動物実験を用いた研究成果

動物実験を用いた研究成果
発表論文等
（Ｈ２３年度，Ｈ２４年度，Ｈ２５年度，Ｈ２６年度，Ｈ２７年度）
Matsubara T, Ikeda M, Kiso Y, Sakuma M, Yoshino K, Sakane F, Merida I, Saito N, Shirai Y , 2012, c-Abl tyrosine
kinase regulates serum-induced nuclear export of diacylglycerol kinase by phosphorylation at Tyr-218., J Biol
Chem 287: 5507-5517
Kajimoto, K., Shao, D., Takagi, H., Maceri, G., Zablocki, D., Mukai, H., Ono, Y., and Sadoshima, J.,
2011,Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes., Am J Physiol
Heart Circ Physiol. 300 巻 H191-200.
Sehrawat, S., Ernandez, T., Cullere, X., Takahashi, M., Ono, Y., Komarova, Y., and Mayadas, T.N.,2011, AKAP9
regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties.,Blood 117 巻 708 718.
Yasuda, H., and Mukai, H,. Electorphysiological technique for the analysis of the synaptic function of PKN1 in the
hippocampus.
Neuromethods（共著）,Springer, 2012 年
Yamazaki, K., Suzuki, M., Itoh, T., Yamamoto, K., Kanemitsu, M., Matsumura, C., Nakano, T., Sakaki, T., Fukami,
Y., Imaishi, H., and Inui, H. (2011) Structural basis of species differences between human and experimental animal
CYP1A1S in
metabolism of 3,3’,4,4’,5-pentachlorobiphenyl. J. Biochem. 149(4), 487-494.
Kushima, S., Mammadova, G., Hasan, A.K.M. M., Fukami, Y., and Sato, K.-I. (2011)
Lipovitellin 2 as a Tyrosine- phosphorylated Protein in
Oocytes,Eggs, and Early Embryos of Xenopus laevis. Zoological Sci. 28, 550-559.
Characterization of
Lisa, L. A., Elias, S. M., Rahman, M. S., Shahid, S., Iwasaki, T., Hasan, A.K.M. M., Kosuge, K., Fukami, Y., and
Seraj, Z. I. (2011) Physiology and gene expression of The rice landrace Horkuch under salt stress. Func. Plant Biol.
DOI:10.1071/FP10198
Mahbub Hasan AK, Fukami Y, Sato K.-I. (2011) Gamete membrane microdomains and their associated molecules
in fertilization signaling. Mol Reprod Dev. Oct-Nov;78(10-11):814-30.
Tokmakov AA, Iguchi S, Iwasaki T, Fukami Y. (2011) Unfertilized frog eggs die by apoptosis following meiotic
exit. BMC Cell Biol. Dec 23;12(1):56.
Sakaguchi M, Oka M, Iwasaki T, Fukami Y, Nishigori C. (2012) Role and Regulation of STAT3 Phosphorylation at
Ser727 in Melanocytes and Melanoma Cells. J Invest Dermatol. 2012 Mar 15. doi: 10.1038/jid.2012.45.
Persorption of IgG-Fc-coated particulates from intestinal lumen into portal blood via villous columnar epithelial
cells in rat small intestine. Yuji, M., Fujimoto, M., Qi, W.-M., Takahara, E., Mantani, Y., Udayanga, K. G. S.,
Takeuchi, T., Warita, K., Yokoyama, T., Hoshi, N., Kitagawa, H. The Journal of Veterinary Medical Science,
accepted, (2012).
Immunohistochemical detection of Toll-like receptor-2, -4 and -9 in exocrine glands from exocrine glands
associated with the rat alimentary tract. Mantani, Y., Yokoo, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E.,
Takeuchi, T., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H. The Journal of Veterinary Medical Science,
accepted, (2012).
Alteration in the apoptosis process of rat esophageal epithelium with hyperproliferation of indigenous bacteria
under a physiological condition. Udayanga, K. G. S., Yamamoto, K., Miayata, H., Yokoo, Y., Mantani, Y.,
Takahara, E., Kawano, J., Yokoyama, T., Hoshi, N. and Kitagawa, H. The Journal of Veterinary Medical Science,
accepted, (2012).
Site differences of the Toll-like receptor expression in the mucous epithelium of rat small intestine. Mantani, Y.,
Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H.
Histology and Histopathology 26, 1295-1303, (2011).
Immunohistochemical and histoplanimetrical study on the special relationship between the settlement of indigenous
bacteria and the secretion of bactericidal peptides in rat alimentary tract. Yokoo, Y., Miyata, H., Udayanga, K. G.
S., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Kawano, J., Hoshi, N., Kitagawa, H. Journal of
Veterinary Medical Science, 73, 1043-1050, (2011).
Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological
condition. Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T.,
Hoshi, N., Kitagawa, H. Histology and Histopathology 26, 811-820, (2011).
Immunohistohemical detection of phosphatidylserine and thrombospondin on denucleating erythroblasts in rat bone
marrow. Yokoyama, T., Etoh, T., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T.,
Takeuchi, T., Hoshi, N., Kitagawa, H. Journal of Veterinary Medical Science, 73, 949-952, (2011).
Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat digestive organs.
Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Yokoyama, T., Kawano, J., Hoshi, N.,
Kitagawa, H. Journal of Veterinary Medical Science, 73, 217-225, (2011).
北川 浩（2011）：第 4 章 血液および骨髄，日本獣医解剖学会 編，獣医組織学
東京．
北川 浩（2011）：第 6 章 免疫学
文永堂出版，東京．
1.免疫系の発生と免疫に関わる組織，見上
改訂第 5 版，学窓社，
彪 監修，獣医免疫学，
Hirashima Y, Moniruzzaman M, Miyano T.,2011.9,p27(Kip1) negatively regulates the activation of murine
primordial oocytes., J Reprod Dev. 57(2): 217-222.
Bao RM, Hayakawa K, Moniruzzaman M, Taketsuru H, Miyano T.,2011.9, FOXO3 knockdown accelerates
development of bovine primordial follicles., J Reprod Dev. 57(4):475-480.
Saneyasu T, Honda K, Kamisoyama H, Ikura A, Nakayama Y, Hasegawa S.,2011.5, Neuropeptide Y effect on food
intake in broiler and layer chicks., Comparative Biochemistry and Physiology Part A: Molecular & Integrative
Physiology, 159 巻, 4 号, p422-p426.
Toshiyuki Nakamura, Ryohei Tanaka, Hitoshi Ashida.,2011.8, Possible evidence of contamination by catechins in
deconjugation enzymes from Helix pomatia and Abalone entrails, Bioscience, Biotechnology and Biochemistry,
75(8), 1506-1510
Yuki Kanamoto, Yoko Yamashita, Fumio Namba, Tadashi Yoshida, Takanori Tsuda, Itsuko Fukuda, Sachiko
Nakamura-Tsuruta, and Hitoshi Ashida.,2011.7, A black soybean seed coat extract prevents obesity and glucose
intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed
mice., Journal of Agricultural Food Chemistry, 59(16), 8985-8993
Itsuko Fukuda, Miki Tsutsui, Tadashi Yoshida, Toshiya Toda, Takanori Tsuda, and Hitoshi Ashida.,2011.9, Acute
and chronic oral toxicity studies of black soybean (Glycine max) hull extract in mice and rats, Food and Chemical
Toxicology, 49(12), 3272-3278
Masaya Kawase, Tadashi Saito, Teruo Yasunaga, Tatsuya Takagi, Itsuko Fukuda, Hitoshi Ashida.,2012.2, New
structure descriptor in structure-activity relationship study in the suppression of the aryl hydrocarbon receptor
transformation by anthraquinones, Food Science and Technology Research, 18(2), 173-176
Shin Nishiumi, Keizo Hosokawa, Masaki Anetai, Toshiro Shibata, Rie Mukai, Ken-ichi Yoshida, Hitoshi
Ashida.,2012.4, Antagonistic effect of the Ainu-selected traditional beneficial plants on the transformation of an
aryl hydrocarbon receptor, Journal of Food Science, 77(4), C420-C429
Noda T, Shidara O, Harayama H.,2012.1, Detection of the activator cAMP responsive element modulator (CREM)
isoform ortholog proteins in porcine spermatids and sperm, Theriogenology 77(7):1360-1368.
Yasuyuki Masuda, Toshinari Takahashi, Kazutoshi Yoshida, Yosuke Nishitani, Masashi Mizuno, and Haruhiko
Mizoguchi, 2012, in press, Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake
is not dependent on the total IgE levels, Journal of Bioscience and Bioengineering
Matsubara, M., Ikeda, M., Kiso, Y., Sakuma, M., Sakane, F., Merida, I, Saito, N. and Shirai, Y.,2012.2, c-Abl
tyrosine kinase regulates serum-induced nuclear export of iacylglycerol kinase a by phosphorylation at Tyr218, J.
Biol. Chem. 287
Shirai, Y., Ikeda, M., Saito, N.,2012.1, Regulation of diacylglycerol kinase by phosphorylation, Adv Biol Regul. 1
Shibata, Y., Kawada-matsuo, M., Shirai, Y., Saito, N., Li, D. and Yamashita, Y.,2011.5, Streptococcus mutans
diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy., J. Medical Microbiol. 60
Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K., Otsuji, C., Sakai, N., Kashiwagi, K., Chida, K., Shirawaka, R.,
Horiuchi, H., Nishigori, C., Ueyama, T. and Saito, N.,2011.4, Direct biding of RalA to PKCh and its crucial role
in morphological change during keratinocytes differentiation, Mol. Biol. Cell 22
Yamanoue, M., Ueda, S., Matsunaga, K., Onishi, K., and Sioyama, N.,2011.8, Characterization of antibodies
against the connectin/titin 20-kDa fragment increased in chicken sarcoplasm during postmortem aging, Proc. 57th
ICoMST, P072
上田修司・山之上
稔,2011.6, 食肉の熟成と筋漿中のコネクチン断片増加, 食肉の科学, 52(1), 120-123
山之上 稔,2011.11, 熟成中の食肉軟化と筋原線維のコネクチンの変化およびパラトロポミオシンの関与,
食肉の科学，52(2), 143-150
Udayanga, K. G. S., Miyata, H., Yokoo, Y., Qi, W.-M., Takahara, E., Mantani, Y., Yokoyama, T., Hoshi, N.,
Kitagawa, H. ,2011, Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under
a physiological condition., Histol Histopathol, 26: 811-820.
Yokoo, Y., Miyata, H., Udayanga, K. G. S., Qi, W.-M., Takahara, E., Yokoyama, T., Kawano, J., Hoshi, N.,
Kitagawa, H.,2011, Immunohistochemical study on the secretory host defense system of bactericidal peptides in rat
digestive organs., JVMS, 73: 217-225.
Yokoyama, T., Etoh, T., Udayanga, K. G. S., Qi, W.-M., Warita, K., Matsumoto, Y., Miki, T., Takeuchi, Y., Hoshi, N.,
Kitagawa, H. ,2011, Immunohistochemical detection of phosphatidylserine and thrombospondin on the
denucleating erythroblasts in rat bone marrow., JVMS, 73: 949-952.
Mantani, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Qi, W.-M., Yokoyama, T., Kawano, J., Hoshi, N.,
Kitagawa, H. ,2011, Site differences of the Toll-like receptor expression in the mucous epithelium of rat small
intestine., Histol Histopathol, 26: 1295-1303.
Udayanga, K. G. S., Yamamoto, K., Miyata, H., Yokoo, Y., Mantani, Y., Takahara, E., Qi, W.-M., Kawano, J.,
Yokoyama, T., Hoshi, N., Kitagawa, H. ,2011, Alteration in the apoptosis process of rat esophageal epithelium with
hyperproliferation of indigenous bacteria un a physiological condition., JVMS, 2011 Dec 22.
Mantani, Y., Yokoo, Y., Kamezaki, A., Udayanga, K. G. S., Takahara, E., Kawano, J., Yokoyama, T., Hoshi, N.,
Kitagawa, H. , 2011（印刷中）, Immunohistochemical study on the secretion of soluble Toll-like receptors from
exocrine glands associated with the rat alimentary tract., Histol Histopathol,
Warita, K., Mitsuhashi, T., Tabuchi, Y., Ohta, K., Suzuki, S., Hoshi, N., Miki, T., Takeuchi, Y. ,2012, Microarray
and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrolexposed testicular Leydig cells., J Toxicol Sci, 37: 287-295.
Brahmajosyula Manjula and MIYAKE Masashi,2011.11, Localization and expression of peptidylarginine deiminase
4 (PAD4) in mammalian oocytes and preimplantation embryos, Zygote, doi:10.1017/S0967199411000633, P1-11
Brahmajosyula Manjula and MIYAKE Masashi, 2012 年 in press, Role of peptidylarginine deiminase 4 (PAD4) in
mammalian preimplantation embryonic development. Zygote, Zygote
Takaichi, R., Odagaki, S-I., Kumanogoh, H., Nakamura, S, Morita, M., Maekawa, S.,2012 Inhibitory effect of
NAP-22 on the phosphatase activity of synaptojanin-1.
, J. Neuroscience Research 90, 21-27.
Nakamura K, Minami K, Tamura K, Iemoto K, Miki T, Seino S. Pancreatic
from non- -cells after birth. Biomed Res 32:167-174, 2011
-cells are generated by neogenesis
Matsubara T, Mita A, Minami K, Hosooka T, Kitazawa S, Takahashi K, Tamori Y, Yokoi N, Watanabe M, Matsuo E,
Nishimura O, Seino S. PGRN is a key adipokine mediating high-fat diet-induced insulin resistance and obesity
through IL-6 in adipose tissue. Cell Metab 15:38-50, 2012
Yokoi, N., Hidaka, S., Tanabe, S., Ohya, M., Ishima, M., Takagi, Y., Masui, N., Seino, S. Role of major
histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats.
