡢ PLCȖ1 ࢩ
ࢢࢼࣝࢆఏ㐩ࡍࡿࡓࡵ㔜せ࡛࠶ࡿࡇࡀ♧၀ࡉࢀࡓࠋ ࡇࢀࢆ☜ㄆࡍࡿࡓࡵࠊ
FGFR1 WT ࢆⓎ⌧ࡋ࡚࠸ࡿ PC12 ⣽⬊ࢆ PLCȖ1siRNA ࡛ฎ⌮ࡋࡓࡢࡕࠊFGF2 ่⃭
ࡼࡗ࡚⚄⤒✺㉳ࡢఙ㛗ࢆゎᯒࡋࡓࠋ
ࡑࡢ⤖ᯝࠊ PLCȖ1siRNA ࡛ฎ⌮ࡋࡓ FGF WT ࡢ⚄⤒✺㉳ࡣࠊFGFR1 mutant ࠾
࠸࡚ほᐹࡉࢀࡿ⚄⤒✺㉳ྠᵝ⣽ࡃ࡞ࡗ࡚࠸ࡓࠋࡋࡋࠊsi control si PLCȖ1 ࡢ
⚄⤒✺㉳ࡢ㛗ࡉ᭷ព࡞ᕪࡣㄆࡵࡽࢀ࡞ࡗࡓࠋPLCȖ1 siRNA ฎ⌮ࢆࡋࡓ FGFR1
WT ࡢ⚄⤒✺㉳࠾࠸࡚ࡶࠊ FGFR1 mutant ࡛ほᐹࡉࢀࡓࡼ࠺ᢠ NF160 ᢠయࡼ
ࡿᰁⰍࡣᙅࡃᡂ㛗㗹ෆࡣᰁⰍࡀㄆࡵࡽࢀࡎࠊఙᒎࡀᑠࡉ࠸ࡶࡢࡀほᐹࡉࢀࡓࠋ
PLCȖ1 siRNA ฎ⌮ࢆࡋࡓ FGFR1 WT ࡢ⚄⤒✺㉳࠾࠸࡚ࡶࠊྠᵝ FGF2 ࡼࡿ
NF160 ࢱࣥࣃࢡ㉁ࡢⓎ⌧ㄏᑟࡣࡉࢀ࡞ࡗࡓࠋ
⤖ㄽ
PLCȖ1 ࡢάᛶࡀࠊࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢឤᰁࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿࡇ
ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸦Chen X-J. et al. 2004㸧ࠋࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡣឤᰁࡼࡗ
࡚ࠊᐟ⣽⬊ࡢ FGFR1 ࡼࡗ࡚άᛶࡉࢀࡿࡁ PLCȖ1 ࡢࢩࢢࢼࣝఏ㐩⤒㊰ࢆ㞀
ᐖࡋࠊ⣽⬊ẘᛶࢆཬࡰࡍࡇࡀ⪃࠼ࡽࢀࡿࠋࡇࡢ◊✲࡛♧ࡋࡓࡼ࠺࡞⌧㇟ࡀᙉẘᛶ
㫽ࣥࣇ࢚ࣝࣥࢨࡢឤᰁࡼࡗ࡚୰ᯡ⚄⤒࠾࠸࡚㉳ࡇࢀࡤࠊ୰ᯡ⚄⤒ࡢࢩࢢࢼࣝ
ఏ㐩⤒㊰ࢆ㜼ᐖࡋ࡚ẘᛶࢆⓎࡍࡿྍ⬟ᛶࡀ࠶ࡿࠋ
ཧ⪃ᩥ⊩
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Inaka, K., Takahashi, S., Aritake, K., Tsurumura, T., Furubayashi, N., Yan, B., Hirota,
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Protein Crystal Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in
Microgravity. Crystal Growth nd Design, 11, 2107-2111, 2011.
Fukui, S. and Kawahara, M. Purification and characterization of CD24, one of major
poly-N-acetyl-lactosamine-carrying glycoproteins, in PC12 cells. Glycoconjugate J.
28, 277-278, 2011.
Koizumi T, Matsumoto-Takasaki A, Nakada H, Nakata M, Fujita-Yamaguchi Y.
Preparation of asialo-agalacto-glycophorin A for screening of anti-Tn antibodies.
Biosci Trends., 4, 308-311, 2011.
Hamaguchi M, Kawahito Y, Ishino H, Takeuchi N, Tokunaga D, Hojo T, Yamamoto A,
Kadoya M, Seno T, Kohno M, Nakada H. 㸸Mucin from rheumatoid arthritis
synovial fluid enhances interleukin-6 production by human peripheral blood
mononuclear cells. Hum Immunol., 72, 241-248, 2011.
Miyahara, E.,Nishie, M., Takumi, S., Miyanohara, H., Nishi, J., Yoshiie, K., Oda, H.,
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mutagens may be implicated in emergence of drug-resistant microorganisms. FEMS
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Imanishi, J., Takeuchi, M., Hisa, Y., and Mazda. O. Interleukin-28B acts
synergistically with cisplatin to suppress the growth of head and neck squamous cell
carcinoma. Journal of Immunotherapy, 34, 139-48, 2011.
Fukuda M, Kobayashi K, Hirono Y, Miyagawa M, Ishida T, Ejiogu EC, Sawai M,
Pinkerton KE, Takeuchi M.㸸Jungle honey enhances immune function and antitumor
activity. Evid Based Complement Alternat Med., 1-7, 2011.
▼⏣ႛ⿱ ➉ෆᐇ㸸ႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࢆࡋࡓᢠཎ≉␗ⓗ࠾ࡼࡧ㠀
≉␗ⓗ࡞ࣜࣥࣃ⌫ቑṪᛂཬࡰࡍᙳ㡪 ி㒔⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ
➨ 40 ྕ, 71-108, 2011.
32
−67−
Imagawa T, Tsurumura T, Sugimoto Y, Aki K, Ishidoh K, Kuramitsu S, Tsuge H.
Structural basis of the free reduced flavin generation by flavin reductase from
Thermus thermophilus HB8. J Biol Chem., 286, 44078-44085, 2011.
Ohtomo H, Konuma T, Utsunomiya H, Tsuge H, Ikeguchi M. Structure and stability of
Gyuba, ș-lactoglobulin chimera. Protein Sci., 20, 1867-1875, 2011.
Yoshida T, Tsuge H, Konno H, Hisabori T, Sugano Y. The catalytic mechanism of
dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic
acid residue. FEBS J., 278, 2387-2394, 2011.
Inaka K, Takahashi S, Aritake K, Tsurumura T, Furubayashi N, Yan B, Hirota E, Sano S,
Sato M, Kobayashi T, Yoshimura Y, Tanaka H, Urade Y. High-Quality Protein
Crystal Growth of Mouse Lipocalin-Type Prostaglandin D Synthase in Microgravity.
Cryst Growth Des., 11, 2107-2111, 2011.
ᕝᮏဴ㑻㸬⋇་⒪࠾ࡅࡿࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺ㸬⏘ἲᏛ㸬44, 1-14, 2010.
ᕝᮏဴ㑻㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨἲᨻ⟇㸬⏘ἲᏛ㸬44, 1-14, 2010.
Watanabe, T., Tsuge, H., Imagawa, T., Kise, D., Hirano, K., Beppu, M., Takahashi, A.,
Yamaguchi, K., Fujiki, H., Suganuma, M. Nucleolin as cell surface receptor for
tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter
pylori. Journal of Cancer Research and Clinical Oncology, 136, 911-921, 2010.
Fujimoto, Y., Ito, H., Shivakoti, S., Nakamori, J., Tsunekuni, R., Otsuki, K., and Ito, T.
Avian influenza virus and paramyxovirus isolation from migratory waterfowl and
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72, 963-967, 2010.
Sakoda Y, Sugar S, Batchluun D, Erdene-Ochir TO, Okamatsu M, Isoda N, Soda K,
Takakuwa H, Tsuda Y, Yamamoto N, Kishida N, Matsuno K, Nakayama E,
Kajihara M, Yokoyama A, Takada A, Sodnomdarjaa R, Kida H.㸸Characterization of
H5N1 highly pathogenic avian influenza virus strains isolated from migratory
waterfowl in Mongolia on the way back from the southern Asia to their northern
territory. Virology, 406, 88-94, 2010.
Murata, H., and Otsuki, K. 㸸Swine influenza and cytokines:less of a sorm, more of a
breeze. Vet. J., 187, 16-17, 2010.
33
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Shivakoti, S., Itoh H., Murase, T., Ono, E., Takakuwa, H., Yamashiro, T., Otsuki, K.,
and Ito, T. 㸸Development of reverse transcription-loop-mediated isothermal
amplification (RT-LAMP) assay for detection of avian influenza viruses in the field
specimens. J. Vet. Med. Sci., 72, 519-523, 2010.
Shivakoti, S., Itoh H., Otsuki, K., and Ito, T. 㸸Characterization of H5N1 highly
pathogenic avian influenza virus isolated from a mountain hawk eagle in Japan. J.
Vet. Med. Sci., 72, 459-463, 2010.
Tsunekuni, R., Ito, H., Kida, H., Otsuki, K., and Ito, T. 㸸Increase in the neuraminidase
activity of a nonpathogenic Newcastle disease virus isolate during passaging in
chickens. J. Vet. Med. Sci., 72, 453-457, 2010.
Tsunekuni, R., Ito, H., Otsuki, K., Kida, H., Ito, T. 㸸Genetic comparisons between
lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants.
Virus Genes. 40, 252-255, 2010.
Takakuwa, H., Yamashiro, T., Le, Q. M., Phuong, L. S., Ozaki, H., Tsunekuni, R., Usui,
T., Ito, H., Yamaguchi, T., Ito, T., Murase, T., Ono, E., Otsuki, K. 㸸Possible
circulation of H5N1 avian influenza viruses in healthy ducks on farms in northern
Vietnam. Microbiol. Immunol ., 54, 58-62, 2010.
