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【課題】本発明は、リウマチ患者においてTNF阻害薬による治
JP 2010-88432 A 2010.4.22 (57)【要約】 【課題】本発明は、リウマチ患者においてTNF阻害薬による治療の有効・無効および副作 用発現に関連する遺伝子、および、該遺伝子または該遺伝子の近傍DNAに存在する、該有 効・無効および副作用発現が起こるか否かを検査する方法を提供することを課題とする。 【解決手段】本発明者らは、上記課題を解決するために、TNF阻害薬治療による有効性・ 副作用発現の判定に焦点を当て、関節リウマチ治療におけるTNF阻害薬治療による有効性 ・副作用発現に関与するSNPsを全ゲノムより解析した。TNF阻害薬治療中の患者のゲノムD NAと臨床情報を使用することにより、関節リウマチ患者におけるTNF阻害薬治療の有効性 または副作用発現に関連する多型を見出した。 【選択図】なし 10 (2) JP 2010-88432 A 2010.4.22 【特許請求の範囲】 【請求項１】 被験者について、配列番号1∼14813に記載された１以上の塩基配列、該塩基配列の近傍 DNA領域、遺伝子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、TNF阻害 薬の関節リウマチ治療における有効性の有無、および／または副作用が起こるか否かを検 出する方法。 【請求項２】 TNF阻害薬がエタネルセプト、アダリムマブおよび／またはインフリキシマブであり、 被験者について配列番号14425∼14545に記載された１以上の塩基配列、該塩基配列の近傍 DNA領域、遺伝子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、請求項１ 10 に記載の方法。 【請求項３】 TNF阻害薬が抗TNF抗体製剤であり、被験者について配列番号4472∼9722、10172∼14424 、14546∼14813に記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該 遺伝子の近傍DNA領域における変異を検出する工程を含む、請求項１に記載の方法。 【請求項４】 抗TNF抗体がモノクローナル抗体である、請求項３に記載の方法。 【請求項５】 抗TNF抗体がキメラ型抗体、ヒト化抗体及びヒト型抗体からなる群より選ばれるモノク ローナル抗体またはその一部からなる抗体である、請求項４に記載の方法。 20 【請求項６】 抗TNF抗体製剤がインフリキシマブおよびアダリムマブであり、被験者について配列番 号14546∼14813に記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該 遺伝子の近傍DNA領域における変異を検出する工程を含む、請求項３に記載の方法。 【請求項７】 抗TNF抗体製剤がインフリキシマブであり、被験者について配列番号8397∼9722に記載 された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域に おける変異を検出する工程を含む、請求項３に記載の方法。 【請求項８】 抗TNF抗体製剤がアダリムマブであり、被験者について配列番号10172∼14424に記載さ 30 れた１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域にお ける変異を検出する工程を含む、請求項３に記載の方法。 【請求項９】 TNF阻害薬がエタネルセプトであり、被験者について配列番号9723∼10171に記載された １以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における 変異を検出する工程を含む、請求項１に記載の方法。 【請求項１０】 変異が一塩基多型である、請求項１∼９のいずれかに記載の方法。 【請求項１１】 抗TNF阻害薬の有効性がDAS28ESRまたはDAS28CRPにより評価される、請求項１∼１０の 40 いずれかに記載の方法。 【請求項１２】 請求項１０に記載の多型部位を含むDNAにハイブリダイズし、少なくとも15ヌクレオチ ドの鎖長を有するオリゴヌクレオチドを含む抗TNF阻害薬の関節リウマチ治療における有 効性の有無、および／または副作用が起こるか否かを検査するための薬剤。 【請求項１３】 請求項１０に記載の多型部位を含むDNAとハイブリダイズするヌクレオチドプローブが 固定された固相からなる、抗TNF阻害薬の関節リウマチ治療における有効性の有無、およ び／または副作用が起こるか否かを検査するための薬剤。 【請求項１４】 50 (3) JP 2010-88432 A 2010.4.22 請求項１０に記載の多型部位を含むDNAを増幅するためのプライマーオリゴヌクレオチ ドを含む、抗TNF阻害薬の関節リウマチ治療における有効性の有無、および／または副作 用が起こるか否かを検査するための薬剤。 【発明の詳細な説明】 【技術分野】 【０００１】 本発明は、関節リウマチ患者（以下RAと表記することもある）へのTNF阻害薬による治 療の有効性・副作用発現に関連する遺伝子、および、該遺伝子または該遺伝子の近傍DNA に存在する、該有効性・副作用に関連する多型に関する。また、該多型を利用したTNF阻 害薬治療による有効性・副作用発現が起こるか否かを検査する方法に関する。 10 【背景技術】 【０００２】 関節リウマチ(RA)の病態は、関節炎を中心とする全身性の慢性炎症疾患である。RAはも っとも頻度の高い膠原病であり、その有病率は世界人口の約1%、我が国人口の0.6%(約70 万人)であるとみられている。また、RAは遺伝要因と環境要因により発症が規定される多 因子疾患であり、さらに、複数の遺伝要因が関与していると考えられていること、病態に は自己免疫反応や炎症反応といった多段階の事象が関与することなどから、原因や病態に 関してはいまだに不明な点が多い。 【０００３】 キメラ型抗TNF-α抗体であるインフリキシマブ（infliximab）、完全ヒト型抗体である 20 アダリムマブ（adalimumab）、可溶性TNFレセプターであるエタネルセプト（etanercept ）は関節炎に対して高い有効性を示すのみならず、関節組織破壊抑制作用を有する。しか し、TNF阻害薬治療には重篤な副作用が知られている。また、重篤な副作用以外にもイン フリキシマブ投与中あるいは投薬終了後2時間までの間にアナフィラキシー様症状が起こ る場合がある。また、投与後3日以上経過後に遅延型過敏症（発疹、発熱、掻痒感、頭痛 、手または顔面浮腫など）が報告されている。インフリキシマブ投与による副作用発現頻 度は非常に高く、国内臨床試験では全症例の78.3%において副作用発現が見られた。エタ ネルセプトに特有な副作用として注射部反応（紅斑、掻痒感、疼痛、腫脹）があり、約30 %の症例で発現する。アダリムマブはエタネルセプトと同様に皮下注射であるため、注射 部反応が見られる。このような副作用発現は、臨床的に重大な問題となっている。 30 【０００４】 一方、TNF阻害療法にて治療しても、約30%の人には無効である。TNF阻害薬はいずれも 高価な薬剤であるため、TNF阻害薬の有効・無効を予め予測することは医療経済上でも重 要である（非特許文献３６）。 【０００５】 TNF阻害薬治療の有効・無効の判定および、副作用発現が遺伝的な要因によって説明さ れる可能性を、本発明者らは検討した。TNF阻害薬治療の有効・無効の判定および、副作 用発現に関与している可能性のある遺伝子は既にいくつか報告されてはいるが、それらの 遺伝子が実際に有効・無効の判定および、副作用発現に関与しているという報告は、これ までにない。 40 【０００６】 インフリキシマブはヒト−マウスキメラモノクローナル抗体であり、TNF-αと結合する 可変領域のみがマウスIgG由来（約25%）のアミノ酸配列を有し、それ以外の定常領域（残 りのFab部分とすべてのFc部分）はヒトIgG由来のアミノ酸配列を有している（非特許文献 ２）。このことに起因して、インフリキシマブの投与を受けた患者の一部の血中には、ヒ ト−マウスキメラ抗体に対する抗体であるHuman anti chimeric antibody（HACA）が検出 されることがある。例えば、大規模な臨床試験であるATTRACTの結果では、約10％の患者 でHACAの産生が認められたと報告されている（非特許文献３）。半数近くの投与患者でHA CAの産生が認められたとする報告も存在する（非特許文献４）。 【０００７】 50 (4) JP 2010-88432 A 2010.4.22 インフリキシマブは即効性であり、投与早期より有効性が認められるが、すべての症例 で有効というわけではなく、2-3割の一次無効症例（最初から効かない）やいったん効果 が現れた後再び関節炎が悪化する二次無効症例（効果の減弱）も認められる。二次無効症 例の原因としてインフリキシマブの半減期は8∼10日のため投与間隔が8週間隔になると血 中濃度が維持できなくなる可能性や、反復投与でHACAの産生が誘導され、HACAによりイン フリキシマブが中和されるため効果の減弱が認められると示唆されている（非特許文献４ 、非特許文献５）。また、HACAが検出される患者では、検出されなかった患者と比較して 、インフリキシマブ注射時の副作用の１つであるinfusion reactionの発現が多い傾向に ある（非特許文献５）。インフリキシマブ投与を中断し、再び投与を開始した際に投与後 数週間後に皮膚に硬化性浮腫症を認めた関節リウマチ患者において高力価のHACAが検出さ 10 れた例も報告されている（非特許文献６）。 【０００８】 インフリキシマブの副作用の中にはアナフィラキシーショックを伴う重篤な例が存在し 、副作用の発現を予測することは極めて意義が高い。さらに、インフリキシマブは高価な 薬剤であるため、インフリキシマブの有効・無効を予め予測することは医療経済上でも重 要である。そのため、インフリキシマブの有効・無効を予測するマーカーについては多く の探索がなされ、いくつかのマーカーが報告されている。インフリキシマブを関節リウマ チ患者に投与したときの有効・無効の予測をするための遺伝的多型マーカーとして、イン フリキシマブの抗原である腫瘍壊死因子アルファ（TNFα）遺伝子の-308位（非特許文献 ７）、-238および+489（非特許文献８）、IgGFc受容体IIIa型の158位のアミノ酸V/F多型 20 （非特許文献９）、HLA-DRB1 Shared epitope(SE)（非特許文献１０）、などが報告され ている。また、抗好中球細胞質抗体（ANCA：antineutrophil cytoplasmic antibody）の 有無（非特許文献１１）との関連も報告されているが、未だ実用化には至っていない。ま た、インフリキシマブの副作用を予測するマーカーとしては、HACAの産生との関連が示唆 されるのみである。 【０００９】 インフリキシマブはクローン病の治療にも用いられているが、クローン病においてもHA CAの産生が認められる場合にはinfusion reactionが発現する頻度が高く、インフリキシ マブの効果が持続する時間が短くなることが報告されている（非特許文献１２）。 【００１０】 30 また、HACA以外にインフリキシマブの有効・無効を予測する因子として、クローン病の 診断にも利用されるマーカーである抗好中球細胞質抗体（pANCA）および抗saccharomyces cerevisiae抗体が挙げられる（非特許文献１３）。 【００１１】 遺伝的なマーカーとしては、腫瘍壊死因子アルファ（TNFα）遺伝子の-308位（非特許 文献１４）をはじめ、腫瘍壊死因子アルファ（TNFα）受容体遺伝子１（TNFR1）の36位A/ G変異および腫瘍壊死因子アルファ（TNFα）受容体遺伝子２（TNFR2）の587位T/G変異（ 非特許文献１５）、Fasリガンドの-843位のCC/CT遺伝子型（非特許文献１６）、IBD5遺伝 子上のクローン病の疾患感受性と関連する多型（非特許文献１７）、IgGFc受容体IIIa型 の158位のアミノ酸V/F多型（非特許文献１８）等を挙げることができる。 40 【００１２】 また、クローン病の治療のために、初回投与より15ヶ月後に２回目のインフリキシマブ 投与を受け、１週間以内に呼吸困難、発熱等の遅延型のinfusion reactionを起こした患 者の血中に高濃度のHACAが検出されたという報告（非特許文献１９）、クローン病および 潰瘍性大腸炎患者においてHACAの産生が認められた患者ではinfusion reactionの発現率 が高くインフリキシマブの効果持続時間も短いこと（非特許文献２０、非特許文献２１） などが知られている。 【００１３】 アダリムマブは、インフリキシマブのキメラ抗体であり、点滴静注で使用するため、抗 キメラ抗体（HACA）の出現に伴う投薬時反応と効果の減弱してしまうという問題点を改善 50 (5) JP 2010-88432 A 2010.4.22 するために開発された完全ヒト型抗TNF-αモノクローナル抗体である。完全ヒト型である ため、中和抗体による効果の減弱が起こりにくいと考えられ、それによる効果減弱やアナ フィラキシーなどの副作用が少ないと期待されている。しかし、実際には投与患者の約5 ∼10%の割合で中和抗体が産生され、MTX併用によりその出現頻度は5%以下に減少すると報 告されている（非特許文献２２、非特許文献２３） アダリムマブで最も頻度の高い副作用は、注射部位反応（紅斑、掻痒感、疼痛、腫脹） で、治験では20.9%で認められた。 【００１４】 エタネルセプトは完全ヒト型可溶性TNF/LTαレセプター製剤であり、インフリキシマブ とは異なり中和抗体はほとんど検出されない。日本においてはエタネルセプトの市販後全 10 例登録制がとられており、約3000例の時点で中間報告が公表され、約30.9%の症例におい て副作用が発現したと報告されている（非特許文献２４）。また、エタネルセプトは注射 製剤であることから、注射部位反応（紅斑、掻痒感、疼痛、腫脹）が40∼50%に認められ る。 【００１５】 なお、本出願の発明に関連する先行技術文献情報を以下に示す。 【先行技術文献】 【非特許文献】 【００１６】 【非特許文献１】Knight DM. et al., Mol Immunol 1993;30:1443-53 20 【非特許文献２】Scallon BJ. et al., Cytokine 1995;7:251-9 【非特許文献３】Harriman G. et al., Ann Rheum Dis 1999;58:(Suppl I) I61-64 【非特許文献４】Wolbink GJ. et al., Arthritis Rheuma. 2006;54(3):711-5 【非特許文献５】レミケード(R)点滴静注用100添付文書第６版 【非特許文献６】Ranganathan P. J Clin Rheumatol. 2005;11(6):319-22 【非特許文献７】Mugnier B. et al., Arthritis Rheum. 2003;48(7):1849-52 【非特許文献８】Fabris M. et al., Reumatismo. 2002;54(1):19-26 【非特許文献９】Tutuncu Z. et al., Arthritis Rheum. 2005;52(9):2693-6 【非特許文献１０】Marotte H. et al., Ann Rheum Dis. 2006;65(3):342-7 【非特許文献１１】Taylor KD. et al., Gastroenterology. 2001;120(6):1347-55 30 【非特許文献１２】Baert F. et al., New Engl J Med 2003;348(7):601-7 【非特許文献１３】Arnott et al., Aliment Pharmacol. Ther. 2003;17:1451-7 【非特許文献１４】Su et al., Advanced Drug Delivery Reviews 2005;57:237-45 【非特許文献１５】Pierik et al., Aliment Pharmacol Ther. 2004;20(3):303-10 【非特許文献１６】Hlavaty et al., Aliment Pharmacol Ther. 2005;22(7):613-26 【非特許文献１７】Urcelay et al., World J Gadstroenterol. 2005;11(8):1187-92 【非特許文献１８】Louis et al., Aliment Pharmacol Ther. 2004;19(5):511-9 【非特許文献１９】Riegert-Johnson DL. et al., Inflamm Bowel Des. 2002;8(3):186-9 1 【非特許文献２０】Miele E. et al., J Pediatr Gastroenterol Nutr. 2004;38(5):502- 40 8 【非特許文献２１】Sandborn WJ. et al., Curr Gastroenterol Rep. 2003;5(6):501-5 【非特許文献２２】Weaver,W et al., Mod.Rheum.,14:1-14,2004. 【非特許文献２３】Takeuchi,T. et al., Allergol.Int.,54:191-202,2005. 【非特許文献２４】井上和彦 リウマチ科,37:7-16,2007 【非特許文献２５】Tutuncu Z et al., Arthritis Rheum. 2005 Sep;52(9):2693-6 【非特許文献２６】Cuchacovich M et al., Scand J Rheumatol. 2006 Nov-Dec;35(6):43 5-40 【非特許文献２７】Seitz M et al., Rheumatology (Oxford). 2007 Jan;46(1):93-6 【非特許文献２８】Miceli-Richard C et al., Ann Rheum Dis. 2008 Apr;67(4):478-84 50 (6) JP 2010-88432 A 2010.4.22 【非特許文献２９】Ongaro A et al., Rheumatol Int. 2008 Jul;28(9):901-8 【非特許文献３０】Padyukov L et al., Ann Rheum Dis. 2003 Jun;62(6):526-9 【非特許文献３１】Criswell LA et al., Arthritis Rheum. 2004 Sep;50(9):2750-6 【非特許文献３２】Hughes LB et al., Genes Immun. 2004 Dec;5(8):641-7 【非特許文献３３】Kang CP et al., Rheumatology (Oxford). 2005 Apr;44(4):547-52 【非特許文献３４】Schotte H et al., Ann Rheum Dis. 2005 Apr;64(4):575-81 【非特許文献３５】Guis S et al., Arthritis Rheum. 2007 Dec 15;57(8):1426-30 【非特許文献３６】舟橋恵子ら 医学と薬学, 61(3) : 337-343, 2009. 【発明の概要】 【発明が解決しようとする課題】 10 【００１７】 本発明は、このような状況に鑑みてなされたものであり、その目的は、TNF阻害薬治療 による有効性・副作用発現に関連する遺伝子、および、該遺伝子または該遺伝子の近傍DN Aに存在する、該有効性・副作用に関連する多型を提供することにある。また、該多型を 利用したTNF阻害薬による治療の有効性・副作用発現が起こるか否かを判定する方法を提 供することにある。 【課題を解決するための手段】 【００１８】 本発明者らは、上記課題を解決するために、TNF阻害薬治療による有効性・副作用発現 の判定に焦点を当て、関節リウマチ治療におけるTNF阻害薬治療による有効性・副作用発 20 現に関与する一塩基多型（SNPs）を全ゲノムより解析した。 その結果TNF阻害薬治療中の患者のゲノムDNAと臨床情報を使用することにより、関節リ ウマチ患者におけるTNF阻害薬治療の有効性または副作用発現に関連する多型を見出した 。 【００１９】 本発明は、より具体的には以下の〔１〕∼〔１４〕を提供するものである。 〔１〕 被験者について、配列番号1∼14813に記載された１以上の塩基配列、該塩基配列 の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、TN F阻害薬の関節リウマチ治療における有効性の有無、および／または副作用が起こるか否 かを検出する方法。 30 〔２〕 TNF阻害薬がエタネルセプト、アダリムマブおよび／またはインフリキシマブで あり、被験者について配列番号14425∼14545に記載された１以上の塩基配列、該塩基配列 の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、〔 １〕に記載の方法。 〔３〕 TNF阻害薬が抗TNF抗体製剤であり、被験者について配列番号4472∼9722、10172 ∼14424、14546∼14813に記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝 子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、〔１〕に記載の方法。 〔４〕 抗TNF抗体がモノクローナル抗体である、〔３〕に記載の方法。 〔５〕 抗TNF抗体がキメラ型抗体、ヒト化抗体及びヒト型抗体からなる群より選ばれる モノクローナル抗体またはその一部からなる抗体である、〔４〕に記載の方法。 40 〔６〕 抗TNF抗体製剤がインフリキシマブおよびアダリムマブであり、被験者について 配列番号14546∼14813に記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝 子、該遺伝子の近傍DNA領域における変異を検出する工程を含む、〔３〕に記載の方法。 〔７〕 抗TNF抗体製剤がインフリキシマブであり、被験者について配列番号8397∼9722 に記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA 領域における変異を検出する工程を含む、〔３〕に記載の方法。 〔８〕 抗TNF抗体製剤がアダリムマブであり、被験者について配列番号10172∼14424に 記載された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領 域における変異を検出する工程を含む、〔３〕に記載の方法。 〔９〕 TNF阻害薬がエタネルセプトであり、被験者について配列番号9723∼10171に記載 50 (7) JP 2010-88432 A 2010.4.22 された１以上の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域に おける変異を検出する工程を含む、〔１〕に記載の方法。 〔１０〕 変異が一塩基多型である、〔１〕∼〔９〕のいずれかに記載の方法。 〔１１〕 抗TNF阻害薬の有効性がDAS28ESRまたはDAS28CRPにより評価される、〔１〕∼ 〔１０〕のいずれかに記載の方法。 〔１２〕 〔１０〕に記載の多型部位を含むDNAにハイブリダイズし、少なくとも15ヌク レオチドの鎖長を有するオリゴヌクレオチドを含む抗TNF阻害薬の関節リウマチ治療にお ける有効性の有無、および／または副作用が起こるか否かを検査するための薬剤。 〔１３〕 〔１０〕に記載の多型部位を含むDNAとハイブリダイズするヌクレオチドプロ ーブが固定された固相からなる、抗TNF阻害薬の関節リウマチ治療における有効性の有無 10 、および／または副作用が起こるか否かを検査するための薬剤。 〔１４〕 〔１０〕に記載の多型部位を含むDNAを増幅するためのプライマーオリゴヌク レオチドを含む、抗TNF阻害薬の関節リウマチ治療における有効性の有無、および／また は副作用が起こるか否かを検査するための薬剤。 【発明の効果】 【００２０】 本発明によって、TNF阻害薬による治療の有効・無効および副作用発現に関連する遺伝 子、および、該遺伝子上または該遺伝子の近傍DNA領域における変異を検出することによ り、TNF阻害薬による治療の有効・無効および副作用発現があるか否か、すなわちTNF阻害 薬による治療の有効・無効および副作用発現を検査する方法が提供された。本発明の遺伝 20 子上または該遺伝子の近傍DNA領域における多型を検出することで、当該リウマチ患者に おいてTNF阻害薬による治療を受ける際に有効・無効および副作用発現があるか否かが予 測可能となる。 【００２１】 また、本発明によりリウマチ患者へのTNF阻害薬治療におけるより効率的な戦略（いわ ゆるオーダーメイド医療）を立てることが可能になる。具体的にはTNF阻害薬による治療 を受ける際に有効・無効および副作用発現があるか否かを診断することにより、当該TNF 阻害薬が有効であるか判定、または副作用が出現するか判定することができる。すなわち TNF阻害薬が有効でも副作用発現があると予測された患者は、MTX等を併用する等の治療方 針を決める際の一助となりうるし、さらにTNF阻害薬による副作用を予防するような新た 30 な治療薬の開発にもつながる可能性があり大いに期待される。 【図面の簡単な説明】 【００２２】 【図１】本発明における各生物製剤ならびに分析結果の位置づけを示す図である。本発明 においては、TNF阻害薬群（インフリキシマブ・アダリムマブ・エタネルセプト、全ての 投薬治療群）、抗体製剤群（インフリキシマブ・アダリムマブ投薬群）、インフリキシマ ブ投薬群、インフリキシマブ投薬一次無効群、インフリキシマブ投薬二次無効群、エタネ ルセプト投薬群、アダリムマブ投薬群の７群においてそれぞれDAS28ESR有効判定、DAS28C RP有効判定、副作用発現との関連を分析した。 【発明を実施するための形態】 40 【００２３】 本発明者らによって、TNF阻害薬治療による有効性・副作用発現に関連する遺伝子およ び多型が同定された。TNF阻害薬治療による有効性・副作用発現を発症する患者において は、有意にこれら遺伝子または該遺伝子の近傍DNA領域において変異が見出されることか ら、該遺伝子または該遺伝子の近傍DNA領域における変異の有無を調べることにより、被 検者にTNF阻害薬を投与した場合に、関節リウマチにおける有効性の有無、および／また は副作用が起こるか否かの検査を行うことが可能である。 本発明において有効性の検査とは、TNF阻害薬（例えば、インフリキシマブ）に対する 一次無効の検査、または二次無効の検査が含まれる。 【００２４】 50 (8) JP 2010-88432 A 2010.4.22 腫瘍壊死決定因子（tumor necrosis factor:TNF）は、in vitroで腫瘍細胞の分裂阻止 や融解作用があることから命名された液性因子であるが、現在ではIL-1、IL-6などととも に炎症性サイトカインの一つと考えられ、様々なサイトカイン、副刺激分子（接着分子） 、蛋白分解酵素、プラスタグランジンなどの発現を誘導する。サイトカインなどの液性因 子は相互作用も多く、その作用機構はサイトカインネットワークとも呼称される。 【００２５】 TNF-αはサイトカインネットワークの最上流に位置すると考えられており、関節リウマ チ(rheumatoid arthritis:RA)における滑膜炎や関節破壊等、病態に密接に関わっており 、TNF阻害療法が注目されている。 TNFにはTNF-αとTNF-βという2つの分子が存在するが、主要な働きをしているのはTNF- 10 αで、TNF-βの生物活性はTNF-αとほぼ同様であるがその作用は弱い。 【００２６】 TNF受容体は、分子量55 kDaのTNF-R1(p55)と分子量75 kDaのTNF-R2(p75)の2種類が存在 している。TNF-αが3量体となってTNF受容体に結合するとシグナル伝達が開始される。TN F受容体は酵素の作用によって切断されて可溶性TNF受容体となるが、可溶性TNF受容体はT NFに結合することにより、TNF受容体依存性のシグナル伝達を阻害する。 【００２７】 本発明においてTNF阻害薬とは、TNFの活性を阻害する薬剤をいう。作用機序は特に限定 されず、TNF-αまたはTNF-βを直接阻害するものであってもよいし、TNF受容体の活性を 阻害するものであってもよい。 20 【００２８】 TNF-αを直接阻害するTNF阻害薬の具体的な例としては、インフリキシマブおよびアダ リムマブを挙げることができる。インフリキシマブ、アダリムマブの作用機序は分泌型お よび膜結合型TNF-αと特異的かつ不可逆的に結合することによりTNF受容体に対するリガ ンド活性を阻害し、さらにTNF-αの生体における除去を促進する。また、膜結合型TNF-α に結合し、補体活性あるいはADCC（抗体依存性細胞障害）活性を介して産生細胞を障害し うる。 【００２９】 一方、TNF受容体の活性を阻害するTNF阻害薬の具体的な例としては、エタネルセプトを 挙げることができる。エタネルセプトはリガンドであるTNF-αとTNF-β（リンホトキシン 30 ）に対して高い親和性を示し、膜結合型TNF受容体への結合を拮抗阻害することにより、 両方のTNF活性を阻害する。 【００３０】 本発明で使用されるTNF阻害薬は、自己免疫疾患、炎症性疾患、敗血症、悪液質、移植 片対宿主病等の疾患の治療薬として使用されている。 本発明のTNF阻害薬としては、抗TNF-αモノクローナル抗体製剤、TNF受容体（TNFR）に 対する可溶性受容体製剤を挙げることができる。本発明の抗TNF-αモノクローナル抗体製 剤として、具体的にはインフリキシマブ、アダリムマブなどを例示することができる。ま た、可溶性受容体製剤としては、エタネルセプトを例示することができる。 【００３１】 40 本発明のTNF阻害薬を投与される被検者は、自己免疫疾患、敗血症、悪液質、移植片対 宿主病、ベーチェット病、強直性脊椎炎、乾癬、サルコイドーシス、炎症性皮膚疾患、骨 髄異形成症候群、難治性ブドウ膜炎、成人スティル病等の疾患を発症していることが好ま しい。本発明の被検者が発症している疾患として、より好ましくは、自己免疫疾患、炎症 性疾患であり、さらに好ましくは関節リウマチ、クローン病である。 【００３２】 本発明において抗TNF-αモノクローナル抗体製剤は、ヒトTNF-αのみに特異的に結合し 、TNF-αの機能を抑制する。 【００３３】 本発明において抗TNF抗体は、公知の手段を用いてポリクローナル又はモノクローナル 50 (9) JP 2010-88432 A 2010.4.22 抗体として得ることができる。本発明で使用される抗TNF抗体として、特に哺乳動物由来 のモノクローナル抗体が好ましい。哺乳動物由来のモノクローナル抗体としては、ハイブ リドーマに産生されるもの、および遺伝子工学的手法により抗体遺伝子を含む発現ベクタ ーで形質転換した宿主に産生されるものがある。この抗体はヒトTNFに特異的に結合し、T NFの機能を抑制する。 【００３４】 TNFを認識する抗体は、該タンパク質と結合する限り特に制限はなく、マウス抗体、ラ ット抗体、ウサギ抗体、ヒツジ抗体、ヒト抗体等を適宜用いることができる。又、ヒトに 対する異種抗原性を低下させること等を目的として人為的に改変した遺伝子組換え型抗体 、例えば、キメラ（Chimeric）抗体、ヒト化（Humanized）抗体なども使用できる。これ 10 らの改変抗体は、既知の方法を用いて製造することができる。 【００３５】 キメラ抗体はヒトに対する異種抗原性を低下させること等を目的として人為的に改変し た遺伝子組換え型抗体である。キメラ抗体は、ヒト以外の哺乳動物、例えば、マウス抗体 、ラット抗体、ウサギ抗体、ヒツジ抗体等の重鎖、軽鎖の可変領域とヒト抗体の重鎖、軽 鎖の定常領域からなる抗体である。キメラ抗体は、例えばマウス抗体の可変領域をコード するDNAをヒト抗体の定常領域をコードするDNAと連結し、これを発現ベクターに組み込ん で宿主に導入し産生させることにより得ることができる（欧州特許出願公開番号EP 12502 3）。 【００３６】 20 ヒト化抗体は、再構成（reshaped）ヒト抗体とも称され、ヒト以外の哺乳動物、たとえ ばマウス抗体の相補性決定領域（CDR; complementarity determining region）をヒト抗 体の相補性決定領域へ移植したものであり、その一般的な遺伝子組換え手法も知られてい る。具体的には、マウス抗体のCDRとヒト抗体のフレームワーク領域（framework region ；FR）を連結するように設計したDNA配列を、末端部にオーバーラップする部分を有する ように作製した数個のオリゴヌクレオチドからPCR法により合成する。得られたDNAをヒト 抗体定常領域をコードするDNAと連結し、次いで発現ベクターに組み込んで、これを宿主 に導入し産生させることにより得られる。CDRを介して連結されるヒト抗体のFRは、相補 性決定領域が良好な抗原結合部位を形成するものが選択される。必要に応じ、再構成ヒト 抗体の相補性決定領域が適切な抗原結合部位を形成するように抗体の可変領域のフレーム 30 ワーク領域のアミノ酸を置換してもよい。 【００３７】 また、ヒト抗体の取得方法も知られている。例えば、ヒトリンパ球をin vitroで所望の 抗原または所望の抗原を発現する細胞で感作し、感作リンパ球をヒトミエローマ細胞、例 えばU266と融合させ、抗原への結合活性を有する所望のヒト抗体を得ることもできる（特 公平1-59878参照）。また、ヒト抗体遺伝子の全てのレパートリーを有するトランスジェ ニック動物を所望の抗原で免疫することで所望のヒト抗体を取得することができる。さら に、ヒト抗体ライブラリーを用いて、パンニングによりヒト抗体を取得する技術も知られ ている。例えば、ヒト抗体の可変領域を一本鎖抗体（scFv）としてファージディスプレイ 法によりファージの表面に発現させ、抗原に結合するファージを選択することができる。 40 選択されたファージの遺伝子を解析すれば、抗原に結合するヒト抗体の可変領域をコード するDNA配列を決定することができる。抗原に結合するscFvのDNA配列が明らかになれば、 当該配列を有する適当な発現ベクターを作製し、ヒト抗体を取得することができる。 【００３８】 本発明に使用する抗体は、ポリエチレングリコール（PEG）、放射性物質、トキシン等 の各種分子と結合したコンジュゲート抗体でもよい。このようなコンジュゲート抗体は、 得られた抗体に化学的な修飾を施すことによって得ることができる。なお、抗体の修飾方 法はこの分野においてすでに確立されている。本発明における「抗体」にはこれらのコン ジュゲート抗体も包含される。 【００３９】 50 (10) JP 2010-88432 A 2010.4.22 本発明において「抗TNF抗体」とは、好ましくは、インフリキシマブ等の抗ヒトTNFαキ メラ型モノクローナル抗体や、アダリムマブ等の抗ヒトTNF完全ヒト型抗体を挙げること ができる。また、現在開発中の完全ヒト化抗TNF-α抗体ゴリムマブ（golimumab）、PEG化 抗-TNF製剤セルトリズマブ ペゴル（certolizumab pegol）も挙げることができる。さら に、本発明の抗TNF抗体には、インフリキシマブまたはアダリムマブと同様の構造を持ち 、同様の活性を有する抗体も含まれる。 【００４０】 本発明においてTNF受容体（TNFR）に対する可溶性受容体製剤は、ヒトTNF-α及びTNFβに結合してデコイレセプターとして働くことにより、TNFと細胞表面のTNF受容体との結 合を阻害し、TNFの生物活性を抑制する。 10 【００４１】 エタネルセプトはヒト腫瘍壊死因子受容体(TNFR)のp75分子の一部の構造を持つ新規生 物学的製剤である。TNFRは通常生体内で細胞表面に発現し、75kDa(p75)と55kDa(p55)の二 種類のタンパクのヘテロダイマーとして存在する。エタネルセプトは投与した際の安定化 を増すために、ヒトTNFRのp75(タイプI)の2分子をヒトIgG1のFc部分と融合するように遺 伝子工学的に設計して、チャイニーズハムスター卵巣細胞（CHO）細胞を利用し、産生さ れた糖タンパク質である（参考：エンブレル(R)皮下注用25mg添付文書第4版）。 さらに、本発明のTNF受容体（TNFR）に対する可溶性受容体製剤には、エタネルセプト と同様の構造を持ち、同様の活性を有する抗体も含まれる。 【００４２】 20 副作用について、世界保健機関（ＷＨＯ）は「有害であって意図されない、疾病の予防 ・診断・治療又は生理学的機能の修正のために、通常の使用量で人に起こる、薬に対する 何らかの反応である」と定義している。また、アメリカの食品医薬品局（ＦＤＡ）は、副 作用を、「人において薬の使用に関係する何らかの有害な結果であって、薬に関連してい るかどうかを問わず専門的実践における薬製品の使用の過程で起こる有害な結果、事故か 意図したものかを問わず薬の適量超過使用から起こる有害な結果、薬の濫用から起こる有 害な結果、薬の使用中止から起こる有害な結果、期待した薬理的効果が有意に発生しない こと含む」と定義している。 【００４３】 本発明において、「TNF阻害薬の有効性の有無を判定する」とは、TNF阻害薬が被験者に 30 おいて関節リウマチの治療効果を有するか否かを判定することをいう。TNF阻害薬の関節 リウマチにおける有効性の判断方法の例としては、DAS(disease activity score)を用い る方法が挙げられる。DASは欧州リウマチ学会議(EULAR)で汎用されている判断方法であり 、疼痛関節数、腫脹関節数、患者の健康状態の全般評価（VASによる）、血沈（ESR）また はCRPの４つの活動性指標を指数化して疾患活動性を算定し、DAS28改善（[治療前のDAS28 ]-[治療後のDAS28]）と評価時のDAS28の値の両方を用いて実施例表１に示すように、「有 効」、「やや有効」、「無効」の３種類の評価を付与する。本発明においてはDAS28のEUL AR改善基準に基づいて有効、やや有効と判定した群を有効群とし、無効と判定した群を無 効群とした。 【００４４】 40 本発明において、「TNF阻害薬の一次無効を判定する」とは、TNF阻害薬としてインフリ キシマブにて治療した際に被験者において投与開始から14週までの間に、関節リウマチの 治療効果を有するか否かを判定することをいう。また、本発明において、「TNF阻害薬の 二次無効を判定する」とは、TNF阻害薬としてインフリキシマブにて治療した際に被験者 において投与開始14週から30週までの間に、関節リウマチの治療効果を有するか否かを判 定することをいう。一次無効、二次無効の判定はDAS28、有効判定を用いて実施例表2に示 すように「有効」、「無効」の２種類の評価を付与する。 【００４５】 本発明において、TNF阻害薬による治療の副作用が起こるとは、抗ヒトTNFαキメラ抗体 を含有する薬剤の使用に関係する、被検者における何らかの有害な結果をいう。本発明に 50 (11) JP 2010-88432 A 2010.4.22 おける副作用の具体的な例としては、当該薬剤の使用の過程で起こる、適量超過使用から 起こる有害な結果、薬の濫用から起こる有害な結果、薬の使用中止から起こる有害な結果 、期待した薬理的効果が有意に発生しないこと等が挙げられる。 【００４６】 より具体的には、投与中または投与初期における過敏反応、投与後におけるTNF阻害薬 の血中濃度の低下により、有効性が低下することもまた、副作用に含まれる。 【００４７】 投与中または投与初期における過敏反応（infusion reaction）としては、アナフィラ キシー反応が例として挙げられ、具体的な症状としては、呼吸困難、気管支痙攣、血圧上 昇、血圧低下、血管浮腫、チアノーゼ、低酸素症、熱関係副作用（ほてり、高熱等）、皮 10 膚関係副作用（皮膚紅斑、皮膚発疹、皮膚蕁麻疹、発赤、皮膚掻痒感等）、消化器嘔吐等 が挙げられるが、これらに限定されるものではない。また、infusion reaction以外の副 作用としては日和見感染症（上気道感染症、細菌性肺炎、気管支炎、結核、敗血症、尿路 感染）、全身倦怠感、口内炎、味覚不良、頭痛、悪心、ループス様症候群、脱髄性疾患の 増悪、うっ血性心不全の増悪（心電図異常）、薬剤性肝障害、肝胆道系感染症等が挙げら れるが、これらに限定されるものではない。投与後における抗ヒトTNFαキメラ抗体の血 中濃度の低下の例としては、HACAによる抗ヒトTNFαキメラ抗体の中和反応が挙げられる がこれに限定されるものではない。 【００４８】 HACAを産生しているか否かは、EIA法など公知の方法を用いて測定することができる。 20 また、抗ヒトTNFαキメラ抗体が血中に残存するとは、抗ヒトTNFαキメラ抗体の投与後に 、抗ヒトTNFαキメラ抗体の血中濃度の低下傾向が小さいことをいう。血中濃度の低下傾 向が小さいとは、抗ヒトTNFαキメラ抗体投与一定期間後に抗ヒトTNFαキメラ抗体が血中 に検出されることをいう。具体的には、投与8週後に血中に抗ヒトTNFαキメラ抗体が検出 されること、より好ましくは、初回、2週後、6週後、14週後、22週後の投与後、さらに投 与8週間経過後の投与前の血中に抗ヒトTNFαキメラ抗体が検出されることが挙げられる。 抗ヒトTNFαキメラ抗体の血中濃度は、EIA法等により検出することができる。 【００４９】 本発明におけるTNF阻害薬による治療の有効性・副作用は、TNF阻害薬の投与中に起こっ てもよいし、投与直後、投与初期、または投与後に起こっても良い。 30 【００５０】 本発明において、TNF阻害薬に対する副作用が投与初期におこるとは、抗体投与中∼24 時間、好ましくは２∼３時間以内に副作用が発症することをいう。また、投与後に起こる とは、投与後１日∼４週、好ましくは投与後１∼２週に副作用が起こることをいう。 【００５１】 さらに、本発明の副作用は、抗ヒトTNFαキメラ抗体を含有する薬剤を一回投与するこ とにより起こってもよいし、投与中断後に投与を再開した際に起こっても良いし、また、 連続して投与することによって起こっても良い。 【００５２】 本発明者らによって、TNF阻害薬による関節リウマチ治療において、該ＴＮＦ阻害薬の 40 有効性・副作用と関連することが見出された塩基配列は、DAS28ESR有効性に関する配列番 号1∼1488に示す塩基配列（実施例２表１４）、DAS28CRP有効性に関する配列番号1489∼3 304に示す塩基配列（実施例３表１５）、および副作用に関する配列番号3305∼4471に示 す塩基配列（実施例４表１６）である。 【００５３】 また、本発明者らによって、TNF阻害薬のうち、特にエタネルセプト、アダリムマブお よび／またはインフリキシマブによる関節リウマチ治療において、該薬剤と有効性・副作 用と関連することが見出された塩基配列は、DAS28ESR有効性に関する配列番号14425∼144 75に示す塩基配列（実施例２１表３３）、DAS28CRP有効性に関する配列番号14476∼14522 に示す塩基配列（実施例２２表３４）、および副作用に関する配列番号14523∼14545に示 50 (12) JP 2010-88432 A 2010.4.22 す塩基配列（実施例２３表３５）である。 【００５４】 本発明者らによって、TNF抗体製剤による関節リウマチ治療において、該ＴＮＦ抗体製 剤の有効性・副作用と関連することが見出された塩基配列は、以下のDAS28ESR有効性に関 する配列番号4472∼5755に示す塩基配列（実施例５表１７）、DAS28CRP有効性に関する配 列番号5756∼6902に示す塩基配列（実施例６表１８）、および副作用に関する配列番号69 03∼8396に示す塩基配列（実施例７表１９）である。 【００５５】 本発明者らによって、インフリキシマブおよびアダリムマブによる関節リウマチ治療に おいて、該薬剤の有効性・副作用と関連することが見出された塩基配列は、DAS28ESR有効 10 性に関する配列番号14546∼14656に示す塩基配列（実施例２４表３６、３７）、DAS28CRP 有効性に関する配列番号14657∼14760に示す塩基配列（実施例２５表３８、３９）、およ び副作用に関する配列番号14761∼14813に示す塩基配列（実施例２６表４０、４１）であ る。 【００５６】 さらに、本発明において、インフリキシマブによる関節リウマチ治療において、インフ リキシマブの有効性・副作用と関連することが見出された塩基配列は、DAS28ESR有効性に 関する配列番号8397∼8580に示す塩基配列（実施例８表２０）、DAS28CRP有効性に関する 配列番号8581∼8810に示す塩基配列（実施例９表２１）、および副作用に関する配列番号 8811∼9024に示す塩基配列（実施例１０表２２）である。 20 【００５７】 本発明において、インフリキシマブの一次無効と関連することが見出された塩基配列は 、DAS28ESR有効性に関する配列番号9025∼9239に示す塩基配列（実施例１１表２３）、DA S28CRP有効性に関する配列番号9240∼9411に示す塩基配列（実施例１２表２４）である。 【００５８】 また、本発明において、インフリキシマブの二次無効と関連することが見出された塩基 配列はDAS28ESR有効性に関する配列番号9412∼9571に示す塩基配列（実施例１３表２５） 、DAS28CRP有効性に関する配列番号 9572∼9722に示す塩基配列（実施例１４表２６）で ある。 【００５９】 30 本発明において、アダリムマブによる関節リウマチ治療において、アダリムマブの有効 性・副作用と関連することが見出された塩基配列は、DAS28ESR有効性に関する配列番号10 172∼12108に示す塩基配列（実施例１８表３０）、DAS28CRP有効性に関する配列番号1210 9∼13489に示す塩基配列（実施例１９表３１）、および副作用に関する配列番号13490∼1 4424に示す塩基配列（実施例２０表３２）である。 【００６０】 本発明において、エタネルセプトによる関節リウマチ治療において、エタネルセプトの 有効性・副作用と関連することが見出された塩基配列は、DAS28ESR有効性に関する配列番 号9723∼9840に示す塩基配列（実施例１５表２７）、DAS28CRP有効性に関する配列番号98 41∼10003に示す塩基配列（実施例１６表２８）、および副作用に関する配列番号10004∼ 40 10171に示す塩基配列（実施例１７表２９）である。 【００６１】 これら遺伝子の塩基配列、およびそれら遺伝子によってコードされるタンパク質のアミ ノ酸配列に関する情報は、それぞれの実施例表中に記載のGenBankのアクセッション番号 から、容易に取得することが可能である。また当業者においては、表中の遺伝子表記（遺 伝子名）、または列挙した部分配列の情報を基に、公共の遺伝子データベースあるいは文 献データベース等から遺伝子の塩基配列、および該遺伝子によってコードされるタンパク 質のアミノ酸配列に関する情報を容易に入手することが可能である。 【００６２】 上記の知見に基づき、本発明は、被検者について、後述の実施例の表１４∼４１に記載 50 (13) JP 2010-88432 A 2010.4.22 したいずれかの塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域に おける変異を検出することを特徴とする、TNF阻害薬による治療の有効性・副作用が起こ るか否かを判定する方法を提供する。 【００６３】 なお、本発明において「いずれかに記載の塩基配列」、「いずれかに記載の遺伝子」と は、それぞれ、実施例の表１４∼４１に記載のいずれか少なくとも１以上の塩基配列、ま たは遺伝子を意味する。即ち、上記表１４∼４１に記載の複数の塩基配列、該塩基配列の 近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における変異を検出することによって、TN F阻害薬による治療の有効性・副作用が起こるか否かの検査を行う場合も、本発明に含ま れる。 10 【００６４】 本発明において「TNF阻害薬による関節リウマチ治療の有効性の有無、および／または 副作用が起こるか否かの検出」とは、TNF阻害薬による関節リウマチ治療に有効である可 能性が高いか低いか、および／または副作用が起こる可能性が高いか低いかを判定するた めの検査が含まれる。