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クリプトコッカス症[PDF File]
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( + » -+ ¼ +0 _ +0 : "Gt"³7 u´&TV=sF, TVs&y)4µ/567 [=H , The Journal of AIDS Research Vol. 0 + / HIV 38?@ ²,= !"#$% &' !"#() *+,-% ./01 234567 [\ RQST 45: +**ῌ% ?@ 2+.2ῌ% ³O FLCZ ,**ῌ.** mgῌ[% §¨ ITCZ ,**ῌ.** mgῌ[% §¨ FLCZ .** mg ῌ [ ´ /-FC +** ῌ +/* mgῌkgῌ[ῌ\ . +* AII CII CII ?45 Gµ1= 2 DEB18F +**ῌ : G' 33ῌ= H [\ ./RSTῌ&F,UVW -% XY Z8F:) 0 AMPH-B *.1ῌ+.* mgῌkgῌ[´/-FC +** mgῌkgῌ[ῌ\ . , % ¶ & FLCZ .** mgῌ[ +* DE RQST AMPH-B *.1ῌ+.* mgῌkgῌ[´/-FC +** mgῌkgῌ[ῌ\ . 0ῌ+* AMPH-B *.1ῌ+.* mgῌkgῌ[ 0ῌ+* AI FLCZ .**ῌ2** mgῌ[ +*ῌ+, ITCZ .** mgῌ[ +*ῌ+, Lipid mulation of AMPH-B -ῌ0 mgῌ kgῌ[ 0ῌ+* CI CII CII [\]T!^_B" + `8C 1= += ?@ #@a:bF$c%&de: HIV f:4 5ghiVj'1,-% &(T!)#) kl> T!*1 +,mnopqF -V T! ./45g hi 0r:$% s 1E tuv>w./? 01xT !2r yz8{+<kl<% |38C F :) ,= ?45 T!XYm}~ 45)-2= BkV W: T!8 AMPH-B *.1 mg ῌ kg ῌ day 67 Gn,*,= /-FC 8 Gn+13= : , T! GZ± 1= >$ T!^_ ?@ 2+.2ῌ :$% 4ABC23 ) bD NO?EP8) :Q: ,**. ?@ 869: ;<0= >./ % ?@:- IJ1KL@ M No. + 45& BI CI £UT! [\ FLCZ ,**ῌ.** mgῌ[% §¨ RQST ITCZ ,** mgῌ[% §¨ AMPH-B + mg/kg +ῌ- times/week, §¨ AI BI CI *FLCZ : Fluconazole, ITCZ : Itraconazole, AMPH-B : Amphotericin B, /-FC : Flucytosine *AMPH-B Lipid formulation ] ^ · : ¸ ¨ _ ` ¹ AIDS T!Cº»a http : //www.iijnet.or.jp/aidsdrugmhwῌ:b ¼j' T!8C% - 2 B FLCZ .** mgῌday Gn+/+= ITCZ .** mg Gn+//= :T!84A L01 VW`]% - FG@ x9v>wSXYm-8C , . 4AL E@῍ ]% CHI JK<% @ H 01x9 /-FC 8,bC G0*ῌ vs /+ῌ, p D0B[\8) LM Nf% *.*0= +* . 4AL01x9 FLCZ 1,ῌ, ITCZ 0*ῌ c?@ ῍,O G :Q,bC NO:SXY" )9= V23)9¡)238)#) :+<)bC &;8 <9} kl< CD. /* ῌ mL D , : /./ῌ% - 2 : -.3ῌ :bC T!*(: AMPH-B 4=>?Fkl< :H@:) A4AB84AB +**ῌ,** mgῌday @(BP¢ FLCZ >?B-V ,= QD0 G£UT!= 45T!& f% ¤ED0 C+&(£UT ]C% *.+ mgῌ*.,/ mgῌ- mL B8CCB ! )#) FLCZ 4=>?V WB ,ῌ- i :£UT!§¨Vb©]W[\] 1 += HD0 CD. >?RHST:$% ¥¦U FLCZ WX1,-% .** mgῌday 6ª9 Y>?:F @(JK#->?B©: H% HAART >b CD. ,)bCf:% £UT! fKLB>?VW:E@῍ B2r8F¤E«<)¬®¯° +1 G +1 = K Teruya : Cryptococcosis 3, +* . CD. infected persons©,**,. Recommendations of the U.S. ,**ῌ mL 0 Public Health Service and the Infectious Diseases Society !" #$%&'()*+,-./% 01234 of America. MMWR Recomm Rep /+ (RR-2) : +ῌ/,, 5.6789 C :Optional -$, CD. ,**,. .;<=>?@AB CDEFGH&I / Metta HA, Corti ME, Negroni R, et al : Disseminated 23JK.LM$, NOP*(QRSTU)2I cryptococcosis in patients with AIDS. Clinical, micro- V/ - WXI2; I2Y CD. 0.*ῌ mL biological, and immunological analysis of /+ patients. Z++ Rev Argent Microbiol -. : ++1ῌ+,-, ,**,. 