Takakuwa, H., Maruoka, T., Hata, T., Miyazawa, M., Hata, T., Toshimori, T., and Otsuki,
K. 㸸Development of a new disinfectant with very strong anti-influenza-viral activity
-a preliminary report. Environ. Health Prev. Med., 15, 121-123. 2010.
Ohta, M., Ishida, A., Toda, M., Akita, K., Inoue, M., Yamashita, K., Watanabe, M.,
Murata, T., Usui, T., Nakada, H.㸸Immunomodulation of monocyte-derived dendritic
cells through ligation of tumor-produced mucins to Siglec-9. Biochem. Biophys. Res.
Commun.,402: 663-669, 2010.
Ishino, H., Kawamoto, Y., Hamaguchi, M., Takeuchi, N., Tokunaga, D., Hojo, T., Wada,
M., Yamamoto, A., Kadoya, M., Tsubouchi, Y., Kohno, M., Nakada, H. Expression
of Tn and sialyl Tn antigens in synovial tissues in rheumatoid arthritis. Clin. Exp.
Rheumatol., 28: 246-249, 2010.
Miyagawa, M., Fukuda, M., Hirono, Y., Kawazoe, A., Shigeyoshi, E., Sakura, M.,
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34
−69−
ᘅ㔝⏤㔛Ꮚ ➉ෆᐇ. ࢱࣂࢥὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ㹂㹌㸿ᦆയࡢㄏ
ᑟ࣏ࢺ࣮ࢩࢫࡢᢚไ ி㒔⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ ➨ 39 ྕ,
63-93, 2010.
Watanabe T, Tsuge H, Imagawa T, Kise D, Hirano K, Beppu M, Takahashi A,
Yamaguchi K, Fujiki H, Suganuma M. Nucleolin as cell surface receptor for tumor
necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori.
J Cancer Res Clin Oncol., 136, 911-21, 2010.
ᕝᮏဴ㑻㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨἲ㸬⏘ἲᏛ㸬43, 1-19, 2009.
⣽㔝㞝୕ࠊᮤ⪷ᯘࠊᮧ⏣ᐂಇ㸬ධ㐣⛬⌧ࢀࡿ㐍⾜Ἴゎࡘ࠸࡚㸬ி㒔Ꮫᩘ
⌮ゎᯒ◊✲ᡤㅮ✲㘓㸬1663, 65-71, 2009.
㧘᱓ᘯᶞ㸪ᖖᅧⰋኴ㸪⸭⏣ῄண㸪୰ᮧಖ⣖㸪ୖ⊛ኵ㸪ᵳබ୍.㸸㸱✀㢮ࡢᚤ㤶
ࡃࢇᾮࡢᢠ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫຠᯝ㸬㜵⳦㜵㰄㸪37, 879-882, 2009
㧘᱓ᘯᶞ㸪ᖖᅧⰋኴ㸪ᵳබ୍㸬
㸸H1 ளᆺࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᑐࡍࡿᾘẘ
⸆ࡢຠᯝ㸬ᐙ␆⾨⏕Ꮫ㞧ㄅ㸪35, 57-58, 2009.
Morita, N., Yajima, Y., Asanuma, H., Nakada, H., Fujita-Yamaguchi, Y.㸸Inhibition of
cancer cell growth by anti-Tn monoclonal antibody MLS128. BioScience Trends,
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Toda, M., Hisano, R., Yurugi, H., Akita, K., Maruyama, K., Inoue, M., Adach, T.,
Tsubata, T., Nakada, H.㸸Ligation of tumor-produced mucins to CD22 dramatically
impairs splenic marginal zone B cells. Biochem. J., 417: 673-683, 2009.
Fukui, S. and M. Kawahara. Rat CD24 is one of major poly-N-acetyllactosamine-carrying glycoproteins in PC12 cells and rat bone marrow, but not in
PC12D cells and rat brain. Glycoconjugate J. 26, 818-819, 2009.
Terada M., Ohnishi, C., Ueno, N., Shimizu, A., Kanai, M., Seo, M. Enhanced expression
of fibroblast growth factor receptor 3 in human skin cancer cells. The Open
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Ishida T, Hirono Y, Yoshikawa K, Hutei Y, Miyagawa M, Sakaguchi I, Pinkerton KE,
Takeuchi M.㸸Inhibition of immunological function mediated DNA damage
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1229-1235, 2009,
35
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Izumo K, Horiuchi M, Komatsu M, Aoyama K, Bandow K, Matsuguchi T, Takeuchi M,
Takeuchi T. 㸸Dehydroepiandrosterone increased oxidative stress in a human cell line
during differentiation. Free Radic Res., 43, 922-9231. 2009.
Ishida T, Pinkerton KE, Takeuchi M. Alveolar macrophage from cigarette smoke-exposed
mice inhibits B lymphocyte proliferation stimulated with LPS. Respiration., 77,
91-95, 2009.
⚟⏣⨾ᶞ ᐑᕝ┿⏤Ꮚ ➉ෆ ᐇ. ࢪࣕࣥࢢࣝࣁࢽ࣮ࡼࡿචᶵ⬟ࡢᙳ㡪
ᢠ⭘⒆స⏝ ி㒔⏘ᴗᏛㄽ㞟 ⮬↛⛉Ꮫ⣔ิ ➨ 38 ྕ, 95-118, 2009.
ᕝᮏဴ㑻㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐࡍࡿᏛࡢྲྀࡾ⤌ࡳ㸬⏘ἲᏛ㸬42, 1-12, 2008.
ᕝᮏဴ㑻㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ேᶒ㸬⏘ἲᏛ㸬41, 66-80, 2008.
Ishida, A., Ohta, M., Toda, M., Murata, T., Usui, T., Akita, K., Inoue, M., Nakada, H.
Mucin-induced apoptosis of monocyte-derived dendritic cells during maturation.
Proteomics, 8, 3342-3349, 2008.
Toda, M., Akita, K., Inoue, M., Taketani, S., Nakada, H.㸸Down-modulation of B cell
signal transduction by ligation of mucins to CD22. Biochem. Biophys. Res.
Commun., 372, 45-50, 2008.
Yu, B., Kodavanti, U.P., Takeuchi, M. Witschi H., and Pinkerton. K.E. Acute Tobacco
Smoke-Induced Airways Inflammation in Spontaneously Hypertensive Rats.
Inhalation toxicology, 20, 623-633, 2008.
ⴭ᭩
ᵳබ୍㸬➨㸰❶ ၟရ⏕⏘ࡲ࡛ࡢㅖつไ ➨ 1 ⠇ ཎᮦᩱࡢᏳ☜ಖࡢࡓࡵ
ࡢつไ 㸲 ᐙ␆ࡢఏᰁ, pp2601-2644, 㣗ࡢᏳ◊✲⦅ ࢩ࣮ࣜࢬ㣗ࡢ
Ᏻ Ᏻ࡞㣗ရࡢຍᕤ〇㐀ࡢࡓࡵࡢࢳ࢙ࢵࢡࣜࢫࢺ㸦㏣㘓 18 ྕ㸧
㸪➨୍ἲ
つ, 2013㸬
ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿2012 ࠥࣃࣥࢹ࣑ࢵࢡ H1N1 2009 ࡢ
⤊↉ࢆ㏄࠼࡚ࠥ㸬
㸸㸷㸬
ࣈࢱࣥࣇ࢚ࣝࣥࢨࡢṔྐࡣ㸽ࡢ㡯┠ࢆᇳ➹ࠊ
㕥ᮌ ᏹࠊ
Ώ㎶ ᙲ⦅ࠊ་⸆ࢪ࣮ࣕࢼࣝ♫㸬㜰㸬2012㸬
ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿 2010㸸㸱㸬ࣈࢱࣥࣇ࢚ࣝࣥࢨࡢṔ
ྐࡣ㸽㸲㸬ࣃࣥࢹ࣑ࢵࢡ㫽ࣥࣇ࢚ࣝࣥࢨࡢᚋࡢ᥎⛣ࡣ㸽ࡢ㸰㡯┠ࢆ
ᇳ➹ࠊ㕥ᮌ ᏹࠊᯇᮏ ୕⦅ࠊ་⸆ࢪ࣮ࣕࢼࣝ♫ࠊ㜰㸬2010.
36
−71−
୰⏣ ༤㸬⒴⣽⬊ࡣචᶵᵓࢆᝏ⏝ࡋ࡚ቑṪࡍࡿࠊ
㸦⊂㸧⛉Ꮫᢏ⾡⯆ᶵᵓ⦅
⢾㙐ࢆ▱ࡿ ࡑࡢ⣲㢦Ẽࡢᣮᡓ㸬 pp98-105,㸦⊂㸧⛉Ꮫᢏ⾡⯆ᶵᵓ,
2010.
ᵳබ୍㸬ࣥࣇ࢚ࣝࣥࢨࡢ᭱᪂▱㆑㹏㸤㸿 2009㸸㸳㸬ᐙ⚺࣌ࢫࢺࡑࡢṔྐ
—࠸ࡘࡇࡢᝈࡀࣥࣇ࢚ࣝࣥࢨࢃࡗࡓࡢ㸽ࡢ㡯┠ࢆᇳ➹ࠊ㕥ᮌ ᏹࠊ
ᯇᮏ୕⦅ࠊ་⸆ࢪ࣮ࣕࢼࣝ♫ࠊ㜰㸬2009㸬
ᵳබ୍㸬࢘ࣝࢫࡀࢧࢡࢵࢃࡿᮏ㸸┘ಟࠊᘅ῭ᇽࠊᮾி㸬2009㸬
Nakada, H. Biological Significance of mucins produced by epithelial cancer cells, in N.
Taniguchi et al. (Eds) Experimental Glycoscience, pp.239-242. Springer, New Yolk,
2008.
ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨࡽᐙ᪘ࢆᏲࡿ18ࡢ᪉ἲ㸸⦅ⴭࠊ㟷ฟ∧ࠊᮾி㸬
2008.