本発明の方法においては、実施例の表１４∼４１に記載したいずれ かの塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域において変異 が検出された場合に、被検者はTNF阻害薬による関節リウマチ治療が有効である、および ／または副作用が起こる、あるいはTNF阻害薬による関節リウマチ治療が有効である、お よび／または副作用が起こる素因を有すると判定される。 【００６５】 20 一方、実施例の表１４∼４１に記載したいずれかの塩基配列、該塩基配列の近傍DNA領 域、遺伝子、該遺伝子の近傍DNA領域において変異が検出されない場合に、被検者はTNF阻 害薬の治療が有効でない、および／または副作用を起こさないと判定される。または、TN F阻害薬による治療が有効でない、および／または副作用が起こる素因を有さないと判定 される。 【００６６】 本発明の方法により、未だ抗ヒトTNF阻害薬を投与していない被検者であっても、TNF阻 害薬による関節リウマチ治療の有効性の有無、および／または副作用が起こるか否かの検 出をすることができる。また既にTNF阻害薬による治療において副作用を発症している被 検者の場合は、副作用が進行する可能性が高いか低いかを判定することができ、TNF阻害 30 薬を投与することによる、疾患の治療方針の決定等に利用する事ができる。 【００６７】 なお、本明細書で用いられる「治療」とは、通常、薬理学的なおよび／または生理学的 な効果を得ることを意味する。効果とは、疾患や症状を完全にあるいは部分的に妨げる点 で予防的であってもよく、疾患の症状を完全にあるいは部分的に治療する点で治療的であ っても良い。本明細書における「治療」とは、哺乳類、特にヒトにおける疾患の治療すべ てを含んでいる。そしてさらに、疾患の素因があるが未だ発病していると診断されていな い被検者の発病の予防、疾患の進行を抑制すること、または疾患を軽減させることなども この「治療」に含まれる。 【００６８】 40 上記本発明の検査方法における「変異」の位置は、予め規定することは困難であるが、 通常、上記遺伝子のORF中、あるいは上記遺伝子の発現を制御する領域（例えば、プロモ ーター領域、エンハンサー領域等）中に存在するが、これらに限定されるものではない。 また、この「変異」とは、上記遺伝子の発現量を変化させる、mRNAの安定性等の性質を変 化させる、あるいは上記遺伝子によってコードされるタンパク質の有する活性を変化させ るような変異であることが多いが、特に制限されない。本発明の変異としては、例えば、 塩基の付加、欠失、置換、挿入変異等を挙げることができる。 【００６９】 本発明者らは、被検者における本発明の表１４∼４１に記載したいずれかの塩基配列、 該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域において、関節リウマチにお 50 (14) JP 2010-88432 A 2010.4.22 けるTNF阻害薬に対する有効性・副作用に対して有意に関連する多型変異を見出すことに 成功した。従って、本発明の表１４∼４１に記載したいずれかの塩基配列、該塩基配列の 近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の多型部位について変異の有無を指標と する（塩基種を決定する）ことにより、関節リウマチにおけるTNF阻害薬に対する有効性 の有無および／または副作用が起こるか否かの検査を行なうことが可能である。 【００７０】 なお、上記の「塩基配列または遺伝子の近傍DNA領域」とは、通常該遺伝子の近傍の染 色体上の領域を指す。近傍とは特に制限されるものではないが、通常、本発明の多型部位 を含むDNA領域であり、好ましくは多型部位または多型部位を含むＬＤブロック(連鎖不平 衡ブロック)の末端部位から10kb以内の領域を指す。 10 【００７１】 前後10 kbすなわち20 kb以内の範囲にある多型は、Gabrielらの報告の通り、連鎖して いる可能性が高い（Gabriel SB, Schaffner SF, Nguyen H et al. The structure of hap lotype blocks in the human genome. Science 296, 2225-9. 2002）。 【００７２】 本発明の好ましい態様においては、本発明の表１４∼４１に記載したいずれかの塩基配 列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における多型変異（多型 部位における塩基種）を検出することを特徴とする、TNF阻害薬による関節リウマチ治療 の有効性の有無、および／または副作用が起こるか否かを検出する方法である。 【００７３】 20 多型とは、遺伝学的には、人口中1%以上の頻度で存在している1遺伝子におけるある塩 基の変化と一般的に定義されるが、本発明における「多型」は、この定義に制限されない 。本発明における多型の種類としては、例えば、一塩基多型、一から数十塩基（時には数 千塩基）が欠失あるいは挿入している多型等が挙げられる。さらに、多型部位の数も、1 個に限定されず、複数個の多型であってもよい。 【００７４】 また本発明は、被検者について、本発明の表１４∼４１に記載したいずれかの塩基配列 、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域における多型部位の塩基種 を決定することを特徴とする、TNF阻害薬による関節リウマチ治療の有効性の有無、およ び／または副作用が起こるか否かを検出する方法を提供する。 30 【００７５】 本発明のTNF阻害薬による関節リウマチ治療の有効性の有無、および／または副作用が 起こるか否かを検出する方法における「多型部位」は、本発明の表１４∼４１に記載した いずれかの塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域に存在 する多型であれば、特に制限されない。具体的には、本発明のTNF阻害薬による関節リウ マチ治療の有効性の有無、および／または副作用が起こるか否かの検出方法に利用可能な 多型部位として、表１４∼４１の『SNPの種類』の欄に記載の多型部位を挙げることがで きる。（なお、本明細書においては、これらの多型部位を単に『本発明の多型部位』と記 載する場合がある）。 【００７６】 40 また、当業者においては掲載されたdbSNPデータベースのrs番号をもとに、当該部位に ついての塩基種の情報を適宜取得することができる。また、NCBI SNPリファレンス欄の記 載内容は、先頭にrsが付くものはdbSNPデータベースの登録IDのうちNCBIにより一配列に 一意に定まるIDを付与されたものである。また、dbSNPデータベースはNCBIウェブサイト （http://www.ncbi.nlm.nih.gov/SNP/index.html）に公開されており、NCBI SNPリファレ ンス欄に記載された登録ID番号を用いてウェブサイト上で検索することにより、塩基配列 におけるSNPsの詳細な情報（例えば、染色体上の位置、多型部位の塩基の種類、前後の配 列等）が入手できる。これらの情報を用いた場合、当業者においては、本発明に記載する 検査を容易に行うことができる。 【００７７】 50 (15) JP 2010-88432 A 2010.4.22 上記表中に示した多型部位の塩基種は配列表に示した配列に対して相補鎖側にある塩基 種を示している場合があるが、本明細書において記載された前後配列、あるいは、dbSNP およびJSNPデータベースにて公開される前後配列を用いれば異同を確認することは当業者 にとって容易であり、検査を行うにあたってはプラス鎖とマイナス鎖のどちらを調べても 必然的にもう一方の結果を決定することができる。なお、現在ヒトゲノム配列については 、ほぼ最終版といわれているヒトゲノム国際プロジェクトbuild36.2が発表されており、 本明細書に記した配列等はヒトゲノム国際プロジェクトbuild36.2の結果に基づいている 。 【００７８】 当業者においては、通常、本明細書において開示された多型に付与された登録ID番号、 10 例えばdbSNPデータベースにおけるrs番号によって、本発明の多型部位の実際のゲノム上 の位置および前後の配列等を容易に知ることができる。 【００７９】 これによって、知ることができない場合であっても、当業者においては、表１４∼４１ に記載される塩基配列および多型部位等に関する情報から、適宜、該多型部位に相当する 実際のゲノム上の位置を知ることは容易である。例えば、公開されているゲノムデータベ ース等と照会することにより、本発明の多型部位のゲノム上の位置を知ることができる。 即ち、配列表に記載の塩基配列とゲノム上の実際の塩基配列との間に若干の塩基配列の相 違がみられた場合であっても、配列表に記載の塩基配列を基にゲノム配列と相同性検索等 を行うことにより、本発明の多型部位について、実際のゲノム上の位置を正確に知ること 20 が可能である。また、ゲノム上の位置が特定できない場合でも、本明細書に記載の配列表 および多型部位の情報から本発明に記載する検査を行うことは容易である。 【００８０】 また、ゲノムDNAは、通常、互いに相補的な二本鎖DNA構造を有している。従って、本明 細書においては、便宜的に一方の鎖におけるDNA配列を示した場合であっても、当然の如 く、当該配列（塩基）に相補的な配列も開示したものと解釈される。当業者にとって、一 方のDNA配列（塩基）が判れば、該配列（塩基）に相補的な配列（塩基）は自明である。 【００８１】 また本発明の好ましい態様においては、本発明の表１４∼４１に記載したいずれかの塩 基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位であって、 30 『SNPの種類』の欄に記載の多型部位が『有効SNP』と記載された欄の塩基種（ホモまたは ヘテロ）である場合に、TNF阻害薬による関節リウマチ治療の有効性の有無、および／ま たは副作用が起こるか否かの検査を行うことができる。 【００８２】 即ち、多型部位の塩基種が上記の『有効SNP』と記載された欄の塩基種であるような、T NF阻害薬治療による有効性・副作用発現がある患者を含むヒトの小集団について、この「 近傍の多型部位」（例えば、上記『SNPの種類』の欄に記載の多型部位）における塩基種 を予め決定する。 【００８３】 次いで、この「近傍の多型部位」について被検者における塩基種を決定し、予め決定さ 40 れた前記塩基種と比較することにより、TNF阻害薬治療による有効性・副作用発現が起こ るか否かの検査を行うことができる。 【００８４】 予め決定された塩基種と同一の塩基種である場合に、被検者はTNF阻害薬による関節リ ウマチ治療が有効である、および／または副作用が起こると判定される。本発明の検査方 法により、被検者においてTNF阻害薬治療の有効性および／または副作用発現が起こるか 否かを判定することができ、TNF阻害薬を投与することによる関節リウマチの治療方針の 決定や、投与薬剤の決定等に利用することができる。 【００８５】 以上のように、本発明により、ＴNF阻害薬による関節リウマチ治療における有効性およ 50 (16) JP 2010-88432 A 2010.4.22 び／または副作用発現に関連する遺伝子上の領域が明らかになったことにより、当業者に 過度の負担を強いることなく、該有効性の有無および／または副作用発現が起こるか否か について検査を行うことができる。 【００８６】 本発明の多型部位における塩基種の決定は、当業者においては種々の方法によって行う ことができる。一例を示せば、本発明の多型部位を含むDNAの塩基配列を直接決定するこ とによって行うことができる。 【００８７】 本発明の検査方法に供する被検試料は、通常、予め被検者から取得された生体試料であ ることが好ましい。生体試料としては、例えばDNA試料を挙げることができる。本発明に 10 おけるDNA試料は、例えば被検者の血液、皮膚、口腔粘膜、手術により採取あるいは切除 した組織または細胞、検査等の目的で採取された体液等から抽出した染色体DNA、あるい はRNAを基に調製することができる。 【００８８】 即ち本発明は、通常、被検者由来の生体試料（予め被検者から取得された生体試料）を 被検試料として検査に供する方法である。即ち、本発明は被検者から生体試料を単離また は取得する工程を、検査における1つの工程として含みうる。 【００８９】 当業者においては、公知の技術を用いて、適宜、生体試料の調製を行うことができる。 例えば、DNA試料は、本発明の多型部位を含むDNAにハイブリダイズするプライマーを用い 20 て、染色体DNA、あるいはRNAを鋳型としたPCR等によって調製することができる。 【００９０】 本方法においては、次いで、単離したDNAの塩基配列を決定する。単離したDNAの塩基配 列の決定は、当業者においては、DNAシークエンサー等を用いて容易に実施することがで きる。 【００９１】 本発明の多型部位は、通常、その部位の塩基種のバリエーションが既に明らかになって いる。本発明における「塩基種の決定」とは、必ずしもその多型部位についてＡ、Ｇ、Ｔ 、Ｃのいずれかの塩基種であるかを判別することを意味するものではない。例えば、ある 多型部位について塩基種のバリエーションがＡまたはＧであることが判明している場合に 30 は、その部位の塩基種が「Ａでない」または「Ｇでない」ことが判明すれば充分である。 【００９２】 予め塩基のバリエーションが明らかにされている多型部位について、その塩基種を決定 するための様々な方法が公知である。本発明の塩基種の決定方法は、特に限定されない。 例えば、PCR法を応用した解析方法として、TaqMan PCR法、AcycloPrime法、およびMALDITOF/MS法等が実用化されている。またPCRに依存しない塩基種の決定法としてInvader法や RCA法が知られている。更にDNAアレイを使って塩基種を決定することもできる。以下にこ れらの方法について簡単に述べる。ここに述べた方法は、いずれも本発明における多型部 位の塩基種の決定に応用できる。 【００９３】 40 ［TaqMan PCR法］ TaqMan PCR法の原理は次のとおりである。TaqMan PCR法は、アリルを含む領域を増幅す ることができるプライマーセットと、TaqManプローブを利用した解析方法である。TaqMan プローブは、このプライマーセットによって増幅されるアリルを含む領域にハイブリダイ ズするように設計される。 【００９４】 TaqManプローブのTmに近い条件で標的塩基配列にハイブリダイズさせれば、１塩基の相 違によってTaqManプローブのハイブリダイズ効率は著しく低下する。TaqManプローブの存 在下でPCR法を行うと、プライマーカーらの伸長反応は、いずれハイブリダイズしたTaqMa nプローブに到達する。このときDNAポリメラーゼの5'-3'エキソヌクレアーゼ活性によっ 50 (17) JP 2010-88432 A 2010.4.22 て、TaqManプローブはその5'末端から分解される。TaqManプローブをレポーター色素とク エンチャーで標識しておけば、TaqManプローブの分解を、蛍光シグナルの変化として追跡 することができる。つまり、TaqManプローブの分解が起きれば、レポーター色素が遊離し てクエンチャーとの距離が離れることによって蛍光シグナルが生成する。１塩基の相違の ためにTaqManプローブのハイブリダイズが低下すればTaqManプローブの分解が進まず蛍光 シグナルは生成されない。 【００９５】 多型に対応するTaqManプローブをデザインし、更に各プローブの分解によって異なるシ グナルが生成されるようにすれば、同時に塩基種の判定を行うこともできる。例えば、レ ポーター色素として、あるアリルのアリルＡのTaqManプローブに6-carboxy-fluorescein( 10 FAM)を、アリルＢのプローブにVICを用いる。プローブが分解されない状態では、クエン チャーによってレポーター色素の蛍光シグナル生成は抑制されている。各プローブが対応 するアリルにハイブリダイズすれば、ハイブリダイズに応じた蛍光シグナルが観察される 。すなわち、FAMまたはVICのいずれかのシグナルが他方よりも強い場合には、アリルＡま たはアリルＢのホモであることが判明する。他方、アリルをヘテロで有する場合には、両 者のシグナルがほぼ同じレベルで検出されることになる。TaqMan PCR法の利用によって、 ゲル上での分離のような時間のかかる工程無しで、ゲノムを解析対象としてPCRと塩基種 の決定を同時に行うことができる。そのため、TaqMan PCR法は、多くの被検者についての 塩基種を決定できる方法として有用である。 【００９６】 20 ［AcycloPrime法］ PCR法を利用した塩基種を決定する方法として、AcycloPrime法も実用化されている。Ac ycloPrime法では、ゲノム増幅用のプライマー１組と、多型検出用の１つのプライマーを 用いる。まず、ゲノムの多型部位を含む領域をPCRで増幅する。この工程は、通常のゲノ ムPCRと同じである。次に、得られたPCR産物に対して、SNPs検出用のプライマーをアニー ルさせ、伸長反応を行う。SNPs検出用のプライマーは、検出対象となっている多型部位に 隣接する領域にアニールするようにデザインされている。 【００９７】 このとき、伸長反応のためのヌクレオチド基質として、蛍光偏光色素でラベルし、かつ 3'-OHをブロックしたヌクレオチド誘導体（ターミネータ）を用いる。その結果、多型部 30 位に相当する位置の塩基に相補的な塩基が１塩基だけ取りこまれて伸長反応が停止する。 ヌクレオチド誘導体のプライマーへの取りこみは、分子量の増大による蛍光偏光(Fluores cence polarization;FP)の増加によって検出することができる。蛍光偏光色素に波長の異 なる２種類のラベルを用いれば、特定のSNPsが２種類の塩基のうちのいずれであるのかを 特定することができる。蛍光偏光のレベルは定量することができるので、１度の解析でア リルがホモかヘテロかを判定することもできる。 【００９８】 ［MALDI-TOF/MS法］ PCR産物をMALDI-TOF/MSで解析することによって塩基種の決定を行うこともできる。MAL DI-TOF/MSは、分子量をきわめて正確に知ることができるため、タンパク質のアミノ酸配 40 列や、DNAの塩基配列のわずかな相違を明瞭に識別することができる解析手法として様々 な分野で利用されている。MALDI-TOF/MSによる塩基種の決定のためには、まず解析対象で あるアリルを含む領域をPCRで増幅する。次いで増幅産物を単離してMALDI-TOF/MSによっ てその分子量を測定する。アリルの塩基配列は予めわかっているので、分子量に基づいて 増幅産物の塩基配列は一義的に決定される。 【００９９】 MALDI-TOF/MSを利用した塩基種の決定には、PCR産物の分離工程などが必要となる。し かし標識プライマーや標識プローブを使わないで、正確な塩基種の決定が期待できる。ま た複数の場所の多型の同時検出にも応用することができる。 【０１００】 50 (18) JP 2010-88432 A 2010.4.22 ［IIs型制限酵素を利用したSNPs特異的な標識方法］ PCR法を利用した更に高速な塩基種の決定が可能な方法も報告されている。例えば、IIs 型制限酵素を利用して多型部位の塩基種の決定が行われている。この方法においては、PC Rにあたり、IIs型制限酵素の認識配列を有するプライマーが用いられる。遺伝子組み換え に利用される一般的な制限酵素（II型）は、特定の塩基配列を認識して、その塩基配列中 の特定部位を切断する。これに対してIIs型の制限酵素は、特定の塩基配列を認識して、 認識塩基配列から離れた部位を切断する。酵素によって、認識配列と切断個所の間の塩基 数は決まっている。従って、この塩基数の分だけ離れた位置にIIs型制限酵素の認識配列 を含むプライマーがアニールするようにすれば、IIs型制限酵素によってちょうど多型部 位で増幅産物を切断することができる。 10 【０１０１】 IIs型制限酵素で切断された増幅産物の末端には、SNPsの塩基を含む付着末端(conhesiv e end)が形成される。ここで、増幅産物の付着末端に対応する塩基配列からなるアダプタ ーをライゲーションする。アダプターは、多型変異に対応する塩基を含む異なる塩基配列 からなり、それぞれ異なる蛍光色素で標識しておくことができる。最終的に、増幅産物は 多型部位の塩基に対応する蛍光色素で標識される。 【０１０２】 前記IIs型制限酵素認識配列を含むプライマーに、捕捉プライマー(capture primer)を 組み合わせてPCR法を行えば、増幅産物は蛍光標識されるとともに、捕捉プライマーを利 用して固相化することができる。例えばビオチン標識プライマーを捕捉プライマーとして 20 用いれば、増幅産物はアビジン結合ビーズに捕捉することができる。こうして捕捉された 増幅産物の蛍光色素を追跡することにより、塩基種を決定することができる。 【０１０３】 ［磁気蛍光ビーズを使った多型部位における塩基種の決定］ 複数のアリルを単一の反応系で並行して解析することができる技術も公知である。複数 のアリルを並行して解析することは、多重化と呼ばれている。一般に蛍光シグナルを利用 したタイピング方法では、多重化のために異なる蛍光波長を有する蛍光成分が必要である 。しかし実際の解析に利用することができる蛍光成分は、それほど多くない。これに対し て、樹脂等に複数種の蛍光成分を混合した場合には、限られた種類の蛍光成分であっても 、相互に識別可能な多様な蛍光シグナルを得ることができる。更に、樹脂中に磁気で吸着 30 される成分を加えれば蛍光を発するとともに、磁気によって分離可能なビーズとすること ができる。このような磁気蛍光ビーズを利用した、多重化多型タイピングが考え出された (バイオサイエンスとバイオインダストリー, Vol.60 No.12, 821-824)。 【０１０４】 磁気蛍光ビーズを利用した多重化多型タイピングにおいては、各アリルの多型部位に相 補的な塩基を末端に有するプローブが磁気蛍光ビーズに固定化される。各アリルにそれぞ れ固有の蛍光シグナルを有する磁気蛍光ビーズが対応するように、両者は組み合わせられ る。一方、磁気蛍光ビーズに固定されたプローブが相補配列にハイブリダイズしたときに 、当該アリル上で隣接する領域に相補的な塩基配列を有する蛍光標識オリゴDNAを調製す る。 40 【０１０５】 アリルを含む領域を非対称PCRによって増幅し、上記の磁気蛍光ビーズ固定化プローブ と蛍光標識オリゴDNAをハイブリダイズさせ、更に両者をライゲーションする。磁気蛍光 ビーズ固定化プローブの末端が、多型部位の塩基に相補的な塩基配列であった場合には効 率的にライゲーションされる。逆にもしも多型のために末端の塩基が異なれば、両者のラ イゲーション効率は低下する。その結果、各磁気蛍光ビーズには、試料が当該磁気蛍光ビ ーズに相補的な塩基種であった場合に限り、蛍光標識オリゴDNAが結合する。 【０１０６】 磁気によって磁気蛍光ビーズを回収し、更に各磁気蛍光ビーズ上の蛍光標識オリゴDNA の存在を検出することにより、塩基種が決定される。磁気蛍光ビーズは、フローサイトメ 50 (19) JP 2010-88432 A 2010.4.22 ーターでビーズ毎に蛍光シグナルを解析できるので、多種類の磁気蛍光ビーズが混合され ていてもシグナルの分離は容易である。つまり、多種類の多型部位について、単一の反応 容器で並行して解析する「多重化」が達成される。 【０１０７】 ［Invader法］ PCR法に依存しないジェノタイピングのための方法も実用化されている。例えば、Invad er法では、アリルプローブ、インベーダープローブ、およびFRETプローブの３種類のオリ ゴヌクレオチドと、cleavaseと呼ばれる特殊なヌクレアーゼのみで、塩基種の決定を実現 している。これらのプローブのうち標識が必要なのはFRETプローブのみである。 【０１０８】 10 アリルプローブは、検出すべきアリルに隣接する領域にハイブリダイズするようにデザ インされる。アリルプローブの5'側には、ハイブリダイズに無関係な塩基配列からなるフ ラップが連結されている。アリルプローブは多型部位の3'側にハイブリダイズし、多型部 位の上でフラップに連結する構造を有する。 【０１０９】 一方インベーダープローブは、多型部位の5'側にハイブリダイズする塩基配列からなっ ている。インベーダープローブの塩基配列は、ハイブリダイズによって3'末端が多型部位 に相当するようにデザインされている。インベーダープローブにおける多型部位に相当す る位置の塩基は任意で良い。つまり、多型部位を挟んでインベーダープローブとアリルプ ローブとが隣接してハイブリダイズするように両者の塩基配列はデザインされている。 20 【０１１０】 多型部位がアリルプローブの塩基配列に相補的な塩基であった場合には、インベーダー プローブとアリルプローブの両者がアリルにハイブリダイズすると、アリルプローブの多 型部位に相当する塩基にインベーダープローブが侵入(invasion)した構造が形成される。 cleavaseは、このようにして形成された侵入構造を形成したオリゴヌクレオチドのうち、 侵入された側の鎖を切断する。切断は侵入構造の上で起きるので、結果としてアリルプロ ーブのフラップが切り離されることになる。一方、もしも多型部位の塩基がアリルプロー ブの塩基に相補的でなかった場合には、多型部位におけるインベーダープローブとアリル プローブの競合は無く、侵入構造は形成されない。したがってcleavaseによるフラップの 切断が起こらない。 30 【０１１１】 FRETプローブは、こうして切り離されたフラップを検出するためのプローブである。FR ETプローブは5'末端側に自己相補配列を有し、3'末端側に１本鎖部分が配置されたヘアピ ンループを構成している。FRETプローブの3'末端側に配置された１本鎖部分は、フラップ に相補的な塩基配列からなっていて、ここにフラップがハイブリダイズすることができる 。フラップがFRETプローブにハイブリダイズすると、FRETプローブの自己相補配列の5'末 端部分にフラップの3'末端が侵入した構造が形成されるように両者の塩基配列がデザイン されている。cleavaseは侵入構造を認識して切断する。FRETプローブのcleavaseによって 切断される部分を挟んで、TaqMan PCRと同様のレポーター色素とクエンチャーで標識して おけば、FRETプローブの切断を蛍光シグナルの変化として検知することができる。 40 【０１１２】 なお、理論的には、フラップは切断されない状態でもFRETプローブにハイブリダイズす るはずである。しかし実際には、切断されたフラップとアリルプローブの状態で存在して いるフラップとでは、FRETに対する結合効率に大きな差がある。そのため、FRETプローブ を利用して、切断されたフラップを特異的に検出することは可能である。 【０１１３】 Invader法に基づいて塩基種を決定するためには、アリルＡとアリルＢのそれぞれに相 補的な塩基配列を含む、２種類のアリルプローブを用意すれば良い。このとき両者のフラ ップの塩基配列は異なる塩基配列とする。フラップを検出するためのFRETプローブも２種 類を用意し、それぞれのレポーター色素を識別可能なものとしておけば、TaqMan PCR法と 50 (20) JP 2010-88432 A 2010.4.22 同様の考え方によって、塩基種を決定することができる。 【０１１４】 Invader法の利点は、標識の必要なオリゴヌクレオチドがFRETプローブのみであること である。FRETプローブは検出対象の塩基配列とは無関係に、同一のオリゴヌクレオチドを 利用することができる。従って、大量生産が可能である。一方アリルプローブとインベー ダープローブは標識する必要が無いので、結局、ジェノタイピングのための試薬を安価に 製造することができる。 【０１１５】 ［RCA法］ PCR法に依存しない塩基種の決定方法として、RCA法を挙げることができる。鎖置換作用 10 を有するDNAポリメラーゼが、環状の１本鎖DNAを鋳型として、長い相補鎖を合成する反応 に基づくDNAの増幅方法が、Rolling Circle Amplification(RCA)法である(Lizardri PM e t al.,Nature Genetics 19, 225, 1998)。RCA法においては、環状DNAにアニールして相補 鎖合成を開始するプライマーと、このプライマーによって生成する長い相補鎖にアニール する第２のプライマーを利用して、増幅反応を構成している。 【０１１６】 RCA法には、鎖置換作用を有するDNAポリメラーゼが利用されている。そのため、相補鎖 合成によって２本鎖となった部分は、より5'側にアニールした別のプライマーカーら開始 した相補鎖合成反応によって置換される。例えば、環状DNAを鋳型とする相補鎖合成反応 は、１周分では終了しない。先に合成した相補鎖を置換しながら相補鎖合成は継続し、長 20 い１本鎖DNAが生成される。一方、環状DNAを鋳型として生成した長い１本鎖DNAには、第 ２のプライマーがアニールして相補鎖合成が開始する。RCA法において生成される１本鎖D NAは、環状のDNAを鋳型としていることから、その塩基配列は同じ塩基配列の繰り返しで ある。従って、長い１本鎖の連続的な生成は、第２のプライマーの連続的なアニールをも たらす。その結果、変性工程を経ることなく、プライマーがアニールすることができる１ 本鎖部分が連続的に生成される。こうして、DNAの増幅が達成される。 【０１１７】 RCA法に必要な環状１本鎖DNAが多型部位の塩基種に応じて生成されれば、RCA法を利用 して塩基種の決定をすることができる。そのために、直鎖状で１本鎖のパドロックプロー ブが利用される。パドロックプローブは、5'末端と3'末端に検出すべき多型部位の両側に 30 相補的な塩基配列を有している。これらの塩基配列は、バックボーンと呼ばれる特殊な塩 基配列からなる部分で連結されている。多型部位がパドロックプローブの末端に相補的な 塩基配列であれば、アリルにハイブリダイズしたパドロックプローブの末端をDNAリガー ゼによってライゲーションすることができる。その結果、直鎖状のパドロックプローブが 環状化され、RCA法の反応がトリガーされる。DNAリガーゼの反応は、ライゲーションすべ き末端部分が完全に相補的でない場合には反応効率が著しく低下する。従って、ライゲー ションの有無をRCA法で確認することによって、多型部位の塩基種の決定が可能である。 【０１１８】 RCA法は、DNAを増幅することはできるが、そのままではシグナルを生成しない。また増 幅の有無のみを指標とするのでは、アリル毎に反応を行わなければ、通常、塩基種を決定 40 することができない。これらの点を塩基種の決定のために改良した方法が公知である。例 えば、モレキュラービーコンを利用して、RCA法に基づいて１チューブで塩基種の決定を 行うことができる。モレキュラービーコンは、TaqMan法と同様に、蛍光色素とクエンチャ ーを利用したシグナル生成用プローブである。モレキュラービーコンの5'末端と3'末端は 相補的な塩基配列で構成されており、単独ではヘアピン構造を形成する。両端付近を蛍光 色素とクエンチャーで標識しておけば、ヘアピン構造を形成している状態では蛍光シグナ ルが検出できない。モレキュラービーコンの一部を、RCA法の増幅産物に相補的な塩基配 列としておけば、モレキュラービーコンはRCA法の増幅産物にハイブリダイズする。ハイ ブリダイズによってヘアピン構造が解消されるため、蛍光シグナルが生成される。 【０１１９】 50 (21) JP 2010-88432 A 2010.4.22 モレキュラービーコンの利点は、パドロックプローブのバックボーン部分の塩基配列を 利用することによって、検出対象とは無関係にモレキュラービーコンの塩基配列を共通に できる点である。アリル毎にバックボーンの塩基配列を変え、蛍光波長が異なる２種類の モレキュラービーコンを組み合わせれば、１チューブで塩基種の決定が可能である。蛍光 標識プローブの合成コストは高いので、測定対象に関わらず共通のプローブを利用できる ことは、経済的なメリットである。 【０１２０】 これらの方法はいずれも多量のサンプルを高速にジェノタイピングするために開発され た方法である。MALDI-TOF/MSを除けば、通常、いずれの方法にも何らかの形で標識プロー ブなどを用意する必要がある。これに対して、標識プローブなどに頼らない塩基種決定法 10 も古くから行われている。このような方法の一つとして、例えば、制限酵素断片長多型（ Restriction Fragment Length Polymorphism／RFLP）を利用した方法やPCR-RFLP法等が挙 げられる。 【０１２１】 RFLPは、制限酵素の認識部位の変異、あるいは制限酵素処理によって生じるDNA断片内 における塩基の挿入または欠失が、制限酵素処理後に生じる断片の大きさの変化として検 出できることを利用している。検出対象となる多型を含む塩基配列を認識する制限酵素が 存在すれば、RFLPの原理によって多型部位の塩基を知ることができる。 【０１２２】 標識プローブを必要としない方法として、DNAの二次構造の変化を指標として塩基の違 20 いを検出する方法も公知である。PCR-SSCPでは、１本鎖DNAの二次構造がその塩基配列の 相違を反映することを利用している(Cloning and polymerase chain reaction-single-st rand conformation polymorphism analysis of anonymous Alu repeats on chromosome 1 1. Genomics. 1992 Jan 1; 12(1): 139-146.、Detection of p53 gene mutations in hum an brain tumors by single-strand conformation polymorphism analysis of polymeras e chain reaction products. Oncogene. 1991 Aug 1; 6(8): 1313-1318.、Multiple fluo rescence-based PCR-SSCP analysis with postlabeling.、PCR Methods Appl. 1995 Apr 1; 4(5): 275-282.)。PCR-SSCP法は、PCR産物を１本鎖DNAに解離させ、非変性ゲル上で分 離する工程により実施される。ゲル上の移動度は、１本鎖DNAの二次構造によって変動す るので、もしも多型部位における塩基の相違があれば、移動度の違いとして検出すること 30 ができる。 【０１２３】 その他、標識プローブを必要としない方法として、例えば、変性剤濃度勾配ゲル（dena turant gradient gel electrophoresis： DGGE法）等を例示することができる。DGGE法は 、変性剤の濃度勾配のあるポリアクリルアミドゲル中で、DNA断片の混合物を泳動し、そ れぞれの不安定性の違いによってDNA断片を分離する方法である。ミスマッチのある不安 定なDNA断片が、ゲル中のある変性剤濃度の部分まで移動すると、ミスマッチ周辺のDNA配 列はその不安定さのために、部分的に１本鎖へと解離する。部分的に解離したDNA断片の 移動度は、非常に遅くなり、解離部分のない完全な二本鎖DNAの移動度と差がつくことか ら、両者を分離することができる。 40 【０１２４】 具体的には、まずPCR法等によって多型部位を含む領域を増幅する。増幅産物に、塩基 配列がわかっているプローブDNAをハイブリダイズさせて２本鎖とする。これを尿素など の変性剤の濃度が移動するに従って徐々に高くなっているポリアクリルアミドゲル中で電 気泳動し、対照と比較する。プローブDNAとのハイブリダイズによってミスマッチを生じ たDNA断片では、より低い変性剤濃度位置でDNA断片が一本鎖になり、極端に移動速度が遅 くなる。こうして生じた移動度の差を検出することによりミスマッチの有無を検出するこ とができる。 【０１２５】 更にDNAアレイを使って塩基種を決定することもできる（細胞工学別冊「DNAマイクロア 50 (22) JP 2010-88432 A 2010.4.22 レイと最新PCR法」,秀潤社,2000.4/20発行,pp97-103「オリゴDNAチップによるSNPの解析 」,梶江慎一）。DNAアレイは、同一平面上に配置した多数のプローブに対してサンプルDN A（あるいはRNA）をハイブリダイズさせ、当該平面をスキャンすることによって、各プロ ーブに対するハイブリダイズが検出される。多くのプローブに対する反応を同時に観察す ることができることから、例えば、多数の多型部位について同時に解析するには、DNAア レイは有用である。 【０１２６】 一般にDNAアレイは、高密度に基板にプリントされた何千ものヌクレオチドで構成され ている。通常これらのDNAは非透過性(non- porous)の基板の表層にプリントされる。基板 の表層は、一般的にはガラスであるが、透過性(porous)の膜、例えばニトロセルロースメ 10 ンブレムを使用することもできる。 【０１２７】 本発明において、ヌクレオチドの固定（アレイ）方法として、Affymetrix社開発による オリゴヌクレオチドを基本としたアレイが例示できる。オリゴヌクレオチドのアレイにお いて、オリゴヌクレオチドは通常インビトロ(in vitro)で合成される。例えば、photolit hographicの技術（Affymetrix社）、および化学物質を固定させるためのインクジェット( Rosetta Inpharmatics社)技術等によるオリゴヌクレオチドのインサイチュ合成法が既に 知られており、いずれの技術も本発明の基板の作製に利用することができる。 【０１２８】 オリゴヌクレオチドは、検出すべきSNPsを含む領域に相補的な塩基配列で構成される。 20 基板に結合させるヌクレオチドプローブの長さは、オリゴヌクレオチドを固定する場合は 、通常10∼100ベースであり、好ましくは10∼50ベースであり、さらに好ましくは15∼25 ベースである。更に、一般にDNAアレイ法においては、クロスハイブリダイゼーション（ 非特異的ハイブリダイゼーション）による誤差を避けるために、ミスマッチ(MM)プローブ が用いられる。ミスマッチプローブは、標的塩基配列と完全に相補的な塩基配列からなる オリゴヌクレオチドとのペアを構成している。ミスマッチプローブに対して、完全に相補 的な塩基配列からなるオリゴヌクレオチドはパーフェクトマッチ（PM）プローブと呼ばれ る。データ解析の過程で、ミスマッチプローブで観察されたシグナルを消去することによ って、クロスハイブリダイゼーションの影響を小さくすることができる。 【０１２９】 30 DNAアレイ法によるジェノタイピングのための試料は、被検者から採取された生物学的 試料をもとに当業者に周知の方法で調製することができる。生物学的試料は特に限定され ない。例えば被検者の血液、末梢血白血球、皮膚、口腔粘膜等の組織または細胞、涙、唾 液、尿、糞便または毛髪から抽出した染色体DNAから、DNA試料を調製することができる。 判定すべき多型部位を含む領域を増幅するためのプライマーを用いて、染色体DNAの特定 の領域が増幅される。このとき、マルチプレックスPCR法によって複数の領域を同時に増 幅することができる。マルチプレックスPCR法とは、複数組のプライマーセットを、同じ 反応液中で用いるPCR法である。複数の多型部位を解析するときには、マルチプレックスP CR法が有用である。 【０１３０】 40 一般にDNAアレイ法においては、PCR法によってDNA試料を増幅するとともに、増幅産物 が標識される。増幅産物の標識には、標識を付したプライマーが利用される。例えば、ま ず多型部位を含む領域に特異的なプライマーセットによるPCR法でゲノムDNAを増幅する。 次に、ビオチンラベルしたプライマーを使ったラベリングPCR法によって、ビオチンラベ ルされたDNAを合成する。こうして合成されたビオチンラベルDNAを、チップ上のオリゴヌ クレオチドプローブにハイブリダイズさせる。ハイブリダイゼーションの反応液および反 応条件は、基板に固定するヌクレオチドプローブの長さや反応温度等の条件に応じて、適 宜調整することができる。当業者は、適切なハイブリダイゼーションの条件をデザインす ることができる。ハイブリダイズしたDNAを検出するために、蛍光色素で標識したアビジ ンが添加される。アレイをスキャナで解析し、蛍光を指標としてハイブリダイズの有無を 50 (23) JP 2010-88432 A 2010.4.22 確認する。 【０１３１】 上記方法をより具体的に示せば、被検者から調製した本発明の多型部位を含むDNA、お よびヌクレオチドプローブが固定された固相、を取得した後、次いで、該DNAと該固相を 接触させる。さらに、固相に固定されたヌクレオチドプローブにハイブリダイズしたDNA を検出することにより、本発明の多型部位の塩基種を決定する。 【０１３２】 本発明において「固相」とは、ヌクレオチドを固定することが可能な材料を意味する。 本発明の固相は、ヌクレオチドを固定することが可能であれば特に制限はないが、具体的 には、マイクロプレートウェル、プラスチックビーズ、磁性粒子、基板などを含む固相等 10 を例示することができる。本発明の「固相」としては、一般にDNAアレイ技術で使用され る基板を好適に用いることができる。本発明において「基板」とは、ヌクレオチドを固定 することが可能な板状の材料を意味する。また、本発明においてヌクレオチドには、オリ ゴヌクレオチドおよびポリヌクレオチドが含まれる。 【０１３３】 上記の方法以外にも、特定部位の塩基を検出するために、アリル特異的オリゴヌクレオ チド（Allele Specific Oligonucleotide／ASO）ハイブリダイゼーション法が利用できる 。アリル特異的オリゴヌクレオチド(ASO)は、検出すべき多型部位が存在する領域にハイ ブリダイズする塩基配列で構成される。ASOを試料DNAにハイブリダイズさせるとき、多型 によって多型部位にミスマッチが生じるとハイブリッド形成の効率が低下する。ミスマッ 20 チは、サザンブロット法や、特殊な蛍光試薬がハイブリッドのギャップにインターカレー ションすることにより消光する性質を利用した方法等によって検出することができる。ま た、リボヌクレアーゼAミスマッチ切断法によって、ミスマッチを検出することもできる 。 【０１３４】 上記オリゴヌクレオチドのうち、表１４∼４１に記載したいずれかの塩基配列、該塩基 配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位であって、『SNPの種類』 の欄に記載の多型部位を含むDNAにハイブリダイズし、少なくとも15ヌクレオチドの鎖長 を有するオリゴヌクレオチドは、TNF阻害薬による関節リウマチ治療の有効性の有無、お よび／または副作用が起こるか否かを検出するための試薬（検査薬）として利用できる。 30 これは遺伝子発現を指標とする検査、または遺伝子多型を指標とする検査に使用される。 【０１３５】 該オリゴヌクレオチドは、本発明の上記表１４∼４１に記載したいずれかの塩基配列、 該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位であって、『SNPの 種類』の欄に記載の多型部位を含むDNAに特異的にハイブリダイズするものである。 【０１３６】 ここで「特異的にハイブリダイズする」とは、通常のハイブリダイゼーション条件下、 好ましくはストリンジェントなハイブリダイゼーション条件下（例えば、サムブルックら ,Molecular Cloning,Cold Spring Harbour Laboratory Press,New York,USA,第２版1989 に記載の条件）において、他のタンパク質をコードするDNAとクロスハイブリダイゼーシ 40 ョンを有意に生じないことを意味する。特異的なハイブリダイズが可能であれば、該オリ ゴヌクレオチドは、該遺伝子または該遺伝子の近傍DNA領域における塩基配列に対し、完 全に相補的である必要はない。 【０１３７】 該オリゴヌクレオチドは、上記本発明の検査方法におけるプローブやプライマーとして 用いることができる。該オリゴヌクレオチドをプライマーとして用いる場合、その長さは 、通常15bp∼100bpであり、好ましくは17bp∼30bpである。プライマーは、本発明の表１ ４∼４１に記載したいずれかの塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子 の近傍DNA領域上の部位であって、『SNPの種類』の欄に記載の多型部位を含むDNAの少な くとも一部を増幅しうるものであれば、特に制限されない。 50 (24) JP 2010-88432 A 2010.4.22 【０１３８】 本発明は、本発明の多型部位を含む領域を増幅するためのプライマー、および多型部位 を含むDNA領域にハイブリダイズするプローブを提供する。 【０１３９】 本発明において、多型部位を含む領域を増幅するためのプライマーには、多型部位を含 むDNAを鋳型として、多型部位に向かって相補鎖合成を開始することができるプライマー も含まれる。該プライマーは、多型部位を含むDNAにおける、多型部位の3'側に複製開始 点を与えるためのプライマーと表現することもできる。プライマーがハイブリダイズする 領域と多型部位との間隔は任意である。両者の間隔は、多型部位の塩基の解析手法に応じ て、好適な塩基数を選択することができる。たとえば、DNAチップによる解析のためのプ 10 ライマーであれば、多型部位を含む領域として、２０∼５００、通常５０∼２００塩基の 長さの増幅産物が得られるようにプライマーをデザインすることができる。当業者におい ては、多型部位を含む周辺DNA領域についての塩基配列情報を基に、解析手法に応じたプ ライマーをデザインすることができる。本発明のプライマーを構成する塩基配列は、ゲノ ムの塩基配列に対して完全に相補的な塩基配列のみならず、適宜改変することができる。 【０１４０】 本発明のプライマーには、ゲノムの塩基配列に相補的な塩基配列に加え、任意の塩基配 列を付加することができる。例えば、IIs型の制限酵素を利用した多型の解析方法のため のプライマーにおいては、IIs型制限酵素の認識配列を付加したプライマーが利用される 。このような、塩基配列を修飾したプライマーは、本発明のプライマーに含まれる。更に 20 、本発明のプライマーは、修飾することができる。例えば、蛍光物質や、ビオチンまたは ジゴキシンのような結合親和性物質で標識したプライマーが各種のジェノタイピング方法 において利用される。これらの修飾を有するプライマーも本発明に含まれる。 【０１４１】 一方本発明において、多型部位を含む領域にハイブリダイズするプローブとは、多型部 位を含む領域の塩基配列を有するポリヌクレオチドとハイブリダイズすることができるプ ローブを言う。より具体的には、プローブの塩基配列中に多型部位を含むプローブは本発 明のプローブとして好ましい。あるいは、多型部位における塩基の解析方法によっては、 プローブの末端が多型部位に隣接する塩基に対応するように、デザインされる場合もある 。従って、プローブ自身の塩基配列には多型部位が含まれないが、多型部位に隣接する領 30 域に相補的な塩基配列を含むプローブも、本発明における望ましいプローブとして示すこ とができる。 【０１４２】 言いかえれば、ゲノムDNA上の本発明の多型部位、または多型部位に隣接する部位にハ イブリダイズすることができるプローブは、本発明のプローブとして好ましい。本発明の プローブには、プライマーと同様に、塩基配列の改変、塩基配列の付加、あるいは修飾が 許される。例えば、Invader法に用いるプローブは、フラップを構成するゲノムとは無関 係な塩基配列が付加される。このようなプローブも、多型部位を含む領域にハイブリダイ ズする限り、本発明のプローブに含まれる。本発明のプローブを構成する塩基配列は、ゲ ノムにおける本発明の多型部位の周辺DNA領域の塩基配列をもとに、解析方法に応じてデ 40 ザインすることができる。 【０１４３】 本発明のプライマーまたはプローブは、それを構成する塩基配列をもとに、任意の方法 によって合成することができる。本発明のプライマーまたはプローブの、ゲノムDNAに相 補的な塩基配列の長さは、通常１５∼１００、一般に１５∼５０、通常１５∼３０である 。与えられた塩基配列に基づいて、当該塩基配列を有するオリゴヌクレオチドを合成する 手法は公知である。更に、オリゴヌクレオチドの合成において、蛍光色素やビオチンなど で修飾されたヌクレオチド誘導体を利用して、オリゴヌクレオチドに任意の修飾を導入す ることもできる。