単色 X 線を用いた Superabsorbent polymer microsphere - SPring-8
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単色 X 線を用いた Superabsorbent polymer microsphere - SPring-8
2007A1851 BL20B2 න⦡ : ✢ࠍ↪ߚ 5WRGTCDUQTDGPVRQN[OGT OKETQURJGTG 5#2/KETQURJGTGߩᒻᘒᄌൻߦ㑐ߔࠆၮ␆⊛⎇ⓥ Experimental study of transformation behavior of Superabsorbent polymer microsphere(SAP-Microsphere) with monochromatic X-rays ⼱ᧄ ᄢ๋ޔጊᧄ ੫ޔዊ⇗ ’ੱޔ ⨃᮸ Daigo Tanimoto, Akira Yamamoto, Makito Kobatake, Shigeki Imai Ꮉፒක⑼ᄢቇ Kawasaki Medical School ࠕࡉࠬ࠻ࠢ࠻ ࿁ᚒߪޘන⦡㨄✢ࠍ↪ߡ↢ℂ㘩Ⴎ᳓ࡦࠝࠗޔᕈㅧᓇ㧔*GZCDTKZ£ 㧕ޔ㕖ࠗࠝࡦᕈㅧᓇ 㧔8KUKRCSWG£㧕ߩߘࠇߙࠇࠍๆߐߖߚ 5#2/KETQURJGTG ߩⴊ▤ౝᵈᓟߩᒻᘒᄌൻࠍ↢ਅߦ ⷰኤߔࠆߎߣߦᚑഞߒߚ⚿ޕᨐ↢ޔℂ㘩Ⴎ᳓ࠍๆߐߖߚ 5#2/KETQURJGTG ߪᵈᓟᄢ߈ߐߦᄌൻߪ ߥ߆ߞߚࡦࠝࠗޕᕈㅧᓇࠍๆߐߖߚ 5#2/KETQURJGTG ߪᵈ⋥ᓟ⤘ᒛߒߚ৻ޕᣇޔ㕖ࠗࠝࡦᕈㅧ ᓇࠍๆߐߖߚ 5#2/KETQURJGTG ߪᵈ⋥ᓟ❗ዊߒߚޕ࿁ߩታ㛎ߢߪߎࠇࠄߩ․ᓽ⊛ߥᄌൻࠍ↹ ߦߣࠄ߃ⷰߦ⊛ⷡⷞޔኤߔࠆߎߣ߇ߢ߈ߚߒ߆ߒޕႧᩖ‛⾰ߣⴊ▤ߩࠦࡦ࠻ࠬ࠻߇ߟ߈ߦߊߊ☸ ሶᓘߩ⸘᷹߇࿎㔍ߢ⤘ᒛ₸ࠍ᷹ቯߔࠆߎߣߪߢ߈ߥ߆ߞߚޕ Abstract We succeeded in observing the transformation behavior of SAP-Microsphere which had absorbed serum saline or ionic contrast media (Hexabrix 320£) or non-ionic contrast media (Visipaque 270£) by using monochromatic X-rays in vivo. SAP-MS which absorbed serum saline did not change the form after injection. The SAP which absorbed ionic contrast media expanded the volume after injection. On the other hand, SAP which absorbed non-ionic contrast media reduced the volume after injection. We succeeded in depicting the transformation behavior. However, we could not measure the diameter of SAP, because borderline of SAP and contrast media was unclear. ⢛᥊ߣ⋡⊛㧦 