Genes Immun 13:139-145, 2012
南幸太郎、清野進：膵 β 細胞におけるインスリン分泌制御メカニズム、最新臨床糖尿病学（上）―糖尿
病学の最新動向－ 日本臨床社 p.95-98, 2012
南幸太郎：膵 β 細胞の機能分化とインスリン分泌細胞の再生誘導、胆と膵 32(11):1219-1225, 2011
柴崎忠雄、清野進：スルホニル尿素薬の新たな標的分子、日本薬理学会雑誌
p.1, 2011
柴崎忠雄、清野進：インスリン分泌における cAMP センサーEpac2A の役割、内科学会雑誌
2011
柴崎忠雄、清野進：インクレチンの分泌調節機構、日本臨床
p.1418-1424,
p.803-807, 2011
柴崎忠雄、安田貴雄、清野進：インスリン開口分泌における Rim2α の役割、糖尿病学 2011 p17-25, 2011
高橋晴美、柴崎忠雄、清野進：新規標的分子 Epac：インスリン分泌における Epac2A の役割、Mebio
28:132-139, 2011
高橋晴美、柴崎忠雄、清野進：インスリン分泌における Epac2A の役割、Diabetes Journal 39:151-157, 2011
N. Hasegawa, A. Sumitomo, A. Fujita, N. Aritome, S. Mizuta, K. Matsui, R. Ishino, K. Inoue, N. Urahama, J. Nose,
T. Mukohara, S. Kamoshida, R. G. Roeder, M. Ito. Mediator subunits MED1 and MED24 cooperatively contribute
to pubertal mammary gland development and growth of breast carcinoma cells. Mol. Cell. Biol. 32, 1483-1495,
2012.4
宇賀昭二：生野菜と寄生虫症. 公衆衛生、76 （1）、47-49、2012.1
宇賀昭二：肝蛭症、肝吸虫症（521-525）、土壌媒介性線虫症（542-546）、感染症事典. 感染症事典編集委
員会（編）、Ohmsha, 2012.1
宇賀昭二（代表編者）：アジアにおける国際保健、神戸大学国際保健教育研究センター発行、ルネック、
2012.1
吉田勉（監修）、栗原伸公（編集）
：公衆衛生学
感染症 121-131）､学文社、2012.1
宇賀昭二
-食物と栄養学基礎シリーズ-、宇賀昭二（環境衛生 19-31；
丸山治彦（編集）：寄生虫学研究；材料と方法（ISBN978-4-88361-998-6）
三恵社、2012.6
青山倫子、宇佐美眞、上田敬博、小谷穣治,2012.2, エンドトキシン血症下の肺好中球アポトーシスへの静
脈注射用免疫グロブリンの効果, 日本外科感染症学会雑誌 9 巻 1 号 63-69 頁
青山倫子、神前雅彦、井上岳人、前重伯壮、三好真琴、上田敬博、宇佐美眞、小谷穣治,2011.11, 自然免
疫系の解析と病態制御 エンドトキシン血症時の性差による IL-18 の役割と腸管 iNOS 発現の差異, エンド
トキシン・自然免疫研究 14 巻 1-5 頁
坂木宏衣、三好真琴、飯塚宣仁、宇佐美悠、青山倫子、宇佐美眞,2011.11, 経口投与によるエンドトキシ
ン誘発肝障害の抑制, 機能性食品と薬理栄養 6 巻 6 号 337-342 頁
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T,
Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y.,2011.8, Ablation
of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.,
PLoS ONE 6:e23238
木戸良明、柴崎忠雄、清野進,2011, 中外医学社, 膵 β 細胞における cAMP 情報伝達系
松田友和、木戸良明,2011, 診断と治療社, 膵 β 細胞における小胞体ストレスの役割
松田友和、木戸良明,2012, 中外医学社, ER stress と膵 β 細胞
木戸良明,2012, 神戸大学国際保健教育研究センター, アジアにおける糖尿病
森藤武，村上慎一郎，椎名祥子，藤田直人，近藤浩代，藤野英己．自然発症２型糖尿病ラットの血糖及
び骨格筋内微小血管障害に対する継続的な持久運動の予防効果．日本基礎理学療法学会誌 15(2): 22-27,
2012.
藤田直人，村上慎一郎，藤野英己．廃用性筋萎縮の予防に対する治療的電気刺激を用いた等尺性収縮の
効果．日本物理療法学会会誌，in press
Fujino H, Kondo H, Murakami S, Nagatomo F, Fujita N, Takeda I, Ishihara A, Roy RR.Differences in Capillary
Architecture, Hemodynamics, and Angiogenic Factors in Rat Slow and Fast Plantarflexor Muscle. Muscle Nerve
45(2): 242-249, 2012.
Fujita N, Murakami S, Fujino H. The combined effect of electrical stimulation and high-load isometric contraction
on protein degradation pathways in muscle atrophy induced by hindlimb unloading. J Biomed Biotechnol 2011:
401493, 2011.
長井桃子，小形晶子，荒川高光，三木明徳．褥瘡様皮膚病変を誘発する動物実験モデルの開発−坐骨神経
切断後のラット踵部の形態学的観察−．神戸大学大学院保健学研究科 紀要 27: 31-41, 2012.
Fujiwara Y, Arakawa T, Fujita N, Fujino H, Miki A. Influence of magnetic stimulation on muscle atrophy in the rat
unloading hindlimb muscles. Bulletin of Health Sciences Kobe 27: 19-26, 2012.
Cancer Gene Ther. (19 (2) pp.144-52)2012 Feb E10A, an adenovirus-carrying endostatin gene, dramatically
increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse
model for head and neck squamous-cell carcinoma.Adhim Z, Lin X, Huang W, Morishita N, Nakamura T, Yasui H,
Otsuki N, Shigemura K, Fujisawa M, Nibu K, Shirakawa T.
Br J Cancer (105 (3) pp.393-402) 2011 Jul In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and
epithelial-to-mesenchymal transition in human bladder cancer cell lines. Adhim Z, Matsuoka T, Bito T, Shigemura
K, Lee KM, Kawabata M, Fujisawa M, Nibu K, Shirakawa T.
Kobayashi T, Ito T, Shiomi M,2011,Roles of the WHHL rabbit in translational research on hypercholesterolemia
and cardiovascular diseasesJ Biomed Biotechnol,2011 巻 1 号, 406473-406473
Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y,
Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J,2011,PDK1-Foxo1 in
agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy
expenditurePLoS One,6 巻 4 号,18324-18324
Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, Matsumoto T, Suehiro S, Carmeliet P, Asahara
T,2011,PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of
myo-angiogenic competent marrow progenitorsPLoS One,6 巻 9 号,24872-24872
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T,
Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y,2011,Ablation of
TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1PLoS
One,6 巻 8 号,23238-23238
Nagano T, Kotani Y, Kobayashi K, Hatakeyama Y, Hori S, Kasai D, Funada Y, Nishimura H, Kondoh T, Nishimura
Y,2011,Long-term outcome after multidisciplinary approach for leptomeningeal carcinomatosis in a non-small cell
lung cancer patient with poor performance statusIntern Med,50 巻 24 号,3019-3022
Yoshino H, Okumachi Y, Akisaki T, Yasuda H, Hara K, Yokono K, Akita H,2011,Bleeding from the small intestine
and aortic regurgitation in Noonan syndromeIntern Med,50 巻 21 号,2611-2613
Bouike G, Nishitani Y, Shiomi H, Yoshida M, Azuma T, Hashimoto T, Kanazawa K, Mizuno M,2011,Oral
Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and
Suppressed OVA-Sensitized Allergy in MiceEvid Based Complement Alternat Med,2011 巻. pii 号,532180-532180
Fujita N, Matsushita T, Ishida K, Sasaki K, Kubo S, Matsumoto T, Kurosaka M, Tabata Y, Kuroda R2011.6,An
analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein 2
from a biodegradable sponge composed of gelatin and β-tricalcium phosphateJ Tissue Eng Regen Med
Hayashi S, Nishiyama T, Miura Y, Fujishiro T, Kanzaki N, Hashimoto S, Matsumoto T, Kurosaka M, Kuroda
R,2011.7,DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritisOsteoarthritis
Cartilage,19 巻 7 号,903-910
Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y,
Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T,2011.7,Helicobacter suis KB1 derived from pig gastric
lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and
CD4 positive cellsMicrobes Infect,13 巻 7 号,697-708
Sugimoto M, Tanaka K, Matsuoka Y, Man-i M, Morita Y, Tanaka S, Fujiwara S, Azuma T,2011.7,da Vinci robotic
single-incision cholecystectomy and hepatectomy using single-channel GelPort accessJ Hepatobiliary Pancreat
Sci,18 巻 4 号,493-498
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Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M,2011.7,The effectiveness of particle radiotherapy for
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2014 年 2 月 J Immunol 192・4 1512-24
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2014 年 2 月 Exp Eye Res 119 61-9
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2014 年 3 月 J Orthop Res 32・3 455-63
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2014 年 3 月 Mucosal Immunol
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2014 年 3 月 J Vasc Interv Radiol 25・3 469-76
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2014 年 4 月 Am J Hypertens 27・4 586-95
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2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1321
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【サルコペニアとアンチエイジング】 筋肉研究の最前線 筋ジストロフィー
2013 年 8 月 アンチ・エイジング医学 9・4 号 541-547
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2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1322
松下 雄彦, 黒田 良祐, 松崎 時夫, 高山 孝治, 石田 一成, 佐々木 宏, 松本 知之, 藤田 周史, 長井 寛
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2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1520
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マウス変形性関節症モデルにおける徐放化 rapamycin 投与の関節症進行抑制効果
2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1605
上藤 淳郎, 松本 知之, 松下 雄彦, 川上 洋平, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, 黒田 良
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2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1508
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2013 年 8 月 日本整形外科学会雑誌 87・8 号 S1359
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2013 年 9 月 医学のあゆみ 246・10 号 893-901
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心臓と他臓器のコミュニケーションを探る 臓器関連から考える新しい循環器病治療戦略
管病予防の新たな治療ターゲットになる
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Therapeutic Superiority for Cartilage Repair by CD271 Positive Marrow Stromal Cell Transplantation
2013 年 Cell Transplant 22・7 1201-11
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2013 年 Nat Med 20・1 123-126
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2013 年 Circ J 77・6 1482-9
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2013 年 PLoS One 8・1 e54300
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2013 年 J Pain Res 6 87-94
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2013 年 Nat Commun 4 2436
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2013 年 Biomed Res Int 2013 109580
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2013 年 6 月 Mol Immunol 54・2 199-207
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2013 年 6 月 Eur J Cardiothorac Surg 43・6 1202-8
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2013 年 6 月 Invest Ophthalmol Vis Sci 54・6 4102-8
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2013 年 7 月 Neurotherapeutics 10・3 440-6
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A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization
2013 年 9 月 Lab Invest 93・9 1036-53
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Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of
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2013 年 9 月 PLoS One 8・9 e74864
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Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's
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2013 年 10 月 Biochem Biophys Res Commun 440・1 25-30
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GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine
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2013 年 10 月 Biochem Biophys Res Commun 440・1 88-93
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Efficacy of hemostasis for epidural venous plexus and safety for neural structure using soft coagulation system in
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2013 年 10 月 J Spinal Disord Tech 26・7 E281-5
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GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors
2013 年 10 月 J Neurosci 33・41 16372-82
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IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in
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2013 年 10 月 PLoS One 8・10 e76159
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2013 年 10 月 Proc Natl Acad Sci U S A 110・43 17474-9
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2013 年 10 月 Microbiol Immunol 57・10 704-14
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2013 年 10 月 Clin Cancer Res 19・20 5722-32
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Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired
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2013 年 10 月 J Biol Chem 288・41 29333-44
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Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity
2013 年 10 月 Cell Metab 18・4 491-504
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mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of
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2013 年 11 月 Cell Metab 18・5 726-39
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2013 年 11 月 Surg Endosc 27・11 4241-9
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AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan
2013 年 11 月 Sci Rep 3 3288
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2013 年 12 月 Diabetes 62・12 4165-73
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Chitosan Nanoparticle Encapsulated Hemagglutinin-Split Influenza Virus Mucosal Vaccine
2013 年 12 月 AAPS PharmSciTech
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2013 年 12 月 Parasitol Res 112・12 4009-13
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Varicella-zoster virus ORF49 functions in the efficient production of progeny virus through its interaction with
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2014 年 1 月 J Virol 88・1 188-201
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2014 年 1 月 Methods 65・2 254-9
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2014 年 1 月 Cancer Cell 25・1 102-17
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2014 年 2 月 Virology 450-451 98-105
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2014 年 2 月 Antioxid Redox Signal
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R-α lipoic acid γ-cyclodextrin complex increases energy expenditure: a 4-month feeding study in mice
2014 年 2 月 Nutrition 30・2 228-33
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Evaluation of chimeric DNA vaccines consisting of premembrane and envelope genes of Japanese encephalitis and
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2014 年 2 月 Microbiol Immunol 58・2 126-34
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2014 年 3 月 Rheumatology (Oxford)
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Michiko Aoyama-Ishikawa, Ayumi Seishu, Saori Kawakami, Noriaki Maeshige, Makoto Miyoshi, Takahiro Ueda,
Makoto Usami, Atsunori Nakao, Joji Kotani.
Intravenous immunoglovulin-induced neutrophil apoptosis in the lung during murine endotoxemia
2014 年 2 月 Surgical Infections 15(1):36-42.
Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.
2014 PLoS One 9(2):e89763. doi
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Low-intensity running exercise enhances the capillary volume and pro-angiogenic factors in the soleus muscle of
type 2 diabetic rats
in press Muscle & Nerve. in press
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Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb unloaded rats by astaxanthin
supplementation and intermittent loading
in press Experimental Physiology. in press
田中 稔，藤田 直人，藤野 英己．
下腿深層筋の筋萎縮に対する遠心性収縮を伴う中周波電気刺激による併用効果．
in press 日本物理療法学会会誌，in press
Kanazawa Y, Maekawa K, Okumura Y, Fujita N, Fujino H.