୰⏣ ༤㸬㑇ఏᏊ་Ꮫ MOOK11㸸ᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࡢ⏕≀Ꮫⓗᶵ⬟,
pp148-154, ࣓ࢹ࢝ࣝࢻ࢘ࠊᮾி, 2008㸬
ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨ ࠶࡞ࡓࡢࣃࣥࢹ࣑ࢵࢡᑐ⟇ࡣ㛫㐪ࡗ࡚࠸
ࡿ㸽㸟㸸┘ಟࠊ㏆௦ᾘ㜵♫ࠊᮾி㸬2008.
⥲ㄝཬࡧゎㄝ
ⴱཎ 㝯ࠊὠୗⱥ᫂. ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ RNA ࣏࣓࣮ࣜࣛࢮࡢࢻ࣓ࣥ
ࡢ❧యᵓ㐀㸦ࡳࢀࡧࡹ࠺㸧㸬⏕Ꮫ, 84, 780-785, 2012.
Nakada, H. Ikuo Yamashina: a pioneer who established the basis of current
glycobiology. Journal of Biochemistry, 151, 461-468, 2012.
ᵳබ୍ࠊ㧗᱓ᘯᶞࠊ⸭⏣ῄணࠊᒣᒸᩄஅ㸬㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ἣ㸬⮫ᗋ
◊✲, 89, 1676-1682, 2012.
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊୖ⍞ỤࠊᖖᅧⰋኴࠊ⸭⏣ῄண㸬㉥⾑⌫จ㞟⣲ኚ␗ࢆຍ
37
−72−
࠼ࡓH5N1ளᆺ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡀங㢮ࡢឤᰁᛶࢆ⋓ᚓࡋࡓ⏬
ᮇⓗ࡞Ἑᒸ⩏⿱ᩍᤵࡽࡢㄽᩥࡘ࠸࡚࣮ࢹ࣮ࣗࣝࣘࢫࡀᠱᛕࡉࢀࡓ࣮㸬
ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 11, 31-39, 2012.
ᡞ⏣᐀㇏ࠊᮧ⏣⮧ࠊ➲㔝᪸ኴࠊ୰⏣ ༤㸬ேᕤࢢࣜࢥ࣏࣐࣮ࣜࡼࡿ⒴㌿⛣
ᢚไ࠾ࡼࡧᢠ⅖స⏝㸬ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ㸪No. 10, 15-23,
2011.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨⓎ⏕࣭ឤᰁᣑࡢྍ⬟ᛶ㸬࣌ࢫࢺࢥࣥࢺ࣮ࣟࣝ, No.
158, 4-9, 2011.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡢᇶ♏ᅜෆእࡢⓎ⏕≧ἣࡘ࠸࡚㸬᪥ᮏᐙ⚺Ꮫ
ㄅ48㸦⛅Ꮨྕ㸧, 1-4, 2011
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫࡢ⏕ែ㸬ᮾᾏ␆⏘Ꮫሗ㸪22㸪2-6, 2011㸬
ᵳබ୍㸬Ⓨ⏕ࡀṆࡲࡽ࡞࠸㫽ࣥࣇ࢚ࣝࣥࢨ㸬SEEDer, No. 5, 78-82, 2011.
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄண㸬2010ᖺᬌ⛅ࡽᅜෆ࡛ከ
Ⓨࡋࡓ㫽ࣥࣇ࢚ࣝࣥࢨ㸬ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 10, 45-61,
2011.
ᵳබ୍㸬ㅮᗙ ὀ┠ࡉࢀࡿឤᰁไᚚᑐ⟇㸵 㫽ࣥࣇ࢚ࣝࣥࢨ㸬㜵⳦㜵
㰄, 39㸪375-387, 2011㸬
ᵳබ୍㸬ㅮᗙ ࡃࡽࡋᚤ⏕≀㸳 ࣐ࢫࢡ㸬㜵⳦㜵㰄㸪39(3), 175-183, 2011.
ᵳබ୍㸬᪥ᮏྛᆅ࡛Ⓨ⏕ࡋ࡚࠸ࡿ㧗ཎᛶ㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ἣ㸬㭜ࡢ◊✲,
86(3)㸪15̽20, 2011㸬
ᵳබ୍㸬㧗ཎᛶ㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ἣࡇࢀࡽࡢഛ࠼㸬㎰ᴗ⤒῭㸪77(2),
79-88, 2011㸬
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄண㸬≉㞟㸭᪂ᆺࣥࣇ࢚ࣝࣥ
ࢨ AH1N1ࡢὶ⾜ࢆࡾ㏉ࡗ࡚㸬ࢺࣜࣥࣇ࢚ࣝࣥࢨࡢὶ⾜≧ἣ㸬⮫ᗋ◊
✲㸪87, 1718-1723, 2010.
ᵳබ୍㸬≉㞟ࣥࣇ࢚ࣝࣥࢨ㸬ࣈࢱ࣭ࢺࣜࣥࣇ࢚ࣝࣥࢨࡢ⌧≧㸬ᑠඣෆ⛉㸪
42㸪2010.
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊୖ⍞Ụࠊ⸭⏣ῄணࠊ୰ᮧಖ⣖ࠊᯇୗ⨾⣖ࠊᒣ
ྡⱥ᫂㸬ࣥࣇ࢚ࣝࣥࢨᑐ⟇ࠊ≉㧗ᶵ⬟ຍ࣐ࢫࢡࡢ᭷⏝ᛶ. ி㒔⏘ᴗ
38
−73−
Ꮫඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 9, 103-117, 2010.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ᪂ᆺ࢘ࣝࢫࡢୡ⏺ⓗὶ⾜㸦ࣃࣥࢹ࣑ࢵࢡ㸧
㸬㜵⳦
㜵㰄㸪38, 297-307, 2010.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ̿ࢪ࠾ࡅࡿH5N1ளᆺ࢘ࣝࢫࡢ⏕ែ
—㸬⮫ᗋᚤ⏕≀㸪37(2), 99-104, 2010.
ᵳබ୍ ㇜ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ㉳ᅉࡍࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢⓎ⏕ὶ
⾜㸬㭜ࡢ◊✲, 84(7), 36-39, 2009.
ᵳබ୍㸬ឡ▱┴࡛Ⓨ⏕ࡋࡓ㫽ࣥࣇ࢚ࣝࣥࢨ㸬㭜ࡢ◊✲, 84(5), 20-23, 2009.
ᵳබ୍㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨࡢṇయ—࢘ࣝࢫฟ⌧ࡢ⤒⦋ࡑࡢ≉ᛶ—㸬Ꮫ㸪
64(10), 12-17, 2009.
ᵳබ୍㸬ࢪࡢ㫽ࣥࣇ࢚ࣝࣥࢨ—Ⓨ⏕≧ἣ㸬㭜◊✲ሗ㸪45㸦ቑหྕ㸧
㸪
17Ѹ21, 2009㸬
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊ୰ᮧಖ⣖ࠊୖ⍞Ụ㸬2009ᖺฟ⌧
ࡋࡓ࠸ࢃࡺࡿ᪂ᆺࣥࣇ࢚ࣝࣥࢨ. ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ,
No. 8, 75-82, 2009.
ᵳබ୍㸬ᕳ㢌ゝ 2008ᖺ4᭶㡑ᅜ࡛Ⓨ⏕ࡋࡓ㫽ࣥࣇ࢚ࣝࣥࢨ㸬ࣥࣇ࢚ࣝࣥ
ࢨ, 10(1), 9-10, 2009.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸲㸬᪂ᆺࣥࣇ࢚ࣝࣥ
ࢨᑐ⟇㸬㏆௦ᾘ㜵, No. 577, 92-94, 2009.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸱㸬㫽ࣥࣇ࢚ࣝࣥࢨ
ࡘ࠸࡚㸬㏆௦ᾘ㜵, No. 576, 94-95, 2009.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 㸰㸬㫽ࣥࣇ࢚ࣝࣥࢨ
ࡘ࠸࡚㸬㏆௦ᾘ㜵, No. 575, 90-91, 2008.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡽ᪂ᆺࣥࣇ࢚ࣝࣥࢨ 1㸬㫽ࣥࣇ࢚ࣝࣥࢨ
ࡘ࠸࡚㸬㏆௦ᾘ㜵, No. 574, 69-71, 2008.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨ̿ࡇࡢഛ࠼࡚㸬㭜ࡢ◊✲, 83(11), 22-25, 2008.
ᵳබ୍㸬㸲᭶㉳ࡁࡓᾏ㐨࣭ᮾᆅᇦࡢ㫽ࣥࣇ࢚ࣝࣥࢨ㸬㭜ࡢ◊✲, 83(7),
18-21, 2008.
39
−74−
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡢ⌧ẁ㝵—㫽ࡽࣄࢺࠊࣄࢺࡽࣄࢺࡢఏࡣ
ࡇࡲ࡛㐍ࢇ࡛࠸ࡿ㸬᭶หಖᅋ㐃㸪No. 982, 25-30, 2008.
ᵳබ୍ࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ୰㞞ᬗ ᭱ࡶ༴㝤࡞እ᮶ᛶࡢ㫽⏤᮶ே⋇ඹ㏻
ឤᰁ—㫽ࣥࣇ࢚ࣝࣥࢨ̿. ி㒔⏘ᴗᏛඛ➃⛉Ꮫᢏ⾡◊✲ᡤሗ, No. 7,
161-176, 2008.
ᵳබ୍㸬
ே⋇ඹ㏻ឤᰁࡋ࡚ࡢ㫽ࣥࣇ࢚ࣝࣥࢨ㸬
㫽ྲྀ་Ꮫ㞧ㄅ, 34, 3-6, 2008.
ᵳබ୍㸬㫽ࣥࣇ࢚ࣝࣥࢨࡣ㸬ᡂே⏕ά⩦័, 38, 1244-1250 , 2008.
M.Toda and H.Nakada; Immunosuppressive effect of carcinoma-produced mucins on B
cell function. pp 226-238. 2010, FCAA.
୰⏣ ༤㸬࣒ࢳࣥࢆࡋࡓ⭘⒆⣽⬊ࡢቑṪ࣭㐍ᒎ㸬⺮ⓑ㉁᰾㓟㓝⣲, 53,
1604-1610, 2008.
