五月人形 雄山 Mermaid 鎧 鎧兜 鎧飾り 甲冑 徳川家康 子供の日 端午

Liver Fibrosis Model
Bile Duct Ligation Model of Liver Fibrosis
Model&ExperimentalDetails
•  Species: Wistar Rat
•  Model: Surgical Ligation of the Common Bile Duct
•  Duration: 3 Weeks (Range of 1-6 weeks is typical)
•  Endpoints: Serum, Tissue and Histopathological Markers of Fibrosis and Damage
LiverHydroxyprolineContent
0.5
TissueHypertrophy
0.3
0.2
0.1
0.0
6
40
2
20
0
Spleen
12
600
150
9
400
100
200
50
Week
2
3
mg/dL
200
1
Liver
Bilirubin
ALT (Units/L)
AST & ALP (Units/L)
60
4
BDL
AST
ALP
ALT
0
80
*
LiverEnzymes
0
*
0
Sham
800
100
Liver Weight
(g/BW)
Spleen Weight
(g/BW)
0.4
Hydroxyproline
(µg/mg tissue)
Sham
BDL
8
*
0
Total
Direct
6
3
0
0
1
Week
2
3
* p<0.05 vs. SHAM, n=10-12/group
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