0 ª«¬ ®«¯ °±²³ ´ : *(QRST* 2 )2µ¶·¸¹ \]º ,0 : ,10ῌ,2- +32/. [\]^ !B_Z$%]`ab,c2 1 van der Horst CM, Saag MS, Cloud GA, et al : Treat- HAART Xde&fg2hiI2Bjk.lmn ment of cryptococcal meningitis associated with the ac- o HAART pqXBDrst.uv22w quired immunodeficiency syndrome. National Institute xyB_z{2w|}~/M of Allergy and Infectious Diseases Mycoses Study Group *(QRSTU)-Y, B HAART pq +* 3" / 3de&fg and AIDS Clinical Trials Group. N Engl J Med --1 : +/ῌ,+, +331. -JK+, , 3Est]PD 2 Saag MS, Graybill RJ, Larsen RA, et al : Practice guide- vI2 + 3( + 3E*(Q lines for the management of cryptococcal disease. Infec- RSTU)VH + 3BFGH tious Diseases Society of America. Clin Infect Dis -* : Z - 3B,$0*(QRSTU)L M 3¡PZ M/ HAART pq X ,ῌ++ XBZ$, 1+*ῌ1+2, ,***. 3 Kirk O, Reiss P, Uberti-Foppa C, et al : Safe interruption of maintenance therapy against previous infection Trevenzoli /% ¢P*(QRSTU)2£¤ with four common HIV-associated opportunistic patho- HAART pqXBI2 *(QRSTU) gens during potent antiretroviral therapy. Ann Intern v - 3JK$,+- HAART pqX¥¦ 3* § Med +-1 : ,-3ῌ,/*, ,**,. IV; :0*ῌ+/* § 3 FLCZ ! +* Vibhagool A, Sungkanuparph S, Mootsikapun P, et al : Z$, (0B_; ¨M$, Discontinuation of secondary prophylaxis for crypto- coccal meningitis in human immunodeficiency virus- infected patients treated with highly active antiretroviral + Kaplan JE, Hanson D, Dworkin MS, et al : Epidemiology of human immunodeficiency virus-associated op- therapy : a prospective, multicenter, randomized study. Clin Infect Dis -0 : +-,3ῌ+--+, ,**-. portunistic infections in the United States in the era of ++ Rambeloarisoa J, Batisse D, Thiebaut JB, et al : highly active antiretroviral therapy. Clin Infect Dis -* Intramedullary abscess resulting from disseminated Suppl + : S/ῌ+., ,***. cryptococcosis despite immune restoration in a patient , European Confederation of Medical Mycology (ECMM) prospective survey of cryptococcosis : report from Italy. Med Mycol .* : /*1ῌ/+1, ,**,. - Mirza SA, Phelan M, Rimland D, et al : The changing epidemiology of cryptococcosis : an update from population-based active surveillance in , large metropolitan areas, +33,ῌ,***. Clin Infect Dis -0 : 123ῌ13., ,**-. . USPHS ; Infectious Disease Society of America : Guidelines for preventing opportunistic infections among HIV- +2 : +2 with AIDS. J Infect .. : +2/ῌ+22, ,**,. +, Jenny-Avital ER, Abadi M : Immune reconstitution cryptococcosis after initiation of successful highly active antiretroviral therapy. Clin Infect Dis -/ : e+,2ῌ+--, ,**,. +- Trevenzoli M, Cattelan AM, Rea F, et al : Mediastinitis due to cryptococcal infection : a new clinical entity in the HAART era. J Infect ./ : +1-ῌ+13, ,**,.