Preventive effect of nucleoprotein on hindlimb unloading-induced capillary regression in rat soleus muscle
2014 年 4 月 Biotechnic & histochemistry. 2014; 89(3): 220-227
Sjatha, F., Kuwahara, M., Sudiro, T. M., Kameoka, M. and Konishi, E.
Evaluation of chimeric DNA vaccines consisting of premembrane and envelope genes of Japanese encephalitis and
dengue viruses as a strategy for reducing induction of dengue virus infection-enhancing antibody response
2014 年 1 月 Microbiol. Immunol. 58 (2), 126-134, 2014
Murakami S, Ajiki T, Hori Y, Okazaki T, Fukumoto T, Ku Y. Establishment of a novel cell line from intraductal
papillary neoplasm of the bile duct. Anticancer Res 34: 2203-2210 (2014)
Shimizu K, Chiba S, Hori Y. Identification of a novel subpopulation of tumor-initiating cells from
gemcitabine-resistant pancreatic ductal adenocarcinoma patients. PLoS One e81283 (2013)
Hori Y. Prominin-1 (CD133) reveals new faces of pancreatic progenitor cells and cancer stem cells: current
knowledge and therapeutic perspectives. Adv Exp Med Biol 777: 185-196 (2013).
Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A,
García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y.
Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes in press,
2014.
Yoshida Y, Fuchita M, Kimura-Koyanagi M, Kanno A, Matsuda T, Asahara S, Hashimoto N, Isagawa T, Ogawa W,
Aburatani H, Noda T, Seino S, Kasuga M, Kido Y.
Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in
a low birth weight mouse model.
2014 年 5 月 Diabetology International. 5:43-52, 2014.
Takei S, Omoto C, Kitagawa K, Morishita N, Katayama T, Shigemura K, Fujisawa M, Kawabata M, Hotta H,
Shirakawa T. (2014)
Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein
could induce an HCV-NS3-specific systemic immune response in mice. Vaccine. 32(25):3066-74
Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound
healing.
Sakamoto Y, Okumura N, Koizumi N, Numata R, Kitano J, Yamamoto M, Komada T, Hoshi N.
Anim Eye Res, 32: 15-21, 2013.
Ferrets as a new experimental animal model for corneal endothelial research.
Sakamoto Y, Okumura N, Koizumi N, Yamasaki K, Kitano J, Numata R, Komada T, Hoshi N.
Anim Eye Res, 31: 3-11, 2013.
Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP)
expressions in the testes of mice during fetal development.
Warita K, Mitsuhashi T, Fukui S, Ohta K, Suzuki S, Miki T, Takeuchi Y, Yokoyama T, Kitagawa H, Sugawara T,
Hoshi N.
Reprod Biol, 13: 92-95, 2013.
Study on the ejaculate characteristics and liquid storage of semen in the common bottlenose dolphin (Tursiops
truncatus).
Takenaka A, Kashiwagi N, Maezono Y, Nakao T, Uwano Y, Kakizoe Y, Kinoshita K, Kusunoki H, Hoshi N.
Jpn J Zoo Wildlife Med, 18: 107-114, 2013.
Histochemical study on the relationship between invasion of indigenous bacteria into intestinal crypts and
proliferation of epithelial cells in rat ascending colon.
Mantani Y, Takahara E, Takeuchi T, Kawano J, Yokoyama T, Hoshi N, Kitagawa H.
J Vet Med Sci, 75: 939-947, 2013
Effects of exposure to clothianidin on the reproductive system of male quails.
Tokumoto J, Danjo M, Kobayashi Y, Kinoshita K, Omotehara T, Tatsumi A, Hashiguchi M, Sekijima T,
Kamisoyama H, Yokoyama T, Kitagawa H, Hoshi N.
J Vet Med Sci, 75: 755-760, 2013.
Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower
doses of bisphenol A in embryonic hypothalamic cells.
Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y.
J Toxicol Sci, 38: 285-289, 2013.
In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic
factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment.
Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y.
Congenit Anom, 53: 42-45, 2013.
Downregulation of cytochrome P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on
testicular steroidogenesis.
Maeda N, Okumura K, Tanaka E, Suzuki T, Miyasho T, Haeno S, Ueda H, Hoshi N, Yokota H.
Environ Toxicol, 2013 Jul 20. doi: 10.1002/tox.21875. [Epub ahead of print]
Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor- responsive element
III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain.
Tanida T, Tasaka K, Akahoshi E, Ishihara-Sugano M, Saito M, Kawata S, Danjo M, Tokumoto J, Mantani Y,
Nagahara D, Tabuchi Y, Yokoyama T, Kitagawa H, Kawata M, Hoshi N.
J Appl Toxicol, 34: 117-126, 2014. 2013 Jan 8. [Epub ahead of print]
Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by subepithelial blood
capillaries in rat jejunal villi.
Takahara E, Mantani Y, Udayanga KG, Qi WM, Tanida T, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H.
J Vet Med Sci, 2013, 75: 1563-1569. Epub 2013 Jul 26.
Peculiar Composition of Epithelial Cells in Follicle-Associated Intestinal Crypts of Peyer's Patches in the Rat Small
Intestine.
Mantani Y, Yuasa H, Nishida M, Takahara EI, Omotehara T, Udayanga KG, Kawano J, Yokoyama T, Hoshi N,
Kitagawa H.
J Vet Med Sci, 2014 Feb 27. [Epub ahead of print].
Spatiotemporal expression patterns of doublesex and mab-3 related transcription factor 1 in the chicken developing
gonads and Müllerian ducts.
Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y,
Yokoyama T, Kitagawa H, Hoshi N.
Poult Sci, 2014 doi: 10.3382/ps.2013-03672.
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stress in oral epithelial cells.
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2014. 4 J Biomed Sci. 7;21(1):28.
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induction ability of DGKb
2014. 3 Biochem. Biophys. Res. Comm. 447, 89-94
Sakuma M, Shirai Y, Ueyama T, Saito N.
Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca(2+) influxes.
2014.3 Biochem. Biophys. Res. Comm. 445, 340-345
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The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos
2014. 3 BMC Developemental Biology 13:35.
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Sakane, F., and Ishikawa, T
Depression of type I diacylglycerol kinases in pancreatic -cells from male mice results in impaired insulin
secretion.
2013.9 Endocrinology 154:4089-4098.
白井 康仁
DGKb は記憶及び感情障害改善薬のターゲットになりえるか？
2014.3 日薬理誌 143:131-136.
Ibuki M, Yoshimoto Y, Inui M, Fukui K, Yonemoto H, Saneyasu T, Honda K, Kamisoyama H, Investigation of the
growth-promoting effect of dietary nannanase-hydrolysed copra meal in growing broiler chickens, 2014 年 5 月,
Animal Science Journal, 85, 5, 562-568.
Honda K, Saneyasu T, Yamaguchi T, Shimatani T, Aoki K, Nakanishi K, Kamisoyama H, Intracerebroventricular
administration of chicken oxyntomodulin suppresses food intake and increases plasma glucose and corticosterone
concentrations in chicks, 2014 年 2 月, Neuroscience Letters, 564, 3, 57-61.
Honda K, Saneyasu T, Yamaguchi T, Shimatani T, Aoki K, Nakanishi K,amisoyama H, Intracerebroventricular
administration of novel glucagon-like peptide suppresses food intake in chicks, 2014 年 2 月, Peptides, 52, 98-103.
Saneyasu T, Nakanishi K, Atsuta H, Ikura A, Hasegawa S, Kamisoyama H, Honda K, Age-dependent changes in
the mRNA levels of neuropeptide Y, proopiomelanocortin, and corticotropin-releasing factor in the hypothalamus in
growing broiler chicks, 2013 年 10 月, The Journal of Poultry Science, 50, 4, 364-369.
Saneyasu T, Shiragaki M, Kurachi K, Kamisoyama H, Honda K, Effects of short-term refeeding on the expression
of genes involved in lipid metabolism in chicks (Gallus gallus), 2013 年 9 月, Comparative Biochemistry and
Physiology Part B: Biochemistry and Molecular Biology, 166, 1, 1-6.
Honda K, Saneyasu T, Motoki T, Park Y, Kamisoyama H, Dietary coenzyme Q10 suppresses hepatic
hydroxymethylglutaryl-CoA reductase activity in laying hens, 2013 年 7 月, Bioscience, Biotechnology, and
Biochemistry, 77, 7, 1572-1574.
Honda K, Saneyasu T, Hasegawa S, Tominaga Y, Yokota S, Kamisoyama H, Effect of licorice flavonoid oil on
cholesterol metabolism in diet-induced obese rats, 2013 年 6 月, Bioscience, Biotechnology, and Biochemistry, 77, 6,
1326-1328.
Saneyasu T, Shiragaki M, Nakanishi K, Kamisoyama H, Honda K, Effects of short term fasting on the expression
of genes involved in lipid metabolism in chicks, 2013 年 6 月, Comparative Biochemistry and Physiology Part B:
Biochemistry and Molecular Biology, 165, 2, 114-118.
Hiroshi Harayama
2013 年 10 月 Roles of intracellular cyclic AMP signal transduction in thecapacitation and subsequent
hyperactivation of mouse and boar spermatozoa J Reprod Dev. 2013 59(5):421-430.
Jibak Lee
Roles of cohesin and condensin in chromosome dynamics during mammalian meiosis
2013 年 10 月 J Reprod Dev 59: 431-436.
Yoko Yamashita, Masaru Yamaoka, Tomohisa Hasunuma, Hitoshi Ashida and Ken-ichi Yoshida
Detection of orally administered inositol stereoisomers in mouse blood plasma and their effects on translocation of
glucose transporter 4 in skeletal muscle cells.
2013 Journal of Agricultural and Food Chemistry. 61 (20), 4850-4854, 2013.
Yoko Yamashita, Masaaki Okabe, Midori Natsume, Hitoshi Ashida
Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 activity and insulin secretion
2013 Bioscience, Biotechnology and Biochemistry, 77, 888-891, 2013.
Masaya Kawase, Tadashi Saito, Yukihiro Nakano, Sayuri Imada, Yoko Yamashita and Hitoshi Ashida
Effect of green tea extract on mineral contents in mice hair.
2013 Food Science and Technology Research. 19, 123-125, 2013.
Tianshun Zhang, Songyan Jiang, Chao He, Yuki Kimura, Yoko Yamashita and Hitoshi Ashida
Black soybean seed coat polyphenols prevent B(a)P-induced DNA damage through modulating drug-metabolizing
enzymes in HepG2 cells and ICR mice.
2013 Mutation Research 752, 34-41, 2013.
Mantani, Y., Nishida, M., Yuasa, H., Yamamoto, K., Takahara, E., Omotehara, T., Udayanga, K. G. S., Kawano, J.,
Yokoyama, T., Hoshi, N., Kitagawa, H.
2014 年, in press, DOI 10.1002/ar.22937 Ultrastructural and histochemical study on the Paneth cells in the rat
ascending colon. The Anatomocal Record
Mantani, Y., Yuasa, H., Nishida, M., Takahara, E., Omotehara, T., Udayanga, K. G. S., Kawano, J., Yokoyama, T.,
Hoshi, N., Kitagawa, H.
2014 年 6 月 3 日 Peculiar composition of epithelial cells in follicle-associated intestinal crypts of Peyer’s patches
in the rat small intestine. The Journal of Veterinary Medical Science, 76 (6) 833-838.
Mantani, Y., Takahara, E., Takeuchi, T., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
2013 年 7 月 Histoplanimetrical study on the relationship between invasion of indigenous bacteria into intestinal
crypts and proliferation of epithelial cells in rat ascending colon. The Journal of Veterinary Medical Science, 75
(7) 939-947.
Takahara, E., Mantani, Y., Udayanga, K. G. S., Qi, W.-M., Tanida, T., Takeuchi, T., Yokoyama, T., Hoshi, N.,
Kitagawa, H.
2013 年 12 月 Ultrastructural demonstration of the absorption and transportation of minute chylomicrons by
subepithelial blood capillaries in rat jejunal villi.
The Journal of Veterinary Medical Science, 75 (12) 1563-1569.
Tokmakov, A. A., Hashimoto, T., Hasegawa, Y., Iguchi, S., Iwasaki, T., Fukami, Y. (2014) Monitoring gene
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Mahbub Hasan, AKM., Hashimoto, A., Maekawa, Y., Matsumoto, T., Kushima,S., Ijiri, T.W., Fukami,Y., and Sato,
K.-I. (2014) Oocyte membrane microdomains-associated uroplakin III-Src system becomes functional during
oocyte maturation and is required for bidirectional gamete signaling at fertilization in the frog Xenopus laevis.
Development 141(8), 1705-1714.
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H,
Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
2014 年 5 月 J. of Cell Science, 127, 2040-2052
Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Hiramatsu N, Matsuda T, Toda T, Saito N
The role of βPIX phosphorylation at Serines 340 and 583 by PKCγ in the dopamine release
2014 in press J. of Neuroscience, 2014 in press
理学療法から診る廃用症候群－基礎・予防・介入
脊髄損傷の廃用症候群
文光堂 平成２６年５月 森山英樹
Roles of nectins and nectin-like molecules in the nervous system. In Cell adhesion molecules: implications in
neurological diseases, Advances in Neurobiology (Berezin, V. and Walmond, P.S., eds.)
Springer, 2014 8:91-116. Mori, M., Rikitake, Y., Mandai, K., and Takai , Y.