ᏛⓎ⾲
1. Koichi Otsuki. Outbreaks of avian influenza in Japan –An outbreak of H5N1 HPAI in
Kyoto prefecture and management done by local government. BIT’s 1st World
Congress of Virus and Infections-2010. Theme: Voice of Virologits, Busan, South
Korea, 31st July-3rd August 2010.
2. Hiroki Takakuwa, Toshihiro Ito, Toshiyuki Murase, Tetsu Yamashiro, Etsuro Ono and
Koichi Otsuki. Molecular epidemiology of avian influenza in northern Vietnam.
Workshop on the Influenza Research of J-GRID: The Inaugural Meeting of the
Influenza Consortium, Tokyo, 16th July 2010.
3. Hiroki Takakuwa, Tetsu Yamashiro, Mai Quynh Le, Lien Song Phuong,
RyotaTsunekuni, Tatsufumi Usui, Hiroichi Ozaki, Hiroshi Ito, Tsuyoshi Yamaguchi,
Toshihiro Ito, Koichi Otsuki, Toshiyuki Murase, and Etsuro Ono. Molecular
epidemiology of avian influenza viruses circulating among healthy poultry bred in
farms in northern Vietnam. 4th Annual Meeting EPIZONE, St Malo, France, 7th – 10th
June 2010.
4. Hiroki Takakuwa, Tetsu Yamashiro, Le Quynh Mai, Phuong Son Lien, Etsuro Ono,
Ryota Tsunekuni, Tatsufumi Usui, Hiroichi Ozaki, Hiroshi Itoh, Takeshi Yamaguchi,
Toshihiro Ito, Koichi Otsuki, and Toshiyuki Murase, Infection of H5N1 avian
influenza viruses in healthy ducks on farms in northern Vietnam. International Joint
Forum on Infectious Diseases. Bangkok, Thailand, 16th-17th September 2009.
5. Koichi Otsuki, Etsuro Ono, Hiroki Takakuwa, Toshiyuki Murase, Toshihiro Ito, Hiroshi
Itoh, Le Ouynh Mai, Phuong Son Lien, Kouichi Morita, Tetsu Yamashiro.
Epizootiology of Avian Influenza. The International Symposium on Environmental
Change, Pathogens, and Human Linkages, Research Institute for Humanity and Nature
40
−75−
in Kyoto, 11th-14th June 2008.
6. Koichi Otsuki, Etsuro Ono, Hiroki Takakuwa, Toshiyuki Murase, Toshihiro Ito, Le
Ouynh Mai, Phuong Son Lien, Kouichi Morita, Tetsu Yamashiro. Surveillance of
Avian Influenza Virus in Vietnam. The Asian Research Forum on Emerging and
Reemerging Infections, 2008, Osaka 28th-29th January 2008.
7. H.Nakada, Y.Mori, S.Tanida K.Akita A.Ishida M.Toda M.Inoue. Interaction of
MUC1 with Galectin-3 enhances the proliferation of epithelial tumor cells. 26
International Carbohydrate Symposium. Madrid,Spain [2012.7.22-27]
8. ୰⏣ ༤ࠊඵ௦ṇࠊ⃝⏣㕲ࠊᖹᕝᘯ⪷㸬࢞ࣞࢡࢳࣥ-3 ࡢ MUC1 ࡢ⤖ྜ
క࠺⒴⣽⬊ቑṪಁ㐍స⏝㸬➨ 21 ᅇ᪥ᮏࡀࢇ㌿⛣Ꮫࠊᗈᓥ [2012.7.12-13]
9. ⛅⏣ ⸅ࠊụཎ ㆡࠊ୰す㏿ኵࠊᡂᯇ ஂࠊ୰⏣ ༤. MUC16ୖࡢsTnᢠཎࡢⓎ⌧
ᇶ࡙ࡃᏊᐑෆ⭷༸ᕢ⒴ࡢ㆑ู. NEDO⢾㙐ࣉࣟࢪ࢙ࢡࢺᡂᯝሗ࿌ࠊᮾ
ி [2011.11.16-17]
10. G.P. Subedi, T. Satoh, S. Hanashima, A. Ikeda, H. Nakada, R. Sato, M.Mizuno, N.
Yuasa, Y. Fujita-Yamaguchi, Y. Amaguchi. NMR analysis of an anti-carbohydrate
antibody single-chain Fv fragment toward elucidation of the multivalent recognition
mechanism. The International Symposium on Nuclear Magnetic Resonance.
Yokohama,Japan [2011.11.15-18]
11. ୰⏣ ༤. ࣒ࢳࣥࣇ࣑࣮ࣜ㸹⭘⒆࣐࣮࣮࢝ࡢⓎ⌧ࠊᵓ㐀࠾ࡼࡧ⭘⒆ᝏᛶ
ࡢ㛵㐃ᛶ. ➨6ᅇ⢾㙐⏘ᴗᢏ⾡ࣇ࢛࣮࣒ࣛࠊᶓ [2011.10.5]
12. ᯇᮏᗣஅࠊ❶ 㟷ࠊᮧ⣖ࠊ⛅⏣ ⸅ࠊ୰⏣ ༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥ
ᚭஓࠊྂᕝᆂᏊࠊᾆ㔝 ࠊྂᕝ㗰୍. pp-GalNAc-T13 ࡣ trimeric Tn ᢠཎࢆྜ
ᡂࡍࡿࡇࡼࡾ⒴㌿⛣ࢆஹ㐍ࡉࡏࡿ㸸ᶆⓗࢱࣥࣃࢡ㉁ࡢྠᐃ. ➨ 70 ᅇ᪥ᮏ
⒴ᏛᏛ⾡⥲ࠊྡྂᒇ [2011.10.3-5]
13. ⛅⏣ ⸅ࠊụཎ ㆡࠊୖ⍞Ụࠊ୰す㏿ኵࠊᡂᯇ ஂࠊ୰⏣ ༤. Ꮚᐑෆ⭷࠾ࡼ
ࡧ༸ᕢ⒴ᝈ⪅࠾ࡅࡿ CA125 ࢥࢱࣥࣃࢡ㉁ୖࡢࢩࣜࣝ Tn ᢠཎࣞ࣋ࣝࡢ
⮫ᗋⓗホ౯. ➨ 84 ᅇ᪥ᮏ⏕Ꮫࠊி㒔 [2011.9.21-24]
14. ➲㔝᪸ኴࠊᡞ⏣᐀㇏ࠊᒾྖࠊ☄ịὈᕷࠊᮧ⏣⮧ࠊ୰⏣ ༤. ேᕤࢢࣛ
ࢥ࣏࣐࣮ࣜࡼࡿ⒴㌿⛣ᢚไ࠾ࡼࡧᢠ⅖స⏝. ➨ 84 ᅇ᪥ᮏ⏕Ꮫࠊ
ி㒔 [2011.9.21-24]
15. ᯇᮏᗣஅࠊ❶ 㟷ࠊᮧ⣖ࠊ⛅⏣ ⸅ࠊ୰⏣ ༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥ
ᚭஓࠊྂᕝᆂᏊࠊᾆ㔝 ࠊྂᕝ㗰୍. pp-GalNAc-T13 ࡼࡿ⒴㌿⛣ࡢศᏊ࣓
࢝ࢽࢬ࣒. ➨ 84 ᅇ᪥ᮏ⏕Ꮫࠊி㒔 [2011.9.21-24]
16. ᳃ ຬఃࠊ⛅⏣ ⸅ࠊ㇂⏣࿘ᖹࠊ▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣ ༤. ࣄ
ࢺ⭠⒴⏤᮶⣽⬊࠾ࡅࡿ MUC1 Galectin-3 ࡢ┦స⏝ࡼࡿቑṪಁ㐍ຠ
ᯝ. ➨ 84 ᅇ᪥ᮏ⏕Ꮫࠊி㒔 [2011.9.21-24]
17. ㇂⏣࿘ᖹࠊ⛅⏣ ⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣ ༤. MUC1 Galectin-3 ࡢ⤖
ྜࡑࡢ⏕≀Ꮫⓗព⩏. ➨ 84 ᅇ᪥ᮏ⏕Ꮫࠊி㒔 [2011.9.21-24]
18. H. Nakada, S. Tanida, K. Akita, M. Toda, M. Inoue. MUC1 mediated signaling
through ligation with Siglec-9. The 21st International Symposium on Glycoconjugates.
Vienna, Austria [2011.8.21-26]