あるいは、合成されたオリゴヌクレオチドに、蛍光色素などを結合する 方法も公知である。 50 (25) JP 2010-88432 A 2010.4.22 【０１４４】 本発明のプローブの具体的な例としては、それぞれ表１４∼４１に記載したいずれかの 塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位であって 、『SNPの種類』の欄に記載の多型部位に記載のいずれかの多型部位を含む領域にハイブ リダイズするプローブであって、少なくとも15ヌクレオチドの鎖長を有するプローブが挙 げられる。 【０１４５】 本発明はまた、本発明のTNF阻害薬による関節リウマチ治療の有効性の有無、および／ または副作用が起こるか否かの検出方法に使用するための試薬（検査薬）を提供する。本 発明の試薬は、前記本発明のプライマーおよび／またはプローブを含む。TNF阻害薬治療 10 による有効性・副作用発現が起こるか否かの検査においては表１４∼４１に記載したいず れかの塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位で あって、『SNPの種類』の欄に記載の多型部位を含むDNAを増幅するためのプライマーおよ び／またはプローブを用いる。 【０１４６】 本発明の試薬には、塩基種の決定方法に応じて、各種の酵素、酵素基質、および緩衝液 などを組み合わせることができる。酵素としては、DNAポリメラーゼ、DNAリガーゼ、ある いはIIs制限酵素などの、上記の塩基種決定方法として例示した各種の解析方法に必要な 酵素を示すことができる。緩衝液は、これらの解析に用いる酵素の活性の維持に好適な緩 衝液が、適宜選択される。更に、酵素基質としては、例えば、相補鎖合成用の基質等が用 20 いられる。 【０１４７】 更に本発明の試薬には、多型部位における塩基が明らかな対照を添付することができる 。対照は、予め多型部位の塩基種が明らかなゲノム、あるいはゲノムの断片を用いること ができる。ゲノムは、細胞から抽出されたものでもよいし、細胞あるいは細胞の分画を用 いることもできる。細胞を対照として用いれば、対照の結果によってゲノムDNAの抽出操 作が正しく行われたことを証明することができる。あるいは、多型部位を含む塩基配列か らなるDNAを対照として用いることもできる。具体的には、本発明の多型部位における塩 基種が明らかにされたゲノム由来のDNAを含むYACベクターやBACベクターは、対照として 有用である。あるいは多型部位に相当する数百ベースのみを切り出して挿入したベクター 30 を対照として用いることもできる。 【０１４８】 さらに、本発明における試薬の別の態様は、本発明の表１４∼４１に記載したいずれか の塩基配列、該塩基配列の近傍DNA領域、遺伝子、該遺伝子の近傍DNA領域上の部位であっ て、『SNPの種類』の欄に記載の多型部位を含むDNAとハイブリダイズするヌクレオチドプ ローブが固定された固相からなる、TNF阻害薬による関節リウマチ治療の有効性の有無、 および／または副作用が起こるか否かを検査するための試薬である。 これらは本発明の多型部位を指標とする検査に使用される。これらの調製方法に関して は、上述の通りである。 【０１４９】 40 また本発明は、被検者（被検者由来の生体試料）における表１４∼４１に記載したいず れかの塩基配列または遺伝子の発現量を指標として、TNF阻害薬治療による有効性・副作 用発現が起こるか否かの判定を行うことも可能である。即ち本発明は、被検者における表 １４∼４１に記載したいずれかの塩基配列または遺伝子の発現量が対照と比較して低下し ている場合に、被検者はTNF阻害薬治療による有効性・副作用発現を発症するものと判定 される、TNF阻害薬治療による有効性・副作用発現が起こるか否かを検査する方法を提供 する。 【０１５０】 上記方法においては、通常、被検者由来の生体試料を被検試料とする。該被検試料にお ける該遺伝子の発現量の測定は、当業者においては公知の技術を用いて適宜実施すること 50 (26) JP 2010-88432 A 2010.4.22 が可能である。なお、上記「対照」とは、通常、健常者由来の生体試料における該遺伝子 の発現量を指す。なお、本発明における表１４∼４１に記載したいずれかの塩基配列また は遺伝子の発現とは、該遺伝子から転写されるmRNAの発現、または該遺伝子によってコー ドされるタンパク質の発現の両方を意味するものである。 【実施例】 【０１５１】 ＜研究集団＞ 松原メイフラワー病院（日本・兵庫県）の外来に通院、または入院中の関節リウマチと 診断された患者のうち、遺伝子型決定に関するインフォームドコンセントが書面で得られ た後、最終的にゲノムDNAが入手可能であった患者208人を一次集団として解析を行った。 10 佐川昭リウマチクリニック（日本・北海道）・医療法人井上病院（日本・群馬県）・松野 リウマチ整形外科（日本・富山県）・生野リウマチ 整形外科クリニック（日本・福岡県 ）泉原リウマチ・内科クリニック（日本・鹿児島県）の外来に通院、または入院中の関節 リウマチと診断された患者のうち、遺伝子型決定に関するインフォームドコンセントが書 面で得られた後、最終的にゲノムDNAが入手可能であった患者206人を二次集団として解析 を行った。これらのリウマチ患者は米国リウマチ学会（American College of Rheumatolo gy）により規定された基準に従い診断された。研究プロトコールは、松原メイフラワー病 院倫理委員会／ヒュービットジェノミクス株式会社倫理審査委員会の承認を受けており、 インフォームドコンセントの書面を、全患者から本調査に参加する前に得た。 【０１５２】 20 １．各薬剤対象患者の選別 （インフリキシマブ） 以下の（１）から（３）の条件をすべて満たすインフリキシマブ（商品名：レミケード ）未投与の患者対象とした。 （１）メトトレキサート製剤（商品名：リウマトレックス）を6 mg/週以上の用量で3ヶ月 以上継続して投与してもコントロール不良の関節リウマチ患者（以下の3項目を判定基準 とした） ・疼痛関節≧6個 ・腫脹関節≧6個 ・CRP≧2.0 mg/dlあるいはESR≧28 mm/hr 30 （２）次の4項目を満たす関節リウマチ患者（日和見感染症のリスクが高い患者を除外す るため） ・末梢血白血球≧4000 /mm3 ・末梢血リンパ球≧1000 /mm3 ・血中β‐D‐グルカン陰性 ・ツベルクリン反応強陽性でない人 （３）本発明の目的及び内容を説明し、本人から文書による同意が得られた関節リウマチ 患者 本発明では、代諾者が必要な患者、小児患者は対象から除外した。また、インフリキシ マブ投与が禁忌である患者（1）重篤な感染症の患者、（2)活動性結核の患者、（3)レミ 40 ケードの成分又はマウス由来蛋白に対する過敏症の既往歴のある患者、（4)脱髄疾患及び その既往歴のある患者、（5)うっ血性心不全の患者）は除外した。 【０１５３】 （エタネルセプト） 以下の（１）から（３）の条件をすべて満たすエタネルセプト（商品名：エンブレル） 未投与患者を対象とした。 （１）過去に1剤以上の既存の抗リウマチ薬(DMARDs)を投与してもコントロール不良の関 節リウマチ患者（インフリキシマブと同様の条件：日本リウマチ学会の生物学的製剤ガイ ドラインによる） （２）インフリキシマブと同様 50 (27) JP 2010-88432 A 2010.4.22 （３）インフリキシマブと同様 【０１５４】 （アダリムマブ） 以下の（１）から（３）の条件を全て満たすアダリムマブ（商品名：ヒュミラ）未投与 患者を対象とした。 （１）過去に1剤以上の既存の抗リウマチ薬(DMARDs)を投与してもコントロール不良の関 節リウマチ患者 ・疼痛関節≧10 個 ・腫脹関節≧12 個 ・CRP≧2.0 mg/dl 10 （２）次の5項目を満たす関節リウマチ患者（日和見感染症のリスクが高い患者を除外す るため） ・末梢血白血球≧4000 /mm3 ・末梢血リンパ球≧1000 /mm3 ・血中β‐D‐グルカン陰性 ・ツベルクリン反応強陽性でない人 ・肝炎ウイルス非感染者 （３）インフリキシマブと同様 【０１５５】 ２．投与方法 20 （インフリキシマブ投与患者） （１）インフリキシマブの用法・用量 体重1 kg当たりインフリキシマブ3 mgを1回の投与量として、添付文書の記載に従いイ ンフリキシマブ100 mgバイアルを10 mlの日本薬局方注射用蒸留水で溶解し、患者の体重 から換算した必要溶解液量を約250 mlの日本薬局方生理食塩液に希釈し、独立した点滴ラ インにより1.2ミクロン以下のメンブランフィルターを用いたインラインフィルターを通 して2時間以上をかけて緩徐に点滴静注した。投与間隔は、初回投与後、2週後、6週後に 投与し、以後は8週間の間隔で投与を行った。また、下記の通り、メトトレキサート製剤 を併用薬とした。 （２）メトトレキサート製剤の投与方法 30 すべての患者に対して、１日当たり6∼8 mgのメトトレキサートを１日３回に分けて投 与した。 【０１５６】 （エタネルセプト投与患者） （１）エタネルセプトの用法・用量 エタネルセプト25 mgを1 mlの注射用蒸留水で溶解し、週2回、3日以上あけて施注した 。 自己注射を希望する場合は、専用キット（自己注射キット）を使用して医師の指導のも と十分な練習をした後、当キットを利用して自己注射を行った。自己注射または家族によ る注射は腹部または大腿部へ行い、施注毎に部位を変更した。 40 【０１５７】 （アダリムマブ投与患者） （１）アダリムマブの用法・用量 アダリムマブ40 mg（充填ずみ注射キット）を隔週1回施注した。 自己注射を希望する場合は、医師の指導のもと十分な練習をした後、自己注射を行った 。効果不十分と判断された場合は、同日中に40 mgの注射2本を異なる部位に隔週1回施注 した。自己注射または家族による注射は腹部または大腿部へ行い、施注毎に部位を変更し た。 【０１５８】 ３．インフリキシマブ、エタネルセプト及びアダリムマブの有効・無効の判定基準 50 (28) JP 2010-88432 A 2010.4.22 DAS(disease activity score)を用いてインフリキシマブ、エタネルセプト及びアダリ ムマブの関節リウマチに対する有効性を評価した。欧州リウマチ学会議(EULAR)で汎用さ れているDASは、疼痛関節数、腫脹関節数、患者の健康状態の全般評価（VASによる）、血 沈（ESR）またはCRPの４つの活動性指標を指数化して、以下の式から疾患活動性を算定し 、DAS28の改善と評価時のDAS28の値の両方を用いて表１に示すように、「有効」、「やや 有効」、「無効」の３種類の評価を付与した（表１）。本発明においてはDAS28のEULAR改 善基準に基づいて有効、やや有効と判定した群を有効群とし、無効と判定した群を無効群 として解析を行った。また、インフリキシマブ投与開始から14週までの間に、関節リウマ チに対する有効性の評価を一次無効とし、してインフリキシマブ投与開始14週から30週ま での間に、関節リウマチに対する有効性の評価を二次無効とした。一次無効、二次無効の 10 判定はDAS28、有効判定を用いて「有効」、「無効」の２種類の評価を付与した（表２） 。 【０１５９】 〔数１〕 DAS28 ESR有効性 DAS = (0.5398 × √Ritchie関節指数) ＋ (0.06465 × 腫脹関節数) ＋ (0.33 × In赤 沈値) ＋ (0.00722 × 患者の健康状態の全般評価) 【０１６０】 〔数２〕 DAS28 CRP有効性 20 DAS-CRP = (0.5398 × √Ritchie関節指数) ＋ (0.06465 × 腫脹関節数) ＋ (0.17 × I n (CRP + 1)) ＋ (0.00722 × 患者の健康状態の全般評価) ＋ 0.45 【０１６１】 〔表１〕 30 【０１６２】 40 〔表２〕 【０１６３】 50 (29) JP 2010-88432 A 2010.4.22 ４．投与、観察、検査のスケジュール （インフリキシマブ投与患者） 本発明は、主に表３に記載した観察・検査スケジュールに沿って行った。初回投与日な らびに30週後のインフリキシマブ有効性はDAS28ESRおよびDAS28CRPを使用して判定した。 また、遺伝子解析用として別に血液約10 mlを採取した。また調査期間におけるすべての 副作用について調査を行った。 【０１６４】 〔表３〕 10 20 【０１６５】 （エタネルセプト、アダリムマブ投与患者） 本発明は、主に表４に記載した観察・検査スケジュールに沿って行った。初回投与日な らびに24週後のエタネルセプト有効性はDAS28ESRおよびCRPを使用して判定した。また、 遺伝子解析用として別に血液約10 mlを採取した。また調査期間におけるすべての副作用 について調査を行った。 30 【０１６６】 〔表４〕 40 【０１６７】 ＜全ゲノム遺伝子多型決定＞ 50 (30) JP 2010-88432 A 2010.4.22 本試験ではHuman Hap 300 Bead Chip (317,503マーカーを搭載;Ｉｌｌｕｍｉｎａ社)な らびにHuman CNV 370-Duo Bead Chip (370,404マーカーを搭載;Ｉｌｌｕｍｉｎａ社)を用 いて317,503 SNP（Human Hap 300 Bead Chip）ならびに370,404 SNP （Human CNV 370-Du o Bead Chip）の遺伝子多型を決定した。遺伝子多型の分析はdeCODE genetics社(アイス ランド)において行った。 【０１６８】 本試験において各SNPのdbSNPデータベースにおけるrs番号はNCBI SNPリファレンスbuil d126に基づいている。また、配列情報、染色体位置情報はヒトゲノム国際プロジェクトbu ild36.2に基づいている。 試験したSNPのアレルおよび遺伝子型頻度を決定し、統計分析を実施するため、臨床デ 10 ータと組み合わせた。 【０１６９】 ＜統計分析＞ 遺伝子型とDAS28ESR有効判定、DAS28CRP有効判定、副作用発現との関連をフィッシャー の正確確率検定により評価した。遺伝型の解析において有意水準は１％とした。また、検 証研究における遺伝子型の解析の有意水準は5%とした。これら遺伝子型との関連の分析は 、plink (http://pngu.mgh.harvard.edu/ purcell/plink/ ) を用いて行った。その他の 分析は、SPSS ver.15.0.1J（SPSS Inc.,Chicago,IL,2006）を用いて行い、有意水準は5% とした。 【０１７０】 20 インフリキシマブ、アダリムマブの構造は違うが、抗TNF-α抗体という作用機序は同じ であるため、インフリキシマブ、アダリムマブ両方の薬剤を投与した群を、抗体製剤とカ テゴリー分類し（図１）解析を行った。また、エタネルセプトは可溶性受容体製剤で、抗 体製剤とは構造が異なるが、TNFを阻害するという作用機序が同じであるため、すべての 投薬患者をTNF阻害薬とカテゴリー分類し（図１）解析を行った。また、インフリキシマ ブでは一次無効と二次無効の機序が違うと考えられるため、この2項目についても解析を 行った。 【０１７１】 〔実施例１〕研究対象群のプロファイル 本発明の目的は、リウマチ患者におけるTNF阻害薬の有効性・副作用発現（生物製剤使 30 用時の最も重要な評価点）に対する個体の感受性に関連している可能性がある遺伝子多型 を、全ゲノムより同定することである。 【０１７２】 本発明では208名の関節リウマチと診断されかつTNF阻害薬の投薬をうけている患者を一 次集団とした（男性53名、女性155名）。基本臨床データは表５に示した。また、男女別 の基本臨床データは表６に示した。また、206名の関節リウマチと診断されかつTNF阻害薬 の投薬をうけている患者を二次集団とした。（男性22名、女性184名）。基本臨床データ は表７に示した。また、男女別の基本臨床データは表８に示した。 【０１７３】 〔表５〕 40 (31) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１７４】 〔表６〕 (32) JP 2010-88432 A 2010.4.22 10 20 【０１７５】 〔表７〕 (33) JP 2010-88432 A 2010.4.22 10 20 30 【０１７６】 〔表８〕 (34) JP 2010-88432 A 2010.4.22 10 20 【０１７７】 表９に投薬期間に現れた副作用の種類と頻度を示す。大別して、局所アレルギー、全身 アレルギー、感染症、消化器が見られた。 【０１７８】 〔表９〕 (35) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１７９】 50 (36) JP 2010-88432 A 2010.4.22 DAS28のEULAR改善基準に基づいて有効、やや有効と判定した群を有効群とし、無効と判 定した群を無効群とした。DAS28ESR有効判定と年齢、発症時年齢、罹病年数の相関解析を 行った（表１０）。DAS28CRP有効判定についても同様の相関解析を行った(表１１)。DAS2 8ESR有効判定では一次集団エタネルセプト治療群で、DAS28CRP有効判定では一次集団イン フリキシマブ治療群、一次集団アダリムマブ治療群、二次集団エタネルセプト治療群にお いて有意に(p ＜ 0.05)、無効群での罹病年数が有効群より長いことが示された。また、 二次集団エタネルセプト治療群において有意に(p ＜ 0.05)、無効群で発症年齢が高いこ とが示された。 【０１８０】 〔表１０〕 10 (37) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１８１】 〔表１１〕 (38) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１８２】 副作用発現と、年齢、発症時年齢、罹病年数との相関解析を行ったが、有意な相関は見 られなかった（表１２）。 【０１８３】 〔表１２〕 (39) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１８４】 各治療薬群の有効性と副作用発現との相関解析を行った。二次集団エタネルセプト治療 群において相関がみられた（表１３）。 【０１８５】 〔表１３〕 (40) JP 2010-88432 A 2010.4.22 10 20 30 40 【０１８６】 50 (41) JP 2010-88432 A 2010.4.22 〔実施例２〕TNF阻害薬群のDAS28ESR有効性判定に関連するSNPの探索 Human Hap 300 Bead ChipならびにHuman CNV 370-Duo Bead Chipに搭載されているSNP がTNF阻害薬群のDAS28ESR有効判定の個人差に関連するか否か、フィッシャーの正確確率 検定で解析した。 有意水準0.1%において345SNP(108遺伝子)がTNF阻害薬群のDAS28ESR有効判定に関連して いた。また、有意水準0.1%∼1%の範囲でも1143SNP（654遺伝子）が有意に相関していた（ 表１４）。 【０１８７】 〔表１４〕 整理番号（配列番号）/染色体番号/NCBI_SNPリファレンス/染色体位置/SNPの種類/配列/T 10 NF阻害薬治療有効SNP(DAS28ESR)/遺伝子シンボル/遺伝子名 1/1/rs12405445/14604606/[t/c]/gagaggaagcgggagaggcaatgggataaacactctggttctagagtcca aaagacctgc[c/t]tcagcacttcctagctgtgtgtcatttgggcaagttacttaccatattaatcagcatcct/c/-/ -/ 2/1/rs943918/14598636/[c/t]/tggttacgtgactgaacccagtacacgcccccaggtgactcgtgagcccatc tcaaagct[c/t]gggattggtcctaatgggtggctggctgcttgcctgttactgagagagtcctagatgtct/t/-/-/ 3/13/rs10508186/107168565/[a/c]/tgcctgaccccttctagagtctttcccactctagatttctgaccttga tgttctttctct[c/a]tgttatgaccctattgctctgtctcagaagctcagttataatgctttatgcagttccgga/c/ LOC728215/similar to transmembrane protein 28/ 4/3/rs6550578/21255054/[g/a]/ttagtcaaagggaagtatgggtaaaaggaaagggaaaactttcctttcctc 20 taggttttc[a/g]ttgccaaaaaggaagtatcgaaataatttcagttggctgatgaatggtaaaatattccag/a/-// 5/13/rs9319110/84510389/[t/c]/acacttgtgaagacagatatgtgttgtaataattagaaaagccatattta cattgattaa[c/t]tggactatatttgacaaatagataaaaccacttatttaatatcagataaatctaatctat/c/-/ -/ 6/13/rs9319107/84509744/[c/t]/aataatatagtcgtacactagttcaaacattttatatttcctcaaatgtt tcctttaagt[c/t]ttactgattatgagcataaaaaccagttttactcaaatactgtatgacatgttactatca/t/-/ -/ 7/1/rs3753472/201398156/[g/a]/aggagaggtagacagtgatagccctagacaggagagagggaggagacttc tagctacaga[a/g]gtgggtccctcccctcttctctcctcacccctcacccttctgaccacccagagcccccgg/a/AD 30 ORA1/adenosine A1 receptor/ 8/10/rs2104483/92068677/[g/a]/gaacccctaagtggagggtattttctctctaaaaccctcttgctgctggt ctctgaagga[a/g]attgttatatgccttccttgtcatcaccacttcagaccacttctctttcccatttcctga/a/-/ -/ 9/10/rs10881780/92054214/[g/a]/aatcctaatattttctccaaccccacttttggagactagtgtctcatgc agtgtagttac[a/g]aattcatagtctctatgggaattaggttctgaagtcaaaacataagttgaacatcacaga/a//-/ 10/13/rs3764124/112945321/[t/c]/tggtattgatttgcttttgtagacttttggaacagcgatcgtaatcaa tcctgagaaaga[c/t]aaagacatggtccaagacctgttggacttcaaggacaaggtggaccacgtgatcgaggtc/c/ CUL4A/cullin 4A/ 40 11/1/rs6679498/209779313/[t/c]/cctgtcctggaagcacatacaccaatacaacacctcctaacaagcaagt cccattcagtc[t/c]tcaagcaaagttcagctcccactctgcacctctgcgacacccttgccttcacgtgaatgt/c//-/ 12/13/rs7994324/112954498/[c/t]/cccctgagaggcatccggaaaacacgagcaggatccgggcgatgggaa aggctggtgcac[t/c]gaacgctgggaacttgaaaatgcagcaaccacaattttaaggatcagtagaaagtttgga/t/ CUL4A/cullin 4A/ 13/12/rs1976935/52380303/[t/c]/catccacagatacaaaacaatatatacatacacttgcaggaatacatat acatacataca[c/t]ttacttgcatgaaagcacatacacacctctcttaatcaaatgcaaaaattacaaagtcta/c//-/ 14/13/rs3024718/112861854/[g/a]/acatgctttgggaccctcaggtgggaagaggctccagagaccactgcc 50 (42) JP 2010-88432 A 2010.4.22 gcgggtcaactc[g/a]tttgccttctcctcctggaaatcgcagagcctgctgcaatgtataagtttcttctttatg/a/ PROZ/protein Z/ 15/20/rs4809401/62208012/[c/t]/cacacgggcagcacgaagcccaggaccaacgtgtagacacggctggcct tgaaccagacc[c/t]gctcgggccacgggaagctcagcccacagcttgggacctgcagctcgttgctgtagacgc/t/N PBWR2/neuropeptides B/W receptor 2 16/19/rs8107048/15591767/[a/c]/gaggctaataatcctcactaaaaggtggtaggagcatgtaatggactca tgtctctgaca[c/a]ttagtaggtggtcagaaggagtcaatttccacatttttctcacagaagccctgtaaactc/c/C YP4F8/"cytochrome P450, family 4, subfamily F, polypeptide 8" 17/19/rs3764561/15585294/[a/g]/aatgaagagggagaccctccaagggcagccatgggatgcggcacccagc tgcgcaaaaat[a/g]cacatgagttcttcttcctttgcagttcatgctgagatcaccaacacatgggaccacaca/g/- 10 /18/10/rs7923028/82345175/[a/g]/tgttttcacatatgtttatgctgaagcccactaggtaaagaaggtgtga gcagctggccc[a/g]ggtgaggaaagtgagggggcccatggtccctggtcccctgaatcttccccgcttcaggga/g/S H2D4B/SH2 domain containing 4B 19/14/rs3814835/91484133/[g/a]/cggggagagaaaagcgtcctaagacttgcattgcacaagctgaagtctg gaattcgcacc[a/g]gcgggattccatcctcttcccccccaccccaccccgctgctccccaccccttcttcggga/a/F BLN5/fibulin 5 20/9/rs11103714/136499769/[a/g]/ctcttcctaatctgcctcttgtcagtttaatttgcaggacacagtggc atcatcagagat[a/g]gcagagctctttcactccatgggaactgctcttggagcccctggccccttgaggggacct/g/ -/- 20 21/5/rs1363602/169539456/[t/c]/aacagatccatgaagagggaggctgagagactcactctgtgtcctcgag tttgccctgac[c/t]gactttatggagattccaggagtgactctggtcttgtctgggtcatcacagggcattttg/t//22/15/rs934192/52182570/[a/g]/ggtagattttgtcctctgtgactgaagttcattgtctggcagtttctgag ggtacaaatc[a/g]gggagagaaagccctctttctgcagtatttttctcagaagtatttgtttcattccgatca/g/UN C13C/unc-13 homolog C (C. elegans) 23/17/rs8075751/16881961/[g/a]/ccatgggaggccctggaaacctgtagcattcacacattcctccagatga attttattatc[a/g]atgattagcagaaaaagggcgagatgagagcccagctctcaggtgtggagaactgcttgg/a/L OC100128283/similar to hCG1775427 24/13/rs2316442/112925488/[a/g]/cagaactctcttccagcaaaaacaagctttttgagagcaggacccgtg 30 ccattcatgcct[a/g]tccctggtccccaacgcacagtgctgagttggacagaaacaccccatgtttactaggtta/g/ CUL4A/cullin 4A 25/10/rs10882406/95966922/[c/t]/cctactttgcaggtgtgtaaccttgggcaagctagtttactcactctg aatctcaccttt[c/t]tcatctgtaaaatggcagcagtattagtaccagccttgtagagctgaaaggataggataa/c/ PLCE1/"phospholipase C, epsilon 1" 26/8/rs2667995/57115654/[c/t]/ctgaagcaatccccctgccttggcctccaaagtacctggggttacaggca cacaccaata[t/c]actggcaagcaatatattgtggacctttgcagcataaacctgtgttgttcaaaggtcaac/t/-/ 27/10/rs11186122/92067254/[a/c]/taactcagagttctaaaacttcagacacaaccttgaagtcctgtaaat gcaacacaatgg[c/a]atagcgtaggaaaagagaaaagaaatgagatgtatctaataaatgtgtgtgggcagagag/c/ 40 -/28/6/rs13206817/38281343/[t/c]/tgtatttatgcgaagaaaaataaaaataataaaataaaaacttcacctc caatgcattca[c/t]aaggaactaccagaaaatgtgttccaccaaaacaaaggaccaacttaagataaagaaagt/c/B TBD9/BTB (POZ) domain containing 9 29/15/rs1437543/59255759/[a/g]/cacatgtgttcaaacactctcttcttggtagatagtcagactatttggt gttccttctgc[a/g]aaccgccctactgtcatttaagtaacaaactctgttgatacaggagtggcctctaactca/g/R ORA/RAR-related orphan receptor A 30/12/rs4128893/94647740/[c/t]/aagagaaaagctgaggttactgatagatatctgacttctggtgcacaaa tcgtgtctcca[c/t]ggtatttcatttgtgtcttgccaattttgtaatagctggaagcatacttcaatttgtcct/t/N TN4/netrin 4 50 (43) JP 2010-88432 A 2010.4.22 31/2/rs12622011/76452095/[g/a]/ctgcagtttgtttttagggagacatctgttaaactcaacagcatagaac ttaacagaact[a/g]gttaagaacgtagcttaggaggatggtgtttccttacttgaggaaccaaggatggaggat/a//32/5/rs3913348/20983113/[g/t]/gaatgcaatacccattgcaacaccagaaagttttttttgtggatattggc aaattgattc[g/t]gaagtttctatggagagacataagacccaagatatgcaacataataataaaagagaagaa/t/-/ -/ 33/8/rs4404876/10440498/[g/a]/aacaagcagttttcagaccagcagtagtccctgttccacacttcagaagc atttccctac[a/g]agacccagactttaatcaccaagaaatagaggccacctggctaccaagcccaggctttct/g/LO C346702/similar to hCG1643218/ 34/3/rs982953/24486257/[t/c]/ataaaaataagttacccaaacggttttccattctttactcgtacctcactc 10 tttaccacg[c/t]gctcatagtttgttgctcttcaacacttttctctaaataagttaataaaatgtattcttc/t/THR B/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncog ene homolog 2, avian)"/ 35/6/rs1962432/1625805/[c/t]/ttctgatccggcaccgtgacctgacttctcacacggaaagcagcgtggacc ttctggcct[c/t]cctcccttgggcgcccagccaggacacgcaaggtcatactgctgaggccctttgagatcc/t/GMD S/GDP-mannose 4/ 36/6/rs2814811/1615984/[a/g]/tagttcagtagtgctagagagaaagataaccatctcctcgtgccttttgtc ttcagccat[a/g]cttttagttttcattctgcattccatagttccaaacgttgaagtcatctgcaggtcaaac/g/GMD S/GDP-mannose 4/ 37/9/rs4978125/20769843/[c/t]/attgtatagctcattcttctgggcattttaattcatgattttgggagtga 20 attgctcttt[c/t]acctacagtgtgccttggaaatggctttagcacatggaggggatccttggctcctaggct/c/KI AA1797/KIAA1797/ 38/2/rs7598826/100839866/[a/g]/gggcaggtgatggagagtggtagggcgtgcatttctgccagaattggga gtggctggtgc[g/a]gcatggataggacaggctgtccaagcacaagcttaagatgttgtcattcctggccgggca/g/N PAS2/neuronal PAS domain protein 2/ 39/1/rs12030672/50507982/[c/a]/atgtaaaaatgcagaaaaataggacccacattgagaagacgcatattca ttaggaactga[c/a]acagatattagaattaggaaatatagacaataaatagttatgactgtattctctctgttg/a//-/ 40/3/rs9827931/21273644/[t/c]/tcttcctgcagccaacacctgcatctcttttttggcagactgcccttgat ctactggcac[c/t]gctttgcctcaaactgggaaagccagaattactggcaaagataaatgtctttatttatcc/c/-/ 30 -/ 41/13/rs10508187/107191904/[a/g]/ggtgagaaagcttgaatgatgacaggtatttaacactgagaaaatga tggtactataaac[g/a]ggaagagaaatatcttgcaataatacaagggaacttttagcacttctaagttcatttctg/g /LOC728215/similar to transmembrane protein 28/ 42/13/rs6492073/107185360/[c/t]/ggtggctaaccagtgaaataaactccacttaggaatgcatgggatcaa agactactgctc[c/t]tgggaggaaaaaatggagttgcagattggagagcctgccttcccaccaagaatacaatat/t/ LOC728215/similar to transmembrane protein 28/ 43/5/rs6595959/97938006/[t/c]/ctctcctcattatcagcaatgtagtggtgcttttcatttcatggatttat tgtttgtgac[c/t]gtttatgttatatgtgagcatcaggtaatgggtgacaggcaagattgcaaacctgaggag/c/LO C642909/similar to C-terminal binding protein 2/ 40 44/5/rs17132963/97957145/[t/g]/aagcaaagagatccaagaagtagataggtcttggtggtgctcacagtgg aactggagaat[g/t]cacatgcagctacagacaggtcagcatctacttcgccttctgtttatgctgaacaatagc/g//-/ 45/8/rs10086002/10429327/[t/c]/tcttgaccagaaaacattaactgtcctccctgattagagtttgttataa tactccattta[c/t]tctagtcacctctcaaggatcatggaatgagacatcatctctccactgaagactgcttgc/t/U NQ9391/tryptophan/serine protease 46/14/rs4981223/20041624/[g/a]/ggatcaacattgtaaccctcctggttttattcacccagagtatagggac tgataatgata[a/g]tgctgctttggatagtctcctatctagggctaaatgatcagatttgcaaaatccagatat/g//-/ 47/10/rs10827167/33317788/[t/c]/tcttcctccccaactgacatcctgtactcattaatcaataactctcca 50 (44) JP 2010-88432 A 2010.4.22 ttcaccctcccc[c/t]gagggagactattcttgttattctctgtctttttttttttttttttaatagctgccattc/c/ -/-/ 48/3/rs12487277/21247227/[t/c]/tactgataattatatttccatatcaactgtactaccctctccttttgat tccatgtacac[c/t]gcctttatttgggcctccatcacctctcccaggcactctaattaaagctctctaagtagt/c//-/ 49/6/rs335419/155716021/[t/g]/tgctagtacttctctgccccagcctgggagatattctttccacacaggga actgttggga[t/g]atttacctgtccaagcctttgtgacaggtttttaagtctctgtcccaccgaaaatcatga/g/-/ -/ 50/1/rs1766163/91087098/[t/c]/ttaaaaagtcattgagggaagtcatctaattttctttcagcttgttttga ccccaaatta[c/t]attatcctgacttgaccacccaccttattcttcagagcactgaaggatgctaaaggaaga/c/LO 10 C149351/hypothetical protein LOC149351/ 51/17/rs4969230/76340856/[t/c]/gtgcctcccccagctgaaagcattctgtttggtggaactggttctgata ttttccagctc[t/c]tctcaattatttccaggagcaggcagagcagtgtgtgtacataatccctcatgtgttata/t/K IAA1303/raptor/ 52/14/rs1952500/24625196/[a/c]/aggcactgttgctaggtattgttgattcaaatttatttagttttttaga attgtaattat[a/c]gtgtttggaatagttactaagctgctattatgtgcacggtattgtgtttaagtgtttctg/c//-/ 53/12/rs1676428/88189891/[c/t]/ctccttggccatcacatattgttgagcaagatatcattcactcaacagg tattctgtttg[t/c]tttgtgtttgtttgtttcccaaatgcaggcatattaatttgccagggctgctatcacaaa/t//-/ 20 54/8/rs1362911/30984486/[a/c]/taaagtgtgatcaacctttaaaaagctatttttttcagagtcaaatgacc cgctaacata[a/c]tcttataataatgttttcaacttgaaaataaagaggtgagaaaactcttcgagttgaagg/c/PU RG/purine-rich element binding protein G/ 55/4/rs4513549/153845564/[t/c]/caggtaaccatcaccaccaaatcaagatagagaacacatccatcacccc caaaagtctcc[t/c]tgtgccccctcggtcatccctccctcctgcccttgcctgtcccccattcccaagaagcac/c//-/ 56/6/rs9486920/109135395/[t/c]/gtgtctattttttcaccaatcccacgtgcagcacaatgcctgtttacac agcaggcactc[c/t]gtcaatgtgtacctcaaggaagaagcaatgaatggaccaatgaatgtgcttgctcttgaa/c//-/ 57/9/rs1049927/112058576/[g/a]/taaagggagagagcaagcagcgagtcttgaagctctgtttggtgctttg 30 gatccatttcc[a/g]tcggtccttacagccgctcgtcagactccagcagccaagatggtgaagcagatcgagagc/a/T XN/thioredoxin/ 58/6/rs4711930/49660494/[c/t]/aactatgccttaatactaattatacaattttgatttatattaatatatgc agtgcttgat[t/c]atagacatatatcaatcacaactgcttctgcaaccttagatgttacaaacataacctact/t/-/ -/ 59/9/rs4877950/87530274/[t/c]/aggatggtagggggctaatgaacatcagcctctccctctcaaattacctc cacaaacctc[t/c]ccataggcaccgccaactacctgatataagcaaaaaagctctacaagtgtaatggaaaat/c/AG TPBP1/ATP/GTP binding protein 1 60/1/rs10916959/21504250/[a/g]/gtgaaaaattcaaccctcctttgcactagccacatgtcaaatgcttcat agccacacata[g/a]gctcgacagcatagacacaggccgtttctatcatcccagaaagttccactggacaacact/g/- 40 /-/ 61/12/rs7961471/65422433/[t/c]/aaacggagagaaactgataccaaacagaaatatttgcttgtaatcttca aggaaccagta[c/t]aaattgctacacgcagctatgccacccacaagggcatcctgacaagactaccagcacctc/c//-/ 62/4/rs4599440/61648868/[c/t]/attgatgtaatttcttctgacagatgtctgttgaacacccccataagccc aatgctatat[t/c]tgatgacagataaaatataagagaaaaattaaaatcgttccagcctatgtgaatcttgaa/c/-/ -/ 63/9/rs10811399/20756254/[a/g]/agaaatgagctcggtggaatatttctgggaatctgtggctttttaacct aacagttatgt[a/g]agaaaaaaggggatacatcatttggaagtactggaactagtgacagtagcatacttaatc/a/K IAA1797/KIAA1797/ 50 (45) JP 2010-88432 A 2010.4.22 64/10/rs6481819/33339465/[c/t]/tgcttcctgccctcctagcctgctggaaggtctcctgtggttttggagc tcacaggcaca[c/t]gaggaataattaaaaaccactgccatgcgaaagggtgttttaacgagttgtcagtgaatg/t//65/2/rs11126680/78829371/[t/c]/tcataagtatagtacactagtttactcttccatattgctgaaatcataa gttattatccc[c/t]attttagagattaggaaccaacagtaacttcttttgggaagagaggaaactgggttccca/c//66/6/rs6942280/42225344/[a/c]/agattcaatgaaagagtgggttaaggtgctcagcagagggtccagctcat ggtagatact[c/a]agtacctgtgtgctctgtccccctaccttgtaggtagccaaagctccctaccctgctttg/c/-/ 67/11/rs2511188/77598578/[c/t]/cctcctcccccacttcttccttctccgttctctcctccttcccttcttc 10 ctccctctcta[c/t]cctttcctcctgactgctctgcccaccagcttccttggagtccaggccttcgatgtacag/c/U SP35/ubiquitin specific peptidase 35 68/20/rs1011120/56120836/[g/a]/cttccagctaatgagctcccaagggggcacaactcaatggctcaccaag catcccttctt[a/g]agggtgaccagctattctggttttcctgagactgaggaggactccaggaggcagaatttt/g//69/6/rs4896886/147095325/[t/c]/tggatgaaagagagcccaggtggttggttcaccatttcatgctaccaag attactcctca[c/t]gggctcaatgtagctggccctgatttaatatgtaaggggtcttggtgaatgaatcactta/c/C 6orf103/chromosome 6 open reading frame 103 70/11/rs2510044/77586662/[a/g]/ctaagctcagccctgtcccctgttccagaggaggagccaccatctagcg ccctggccagc[a/g]tggtccagcacctcccattggagctcatggatggtgttgtccggaacctcagcaatgatg/a/U 20 SP35/ubiquitin specific peptidase 35 71/8/rs6994118/98438230/[a/c]/actctaggcatagtcatgtaaaagtcaatcaatcaatacatggattaaag tgtattttga[a/c]tatataacactaagcagtatcacatcctgtgggagcctccaaggtaaaccagtaacaaaa/a/-/ 