次世代がん戦略研究 Update がん基盤生物学 革新的シーズ育成に向けて/がん微小環境を制御する
Ras/Rap 標的タンパク質 PLCε の選択的阻害剤の開発
南山堂 2013 年 10 月 枝松裕紀, 片岡徹 分担執筆 p142-p146
ワクチン開発における最新動向/経口ワクチン
株式会社情報機構 2013 年 10 月 白川利朗 分担執筆
p187-p196
The Enzymes, Vol. 34, Inhibitors of the Ras superfamily G-proteins, Part B/Discovery of Small-Molecule Ras
Inhibitors that Display Antitumor Activity by Interfering with Ras·GTP–Effector Interaction
Elsevier Inc. 2013 年 12 月 Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto, Tohru Kataoka 分担執筆
p1-p23
医学のあゆみ/光老化の臨床とメカニズム
医歯薬出版株式会社 2014 年 2 月 国定充
共同編集
p597-p601
厚生労働科学研究費補助金 難治性疾患克服研究事業 プリオン病及び遅発性ウイルス感染症に関する
調査 平成 23-25 年度総合研究報告書/麻疹ウイルス変異株による亜急性硬化性全脳炎（SSPE）の発症機
序の解明と SSPE 治療に向けてのウイルス抑制戦略の確立
2014 年 3 月 堀田博 分担執筆
厚生労働科学研究費補助金 難治性疾患克服研究事業 プリオン病及び遅発性ウイルス感染症に関する
調査 平成 25 年度総括・分担研究報告書/SSPE ウイルスの神経病原性は F、H 及び M 遺伝子の変異によ
って規定される
2014 年 3 月 堀田博 分担執筆
星 信彦（2013）
：第 9 章 リンパ器官（担当：リンパ節），日本獣医解剖学会（編），獣医組織学 改訂第
6 版，学窓社，東京
染色体と細胞核のダイナミクス 平岡泰・原口徳子 編，第７章「コヒーシンとコンデンシン」
化学同人
2013 年 11 月 李智博，平野達也
星 信彦（2013）： 農薬による野鳥への影響．野鳥，779: 8-11.
星 信彦．鳥の生殖機能に悪影響 ネオニコチノイド系農薬［共同通信（2 月 14 日，東京新聞・神戸新聞
（2014 年 2 月 14 日朝刊））
，（朝日・読売・毎日・日経・産経・神戸 2/17 夕刊）に掲載）］
-H26 年度
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H,
Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
2014 年 J Cell Sci
Kawara F, Inoue J, Takenaka M, Hoshi N, Masuda A, Nishiumi S, Kutsumi H, Azuma T, Ohdaira T
The influences of pepsin concentrations and pH levels on the disinfective activity of ozone nanobubble water
against helicobacter pylori
2014 年 Digestion 90・1 10-7
Mori M, Rikitake Y, Mandai K, Takai Y
Roles of nectins and nectin-like molecules in the nervous system
2014 年 Adv Neurobiol 8 91-116
Ratnoglik SL, Jiang DP, Aoki C, Sudarmono P, Shoji I, Deng L, Hotta H
Induction of Cell-Mediated Immune Responses in Mice by DNA Vaccines That Express Hepatitis C Virus NS3
Mutants Lacking Serine Protease and NTPase/RNA Helicase Activities
2014 年 6 月 PLoS One 9・6 e98877
Sakakibara S, Ishida Y, Hashikawa K, Yamaoka T, Terashi H
Intima/medulla reconstruction and vascular contraction-relaxation recovery for acellular small diameter vessels
prepared by hyperosmotic electrolyte solution treatment
2014 年 6 月 J Artif Organs 17・2 169-77
Tokuda E, Itoh T, Hasegawa J, Ijuin T, Takeuchi Y, Irino Y, Fukumoto M, Takenawa T
Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in
human breast cancer
2014 年 6 月 Cancer Res 74・11 3054-66
Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M
Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and
during ageing in mice
2014 年 7 月 Ann Rheum Dis 73・7 1397-404
Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue
T, Sakai Y, Kurosaka M, Komori T
Transcutaneous carbon dioxide induces mitochondrial apoptosis and suppresses metastasis of oral squamous cell
carcinoma in vivo
2014 年 7 月 PLoS One 9・7
e100530
Mandai K, Reimert DV, Ginty DD
Linx mediates interaxonal interactions and formation of the internal capsule
2014 年 7 月 Neuron 83・1 93-103
Onishi Y, Akisue T, Kawamoto T, Ueha T, Hara H, Toda M, Harada R, Minoda M, Morishita M, Sasaki R, Nishida
K, Kuroda R, Kurosaka M
Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous
histiocytoma
2014 年 8 月 Int J Oncol 45・2 732-8
Terashima Y, Nishiumi S, Minami A, Kawano Y, Hoshi N, Azuma T, Yoshida M
Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis
2014 年 8 月 Arch Biochem Biophys 555-556 55-65
Kanagawa M, Lu Z, Ito C, Matsuda C, Miyake K, Toda T
Contribution of dysferlin deficiency to skeletal muscle pathology in asymptomatic and severe dystroglycanopathy
models generation of a new model for Fukuyama congenital muscular dystrophy
2014 年 9 月 PLoS One 9・9 e106721
Yunus J, Setsu T, Kikkawa S, Sakisaka T, Terashima T
Cytoarchitecture of the olfactory bulb in the laggard mutant mouse
2014 年 9 月 Neuroscience 275 259-71
Nagano T, Edamatsu H, Kobayashi K, Takenaka N, Yamamoto M, Sasaki N, Nishimura Y, Kataoka T
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a
mouse model of bronchial asthma
2014 年 9 月 PLoS One 9・9 e108373
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H,
Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A,
Fukusaki E, Rorsman P, Seino S
Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion
2014 年 10 月 CELL REP 9・2 661-73
Muto T, Kokubu T, Mifune Y, Inui A, Harada Y, Yoshifumi, Takase F, Kuroda R, Kurosaka M
Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell apoptosis are associated with
tendon degeneration or rupture after corticosteroid injection
2014 年 10 月 J Orthop Res 32・10 1297-304
Yogianti F, Kunisada M, Nakano E, Ono R, Sakumi K, Oka S, Nakabeppu Y, Nishigori C
Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis
2014 年 10 月 J Invest Dermatol 134・10 2610-9
Shimizu M, Yasuda H, Hara K, Takahashi K, Nagata M, Yokono K
The dual role of scavenger receptor class A in development of diabetes in autoimmune NOD mice
2014 年 10 月 PLoS One 9・10 e109531
Sakata R, Kokubu T, Mifune Y, Inui A, Nishimoto H, Fujioka H, Kuroda R, Kurosaka M
A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair
2014 年 11 月 Int Orthop 38・11 2413-20
Ishida Y, Sakakibara S, Terashi H, Hashikawa K, Yamaoka T
Development of a novel method for decellularizing a nerve graft using a hypertonic sodium chloride solution
2014 年 11 月 Int J Artif Organs 37・1-11 854-60
Kawabata A, Serada S, Naka T, Mori Y
Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells
2014 年 12 月 J Gen Virol 95・Pt 12 2769-77
Matsuzaki T, Matsushita T, Tabata Y, Saito T, Matsumoto T, Nagai K, Kuroda R, Kurosaka M
Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of
experimental osteoarthritis in a murine model
2014 年 12 月 Biomaterials 35・37 9904-11
Miki A, Kanamori A, Nakamura M, Matsumoto Y, Mizokami J, Negi A
The expression of syntaphilin is down-regulated in the optic nerve after axonal injury
2014 年 12 月 Exp Eye Res 129 38-47
Koga T, Niikura T, Lee SY, Okumachi E, Ueha T, Iwakura T, Sakai Y, Miwa M, Kuroda R, Kurosaka M
Topical cutaneous CO2 application by means of a novel hydrogel accelerates fracture repair in rats
2014 年 12 月 J Bone Joint Surg Am 96・24 2077-84
Harada Y, Kokubu T, Mifune Y, Inui A, Sakata R, Muto T, Takase F, Kurosaka M
Dose- and time-dependent effects of triamcinolone acetonide on human rotator cuff-derived cells
2014 年 12 月 Bone Joint Res 3・12 328-34
Nishimura K, Saegusa J, Matsuki F, Akashi K, Kageyama G, Morinobu A
Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice
2014 年 12 月 Arthritis Rheumatol
Goto S, Fujii H, Kono K, Nakai K, Awata R, Yonekura Y, Hirata M, Shinohara M, Nishi S, Fukagawa M
22-Oxacalcitriol attenuates bone loss in nonobese type 2 diabetes
2015 年 1 月 Bone 74C 153-159
Nakamachi Y, Ohnuma K, Uto K, Noguchi Y, Saegusa J, Kawano S
MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats
2015 年 1 月 Ann Rheum Dis
Fujita T, Yamashita D, Uehara N, Inokuchi G, Hasegawa S, Otsuki N, Nibu K
A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice
2015 年 1 月 PLoS One 10・1 e0117547
Tang H, Mahmoud NF, Mori Y
Maturation of human herpesvirus-6A glycoprotein O requires coexpression of gH and gL
2015 年 2 月 J Virol
Ohtsuka Y, Kanagawa M, Yu CC, Ito C, Chiyo T, Kobayashi K, Okada T, Takeda S, Toda T
Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression
2015 年 2 月 Sci Rep 5 8316
Matsushita K, Miyake H, Chiba K, Fujisawa M
Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in the rat testis
2015 年 2 月 Andrologie
Sonoshita M, Itatani Y, Kakizaki F, Sakimura K, Terashima T, Katsuyama Y, Sakai Y, Taketo MM
Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH-DAB1-ABL-RHOGEF
Protein TRIO
2015 年 2 月 Cancer Discov 5・2 198-211
Yang L, Yamamoto K, Nishiumi S, Nakamura M, Matsui H, Takahashi S, Dohi T, Okada T, Kakimoto K, Hoshi N,
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Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection
2015 年 3 月 Mucosal Immunol 8・2 279-95
Kanno A, Asahara S, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y
Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation
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2015 年 3 月 Biochem Biophys Res Commun 458・3 681-6
Chinzei N, Hayashi S, Hashimoto S, Kanzaki N, Iwasa K, Sakata S, Kihara S, Fujishiro T, Kuroda R, Kurosaka M
Cyclin‑dependent kinase inhibitor p21 does not impact embryonic endochondral ossification in mice
2015 年 3 月 Mol Med Rep 11・3 1601-8
Sakata S, Hayashi S, Fujishiro T, Kawakita K, Kanzaki N, Hashimoto S, Iwasa K, Chinzei N, Kihara S, Haneda M,
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Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid
2015 年 3 月 J Orthop Res 33・3 359-65
Kurakawa T, Kakutani K, Morita Y, Kato Y, Yurube T, Hirata H, Miyazaki S, Terashima Y, Maeno K, Takada T,
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Functional impact of integrin α5β1 on the homeostasis of intervertebral discs a study of mechanotransduction
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2015 年 3 月 Spine J 15・3 417-26
Nakano N, Matsumoto T, Takayama K, Matsushita T, Araki D, Uefuji A, Nagai K, Zhang S, Inokuchi T, Nishida K,
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Age-dependent healing potential of anterior cruciate ligament remnant-derived cells
2015 年 3 月 Am J Sports Med 43・3 700-8
Okumachi E, Lee SY, Niikura T, Iwakura T, Dogaki Y, Waki T, Takahara S, Ueha T, Sakai Y, Kuroda R, Kurosaka
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Comparative analysis of rat mesenchymal stem cells derived from slow and fast skeletal muscle in vitro
2015 年 3 月 Int Orthop 39・3 569-76
Washio K, Kotani T, Saito Y, Respatika D, Murata Y, Kaneko Y, Okazawa H, Ohnishi H, Fukunaga A, Nishigori C,
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Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs
2015 年 3 月 Genes Cells
Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T,
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Foxp3 Regulatory T Cells Play a Protective Role in Angiotensin II-Induced Aortic Aneurysm Formation in Mice
2015 年 4 月 Hypertension 65・4 889-95
Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y,
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Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
2015 年 4 月 J Clin Invest 125・4 1591-602
Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R,
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Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via
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2015 年 4 月 Mol Nutr Food Res 59・4 729-40
Kitamura Y, Murata Y, Park JH, Kotani T, Imada S, Saito Y, Okazawa H, Azuma T, Matozaki T
Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in
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2015 年 4 月 Genes Cells
島扶美, 熊坂崇, 松本篤幸, 吉川陽子, 山本雅貴, 片岡徹
ras がん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発
2014 年 日本放射光学会誌 放射光 27・1 3-9
山下 智也, 笠原 和之, 佐々木 直人, 平田 健一
腸内細菌と心血管病
2014 年 6 月 循環器内科 75・6 号 610-617
西海 信, 寺島 禎彦, 東 健, 吉田 優
メタボロミクスによる非アルコール性脂肪性肝炎に対する治療薬の探索
2014 年 9 月 JSBMS Letters 39・Suppl. 70
戸田 達史
医学と医療の最前線 筋ジストロフィー治療の新しい展開
2014 年 11 月 日本内科学会雑誌 103・11 号 2820-2828
西田 康太郎, 高田 徹, 前野 耕一郎, 角谷 賢一朗, 由留部 崇, 黒坂 昌弘
【椎間板と痛み】 椎間板変性の疼痛発生機序について
2015 年 1 月 脊椎脊髄ジャーナル 28・1 号 25-31
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Oral tacrolimus for megacolon in patients with severe ulcerative colitis
2014 年 Intern Med 53・16 1755-8
Imoto A, Ooi Y, Edogawa S, Ogura T, Masuda D, Mohamed M, Takii M, Umegaki E, Kawahara R, Ukimura A,
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Liver abscess caused by CTX-M-55-type extended-spectrum β-lactamase (ESBL)-producing Salmonella enteritidis
2014 年 Intern Med 53・15 1699-703
Yu Q, Liu Z, Waqar AB, Ning B, Yang X, Shiomi M, Graham MJ, Crooke RM, Liu E, Dong S, Fan J
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2014 年 Mediators Inflamm 2014 979132
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Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury
2014 年 Biosci Biotechnol Biochem 78 1221-1230
Li S, Liang J, Niimi M, Bilal Waqar A, Kang D, Koike T, Wang Y, Shiomi M, Fan J
Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits
2014 年 J Atheroscler Thromb 21・7 648-58
Murata Y, Kotani T, Ohnishi H, Matozaki T
The CD47-SIRPα signalling system its physiological roles and therapeutic application
2014 年 6 月 J Biochem 155・6 335-44
Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, Zanvit P, Jin W, Konkel JE, Chen W
In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial
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2014 年 6 月 Sci Transl Med 6・241 241ra78
Tomotsuka N, Kaku R, Obata N, Matsuoka Y, Kanzaki H, Taniguchi A, Muto N, Omiya H, Itano Y, Sato T,
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Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model
2014 年 7 月 J Pain Res 7 415-23
Kawano Y, Ersoy BA, Li Y, Nishiumi S, Yoshida M, Cohen DE
Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote
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2014 年 7 月 Mol Cell Biol 34・13 2396-408
Shirafuji T, Ueyama T, Yoshino K, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T,