41
−76−
19. K. Akita, S. Yoshida, Y. Ikehara, S. Shirakawa, M. Toda, M. Inoue, J.Kitawaki, H.
Nakanishi, H. Narimatsu, H. Nakada. Clinical evaluation of sialyl-Tn antigen level on
CA125 core protein inpatients with endometriosis and ovarian cancer. The 21st
International Symposium on lycoconjugates. Vienna,Austria [2011.8.21-26]
20. ᯇᮏᗣஅࠊ❶ 㟷ࠊᮧ⣖ࠊ⛅⏣ ⸅ࠊ୰⏣ ༤ࠊᚨ⏣௦ࠊᅵ⏣᫂Ꮚࠊᒸᓥ
ᚭஓࠊྂᕝᆂᏊࠊᾆ㔝 ࠊྂᕝ㗰୍. pp-GalNAc-T13 ࡣtrimeric Tn ᢠཎࢆᙧ
ᡂࡋ⒴㌿⛣ࢆஹ㐍ࡉࡏࡿᶆⓗࢱࣥࣃࢡ㉁ࡢྠᐃ. ➨30 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊ
㛗ᒸ [2011.7.11-13]
21. ୰⏣ ༤ࠊ㇂⏣࿘ᖹࠊ⛅⏣ ⸅ࠊᡞ⏣᐀㇏㸬ෆᅾᛶࣞࢡࢳࣥࡢ⤖ྜక࠺MUC1
ࢆࡋࡓࢩࢢࢼࣝఏ㐩㸬➨30 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊ㛗ᒸ [2011.7.11-13]
22. ୖ⍞Ụࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊఀ⸨ኖၨࠊᵳබ୍ࠊ୰⏣༤㸬
ࢽ࣡ࢺࣜẼ㐨ୖࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⤖ྜ⺮ⓑ㉁ࡢ᳨⣴㸬
➨33ᅇ᪥ᮏศ
Ꮚ⏕≀Ꮫᖺ࣭➨83ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
23. ▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣ ⸅ࠊୖ⍞Ụࠊ୰⏣ ༤. ࢩࢢࣞࢵࢡ㸱ࡼࡿ
Toll-like receptor-㸲ࢩࢢࢼࣝఏ㐩ࡢᢚไ. ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83
ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
24. ᡞ⏣᐀㇏ࠊᒣୗ⥅ྐࠊΏ㑓ᫀᙪࠊ▼⏣᭷ᕼᏊࠊ⛅⏣ ⸅ࠊୖ⍞Ụࠊᮧ⏣
⮧ࠊ☄ịὈᕷࠊ୰⏣ ༤㸬Immunosuppressive effect of mucin on splenic marginal
zone B cells in tumor-bearing state. ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ
⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
25. ㇂⏣ ࿘ᖹࠊ⛅⏣ ⸅ࠊᡞ⏣ ᐀㇏ࠊୖ ⍞Ụࠊ୰⏣ ༤. Siglec-9 ࡢ⤖ྜ
క࠺ MUC1 ࢆࡋࡓሗఏ㐩. ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ
⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
26. ቑ⏣ ┤ஓࠊࢨ࣒ࣜ ࣀ࣮࣐ࣝࢨࠊỌ ♸ᐅࠊ▮ᓥ ⏤⣖Ꮚࠊ୰⏣ ༤ࠊᒣ
ཱྀ㸦⸨⏣㸧㝧Ꮚ. ᢠ Tn ᢠయ MLS128 ࡢࣄࢺ⤖⭠ࡀࢇ⣽⬊ HT29 ᑐࡍࡿቑ
Ṫᢚไస⏝. ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠ
ࠊ⚄ᡞ [2010.12.7-10]
27. ᒾ ྖࠊ ᒸ ಟᖹࠊ ᡞ⏣ ᐀㇏ࠊ ☄ị Ὀᕷࠊᮧ⏣ ⮧ࠊ ୰⏣ ༤. ◲
㓟⢾ྵ᭷ேᕤ࣒ࢳࣥ P-ࢭࣞࢡࢳࣥࡢ┦స⏝ࡢゎᯒ. ➨ 33 ᅇ᪥ᮏศᏊ
⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ⚄ᡞ [2010.12.7-10]
28. G.P. Subedi, T.Satoh, S. Hanashima, A.Ikeda, H.Nakada, R. Sato, M. Mizuno,
N.Yuasa, Y. Fujita-Yamaguchi, and Y.Yamaguchi. Establishment of overproduction
procedure for anti-Tn antigen MLS128 single-chain Fv fragment toward the structural
studies. ➨ 33 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 83 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ
⚄ᡞ [2010.12.7-10]
29. ୰⏣ ༤㸬ච⣽⬊ࡢ࣒ࢳࣥ⤖ྜศᏊࢆ⫼ᬒࡍࡿචไᚚࡢ㛤Ⓨ. ㏆␥ࣂ
࢜ࣥࢲࢫࢺ࣮ࣜ⯆㆟ࠊ㜰 [2010.12]
30. ୖ⍞Ụࠊ㧘᱓ᘯᶞࠊᖖᅧⰋኴࠊ⸭⏣ῄணࠊఀ⸨ኖၨࠊᵳබ୍ࠊ୰⏣༤㸬
ࢽ࣡ࢺࣜẼ㐨ୖࡢ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫ⤖ྜ⺮ⓑ㉁ࡢ᳨⣴㸬➨ 58 ᅇ࢘
ࣝࢫᏛᏛ⾡⥲ࠊᚨᓥ[2010.11.7-9]
31. ୰⏣༤ࠊୖ⍞Ụ㸬ࢩࢢࣞࢵࢡ 9 ࡢ┦స⏝ࡼࡿ MUC1 ࢆࡋࡓࢩࢢࢼ
42
−77−
ࣝఏ㐩㸬MUC1 mediated signaling through interaction with Siglec-9. ➨ 69 ᅇ᪥ᮏ
⒴ᏛᏛ⾡⥲ࠊp.81ࠊ2010.9.22ࠊ㜰 [2010.9.22-24]
32. T. Murata, T. Hattori, Y. Honda, M. Toda, E. Y. Park, T. Usui, and H.Nakada.
Chemoenzymatic synthesis of artificial mucins carrying sialylated O-linked glycans
with a polylactosamine extension and interactions with CD22/siglec-2. The 25th
International Carbohydrate Symposium. Chiba,Japan [2010.8.1-6]
33. Hiroshi Nakada. Signal transduction through MUC1-Siglec 9 interaction. 7th
International Symposium on Glycosyltransferases, GlycoT 2010, p.54-55, 2010.8.1
Tokyo, Japan [2010.7.31-8.1]
34. ྜྷ⏣࿘ᖹࠊ⛅⏣⸅ࠊᑠᇼ☻ዉ⨾ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬࢞ࣞࢡࢳࣥ
-3 ࡼࡿ MUC-1 ࢆࡋࡓ࢞ࣥ⣽⬊ቑṪಁ㐍స⏝㸬Galectin-3 promotes cell
proliferation of MUC1-expressing cancer cells. ➨82 ᅇ᪥ᮏ⏕Ꮫࠊ
p336ࠊ
2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
35. ㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬Siglec-9 ࡢ MUC1 ࡢ⤖
ྜక࠺ሗఏ㐩ࢆ⣽⬊ᐦᗘࡼࡿ┦㐪㸬MUC1 mediated signaling through
ligation with Siglec-9 and its alteration due to different cell density. ➨ 82 ᅇ᪥ᮏ⏕
Ꮫࠊp336ࠊ2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
36. ᡞ⏣᐀㇏ࠊᒣୗ⥅ྐࠊΏ㑓ᫀᙪࠊᮌ⫕ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊᮧ⏣⮧ࠊ☄
ịὈᕷࠊ୰⏣༤㸬Immunosuppressive effect of mucin on splenic marginal zone B cells
in tumor-bearing state. ➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp336ࠊ2009.10.24ࠊ⚄ᡞ
[2009.10.21-24]
37. ▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 3 ࠾ࡼࡧ 9
ࡼࡿ Toll-like receptor-4 ࢩࢢࢼࣝఏ㐩ࡢᢚไ㸬Regulation of Toll-like receptor-4
mediated signaling by Siglec-3 and 9. ➨ 82 ᅇ᪥ᮏ⏕Ꮫࠊp344ࠊ
2009.10.24ࠊ⚄ᡞ [2009.10.21-24]
38. ୰⏣༤ࠊୖ⍞Ụ㸬⭘⒆⏘⏕࣒ࢳࣥࡢࢩࢢࣞࢵࢡ 2 ࡢ⤖ྜࢆࡋࡓ⭁⮚࣐
࣮ࢪࢼࣝࢰ࣮ࣥ B ⣽⬊ࡢᦆയ㸬Impairment of splenic marginal zone B cells by
ligation of tumor-produced mucins to Siglec 2. ➨ 68 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊ
p.278ࠊ2009.10.2ࠊᶓ [2009.10.1-3]
39. ㇂⏣࿘ᖹࠊ⛅⏣⸅ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬ࢩࢢࣞࢵࢡ 9 ࡢ⤖ྜక
࠺ MUC1 ࢆࡋࡓሗఏ㐩㸬
Signal transduction through MUC1 with the binding of
Siglec-9. ➨ 29 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.160ࠊ2009.9.11㸪㧗ᒣ [2009.9.9-11]
40. ▼⏣᭷ᕼᏊࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊ
ୖ⍞Ụࠊ୰⏣༤㸬
ࢩࢢࣞࢵࢡ 3 ࡼࡿ Toll-like
receptor-4 ࢩࢢࢼࣝఏ㐩ࡢᢚไ㸬Siglec-3 regulates signal transduction mediated by
Toll-like receptor-4. ➨ 29 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.165ࠊ2009.9.11㸪㧗ᒣ
[2009.9.9-11]
41. ᮌ⫕ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ⛅⏣⸅ࠊᮧ⏣⮧ࠊ☄ịὈᕷࠊ୰⏣༤㸬Siglec-E
ࡢ◲㓟⢾㙐ࡢ⤖ྜ㸬Binding of Siglec-E to sulfated oligosaccharide. ➨ 29 ᅇ
᪥ᮏ⢾㉁Ꮫᖺࠊp.168ࠊ2009.9.11ࠊ㧗ᒣ [2009.9.9-11]
42. ୰⏣༤㸬⒴ᚤᑠ⎔ቃ࠾ࡅࡿ࣒ࢳࣥࢆࡋࡓචᢚไ⭘⒆ቑṪ㸬➨ 18 ᅇ᪥
ᮏࡀࢇ㌿⛣ᏛᏛ⾡㞟ࠊp.14ࠊ2009.7.23ࠊ᪫ᕝ [2009.7.23-24]ㅮ₇
43
−78−
43. Hiroshi Nakada. Mucin-mediated immune regulation and tumor progression.
Clinical and Translational Research on Cancer: Blycomics Applications, p.62-63,
2009.3.26. Mie, Japan [2009.3.24-27]
44. ㇂⏣࿘ᖹࠊ⸨ᮏ⚈ᙲࠊኴ⏣㯞Ꮚࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊ୰⏣༤㸬
ࢩࢢࣞࢵࢡ 9 ࡢ⤖ྜక࠺ MUC1 ࢆࡋࡓሗఏ㐩㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀Ꮫ
ᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊp161ࠊ2008.12.9ࠊ⚄ᡞ
[2008.12.9-12]
45. ▼⏣ளᕼᏊࠊኴ⏣㯞Ꮚࠊᮌ⫕ࠊᡞ⏣᐀㇏ࠊ⛅⏣⸅ࠊୖ⍞Ụࠊᮧ⏣⮧ࠊ
☄ịὈᕷࠊ୰⏣༤㸬༢⌫㸭ᶞ≧⣽⬊ࡢࢩࢢࣞࢵࢡ 3 ཬࡧ 9 ࡢ࣒ࢳࣥࡢ⤖ྜ
⏕≀Ꮫⓗព⩏㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠ
ࠊp161ࠊ2008.12.9ࠊ⚄ᡞ [2008.12.9-12]
46. ᑠᒣⰾỤࠊྜྷᐩὈኸࠊᲷᒃ⪷୍ࠊᡞ⏣᐀㇏ࠊ୰⏣༤ࠊᒸᒣᐿࠊᑠᰩె௦Ꮚ㸬
࣊ࣃࣛࣥ◲㓟⬺ 6 ◲㓟㓝⣲ࠊSulfsࠊࡢ⒴㌿⛣ᢚไస⏝㸬➨ 31 ᅇ᪥ᮏศᏊ⏕≀
Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊp169ࠊ2008.12.9ࠊ⚄ᡞ
[2008.12.9-12]
47. Kazuhiro Tsukamoto, Ayano Matsumoto-Takasaki, Noriyuki Yuasa, Keiko Sakai,
Yukiko Yamaji, Hiroshi Nakada, Hideki Asanuma, Yoko Fujita-Yamaguchi.