72/2/rs10498102/221786628/[a/c]/taaagacatagatgtaagcaagaagtaggtagcatatctagtacgttt aatcccgatagc[a/c]attggcaccatacctagaactaattatagtagtatattttgacattgtcatcaaaagatg/c/ -/73/9/rs1029372/135468263/[g/a]/ctgcagccataagacgttctgcagttgattgactgagcccagcaacagc ccctttgatcc[a/g]ttttcactgaacctgtgtccactcaactccagatgatctgtgcaggtcaagatcaagccc/g//- 30 74/9/rs7021708/20732210/[a/g]/aatgcttcccaacattggtgcccattagaaccacctgggtgtgcttaaaa agagacaaac[a/g]tggtaacgatcaaataccctagataaaatgaatccgaatctccgccatgaggcctagtgg/a/KI AA1797/KIAA1797 75/19/rs1725489/43269866/[a/g]/gagatgctcttggcaaatcaaaggctagtctaagggcaaaatactgtgt ggtaattaatg[g/a]ccccgatcagaacagcatctgcagggggttcaacaatctccagctgatcagagaatggaa/g/S IPA1L3/signal-induced proliferation-associated 1 like 3 76/13/rs9518579/101279382/[t/c]/aaaggtcagggaaattcatttgtggtttctgcccctcggggtctgtaa ctgctgtgtttc[c/t]ggtgtttccaaattcaagtttttgctatttatccctgggctgggagatagatctaattgc/c/ FGF14/fibroblast growth factor 14 77/10/rs1530064/132938782/[g/t]/agaccctccacagggaacggtggccggtatatcctacttggggaatct 40 cattccacgaac[g/t]cagggaatcctgaggagacacacatgggttgtgaaccgagtcctggctgtcactcatcgc/t/ TCERG1L/transcription elongation regulator 1-like 78/2/rs4853238/76432083/[c/t]/aatggagaaatggtgatgtttgtcaaagagagaaagtaaactgaatactg ttagcagaag[t/c]agggtaaaggattttgttagtagattgccaaatatcaacaattctctcctccaagtgaag/t/-/ 79/10/rs3847346/71123154/[g/t]/gaatgggtgggccaaaatgcccatccatcatttaccacatacttagaaa tacctactgtg[g/t]ccctgtcattgggctggtaatgtcatggcgaatcaggcagacatggctactgtcctcttc/t//80/19/rs7245699/40691331/[c/a]/tactaaggtatttacaagaggcattttaaatcagtggttgaagtgattg aatacatggga[a/c]tgggaatatcagtgaagtattttgggggaaaattttagttctagctcatcaatttcctcc/a/D 50 (46) JP 2010-88432 A 2010.4.22 MKN/dermokine 81/14/rs242400/55729825/[a/g]/aaattagcaatcatggccacaatcacggttttagcaaaataaattcttgt caaatcagat[a/g]atgggttaaattcaaggaggaggtagcttcaactgatcgaggtaatagagaaaatcagca/a/PE LI2/pellino homolog 2 (Drosophila) 82/13/rs4335654/101307317/[t/g]/ctcttttgcacgtggtctacggtataggtaatagaaacagtattataa aaggtccatagt[t/g]gaaaggcagatgagttcattggagatgtttacattaacggggagtcattaagtatcaact/t/ FGF14/fibroblast growth factor 14 83/1/rs4648592/1790894/[a/g]/tcctcctcccgtgaatcccaacaatcacagccacagaaatagtaagcagga aaaaacaag[a/g]aggtggcagtagaggagcctatttgtcttatcacagttattcatcacgtagctggttcct/g/GNB 1/"guanine nucleotide binding protein (G protein), beta polypeptide 1" 10 84/7/rs10275903/45860630/[g/t]/ctgttgggtaactccgccctctggtggccatatatggctaaagcgagta caagtccaaac[t/g]cacacctggaggacaggtgccatcgcctgaaagcaacagtaaccacgacaacaaggccag/t//85/7/rs7791745/42351145/[t/c]/ggctggaagggttgagcaggagtctagcaagacttgctggagtataactg ctcagggaca[t/c]tgcctgaataaggtcgctctttggaattaagaaagaataaagctgcatgggcatattatt/t/-/ 86/9/rs4135168/112056706/[g/a]/agggtgacaggaactttaaaaaaagcactacagcctggggcccaaaggc cctgataatca[g/a]ttaatcctcaaaataacaatccaaagtcattgatcgaaagttacactaatttgattgtta/a/T XN/thioredoxin 87/12/rs7969151/52445544/[a/g]/gtattctctcaagtatcattcagacagaattcaggacacagaaagttca 20 caggtgtggga[g/a]gatgcctgataagcagtcagttttgtggggtcattctcagaagactcctgggagataagc/g//88/10/rs1887183/92043041/[c/t]/acttactagcagctggggtagctaactcctagttgtggtgacagaaata agggatgcaga[t/c]gcccctgtcaggcagttgtggtcatatcatgtgtcaagatcaagaagtgcaaagaggctg/t//89/8/rs9969668/135800760/[a/g]/actttggacaacttacttatctgcaatgtgcttcccttctctgggcaat gaaggtgttga[g/a]ccccacatcaggggttggtggaagggaaatgagacaagaaaatgcagttgagtgccacgg/g//90/8/rs4442136/74524905/[g/t]/ccttcaaaccaacagaggatgggtaaatttggatgcatggatttgggggc tttatgaatt[t/g]agacattttaaaatatgtattaataagtaacagaaacttacttctttaggcacaatatta/t/-/ 30 91/5/rs9292558/34699587/[t/c]/cagtaggagattaacatctctcaactactcctgcctcagaggtcattaag cccctcatgg[c/t]ggtcatcagatatagagttgtcctagtctagaggagaattaaacaataatcaaaaggcag/c/RA I14/retinoic acid induced 14 92/13/rs342594/59176565/[c/t]/ctggtcctcactgtttccacagctcttggatgatctttgtttcctctggt attctagttg[c/t]tcttggcaggaatgttgatctgccaccctcatacagaagcagaagcttgctgtggttatt/t/DI APH3/diaphanous homolog 3 (Drosophila) 93/15/rs17691453/37331238/[c/t]/aaaaagtgtagggctctttgacttttcatttccctttctatctactta ctctttgtgcct[t/c]ctccagttagtaccacactagagaagtgttaggtagaggaagaggaagaaagaaaaaagg/t/ C15orf54/chromosome 15 open reading frame 54 40 94/11/rs1981405/77653856/[a/g]/tatatatatatatatatatgtggtatagaaggcccgtttattacatagg gtcttagaatc[a/g]catgaatatgaacccacaacattaatgactttagtctaaacgtggtcttggataagtaaa/a/G AB2/GRB2-associated binding protein 2 95/9/rs2279619/539518/[c/t]/agctgttggagccagaataggaaaaggaaggaaaaaactgtcctccctaagg actgctag[c/t]tttttattttgaaggaaggaaaactgcttaacatgaacgggaccccgtcttgaagcactg/t/KANK 1/KN motif and ankyrin repeat domains 1 96/12/rs7966574/93431848/[c/t]/tcacaatacagagtaagatgtgcaacaatagaggtccatggtagatgag aggggaaagtg[c/t]ctcaattcttgagaaagccaggaaaggagaaaacgaggagagtaagaagagacaaaactg/t//-/ 97/9/rs4842152/136786830/[g/a]/aatgacccgataagccgcagtttggcaggtccgagggtctatgcaggga 50 (47) JP 2010-88432 A 2010.4.22 tctgggcatga[a/g]acagaggcctgggctggataattccaggaggattagcagctctggaatcgactcttggta/a/C OL5A1/"collagen, type V, alpha 1"/ 98/8/rs2448962/79163162/[a/g]/ccaaaactacatcatccttcatccccataaaagtgtaaaacaccttcatg tgatttgctc[a/g]ctcttattcccagacccaacatatatttgtttgcccctgtcatagctggttgtgggaacc/g/-/ -/ 99/17/rs9895159/12074911/[a/g]/tcagtctgctgataaagctcagacttctgcagacttctttttcttagtt tctgttaggca[g/a]gaaacccagaaaaaaattcagacttttttttttttttttgccccaagagcacaatgaact/g//-/ 100/2/rs1526638/76445730/[a/g]/tcagttattgctttatattttgagaccacataattaggcacttacagat tcaggattgct[a/g]tatcttcttggtgaatttatccttttatcattatcatgtgatttatactaagatttttac/a/- 10 /-/ 101/10/rs7069120/90091703/[a/g]/gattttttatattctctcaaaaagatagtttctactcaccacatattc taggtgctccct[a/g]agtactcccagtctacttggcaggaaagttgcagccatgtaactattaggttggtgcaaa/a/ C10orf59/chromosome 10 open reading frame 59/ 102/1/rs2486542/242308572/[a/g]/gcagctgttgttggctagccctaaggtgagccacggtcacagaccttc aacccacagcac[a/g]gttgggggatatgggtgattttcttttcttttcttttcttttttttttttgtttgttttt/g/ -/-/ 103/19/rs1047854/1432481/[t/c]/gaggctggagcaccccaaaagccaggggaaagtggagggagagaaacgt gacactgtccg[c/t]ctcgggcaccgcgtccaacctcagagtttgcaaataaaggttgcttagaaggtgctcagt/c/P CSK4/proprotein convertase subtilisin/kexin type 4 20 104/8/rs11778073/99498967/[t/c]/gactctgtctcaaaaaataaataaataaataaacaaacaaacaaacag tttctggagcca[c/t]cctgttttgccttgaatcctggctctatcattggtgagttctgtaactgtgaacacggta/c/ -/-/ 105/8/rs4130404/99490091/[a/g]/ggcaatcatttgtattctaaataggccttcctgacacatcctccttaaa atgttagatca[a/g]aaaaagaattc/g/-/-/ 106/3/rs9819530/122870474/[g/t]/ttttgttctcagatccaaagtttcctacaattttcttataacttaaag caaaatcaacac[t/g]ttctctgtttcagagtaccaaatgtctcagtcatcactgtttcctactcatgttttgatt/t/ GOLGB1/golgin B1/ 107/1/rs10864418/9412559/[g/a]/ccttatagctccagcctggaattcatcctcaagaaaaatccttctggct tctcaggctgt[a/g]aacttagagttcttcatcccgtgtcaaatctgtcagcagatcctattggcttttcttttt/a/- 30 /-/ 108/1/rs6685648/15697782/[t/c]/caagggaagaaatgtgtctggagtctctattcctgacttctgtcttgca aataccagata[t/c]agaactatagaacaccagattccatggatcttgaaagtgatctttttttttttttttttt/t/C ASP9/caspase 9/ 109/12/rs10878506/65448046/[g/a]/agaggggagggttaagaatcaacgcaattcctgtcaaatgtgtatat gctgcaggcttat[g/a]aaagggagaatcaattcactccagcaatgagtaataacatctatgtccttgaagaagcac/a /-/-/ 110/1/rs358689/91217121/[g/a]/acagcatgagaaaatgtcaacgtctaactctgtgttcaaacattatggca gaagctgcag[a/g]aaggaaaagcaacaaattgatccctgtggggaagaacctcttcttgctttggacttgcta/a/ZN F644/zinc finger protein 644/ 40 111/9/rs4744599/72320296/[t/c]/tttgaacatatgtacattgtataagcataagattaattacaggtagctt atgatggagac[t/c]gtacaggaaggcccaccagagattaaatctgtgcagtttttctctatgtacaggtgccag/c//-/ 112/7/rs940871/6630195/[g/a]/gctggggaaagaatatctgagacgacgtttgggagcaatgctctttaccac gttcaccaa[a/g]tcgtctggggcaggggttgtgagctgcagcagttgctggtgccttgtgggaaggtggggc/g/DKF Zp547K054/hypothetical protein DKFZp547K054 113/21/rs2836544/38884994/[a/c]/gaagccaaggaaggacattcagtaagatggaaagttcagtgtcgcaac tgcagagagatt[c/a]atgtccaggagaaagtcattcaaccaaccatacgcattgagaacaggtcctggatttggc/c/ ERG/v-ets erythroblastosis virus E26 oncogene homolog (avian) 114/6/rs6921573/167186435/[c/t]/ccaactgatggtgacagcaggaaatgcacctgccctgccccctcgccc 50 (48) JP 2010-88432 A 2010.4.22 ggatactttcta[t/c]tctgctatgaaaaacagagtaaaatttgagaggaaagggaaagtacccccgtagccacaa/t/ RPS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2" 115/3/rs3903470/24483025/[g/a]/tgcagtatctccaaagtgtgcctgtagttgagattggagggtactctaa acaagaattag[g/a]taaatgtgtgcatactgaacacggagccagcagaactcttccccactgggtttccggaac/g/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)" 116/2/rs4666143/29026495/[t/c]/gcttgagtctaaggtccgcatgagcctggtttatgaaagactgagaggc ggtccatgtgg[t/c]gcatagtgagaaaaggagattaaagcagaaggtagcgagcagtcaggttgcgtagggcct/t//117/2/rs4632299/28965606/[g/a]/tgtctgcagttggagagttagactttcccaggcttgtggttttaccaag 10 gcaggaacatg[g/a]tatgagaaagaggcaggggaattgagggttataattatatagtttaagttacatggagag/g//118/8/rs9297285/99480291/[a/g]/atgcagggagctggccaaaacgcctttctctgtgataaagaggccacag cgttaaatccc[a/g]tgagttcatcaacaggtaacaaaatattttgcatgatttggccttgactgaaaggaaact/g//119/17/rs4606773/16937119/[t/c]/gtaagagggctgttgcatagaagtctagccttagagtaacacatttga attttggataaa[c/t]gggtggcaacggccatgctggtttccttcatatattgttagccttttcctggctgggaaa/c/ M-RIP/myosin phosphatase-Rho interacting protein 120/17/rs4985714/16894609/[g/t]/tggtggcagccctggggtgccacaggtggtggtgagtttcctccgtcc ctcccttgggcc[t/g]tgggttggaaggttcctggagtgctgcttctctgggacttgttactcctgtttgtgtccc/t/ 20 M-RIP/myosin phosphatase-Rho interacting protein 121/17/rs11078365/16879307/[a/g]/caatgcacaccatttctccaacagcttttcacttcaccatattttga gatggatggccac[g/a]tcaacactatctcagtctttaacaactagccccatggtactcccctgtatcaaagagcca/g /-/122/13/rs10507332/22991113/[t/g]/aatcacctcacaatatttttaatttgattctttactaagctgcttct agataagcaaact[g/t]ccccaattcactcacagtaaagcaaaaactagcaaatggagttactggattagtgtagac/g /-/123/3/rs4072181/135351487/[c/t]/tacaaggctgtatagtaggcaatgaccacctgctactatcattgctaa cacaaatgtgac[c/t]gcatcactacctgatgaaagccttttactgaatctacaaagcctccagaacaaagtctta/t/ -/- 30 124/1/rs9660662/201335343/[c/t]/ggtccccattttacaaaagacaaacctgaggatcagagaggttaataa acttgcaccaaa[t/c]cacacagctatggagttcacatctccctgactctacagtctttttccactgcacagtgct/t/ -/125/1/rs11582098/201349434/[t/c]/tgatctctgaatacccaattccatagcaggccctccaaagacactgg ctgaatgaatgaa[c/t]gaatgaagttctgtcgtttctacctaagaatttcttgagttatccttctcccctcacccc/c /-/126/8/rs10481092/98511712/[t/c]/agattgctttgcatgaacttacttaccgccacgtgaattccatcctta tagagcctttgg[c/t]gcttccctgccatgccaggtttctcttgaagaaaagtggtatctgaataagtatttacag/t/ -/127/8/rs2331465/98497948/[g/a]/aaatcgtgggaatttcagtagacctgacatgcagaggagatccagttta 40 ggggaataagc[a/g]tagcctttgaaatagcatagatctgagtttaaatagcagaagtaactagaaaatagttag/g//128/3/rs7611318/28259900/[g/a]/cgcacccagcctaattatggtacttctgaacttgaagtgacctttaaag taatctcatac[g/a]gatgaggagactgagaatgagagaggttaaagatttccatatatctacactttttgaatt/g/C 3orf68/chromosome 3 open reading frame 68 129/3/rs6445190/61045494/[c/t]/gagttttgaatacatttatatagttatacaaccatcacctctacatagt tttagaacact[t/c]ctatcaatccaaactgttacctcatgccctttgcagttaatccccactccccacaccagg/c/F HIT/fragile histidine triad gene 130/17/rs1155907/49657861/[c/t]/tattagcaatgcctattaagaaaagctctttaatcacccccacactag gggatttctcac[c/t]aaggccacttaattggtcatgtttctttggggccccactctttcctcatagctcaatttt/t/ 50 (49) JP 2010-88432 A 2010.4.22 -/131/18/rs8095216/3737306/[t/c]/caagtagtggtcaaacatgaaaatagtttgccaggtcaaggtaatattt tccatgtgtta[c/t]gtgctattatggtgattccagctgcatcgctttataataccaatgccaaaaatttcaacc/c/D LGAP1/"discs, large (Drosophila) homolog-associated protein 1" 132/19/rs7257560/48558663/[c/t]/gcaggacacccagggatctagcgtgggggaggagaggagcctaatgag aaaatgaccatc[t/c]aaagcctgcccttcattggtctggttcacgtctccaaaccagcttggatggtagcagaga/t/ CD177/CD177 molecule 133/15/rs8028632/73108315/[t/c]/tctccctcctcgtgagacctcatggttgtcttgtcagtcaaatgctct gaaaccccattg[c/t]ctgaagctctaggttcaaactttgctccttcaggtgttcagagctgccccaggggccccc/c/ PPCDC/phosphopantothenoylcysteine decarboxylase 10 134/12/rs12579591/52382855/[a/g]/tcctggagcccactgattggcggctgcctgctgcagggccagctagg tttatggctttgc[a/g]gcagctggggagaaaacgaggccagagacagaaaaatggaaacctatcaagaaatcaagg/g /-/135/1/rs2095904/9369958/[g/a]/tctgtgtcacgacgtgggtagaagctggggccacaggaggctttcactcg ctcctcttct[a/g]acatcagtactattgaatacttgggcagagaggcattttcttcttgctttgtgcactgtt/a/-/ 136/3/rs3732410/122898410/[g/a]/aaaaggcacaggagaaagaaagacatctcagggaggagctaaagcaac agaaagatgact[a/g]taatcgcttgcaagaacagtttgatgagcaaagcaaggaaaatgagaatattggagacca/g/ GOLGB1/golgin B1 137/3/rs7153/122865987/[t/c]/gctcattctgtgttttacgggccatctatagacttagttgttactctttgg 20 accactccc[t/c]tcaaaacttggaattctctcacctctaacatcagaacatcaattccagtggaacagtctt/t/GOL GB1/golgin B1 138/18/rs12456229/73247400/[a/c]/tgttttgctggcagtgttgtctaaattctcgccactatcactctttt gaaattactacag[c/a]tttatagtaagtcttgatatcccttttataaaattgagcaagatttattctgagatatac/c /-/139/6/rs6459184/57267994/[c/t]/ttaaaaaacttcacccaaaaagtcatccattcaagagttgtttttctcc accccagctga[c/t]gtgacaaaatgctgccaacaattttgatgccaataatgacttctacatattaaatacttc/t//140/9/rs4842153/136787135/[c/t]/catggtgtcggggccatgcatatgcgtgtgttttaaggcattaagtat gcccagaagatc[t/c]gctgcagaagaaaagatggtggtgagagaggggcttggagctgaggggtcgattccaaag/t/ 30 COL5A1/"collagen, type V, alpha 1" 141/17/rs726099/66901496/[t/c]/agtcaggtaaagtataatgtatacgtatgaataaagtcatacattaatt attgtgataga[c/t]attaatataatgtccaaaagcagttaaaaatgttcaactagttcaaaactaacatatata/t//142/10/rs4750895/128727058/[g/a]/aggtcctgggagcactcagcttctggaattctttactctgtaattgt ttgtggttctgat[g/a]ttttctgcagtattaggctcttctctgctctcagataccccacaatttgctggggcaact/g /DOCK1/dedicator of cytokinesis 1 143/12/rs10492255/107347877/[c/a]/tgcaggaatccaggtgggagtttcaactgttcccttcagatcccca ctgtgatcgagtga[a/c]tttccagactggatccaatttccaaacagagctgacatgtatcgggcattcggcagcaac/ c/-/- 40 144/18/rs4798124/3736998/[a/c]/atactaaaccctgagaatgtgataagcaaccactttttgcagctgcact gagggagaaac[c/a]aaattaagacagatctagaatataacatcgaaagtaaatctcttattgcattttactgtt/c/D LGAP1/"discs, large (Drosophila) homolog-associated protein 1" 145/6/rs4605857/162485708/[c/t]/tgtagcttcaccactgcagagggggcataatgacagcttacatagttg atttcaggaact[c/t]ttggtagttctaattgactgctgagaattgcaccaatttttagcttggcatgagcaaaaa/t/ PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 146/9/rs3922914/136738552/[g/a]/caggctggggaaggtgctgggacaggggctaggcgggtccaggtcacc tgtcacacacgg[a/g]agggacactcttgggccctctgcccttgctaacagcttatgctggctcttcctggaaggt/a/ COL5A1/"collagen, type V, alpha 1" 147/1/rs11590405/201346887/[c/t]/tttgtggaaattgaagctcaatgtaaaggctgacatcagtataaggc 50 (50) JP 2010-88432 A 2010.4.22 ttacctctctggg[c/t]gcctgcttctcatgattttaggcttttgaatttacctttcattcttttccagtttattaa/t /-/148/2/rs1124134/216526229/[a/g]/acagccaaaaatgagtttattggcataagccaatcagtgtccactctg agagctaagact[g/a]taactgttctgcaagggaaagtctgagtgtacttaatagattgatgggagaaggggataa/a/ MREG/melanoregulin 149/13/rs1855286/46644653/[c/t]/cccttcattggttcaccaactcttattaatgctacctcctagattgag tctcctaagtta[t/c]tttcctactggtctctttctgctgcagtttactatagcattgttccaataaataactttc/c/ -/150/6/rs9349851/57237036/[c/t]/agttgctatggaagtattttagtgttttctgcagtgttgggtggtgcag tacctgaagcc[c/t]tctttagtgtgtatttataatgacaccaagccatgaatttcattttagtggtagctttct/t/- 10 /151/7/rs1029482/43221135/[c/a]/ccaggaccctggccaggaagagcaaagtgggacagaagaggcaggtgca aggtagcctac[a/c]ccttttgggtatttattcacttactcttcctgctctccttgggtttgctttgttcttttt/a/H ECW1/"HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" 152/8/rs6468553/98446725/[c/a]/ctattttcaaacactggagtccattaagttttgcaacttccaggggaag ttttgaatagt[a/c]aactgcattaattttgatcaatttcagctcttagcccagcagcagctacccgtccctcac/c//153/3/rs9865213/176475733/[c/t]/gcccattccaattttatttaaatagatatttgcccattaaagacatac aaaaagtaaacc[c/t]agacaatttctaagaatgtccatcctaatagcttgataaagaatatatattcatatagaa/t/ NAALADL2/N-acetylated alpha-linked acidic dipeptidase-like 2 20 154/14/rs7144864/94775357/[c/a]/ctgaacacatcactcacacacccagttagcagacattgatgactatac tcaggcataaat[a/c]ctaagacatagacctcatgggcttcctttggcaggtttgagaagaaggaatgaacgcagg/a/ CLMN/"calmin (calponin-like, transmembrane)" 155/2/rs9752743/1605399/[t/c]/ctccagacccatgacctccattggccggaaaactctcaccgtaaatatac aaacatacta[c/t]ggctgccacgtggatccagctcccaaagctgcacgacatgcaacctgcccagttgcaagt/c/-/ 156/10/rs7084670/26136884/[t/c]/tggcctttattatgttccagggacttttgaagtgtttcacatacattg actcagttactc[c/t]ttacaatgaccctgtgaggtctctactgttactatctccttttacaaatgaggaaactga/c/ -/157/4/rs6854741/186114023/[t/g]/gggaggctgggtggtcacgcctcagtgccagccactgctctcagttct 30 ggtctttacgct[t/g]caggtcatgatagtatctaccacactgggttgttctgaacatcaaatgacctcacacaaa/g/ -/158/11/rs2450129/77618033/[c/t]/gtagaacacaacctggcaagttctagaaactcgaagctgctcaggctg cagcaagcacat[c/t]agaaggcagggctgagagaagacactggaggccaggccaggactaaagggaacggggagc/c/ GAB2/GRB2-associated binding protein 2 159/11/rs1893447/77650830/[c/t]/ccttcagagaattatgtagatctcataattccctaggcaaaactggag ctctttgaatcc[c/t]agcctagccatccacactataccagtttaaggtgcaatcttgtgattattgccgctgatc/c/ GAB2/GRB2-associated binding protein 2 160/18/rs4891429/66989691/[c/a]/ggattgcctggagaactagggaactaggactttcaggaaaaacaaatt aaggagcagtgc[a/c]aaaatatttagggaatgacaatacaagaatatgtgaagtacaattatacttgcttatact/c/ 40 -/161/2/rs10196805/67169754/[a/g]/atattgatatggcagaatttgtctattttactgttgttggacatttga gttgatgagtcc[g/a]ttgaattttgtatctttacctaatagatgtgcttcattattatttctaatagttttccta/a/ -/162/15/rs735982/25557339/[t/c]/tgctccacttcagaatatttttaagttcttttgatattttaattttagt taattgaaagc[c/t]agtatctcgtaactcaatttcctaaatcccttgggtgttttttttatttctcttgattct/t//163/11/rs7107174/77675584/[t/c]/cccatgatacaaaaatgaaaaattgctgttggattactgacacataat gcaaggagaata[c/t]gggacatgagtcctgaatatgctattaaagagaaagctttttcaggactgttctaacgtc/t/ GAB2/GRB2-associated binding protein 2 50 (51) JP 2010-88432 A 2010.4.22 164/2/rs752939/67164673/[a/c]/gtaaagccagtaggattcttgtttgagcaaaagcaactctggcagagtgt tgtaaaataa[a/c]agcacattagctacttggaagcagtagcacggctccagagacttcaagaatgctggaaga/a/-/ 165/13/rs7986263/52570948/[g/t]/ttaagtttattggaaaagagctggaagcttctggacagactcagtagc tataattttttt[t/g]tgtggagatattcatttaatgttaactacagtattgctgtttaatattcatagactgtaa/g/ -/166/9/rs4135183/112055423/[a/g]/attgctatacttctatgtaccctgctgcagctctccccatgtctccac ctctagaggtgg[a/g]gttcagggatttgcataactaaaaaatttatgaaagtgttgtcctacctttctcaggaac/g/ TXN/thioredoxin 167/10/rs1897584/78275322/[c/t]/taagaaagactttgtttcattgtttgagagccagctcagcatcagtac 10 agttgaacgctg[t/c]aggtttttaactcccatccctggtttctgtatggcatctctggacccaccctgggcctgg/c/ -/168/11/rs1783598/72529111/[g/a]/ctttgaatcttttttagaaatagaagacaggctcttttaaaactgtag gaagacctagac[a/g]tggattgagcttgtgcatgaaatggaatgactggcagtttattttgcacgtctttagttt/a/ FCHSD2/FCH and double SH3 domains 2 169/6/rs421453/149818402/[a/g]/tcccagaccaaccggctatggctggaggcagagagggacacagggccac aggcacaaacc[a/g]ctcagctaatggtgagggcagacactggcaaggtggatgagggtctggagacccgagcag/g/Z C3H12D/zinc finger CCCH-type containing 12D 170/19/rs1270290/39983838/[c/t]/tttatcagtccttccacctctgtgtggtaaacatgagcaccttctcca tatcacagtcag[c/t]gatctgaggaagttgtccagagtatctcagtctagtgagcaggggcaggatttgaatgca/t/ 20 -/171/10/rs7916535/25217750/[c/t]/ttggtaagccataaagtaacataatatataatatacatcaataatgtg gtggtatctcta[c/t]ataactcaacacagcaaaacttaaaagcaggcaatggtttccagatgcaatgtggaaaaa/t/ PRTFDC1/phosphoribosyl transferase domain containing 1 172/21/rs983475/18848364/[a/c]/aaccagtatttttctcttaaatttaattttagcagccagattatgatat cactgactttc[a/c]tcatgctgcacatattaaaatgtacaagttgacaagttatgacctgtgtatacaactgca/a//173/17/rs7208502/76284923/[c/t]/tattaatccaagtaagcagaattcccatgtagattcattccacagcct tttcttgggtga[c/t]gactctgtgcccagaagcaaggggctgactgggacctgagaggcctcttcttagtggcca/t/ KIAA1303/raptor 30 174/5/rs1560178/6220165/[g/a]/tctatcagagaagctctagg[a/g]gacctcaaaaccaggaaatgatttc ctaggaaatgctttaggagggatagcttccgaggt/g/-/175/9/rs3118545/136488413/[g/t]/gctcgggccagctgccggccatgctccagcccgacagcccaccaacag gggtctctccca[t/g]aaggagggaagctgtagctgggagagggggtccctaactttggacatgctgggttgtccc/t/ -/176/8/rs2976044/57149291/[c/t]/aagcttccggaagctgcctttctccagaagtggcagaccatttttggct tattgttcttt[t/c]tcatgtatctaataataggcttttaaggataccggaaaaacacccgtggagccggaggtg/t/R PS20/ribosomal protein S20 177/7/rs314300/100212023/[c/t]/tcactgtcactatttgctacttcatcgctgggcatcattagttcgtcct cttcctcatca[c/t]tgaagttcccacacatgccgcagacctggcgggggagagtggtttttcggtgctggggaa/t/Z 40 AN/zonadhesin 178/6/rs11751090/118111891/[g/t]/ctagtaggtagattaggcaaattaacttctactctactctgttttct tctaatccatatg[g/t]gtggcttctcctctgttgtacttccaaatgttgtggtgtcctagagtttggagctgtatg/t /NUS1/nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 179/6/rs515077/8125285/[c/t]/attctaaacaggccaggtttgtccttggtgcccttttccaaaggctctatt tggcgttat[c/t]gtccgtggaatttgctaagcaaggcagaaagatggagggctgtaaggatgtgtgatcaca/t/-/180/7/rs7776707/104392766/[a/c]/tgcctcttagtagctgtgtaatcttgggcaagttacttaacctctcta gggctcagtttc[c/a]ttacctgtaaaatggaaataaagcacattcttccaggccaggcatggtggctcatgcctg/c/ -/181/16/rs396679/61219805/[a/g]/tataccctattacattgtatagtaatcactctgattttccgctcatgca 50 (52) JP 2010-88432 A 2010.4.22 cattaacaaat[g/a]ttaatgtcttatttcctattaatctgccttttgtccattgattttcagtaaaccttcata/a//182/5/rs4958144/133049489/[t/c]/cacaccctcactgtgtcccagccgtgtccctgaggcttatcagctctg acatactcccga[c/t]tcatttatttttcttattcgccacacaatctcttctagaggggcatcatttccctggcaa/c/ -/183/5/rs3756450/1501148/[c/t]/cacctgcctgcacccaacgccctgagcccacagcagccatagcagcaacc acaatgataa[c/t]aaagccgacttggcatttagggcaaagttccaagcatgcaaaggtcggccgtttgatcag/t/-/ 184/9/rs895191/137485733/[c/t]/tcataagtaattcacagagttttaaagggaattctattggtgaaagccc cacagtgcaaa[t/c]ggagatagttcaagttgcacaagggcttctgggtgcctcactttcactgtggaagaacta/t/- 10 /185/4/rs2636767/142284981/[c/t]/aagcgagcaaatagagtttgacaattgccaaattaaagactaattcaa caaaacacagtc[c/t]ttatcagtgtggcatagcttctggcaagaagattggaaagcttagtctgatatgtgctag/t/ -/186/10/rs2960374/86605061/[t/c]/atgaacatatccagcaaacctgaaggtaaccttctgcctgtttatcat ttcatcctctgc[t/c]tttccaactccctattcccaggcaagtactgatctgctttctgttactgtaaattactct/c/ -/187/4/rs4443298/36323612/[t/g]/ccacatccagaaggaaggaggcatgctcagagaggccaagaatctgaac agacagacctc[t/g]ctgggttttcccatttagtctatgagcattaggccacactcttgtgaaaggaaaatatct/g//- 20 188/19/rs705507/43302561/[g/a]/tagacatcttgtgggttctgtagctaggttcttcctctggaaggtttgt gccagagatct[g/a]tggatcttcatgctattaccttggaaagacaagagatacttattaaccttggacactgat/a/S IPA1L3/signal-induced proliferation-associated 1 like 3 189/3/rs6800659/28245673/[g/a]/ttgtcacagatgaagttatgtcccctgccttaaagctcacatgttgaag