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The role of Pak-interacting exchange factor-β phosphorylation at serines 340 and 583 by PKCγ in dopamine release
2014 年 7 月 J Neurosci 34・28 9268-80
Oshima N, Yamada Y, Nagayama S, Kawada K, Hasegawa S, Okabe H, Sakai Y, Aoi T
Induction of cancer stem cell properties in colon cancer cells by defined factors
2014 年 7 月 PLoS One 9・7 e101735
Saito F, Kanagawa M, Ikeda M, Hagiwara H, Masaki T, Ohkuma H, Katanosaka Y, Shimizu T, Sonoo M, Toda T,
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Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and
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2014 年 9 月 Hum Mol Genet 23・17 4543-58
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Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic
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2014 年 9 月 Endocrinology 155・9 3459-72
Shanks NF, Cais O, Maruo T, Savas JN, Zaika EI, Azumaya CM, Yates JR 3rd, Greger I, Nakagawa T
Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3
2014 年 9 月 J Neurosci 34・36 12104-20
Naito Y, Ikuta N, Nakata D, Terao K, Matsumoto K, Kajiwara N, Okano A, Yasui H, Yoshikawa Y
Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex
2014 年 9 月 J Clin Biochem Nutr 55・2 97-102
Sawaengsak C, Mori Y, Yamanishi K, Srimanote P, Chaicumpa W, Mitrevej A, Sinchaipanid N
Intranasal chitosan-DNA vaccines that protect across influenza virus subtypes
2014 年 10 月 Int J Pharm 473・1-2 113-25
Tanaka-Okamoto M, Itoh Y, Miyoshi J, Mizoguchi A, Mizutani K, Takai Y, Inoue M
Genetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal
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2014 年 10 月 PLoS One 9・10 e110549
Nakazawa G, Shinke T, Ijichi T, Matsumoto D, Otake H, Torii S, Hiranuma N, Ohsue T, Otsuka F, Shite J, Hirata K,
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Comparison of vascular response between durable and biodegradable polymer-based drug-eluting stents in a
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2014 年 10 月 EuroIntervention 10・6 717-23
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Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV,
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miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development
2014 年 10 月 Nat Commun 5 5214
Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Shiomi M, Ye T, Dong S, Fan J
Bisphenol A exposure enhances atherosclerosis in WHHL rabbits
2014 年 10 月 PLoS One 9・10 e110977
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The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function
2014 年 10 月 Nat New Biol 514・7520 98-101
Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW
Platelet secretion and hemostasis require syntaxin-binding protein STXBP5
2014 年 10 月 J Clin Invest 124・10 4517-28
Van Hung T, Emoto N, Vignon-Zellweger N, Nakayama K, Yagi K, Suzuki Y, Hirata K
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary
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2014 年 11 月 Life Sci 118・2 313-28
Qiao C, Wang CH, Zhao C, Lu P, Awano H, Xiao B, Li J, Yuan Z, Dai Y, Martin CB, Li J, Lu Q, Xiao X
Muscle and heart function restoration in a limb girdle muscular dystrophy 2I (LGMD2I) mouse model by systemic
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2014 年 11 月 Mol Ther 22・11 1890-9
Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar SS,
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miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling
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2014 年 11 月 ELIFE 3・. doi 10
Takenaka N, Yasuda N, Nihata Y, Hosooka T, Noguchi T, Aiba A, Satoh T
Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in
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2014 年 11 月 Cell Signal 26・11 2460-9
Akasaka H, Sasaki R, Miyawaki D, Mukumoto N, Sulaiman NS, Nagata M, Yamada S, Murakami M, Demizu Y,
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Preclinical evaluation of bioabsorbable polyglycolic acid spacer for particle therapy
2014 年 12 月 Int J Radiat Oncol Biol Phys 90・5 1177-85
Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand
BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez
G, Ambati BK, Hinton DR
IL-18 is not therapeutic for neovascular age-related macular degeneration
2014 年 12 月 Nat Med 20・12 1372-5
Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S,
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M, Kaneda A, Iwama A, Nomura F
Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model,
promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1
2014 年 12 月 Oncotarget
Fukuda I, Nishiumi S, Mukai R, Yoshida KI, Ashida H
Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation
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Takamatsu Y, Hagino Y, Sato A, Takahashi T, Nagasawa SY, Kubo Y, Mizuguchi M, Uhl GR, Sora I, Ikeda K
Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking
dopamine transporter
2015 年 Curr Mol Med 15・3 245-52
Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I
Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice
2015 年 Curr Mol Med 15・3 237-44
Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N,
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Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A
The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and
Shows Associations with Dependence-Like Behavior in Genomic Association Study
2015 年 Curr Mol Med 15・3 265-74
Kawakami Y, Ii M, Matsumoto T, Kuroda R, Kuroda T, Kwon SM, Kawamoto A, Akimaru H, Mifune Y, Shoji T,
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SDF-1/CXCR4 axis in Tie2-lineage cells including endothelial progenitor cells contributes to bone fracture healing
2015 年 1 月 J Bone Miner Res 30・1 95-105
Fang C, Ning B, Waqar AB, Niimi M, Li S, Satoh K, Shiomi M, Ye T, Dong S, Fan J
Bisphenol A exposure induces metabolic disorders and enhances atherosclerosis in hyperlipidemic rabbits
2015 年 1 月 J Appl Toxicol 9
Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto M, Matsuzaki Y, Kotani T, Murata Y, Hirai H, Matsuda
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Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice
2015 年 2 月 Mol Cell Biol
Kawakami K, Inoue T, Murano M, Narabayashi K, Nouda S, Ishida K, Abe Y, Nogami K, Hida N, Yamagami H,
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Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis
2015 年 2 月 World J Gastroenterol 21・6 1880-6
Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ
Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst
2015 年 2 月 J Biol Chem 290・7 3894-909
Liang J, Kang D, Wang Y, Yu Y, Fan J, Takashi E
Carbonate ion-enriched hot spring water promotes skin wound healing in nude rats
2015 年 2 月 PLoS One 10・2
Nukaya D, Minami K, Hoshikawa R, Yokoi N, Seino S
Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas
2015 年 2 月 Genes Cells
Boku S, Toda H, Nakagawa S, Kato A, Inoue T, Koyama T, Hiroi N, Kusumi I
Neonatal maternal separation alters the capacity of adult neural precursor cells to differentiate into neurons via
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2015 年 2 月 Biol Psychiatry 77・4 335-44
Cheng Y, Feng Y, Jansson L, Sato Y, Deguchi M, Kawamura K, Hsueh AJ
Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector
YAP
2015 年 2 月 FASEB J
Yasuda H, Mukai H
Turning off of GluN2B subunits and on of CICR in hippocampal LTD induction after developmental GluN2
subunit switch
2015 年 2 月 Hippocampus
Nakamoto H, Nakayama K, Emoto N, Kajiya F
The short-term effects of C-peptide on the early diabetes-related ultrastructural changes to the podocyte slit
diaphragm of glomeruli in rats
2015 年 2 月 Microcirculation 22・2 122-32
Fujiwara K, Inoue T, Yorifuji N, Iguchi M, Sakanaka T, Narabayashi K, Kakimoto K, Nouda S, Okada T, Ishida K,
Abe Y, Masuda D, Takeuchi T, Fukunishi S, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K
Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced
indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration
2015 年 3 月 J Clin Biochem Nutr 56・2 155-62
Sakanaka T, Inoue T, Yorifuji N, Iguchi M, Fujiwara K, Narabayashi K, Kakimoto K, Nouda S, Okada T, Kuramoto
T, Ishida K, Abe Y, Takeuchi T, Umegaki E, Akiba Y, Kaunitz JD, Higuchi K
The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in
mice
2015 年 3 月 J Gastroenterol Hepatol 30・Suppl 1 60-5
Mu Y, Jin S, Shen J, Sugano A, Takaoka Y, Qiang L, Imbimbo BP, Yamamura K, Li Z
CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding
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2015 年 3 月 FEBS Lett 589・7 849-56
Putri DH, Sudiro TM, Yunita R, Jaya UA, Dewi BE, Sjatha F, Konishi E, Hotta H, Sudarmono P
Immunogenicity of a candidate DNA vaccine based on the prM/E genes of a dengue type 2 virus Cosmopolitan
genotype
2015 年 3 月 Jpn J Infect Dis
Tanaka Y, Noda K, Isse K, Tobita K, Maniwa Y, Bhama JK, D'Cunha J, Bermudez CA, Luketich JD, Shigemura N
A Novel Dual Ex Vivo Lung Perfusion Technique Improves Immediate Outcomes in an Experimental Model of
Lung Transplantation
2015 年 3 月 Am J Transplant
Ko CY, Chu YY, Narumiya S, Chi JY, Furuyashiki T, Aoki T, Wang SM, Chang WC, Wang JM
The CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis
in Alzheimer's disease
2015 年 3 月 Neurobiol Aging 36・3 1356-68
Takahashi H, Shibasaki T, Park JH, Hidaka S, Takahashi T, Ono A, Song DK, Seino S
Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion
2015 年 4 月 Diabetes 64・4 1262-72
Kawano Y, Nishiumi S, Saito M, Yano Y, Azuma T, Yoshida M
Identification of Lipid Species Linked to the Progression of Non-alcoholic Fatty Liver Disease
2015 年 4 月 Curr Drug Targets
Moriya Y, Kasahara Y, Hall FS, Sakakibara Y, Uhl GR, Tomita H, Sora I
Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor
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2015 年 4 月 Psychopharmacology (Berl) 232・8 1471-82
Yamashita D, Sun GW, Cui Y, Mita S, Otsuki N, Kanzaki S, Nibu K, Ogawa K, Matsunaga T
Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing
loss
2015 年 5 月 J Neurosci Res 93・5 788-95
Piao YS, Hall FS, Moriya Y, Ito M, Ohara A, Kikura-Hanajiri R, Goda Y, Lesch KP, Murphy DL, Uhl GR, Sora I
Methylone-induced hyperthermia and lethal toxicity role of the dopamine and serotonin transporters
2015 年 6 月 Behav Pharmacol 26・4 345-52
岡田 卓也, 山口 雅人, Muradi Akhmadu, 片山 直人, 上嶋 英介, 小出 裕, 祖父江 慶太郎, 杉本 幸司
【NBCA 塞栓術の現状と病理組織学的影響】 NBCA 塞栓術の現状と病理組織学的影響 膵臓
2014 年 8 月 IVR Interventional Radiology 29・3 号 252-257
高橋 晴美, グプルジャン・ゲニ , 清野 進
糖尿病成因解明の最前線 インスリン分泌を増強するシグナルのインタープレイとその臨床的示唆
2015 年 1 月 実験医学 33・1 号 124-126
松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒
田 良祐
骨関節の再生医療の現状と展望 自家末梢血 CD34 陽性細胞を用いた骨・血管再生療法に関する第 I・II
相臨床試験
2015 年 1 月 日本整形外科学会雑誌 89・1 号 26-32
ワクチン開発における最新動向 / 経口ワクチン
株式会社情報機構
2014 年 10 月 白川利朗 分担執筆 p187-p196
疾患モデルの作製と利用−脂質代謝異常と関連疾患 / 血管内皮リパーゼ
エル・アイ・シー
2015 年 安田知行, 石田達郎 分担執筆 p450-p456
清水 まみ、安田 尚史、原 賢太、高橋 和眞、永田 正男、横野 浩一
The Dual Role of Scavenger Receptor Class A in Development of Diabetes in Autoimmune NOD Mice
2014.10 PLOS ONE 9(10) e109531
Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia
in mice.
Yamashita H, Aoyama-Ishikawa M, Takahara M, Yamauchi C, Inoue T, Miyoshi M, Maeshige N, Usami M, Nakao
A, Kotani J.
Surg Infect (Larchmt). 2015 年 2 月 16(1)90-6.
Miho Kanazashi, Masayuki Tanaka, Shinichiro Murakami, Hiroyo Kondo, Fumiko Nagatomo, Akihiko Ishihara,
Roland R. Roy, Hidemi Fujino
Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb-unloaded rats by astaxanthin
supplementation and intermittent loading
2014 年 8 月 Experimental Physiology
Minoru Tanaka, Yusuke Hirayama, Naoto Fujita, Hidemi Fujino.
Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of
rat.
2014 年 9 月 Acta Histochem. Sep;116(7)1192-8, 2014.
田中 稔，藤田 直人，藤野 英己．
「下腿深層筋の筋萎縮に対する遠心性収縮を伴う中周波電気刺激による併用効果」
2014 年 7 月 物理療法科学，vol.21，p25-31，2014．
Murakami S, Ajiki T, Hori Y, Okazaki T, Fukumoto T, Ku Y.
Establishment of a novel cell line from intraductal papillary neoplasm of the bile duct.
2014.9
Anticancer Res 34 2203-2210
Bartolomé A, Kimura-Koyanagi M, Asahara SI, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A,
García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Pancreatic β cell failure mediated by
mTORC1 hyperactivity and autophagic impairment. Diabetes. 2014 63 2996-3008
Kanno A, Asahara SI, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y. Compensatory
hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translateon in islets.
Biochem Biophys Res Commun．2015 458 681-686
Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S,
Oyadomari S, Ozaki M, Kasuga M, Inoue H. Gadd34 regulates liver regeneration in hepatic steatosis. Hepatology
2015 61 1343-1356
Cook JR, Langlet F, Kido Y, Accili D. On the pathogenesis of selective insulin resistance in isolated hepatocytes. J
Biol Chem. 2015 290 13972-13980
Hatade T, Takeuchi K, Fujita N, Arakawa T, Miki A. (2014) Effect of heat stress soon after muscle injury on the
expression of MyoD and myogenin during regeneration process. J Musculoskelet Neuronal Interact, 14(3) 325-333.