Construction and characterization of single-chain variable fragments (scFvs) from
hybridoma producing anti-tn antigen monoclonal antibody, MLS128. ➨ 31 ᅇ᪥ᮏ
ศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊp172ࠊ2008.12.9ࠊ⚄
ᡞ [2008.12.9-12]
48. ⛅⏣⸅ࠊ℈ཱྀ┿ⱥࠊ୰ᔱ❶㞝ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊᕝே㇏ࠊ୰⏣༤㸬ྍ⁐
ᆺࢫ࢝࣋ࣥࢪ࣮ࣕཷᐜయࢆ⏝࠸ࡓ࣐࢘ࢫ㛵⠇⅖ᑐࡍࡿᢠ⅖ຠᯝ㸬➨ 31 ᅇ
᪥ᮏศᏊ⏕≀Ꮫᖺ࣭➨ 81 ᅇ᪥ᮏ⏕Ꮫྜྠࠊ
p161ࠊ
2008.12.10ࠊ
⚄ᡞ [2008.12.9-12]
49. ୰⏣༤㸬࣒ࢳࣥୖⓎ⌧ࡉࢀࡿ⒴㛵㐃⢾㙐ᢠཎ㸬Tumor-associated carbohydrate
antigens expressed on mucins. ➨ 67 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲ࠊp.478ࠊ2008.10.30ࠊ
ྡྂᒇ [2008.10.28-30]
50. ୖ⍞Ụࠊ୰⏣༤㸬ୖ⓶ᛶ⒴ࡢᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࡢ⏕≀Ꮫⓗព⩏㸬
Biological significance of mucins in epithelial tumor-bearing state. ➨ 67 ᅇ᪥ᮏ⒴
ᏛᏛ⾡⥲ࠊp.265ࠊ2008.10.29ࠊྡྂᒇ [2008.10.28-30]
51. ሯᮏᾈࠊ㓇ᜨᏊࠊᮌᓮᏳ⣖Ꮚࠊὸᚨ⾜ࠊ㧗ᓮ㸦ᯇᮏ㸧⥤ࠊὸ⚽ᶞࠊ
బ⸨⋹ᏊࠊᕝୖᏹᏊࠊỈ㔝┿┒ࠊ㧗ᰗ῟ࠊ୰⏣༤ࠊᒣཱྀ㸦⸨⏣㸧㝧Ꮚ㸬Tn ᢠ
ཎ≉␗ⓗ༢ࢡ࣮ࣟࣥᢠయ MLS128 83D4 ⏤᮶༢㙐ᢠయࡢㄪ〇≉␗ᛶゎᯒ㸬
➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺࠊp.xxvࠊ2008.8.19ࠊࡘࡃࡤ [2008.8.18-20]
52. ⛅⏣⸅ࠊ୰ᔱ❶㞝ࠊᡞ⏣᐀㇏ࠊୖ⍞Ụࠊ୰⏣༤㸬⓶യ⒵࠾ࡅࡿ࣐
ࢡࣟࣇ࣮ࢪࢡࣛࢫ A ࢫ࢝࣋ࣥࢪ࣮ࣕཷᐜయࡢ⏕≀Ꮫⓗព⩏㸬➨ 28 ᅇ᪥ᮏ⢾
㉁Ꮫᖺࠊp.xxࠊ2008.8.20ࠊࡘࡃࡤ [2008.8.18-20]
53. ᮧ⏣⮧ࠊᡞ⏣᐀㇏ࠊ☄ịὈᕷࠊ୰⏣༤㸬◲㓟⢾ྵ᭷ேᕤ࣒ࢳ࣐ࣥࢡࣟ
ࣇ࣮ࢪࢫ࢝࣋ࣥࢪࣕࣜࢭࣉࢱ࣮ࡢ┦స⏝ゎᯒ㸬➨ 28 ᅇ᪥ᮏ⢾㉁Ꮫᖺ
ࠊp.xxࠊ2008.8.19ࠊࡘࡃࡤ [2008.8.18-20]
44
−79−
54. ୰⏣༤ࠊᡞ⏣᐀㇏ࠊ⸨ᮏ⚈ᙲࠊ㇂⏣࿘ᖹࠊ▼⏣᭷ᕼᏊࠊኴ⏣㯞Ꮚࠊ⛅⏣⸅ࠊ
ୖ⍞Ụ㸬ᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࢆࡋࡓᵝࠎ࡞⏕≀Ꮫⓗᶵ⬟㸬➨ 28 ᅇ᪥
ᮏ⢾㉁Ꮫᖺࠊp.xiࠊ2008.8.18ࠊࡘࡃࡤ [2008.8-18-20]
55. ୰⏣༤㸬ᢸ⒴≧ែ࠾ࡅࡿ࣒ࢳࣥࡢ⏕≀Ꮫⓗᶵ⬟㸬ᖹᡂ 20 ᖺᗘᮾᾏᏛ⏕⌮
Ꮫ◊✲ᡤ◊✲࣭⢾㙐ᶵ⬟◊✲ࠊp.Xࠊ2008.5.22ࠊᒸᓮ [2008.5.22-23]
56. ⣽㔝㞝୕㸬ධၥ㢟㐍⾜Ἴゎ㸬᪥ᮏᩘ⌮Ꮫࠊி㒔ࠊᖹᡂ 20 ᖺ 8 ᭶㸬
57. ᕝᮏဴ㑻㸬ឤᰁἲ࠾ࡅࡿேᶒࡢ㓄៖㸬ᖹᡂ㸰㸲ᖺᗘ᪥ᮏ♫་Ꮫ⥲㸬
2012.7.16ࠊ㜰࣭㧗ᵳᕷ
58. S.Fukui and M. Kawahara. Rat CD24 is one of major poly-N- acetyllactosamine
-carrying glycoproteins in PC12 cells and rat bone marrow, but not in PC12D cells and
rat brain. ➨ 20 ᅇᅜ㝿」ྜ⢾㉁ࢩ࣏ࣥࢪ࣒࢘ ࢧࣥࣇࣥࠊࣉ࢚ࣝࢺࣜࢥ ᖹ
ᡂ 21 ᖺ 11 ᭶㸬
59. ྜྷ⏣ளభ⨾㸪℩ᑿ⨾㕥㸬VEGF-A ࡢ Neuropilin ࢆࡋࡓ⒴⣽⬊ࡢቑṪಁ㐍. ➨
14 ᅇ᪥ᮏࡀࢇศᏊᶆⓗ⒪ᏛᏛ⾡㞟㸬ᮾி㸬ᖹᡂ 22 ᖺ㸵᭶㸬
60. ྜྷ⏣ளభ⨾㸪ᑎ⏣ᇶ๛㸪ΎỈ⏨㸪℩ᑿ⨾㕥㸬⾑⟶ෆ⓶⣽⬊ቑṪᅉᏊ(VEGF-A)
ࡣࠊ⒴⣽⬊⮬㌟ࡢቑṪ࣭ࢥࣟࢽ࣮ᙧᡂࢆಁ㐍ࡍࡿ㸬➨ 57 ᅇ᪥ᮏ⏕Ꮫ㏆␥
ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
61. ᔱᮁ㸪ᒸᮏἋ▮㤶㸪ᑎ⏣ᇶ๛㸪᳃ᕝຬ㈗㸪ΎỈ⏨㸪బ⸨┤Ꮚ㸪⥴᪉㸪
℩ᑿ⨾㕥㸬࣐࢝ࣝࣥೃ⩌ཎᅉ㑇ఏᏊ⏘≀ Anosmin-1 ࡣ FGFR1 άᛶࡼࡿ
ᡂ㛗㗹ᙧᡂࢆಁ㐍ࡍࡿ㸬➨ 57 ᅇ᪥ᮏ⏕Ꮫ㏆␥ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22
ᖺ 5 ᭶㸬
62. ᒸᮏἋ▮㤶㸪᳃ᕝຬ㈗㸪ྜྷᘅ⨾㔛㸪ᔱᮁ㸪ᑎ⏣ᇶ๛㸪ΎỈ⏨㸪బ⸨┤Ꮚ㸪
⥴᪉㸪℩ᑿ⨾㕥㸬FGFR1 acid box 㡿ᇦࡣ⚄⤒✺㉳ఙ㛗㔜せ࡞ᙺࢆᯝࡓࡍ㸬
➨ 57 ᅇ᪥ᮏ⏕Ꮫ㏆␥ᨭ㒊㸬ዉⰋ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
63. ᑎ⏣ᇶ๛㸪ᒸᮏἋ▮㤶㸪すຊ㸪ୖ㔝ಙὒ㸪ΎỈ⏨㸪㔠㝣⾜㸪℩ᑿ⨾㕥㸬
ᝏᛶᡥᖹୖ⓶⒴⣽⬊࠾ࡅࡿ⥺⥔ⱆ⣽⬊ቑṪᅉᏊཷᐜయ 3 ࡢⓎ⌧ஹ㐍㸬➨ 82
ᅇ᪥ᮏ⏕Ꮫ㸬⚄ᡞ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
64. ᐑᕝ┿⏤Ꮚࠊᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊᘅ㔝⏤㔛Ꮚࠊబṇ᫂ࠊ➉ෆࠊࢣࣥࢺ࣭
ࣆ࣮ࣥ࢝ࢺࣥࠊ➉ෆᐇ㸬࢞ࣜࢡࢫⲖ⇕Ỉᢳฟᾮࡼࡿዲ୰⌫ࡢ㉮άᛶࡑࡢ
᭷ຠᡂศ㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
65. ᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊబṇ᫂ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊ➉ෆᐇ㸬LPS ⤒
㰯ᢞࡼࡿ⫵⅖ࡢㄏᑟዲ୰⌫ᶵ⬟ࡘ࠸࡚㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ
⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
66. ᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊబṇ᫂ࠊᕝῧᙬ㤶ࠊ㔜ྜྷ⍛㔛ࠊ✄㈡ࡍࡳࢀࠊᯇ
⏣ಟࠊ㛗ⱌᏊࠊ➉ෆࠊࢣࣥࢺ࣭ࣆ࣮ࣥ࢝ࢺࣥࠊ➉ෆᐇ㸬ࢱࣂࢥὶ↮ࡼ
ࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA ᦆയࡑࡢಟ㸬➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ
⛅ᏘᏛ⾡㸬ᮾி㸬ᖹᡂ 22 ᖺ 11 ᭶㸬
67. 㔜ྜྷ⍛㔛ࠊᕝῧᙬ㤶ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊబṇ᫂ࠊ➉ෆᐇ㸬⻏⻤
ࡼࡿᢠయ⏘⏕ᶵ⬟ࡢᙳ㡪㸬
➨ 60 ᅇ᪥ᮏࣞࣝࢠ࣮Ꮫ⛅ᏘᏛ⾡㸬
ᮾி㸬
ᖹᡂ 22 ᖺ 11 ᭶㸬
68. Mayuko Miyagawa, Ayaka Kawazoe, Eri Shigeyoshi, Yuriko Hirono, Toru Takeuchi,
45
−80−
K.E. Pinkerton and Minoru Takeuchi. Induction of neutrophils in LL/2 tumor bearing