ctgtaaccctc[g/a]atgtgactgtgtttggagacagggcctgaaaagaggcaactaaggttagataatgtcata/g//190/17/rs6565478/76306599/[a/g]/ccctctctaggtaggatgagctttgctccaggttacctgcctttcctt aatttactgaac[a/g]taaagttggagttttatgtggttttgcatttttggtttaggataatttttaattcttcgg/g/ KIAA1303/raptor 191/19/rs1725474/43276212/[t/c]/aatgctcatatcccatctgctgggagatgcaggtccactcgagactgt 30 ctgcttggcggc[c/t]ggggacggccatctggggcaggctggctggcttggaaggcagcccagacctctcgctctg/c/ SIPA1L3/signal-induced proliferation-associated 1 like 3 192/11/rs483884/95551040/[t/c]/ctcattatggcagccgacctcggtttatcacagagtcgaggcccacatc tttgatcctcc[t/c]cataaaactgtctgagagagttgcacaaacccacggatgtcttttattgtttttctaatc/c/M AML2/mastermind-like 2 (Drosophila) 193/9/rs11103479/136750244/[t/c]/gttcaggggctcagcccgggaagccaagacgtggaacaggagaagcc tgaatctgccagg[c/t]gaattgggcaggtgcctgcccctgctcctagggctgtgtgggtgatgggacaaagttttg/c /COL5A1/"collagen, type V, alpha 1" 194/22/rs6007662/44999709/[g/a]/gccgctgcatggagccgcatagatgccattgcttgaggaaaggtgggc tttagctgaggg[a/g]aggagtgaggggtggatggagaatgtctgtgtccatctggacactgggactgtttgagcc/a/ 40 PPARA/peroxisome proliferator-activated receptor alpha 195/8/rs10957057/59562894/[t/c]/actaaaatgagggcttagactagagaactttaaatagctgtgaatcgt ctgtgaagcatc[c/t]gtgctgctgtcttgacctcacttcacaggcccgagcctctgcgttggtatcaaccaaggc/c/ -/196/6/rs517924/109131382/[c/t]/tttatattgaactttaataagtcaaggatgcatattgtcatctttaagt ctagaagcata[c/t]atttaattccacagaaagagaagtcttgtgctcatgttagaaggtagtcttgatttgtct/t//197/11/rs2511175/77652729/[g/a]/gtaaggaaaatgagaacagcttttatttaccaatctaacatatctcca caaaattctcta[a/g]aaagtccaacattgtaactgaaaaaggtctgaattattattgacatgctgttgtgttaaa/g/ GAB2/GRB2-associated binding protein 2 50 (53) JP 2010-88432 A 2010.4.22 198/11/rs4945261/77667908/[a/g]/attatccttccccaaggaagataaaaatcacagaattcctaggttagg atatctagttca[g/a]gaatgactggctacataatttgcagagcccagtgtaaaatgaaaacgcagaacttcctgt/a/ GAB2/GRB2-associated binding protein 2 199/11/rs4944196/77686379/[a/g]/aggaggtcatggctggaacacagtaaacaaaggggaaagtagaacaag caaaaggcaggg[g/a]tagattgaagtttagattttatcttaaataaaatccctcaataggggcatgattaataaa/a/ GAB2/GRB2-associated binding protein 2 200/13/rs9572817/71333512/[c/t]/aatgtggagttcagaaagtaaagtatcatcataaccatgttcactttt gacaaaaataac[c/t]acgatattgtgagagactaactcttagaaaaacaacaggtttggaagagattatccaaat/t/ DACH1/dachshund homolog 1 (Drosophila) 201/1/rs3737696/15660856/[a/c]/gctgggggctcaaatggcctgaaccatgctacataaagcagccttgcaa 10 ataaccactat[a/c]ctggctgagacacaagctgtagtcaatcaatggttcagtgtgttggcccatcaatgtcag/a/E LA2A/elastase 2A 202/6/rs4441926/77337162/[a/g]/ttcattcagtcaataaatatttatggagagcaaaccaggagaaaaatag ttgtagtatga[g/a]gagagagaagtaattagattcaaatgatactcaactagaacttaaagattaataaaatgt/g/L OC643281/hypothetical LOC643281 203/7/rs6943159/11916586/[c/a]/tcaaacatattaggcttacactcacacaggctatatctcaaagtgccat ggtgacttgaa[c/a]attactcataatgactgaagagacctaattctcaaagtctgcaccctggccctaagatta/c//204/5/rs6868762/80548730/[t/g]/tgtctctaagatatcctgttgtttgaatatgccattttttttcaaacac gtagtaaagca[g/t]gggctgtcattttgtattatattctactgtgaaatgtgtttaaaattctgcgtattatga/g/R 20 ASGRF2/Ras protein-specific guanine nucleotide-releasing factor 2 205/5/rs271587/144455987/[t/c]/tcttcttttgaattttgtgaaatactctaactgaatgagaacaagaaaa gcgacagccct[c/t]tctctgatttttctctagagagacacctagtttcaaattcaagcagaacagatggttcag/t//206/7/rs310586/150524562/[g/a]/tgcacccggcactctgaccttcacgcatccatccattctctgcggtcag atacatggaag[g/a]accggtgtgagagcatacaccccagtcagaattatgactccgagaccctccgggaggaga/g/L OC392843/similar to IQ motif containing with AAA domain 207/5/rs2048451/90602964/[c/a]/aataatctttatgttgtctccaaatggttttcatgataattgtgatatt aagattaataa[a/c]aagtgctccaaggttcctcattagagcgagtttaccaagggtctaattggcataatagaa/a//- 30 208/8/rs4841380/10455449/[t/c]/ctgggactacaggcatacaccatcacacccagcctaacttcttcagatt tcactggttta[c/t]atgcctgtgggtgtgggtgtgtatcattctgtgcaatttcctcatgtgtgcagattcatg/t//209/6/rs7749023/42169711/[c/a]/acaggctccccaggagactgaggtttgtgtgcagcaagtttgctgggag tgccctcaaga[a/c]gcacactggcatgggagagggagaagtgagcacagggaaaagctgggctgcctgcacttg/c//210/3/rs4681141/149106957/[a/g]/gaaaatgcattgcctgaaaaaaagttgacatgtatgcctactgacttt gtaaactgaaac[g/a]gctaacaaatcttggaaatgattcagaattgcctctggtaatagtcatattattagttta/a/ -/211/22/rs4820242/35312621/[a/g]/caatctatataataaaatgcctcctacatgcttcataaaagtgatctg 40 agggcaatggca[g/a]tccttgtgctgttgggaaggggaggtggcagggcctggagcagaggcggggttgctcctg/a/ CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 212/8/rs6982054/56771942/[c/t]/gagggtagccaccctcacatgactcgacatgctgaagggggcaaccttt ttgtcttaatc[t/c]tgatactgggagacagaaagaaaattatcttaggatatgtaaacacaaattggccttaac/t//213/8/rs6474040/49202234/[t/c]/tggactgggaggcctgaggcatgagccatgccagcagcttgggcatgtt ctgcattttgt[c/t]actttcttccttcatccatgttttgggtccagagcacaacctcctctcctagtgcctgtc/t//214/12/rs10778632/107294192/[a/g]/ccttctaagaatcattgtgaaacacatcccagaatcaaccccctgg aggaagaggaagct[g/a]cattgtttgtctactaaattccattcgcctgactgaggatggtccctggggtgttaactc/ 50 (54) JP 2010-88432 A 2010.4.22 g/-/215/15/rs1562253/99911601/[g/a]/aaccttattcccagagacagtaactaagtcatgccatggggcaaagtg ggctttgcagac[a/g]cagttgaagttcaggagcttgagatggggtggtgatcctggattttttcaggcaaaaaca/a/ -/216/9/rs4977822/20921305/[g/a]/accctgggcaaagacatcaggaagctccttccttagctgagcacccaca gaataactaca[a/g]attttaactttgccctaacgttcctgtgtttgatagcatcctctttctacttagggcctg/a/K IAA1797/KIAA1797 217/22/rs2050140/35301903/[c/a]/atgctcttatcccatctgggatttgactcatcattaggatgaattagg atcattaggatc[a/c]atccgcattaggggatacagtctacagtcacagacctgcacagacctgctgggttgcaag/c/ CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 10 218/6/rs9390903/96684600/[a/c]/ttttaattaaatttcaaaaaaattaattttaccacagttgtagggctta gctttggctag[a/c]atcaaaattttatataaattacacgtcagttggaaacaaataatcagaacctcctcaata/c/F UT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)" 219/10/rs1002654/8488758/[t/c]/gctgtgagtgatgatgaccttaacttaagatcagagcgtgattctagta cattcaagagt[c/t]cagagatagtgacacacaacatttgaaatcaggactgtcccagaaatcctaggtcaccaa/t//220/16/rs7201164/61224753/[a/g]/ctcttagctccaaatcttggatacatgtagcaaattaaaatccattga attcatcactat[g/a]tcattatgcgcatcccatagttgctagctggtctggctttgttgtctccacctttcagag/a/ -/221/4/rs219481/109560129/[c/t]/gatctgctaagtgtcactggcaacatggtaagagttgatgatgtggtcc 20 aggatggatag[c/t]gtcttctcaaaattgtcttgcagctgctgcagattatctgtctgcttgtgcaccaggatg/c/L OC391681/similar to exocyst complex component 7 isoform a 222/18/rs999861/4629465/[a/g]/tgcctggaaaatgatcaatgtggagtctgcagaatagcagactgatgcaa tataaaaaag[a/g]gataatttcacagcctgttttttaaagtatagtgatactggttgtggggatggcagcatt/a/-/ 223/8/rs10282765/98480578/[t/c]/tgtccactgggaatgcatcctgctgtaagtaacaggcattccaactta cagtggctcaaa[c/t]aagtcaagatttaactttctcatattatgaaatatctgggggtagcctgccactggtgtt/t/ -/224/10/rs10795733/6083484/[a/c]/aagagcacagtttcatctggacctgcaggctggtgaggccaggagaga ttcactcagggg[c/a]cagtccaaaaaacagaacctggctaggaatttcaaacaggtaattttttgagaaagagtt/c/ 30 -/225/20/rs198493/35703480/[a/g]/ggttaggcgggatccagagtccccgcttttaaccaccacacaatcctgc ctcaaggaatg[g/a]aggattgtacgcatctaagtttcgaagattcagtgctcaagacttgaagagtctgcaatt/g//226/13/rs9517243/97726512/[t/g]/ttgatgaaatgaggaagcaagatgctaagaacaagacccatttctcaa ttattgagtgtt[g/t]tagagtctctgaaaaagatatttagaagcaccagagcctgctaattttgcctggggttta/t/ FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derive d)" 227/21/rs6518035/21324275/[a/c]/ttcttataattattcatggtattcaaatgtctaaaaattcctgctctg tagctgggggtg[a/c]aagacagcaacattgaaaagcacttgttatctggttttctttcctatttcttgaacattt/c/ 40 NCAM2/neural cell adhesion molecule 2 228/15/rs854158/48340369/[g/a]/gacttttcccgtggggatgctctctctctctcatgaaaagtaaatgagg attgtctaacc[a/g]gggttggaattaaaggggaaagagagtttttcttctcttattttctaggtggtggcagga/a/H DC/histidine decarboxylase 229/3/rs1870258/28365045/[a/g]/gagggagtgagaaaaaaatgacgtgtctttttggaccggcaacagctac ggaggttggcc[a/g]cggcattgcccgcatccctatcctccacccgtccctggcgagtcactcacccagaagcca/g/A ZI2/5-azacytidine induced 2 230/19/rs1386502/48985196/[g/a]/aggacagatccacagtattgggtctcagaaccacagacagcaactcaa ctaacggaggac[g/a]aaagacagggaaatgaagaaatgccatcttgaacagtgtggaacaggacaagaggctaga/a/ -/- 50 (55) JP 2010-88432 A 2010.4.22 231/14/rs1979352/97257678/[a/g]/tttcaaagaagtttttctgactctttcatattaacacaggctcttcct ctgcaatggacc[a/g]aatgtttctgtccccatcccccaaagttcatatgttgagatcctagactccaaagtaatg/g/ -/232/8/rs10903346/8438133/[g/a]/catcaaattcaggaagttaaccttgatacacaactaccatctaatcttc tgactctaccc[a/g]agtgtctccagttgtcccagtaatggcctttatagtaaaagaatccagttcagaatcaca/g//233/1/rs4442331/176039438/[g/a]/gaatgaaaacaatccctccctaaaactatcccccaacactgttcaggg accaaaacctgt[g/a]tataaaactaatgaaaagccacaagattaagattatgggaggaaaattgcgtttgaattc/a/ -/234/7/rs10266871/104599365/[a/g]/ttctgaacatttaaattgtgttggattagtgaagcaggaatctgacc 10 agatactgagttc[a/g]tgagattcttacccttctactgcctctgcacttgcttgtcctggatttgaatctcaaggt/g /SRPK2/SFRS protein kinase 2 235/16/rs4788700/71695425/[c/t]/ttccactggtctatctcccagtctcacggctttgcatggaagctgtgt gatggtggcctc[c/t]gaggaagaactggccaagtatctttgggacaaagtaaattgacatgttaggttatgaaat/c/ -/236/5/rs4701855/4433725/[a/c]/agtggggctccctgactttcctctctgcctgtgcaattctatttctttga catagaccag[a/c]tcccgtttgcattccctcacacactcagagctatctctaattcatggagaggaaaatata/a/-/ 237/7/rs4730037/104129973/[c/t]/atcctgttcttgactcttcggaggatattaatcagaagttcatctgtg tgccaggaaaaa[c/t]acatacgagtgtgttttgttttataattctcttctctgcattattttggattccttcagt/c/ 20 LHFPL3/lipoma HMGIC fusion partner-like 3 238/12/rs6539428/107375486/[c/t]/ttttcaaaggctgccgagcatttatgacatattgaatacaaaatcag ttcacatgcacaa[t/c]gcaaaatataatcctatttttgttccatatagagcattattatataatccctcatgtccc/c /-/239/2/rs7568979/56317890/[a/g]/tcactcagatatagctcattcacttccaccaaagtcagatatcctcttt agattactggc[g/a]tgtcttagagagcagaggtaatctactagtaattcaccaagattatccttattacaatta/g/C CDC85A/coiled-coil domain containing 85A 240/13/rs798993/31682082/[g/a]/gttcccttctgccccctagacacaggctatgtgtgctagtgatgcctct gtcatctcctt[a/g]ctctgagccttgggacgcagaaacctattgatatagcaggtggatatttttctagcagtt/a/F RY/furry homolog (Drosophila) 30 241/1/rs4661627/15658782/[a/g]/ttcctcaccctcttgcacaaaagtattcttgccttgagaaccagtgaat gttaatccatg[a/g]agagtccctatgctttgtgcttctgtttccctgcggaaataaggcagatctagctgggtg/a/E LA2A/elastase 2A 242/17/rs2013868/12053119/[t/c]/ctggcacttctgaatcgctttcagctctgaggcatcgatgtctgtgtt atttcacatcct[c/t]cgagctttctttctctgagccctcaagagtgttgatgactcggtatcttcagttcccagc/c/ -/243/14/rs12435663/97286657/[t/c]/agacccaggttatggaggctactggatgaagagtgcattctagtctc tgctgaccttaga[c/t]gctggttctaagtagttcattcatagtagaaactctgctcttttggacctgtctgatcaa/c /-/244/8/rs7005600/99482435/[g/a]/tctctccttgaatctgggtgggccttttgactgctccaactgatggagt 40 gcatataattg[a/g]ctgtgcaacttccaaaaagcaagttaggaaggccacacagcttccacctggctctctctc/a//245/8/rs9297284/99480263/[c/t]/tccagatccacaccgcctagggtcagagatgcagggagctggccaaaac gcctttctctg[c/t]gataaagaggccacagcgttaaatcccgtgagttcatcaacaggtaacaaaatattttgc/t//246/4/rs3212153/110828930/[t/c]/agcatcttccatgttaagttcctacaaacagtccaacagtcatcatca gacccattcaca[c/t]acaatcacattaatagaataacagatgttactttcaaggttcaattcttattaatatgat/c/ CASP6/caspase 6 247/15/rs516667/100021554/[t/c]/cacgataaagagcttttatcagaaaacagcaatagcatctcaacacag ttgggaagaaga[c/t]gaatatgactactatttgtattgttactcaaaattattctgggattacaaatacatgaaa/t/ 50 (56) JP 2010-88432 A 2010.4.22 TARSL2/threonyl-tRNA synthetase-like 2 248/12/rs10743683/9414199/[a/g]/ttaagtgaacaattcctaattcaaaagctacttactatatagttatac acaaagacatat[g/a]ctacaaaattattaattactaggaaaacaaaatgaaataatctatatgttatataataaa/a/ -/249/10/rs970654/33439740/[t/c]/ggaagagcgaggagtcattgtctctgagtcttcaagtttaggaaggacc ttgacacaggg[c/t]gatcggaaggagatggactgcacctccctgaggacgtgtcagcaggaaggagacacaaaa/c//250/10/rs7070343/33438257/[t/g]/atctgcacatgggccaatttccatttggtgctgaaacagttttataga aattgcaataat[g/t]tagcccactcgctgcatggacagaagctgcctatttcaagttaggtgttcattcaatttt/g/ -/- 10 251/10/rs2180563/33430188/[a/g]/ggcaaggaacaattggctattgaactctccacataaagatagacaagc at[a/g]agcatgtcagccccagactcaaggaaaggccataaatgactgtctcctgtgagaggccat/g/-/252/8/rs7827623/10578341/[g/t]/gttctctcaggaccccttcccacatctgatttctcaggttcttcctcca tcagctggact[t/g]actggtcagccttggagcccccagcatcagaggggacaaggtatgaggatggagtagcca/t/C 8orf74/chromosome 8 open reading frame 74 253/13/rs9518538/101227666/[g/a]/agcccctattctacctagatttctctggatgggagtcagtgcaaact tcttttgttataa[g/a]aaggttgtattctgtcactagtgagtaacggaggaagagcaattaagaatggccttttat/g /FGF14/fibroblast growth factor 14 254/16/rs3730119/3997604/[t/c]/tctcaactttccaggagtgagtcctctccagagagcaagacggagctgc gtttcaacaga[t/c]ggtgctttcaatctgtgctgactgtaacttttatccatcataggtttgaagacatacctg/c/A 20 DCY9/adenylate cyclase 9 255/8/rs2721884/133603447/[g/a]/atcctatctccctgaagtaaccaatgttattagcacatctttatcata attcacacaagt[g/a]tataaaagcatatataatcaggttttgtctttattttttagcaaattagaatcatatacc/g/ -/256/9/rs4978111/20745174/[a/g]/ttcccttttccctcaagcttttcagcttcttagaatcaatactgtgtat catcacctgca[a/g]tattgccactcagttctgacataatcaattatttggaaaacttaattatccagatgtcta/a/K IAA1797/KIAA1797 257/8/rs10808814/78063574/[t/c]/ttttaccaagagtaaaccttctttcaaaactggagtcaacagtctcaa accctgccattg[c/t]tttatcaattaagtttatgggatattctaaatcctttgctatcttttcaacaatgtttac/c/ PXMP3/peroxisomal membrane protein 3 30 258/14/rs1152471/55840906/[a/g]/gtccaaagtgaaaattcatggagagaaacctagaaaattacaacatca gcctctgtagac[a/g]cagctaaggagtctgcattttaagcaaacctcaggaaattctgatgtaagcttaagttca/g/ -/259/21/rs2300383/34171956/[a/g]/agagaccctcaaagctatagtggcactggctttcggtgatcttccaag gttcctattttc[a/g]ttctgttttcagcctctgcaaatttcttactttgtttctattttgtgtgtgtgtgtgtgt/a/ ITSN1/intersectin 1 (SH3 domain protein) 260/8/rs6471849/61297549/[g/a]/ggaaataactagactaataaaaagttttgctctttcagtgatttctatt aactctctaaa[g/a]actaacttttaaaatatagaccataaattagtgttggattctgtccatccttgacctttc/a/C A8/carbonic anhydrase VIII 261/8/rs11784742/61307700/[a/g]/gagttctctgtatgaattccttccttcttatttctgaacagaagcagt 40 gcttagtggatc[a/g]ctgcctcttaagtccagttttagtcctgatgaggaggaagacaactggagggactcacag/g/ CA8/carbonic anhydrase VIII 262/4/rs1848067/83801589/[a/g]/gtgaaatgtaagtaccttttctctcttactgctgcaaactgctgacagc aatgtattatg[a/g]gacccctcgtcagttgacagttgaagtggaaatattgttgtaagtaatgaatttgttgat/g/S CD5/stearoyl-CoA desaturase 5 263/4/rs993380/83803520/[a/g]/taaaaatttaacaaaattcttgaaggtcaatatgggatagcctcaagcct cggacacaaa[a/g]gagtttgtattcacactcaagcttttctttagggcccctaactgggtgctcacaaggaag/g/SC D5/stearoyl-CoA desaturase 5 264/14/rs178193/26042824/[a/g]/tgaacctctttccatgctgataagtaaagggctacgttataaatttaat tttggtttatc[g/a]tgatgaatcagtttatttagctaacctctggatgttgaaccctaagtttaatttttatat/g/N 50 (57) JP 2010-88432 A 2010.4.22 OVA1/neuro-oncological ventral antigen 1 265/22/rs5752867/27843729/[g/a]/ttgttatatcttcagttatataaaccatgaggaacaaatggagaaagg gaaaggacttca[g/a]ctgatagtggagtgattcataaatcgataacatagatggaaaactaaggtccacagagat/a/ KREMEN1/kringle containing transmembrane protein 1 266/4/rs7687544/92783113/[c/t]/aaacttggaactattagcacttattattaattattattaaccactaaca aaaactctttg[c/t]tgtaggtggctgttccatgcattgtgggatgtttagcttcatcttgtaatctacctactt/t//267/1/rs12406116/107245624/[c/t]/atcagaaaggaataagtccaggaagacaaattgtgcttcttatgact ataagagatgtag[c/t]gctcagtagagtgacattacttttccagcaaaataaatcagagaacctcccccaaatatt/t /-/- 10 268/4/rs1433378/130535969/[g/a]/tgaggagcgatagtggggcagaggcactccacagtcctccatggaccg gccctgactcca[a/g]ccatcattgtaaatgtgaagtgctccttggatccgattttgagggttttggttttaggat/a/ -/269/16/rs4784274/50011624/[c/t]/ctgctctgaaaacttttgcttccaattgtaggaacaatttcctttcaa ccaggagtaaag[c/t]cttcttagcaactaagttatgatttaattaacttttcctttacacttttacaacctgctt/t/ -/270/12/rs17041200/94541568/[t/c]/ctcttattaactagggctgccttggcagctcccaggggtgctgtgtc ttgacaaccttct[c/t]ctgtttttgtgtttggtaactaccccaccccaacccctaccctctaccgcccacgcctcc/c /-/271/3/rs17632548/178765503/[c/t]/gcccacctgcttttattaacagaaattctaatatgtctctcttggac 20 ctcctgtcaacgc[t/c]gatttgtccaaaatgttccaaaatctactcagattaaagagtgccaatccctgatgctct/t /-/272/13/rs7319370/46658052/[g/a]/aagaactgcaggagaagagacctggcaattgtgtataaaatggattta gaggtcatttag[a/g]aagttttagagttttccagggcagaaatcacgaggaccatggttgtagccagcagtgaaa/g/ -/273/13/rs359361/64137409/[t/c]/ttacattatagtttggaattaatataatgtgatcaatgatttaaattag gaccaggtaca[t/c]gaagaggactcactcaagatatggaagaagttattgagcattaatgtgaggatgcagtac/c//274/20/rs6090041/62183120/[g/a]/cccacagggacaagaggcaggctgctacttattcagcccacataacac tcctgagcggtg[g/a]gcacaggtgaggtcagggaagctcaacgaagatgggccagcacctggcccaggccacaca/a/ 30 OPRL1/opiate receptor-like 1 275/11/rs7102217/119692643/[t/c]/ggccctcctgcctcagcctcccaaaagtgttgggctacaggcatgag ccaccatgcccag[t/c]tcagttcattactctagtttctagaaaaccaagcaccttttctttgtggagactggagaa/t /LOC649133/hypothetical protein LOC649133 276/7/rs4517051/104109524/[g/a]/tattctttcaacaaatatcatcctccgaaccttaaagggacaacacta gggtacacatag[g/a]ccagatcctagacaggcagtactggtttacattctcatatatgtccatgtgacttgtgca/g/ LHFPL3/lipoma HMGIC fusion partner-like 3 277/17/rs4793980/44168530/[a/g]/ggaaaaaaatggtccataattcatccctaccaagtcctatccaattca tggtgctcatgg[g/a]ttcccactcctgagtgccacaaaagactaccctcttggggctcaatgaaggcttgaaaat/a/ -/- 40 278/12/rs12425076/107387600/[c/a]/gggtgcagccaagatgggatgagagtgcacaggtagggtgacaagg gtgtccatgcatgg[a/c]aggggtggcagctgaaacaggagaatcgttacattgaccactgagtataaatggatttct/ c/-/279/15/rs969564/37327093/[g/a]/tatattatctattttttttaattttcagaaaccttatttttttccccaa atttggaaaga[g/a]aggaataaaattcagatattacagaaaaaaatctcaaggaagcaagtaaaaacaacctgt/a//280/13/rs945373/19712559/[t/c]/catagggtctgaataagcctttttattctatgtgcttcctttgctctcc tgttctcgacc[c/t]gtcttggcacctgctgccctggcgccctctcggcagccctccctatgggcctgcaccttc/c//281/5/rs4868200/172080787/[c/t]/aatggctgctgggtaggcagccaacaagtgtccccagctcctgagttc 50 (58) JP 2010-88432 A 2010.4.22 aaactttgaccc[t/c]gcctcttctgtcaccgtgggcaagtcactccacctctccaggcctcggtttccccacctg/t/ -/282/4/rs1378959/156239425/[g/a]/ctttccatacactgagattccttagtgtgagaagcacagatttaccct tcacttttgctt[g/a]taacaattcactcactagtaatgaagggcctcattttatgccatgcagagaactgaaata/a/ -/283/11/rs6592772/77693211/[c/a]/actcgatttcgccaagggccaggctcccaaggcaagaatctagagtag aagtcacattac[a/c]atcttagactctggagagacaaagaagaaatatttttcctgaagtttcttaaccaggctc/c/ GAB2/GRB2-associated binding protein 2 284/21/rs11910142/35738222/[g/a]/cctttgtgtggctggttacacagtgggtatccaggtagtaaggactg atttaatttctcc[a/g]tgattcaggcttgtccagacatttgtcctcaagctgtatttgagggcagcaaggataaag/a 10 /-/285/18/rs4239384/29910347/[g/a]/catacggagcggccaggaggaaccatttctgacatccaccaaatccct cacattggcagt[a/g]gcctattctacttactccaaaggtcatcctgaatagtgtaaatgattatctaacaatgtg/a/ NOL4/nucleolar protein 4 286/18/rs9961162/29884418/[g/a]/tcttagttaaaaatgtgttgaaataatttactgctataatagataatg ttactatctgct[a/g]ttcctttaggactgactacctggacatcgatcatattatatattgtctagcttccccaag/a/ NOL4/nucleolar protein 4 287/13/rs9506903/22150146/[c/t]/ctcaatcttaatctggagagaaagatagtacttttattaactttatgt tggataataata[t/c]aatggtggttattttaacagctgaaatgttctagtttcttagggtcttacctttatttta/t/ -/- 20 288/5/rs16885750/55910566/[t/c]/taattaggtactttgctatttaaggctttcaggggcaaacacacaaaa aattgttttgat[c/t]gagttacaaaataaaatcttaaacaaatgtacatagaatactcaagagtttattttaaaa/c/ -/289/12/rs1513047/17238712/[c/t]/aggttgctggaacatacacccttggttctctcccctatacatactttt ttattttctaaa[c/t]ggtctggctgagaatttacaaatcgtaatgttctgcttcacttttaaactaaaaattcta/t/ -/290/10/rs10509619/92859891/[c/t]/gaaaagcagcagatccactcaggtctctctgacatcaaaatctagct ctttccaacttgc[t/c]tatctatcagtgaaatagaatttgacttggggtgagcaggaaaaaggggtaacaatactg/c /-/291/3/rs1609729/28278115/[c/t]/taaaacaataaacaataaactatgggtcagaggggcctgatctgggaag 30 actcaaagttc[t/c]ggtggctctggtgtgcattttaaacacaacttccaaaattggactaaaatggcaaattga/c/C 3orf68/chromosome 3 open reading frame 68 292/17/rs11079321/53102415/[a/g]/cccaccacaccaggagctgggtctagggctggaacttggtgggcccc tggcttgttccaa[a/g]tatgtgaactgagctcatctggaaaagattttgtaaacatttgctttctctgaatcggta/g /MSI2/musashi homolog 2 (Drosophila) 293/6/rs10499303/155656931/[t/c]/tactatttttaacatatgggtcccaactaacctagctccatttactc acaagtcagccct[c/t]gttgatccctgtcagcacctctgtcagcattggtctggttagatacatcatataagcatt/c /TFB1M/"transcription factor B1, mitochondrial" 294/18/rs11873192/17548672/[g/a]/actgaaatttctgaaactagtcttgtggtttccaaattggccttcca caacatgcactct[a/g]gggaaaccaactgccatgtaagaagtcctactcctctggaaccagcatgctgtgaggctg/g 40 /-/295/9/rs12353255/20911332/[a/g]/ccttgtgctttttaattaggttaataacatcattttgttttaaaggac aatttaattaaa[a/g]cgtcggtggtgttgcctagataaatactctgtggaagctgacatgttattatgcaaatta/g/ KIAA1797/KIAA1797 296/20/rs7272324/10250333/[a/g]/aaccacccagctatgctgctcttgcatcctgattctcagaaactttgt gaggtcacaaat[g/a]tttgttgtttggggctgctgagtttggggataatttgtacgtagcaatagataactttca/a/ -/297/7/rs6959821/144882934/[a/c]/attaaggagttgatttgttgagtcaaaggtaggcatatctagaatttt actatattagat[a/c]ataccgtttttcaaaatggctgttttcaggtacattcctaccagcaacgtgtaggaataa/c/ -/- 50 (59) JP 2010-88432 A 2010.4.22 298/21/rs9631189/36391146/[g/a]/gagtcacacaaaactgcctatttttgttcctacaaagataaaagccca catccctcccca[g/a]gggtgctctctcacaatttgcccacaaggaaattccttgcaggccctaagatccttaccc/g/ -/299/12/rs7958583/9406321/[a/g]/tcagggattaataagtgctggggttttgttgtacagattgataaaactg tcgaaggccaa[g/a]ctgttgtccaaaacaggataatttcactagctttgagagtatttgtcaaaaatatgtttt/a//300/9/rs1342321/109261165/[t/c]/ggccagtgagtagatgagctaaagctggaaatcatcaagcatcagagg ccctaggaactt[c/t]actccaacaatctcttcttagagatgacattatcagcattatttaggaactgtacctcgg/c/ -/301/6/rs162989/155751623/[c/t]/gaatgactggttgatgaagcatggtgagcagggctttattcttgacagt 10 agcatgcagga[c/t]ctttgcctgtaagtttgtatagtttgcataaagtgggattaggcttaagcaatagtatta/c//302/12/rs1362599/14793360/[g/t]/actgactggacttctcagctccgttccaggcttaaattgatagcttat atttaatgctct[g/t]tgggctcttgtgcacctagcaaaggttggcatggccctggtcctggtatggaggctgcca/g/ -/303/15/rs1871017/25564086/[g/t]/aggtgtcaagaggaagagtggccatgctgggaacagggtggatgtgct cagtgtgaagct[g/t]atcgttgtgtaatttgtctcaaaggtgtacggagttttccatgtcatattttaacattct/g/ -/304/7/rs10252713/9529436/[t/g]/ttcccttccacacaggttatattcttaagaaataaatcccattatctct aagcatgtatt[g/t]gacacctatattattgggtcaggagttaggcctaacataattcagagttaagaagactaa/t/- 20 /305/8/rs2138248/133599217/[g/t]/atcttccctttgatcttccactcatagctaagggagctatgtactagc cacacctgcgta[g/t]gtgtaattttatataaatgggattatattagtgaaaacatgaataagaacattttgagat/g/ -/306/2/rs2244983/59739861/[c/t]/aaaagtaagtaccgtggctgtgggaactgctatactagcaatgagcaag tctctctgggc[c/t]agacatagggcccagcagcaatgagagagaatcttagggggtcggttttagagagtttcg/c//307/9/rs1417614/74485413/[t/c]/atctaagttctatattgctctcatttcctttttctctttgtctctcttc tgttgtagccc[c/t]tccctcaccgctaagccttcaccctgactctaccctgcccccactgccttttgttctttg/t/T