Matsumoto A, Fujita N, Arakawa T, Fujino H, Miki A (2014) Influence of electrical stimulation on calpain and
ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles. Acta histochemica, 116
936-942.
エンドトキシン血症時における精巣生殖細胞アポトーシスと内因性 IL-18 の役割．
医学図書出版．エンドトキシン・自然免疫研究 17．p.98-102. 2014 年 11 月 井上岳人、石川倫子、西野
哲、笹野真希、岡伸樹、山下勇人、鴨志田伸吾、中尾篤典、宇佐美眞、小谷穣治．
Roles of nectins and nectin-like molecules in the nervous system. In Cell adhesion molecules implications in
neurological diseases, Advances in Neurobiology (Berezin, V. and Walmond, P.S., eds.)
Springer, 891-116., 2014 Mori, M., Rikitake, Y., Mandai, K., and Takai , Y.
最新醫学 2015 3 月増刊 糖尿病と合併症（前編）[膵 β 細胞量の調節因子], 淺原俊一郎，木戸良明，
（羽田
勝計編）, 487-495, 2015
SU 薬, 木村真希, 松田友和, 木戸良明, 月刊糖尿病, 7 巻, 88-94, 2015
膵 β 細胞のインスリン抵抗性, 淺原俊一郎，木戸良明，Diabetes Frontier，26 巻，321-325，2015
Furube, E. Morita, M. Miyata, S.
Characterization of neural stem cells and their progeny in the sensory circumventricular organs of adult mouse
2015 in press
Kobayashi, Y., Ronan da Silva, Kumanogoh, H., Miyata, S., Sato, C., Kitajima, K., Nakamura, S., Morita, M.,
Hayashi, F., Maekawa, S.,
Ganglioside contained in the NAP-22 fraction prepared from the detergent-resistant membrane microdomain of rat
brain inhibits the phosphatase activity of calcineurin.
2015 in press
Shohei Maekawa*, Yuumi Kobayashi, Mitsuhiro Morita, Toshinobu Suzaki,
Tight binding of NAP-22 with acidic membrane lipids
2015 in press
鈴木貴弘、田野亜都里、森田健太、荻野千秋、近藤昭彦
担癌マウスへの Ti ナノ粒子投与による生体内分布
第 17 回化学工学会 徳島大学常三島キャンパス 2015.3.7 （学会・研究発表会等）
Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F,
Maekawa S
Ganglioside contained in the NAP-22 fraction prepared from the detergent-resistent membrane microdomain of rat
brain inhibits the phosphatase activity of calcineurin.
2015. 5 J. Neuroscience Research
MANTANI YOUHEI, ITO ERI, NISHIDA MIHO, YUASA HIDETO, MASUDA NATSUMI, QI WANG-MEI,
KAWANO JUNICHI, YOKOYAMA TOSHIFUMI, HOSHI NOBUHIKO, KITAGAWA HIROSHI
Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout
the rat intestine.
The Journal of Veterinary Medical Science (accepted)
TAKAHARA EI-ICHIROU, YUASA HIDETO, NISHIDA MIHO, MANTANI YOUHEI, UDAYANGA
KANKANAM GAMAGE SANATH, QI WANG-MEI, TAKEUCHI TAKASHI, YOKOYAMA TOSHIFUMI,
HOSHI NOBUHIKO, KITAGAWA HIROSHI
Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute
chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum.
The Journal of Veterinary Medical Science 77 (4) 387-393, 2015
MANTANI YOUHEI, NISHIDA MIHO, YUASA HIDETO, YAMAMOTO KYOUJI, TAKAHARA EI-ICHIROU,
OMOTEHARA TAKUYA, UDAYANGA KANKANAM GAMAGE SANATH, KAWANO JUNICHI,
YOKOYAMA TOSHIFUMI, HOSHI NOBUHIKO, KITAGAWA HIROSHI
Ultrastructural and histochemical study on the Paneth cells in the rat ascending colon.
The Anatomical Record 297, 1462-1471, 2014,
MANTANI YOUHEI, YUASA HIDETO, NISHIDA MIHO, TAKAHARA EI-ICHIROU, OMOTEHARA
TAKUYA, UDAYANGA K. G. S., KAWANO JUNICHI, YOKOYAMA TOSHIFUMI, HOSHI NOBUHIKO,
KITAGAWA HIROSHI
Peculiar composition of epithelial cells in follicle-associated intestinal crypts of Peyer’s patches in the rat small
intestine,
The Journal of Veterinary Medical Science 76 (6) 833-838, 2014,
Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells,
Ueyama, T., Sakaguchi, H., Nakamura, T., Goto, A., Morioka, S., Shimizu, A., Nakao, K., Hishikawa, Y., Ninoyu,
Y., Kassai, H., Suetsug, J., Koji, T., Fritzsch, B., Yonemura, S., Hisa, Y., Matsuda, M., Aiba, A., and Saito, N.
J. Cell Sci. 1272040-2052, 2014
Diacylglycerol kinase gamma regulates antigen-induced mast cell degranulation by mediating Ca2+ influxes.
Sakuma, M., Shirai, Y., Ueyama, T., and Saito, N.
Biochem. Biophys. Res. Commun. 445(2)340-5, 2014
Both the C1 domain and a basic amino acid cluster at C-terminus are important for neurite and branch induction
ability of DGK.
Takuya Kano, Takeshi Kouzuki, Satoru Mizuno, Shuji Ueda, Minoru Yamanoue, Fumio Sakane, Naoaki Saito and
Yasuhito Shirai,
Biochem. Biophys. Res. Commun, 44789-94, 2014
Diacylglycerol kinase as a possible therapeutic target for neuronal diseases.
Shirai, Y and Saito, N,
Journal of Biomedical Science, 2128-28, 2014
Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein
kinase C gamma that causes spinocerebellar ataxia type 14.
Yamamoto, K., Seki, T., Yamamoto, H., Adachi, N., Tanaka, S., Hide, I., Saito, N. and Sakai, N.
Frontiers in Physiology, 5216(1-10), 2014 doi 10.3389/fphys.2014
The role of Pak-Interacting Exchange Factor-β phosphorylation at Serines 340 and 583 by PKC in dopamine
release.
Shirafuji, T., Ueyama, T., Yoshino, K-I., Takahashi, H., Adachi, N., Ago, Y., Koda, K., Nashida, T., Hiramatsu, N.,
Matsuda, T., Toda, T., Sakai, N., and Saito, N.
J Neurosci. 34(28) 9268-9280, 2014
RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCa signaling pathway.
Maillard, L., Saito, N., Hlawaty, H., Friand, V., Suffee, N., Chmilewsky, F., Haddad, O., Laguillier, C., Guyot, E.,
Ueyama, T., Oudar, O., Sutton, A., Charnaux, N.
Biology Open 3(10)995-1004. 2014
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.
Takahashi, H., Adachi, N., Shirafuji, T., Danno, S., Ueyama, T., Vendruscolo, M., Shuvaev,A.N., Sugimoto, T.,
Seki, T., Hamada, D., Irie, K., Hirai, H., Sakai, N. and Saito, N.
Human Mol. Genetics. 24(2)525-39. 2015
The Extracellular A-loop of Dual Oxidases Affects the Specificity of Reactive Oxygen Species Release.
Ueyama T, Sakuma M, Ninoyu Y, Hamada T, Dupuy C, Geiszt M, Leto TL, Saito N.
J Biol Chem. 290(10)6495-6506.2015
Turning off of GluN2B subunits and turning on of CICR in hippocampal
LTD induction after developmental GluN2 subunit switch.
Yasuda H, Mukai H.
Hippocampus. 2015 Feb 27. doi 10.1002/hipo.22435. [Epub ahead of print]
Yasuda H, Mukai H.
Turning off of GluN2B subunits and turning on of CICR in hippocampal LTD induction after developmental GluN2
subunit switch.
2015/2/27 Hippocampus. (in press)
Kanemura,E.,Goto,T.,Tatsu,Y., Imaishi,H., Morigaki,K.
Parallel assay of inkjet-printed cytochrome P450
2014 Anal. Methods 2117-2124
Sawada, K., Yamashita, Y., Zhang, T., Nakagawa, K., and Ashida, H
Glabridin induces glucose uptake via the AMP-activated protein kinase pathways in muscle cells.
2014 Molecular and Cellular Endocrinology ,393,1-2,99-108
Yamashita, Y., Wang, L., Tanaka, Y., Zhang, T., and Ashida, H.
Fermented tea suppresses adiposity through the activation of AMPK and modulation of its downstream events.
2014 Food and Functions 5, 10, 2420-2429
Zhang, T., Yamashita, Y., Yasuda, M., Yamamoto, N., and Ashida, H
Ashitaba (Angelica keiskei) extract prevent adiposity in high-fat diet-fed C57BL/6 mice. Molecular Nutrition and
Food Research.
2015 Food and Function.（6,1,135-145）
Hayashi D, Ueda S, Yamanoue M, Saito N, Ashida H and Shirai Y. (2015) Epigallocatechin-3-gallate activates
diacylglycerol kinase alpha via a 67 kDa laminin receptor a possibility of galloylated catechins as functional food
to prevent and/or improve diabetic renal dysfunctions. J. Functional Food 15, 561-569/
*Shirai Y, Saito N. (2014) Diacylglycerol kinase as a possible therapeutic target for neuronal diseases. J Biomed Sci.
2014 Apr 7;21(1)28. [Epub ahead of print].
白井
康仁、脳におけるジアシルグリセロールキナーゼの機能、生化学、86、p518-522 (2014)
Kojima A, Matsushita Y, Ogura Y, Ishikawa S, Noda T, Murase T, Harayama H.
Roles of extracellular Ca2+ in the occurrence of full-type hyperactivation in boar ejaculated spermatozoa
pre-incubated to induce the cAMP-triggered events.
2015 年 3 月 Andrology 3(2) 321-331
Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T,
Kitagawa H. (2014) Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides.
Biol Pharm Bull, 37 1439-1443.
Tabuchi Y, Yunoki T, Hoshi N, Suzuki N, Kondo T. (2014) Genes and gene networks involved in sodium
fluoride-elicited apoptosis accompanying endoplasmic reticulum stress in oral epithelial cells. Int J Mol Sci, 15
8959-8978; doi10.3390/ijms15058959
Mantani Y, Yuasa H, Nishida M, Takahara E, Omotehara T, Udayanga KG, Kawano J, Yokoyama T, Hoshi N,
Kitagawa H. (2014) Peculiar composition of epithelial cells in follicle-associated intestinal cruypts of Peyer’s
patches in the rat small intestine. J Vet Med Sci, 76 833-838.
Mantani Y, Hishida M, Yuasa H, Yamamoto K, Takahara E, Omotehara T, Udayanga KG, Kawano J, Yokoyama T,
Hoshi N, Kitagawa T. (2014) Ultrastructural and histochemical study on the Paneth cells in the rat ascending colon.
Anat Rec, 297 1462-1471.
Hirano T, Kobayashi Y, Omotehara T, Tatsumi A, Hashimoto R, Umemura Y, Nagahara D, Mantani Y, Yokoyama T,
Kitagawa H, Hoshi N. (2014) Unpredictable chronic stress-induced reproductive suppression associated with the
decrease of kisspeptin immunoreactivity in male mice. J Vet Med Sci. 761201-1208.
Omotehara T, Smith CA, Mantani Y, Kobayashi Y, Tatsumi A, Nagahara D, Hashimoto R, Hirano T, Umemura Y,
Yokoyama T, Kitagawa H, Hoshi N. (2014) Spatiotemporal expression patterns of doublesex and mab-3 related
transcription factor 1 in the chicken developing gonads and Müllerian ducts. Poult Sci. 93 953-958.
Warita K, Mitsuhashi T, Hoshi N, Ohta K, Suzuki S, Takeuchi Y, Miki T. (2014) A unique pattern of bisphenol a
effects on nerve growth factor gene expression in embryonic mouse hypothalamic cell line N-44. Arh Hig Rada
Toksikol. 2014 Sep 29;65(3)293-9. doi 10.2478/10004-1254- 65-2014-2494.
Tabuchi Y, Wada S, Ikegame M, Kariya A, Furusawa Y, Hoshi N, Yunoki T, Suzuki N, Takasaki I, Kondo T, Suzuki
Y. (2014) Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats
harboring temperature-sensitive simian virus40 large T-antigen gene. Exp Anim. 63 31-44.
Takahara E, Yuasa H, Nishida M, Mantani Y, Udayanga KG, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa
H. (2015) Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation
of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. J Vet Med Sci. 77
387-393.
Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara
Y, Shinohara R, Furuyashiki T, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. (2015) The combined effect of
clothianidin and environmental stress on the behavioral and reproductive function in male mice. J Vet Med Sci.
2015 May 10. [Epub ahead of print]11.
Mantani Y, Ito E, Nishida M, Yuasa H, Masuda N, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. (2015)
Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout
the rat intestine. J Vet Med Sci. 2015 Apr 20. [Epub ahead of print]
Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai,
S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. (2015) Immunohistochemical Analysis of
2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity on the Developmental Dentate Gyrus and Hippocampal
Fimbria in Fetal Mice. J Vet Med Sci. 2015 June 21. [Epub ahead of print]
Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K,
Yanai, S, Msuda N, Yuasa H, Mantani Y, Matuo E, Yokoyama T, Kitagawa H, Hoshi N. (2015) Ontogenic and
morphological study of gonadal formation in genetically-modified sex reversal XYPOS mice. J Vet Med Sci, in
press.
Hoshi N, Handa Y, Nishi S, Yamada H, Kishida T, Sagawa T, Sakuragi N, Fujimoto S. (2014) Molecular
cytogenetic aspects of sex differentiation anomalies in the field of obstetrics and gynecology. In Singh, J.R. and
Gandhi, G. (Eds.). Perspectives in Human Genetics, India. in press
Saneyasu T, Kimura S, Inui M, Yoshimoto Y, Honda K, Kamisoyama H
Differences in the expression of genes involved in skeletal muscle between broiler and layer chicks during food
deprivation
2015 年 8 月 Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, 186, 36-42,
2015.