ࠅ㜞Ⴇᩖലᨐࠍ⊒ើߔࠆߎߣ߇ߎࠇ߹ߢߩ⎇ 㜞ๆ᳓ᕈ 5#2/KETQURJGTG ߪࠕࠢ࡞㉄࠽࠻ ⓥߢ⚵❱ቇ⊛ߦ⏕߆ࠄࠇߡࠆ ޕ ࠙ࡓߣࡆ࠾࡞ࠕ࡞ࠦ࡞ߩ㊀วࠃࠅߥࠆ ᧄ⎇ⓥߩ⋡⊛ߪ 5#2/KETQURJGTG ࠍ↪ߚႧ ⁁☸ሶߢࠆޕᶧࠍ✭ᓢߦๆߞߡ⤘ࠄᕈ⾰ ᩖ ⴚࠍᣉⴕߒ↢ޔਅߦᓸዊⴊ▤ౝߢߩ ࠍߒߡࠆ߇ޔๆߐߖࠆᶧߦࠃࠅ⤘ᒛ₸ 5#2/KETQURJGTG ߩᒻᘒᄌൻࠍ⚻ᤨ⊛ߦ⹏ଔߔ ߇⇣ߥࠆ․ߩߘޕᓽࠍ↢߆ߒⴊ▤Ⴇᩖⴚߦ↪ ࠆߎߣߢࠆޕ ࠆႧᩖ‛⾰ߣߒߡᵈ⋡ߐࠇޔ᰷☨ߢߪߔߢߦ⥃ ᐥߢ߽↪ࠄࠇߡࠆޕේᧃᓘߦኻߒߡࠗࠝࡦ ታ㛎㧦 ᕈㅧᓇߩ *GZCDTKZ£ ↰ㄝ⮎ߢ⚂ ޔ ↢ ℂ 㘩 Ⴎ ᳓ ࠍ ๆ ߐ ߖ ߚ 5#2/KETQURJGTG ↢ℂ㘩Ⴎ᳓㨯ⴊᷡߢ ߦ⤘ᒛߔࠆߚޔ )TQWRࡦࠝࠗޔᕈㅧᓇ *GZCDTKZ£ࠍๆ *GZKCDTKZ£ ࠍๆߐߖߚ 5#2/KETQURJGTG ߐߖߚ 5#2/KETQURJGTG )TQWRޔ㕖ࠗࠝࡦ ࠍⴊ▤ౝߦᵈߔࠆߣೋᦼ☸ሶᓘߣห╬ߩⴊ▤ ᕈ ㅧ ᓇ 8KUKRCSWG£ ࠍ ๆ ߐ ߖ ߚ ߦ⇐߹ࠅⴊߢߎߘޔᷡࠍๆ⤘Ảߔࠆߎߣߢࠃ 5#2/KETQURJGTG )TQWRߩ ⒳㘃ߩႧᩖ‛⾰ࠍ − 40 − ኅᱜᏱ⡊േ⣂ౝߦᵈߔࠆߎߣߦࠃࠅႧᩖ ⴚࠍᣉⴕߒޔᵈ⋥ᓟ߆ࠄ ಽᓟ߹ߢࠍ ಽ㑆 㓒ߢⴊ▤ㅧᓇ߹ߚߪㅘⷞᓇߒޔႧᩖ‛⾰ߩᒻᘒ ᄌൻࠍ↢ਅߦⷰኤߒߚޕㅧᓇ߅ࠃ߮Ⴇᩖⴚߦߪ ࠗࡦࠫࠚࠢ࠲ࠍ↪ߡ৻ቯߩㅦᐲߢⴕߞߚޕ ⚿ᨐ㧦 ߶߷ోߦ߅ߡᓸዊⴊ▤ౝߩႧᩖ‛⾰ࠍឬ ߢ߈ߚޕᵈᓟ ಽ㑆ߩⷰኤߢ )TQWR Ⴇᩖ⟲ ߢߪ☸ሶᓘߦ߶߷ᄌൻ߇ߥ߆ߞߚ)ޕTQWR Ⴇᩖ ⟲ߢߪᵈ⋥ᓟߣᲧセߒߡ☸ሶᓘ߇Ⴧᄢߔࠆ ะߦߞߚ㧔(KI㧕)ޕTQWR Ⴇᩖ⟲ߢߪᵈ⋥ ᓟߣᲧセߒߡ☸ሶᓘ߇❗ዊߔࠆะߦߞߚޕ Fig.1(b) ⠨ኤ㧦 The angiography of immediately after (a) and 10 minutes ࿁ᚒߪޘೋߡ↢ਅߦᓸዊⴊ▤ౝߩ after (b) injection of Group 2 SAP-Microsphere. 5#2/KETQURJGTG ࠍឬߔࠆߎߣߦᚑഞߒߚߐޕ ࠄߦޔᵈ೨ߦๆߐߖࠆᶧߦࠃࠅ⇣ߥࠆᓸ ᓟߩ⺖㗴ߣߘߩዷᦸ㧦 ዊⴊ▤ౝߢߩ 5#2/KETQURJGTG ߩᒻᘒᄌൻࠍ⚻ ࿁ߩ↢ਅߦ߅ߌࠆ⹏ଔߪߎࠇ߹ߢߩ⚵❱ቇ ᤨ⊛ߦⷰኤߔࠆߎߣ߇ߢ߈ߚ❱⚵ߢ߹ࠇߎޕቇ ⊛ߥ⹏ଔߦḰߓߚะࠍ␜ߒߡߚ߇ޔᓟⴊ ⊛ߦ⸽ߒߚႎ๔ߪࠆ߇↢ޔਅߦห৻ ▤ౝߩㅧᓇߣߩࠦࡦ࠻ࠬ࠻ࠍ⍎ߦߔࠆߎ ߢ 5#2/KETQURJGTG ߩᒻᘒᄌൻࠍⷰኤߒߚߎߣ ߣߦࠃࠅ☸ޔሶᓘࠍᱜ⏕ߦ᷹ቯߒߎࠇ߹ߢߩ⚿ ߪ࿁ߩᚒ⎇ߩޘⓥ߇ೋߡߢࠆޕ࿁ߩ⚿ ᨐߣᲧセ⹏ଔߒޔ5#2/KETQURJGTG ߩႧᩖ⢻ജ ᨐߪᓟ⥃ᐥߦ߅ߌࠆႧᩖⴚࠍⴕ߁ߦ߅ߡ ࠍ⏕ߦߔࠆᔅⷐ߇ࠆޕ ߽㊀ⷐߥᖱႎߣߥࠆߎߣߣ੍᷹ߐࠇࠆޕ ෳ⠨ᢥ₂㧦 Hori S., Okada A., Sakamoto K., et al. A new embolic material: superabsorbent polymer microsphere and its embolic effects. Jpn J Intervent Radiol 1996; 11:375–381. (Japanese) ࠠࡢ࠼㧦 SAP-Microsphereޔmonochromatic X-raysޔTAE Fig.1(a) − 41 −