MC1/transmembrane channel-like 1 30 308/2/rs10519086/67116150/[g/t]/tgctgttccccagaaccttccaagtgacttaatctcttaacttccaag tcacctagaaac[t/g]tttacctcagacagtttttaaaattgtgctttctcatctcttcattgaaagatacaagaa/g/ -/309/3/rs13094641/126874548/[t/c]/gggtttacagatgtgagcctcggcgcttggccaccatgcctttttta gggtggcctattt[t/c]atatgtgtacacacttctccgttttgaaatgagacgttcttacacccaaacagatcctga/t /-/310/2/rs6742549/231160095/[g/a]/ttccaggaatgcaagaattctttaacatttaaaaatcaggaaatcatg cttgtttcggca[a/g]cacatacactaaaatcggaacaatacagagaagattagcatggcccctgcactaggataa/g/ -/311/1/rs17108140/53455266/[a/g]/ttactgcccctggaggcctagtatgagacccaggaagaactcatcccc 40 ttcttagaggaa[g/a]cctgccttgggcacctgctccctatgaagctttctgtagacagcagacatggaggctgca/g/ C1orf123/chromosome 1 open reading frame 123 312/4/rs12501677/139015836/[t/g]/tgtgatttgctacattaaaaaaaatgatatactaaaggatgtaggaa gttcagagacata[g/t]actttaaaaagaaacatgtaaagagtaaaattttcctactgtattatgggacagaaagaa/g /-/313/7/rs314313/100261301/[g/a]/tgtgacacctattacctgagtgtttccaagcaccaggcctgtgctgagc gccttacaaat[g/a]ttaatttcacccatccagcaacgctaagggtggtgctattattgcccccatttttcagat/a/E PHB4/EPH receptor B4 314/7/rs1541506/156418773/[a/g]/agagttgcagattctgcaaatggtagactcagtaagtgcccacctaac caggaatgcagt[a/g]cagcaaaggctgttgtgtggcttgggacacgtcagtttcctcacccatgaaatgagggtg/g/ 50 (60) JP 2010-88432 A 2010.4.22 -/315/8/rs7003404/25927267/[t/c]/tatgaaatcagacagtgtaaaattctctccctgaggaatctggcattat tacatccccca[c/t]caatcatggcattgtttctccaacaactgtatcagaggcagcatccggatattgctataa/c/E BF2/early B-cell factor 2 316/15/rs10518754/52145747/[g/a]/aataagtaaagagttatagattgattaagatgatagctaatgctttt cctgtcttctagc[a/g]tgatggccagcagcctagcacataataagagctaagaaatacaagctgatttctttttcc/a /UNC13C/unc-13 homolog C (C. elegans) 317/10/rs315632/36512617/[g/t]/ctctggatgttgttgtgtgtggacatgatgccttgaactgctgcagcca gtttgcaaccc[t/g]gaagaaccagccttagaatgaacccaatttggaggaaattaattaattgcccctgccgta/t//- 10 318/8/rs1390027/62891127/[a/g]/ttctagagtttgtcagctttaggacttccaaccaagtagctaccagtag acagggaccca[a/g]gtgaacaggtgttattgctctagattctaggtatccaagtctggttggagcatagaaaca/g//319/6/rs10457181/109139465/[g/a]/gctgttcaattcttcatttgttgaggcaacacatttttattgagcac ttactgtgtgcca[a/g]gtgttggggaaaaggtgaccaagacaaaagtctctgcccacaggatgcttacattctgcc/a /-/320/15/rs1425268/59889274/[c/t]/gaaaatggagactcaacattcaaaggtatgtgctgaataactctgtct ggttgctaatga[c/t]accgtgatgtggcaaaacaccagctactgccgaggctcctctgaggagatctgtattcta/t/ -/321/9/rs10513311/119648541/[a/c]/tttttaactaaaagtacaaatcatcctgtgaaagaccacaaatagat 20 atttgcatttctg[a/c]agccagactagaagaccaaaatccatcaaaatccagaatgatggcaaatagtggtggaat/c /LOC100129489/similar to hCG28178 322/7/rs2299304/104559093/[c/t]/aaatgcctctccacacagcactctctaaattcaaagtgaccatcattg gccaccggttct[c/t]ttaaccgttcttttctatacctagctaaggcagggacttggtttttgatatggaagaact/t/ SRPK2/SFRS protein kinase 2 323/17/rs7501623/1724177/[g/a]/agagtggtgaaatagactctctaaagtggtaaataatcatttccttagg cttatatacaa[a/g]tagtacgttattcctctccctccctccacagaattatttttctggttgtctatctttgcc/g/R PA1/replication protein A1 324/19/rs379758/48990002/[g/a]/aaaaaatctattcattttccaactccttgcactacctctgccatcatct cttgcctaggt[a/g]tatcatctctgcctagactggggcagtagccacctcacaggtctagcttccattcttgcc/g/- 30 /325/4/rs7440527/7877724/[c/t]/tcatgttagagacttgttaaccctaaggggtaatacaaatattatcattc atattttcac[t/c]gtttattatagttctaagaatgcatttatatcatgatttcattctacccctttgaaaatt/t/AF AP1/actin filament associated protein 1 326/3/rs4455284/33246697/[a/c]/gatgatcacaaggatgatgtgagtggtgtatttatagtaatgatgggaa gctaagggagg[c/a]agggaccttaaaagggggaagaaattgggggtgggagagagcaaacaagaggggacctcg/a//327/2/rs3821053/97758319/[a/g]/agggcggtcaccactctactgcttgggagtaagcggccaccaaaacccc gcttccagcag[a/g]tgctaggagcaacatgacaggaaaaacacaacctaattaaaatggtagagttccttctca/g/T MEM131/transmembrane protein 131 40 328/2/rs7570009/97770115/[t/c]/gaattatctatgtaaaaagcatgtcctagacatttacttcgtctttatc ttcactacatg[c/t]tgtgtaatgaatttgtctgagctaggtgctctgaatgaatcgttagtctgagctagttag/c/T MEM131/transmembrane protein 131 329/2/rs718159/97785966/[a/g]/actgaatatagaaaggatgataaatcttaggaataataccaatggcatta atgtaatccc[a/g]cgtaagtttcgaaaaacctttccaagtataaattcagtaagaaaagctggcctatagtag/g/TM EM131/transmembrane protein 131 330/2/rs10209970/97989129/[g/t]/ggcacacaggcttgttcttcatggtcttgccttccctgccatagttaa ttggccatggac[g/t]cctttcccacattggcccaaccagattctcttgaacgttttctccaagaaatatggatgt/t/ -/331/3/rs1376338/64006946/[g/a]/cttgaaagtataaagacaatttgaattaagttaccagcctcacagggtc 50 (61) JP 2010-88432 A 2010.4.22 agaggagaaag[a/g]ggcctcagaagtgatatggctcagcctcccattcaatgcaggaagcccttttaaggcatt/a//332/14/rs7153837/24542222/[a/g]/tgacaaaagaagcaagaacagcaagatcagagaaaagctctggccagt ttctttctaaat[g/a]acctctgagctggaggggaggagaccagttgttaagcctaaaaataaaggaagctgtaga/g/ STXBP6/syntaxin binding protein 6 (amisyn) 333/16/rs7198017/86906435/[t/c]/ctctgaggtccctggggcaggggctggcacggcactggccccagacct agaaagcagggc[c/t]accatcctgtgtgtcactgttgggccacacatgcacacagacccaggaagtgggggccgt/c/ -/334/18/rs2980971/58225044/[a/g]/aagcaggtggggctgcgacacttctatcctctcttccctccctctagt tggacctgagcc[a/g]tcggaatttattttcccagagaaatgaatgatgcactgcccttcaagcagaagctgtgac/g/ 10 -/335/18/rs2957146/58228274/[c/t]/tgcagaaaggaaaataccttcatttctttcatcaatgacttcacggca ggaggtaagaca[t/c]ggttggtttctcaatcacgatatcctgtccctcaggaacatttgaagtcttagtcatcgg/t/ -/336/19/rs8111180/43322000/[g/a]/agtgatagtacctttccccacctctgcccgggcctggcatgtctacag gctctgatagac[g/a]ttcatattgttattgttcctcacctggtgcctggtgagacattggcagctgccagtccaa/a/ SIPA1L3/signal-induced proliferation-associated 1 like 3 337/14/rs242413/55697554/[g/a]/cgtgtgattctagtcatggaaccttaataacagtcttctatgccagacc tgtgtgacaac[a/g]taagttcatcttccattatcttacacatctctactggctgttgagaggtttcatatttct/g/P ELI2/pellino homolog 2 (Drosophila) 20 338/6/rs313156/86100864/[t/c]/ctcaacaattccatgctacccacaaccagcaccacccaaatgcaaccatc aaagtctagc[c/t]cagggcaaaagaaataagtcagacttggctttgtctaaaaagaaaaacaaatgaacttat/t/-/ 339/1/rs11247653/27862207/[g/a]/tgggagcgcaggcagtgagcctggaggtgagacctgactacaggagtt tggagatcccca[a/g]gttgtaggactgaggacttgaagggaagaggaggtgggccctggagggattctctgatgg/a/ -/340/9/rs1834264/87323818/[c/t]/aagttacccaaatcattcgttgccaggagagttcacttcatttagaact tggaaccacca[c/t]ggttttcaataggacgcttaatgaactgggccctacgaaataggcaaacttcctggcctg/t//341/9/rs12684637/136773364/[t/c]/ccctgcttttaggcagaagaggggaggtaagagaactcttcttgcgt 30 ccgtcgattctta[c/t]ttggcttcagcagaaaatagtcgttctgcaggggagtggcgtgctctgtcccctccgtct/c /COL5A1/"collagen, type V, alpha 1" 342/3/rs7636434/6273349/[a/g]/agctggacttggtggctagtgaacaaagtattttggaagtaatgctaagt gacttccaag[g/a]atagtcataggatgtgacttccaaaatcgattcttcatagaaagacccaaagtcacaaaa/g/-/ 343/1/rs6695327/172328467/[c/a]/tcatcctcctccttgccaccaacaccccctcctactgcccaaaaactc caggcaacaact[a/c]ttttgatttttatcactatagactagttttactagtcttaatcttcacacaaatagaata/a/ -/344/1/rs6689285/172286356/[g/a]/tgaaagttcatgagctgaaatattgtattttctttcatttcttctaga tacctacaggag[a/g]agaaaacaaactatgtttgaactgagaaggaacaaaagacctgtttactctgcaaactag/a/ 40 -/345/1/rs6677660/172281130/[t/c]/ttgctcagggaaactgatttaacaccttttcttttattgggagctcat ctttattctagc[c/t]ttttatttagaaattttcaagtacacataaagtagatagaattatataataaaaacctca/c/ -/346/4/rs17057610/173106767/[g/t]/acacacagacatacacacacactcactgagttgacatgacaataaaa aaagtattcagag[t/g]gcgtccaaaaaggaattgagaacaagaatctagaaaagtgacccaaagagtcctggcagc/t /GALNT17/polypeptide N-acetylgalactosaminyltransferase 17 347/15/rs488156/71412948/[g/a]/cttccagctacagccctgtagctagtggcaagctgttctgatactagtg accgaagatga[g/a]tactttttgtccacagctcatcacctgcagtcacccccacctgtggcccccatcaagggc/g/H CN4/hyperpolarization activated cyclic nucleotide-gated potassium channel 4 50 (62) JP 2010-88432 A 2010.4.22 348/13/rs553316/112886016/[t/c]/agtcttctttttgtaatttttatcggctgtcacggcatcattcttggt gatctcttctct[t/c]gtgctcaaaccagactttaaactcttcttcagctgtttgtggagcacacagtcccaagta/c/ PCID2/PCI domain containing 2 349/11/rs10899469/77695961/[c/t]/tacaacctctacaacctcatgtgcacctagagtcctagaagtgggtc ctttgcattattc[t/c]ctaccaaaggaatcaaaactctctggaaaggggttgattctatgttgtgaagttaaaaaa/c /GAB2/GRB2-associated binding protein 2 350/1/rs3766160/15681459/[g/a]/gagtccggctcgctggccgtcagtgtctctaagattgtggtgcacaagg actggaactcc[a/g]accaggtctccaaagggttcgtttctatctgggtgcacttgggggtgaggttgtcaggga/g/E LA2B/elastase 2B 351/9/rs2039389/20791595/[a/g]/gagaggctataccttgtaaaaagtcataataggggccatttttt[a/g] 10 ttttatacttgacatctatatgatcttccttgagtatcatttttgagcaaagaatggagt/a/KIAA1797/KIAA1797 352/3/rs167771/115358965/[g/a]/caatttcatctcttcccaggttgccccatacccttctcatgctccaaag tctatcacaat[g/a]atcctcttttccataaagccctttcacattcccacagtctgattcagtcacccttgaact/g/D RD3/dopamine receptor D3 353/5/rs268999/22662423/[a/g]/tctttgatatttctgttctttttatttagttttcttgctggtatcttctt tgatgccctt[g/a]ggggtttgattctggtataagggatgttaggtcaactagctttgattctggaagatttca/a/CD H12/"cadherin 12, type 2 (N-cadherin 2)" 354/1/rs1851736/77519836/[t/g]/tgaagggttggattccacaccatgatccccttttcccccttccccacag ctccctatagt[g/t]aaagatccgtaaccttaggaataaatgataaatcctgtgactattaggtttttcctggga/t/A K5/adenylate kinase 5 20 355/13/rs9518498/101155498/[a/g]/gaatattttttaaaagaatgtcagacattcctagtatcctgtctttc tttcaggatccca[a/g]ttttctccaggggagcaacatatgctggattaaaaaaccgctctcccagaccttctctgg/g /ITGBL1/"integrin, beta-like 1 (with EGF-like repeat domains)" 356/13/rs927987/101232344/[t/c]/ctctggctctcctttccaacttcccttgaataaaggtatcccttaaaa ttcagtacatgt[c/t]ctttttggtctatggagatctcattctttttgatgacttcataaccttaattttgcattt/t/ FGF14/fibroblast growth factor 14 357/14/rs2556611/80415919/[a/g]/aatgaaataattgctgaaaaccccccaagtcttggaaaagatacagat atccagatctac[g/a]aagctcaaatgttcccagattcaactcaaagagatcctcttcaagtcatattctaatcac/a/ C14orf145/chromosome 14 open reading frame 145 358/9/rs7853555/78642927/[c/t]/actagtttttatttttcctgatcttgacctttttttttctcttttatta 30 tactgcatgca[t/c]ttttgtaagcctcctcaaatattttatggaagaaggaagggcaaacataataaaatagat/t/P RUNE2/prune homolog 2 (Drosophila) 359/1/rs6681053/15207369/[c/t]/cctcggctgtaagtctgaagcccaggctgccagagtcgtggaggaaaga gttttcccaag[c/t]ggatgagtggccagaagtggcaggtgttacagtggatcctgctggactctgcaggtctca/t/R P1-21O18.1/kazrin 360/9/rs4742236/676753/[a/g]/tgaggggaaatggcagcatcacgtcataagtgcaatgattgttacctatga gcctatccg[a/g]taagggatctgagtgggcccaagcatcacacacgtgctggagctgagtgttctctgagga/g/KAN K1/KN motif and ankyrin repeat domains 1 361/3/rs11129315/28283335/[g/a]/aattaattgatttaaatataaaatttaattttatagtattctttcttt gctagtgatatt[g/a]ttggtggtgaataaagccgctaaaataaatgactgaagtatactggtagatattaacaca/g/ 40 C3orf68/chromosome 3 open reading frame 68 362/5/rs6450521/58846123/[c/t]/ggccccacttttctcagtggcctcaaaatcattttatttatttatttat ttttacctcac[t/c]aggatctaaatctgtttttagtggctttgaaaactgtttctaggactgaactactgaatt/t/P DE4D/phosphodiesterase 4D 363/10/rs7901504/125768215/[t/c]/accccttctcaccttgatccgttgcaccaggcatctttctaagatgc tgaactgccatca[c/t]tattgatggggttcaaggcacactgcccccaaatataacagcttggcatttgagaaaaca/t /GALNAC4S-6ST/B cell RAG associated protein 364/11/rs488925/83806185/[t/c]/ggattttcaaactgacctggaaggcaaatagatgattgtactggggaga aaggaaagtac[c/t]gatgagggactatgtatgatttaaagaaggctgtgatagtttgggaaagagatggacttt/t/D LG2/"discs, large homolog 2, chapsyn-110 (Drosophila)" 50 (63) JP 2010-88432 A 2010.4.22 365/11/rs543814/83817585/[g/a]/catcctcaactataagcttgtaatgatatggcatgtgggataaggcagc tggaaaatttt[a/g]gtttgatgtcattgttggtggctgaagaagactctggctttatgctagttactgtttgtt/g/D LG2/"discs, large homolog 2, chapsyn-110 (Drosophila)" 366/9/rs10970978/32432256/[g/a]/gattctggtatgcagcagtggttgagaaccattgcgctatagttcacg gttctcaaaatt[g/a]taagaatcactagccccctcccaccccacgctccctgcaagacattctgatgcagcagat/a/ ACO1/aconitase 1 367/3/rs3773678/115352768/[t/c]/tgttcagtcatggcagcagcaggactcaaggctcagcccctcctccaa ggtgcctcatag[c/t]taccactaacagcgaggcccttgtagacatattgtactagaagcccccggcagagtctaa/t/ DRD3/dopamine receptor D3 368/2/rs2971007/100549959/[t/c]/ggggaggcgtaagatgtttgcaatgtgtgggagtctgaggggggtttt 10 ctcaaaggcagt[c/t]gtactgtctgaattggagtcccttggagtgctggtaaccccacccacctagtgtttactg/c/ PDCL3/phosducin-like 3/ 369/9/rs872863/125194175/[t/c]/gtggagttcccatgcagatgacttcccgaaccccttctaatgtttggtt taacgtgtcgc[c/t]ggttagcgcgcgcgtgtgacagtggtgacaggcgaggctgttcctttttaaataccatgt/c/D ENND1A/DENN/MADD domain containing 1A 370/8/rs12679591/10421620/[c/t]/cgattccatacagatgttgtgggttgatctcaggaccaagaatgtggg ggatggatccca[t/c]tgatgcaaaatggatatgagaacttctgccagttcattctggagagttgactttggtgca/t/ UNQ9391/tryptophan/serine protease 371/6/rs259405/147145109/[c/t]/tgacttaatgattttaggttcagtggattcctatttgcctatctcgtct gaggacaaaac[c/t]gtgaaacattctttctccctgattccagaaaccatctagatactttgaggacattccttg/t/C 20 6orf103/chromosome 6 open reading frame 103/ 372/17/rs4969266/76376141/[t/c]/ccattcttgtacatttttgctgagtaggtttagaatgatatctcgtgt agcctggatttg[c/t]gtttctctcatatcgcatgatgttgaacatttcctcacgttcagtggccatagttatgtc/c/ KIAA1303/raptor/ 373/11/rs10834430/24660091/[g/t]/aggtactttggttaaaatgcaaaacatctacatgcatgcagaaacat ttgtgggttttct[t/g]tagccagaaagaagagttcttatactatcacaaattatttccattgattttccttatcta/t /LUZP2/leucine zipper protein 2/ 374/18/rs1075892/42547212/[t/c]/ggggtggcaaagaaagtggggagaaggagacagacccatgaaatagtt taggaatggaac[c/t]agcaggatgcattgataatttagaaagtgaataaatcaacagtaactcctaggacttcag/c/ ST8SIA5/"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5"/ 30 375/17/rs1485330/76255417/[t/c]/ggaacgccttcctcccggggttattgggaaaatccaggccctgatgaa tcagtgtcctaa[c/t]cacacagaatgcactcaacaagtgccacctactgcattccttgagtagacaattcctgga/t/ KIAA1303/raptor/ 376/1/rs9425349/184166077/[a/c]/gcaatgactataacagcagaagtcacaagtgagtgcccctttgaactt gaaagagaggac[a/c]ttttttttctgggttagctgttgcctagtacaccagcctttaagctccactcacttctga/c/ HMCN1/hemicentin 1/ 377/11/rs10899496/77801479/[t/c]/atgtttaatttttttaaaaagcccaggctttaggacaaagctagatg actttgggtaagt[t/c]gcttcccttattatagggctaaattactacattaaaagatcaatggtctaagcatagtgc/c /GAB2/GRB2-associated binding protein 2/ 378/18/rs10502622/29538006/[c/t]/ctactaatatgtcactttttggaaaagagcagtttatttaacaaatg 40 cctttggcatact[t/c]ggaaatctagcacaggaaaacaaattgaaaccaaaatttattaccatataaaaaagttac/t /ASXL3/additional sex combs like 3 (Drosophila)/ 379/20/rs6083041/2320985/[a/g]/actagatccaacactcaactctttcctggagacactcatccaatttaag actcagcctca[g/a]ttccgccttctggaggaagccttgcttgtgccccttcagactaggccaagccctctgtta/g/T GM6/transglutaminase 6/ 380/8/rs2667975/57067684/[g/a]/ttgcctttgagcaacctcacaggtagactgttaccatcataatggttgg ggaggaagtcc[g/a]gatgcaactcagcttaacaaaagaaggagtaagatgtgcagggccagcataaggagccca/a/L YN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog/ 381/8/rs2667976/57067277/[t/g]/tgaggagattctcttcatcttaggccatgtgattctcttcattataatg tcaggcccagg[g/t]gtgaacaaagacaagaaaaccccaactttctaaaccacctgccgacaccaaagaactaat/g/L 50 (64) JP 2010-88432 A 2010.4.22 YN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog/ 382/8/rs16920176/57061690/[c/t]/tttaaatatgggtatttggtgaagctgtcattttgaaaatcatctctc cctaaggcattg[t/c]gggtccttgcatgctgacagattgactagattttgagcagtcacagaaatctccaccagc/t/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog/ 383/8/rs7813271/57025705/[g/a]/aaactcaacaccttagaaacagaagagtgagtcctcatgtgttgtcatc ttggtggcttt[a/g]tttgccacattggatttcttgttaatattcttcacctttttcttgccgtggaacataata/a/L YN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog/ 384/8/rs7829816/57011940/[g/a]/aattttgaatgttcccaacacaaagaaataatacattaaaaataataaa agcaacaaaaa[a/g]agaaaaagtacagctttgaagccagaccaagttccggttgtacctgagacctttgattac/a/L YN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog/ 10 385/5/rs1549924/107244108/[t/c]/caaagggccagtaagggggtatgtgggaatttgcatctccccatacat cagatgccactc[c/t]cagcacatgataagaagtggttccagaggtcctggtggaaggcctgtagaaccagccagg/c/ FBXL17/F-box and leucine-rich repeat protein 17/ 386/5/rs400155/22587514/[c/t]/tagcaaacctgtcattctagatgcaatttctttatcagtgttcatgttta tcataaaaaa[c/t]atgtgatattcttgtgagggacacagatagttatctaaaggttaaatgcctatggaaaaa/c/CD H12/"cadherin 12, type 2 (N-cadherin 2)"/ 387/13/rs9576827/38978381/[a/g]/ttcagctctggcttctgtggacgtaatattctgtgatcaacagtgcgg ttaatagatgtg[a/g]ttaggaaaacaagaagaggctaccataaaaatgtatgtgaaagagcacctgagggtcccg/g/ LHFP/lipoma HMGIC fusion partner/ 388/14/rs2287015/75115115/[t/c]/aggagactgtggcgatggtgaatgaaggtcccaaccaggaagagagcg 20 atgacacccctg[c/t]gccggagtccgcactccaagcggaccccagcgtctcggtccatcccagcgtctcggtcca/t/ FLVCR2/feline leukemia virus subgroup C cellular receptor family/ 389/13/rs1570976/46027608/[t/c]/cagcatccacttcacatggcgaggtcttagctaaaagatgtgatccct aaaagcactggt[c/t]ttctcaaagaaatgccaacacagcagacacatcaagttcacctaactttgtaaataatcc/t/ LRCH1/leucine-rich repeats and calponin homology (CH) domain containing 1/ 390/3/rs6792725/24495287/[g/a]/ttttccggatttggaaacatctccccctaccccatgagggcgaagatca tcatgatgaaa[a/g]agcagctataactgatgaaaagcttagggggtggggagagattaagaggtagaactaaag/g/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)"/ 391/9/rs4237192/100336965/[g/a]/tggaagacagtttggcgttttcttacaacatgaaacatacccttacca 30 tatgatccagca[a/g]tggagcttcttggtatttacccaaagagctgaaatctgatgtccacaaaaaatcctgcgc/a/ GABBR2/"gamma-aminobutyric acid (GABA) B receptor, 2"/ 392/8/rs11786580/59568494/[t/c]/ttaatgcagcttcagttcaacatttacaagaacctatttttatccata tactatctgatg[c/t]tgcgtggcgatcaccgctgcccggtaaaggcataaagggacaaaaagaaccaacctgaaa/c/ CYP7A1/"cytochrome P450, family 7, subfamily A, polypeptide 1"/ 393/10/rs7904732/68881735/[g/a]/atccaaacaggttaagtaatcccatacacaatgtacaatgatccgtgt tgtgataactac[a/g]tgcaaacacatagttagagttccgaaggaaataaggaaggaagaataggaagagggagaa/a/ CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 394/15/rs7183943/53662358/[g/a]/aaatcctttccttcagactttctctcacaggctcttccccaaccccca atttgtgactgc[a/g]taaattatgctccttctccaatcttaatccaaatcctctatattcatcccatcgagacag/g/ 40 PYGO1/pygopus homolog 1 (Drosophila)/ 395/9/rs7870419/87474994/[a/g]/cagttacataatgttaaacacagagtatcaagaaaagatacacaaatag gaagatgaggt[a/g]gaaaaagatgagaaattatgaagggccctagaagttgttaattcttttgactatggggaa/g/A GTPBP1/ATP/GTP binding protein 1 396/19/rs8103733/38296371/[t/c]/tcttgtccttatcataataaggaaaatctcatgggacctaaaatcagt cacccagattct[c/t]gaactgctttgagaagtgaaagcatcttaggagactttttagtcatgcagaagaggtgga/t/ GPATCH1/G patch domain containing 1/ 397/7/rs12531723/104113487/[g/t]/tgttgagaccacagataccatggtacacacatagtgttctcagacct gcctagtgaagtt[g/t]taggtgttctcccacttcaagagcagttgttccttcaggctagttgttaaagtgacttcc/g /LHFPL3/lipoma HMGIC fusion partner-like 3/ 50 (65) JP 2010-88432 A 2010.4.22 398/12/rs1012682/14842608/[c/t]/tgttatgtgttgttttaaaaggagataataggaataactgaggtttct tgagtagttgtc[c/t]tgctatacacctacgcaccagtttttttccaccagttttctaatcgtcacaattttttag/c/ WBP11/WW domain binding protein 11/ 399/4/rs6813901/83784174/[a/g]/gccactgaactaaccaatcctggaggtgctttatccctggtgtcttact ttgagatgcaa[g/a]gatgtcctattgttgaagccagttgagtcaagatgttctgtagagtagctaaaagcatct/g/S CD5/stearoyl-CoA desaturase 5/ 400/4/rs6535363/83781593/[g/a]/attctggcagggaagacaatgaacaatataaataagcaaattgtagagc acattagtggt[a/g]aataccaggaagaaaaaaagcagagaaggagaatatgatatattaagggcaggcactgaa/a/S CD5/stearoyl-CoA desaturase 5 401/13/rs2984835/101284444/[c/t]/aataatatcatattcctctagtgatcaagcaatcacctccaagtgag 10 actacaatagaga[c/t]tgaaaaaatgtgaaacactgtagaacttgaactgaaatgtcaaagtgctcctagtagatt/t /FGF14/fibroblast growth factor 14 402/14/rs3794485/26129186/[c/t]/cagtactgaacaagtgacaactaacctcttctctctagtcacttgctc ccactggtctac[t/c]gataaatgttaaaacaaactaacctctttttggaaaagactgcaaagctgaatgcacctg/t/ NOVA1/neuro-oncological ventral antigen 1 403/13/rs686323/76423065/[a/g]/taagctgcaaatccattctccttctcacctctgtctcctgcatgcaact ccacagctgaa[a/g]ggagccaaactccctccactctctcacacctcccagccttggcccttgcttccacttcta/g/I RG1/immunoresponsive 1 homolog (mouse) 404/1/rs6425820/33708934/[t/c]/cctctctctgcacactcgcctcccttcttcctcttagggcagatgatgc tgaagtggaca[c/t]gtccttacctgaccctgcaaagctgcctctccagcttcagatcctgacactctctcaaat/c/Z 20 SCAN20/zinc finger and SCAN domain containing 20 405/2/rs1421/47467374/[g/a]/gattggtaaagccagtttcaagctgcttatattttgagtacaggtttcacta ttacaaat[g/a]tatgatgttaaactaacaaactcatgaccttcaaagatgtcttcgtcccacgcacacaca/g/TACS TD1/tumor-associated calcium signal transducer 1 406/14/rs1242017/23745409/[c/t]/ttaggactttgcaataggatcagcccctcaaccccagagaactggtgg cctgtgggcaaa[c/t]gctatgttttgtgcctttactttttggggactgaaggtgagtgggtggatgggaaagagg/c/ TSSK4/testis-specific serine kinase 4 407/15/rs2163195/52127362/[a/c]/tagtgttaattatatttcagttttttgcccattatttcatccctgaat cttcagcctgaa[c/a]aaatatgaatgctgataataaaacattgaactatttaaaaatgtatgttattattaattt/c/ UNC13C/unc-13 homolog C (C. elegans) 30 408/8/rs7846586/74950288/[c/t]/ttaaaatacatactctccaataagaaattcaaagtctacccttacttgt tttactcatta[c/t]caagtaatgaaatcccatgttacatttgtataatatggcattttaaaaaaaatacagttc/t/U BE2W/ubiquitin-conjugating enzyme E2W (putative) 409/9/rs7030075/569035/[c/a]/atgtctgcagctgaaaataggaaaaattgactatatgcatgtttgaacaca tagacataa[a/c]aaatgccagctgaagcagagtattccgcatgcaagccaagaaaaatcgggttcagtgagg/a/KAN K1/KN motif and ankyrin repeat domains 1 410/8/rs10086950/10392788/[a/c]/gcactggtgtggcaagtagaagcagagagaggtcactgtcgagctggg gcggtttgtaat[a/c]tttgtgaataatgaccttctgcacttgctttctctccgagtggatgttgctgaatgttct/a/ LOC346702/similar to hCG1643218 411/10/rs7897274/68446763/[t/c]/caaaataggggatttctaattagttcacataaattgtatctactgaat 40 accttctatata[c/t]gagaagaacctagacacttggctaggtgcaggtgtctgtacaaaaattaatgagccaaga/c/ LRRTM3/leucine rich repeat transmembrane neuronal 3 412/15/rs2279378/72383547/[c/t]/catctccaccactccgaagctgtgtgaccttggataaatcactccacc tctctgctcctg[c/t]ctcctcattgttaagtagagggaacactgtcaccctgtccacctcttgagactatgggga/c/ CCDC33/coiled-coil domain containing 33 413/14/rs2274201/30716992/[t/c]/agcactttgtaatcgtttggttgtagttgaacttaacaacaggactag cagagacttagc[c/t]gaacagtgtgtaaaggtaagtattacttattggctcattacttatttttctcagacctct/t/ HECTD1/HECT domain containing 1 414/6/rs9322464/154790322/[t/c]/ttttagtttcatatcaatgtctttcaaaagcaagccacattgtaggct gcaagaagaaag[c/t]attcaaccagctctacttctcacaaattcaaaatgtttgaggggctaaagacaactctac/t/ 50 (66) JP 2010-88432 A 2010.4.22 CNKSR3/CNKSR family member 3 415/5/rs498221/172247401/[a/g]/gcttctgtgagggaaagaaatcacacaagacaggaaccagagccatcac cagctgatgct[a/g]agaccgtgggctcctggcaggactttctgttaacctcatgccttagcattcttaagaaga/g/E RGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 416/9/rs2151003/20793597/[t/c]/ttgacagaacatagggaacatgggcaagagaactctaggggaattgttt caaatctctta[c/t]gatagggctgcttagaggagtgtacaggactctattgaaagaagcaggattcctaagggt/t/K