Honda K, Shimatani T, Aoki K, Yamaguchi T, Kondo M, Saneyasu T, Kamisoyama H
Glucagon-like peptide-2 functions as anorexigenic peptide not only in the central nervous system but also in the
peripheral circulation in broiler chicks
2015 年 7 月 The Journal of Poultry Science, 52, 3, 183-187, 2015.
Honda K, Saneyasu T, Aoki K, Shimatani T, Yamaguchi T, Kamisoyama H
Correlation analysis of hypothalamic mRNA levels of appetite regulatory neuropeptides and several metabolic
parameters in 28-day-old layer chickens
2015 年 5 月 Animal Science Journal, 86, 4, 517-522, 2015.
Honda K, Saneyasu T, Shimatani T, Aoki K, Yamaguchi T, Nakanishi K, Kamisoyama H
Intracerebroventricular administration of chicken glucagon-like peptide-2 potently suppresses food intake in chicks
2015 年 3 月 Animal Science Journal, 86, 3, 312-318, 2015.
Martin Houlard, Jonathan Godwin, Jean Metson, Jibak Lee, Tatsuya Hirano, Kim Nasmyth
Condensin confers the longitudinal rigidity of chromosomes
2015 年 5 月 (published online) Nature Cell Biology, advanced online publication,
http//dx.doi.org/10.1038/ncb3167
Maekawa S, Kobayashi Y, Morita M, Suzaki T
Tight binding of NAP-22 with acidic membrane lipids.
2015 年 7 月 Neurosci. Lett. 600: 244-248
Morita, M., Nakane, A., Maekawa, S, Kudo, Y.
Pharmacological characterization of the involvement of protein kinase C in oscillatory and non-oscillatory calcium
increases in astrocytes
2015 年 8 月 J Pharm Sci 129: 38-42
Morita, M., Nakane, A., Fujii, Y., Maekawa, S, Kudo, Y
High cell density upregulates calcium oscillation by increasing calcium store content via basal mitogen-activated
protein kinase activity
2015 年 9 月 PLoS ONE 10: e0137610
Zhang T, Yamashita Y, Yasuda M, Yamamoto N, Ashida H.
Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice.
2015 年 Food Funct. 6:135-145.
食品因子による栄養機能制御(第 12 章
建帛社
2015 年 山下陽子、芦田均
プロシアニジンによる血糖ならびに脂質代謝調節)
Lui K, Kunii N, Sakuma M, Yamaki A, Mizuno S, Sato M, Sakai H, Kado S, Kumagai K, Kojima H, Okabe T,
Nagano T, Shirai Y, Sakane F.
A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune
response.
2016 年 J. lipid Res. 57, 368-379.
Ueda S, Kokaji Y, Shimizu S, Honda K, Yoshino K, Kamisoyama H, Shirai Y,Yamanoue M.
Chicken heat shock protein HSPB1 increases and interacts withαB-crystallin in aged skeletal muscle.
2015 年 Bioscience Biotechnology and Biochemistry 79,1867-1875.
Isono A, Tate S, Nakamura-Mori K, Noda T, Ishikawa S, Harayama H.
Involvement of cAMP-dependent unique signaling cascades in the decrease of serine/threonine-phosphorylated
proteins in boar sperm head.
2016 年 4 月 Theriogenology. 85(6):1152-1160.
Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K,
Yanai, S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N.
Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XYPOS mice.
2016 年 J Vet Med Sci, 77: 1587-1598.
Hirano T, Yanai S, Omotehara T, Hashimoto R, Umemura Y, Kubota N, Minami K, Nagahara D, Matsuo E, Aihara
Y, Shinohara R, Furuyashiki T, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N
he combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male
mice. 2015 年 J Vet Med Sci. 77: 1207-1215.
Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai,
S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N.
Immunohistochemical Analysis of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Toxicity on the Developmental
Dentate Gyrus and Hippocampal Fimbria in Fetal Mice. 2015 年 J Vet Med Sci. 77: 1355-1361.
Mantani Y, Ito E, Nishida M, Yuasa H, Masuda N, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H.
Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout
the rat intestine. 2015 年 J Vet Med Sci. 77: 1121-1128.
Takahara E, Yuasa H, Nishida M, Mantani Y, Udayanga KG, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa
H. Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of
minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. 2015 年
J Vet Med Sci. 77: 387-393.
石庭寛子，十川和博，安元研一，星信彦，関島恒夫
ダイオキシン汚染がアカネズミ個体群に及ぼす影響: 遺伝子マーカーを用いて個体群の反応を捉える試
み．（特集１ 生態系における汚染の動態と影響） 2016 年 日本生態学会誌 66: 69-79.
Hoshi, N., Handa, Y., Nishi, S., Yamada, H., Kishida, T., Sagawa, T., Sakuragi, N. and Fujimoto, S.
Molecular cytogenetic aspects of sex differentiation anomalies in the field of obstetrics and gynecology.
J.R. and Gandhi, G. (Eds.). 2015 年 Perspectives in Human Genetics, India.
In: Singh,
Yuka Taninoi, Hashimoto Takashi, Takao Ojima, Masashi Mizuno
F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti -allergic activity
2016 年 5 月 Journal of Clinical Biochemistry and Nutrition
Honda K, Saneyasu T, Sugimoto H, Kurachi K, Takagi S, Kamisoyama H
Peroxisome proliferation-activated receptor alpha target genes are different between mammals and chickens
2016 年 1 月 Animal Science Journal, 87, 1, 61-66
Honda K, Saneyasu T, Okuda M, Uemura T, Kamisoyama H
Glucagon and neuromedin U suppress food intake in broiler chicks
2015 年 11 月 The Journal of Poultry Science, 52, 4, 268-278
Won-Young Song, Yoshiko Aihara, Takashi Hashimoto, Kazuki Kanazawa and Masashi Mizuno
(-)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones
2015 年 Journal of Clinical Biochemistry and Nutrition 57(2):164-169
Ringhofer M. & Yamamoto S.
Domestic horses communicate with humans on the basis of humans’ knowledge states
Mukai, H., Muramatsu, A., Mashud, R., Kubouchi, K., Tsujimoto, S., Hongu, T., Kanaho, Y., Tsubaki, M., Nishida,
S., Shioi, G., Danno, S., Mehruba, M., Satoh, R., and Sugiura, R.
2016 年 PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
Sci Rep 6, 18979
Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamaru, K., Yamagata, H.,
Imaishi, H.
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2015 年 Kobe J Med Sci 61・4 E115-E123
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Postnatal Development of the Corticospinal Tract in the Reeler Mouse
2015 年 Kobe J Med Sci 61・3 E71-E81
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Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in
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2015 年 Biomed Res Int 2015 273784
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Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi N, Inoue H, Ogawa W, Seino S, Kido Y
Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced
by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity
2015 年 6 月 PLoS One 10・6 e0130757
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Anti-oxidative Effect of the β-blocker Carvedilol on Diabetic Nephropathy in Non-obese Type 2 Diabetic Rats
2015 年 7 月 Clin Exp Pharmacol Physiol
Muto T, Kokubu T, Mifune Y, Inui A, Sakata R, Harada Y, Takase F, Ueda Y, Kuroda R, Kurosaka M
Can Platelet-Rich Plasma Protect Rat Achilles Tendons From the Deleterious Effects of Triamcinolone Acetonide
2015 年 7 月 Orthop J Sports Med 3・7 2325967115590960
Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T,
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Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y
Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c
2015 年 7 月 Proc Natl Acad Sci U S A 112・27 8332-7
Sasayama T, Tanaka K, Mizowaki T, Nagashima H, Nakamizo S, Tanaka H, Nishihara M, Mizukawa K, Hirose T,
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2015 年 8 月 Brain Pathol
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Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell
precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in
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2015 年 8 月 Cardiovasc Diabetol 14 104
Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Kuroda R, Kurosaka M
Profiling microRNA expression in fracture nonunions: Potential role of microRNAs in nonunion formation studied
in a rat model
2015 年 8 月 Bone Joint J 97-B・8 1144-51
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Current status of the development of Ras inhibitors
2015 年 8 月 J Biochem 158・2 91-9
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2015 年 8 月 Proc Natl Acad Sci U S A 112・31 E4264-71
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Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through
autophagy induction in human intervertebral disc nucleus pulposus cells
2015 年 9 月 Arthritis Res Ther 17 253
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STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system
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2015 年 9 月 J Neurooncol 124・2 165-74
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Targeting glutaminase and mTOR
2015 年 9 月 Oncotarget 6・29 26544-5
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Antitumor effect of YM155, a novel small-molecule survivin suppressant, via mitochondrial apoptosis in human
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2015 年 9 月 Int J Oncol 47・3 891-9
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Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum
2015 年 9 月 Neurosci Lett 604 42-6
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Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea
2015 年 10 月 Neurosci Lett 606 188-93
Ijuin T, Hosooka T, Takenawa T
Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal
Muscle to Insulin Resistance
2015 年 10 月 Mol Cell Biol 36・1 108-18
Kakuta S, Nishiumi S, Yoshida M, Fukusaki E, Bamba T
Profiling of volatile compounds in APC(Min/ ) mice blood by dynamic headspace extraction and gas
chromatography/mass spectrometry
2015 年 10 月 J Chromatogr B Analyt Technol Biomed Life Sci 1003 35-40
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Acceleration of Proteinuria without Significant Impact on Renal Function and Its Protection by Angiotensin II
Receptor Blocker in Rats Treated with Axitinib
2015 年 10 月 Target Oncol
Takeda H, Koike T, Izumi Y, Yamada T, Yoshida M, Shiomi M, Fukusaki E, Bamba T
Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits
2015 年 10 月 J Biosci Bioeng 120・4 476-82
Tanaka K, Sasayama T, Mizukawa K, Takata K, Sulaiman NS, Nishihara M, Kohta M, Sasaki R, Hirose T, Itoh T,
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Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade
glioma
2015 年 11 月 Clin Neurol Neurosurg 138 37-44
Hayashi S, Fujishiro T, Hashimoto S, Kanzaki N, Chinzei N, Kihara S, Takayama K, Matsumoto T, Nishida K,
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p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation
2015 年 11 月 Arthritis Res Ther 17 314
Enatsu N, Miyake H, Chiba K, Fujisawa M
Identification of Spermatogenically Active Regions in Rat Testes by Using Narrow-band Imaging System
2015 年 11 月 Urology 86・5 929-35
Murakami K, Matsuura M, Ota M, Gomi Y, Yamanishi K, Mori Y
A recombinant varicella vaccine harboring a respiratory syncytial virus gene induces humoral immunity
2015 年 11 月 Vaccine 33・45 6085-92
Fujii H, Nakai K, Yonekura Y, Kono K, Goto S, Hirata M, Shinohara M, Nishi S, Fukagawa M
The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus
2015 年 12 月 Cardiovasc Drugs Ther 29・6 499-507
Makoto Suzuki, Shin Nishiumi, Takashi Kobayashi, Takeshi Azuma, Masaru Yoshida
LC-MS/MS-based metabolome analysis detected changes in the metabolic profiles of small and large intestinal
adenomatous polyps in Apc Min/+ mice
2016 年 Metabolomics
Suehara T, Morishita J, Ueki M, Ueno M, Maekawa N, Mizobuchi S
Effects of sevoflurane exposure during late pregnancy on brain development of offspring mice
2016 年 1 月 Paediatr Anaesth 26・1 52-9
Ikeo N, Nakamura R, Naka K, Hashimoto T, Yoshida T, Urade T, Fukushima K, Yabuuchi H, Fukumoto T, Ku Y,
Mukai T
Fabrication of a magnesium alloy with excellent ductility for biodegradable clips
2016 年 1 月 Acta Biomater 29 468-76
Tian H, Fukunaga A, Yodoi J, Nishigori C
Aerosol Delivery Enhances Percutaneous Permeability of Epidermal Growth Factor and Thioredoxin
2016 年 1 月 J Clin Investig Dermatol 4・1
Mahmoud NF, Kawabata A, Tang H, Wakata A, Wang B, Serada S, Naka T, Mori Y
Human herpesvirus 6 U11 protein is critical for virus infection
2016 年 1 月 Virology 489 151-157
Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y
Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to
Psychiatric Disorders
2016 年 1 月 Cereb Cortex
Qi X, Okinaka Y, Nishita M, Minami Y
Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation
2016 年 2 月 Genes Cells
Iwata E, Hasegawa T, Takeda D, Ueha T, Kawamoto T, Akisue T, Sakai Y, Komori T
Transcutaneous carbon dioxide suppresses epithelial-mesenchymal transition in oral squamous cell carcinoma
2016 年 2 月 Int J Oncol
Waki T, Lee SY, Niikura T, Iwakura T, Dogaki Y, Okumachi E, Oe K, Kuroda R, Kurosaka M
Profiling microRNA expression during fracture healing
2016 年 2 月 BMC Musculoskelet Disord 17・1 83
Katsunuma S, Honda H, Shinoda T, Ishimoto Y, Miyata T, Kiyonari H, Abe T, Nibu K, Takai Y, Togashi H
Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium
2016 年 2 月 J Cell Biol 212・5 561-75
Ijuin T, Hatano N, Takenawa T
Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization
2016 年 3 月 Genes Cells
Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M,
Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T
Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy
2016 年 3 月 Cell Rep 14・9 2209-23
Eguchi N, Hishimoto A, Sora I, Mori M
Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus
2016 年 3 月 Neurosci Lett 616 170-6
蒲田 悦子, 河本 旭哉, 原 仁美, 大西 康央, 簑田 正也, 森下 雅之, 上羽 岳志, 黒坂 昌弘, 秋末 敏宏
骨肉腫細胞に対する Smac 模倣薬とアドリアマイシンの併用効果
2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1227
金森 章泰
【NMO 最前線】 モデル動物による視神経脊髄炎の研究
2015 年 6 月 神経眼科 32・2 号 142-147
古屋敷 智之
【プロスタグランジンによる病態制御の最前線】 ストレス関連行動における COX-1-PGE2-EP1 系の役割
2015 年 6 月 細胞 47・6 号 270-273
山下 智也, 佐々木 直人, 平田 健一
慢性炎症制御による動脈硬化予防
2015 年 6 月 Bio Clinica 4・2 50-55
森下 雅之, 河本 旭哉, 蓑田 正也, 大西 康央, 原 仁美, 上羽 岳志, 蒲田 悦子, 黒坂 昌弘, 秋末 敏宏
AICAR の骨肉腫細胞に対するアポトーシス誘導効果
2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1241
蓑田 正也, 河本 旭哉, 上羽 岳志, 原 仁美, 大西 康央, 森下 雅之, 蒲田 悦子, 黒坂 昌弘, 秋末 敏宏
Survivin 抑制薬"YM155"は骨肉腫細胞において腫瘍増殖を抑制する
2015 年 6 月 日本整形外科学会雑誌 89・6 号 S1238
古屋敷 智之
痛みと情動 ストレスによる情動変化と脳内の自然免疫系
2015 年 7 月 PAIN RESEARCH 30・2 号 70
蒲田 悦子, 河本 旭哉, 上羽 岳志, 原 仁美, 大西 康央, 簑田 正也, 森下 雅之, 黒坂 昌弘, 秋末 敏宏
骨肉腫細胞に対する Smac 模倣薬と抗癌剤の併用効果の検討
2015 年 9 月 日本整形外科学会雑誌 89・8 号 S1674
古屋敷 智之
【プロスタグランジンと炎症】 ストレスによる情動制御における PGE2-EP1 系の役割
2015 年 9 月
医学のあゆみ
254・12 号
1115-1120
森下 雅之, 河本 旭哉, 大西 康央, 蓑田 正也, 蒲田 悦子, 原 仁美, 上羽 岳志, 黒坂 昌弘, 秋末 敏宏
AICAR の骨肉腫細胞に対するアポトーシス誘導効果
2015 年 9 月 日本整形外科学会雑誌 89・8 号 S1802
西田 康太郎, 角谷 賢一朗, 前野 耕一郎, 高田 徹, 由留部 崇, 山本 潤哉, 平田 裕亮, 蔵川 拓外, 酒井
大輔, 持田 讓治, 舛田 浩一, 森田 有亮, 黒坂 昌弘
椎間板変性と臨床 未来への展望 椎間板変性の発生機序と臨床との関連について
2015 年 9 月 日本整形外科学会雑誌 89・9 号 579-584
北岡 志保, 古屋敷 智之
【脂質疾患学 なぜあぶらの異常が病気を引き起こすのか?その質的量的変化と肥満、がん、不妊症、免
疫・皮膚・神経疾患】 (第 2 章)多彩な疾患における脂質の量的・質的変化 神経疾患 ドパミン依存的
な情動行動における PGE2-EP1 経路の役割と精神疾患との関連
2015 年 9 月 実験医学 33・15 号 2468-2473
向山 順子, 下野 洋平, 船越 洋平, 河野 誠之, 山下 公大, 向原 徹, 高尾 信太郎, 南 博信, 掛地 吉弘
NK 細胞浸潤がヒト乳がん異種移植マウスの腫瘍増殖に与える影響
2015 年 10 月 癌と化学療法 42・10 号 1252-1255
江本 拓央, 山下 智也, 平田 健一
腸内細菌と循環器疾患
2015 年 10 月 臨床化学 44・4 282-289
淀井 景子, 山下 智也, 河野 浩之, 佐々木 直人, 北 智之, 笠原 和之, 佐々木 義浩, 松本 卓也, 江本
拓央, 溝口 泰司, 林 友鴻, 平田 健一
ンジオテンシン II 誘発性大動脈瘤形成に対する n-3 系多価不飽和脂肪酸 EPA と DHA の差異の検討
2015 年 10 月 薬理と治療 43・10 1409-1416
Fukuda I, Nishiumi S, Mukai R, Yoshida KI, Ashida H
Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation
pathway in rat livers
2015 年 Int J Food Sci Nutr
Takamatsu Y, Hagino Y, Sato A, Takahashi T, Nagasawa SY, Kubo Y, Mizuguchi M, Uhl GR, Sora I, Ikeda K
Improvement of learning and increase in dopamine level in the frontal cortex by methylphenidate in mice lacking
dopamine transporter
2015 年 Curr Mol Med 15・3 245-52
Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I
Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice
2015 年 Curr Mol Med 15・3 237-44
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The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and
Shows Associations with Dependence-Like Behavior in Genomic Association Study
2015 年 Curr Mol Med 15・3 265-74
Ueda S, Kokaji Y, Simizu S, Honda K, Yoshino K, Kamisoyama H, Shirai Y, Yamanoue M
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2015 年 Biosci Biotechnol Biochem 79・11 1867-75
Yokoi N, Beppu M, Yoshida E, Hoshikawa R, Hidaka S, Matsubara T, Shinohara M, Irino Y, Hatano N, Seino S
Identification of putative biomarkers for prediabetes by metabolome analysis of rat models of type 2 diabetes
2015 年 Metabolomics 11・5 1277-1286
Ohbuchi K, Nishiumi S, Fujitsuka N, Hattori T, Yamamoto M, Inui A, Azuma T, Yoshida M
Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma
2015 年 Evid Based Complement Alternat Med 2015 871832
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Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat
2015 年 J DIABETES RES 2015 261418
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Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats
2015 年 J OPHTHALMOL 2015 492050
Schloesser A, Esatbeyoglu T, Piegholdt S, Dose J, Ikuta N, Okamoto H, Ishida Y, Terao K, Matsugo S, Rimbach G
Dietary Tocotrienol/γ-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations
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2015 年 Oxid Med Cell Longev 2015 789710
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2015 年 6 月 Behav Pharmacol 26・4 345-52
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2015 年 6 月 PLoS One 10・6 e0128805
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Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice
2015 年 6 月 Transl Psychiatry 5 e577
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2015 年 6 月 Circulation 131・24 e531-2
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Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling
2015 年 6 月 PLoS One 10・6 e0127178
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2015 年 6 月 Sci Rep 5 10536
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2015 年 6 月 Neuromuscul Disord 25・6 474-84
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2015 年 7 月 Proc Natl Acad Sci U S A 112・30 9406-11
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2015 年 7 月
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2015 年 7 月 Am J Pathol 185・7 2025-37
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2015 年 7 月 PLoS One 10・7 e0134113
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2015 年 8 月 Reproduction 150・2 105-14
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Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 weeks in endotoxemic rats using
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2015 年 8 月 Clin Nutr 34・4 685-93
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2015 年 8 月 Nutr Metab (Lond) 12 30
Takayama K, Kawakami Y, Mifune Y, Matsumoto T, Tang Y, Cummins JH, Greco N, Kuroda R, Kurosaka M, Wang
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The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation
2015 年 8 月 Biomaterials 60 9-19
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Role for RalA downstream of Rac1 in skeletal muscle insulin signalling
2015 年 8 月 Biochem J 469・3 445-54
Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB
Novel role for retinol-binding protein 4 in the regulation of blood pressure
2015 年 8 月 FASEB J 29・8 3133-40
Inoue T, Fujiwara T, Rikitake Y, Maruo T, Mandai K, Kimura K, Kayahara T, Wang S, Itoh Y, Sai K, Mori M, Mori
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Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork
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2015 年 8 月 J Comp Neurol 523・12 1824-39
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Targeted activation of endothelin-1 exacerbates hypoxia-induced pulmonary hypertension
2015 年 9 月 Biochem Biophys Res Commun 465・3 356-62
Uchida R, Okamoto H, Ikuta N, Terao K, Hirota T
Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats
2015 年 9 月 Int J Mol Sci 16・9 22781-94
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Nectin-1 spots regulate the branching of olfactory mitral cell dendrites
2015 年 9 月
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Yamamoto H, Mandai K, Konno D, Maruo T, Matsuzaki F, Takai Y
Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic
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2015 年 9 月 Brain Res 1620 139-52
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Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis
2015 年 9 月 Nat Commun 6 8424
Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM,
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The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide
2015 年 9 月 Am J Respir Cell Mol Biol 53・3 314-25
Kaneko C, Nitta N, Tsuchiya K, Watanabe S, Nitta-Seko A, Ohta S, Otani H, Sonoda A, Murata K, Shiomi M
MRI study of atherosclerotic plaque progression using ultrasmall superparamagnetic iron oxide in Watanabe
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2015 年 9 月 Br J Radiol 88・1053 20150167
Naito Y, Ikuta N, Okano A, Okamoto H, Nakata D, Terao K, Matsumoto K, Kajiwara N, Yasui H, Yoshikawa Y
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2015 年 9 月 Life Sci 136 73-8
Fujiwara M, Miyoshi M, Sakai S, Nishiokada A, Aoyama-Ishikawa M, Maeshige N, Usami Y, Hamada Y,
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Lard-based high-fat diet increases secretory leukocyte protease inhibitor expression and attenuates the
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2015 年 10 月 Clin Nutr 34・5 997-1009
Sakti Muliawan H, Nakayama K, Yagi K, Ikeda K, Yagita K, Hirata K, Emoto N
Stable Somatic Gene Expression in Mouse Lungs Following Electroporation-mediated Tol2 Transposon Delivery
2015 年 10 月 Kobe J Med Sci 61・2 E47-53
Panza P, Sitko AA, Maischein HM, Koch I, Fl?tenmeyer M, Wright GJ, Mandai K, Mason CA, S?llner C
The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm
2015 年 10 月 Neural Dev 10 23
Zhang D, Tu E, Kasagi S, Zanvit P, Chen Q, Chen W
Manipulating regulatory T cells: a promising strategy to treat autoimmunity
2015 年 11 月 Immunotherapy 7・11 1201-11
Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M
The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression
2015 年 11 月 Mol Cell Biol 36・3 407-20
Ijuin T, Hatano N, Hosooka T, Takenawa T
Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum
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2015 年 12 月 Biochim Biophys Acta 1853・12 3192-201
Andoh T, Fujimoto T, Suzuki M, Sudo T, Sakurai Y, Tanaka H, Fujita I, Fukase N, Moritake H, Sugimoto T,
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Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a
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2015 年 12 月 Appl Radiat Isot 106 195-201
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2015 年 12 月 Appl Radiat Isot 106 220-5
Hara T, Ughi GJ, McCarthy JR, Erdem SS, Mauskapf A, Lyon SC, Fard AM, Edelman ER, Tearney GJ, Jaffer FA
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence
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2015 年 12 月 Eur Heart J
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Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic
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2015 年 12 月 Invest Ophthalmol Vis Sci 56・13 7839-46
Chen A, Akinyemi RO, Hase Y, Firbank MJ, Foster V, Craggs L, Washida K, Okamoto Y, Thomas AJ, Polvikoski
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Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke
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2016 年 Brain 139・139 242-258
Fujii H, Yonekura Y, Yamashita Y, Kono K, Nakai K, Goto S, Sugano M, Goto S, Fujieda A, Ito Y, Nishi S
Anti-oxidative effect of AST-120 on kidney injury after myocardial infarction
2016 年 1 月 Br J Pharmacol
Sakaguchi M, Hisamori S, Oshima N, Sato F, Shimono Y, Sakai Y
miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells Through the Inhibition of DCLK1
2016 年 1 月 Mol Cancer Res 14 354-362
Hosooka T, Ogawa W
A novel role for the cell cycle regulatory complex cyclin D1-CDK4 in gluconeogenesis
2016 年 1 月 J Diabetes Investig 7・1 27-8
Geng X, Mandai K, Maruo T, Wang S, Fujiwara T, Mizoguchi A, Takai Y, Mori M
Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3
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2016 年 1 月 Genes Cells 21・1 88-98
Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G,
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PKN3 is the major regulator of angiogenesis and tumor metastasis in mice
2016 年 1 月 Sci Rep 6 18979
Cui CY, Sima J, Yin M, Michel M, Kunisada M, Schlessinger D
Identification of potassium and chloride channels in eccrine sweat glands
2016 年 2 月 J Dermatol Sci 81・2 129-31
Haruta H, Hiro T, Mitsumata M, Takayama T, Sudo M, Li Y, Takahashi R, Taniguchi Y, Shiomi M, Hirayama A
Stabilization of atherosclerotic plaque by pitavastatin in Watanabe heritable hyperlipidemic rabbits: A serial
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2016 年 2 月 J Cardiol 67・2 205-11
Maruo T, Mandai K, Takai Y, Mori M
Activity-dependent alteration of the morphology of a hippocampal giant synapse
2016 年 3 月 Mol Cell Neurosci 71 25-33
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for
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2016 年 3 月 J Biol Chem 291・11 5817-31
細岡 哲也, 小川 渉
インスリン作用の Key Molecules PDK1
2015 年 8 月 Diabetes Frontier 26・4 号
499-503
疾患モデルの作製と利用 脂質代謝異常と関連疾患 / 血管内皮リパーゼ
エル・アイ・シー
2015 年 安田知行, 石田達郎 分担執筆 p450-p456
Neuroprotection and nueroregeneration for retinal diseases / Aquaporin in optic neuropathies
Springer
2015 年 Akiyasu Kanamori 分担執筆 p161-p173
Bioactive Lipid Mediators Current Reviews and Protocols / Part III Lipid Mediators and Diseases, 22. Roles and
actions of arachidonic acid-derived bioactive lipids in stress-related behaviors
Springer
2016 年 3 月 Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang and Takumi
Fukumoto 分担執筆 p324-p324
INTECH / Medical Application of Nonwoven Fabrics - Intra-abdominal Spacers for Particle Therapy
INTECH
2016 年 3 月 細岡哲也, 小川渉 分担執筆 p122-p125
心血管事故を予防するための糖尿病治療戦略 / 糖尿病治療の最前線－メトホルミンの作用機序に関して
教えてください－
文光堂
2016 年 3 月 細岡哲也, 小川渉 分担執筆 p122-p125