mice. ➨ 69 ᅇ᪥ᮏ⒴ᏛᏛ⾡⥲㸬㜰㸬ᖹᡂ 22 ᖺ 9 ᭶㸬
69. M. Miyagawa, A. Kawazoe, E. Shigeyoshi, Y. Hirono, M. Sakura, T. Takeuchi, K.E.
Pinkerton, M. Takeuchi. HOT WATER EXTRACT OF AGARICUS BLAZEI
MURILL (ABM) PREVENTS THE AGEING PROCESS BY ACTIVATION OF
NEUTROPHIL FUNCTIONS. THE 1st INTERNATIONAL CONGRESS ON
CONTROVERSIES IN LONGEVITY, HEALTH AND AGING㸬ࣂࣝࢭࣟࢼ㸬ᖹ
ᡂ 22 ᖺ 6 ᭶㸬
70. Y. Hirono, S. Inoue, M. Miyagawa, T. Ishida, M. Sakura, S. Inaga, O. Mazda, S.
Nagai, T. M. Takeuchi Cigarette Smoke Induces DNA Damage but not Apoptosis in
Alveolar Macrophages. American Thoracic society (ATS) ATS 2010 International
Conference. ࢽ࣮࣮ࣗ࢜ࣜࣥࢬ㸬ᖹᡂ 22 ᖺ 5 ᭶㸬
71. G. Walter Canonica, Carlos E. Baena-Cagnani. e Minoru Takeuchi MEDIMOND
INTERNATIONAL PROCEEDINGS. World Allergy Congress WAC, 132 pages,
2009.
72. M. Miyagawa, S. Inoue, Y. Hirono, T. Ishida, M. Sakura, T. Takeuchi, Y. Hoshishima,
K.E. Pinkerton, M. Takeuchi. FFECT OF HOT WATER EXTRACT FROM
AGARICUS BLAZEI MURILL ON IMMUNE FUNCTIONS. XXI World Allergy
Congress (WAC). ࣈ࢚ࣀࢫࣞࢫ㸬ᖹᡂ 21 ᖺ 12 ᭶㸬
73. Shinichi Inoue, Yuriko Hirono, Mayuko Miyagawa, Takahiro Ishida, Osamu Mazda,
Sonoko Nagai, Toru Takeuchi, K.E. Pinkerton, M Takeuchi. Effect of Side-stream
Tobacco Smoke on DNA Damage in Alveolar Macrophage. ➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ
⾡⥲㸬ᶓ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
74. Mayuko Miyagawa, Shinichi Inoue, Hirono Yuriko, Takahiro Ishida, Masaaki Sakura,
Toru Takeuchi, Yuichi Hoshishima, Kent E. Pinkerton, Minoru Takeuchi. The
mechanism of anti-tumor activity in induced immune cells by hot water extract from
Agaricus blazei Murill.➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ⾡⥲㸬ᶓ㸬ᖹᡂ 21 ᖺ 10 ᭶㸬
75. Yuriko Hirono, Shinichi Inoue, Mayuko Miyagawa, Takahiro Ishida, Sumire Inaga,
Tomonori Naguro, Osamu Mazda, Sonoko Nagai, Toru Takeuchi, K.E. Pinkerton,
Minoru Takeuchi. Repair of DNA Damage in Alveolar Macrophages Induced by
Cigarette Smoke Exposure. ➨ 68 ᅇ ᪥ᮏ⒴ᏛᏛ⾡⥲㸬ᶓ㸬ᖹᡂ 21 ᖺ 10
᭶㸬
76. M Takeuch, Y Hirono, M Miyagawa, S Inoue, T Ishida, S Nagai, K E Pinkerton. The
mechanism of inhibition of immune function in Alveolar Macrophage (AM) by
smoking. The 49th Annual Meeting of The Japanese Respiratory Society. ᮾி㸬ᖹᡂ
21 ᖺ 6 ᭶㸬
77. A. Ross, K.E. Pinkerton, M. Takeuchi. Neonatal Murine Sensitivity to Influenza
Infection Is Enhanced by Perinatal Exposure to Environmental Tobacco Smoke.
American Thoracic society (ATS) ATS 2008 International Conference. ࢧࣥࢹ࢚
ࢦ㸬ᖹᡂ 21 ᖺ 5 ᭶㸬
78. M. Takeuchi, Y. Hirono, M. Miyagawa, S. Inoue, T. Ishida, S. Inaga, T. Naguro, T.
46
−81−
Takeuchi, S. Nagai, K.E. Pinkerton. Inhibition of immunological functions in alveolar
macrophages (AM) related with DNA damage by cigarette tobacco smoke exposure.
American Thoracic society (ATS) ATS 2008 International Conference. ࢧࣥࢹ࢚
ࢦ㸬ᖹᡂ 21 ᖺ 5 ᭶㸬
79. ୖៅ୍ࠊᘅ㔝⏤㔛Ꮚࠊᐑᕝ┿⏤Ꮚࠊ▼⏣ႛ⿱ࠊᯇ⏣ಟࠊ㛗ⱌᏊࠊ➉ෆࠊ
K.E.Pinkertonࠊ➉ෆᐇ㸬ὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA ᦆയࡢᙳ
㡪㸬➨ 38 ᅇ ᪥ᮏචᏛ⥲࣭Ꮫ⾡㞟㸬ி㒔㸬ᖹᡂ 20 ᖺ 12 ᭶㸬
80. HIRONO Yuriko, INOUE Shinichi, MIYAGAWA Mayuko, MAZDA Osamu,
NAGAI Sonoko, TAKEUCHI Toru, PINKERTON K.E, TAKEUCHI Minoru.
Cigarette smoke induced DNA damage, but not apoptosis of alveolar macrophages.
➨ 38 ᅇ ᪥ᮏචᏛ⥲࣭Ꮫ⾡㞟㸬ி㒔㸬ᖹᡂ 20 ᖺ 12 ᭶㸬
81. Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Takahiro Ishida, Osamu Mazda,
Toru Takeuchi, K.E. Pinkerton, Minoru Takeuchi. Effect of hot water extract from
Agaricus blazei Murill on chemotaxis of nuetrophils. ➨ 38 ᅇ ᪥ᮏචᏛ⥲࣭
Ꮫ⾡㞟㸬ி㒔㸬ᖹᡂ 20 ᖺ 12 ᭶㸬
82. Hirono Yuriko, Inoue Shinichi, Miyagawa Mayuko, Asada Hidetsugu, Mazda Osamu,
Nagai Sonoko, Takeuchi Toru, Pinkerton K.E, Takeuchi Minoru. igarette smoke
induces DNA damage and inhibition of apoptosis in alveolar macrophages. ➨ 67 ᅇ
᪥ᮏ⒴ᏛᏛ⾡⥲㸬ྡྂᒇ㸬ᖹᡂ 20 ᖺ 10 ᭶㸬
83. Mayuko Miyagawa, Yuriko Hirono, Shinich Inoue, Hidetsugu Asada, Osamu Mazda,
Toru Takeuchi, K.E. Pinkerton, Minoru Takeuchi. Effect of hot water extract from
Agaricus blazei Murill on immue functions and anti-tumor activity. ➨ 67 ᅇ ᪥ᮏ⒴
ᏛᏛ⾡⥲㸬ྡྂᒇ㸬ᖹᡂ 20 ᖺ 10 ᭶㸬
84. ➉ෆᐇࠊ▼⏣ႛ⿱ࠊᘅ㔝⏤㔛Ꮚࠊᑠᯘᝅࠊᐑᕝ┿⏤Ꮚࠊୖៅ୍ࠊ➉ෆࠊ
Kent E. Pinkerton㸬ࢱࣂࢥὶ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪᶵ⬟ࡢᢚไᶵᵓ
ࡘ࠸࡚㸬➨ 146 ᅇ ᪥ᮏ⋇་ᏛᏛ⾡㞟㸬ᐑᓮ㸬ᖹᡂ 20 ᖺ 9 ᭶㸬
85. ᘅ㔝⏤㔛Ꮚࠊᑠᯘᝅࠊ⚟⏣⨾ᶞࠊᐑᕝ┿⏤Ꮚࠊᯇ⏣ಟࠊὸ⏣⚽ᇶࠊ㛗ⱌ
Ꮚࠊ➉ෆࠊK.E. Pinkertonࠊ➉ෆᐇ㸬ႚ↮ࡼࡿ⫵⬊࣐ࢡࣟࣇ࣮ࢪࡢ DNA
ᦆയࡢㄏᑟ࣏ࢺ࣮ࢩࢫࡢᢚไ㸬
➨ 48 ᅇ ᪥ᮏ྾ჾᏛᏛ⾡ㅮ₇㸬
⚄ᡞ㸬
ᖹᡂ 20 ᖺ 6 ᭶㸬
86. M. Takeuchi, K. Kobayashi, Y. Hirono, S. Nagai, K.E. Pinkerton. Cigarette Smoke
Inhibits Antibody Production-Associated with Alveolar Macrophage. American
Thoracic society (ATS) ATS 2008 International Conference. ࢺࣟࣥࢺ㸬ᖹᡂ 20 ᖺ 5
᭶㸬
87. ὠୗⱥ᫂. ཎ⳦ࢆࡉࡽ⌮ゎࡍࡿࡢࡓࡵࡢᵓ㐀⏕≀Ꮫ㸦ⱝᡭࢩ࣏ࣥࢪ࣒࢘㸸
ࡵࡊࡏ㸟⣽⳦Ꮫࡢᫍۼ㸧➨ 86 ᅇ᪥ᮏ⣽⳦Ꮫ⥲㸬༓ⴥ 2013.3.18
88. ⛅ᾈࠊ㭯ᮧಇࠊ␊ᒣࠊⴱཎ㝯ࠊὠୗⱥ᫂㸸ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫRNA
࣏࣓࣮ࣜࣛࢮPB2ࡢX⥺⤖ᬗᵓ㐀ゎᯒ ⏕Ꮫ 2012.12
89. 㭯ᮧಇࠊὠୗⱥ᫂㸸ࣔࣀࢩࣝࢢࣜࢭ࣮ࣟࣝࣜࣃ࣮ࢮࡢ㔞యᙧᡂࡣࡑࡢ
ᶵ⬟㔜せ? ⏕Ꮫ 2012.12
90. Hideaki Tsuge, Toshiharu Tsurumura, Masataka Oda, Masahiro Nagahama 㸸Actin
47
−82−
Recognition and ADP-ribosylation of C. perfringens iota-toxin The 11th Awaji
International Forum on Infection and Immunity 2012.9.13
91. 㭯ᮧಇࠊὠᏲ⪨Ⰻࠊ⛅ᾈࠊὠୗⱥ᫂㸸ࢡࢳࣥ ADP ࣜ࣎ࢩࣝᛂక
࠺㓝⣲ࡢᵓ㐀ኚࢱࣥࣃࢡ㉁⛉Ꮫ 2012.6
92. ὠୗⱥ᫂㸸 ADP ࣜ࣎ࢩࣝẘ⣲ᵓ㐀◊✲ࡢ᭱๓⥺ ࢩ࣏ࣥࢪ࣒࢘ࠕᝈ
⒪⏝࠸ࡿኳ↛᭷ᶵྜ≀ࡢ⏕ྜᡂ㑇ఏᏊࡢໟᣓⓗ⌮ゎࠖᚨᓥᩥ⌮Ꮫࠊ
2011.12.22
93. ὠୗⱥ᫂㸸ࢡࢳࣥ ADP ࣜ࣎ࢩࣝࡢᵓ㐀ᇶ┙ ࢩ࣏ࣥࢪ࣒࢘ࠕADP ࣜ࣎
ࢩࣝࡼࡿࢩࢢࢼࣝఏ㐩ไᚚࠖ⏕Ꮫࠊி㒔ᅜ㝿㤋ࠊ2011.9.21
94. ὠୗⱥ᫂㸸ឤᰁᅉᏊࣄࢺࢱࣥࣃࢡ㉁ࡢ┦స⏝ࢆぢࡿ㸸X ⥺ࡢࠊ㜰ᛴ
ࢢࣛࣥࢻࣅࣝ 26 㝵ࠊ2011.9.10
95. Tsurumura T., Tsuge H.㸸Crystal structure of Ia-Actin complex with novel ligand ᅜ
㝿⤖ᬗᏛ Madrid, 2011.8.25-26
96. Tsurumura T., Tsuge H.㸸Structural basis for the Helicobacter pylori-carcinogenic
TNF-alpha-inducing protein ᅜ㝿⤖ᬗᏛ Madrid, 2011.8.25-26
97. 㭯ᮧಇࠊὠୗⱥ᫂㸸ADPࣜ࣎ࢩࣝẘ⣲ࡼࡿࢡࢳࣥㄆ㆑ࡢ≉␗ᛶゎᯒ
᪥ᮏ⺮ⓑ㉁⛉Ꮫ, 㜰ᗓ྿⏣ᕷࠊ2011.6.7-9
98. ᕝ㈗ோࠊὠୗⱥ᫂㸸㧗ᗘዲ⇕⳦HB8⏤᮶ࡢࣇࣛࣅࣥ㑏ඖ㓝⣲ࡢᵓ㐀ᶵ⬟ゎ
ᯒ ࣅࢱ࣑ࣥB◊✲ጤဨ ➨422ᅇ◊✲༠㆟ ி㒔ᕷࠊ2010.11.27
99. ὠୗⱥ᫂㸸ࣔࣀ ADP ࣜ࣎ࢩࣝẘ⣲ࡑࡢᶆⓗࢱࣥࣃࢡ㉁ࢡࢳࣥࡢ」ྜ
యࡢ X ⥺⤖ᬗᵓ㐀ゎᯒ㸸ᅜ❧ࡀࢇࢭࣥࢱ࣮◊✲ᡤࠊ2010.2.22
100. ὠୗⱥ᫂㸸⣽⳦࠾ࡼࡧ࢘ࣝࢫឤᰁࡢᵓ㐀⏕≀Ꮫ ➨㸲ᅇᏛ⾡ࣇࣟࣥࢸ
ࢩ࣏ࣥࢪ࣒࢘
ࠕX ⥺⤖ᬗᵓ㐀ゎᯒ㉁㔞ศᯒࡼࡿ⏕⌮άᛶ⺮ⓑ㉁ࡢᵓ㐀ᶵ
⬟┦㛵ࡢ◊✲ࠖᚨᓥᩥ⌮Ꮫࠊ2010.1.30
48
−83−
ᩥ㒊⛉Ꮫ┬ࠕ⚾❧Ꮫᡓ␎ⓗ◊✲ᇶ┙ᙧᡂᨭᴗࠖ
ࠕ᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ಀࡿ⮬↛⛉Ꮫཬࡧ♫⛉Ꮫ⼥ྜ◊✲ࢩ࣏ࣥࢪ࣒࢘ࠖ
ദ㸸ி㒔⏘ᴗᏛ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮
᪥ 㸸ᖹᡂ㸰㸳ᖺ㸱᭶㸰᪥㸦ᅵ㸧༗ᚋ㸯 ศࡽ㸳 ศࡲ࡛
ሙ ᡤ㸸ி㒔⏘ᴗᏛᅗ᭩㤋࣮࣍ࣝ
ࣉࣟࢢ࣒ࣛ
㛤ࡢ㎡
ᵳ බ୍ ி㒔⏘ᴗᏛ㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮㛗
ᣵ ᣜ
ᇛ ගṇ ி㒔⏘ᴗᏛᏛ㛗
ㅮ ₇
㸯㸬࣋ࢺࢼ࣒࠾ࡅࡿ㫽ࣥࣇ࢚ࣝࣥࢨ࢘ࣝࢫᾐ₶≧ἣ
ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊࣭㫽ࣥࣇ࢚ࣝࣥࢨ◊✲ࢭࣥࢱ࣮ 㧗᱓ ᘯᶞᩍᤵ
㸰㸬᪂ᆺࣥࣇ࢚ࣝࣥࢨᑐ⟇ேᶒ
̿᪂ᆺࣥࣇ࢚ࣝࣥࢨ➼ᑐ⟇≉ูᥐ⨨ἲࡢ⾜ࢆ๓̿
ྠᚿ♫ᏛἲᏛ㒊࣭ἲᏛ◊✲⛉ ᕝᮏ ဴ㑻ᩍᤵ
㸱㸬࣋ࢺࢼ࣒࠾ࡅࡿᛴᛶᑠඣୗ⑩ࡢ◊✲
㛗ᓮᏛ⇕ᖏ་Ꮫ◊✲ᡤࢪ࣭ࣇࣜ࢝ឤᰁ◊✲タࠊ་ṑ⸆Ꮫ⥲ྜ◊✲⛉ࠊ 㛗ᓮᏛ࣋ࢺࢼ࣒ᣐⅬ ᣐⅬ㛗 ᒣᇛ ဴᩍᤵ
㸲㸬㑇ఏᏊᨵኚࡼࡿᢠᛶື≀ࡢ㛤Ⓨ㸸⣽⬊ࠊ࣐࢘ࢫࡽࣈࢱ
ᕞᏛᏛ㝔་Ꮫ◊✲㝔ᐇ㦂ື≀Ꮫศ㔝 ᑠ㔝 ᝋ㑻ᩍᤵ
㛢ࡢ㎡
୰⏣ ༤ ி㒔⏘ᴗᏛ⥲ྜ⏕⛉Ꮫ㒊ᩍᤵ
−84−
平成20年度∼平成24年度私立大学戦略的研究基盤形成支援事業 研究成果報告書
「新型インフルエンザ対策に係る自然科学及び社会科学融合研究」
平成25年5月
発行 京都産業大学
鳥インフルエンザ研究センター
〒603-8555 京都市北区上賀茂本山
印刷 株式会社田中プリント