IAA1797/KIAA1797 417/10/rs923907/117055119/[t/c]/agagttgaatacaagagttgaagacttgtggggaatgagacaatgcgc accttctcctgc[c/t]tcaatagtcatgcttgtctctcgacaaacattattgttcaatgaaagaagctagacatga/c/ ATRNL1/attractin-like 1 10 418/13/rs1327651/49995000/[c/t]/cttcatccctgaagtgcaggccagtcctacctccttcacaatgacgtg ctgacatcatgg[c/t]gcaaatttgcaaacattttttgccttattaagaaaattattcaaacctagaaaaatgcaa/t/ LOC730194/hypothetical protein LOC730194 419/1/rs4652903/36415445/[t/c]/gccttggcctcccaaagtgctgggattacatgtgtgagtgtaagccacc ccgcccagcct[c/t]catttttctttttgttcgtttttgtttttgtttttttaagtgttttggttactgaagtac/c/M AP7D1/MAP7 domain containing 1 420/2/rs10496131/66156377/[a/g]/agtcaactgttcctgggtctaaataggagagagaaagggacattgagg aagttatcaaag[g/a]tgctcggttctcaccctaaagtatgtccttctcctgggtcttttcatcaatgaggatggt/g/ FLJ16124/FLJ16124 protein 421/7/rs310584/150527156/[t/c]/ggctccaaacacagtttctcccgatgcaggcatgcccgttgttccgtgt 20 gggtgtgtgtg[c/t]gaggccttgtgtgagcgtggtgttggggaaggagtgggtacaggcgtgtgtgcccgaggc/t/L OC392843/similar to IQ motif containing with AAA domain 422/11/rs2291842/5676243/[c/t]/ggacaatgaggagcagagagagctgcaaaagctggaggaaggtgaggtg aatgtgctgga[t/c]aacctggcagcagctacagaccagctggtccagcagaggcaggatgccagcacgctcatc/t/T RIM22/tripartite motif-containing 22 423/19/rs349036/49031800/[c/t]/gtgaagctgcatgtgttgggaggcgcttcagattagagagaggggagtt aagtggttctt[c/t]ccaggaatttcctaagagatgaagaccagtggtctttggagtcaccaaaggactccacca/c/Z NF283/zinc finger protein 283 424/11/rs906882/24599163/[t/c]/agagggagaacaaagcaccagtatcagattagtagctaccttagcatgg gagcaggctca[c/t]ggaagcttctcatgacatatgtgttaacccatgggagttttaaggggaagagctccaggg/c/L 30 UZP2/leucine zipper protein 2 425/19/rs4315448/34641548/[t/g]/agcctgcataccacccagaggcactcttactctgccttttccaccatc tcaaacagtgaa[t/g]agaaagaaactatgcagccattacactgtagctaagagggaggaccaggaggtctcaggt/t/ LOC284395/hypothetical protein LOC284395 426/6/rs2690110/25436546/[c/t]/tagaaaactcctagccagtcttgacggaccaagccctacactgagcatg tacagagtctt[c/t]ctgttccatgcagtacttgctaacaaaactaatttaaatgccttaccatgactcgatctc/t/L RRC16/leucine rich repeat containing 16 427/16/rs2972284/5008153/[t/c]/tcagtttcctcatctgtaaagtgaggatagcagtgcctacctcaatagg ttgtagtggga[c/t]gaaatgagggagtagctgtaaagctttcagcacagctcccagaacacagaaagcgctcca/c/S EC14L5/SEC14-like 5 (S. cerevisiae) 40 428/20/rs4925207/59900667/[c/t]/tcgcttgctgtcatgtataagttggatcctgtgatgcacttaaagccc gttggtgactca[c/t]agctgtccacagactgtccagacaccttatggagcacccaggcccctctgtcattcctca/c/ CDH4/"cadherin 4, type 1, R-cadherin (retinal)" 429/8/rs3134058/120023289/[g/a]/cggaaattgcacatattttggctcacagatcttaatatttcttccttt gggcttctgtta[a/g]tcatcagatttgagaattagcatcaggtttgaaagccaattcaacagcagggatggccga/g/ TNFRSF11B/"tumor necrosis factor receptor superfamily, member 11b" 430/11/rs2292572/77730512/[t/g]/accttttcatgatgataccaaaggtctaattccctcacttgtctctct attgctagcctc[g/t]cctttgtctcagttactcctctcttcagggatcttcttcatcccaccacttctcaaaatt/t/ GAB2/GRB2-associated binding protein 2 431/10/rs11258541/13789234/[a/g]/cttcccctctctgctggttaactttcgacagctggcagtttccttat 50 (67) JP 2010-88432 A 2010.4.22 caaaacagagacc[g/a]tagtctgtgcctcctccgcctcttgcttgacacacacacacacatacacacacacacgca/a /FRMD4A/FERM domain containing 4A 432/19/rs189445/49023550/[t/c]/cggctggctttactggggcccgactggaaccggcagtgagggtgggggt ggcatcggggg[c/t]gctggaggtggggagggctgggtcacggacagagcgtgtcgtgtccggatcctcaagcct/t/Z NF283/zinc finger protein 283/ 433/10/rs1572430/86189487/[g/a]/tgttttgaaaagaaacttttttgagctaaggaacaaaagagtggagaa tcctttttggat[a/g]tgagattgttaacttctcttgaggcagaaataaattatatgattgaattatccagacatt/a/ KIAA1128/KIAA1128/ 434/12/rs11114846/80315758/[c/t]/atttacaaccactccctatcacttgcattaccgtctgagctctactt tctgtaagatcag[c/t]ggcagcattagattcacaaagtagtgtgaaccctattgtgaactgtccattcgagggatc/t 10 /PPFIA2/"protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), int eracting protein (liprin), alpha 2"/ 435/11/rs231906/2709185/[t/c]/gtgctggctccctttcccaggcctctcccgctgacacacagccggaatgt gccagactca[c/t]caaggcctgaattcccgaggggtctggcatgccgactgtgggacgagggcatttgggcat/c/KC NQ1/"potassium voltage-gated channel, KQT-like subfamily, member 1"/ 436/13/rs1887695/101209736/[t/c]/ggatggagtagagaatgcagtgatgaatccaagagtgatcaggatgg ctaaagatcataa[c/t]gcatcagtgggcaataagcagttagcggaggtggggccagtggtgcagcccatgcagact/t /FGF14/fibroblast growth factor 14/ 437/4/rs7692790/186828441/[c/t]/aaggtttattttgctttaaataaaatatttaagcttaaaataatgtgt gagtgttaataa[c/t]gtgcgtttcaacttttcaaaaaaattctaatgacttaaacattctaggaaaaagctcatt/c/ 20 SORBS2/sorbin and SH3 domain containing 2/ 438/18/rs1470829/29778911/[a/c]/aacatctttgcctcaaaaattagctcaatcaagaaagatatcaatgag tatctaattccc[a/c]tgtagttggactacatttttgagccaggcagtgatcatcggttaatgagactgattttat/c/ NOL4/nucleolar protein 4/ 439/17/rs7503807/76205706/[c/a]/tgggtacagttttgtaccctcctcttttcagttatgtttgagcatgtc ctgtgccattta[a/c]tattctttgagaacatattttttaaacagctctactgagatacaattcacataccccaga/c/ KIAA1303/raptor/ 440/8/rs10503814/27510492/[t/c]/ccccataattctaattaatgtatatcattaagtgaatcacactgactt tactctgaattt[c/t]cttgacagccatgctaaaatacttaccttggacataagctaagctttaagtttgttgttt/c/ CLU/clusterin/ 30 441/10/rs6585987/87655958/[c/t]/aatttaagtcctaatgatagagggttaataaatcaagagaacataaaa atcctaagcatt[t/c]atgccccttgaaataaagcttccaaatatattaagcaataactggtaaaactgaaaggag/t/ GRID1/"glutamate receptor, ionotropic, delta 1"/ 442/7/rs6980283/146381187/[t/g]/attattgtagggataaggctaatgatgaaagtgcacatgatagatact ttcacataattt[g/t]ggtataagccttttttgcaggggttggctaaggtagatagctagtggatcagatactcag/g/ CNTNAP2/contactin associated protein-like 2/ 443/16/rs166980/81445132/[a/g]/ccaagttctaattcttacagcaatgaggggtgctgctttactgctttcc atccccttacc[g/a]aagttactgtgaatgaaattgaagagcggatatcggtggcaagttcaagcatagatactg/g/C DH13/cadherin 13/ 444/9/rs11103509/136793924/[c/t]/actccatcggtcctgctgatggatggagctcggggccagctctcagc 40 tctcactgcagga[c/t]gcaggtgccccaaaccccactgggaggaaaggtggccagagcgtttactgagctcagcgt/c /COL5A1/"collagen, type V, alpha 1"/ 445/1/rs16836320/152984532/[t/c]/tttggttggtgtggctttttctcaccgaggtggtggcatctctgtct ccattagtggttt[c/t]ctgtagaagcttctgagaaactctggaagaggtgggacagctggctggtgtcacacagct/t /KCNN3/potassium intermediate/"small conductance calcium-activated channel, subf amily N, member 3" 446/4/rs2070022/155724398/[t/c]/tggcagacagaagcttctctctgcaaccttgaagactattggtttgag aacttctcttcc[c/t]ataccacccaaaatcataatgccattggaaagcaaaaagttgttttatccatttgatttg/t/ FGA/fibrinogen alpha chain/ 447/18/rs8095324/22385657/[g/a]/cccctcgaccaaaagaaaaaaaaaagttgcttaatttttaaaacccaa 50 (68) JP 2010-88432 A 2010.4.22 taacacaaaatt[a/g]cagtggagttcataaagtagttcaattccaagtttaataaatgatcccttaaaaacatcc/g/ KCTD1/potassium channel tetramerisation domain containing 1/ 448/18/rs9948310/22390252/[c/t]/ggagactgccttggagaggggcagagaagcaggaaacattgtgacctg gcccctctcttc[t/c]gtgacctaagtttgcagagccagggcatcattgctcccaggggaagcctcaccattcttc/c/ KCTD1/potassium channel tetramerisation domain containing 1/ 449/16/rs2019698/86253773/[t/g]/ccctggtggcccctccagagtctgtcccggccatggaccccagtcccc gctgagccatgc[g/t]gagagtttgggagaagtgcatacctgccttgggggcttgactggcaggctgctttcctct/g/ JPH3/junctophilin 3/ 450/18/rs7244139/20043725/[c/t]/ggaaagagcaacgatatatacaataggaatggaagtcaagacacggtg ttgagtgactaa[c/t]gccacattcaaggagcacacgcactgtgattcatttataatgcagttcaagataagacta/c/ 10 OSBPL1A/oxysterol binding protein-like 1A/ 451/3/rs507961/128941399/[a/g]/tctctatacgtgcttcacctagacactggccagcatacagcaagtgctt agcaaaggtgc[a/g]ctgggggctggctgcatgcacacttggaggatggtagaaagcatctccaggaacccccaa/a/M GLL/monoglyceride lipase/ 452/18/rs615916/3673212/[c/t]/ggccatatccaaaactttgaggaagaaaatccattgagtggtatgtttcc tactgagtgc[t/c]cttactgatcagttacagagaaggagctgatggtagatgaaatcaggtgagaaaaggtca/t/DL GAP1/"discs, large (Drosophila) homolog-associated protein 1"/ 453/17/rs4889875/76266095/[t/c]/tttgctgggcagttttctcttcctcaacttgttaaattctattcatgc atcgagtcttgc[c/t]gttgatgtcattttctttggaaactgttcctaaatccttaatcctttctaccttacaaaa/c/ KIAA1303/raptor/ 20 454/10/rs2394375/68825642/[g/a]/tatattggaaagagctctgaaatggaaaccaagacttgtggctttgcc attaaactaatt[a/g]ttgccttgaggtcaccctgaaatcctctactttcttgtttgtaaagtagggaaataattc/a/ CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 455/4/rs907432/164752692/[g/t]/attggatataaaaggagaaaaggtgggtatgaaaagaataatgcagatg taaacatgggt[g/t]tgaaagctgttaccaagtacaattagatatccccttcctttaaactgaataatgatttat/t/M ARCH1/membrane-associated ring finger (C3HC4) 1/ 456/1/rs1884994/172216905/[c/t]/atgtaacaaatttagcatcaacagcaagattaaatgaatataccattt gcctgcaaaata[c/t]tttctccttaacttgttgaggtaggtatattgctatcatcccattctgagtcaagttgga/t/ RC3H1/ring finger and CCCH-type zinc finger domains 1/ 30 457/20/rs1535882/1548524/[c/t]/gccatggctcagtgggcaggaaaaaagattttaaccgaaggcagtgctc acctgtgagtc[c/t]ccccagcagtagcgtcatcagcaggaaaggactaggaaggtggggccaggaggctggcac/t/S IRPB1/signal-regulatory protein beta 1/ 458/9/rs4742223/665600/[c/t]/gattgaaatataagtcttattatggtaatctcaggtaacttttaaatagaa atatcaatg[c/t]aaaatgaatatattgcccaatgtggaccccggtgtttcagaactatgtgccatgctctat/c/KAN K1/KN motif and ankyrin repeat domains 1/ 459/5/rs980040/22577100/[t/c]/cctcctgccatgagcagacaatggtgtcagatacttgagtgacacttccc ctgtcaaagc[t/c]ccataaaatcccacctggctatgcagctgctgcagggctttggcagttcgccagaaactc/t/CD H12/"cadherin 12, type 2 (N-cadherin 2)"/ 460/15/rs2448928/84920344/[g/a]/aacattggatgactcagaaggaagaagataattaatatttacatggac 40 tttagcatttct[g/a]catgctaactccatcatttattgactgcactttgggtaaattatttatgcttttaaaatt/g/ AGBL1/ATP/GTP binding protein-like 1 461/1/rs10800120/163871934/[a/g]/cttttaagtgtaatttaaatctggctgtcatgaaggtttggcgctca aacagattttagc[a/g]tctgtttaatgtagaagtggactggaactagcattctgaaaatgtagtctgaacccaaag/g /MGST3/microsomal glutathione S-transferase 3/ 462/10/rs12264955/126244685/[t/c]/tgtgggcagttgccatgccactccggcggcagcaagagcagggaca ggtgtggcagagcc[c/t]ggtggttccagcccagcctggcctcccagcatcaccttctccagttacttgaagtgggcc/ c/LHPP/phospholysine phosphohistidine inorganic pyrophosphate phosphatase/ 463/14/rs4903329/75113654/[g/a]/attcaatttgtttagcactgtacaacaaatgttagctttttgctagga tagccagcattc[g/a]cggaatgcttactatgtggcaggaattttctaagtgcattcgtgtattaattcattcaag/g/ 50 (69) JP 2010-88432 A 2010.4.22 FLVCR2/feline leukemia virus subgroup C cellular receptor family/ 464/19/rs4926285/13392611/[c/a]/ctagaaagccaatatagggagagaaagatgaggtgacatgcctttgcc cctgatttaata[c/a]ttcagttaattctggaaaagaaccccttatcagataggtcctgtttgacaatttgattca/c/ CACNA1A/"calcium channel, voltage-dependent, P"/"Q type, alpha 1A subunit" 465/6/rs9397717/154790779/[a/g]/taggggtaaaaactgggcaaggtatatgaacaagagcaataaaggaca atttaaataata[a/g]attgacaacagctggtgacaagcagtactctatcaacagaaataaacaaagcaggtaccc/a/ CNKSR3/CNKSR family member 3/ 466/1/rs6697935/152978982/[a/c]/caagggacacagcctgccaaccaccacatgagtagcttagaagcaggt gttctttaagtc[a/c]agccttgaggtgagaccacagccctggctgacagcctgacaatctcatgagagaacttga/a/ KCNN3/potassium intermediate/"small conductance calcium-activated channel, subfa 10 mily N, member 3" 467/1/rs2809295/214619647/[t/c]/atgacagcaagttgtcaacagatttcccaaggatttctctgaggaact agagacttacaa[c/t]ggggagaaagtgtcattccatctgaatccaaccattacatcaattgacctgaaagctaga/t/ USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 468/18/rs12150701/58032634/[t/c]/cctatcaaaaggccagtaattgggaaaagataattgtctttcatctg ccattgaattaca[c/t]gtaaacctcattaactcctcatggtttggagtcttgtgcctgcagctctcccaggctact/t /KIAA1468/KIAA1468/ 469/18/rs3752093/58076918/[t/c]/tctgtctctgttctctaacattgttccaagatggcttaggacagacct tttaagtttcta[c/t]aaactatataaacaaaagaagaacttaccctgagaagtttttcaatcttgttcagtagtg/t/ KIAA1468/KIAA1468/ 20 470/14/rs765034/97285394/[g/a]/gttgaaatcagactccaagggatgaaatagatatttattggaagaaaca tcatttattga[a/g]cacctattatatgcatcatgttaaggtcccatgttagaggaaagttaaattgcaggtttt/a/L OC100132612/hypothetical protein LOC100132612/ 471/20/rs6115830/325226/[t/c]/gctcacagccacaggcatcctcctgcacccctggctgcgacaggacccga tgcccttagc[c/t]ccaacccgatcccatctctgggaggctgcccaggtggtccctgatggactggggctggac/c/TR IB3/tribbles homolog 3 (Drosophila)/ 472/2/rs2612699/111302685/[a/g]/tgcttcagtttcccaggtctaacttggggattacaacggctccttact cacaggcttgtt[a/g]agaaggctgatgagatgacgtacgcaaagtgctcagcacaaggatagtacaacgctcaca/g/ ACOXL/acyl-Coenzyme A oxidase-like/ 473/11/rs7111334/75315215/[t/c]/aacatgggaggaaaactgactttaaacagtttatggggagaacatctg 30 gagatttaaact[c/t]atgaaaaattcagtgtaagccaagaaattgactcagcagcattaaaaaaggagctaagat/c/ UVRAG/UV radiation resistance associated gene/ 474/15/rs4580136/98893021/[t/g]/tattttatgcatatagacttagtttctccacttaaattttgagtacaa ggattgtgtaaa[g/t]tttccaagttgcaggcattactgttctctgaacatagtgttcagtcattaactcattcag/g/ LASS3/"LAG1 homolog, ceramide synthase 3"/ 475/7/rs697404/90516805/[a/g]/ttacaggtatgaaccactgtgcctgaccacaatttttttaaagaccaatt tctgttatag[a/g]tgtatgtacaaattcatatatgtgtatctgtgtaagaaaaaccagtttgggttttcaaat/g/PF TK1/PFTAIRE protein kinase 1/ 476/17/rs901065/76214250/[t/g]/tgagtatgcctccctcacgcgctgccacaaaggccgtctggccggctct ggcctgggcgg[g/t]gctcgccaagcctgtggtctggtccaggggcccgtctccagctgtgcaaatctgaggggt/t/K 40 IAA1303/raptor/ 477/9/rs2361093/596676/[a/g]/atatatttatatatttatatatattacatatatatatatgtttagaaaata aaagatgca[a/g]tatgtcagtgctttcttatgacagttgcagctacaaaggaagattaaagctttttaaaaa/g/KAN K1/KN motif and ankyrin repeat domains 1/ 478/1/rs795047/36410295/[c/t]/gtccacatactgtgattaagagcatgggatttggggtggcaggaggcttc tgggtctgaa[c/t]gtcagctactctactagctgtgtggcttaagcaaatgatttcatctctctgagcctctgt/t/MA P7D1/MAP7 domain containing 1/ 479/22/rs5993883/18317638/[g/t]/gtctattatttaacttcacttagtatgactctgaggttgaaagttact gaaaacatcttg[t/g]aagcttttttaggccaatatattatcaaacgcaattaacaaaacacaactcactagttta/g/ COMT/catechol-O-methyltransferase/ 50 (70) JP 2010-88432 A 2010.4.22 480/13/rs7320400/71314340/[t/c]/atcttcctctataaaatggagataagactgctatgaggattaagtgag ataagaaatgca[t/c]tccaattagtgcttggcataaggtaagtgaacaaaaaataatactgatagcagaattgga/c/ DACH1/dachshund homolog 1 (Drosophila)/ 481/11/rs7930593/492013/[t/c]/ccaagtggtcaggtacgcttgctctcggggtggccttggggtgctggtgg ggcaggctgg[c/t]gggtggcggctccctctgaagggtgcattgctctggaacgccttgtttgtggacatgaag/t/RN H1/ribonuclease/angiogenin inhibitor 1 482/11/rs7935013/457339/[c/t]/caccagcaatgggtgagagttcctggaagcgttggtactgtcggttttta aggttttagc[t/c]gctccgtcgggtatgcagtggcgtctccctgtttccagttcctgaaggacaaatgatgct/c/PT DSS2/phosphatidylserine synthase 2/ 483/1/rs9439799/77548441/[c/t]/tatagtgtgaggtagcaatataactttattgcatgttttgaatggaaat 10 gaaaaatgtat[t/c]cagtggtccaaagaacgtttgttgacttgcgcatcttttccttcattgaaatgacttatt/c/A K5/adenylate kinase 5/ 484/3/rs4353759/24487960/[c/a]/gcttatcagtgcatactaaattaataattgatagtcttttagaatttgg gcctccaacat[c/a]tatctaatgcaatgttgtggttttaaatcctttttcaggccttcttgatttggacccacc/c/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)"/ 485/6/rs721101/155674536/[c/t]/ttgaaaccaaccgactcctaagaacagactggataagaatgcagcactt ttctatagtta[c/t]tgaacattgaatatctgaataagcaatactagtttcacattcagaatcttcagtattgct/t/T FB1M/"transcription factor B1, mitochondrial"/ 486/5/rs1463747/152893697/[a/c]/ctacttggtcagtctctacactctggagtttgacagatttcaattcca 20 ttcttagctctg[a/c]acttttttcacataggtgaccatgggtgagttattctatgctaaacctcagataagcttc/c/ GRIA1/"glutamate receptor, ionotropic, AMPA 1"/ 487/5/rs394857/83466363/[a/g]/atatgatctggcattctagcatttcctgtattctccgtgtgctgacaaag agatcagaaa[a/g]agtcacctagagagttccctaaaatattttcctattggggtgtttgcttttattttatta/a/ED IL3/EGF-like repeats and discoidin I-like domains 3/ 488/7/rs3934669/104139197/[c/t]/taggcttgattcaagatggagatgatgtccaaggcagggtggtggcca agcagtggattg[c/t]gtcctgcagtaagatagccccaagtcatggcctttctgaacatcattagccttggtcaag/c/ LHFPL3/lipoma HMGIC fusion partner-like 3/ 489/6/rs9294882/71706893/[a/c]/ccaacaggtgctggtcagaagaatattcctaaccttcccagcccaggaa atgaccttaaa[a/c]tactgcttctaatcatgtgctcaaaaaaaaaatctatttcgtgccctctcctttgtaaca/c/B 30 3GAT2/"beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)"/ 490/2/rs2118891/212387888/[g/a]/gaaatcagaggtgtaggcacagcacctgtggtgtttccatcagtttgt aatggtgtattc[a/g]tgtgtataaatgtggcatatgtaattaaggtcctgtgccatagcaactgtaagcacaggc/g/ ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)/ 491/9/rs4740817/551143/[t/c]/agggtaagccagggaaataaatggactagaaactatgccctaccaggaata gttgaaagg[c/t]tatcggggtggaaaggagagcaaagttaattctcaacttcaggggggcaggattggaatt/c/KAN K1/KN motif and ankyrin repeat domains 1/ 492/20/rs2209313/1547142/[t/c]/ttggaaataggggataatagttgcagctttcacacagggatgttgtgag gattagtggag[c/t]taaaacaggcaaaatgctaataactgtgtctacatggtaggaagagctcaattgttaaac/c/S IRPB1/signal-regulatory protein beta 1/ 40 493/19/rs2270941/54130175/[c/t]/agggggcaccgctccaggggcggcggccagcacccccatcgccctcgc cactcacccacg[c/t]tcgggtccttggccagctcctcataggagccgtaggccttggggatgtcgtgtttctgtg/t/ DHDH/dihydrodiol dehydrogenase (dimeric)/ 494/3/rs6770096/32971513/[t/c]/taataacatatctcaggcaaagtatattccattgagccagatgtatgaa gaaacaattag[c/t]gaagtgatgaaaccagatctcaattatttattgtaaaggattatctgttaattgaaacca/c/C CR4/chemokine (C-C motif) receptor 4/ 495/11/rs10501823/94590558/[a/g]/catttcaaaggaagaattctgactgaatagggcttgaatcttgcaca ctgcactagttat[g/a]tcatggcttgatctgggtatcattagatcccaaccatggaacgcatcatatactgatgct/g /SESN3/sestrin 3 496/11/rs10831318/94585583/[t/c]/atatgctatagataggcacagtaccttcattcatttccagattgtat 50 (71) JP 2010-88432 A 2010.4.22 tgatctatgtcta[c/t]gcatctgagccctcattagcctcctacacacacattattattcccttggtgatttaccca/c /SESN3/sestrin 3 497/11/rs629508/94562047/[c/t]/catattgaataatgacctcaccctgtaggcctttgatggaagcgccttc agaaatacaag[c/t]gctcttagtcaatcacgacaactctatttctcgtctaagctctagttttaaaaggcattt/t/S ESN3/sestrin 3 498/1/rs1878076/163883944/[a/g]/ttcagtcatttttatttattttcaaagaggtgttcagaattcacactc tgtttttctttt[a/g]ataactactgtggcttcctcctcatgctgactttctacacttgggaagagaatgtgggca/g/ MGST3/microsomal glutathione S-transferase 3 499/17/rs7218204/15357533/[g/t]/caactggaattgataagtatagaggaagctccagcctgagatggggga ttgaacgtcatg[g/t]ttgaagggctgtccagtcctagcgtcgatagcaagggaccaagatttataactttaaatc/t/ 10 FAM18B2/"family with sequence similarity 18, member B2" 500/9/rs3935382/93586385/[t/c]/aaatcccacacccaatccatcacgaaatgctgtttgctctatctg[c/t ]agaatgtatcaggacctgccctgctaacatgctgtgggcgactgcagcaccccctggccc/c/ROR2/receptor ty rosine kinase-like orphan receptor 2 501/7/rs10260766/131868326/[t/c]/taggttgtgatgaggaataagtagagcaatcagtggaactggttgcc accaccacaaatc[c/t]ctcctaacttccaaaccgaagggatttctgtccttcctttaatttccagaataatagaac/c /PLXNA4/plexin A4 502/6/rs9394865/42181936/[t/c]/gggcttagcctccttctctgctgctgaggagagccgggcctccagctca ttccggatctg[c/t]cgcacactgggagttggagagtcttggggaatgtagtccacagagggcagggtcaggctg/t/L OC100128918/hypothetical protein LOC100128918 20 503/4/rs11929713/110652299/[g/a]/acaaagacaaaggtatttgtatatggtatgtttctctctcactgtta tttctaaagttaa[a/g]ctgataagatctcacttacattattttcttggccaatgtttgttatgactttattttagt/a /SEC24B/"SEC24 related gene family, member B (S. cerevisiae)" 504/9/rs10448161/20765272/[c/t]/agccatttttagcctgattagaataatcataacttaaggtcctttcca tttcaagcaaaa[c/t]agatgtaccctgaccagcaaaattaggcaaaaatgatgctcactgggaggagattgggta/c/ KIAA1797/KIAA1797 505/13/rs798987/31685876/[g/a]/ataacattcttgatcatttattgttttgtctgagtttcctgtctgaatt ttatttgaggt[a/g]gaaagatgatagatctccatgtattaccatctcattacaaaggcctgtttagggccagag/a/F RY/furry homolog (Drosophila) 506/4/rs7694402/110729529/[a/g]/aattggatataaagaatgattgataaaaaggaagtgtaatagaatttt 30 tcatacaacctg[g/a]taaaccatttttgaaattcattggtaaaaggatagaacagtctagaaaattctgaaaaaa/g/ CCDC109B/coiled-coil domain containing 109B 507/17/rs4889863/76165063/[g/a]/ccacctactttgactgaaagacttcagaattcttttctcatgacggtc tactgatgccac[g/a]ttcacttcgttagtctgaaaatatcttttttgtttgtgtgtttttgtttttttgagacag/a/ KIAA1303/raptor 508/13/rs916732/31645122/[t/c]/tagattagaatctaacaaacaagtaagcaaggagaaatagaaagtaaat gtttgaaaatt[c/t]gattcaatagtatccaaaagtctatggagaatttaaataacaactttggccactttgatt/c/F RY/furry homolog (Drosophila) 509/9/rs3128591/136741940/[g/a]/actcagcgtggtggcaggtgcgccgctgtgtgctggcaggctctcctg cccgcgcgagac[a/g]gtggctgttgtgatgatgatgatggtagtcatagtgattgtgcagtattttcatagcatc/a/ 40 COL5A1/"collagen, type V, alpha 1" 510/9/rs4841926/136741106/[c/t]/ggcagctgcctggctggctggagccagtgtgcagtgtggcattggggt gcagtttggtat[c/t]ggggtgcattctcatttgcagttctggtctagggaggcctgagtggtgagcgagtgaggc/t/ COL5A1/"collagen, type V, alpha 1" 511/13/rs11617458/97665446/[g/a]/attcctagctactatttagcagctatccaggaactccctgcccaaga agtagtaatagaa[a/g]tgtgtttttatcttttaaaatgatttttcttcataatttctgatggcttatgctttgcat/a /FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-deriv ed)"/ 512/9/rs2281872/37730637/[a/g]/ctcggaactgtcactcaggtagctggccggggagacactggaacacagg ctgtagtagtc[a/g]gcgtggctgccttcatacagcctggggtccagcctgactgtgctcagttctggtgcccag/a/F 50 (72) JP 2010-88432 A 2010.4.22 RMPD1/FERM and PDZ domain containing 1/ 513/1/rs2602948/77530012/[a/g]/ttggacactgaccatctgccaagcacagttctagatcccagggatacag agctccagacc[g/a]taggtaaggcccctgctctcatgaaacttataatccaataggagaagacaaacaatgaat/a/A K5/adenylate kinase 5/ 514/1/rs2815319/77547654/[g/a]/aattgatcatgattaacaatatattcaactatctggtcccaactaattt tccagttttat[a/g]tacctgtctacacgttcgacatgctgtaccacttcctgtttttcacagtgatctgctcct/g/A K5/adenylate kinase 5/ 515/18/rs7243826/22407464/[a/c]/cgtgatgctgccctacttataaagagacaaaaagggcaagttgtttat tttgaattaata[c/a]gaacaataaaatgtttatgtttgggcacaactatgccggaagacgtgataaggtggtgag/a/ KCTD1/potassium channel tetramerisation domain containing 1/ 10 516/7/rs2385542/104626001/[g/a]/tttaccaggcaccccctactgcctctgaaaaccccacatgaaacacaa atcttcccacaa[a/g]aggaggtttggctgtgacacaggttttttttgctcaaactcatgaaacaagcatgtatga/a/ SRPK2/SFRS protein kinase 2/ 517/7/rs1859786/104592740/[t/c]/ctactccaggcacacaaagggctatctcagaggatccaacacccacat aaagaaaaagta[c/t]tcatgacactgaaggcatcatctcttctcttcatttttgctttcttctctgagctacagg/c/ SRPK2/SFRS protein kinase 2/ 518/7/rs2237606/104581077/[t/g]/tccttgaacctcaaattcatcttcaaaataaggggcttggttaaaatg gtctcaaagctt[g/t]ctttctgtacatcaacatttgtgtcagataccatctattactggtcttcgcaacacaaat/g/ SRPK2/SFRS protein kinase 2/ 519/7/rs2240453/104483424/[t/c]/ttaaatgtgtcatgttgttgttatctctgactgcatgtgtgctttctg 20 tctggaatactt[t/c]ctccatctctttgccttctctatttcatggacttgttaaattgccattctttaaaacttg/c/ MLL5/myeloid/"lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophil a)" 520/1/rs12565526/77600909/[a/g]/attatgcaaatcacaatcactttttaaaagcaccccaacagaaaactt tctctaagcagg[a/g]catgaagcatgaatgcacagaagaaatagaaataatcatcaaacaaattataaaaacttg/a/ AK5/adenylate kinase 5/ 521/5/rs6869495/59686293/[g/a]/accacaattggaggttggggcattctgaaccatttttagtctgggatgt tgcccagtact[a/g]ggacgtttttctggctcaaataaatttttttcaatgtaattggtctctgggttagttttc/g/L OC653198/similar to phosphodiesterase 4D/ 522/9/rs1948308/86806077/[t/c]/agatcgcttgcccatcatctgaaaaggcaaagacatgtgagtctttcaa 30 gaataagtggg[c/t]actgtggaaaatgtctacttttagcctttttgtctgtactctggctgcccaagggtgacc/c/N TRK2/"neurotrophic tyrosine kinase, receptor, type 2"/ 523/2/rs1561609/164207761/[t/c]/ggccctggcaatttcgtatgaattttagaatcagtgtatcaatttcta caaataagtaat[c/t]tgggattctgatagggattgcactgaatctacacattaatttgaagattattgccatctt/c/ FIGN/fidgetin/ 524/15/rs2289181/46877467/[a/g]/atacaagtgaaagtgacttcaggtgcttactgtccgtctgtgccatcc tcgctgcagtcc[a/g]aatactggagctctggagaggagaggtcgtcatccagcatgtcatggggaaggtctgtga/g/ CEP152/centrosomal protein 152kDa/ 525/9/rs12339991/125550906/[a/g]/gctggcttgcagggaggtccaagaaaaattgttgacactcaaactca atcaaaaagcacc[g/a]aggagcctctcctgtagaatgctttttcatctcccaaaaagggtccctcatgtcgaattc/g 40 /DENND1A/DENN/MADD domain containing 1A 526/1/rs1721165/77538382/[a/g]/gggttatgcttttcggagggaatcctctcttccctccctctcccaccta ctgcaagtcac[g/a]tgagtaggaatttcaggattctgatacaccaccttagctttctgagtctgaatctggtcc/g/A K5/adenylate kinase 5/ 527/1/rs12076479/77529866/[g/a]/taaagctaaaccctttaccatggtaaaggattcagggacctccatatt gaaccacgctct[a/g]cccacccattttatcttctgagttttctctatgggaaactatttcagtaagatgttcttt/a/ AK5/adenylate kinase 5/ 528/8/rs7006025/59517607/[g/a]/acaattatttactgagcaggaaataaaaagaagcaagtaaaacagaaat gaaaataatct[a/g]ttgtcttccatagatggcagtctaattacacacagaatgttacatagatgggaactaaat/a/L OC137886/hypothetical protein LOC137886/ 50 (73) JP 2010-88432 A 2010.4.22 529/14/rs2300525/80567146/[c/t]/gacctctctgtaaaagctgcggtataatgggaactagcatgctctgac tggttgcctcaa[t/c]taataaaacagtcaggaaatctcgagggtttccttccacagatttgagtatcccttgatg/c/ TSHR/thyroid stimulating hormone receptor/ 530/1/rs2075972/9329566/[g/a]/cccgaagagggacattatttctacagtgatctatcccaagacttccgatt atactgtttc[a/g]aaattacagattttaattagccccgtaaaaatggggcggctgtctctctctactgaccca/g/SP SB1/splA/ryanodine receptor domain and SOCS box containing 1 531/17/rs758142/53095785/[c/t]/atagtcagaaataacttcccgaaagaggggcgagcggggctggggtgcc tttcccggcta[c/t]acaagcctctgccacaggcacgcaggcatcaaatgtttaccacagacctgggcagaccat/c/M SI2/musashi homolog 2 (Drosophila)/ 532/20/rs379863/42694108/[c/t]/ccgtgcccagcaccagcccgtcccctagaacaaattattttgctttcta 10 tttctcctctt[c/t]gattcttcttctccagcctccctcctcaacaaccatcaagaaggaacttctcaacacaga/t/A DA/adenosine deaminase/ 533/13/rs1536002/47324955/[a/g]/tcagcctgaatggggaagtagagcccttctttagggtgaagtggtccc tataaaggagtt[a/g]gagaatgtgggtaagaagtgcccggaggaaatgaggcagcacatcagaggtggatcttga/g/ LOC730174/similar to Nucleosome assembly protein 1-like 1 (NAP-1-related protein ) (hNRP)/ 534/10/rs2394319/68464762/[a/g]/ctgcctgaaatatgcccacctatgtctatactaggaactcttggaagg ccccgttcagaa[a/g]tcacttatttcaagaagcccttattgaggtcaccagttagaagtgctcactgtattttat/g/ LRRTM3/leucine rich repeat transmembrane neuronal 3/ 535/6/rs12200614/96651135/[c/a]/tggagttcttacacaggtttataagaatttacctaatctgtcccatca 20 ctcccttaatct[a/c]tctaatcttgtctacaagtttcacttctttaagtccactctcactgctctggtcccctca/a/ FUT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)"/ 536/6/rs17056048/96639411/[a/c]/gcacactatggtcttcagtcccaacttctcattactgattcccatttg tatgtcttcact[c/a]tccacagacatttactctaatgtttgatatacatccctgtttatatatataacccttgca/c/ FUT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)"/ 537/4/rs10518539/130046715/[g/t]/ttttagcctatgcatgctttaattaattccacagaatcagttgccta gtccatccagtaa[t/g]aacatttctaatatcttacatcttgccttttcaaagtttttgctaagtacttgctctcat/g /SCLT1/sodium channel and clathrin linker 1/ 538/4/rs6835359/130080244/[t/c]/caagtagataactgaattgctggaaacgactccatttcttaattttag atggtaatgagg[c/t]ggaatttagaccatgaagaaatggagagccctggcaaaaggagtggttagaaaaggagaa/t/ 30 SCLT1/sodium channel and clathrin linker 1/ 539/17/rs708692/34144475/[c/t]/agggataaactgcatttgtaaaaggcactgttcttagcaatttctggac attcaacaacg[c/t]ggggggcggccactggtcagaggcaggacagcagccaagatggggagagaaacggggaga/c/P CGF2/polycomb group ring finger 2/ 540/12/rs885389/130187715/[g/a]/tgtgtgccctggggcctgctgctgagcagctcttctctccccgcctag ttgctaagcgat[a/g]tgcaagcatcctctctccctggagaagtggcgactgcatcttagggagagtgagatgtag/a/ GPR133/G protein-coupled receptor 133/ 541/6/rs3024443/6126525/[g/a]/gcaattggtttggtgctggcgattccagcagtgagcaggactcagttcct gtcctggtcc[a/g]agtgacaggattattgtgcagaggggtctttggaaacaataagtaggggcatttagtcca/a/F1 3A1/"coagulation factor XIII, A1 polypeptide"/ 40 542/5/rs793228/172296918/[a/g]/aagaaaaagttaacaaccaaaaaagcagacaaggccaaggaccagctct tcacagaggag[g/a]tgatattggcagtgaaaagatgcccaagttcactagaaattggagggatgggatttaaaa/g/E RGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1/ 543/2/rs3814026/112358137/[c/t]/ggtccttcacagtgactcttgggccgcagcagcttctcattccctctc cctcccctattc[c/t]ggaggaagaacgggcaacagcagcgggctcgagtgctaatggcaggaaggcgtgcgagac/c/ ANAPC1/anaphase promoting complex subunit 1 544/2/rs2587708/119909307/[g/a]/cctggggttgaaattagcggtagctcctgtgtctggggcatgtgagca gatactcttgct[g/a]ggctctttgaccacaggagtctcccagaagcagggctttattttatgtctcacacagaga/g/ TMEM37/transmembrane protein 37 545/10/rs1250550/80730323/[t/g]/tcaggaccccatccctgaccccaatgattcccccagcctgagttctcc 50 (74) JP 2010-88432 A 2010.4.22 tctcccattctg[g/t]atactccctctacacccaaactgcccccaagacccccgcacaccaatcattcccatcaca/t/ ZMIZ1/"zinc finger, MIZ-type containing 1" 546/11/rs1262181/95532144/[g/a]/tctccacagcagtaagttcaatgcctttaaatcatcagccctaaatta cctttccaggcg[g/a]atttgttgtcagtcccttaccccatctcctgtgaagccaattcagttactaaccgtgcct/a/ MAML2/mastermind-like 2 (Drosophila) 547/7/rs6968634/131518382/[g/a]/ccaatcaaaggagcatcttcgagaagaatcctgctatctaaaacaggc tttagcaagtta[a/g]ttagctagaagttgatgagtaaagaatccttgacacacacacccacattcatttccaccc/a/ PLXNA4/plexin A4 548/5/rs40512/59841224/[t/c]/tcctaggattttttctctcatttcatctttctttcccttcatccacctttg acttcacct[c/t]ctgcttcttggctacacttctggccttgcatgcccacagcttctgcatttttctctccca/t/PAR 10 T1/prostate androgen-regulated transcript 1 549/18/rs6506520/7617956/[a/g]/gattccaaataagaggccctgcacaaatggagattctgatgtatgcagc tctctacctgt[a/g]tctatttgaaaacaaaaagccaccttattttgtctaaaataatttgaagaatttttagat/a/P TPRM/"protein tyrosine phosphatase, receptor type, M" 550/2/rs6875/97739412/[c/t]/agcagattacagaaatgtaagtcaacttaagaacagtgaatgaatgtaaaaa cattcagt[c/t]gagaccatatgcattttctgtgctgtttgtacttgaggtatgtaacatttgtatacctga/t/TMEM 131/transmembrane protein 131 551/10/rs1411896/24783826/[c/t]/gcaacaaatttctgaagcattaagatctgaaccctgcagatatctggt gagcgagttgtg[c/t]tgcagtggagcagatttttttttttttccttgcagttacacagctgctagaaaacatatt/t/ KIAA1217/KIAA1217 20 552/13/rs340223/59364890/[a/c]/tagaccattttaatttaatctggttattcatatggcagggtttaaatct agcatcttact[c/a]tttattttctatttatctcatctattctttgctactctttttctaccttcttttggattg/c/D IAPH3/diaphanous homolog 3 (Drosophila) 553/3/rs2134655/115340891/[a/g]/tttagctaaattggagacacaaatctgacaccgactttggaatctgct aattttggctgc[a/g]ctttgaaggtaggaaatccaatctcaagaaaacattgatagttgcctctagagcctgcct/g/ DRD3/dopamine receptor D3 554/1/rs2198511/77606955/[c/t]/cacttgacatttcagatttcagatactcagattaggaaggctcaacccg tacagggattc[c/t]ggtgatgctactgtgctgcttagctacacggaacacattattttttcactgtattaatga/c/A K5/adenylate kinase 5 555/15/rs11161328/24462237/[a/g]/taagccactgagacaagtaggtttacaagtataaaacctttctcaat 30 ctcagataatcca[a/g]agtagaaaccccctgaccttagactgttattttaccaagcacacgcacaaacatgcacac/a /GABRB3/"gamma-aminobutyric acid (GABA) A receptor, beta 3" 556/2/rs4953274/45936499/[t/c]/aaagcttctcactgcagtgggtgatgtattgccataaatgggctgaaca atgttttgccc[c/t]tgtgaggaggggcacaataaggctgttgactgctgcccctaacactgacctaccttctgt/c/P RKCE/"protein kinase C, epsilon" 557/9/rs10735625/70559994/[c/t]/catacttcaaaaaagaaatgttttccttttgttgtttgctgactttgg agactgctttcc[c/t]aaagaatccactttcgtttttactactgatctgtgtttttggatagcaccatggcacctt/c/ PIP5K1B/"phosphatidylinositol-4-phosphate 5-kinase, type I, beta" 558/10/rs7091519/121071784/[g/t]/ggattacaggcatgagccaccacatcttgtcccaacccttgacattt tagagccaaccat[g/t]ctttgttccaggggtctgtcctgtgcacagcgcaatatttaaccacatccttggcctgca/t 40 /GRK5/G protein-coupled receptor kinase 5 559/18/rs4625812/17525302/[a/g]/attaatagaattaaatggagaaacacaaaatctacaactatattttaa aatgcttctatc[g/a]ataaaagataaaagtgagctatagtctgaaaaacattatcaatagtaaccaaatttaaat/a/ ABHD3/abhydrolase domain containing 3/ 560/9/rs10739488/119059170/[g/a]/aagcattctttgaaatatttttgtagcacaacttatagaaaaaaacc tccacatttttct[a/g]tgggactcagtgcacatacacacaaagatacacaagcatcaaacgtttcagaaacaaact/a /ASTN2/astrotactin 2/ 561/17/rs1005631/53088372/[g/a]/atatcaactcaacaatgcatgtactacaactacagctacggctaccag tacatctactac[a/g]gtgcatgcatttagttcagtcccacagatacatacaatctaagaacaggcaggggaggtg/a/ MSI2/musashi homolog 2 (Drosophila)/ 50 (75) JP 2010-88432 A 2010.4.22 562/21/rs9979150/34163750/[g/a]/tgtcagacactgtgtgttgatattagatgattgttcttctcctgtcac tttgagaaagcc[g/a]ataccaaaagaaaaaagaaagaacaaaattagggtttcagtgtccccacctgtaaaatga/g/ ITSN1/intersectin 1 (SH3 domain protein)/ 563/5/rs10043664/54464067/[a/c]/ctgccaaactgcttctatgtctgattgtctcctttaaaataatattca agcatagtcttt[c/a]ctctccaaatcacctcctctgccaatctgtcttctcagtgacaccacccttctttctcct/c/ CDC20B/cell division cycle 20 homolog B (S. cerevisiae)/ 564/5/rs1021580/54475223/[c/t]/aaagtgattatctggttttaaaaaccaaattcaaagataaatgtctttc ttgtaggatcc[c/t]gcaaagaacaactgaagacccccagcaaaggaatttctgaaacaagtaactctgctctcc/t/C DC20B/cell division cycle 20 homolog B (S. cerevisiae)/ 565/3/rs3804797/3104632/[g/a]/ctgattaatattactactcaccttataaatccatcctttctggaatttac 10 tcctctgctc[a/g]gtttaggatcattagtgaatttaatcaatgtagactttccattttcatcaagatgattaa/a/IL 5RA/interleukin 5 receptor/ 566/21/rs2834380/34413370/[a/g]/ttgggcaaaagaggttctctacaatgaagaatatttgatcaaacagtt cctgtggaatca[a/g]tttcatagttgggctttgcttatgtcattaggcaaggctggcacttcacatatttttatg/g/ MRPS6/mitochondrial ribosomal protein S6/ 567/9/rs10491593/640373/[a/g]/ttaaagtgtgagaagcactgttttaacagagatctttaagccactttccc ttgctggaga[a/g]taaaagaggaatcgcactaaaaatgttccattcccctgatttgtctttatttcctgatct/g/KA NK1/KN motif and ankyrin repeat domains 1/ 568/19/rs2927707/8276921/[g/a]/tggaccttggggcctggggcctcgggctctggtgaggagctgacacatt taggatgggga[g/a]agtgataggtctgggaggaattcaggaggcggggcaacaggacttggtgactgagcagat/g/C 20 D320/CD320 molecule/ 569/3/rs9810902/2856134/[a/g]/aatggcaagttttttgcttttaccaaaaaaaaaaaaagacagtgggaatc acaacagaaa[g/a]aggtcggatgctgttggtgatttttgtacctctgaagcttctaaatatagaggggtttat/g/CN TN4/contactin 4/ 570/1/rs332833/61476951/[g/a]/gagaagacctaagtttggcagcgcactaagttgaggatgagaaaagaaaa aagaaattct[a/g]tcttttctggtgcttttccctcttggtttctccactaaaaatcaatagcgtggtcgatag/g/NF IA/nuclear factor I/A 571/13/rs2226042/59188076/[a/g]/tttttaaggtatgcaagaagataatgatactactgagcacttctaagg ataatcctttac[a/g]gaaagatgaaagttaaaaaaattttaaagtgggcataccacattaatgttaaatacattt/g/ DIAPH3/diaphanous homolog 3 (Drosophila)/ 30 572/13/rs1353523/59215544/[c/t]/tgcttggtgacaaatgtggtatgtatgtagtagtggtcgtgagtaagg caaaggaggaag[c/t]ttccaacatgggggagcaagttgggttggtgtttgggaggtgagataagaggacagagat/t/ DIAPH3/diaphanous homolog 3 (Drosophila)/ 573/1/rs11162326/77609077/[a/g]/ctccaaccccagcccagtccagctgggcaaacctgccaagcagtgcca ggccagcagctt[a/g]ggaaccagattctgggatcctccatcccagctgcacatagcttccagacaggccagggcc/a/ AK5/adenylate kinase 5/ 574/19/rs1599871/8454175/[t/g]/acacagctagaaaaaggcagagctgctcccaccccgggcagtctgtgtc agaacccgcac[g/t]tctcaccactaagctctacagtccccagcgataacagcctgttctaaaaaaacaaaacat/t/H NRPM/heterogeneous nuclear ribonucleoprotein M/ 575/17/rs12450102/73759875/[c/t]/ttggagggcacaaagagggtgcgccccagccctagcagctccacagc 40 catttcttgcagc[c/t]ctgcggagggacagggaagccgctgtgcttgcacactcgggtgtcagcaccgtccatgct/c /THA1P/threonine aldolase 1 pseudogene 576/13/rs913462/101246095/[c/t]/ccactaaatatttacaacatgaatttatctgtgactcacttgatgtac cgtgattgtgtg[c/t]gcatcctaagacgtgattcctgtactatggttgagtaattgtcatggcaggtttgcccct/c/ FGF14/fibroblast growth factor 14 577/16/rs5882/55573593/[g/a]/cttctgtgctccagggaggactcaccatgggcatttgattggcagagcagc tccgagtcc[a/g]tccagagcttcctgcagtcaatgatcaccgctgtgggcatccctgaggtcatgtctcgta/g/CET P/cholesteryl ester transfer protein 578/9/rs17095/74396157/[g/a]/tacccgggctactgcaatagccttgtaattattcttctccatattcacact tccttctac[g/a]gtgaatctcaatcctgacacactttataacctactgggagccaacctaaactaattaaat/g/TMC 50 (76) JP 2010-88432 A 2010.4.22 1/transmembrane channel-like 1 579/17/rs642612/74033121/[t/c]/accagcgtggggactgactcccaatgggcatggtaaatgcctcatttcc tcctgagagtt[t/c]ctgatttcccagcatttcttcaactttcatattatatttttatcttattaaaaatgactt/c/D NAH17/"dynein, axonemal, heavy chain 17" 580/18/rs585632/55285808/[a/g]/actgtcctcgtggtgggaaacgtttttgtttccaccatgcggcagggga gcaagtccatg[a/g]tgtgcatagttaacatgggctcttcatggggacttgtttgatggtcccatggctcatttc/a/C CBE1/collagen and calcium binding EGF domains 1 581/11/rs10501426/77734770/[a/g]/ttatttttaattttttacagctgtcgagttgattgtcctgggtctct gtaagcaaactct[a/g]ttctctgtgatgcaattatttgctagtgagaaatttatctcatgggcaacagtgagactt/a /GAB2/GRB2-associated binding protein 2 10 582/21/rs2837286/40198160/[c/t]/ggtgcaagattatctttcaagacctacgtgctgacttaggcagatttt gcttaggatata[t/c]tttatctgtcaactctccttggtatgtggaattgtgtggagtaaggcttcgtgtgcaagg/t/ PCP4/Purkinje cell protein 4 583/15/rs12898794/72671500/[t/c]/agtaagagggaaaagcagttattcacagaggaggagccagaggcctt cagagagctgctg[c/t]gtttccccaccagccattaccccagcacctcactggatgtaggcaagagcagggcaccgt/c /ARID3B/AT rich interactive domain 3B (BRIGHT-like) 584/7/rs848019/12395075/[t/c]/ctgtttacattggtcaaatttctttagggttctttgccaagattgtaaag tccccccaca[c/t]gtgaaagcatcaaaacagacatctcacatttttccactggacataatgattgagtgtgtt/c/FL J14712/hypothetical protein FLJ14712 585/14/rs712408/41345673/[c/t]/agtttggctatggattaggactggggattcatttcaaataaactgaatt 20 ctggggataat[c/t]cagctaagcagataccctccacacacaaacaggaagtacacctgcctgcttaccgtacac/t/L RFN5/leucine rich repeat and fibronectin type III domain containing 5 586/6/rs4413610/42176953/[t/c]/tattcatcacccaaagatgccatttgctgagcaactactaagcgctagg cacgtgctgga[c/t]gctttgcctaaatcagtatgtcaccaccacaagaggccttccctgactaccctgttaaag/t/L OC100128918/hypothetical protein LOC100128918 587/6/rs9388724/130041921/[c/t]/gtttttaaaagttgaagtccagtgccttacttacattattctgaatat caattgtctcta[c/t]agaatactgtaggcataggatccatttgggttttatctctactgaccctaaaaacacact/t/ ARHGAP18/Rho GTPase activating protein 18 588/7/rs12673082/107798557/[t/c]/taaaatacagcatctttcataactgcttcttcacaccttacagaatt catatatacttgc[c/t]gtcatattaataatatttctccaaccaggttctacttacatctgcctccaaaatttgctc/c 30 /NRCAM/neuronal cell adhesion molecule 589/9/rs3124297/136756536/[a/g]/ctcggcgggggaggtggtgcctctgcttggatggagtgaaggttccga tgaaccaggctc[a/g]ggtgaaccaggctcgggtgaaccaggctcgggtgaaccaggctcggatgaaccgtggaga/g/ COL5A1/"collagen, type V, alpha 1" 590/10/rs653295/117180403/[a/g]/tgattaagcctctaaatcaggatttctcaacctaaatactattgatat ttttggccacat[g/a]attttttgttctggggaggttgaccttttcattgcaggatgtttaccagcatccctagcc/g/ ATRNL1/attractin-like 1 591/3/rs1588669/28333958/[a/g]/ctttaccatataggagtaaaagttcattctgtgacttaatattctttca gttctattctc[a/g]agtgcttccaagaaatgtttactgagtaaacgaatctcttaaacttttgtatgactgaat/g/C 3orf68/chromosome 3 open reading frame 68/ 40 592/2/rs3770241/45475131/[g/a]/gtaatcaggcagatagtgatactaatgccctcaaatcctttcctctagg gatacctctgg[a/g]atacaaaaagagaaaaagggaattgttggaggtttgtctataatcagaatggggatatat/a/S RBD1/S1 RNA binding domain 1/ 593/5/rs17160324/107012707/[a/g]/aacacgacttgaccaaggttaagtgacttgcccaaggtcaaacagtt aaatagtgtcaag[g/a]ccttaccacatctcggatcttctaagtgagatgctctcgcctaagagatcgactaattca/a /EFNA5/ephrin-A5/ 594/14/rs2064922/51132891/[a/g]/agagagagcaatgaacacaaaatattttgatatgatcatttgacaggg tcttagatagta[a/g]gtatcagcttataatagaatttaaatcacctcccaacctcaggcttacacggttcacagt/g/ FRMD6/FERM domain containing 6/ 595/5/rs10515691/152915585/[a/g]/gtacacttcagcaacttgataactcttccccagctgaaagtcgaatc 50 (77) JP 2010-88432 A 2010.4.22 atttgatccaacg[a/g]gaaagaagctaaaattgtcctgacagctaaagagcgatctgacctttgtgatcaggagga/g /GRIA1/"glutamate receptor, ionotropic, AMPA 1"/ 596/2/rs1533949/36634524/[t/c]/ccacccatcctgaaagttcacagctggttaactgttcctcttccttggg gaccaataata[c/t]gacactttgcccgggagggggatattgctcaaggggagaatactccttccccttttttgg/c/F EZ2/fasciculation and elongation protein zeta 2 (zygin II)/ 597/1/rs4920338/18863380/[t/c]/tcagtggcagagctgggacagattcccttttgttggaaagatgatctcg tgcctctgagg[c/t]ggtagtgacctctctcctggcccctgtcagcctatggccacatctgagtttttccttccc/c/P AX7/paired box 7/ 598/3/rs17029181/32321120/[g/a]/tagtttacttctgtctctccatagagaaacctccaaggcaaatatttg tctggagttagt[a/g]gcctgcaatgattaccgaaggtccagatgaggttattaaaatgcctggtgtttgccctgg/g/ 10 CMTM8/CKLF-like MARVEL transmembrane domain containing 8/ 599/2/rs1470414/241726169/[a/g]/tttacagctggagcacaagaagcttttatgataagcacggggcttttc ctccagggcacc[a/g]tcacgtcatgtgacagtctctttgctcatcttcacgggtacgtgtctggggaggacgtgg/a/ PASK/PAS domain containing serine/threonine kinase 600/9/rs1800977/106730271/[t/c]/ggctttgaccgatagtaacctctgcgctcggtgcagccgaatctataa aaggaactagtc[c/t]cggcaaaaaccccgtaattgcgagcgagagtgagtggggccgggacccgcagagccgagc/t/ ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 601/2/rs13008370/212350619/[g/t]/ttacagggttcctgcctaaatgaatcatcatccaaggatttacaaaa aattatagccttg[t/g]caccccaaccattatagctatcataaccctactcaacctgtactcttacatacacctcat/g /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)/ 20 602/12/rs2302688/15564370/[t/c]/ttacttattaattttttatgaaagtaagtctactccaaaaatagtact ttctcccacagt[c/t]ttttgtctccttgcttgcttttctcattcagagaatagctaatctgctgccagcatggta/c/ PTPRO/"protein tyrosine phosphatase, receptor type, O"/ 603/5/rs6893150/80545692/[t/c]/tctagggatcaccagctatcaccaagggatccctaaatcttaaagtttc caggcccactc[c/t]gtagttaagtgatattcttgtctttgataggatgctggtttaggaataaccgaactgatc/c/R ASGRF2/Ras protein-specific guanine nucleotide-releasing factor 2/ 604/4/rs10516558/110669445/[t/c]/gtagtcctagagaaagagagttattaatactaatttgggaaaaatta taatagcatttac[c/t]gaaggatccaaatttttttaaataacagaagcatttaatcagtcctggtgtggtggccca/c /SEC24B/"SEC24 related gene family, member B (S. cerevisiae)"/ 605/4/rs13145066/110664667/[c/t]/aactcatcaacaagtgtagctggcatttagttcgttgacccattaca 30 atccattataaat[c/t]actgtggtgttttgaacacaggaagctgatatatatttactgaatcctttgatagagctt/t /SEC24B/"SEC24 related gene family, member B (S. cerevisiae)"/ 606/3/rs802792/9199175/[a/g]/agccaaggcacaccagaagccagaaaagaccaggaaggattttcccccaga gccaacagg[g/a]agagcgaggccttcctgatagagtgatttcagacatccaccctccaaaaccatgagacaa/g/SRG AP3/SLIT-ROBO Rho GTPase activating protein 3/ 607/8/rs1450136/51390059/[a/g]/atgagtttaatgctgtcaatctatcaaaacactatagttagaaccagta ccataaggggc[a/g]taaaaactgtaacacattgtcttgctctcaaggtaatgatcacctagtagacagaaaagt/a/S NTG1/"syntrophin, gamma 1" 608/9/rs3109676/136771019/[t/c]/tccttctgcactcaaatccacattcattccaacagcaggaagagaaaa ctcccgccccgc[t/c]ggacaccaggaggccgcagtacttggagcgcccaccaggtgtcagaaggaaatcgcggca/t/ 40 COL5A1/"collagen, type V, alpha 1" 609/3/rs4141499/129124658/[g/t]/atttctctccttctgctgtgagtaccacatcaatcatttctgctaatt ctttcatgttct[t/g]aattttattcagtaaattcaagctatgttggtatttttcttttccctcaatcttgcactc/g/ KLHDC6/kelch domain containing 6 610/17/rs12937692/39611956/[a/g]/ctagtggcccaccacctccctctcctgccacccttatacctgttcag cctcctaaagagg[g/a]acaaactctgtctctgcgtgcactggcttgcctgccctgcctttgtcactccaagggaga/g /C17orf65/chromosome 17 open reading frame 65 611/11/rs1212146/64169453/[g/a]/ggggagatatagagggtaaaaaagaagggaaagacagaggtatgtaag agatcaatagag[a/g]ctgcagagatgaacggagacagggaggcagagatggtaaggaattgaccgcctgggagag/g/ NRXN2/neurexin 2 50 (78) JP 2010-88432 A 2010.4.22 612/1/rs2602936/77600500/[g/t]/atcacagtaaaggatagtttacttaaaatgtttgcaactcaccctcaag caatattgaca[g/t]tcttattttcagatcatttcacttcagtgagcacaatgttttaatttttaaaaacgtttt/g/A K5/adenylate kinase 5 613/1/rs2815307/77604838/[g/a]/atttgtttcatccctgccaagatgcaaagcccatgcctggtctctctac cacaccattct[g/a]cctctaccccaggaataagggttgcaaagctttattttcacagtgagcaccaaagtgtat/g/A K5/adenylate kinase 5 614/3/rs604300/128925542/[t/c]/agggttggtttctcctgcaggctctccttgccttgtaaatggctgccat ctccctgcatc[t/c]tcacataatcttccctctatgtctgggttctaatcccctctccttacaggacaccagtca/t/M GLL/monoglyceride lipase 615/5/rs252818/106753590/[c/t]/tgatactgtgactattatactctaatccttagaaaaatttgtgaacaaa 10 gaatattagca[t/c]acaatgtgatatgtgagtacacaacacagattgcatgccatggattcactcgatcatcac/c/E FNA5/ephrin-A5 616/9/rs10521449/74412721/[a/g]/ggtaatgaaatcattttaacataagactacatgatttggacttcattg tgtggtcacttc[g/a]gagcattttagcaacaaaataatgtcttaggaagattaatctggtccaattgtaaagtaa/a/ TMC1/transmembrane channel-like 1 617/19/rs2277987/8458273/[c/t]/ggccccacaccagctgtgctgaggggaaagcgacctcgtctgggatgta tttatttagcc[c/t]tgccacctagaagccaggtaacctcagaaggaagactctgcctgactcatctgtgaaatg/c/H NRPM/heterogeneous nuclear ribonucleoprotein M 618/3/rs7624893/16408305/[a/g]/cctgaactaatcaaataaggctctttgataatgaaggggaagtcattta aaagctggatt[g/a]accatagactcacagaatatcagagctataggcaatcctagagattatcattctagtgca/a/R 20 FTN1/raftlin 619/14/rs2268474/80594160/[c/t]/gatgaaatttcagtcaactaagcctagtatcatgcaagattactgtga aaagtttaattg[t/c]accaactgctcttgtttggaacaaagaactgtcagctctctttacattaaccatatttct/c/ TSHR/thyroid stimulating hormone receptor 620/20/rs6079381/14212636/[t/g]/cataggcccaggttggaaatgcttacatgttattaagcatttatgtaa tttgggaatttt[t/g]atcattgtcaaagcatgctagaagcatcattctttcagctgcccttagaagttgcttcta/g/ MACROD2/MACRO domain containing 2 621/18/rs2644262/32477564/[c/t]/ttgccagttaaacctatatatcctcgtatcaacaatatatgaattagt tgacttgcattc[t/c]tttcatcacttggtatcattagacttctaattttaccaagtagatagaaaatggtatctc/t/ FHOD3/formin homology 2 domain containing 3 30 622/17/rs11080209/28616992/[g/t]/ccattgtctattcattgttttgtcttcctcatgtggcagggaagatc tctatgttcaaag[t/g]atattgaccctcttctcaacctcatcttgagtttctcataacatggaaactgaaatccaa/t /ACCN1/"amiloride-sensitive cation channel 1, neuronal" 623/14/rs7145427/73553201/[c/a]/ataactaaggtactacgcatacattaataatcttgttatagtcaaatt tttatgttcata[c/a]attaatctgtaagcctatgttcaaatgaggagtcttggactgactttcatattataaagt/a/ ENTPD5/ectonucleoside triphosphate diphosphohydrolase 5 624/6/rs9403527/144089526/[t/c]/aaatccattcattggtcagtggacatttgggctgcatccatctcttgg ctattgtggata[c/t]tgctgctctgaacataggtgtgctgtaattagttttatgttaaccattctagtaggtatg/c/ PHACTR2/phosphatase and actin regulator 2 625/2/rs713397/201065869/[c/a]/catgtgtaacatgttcttattgagagagtgattctaaaattactagtgg 40 acacagtgggc[a/c]tgctgtggtaaatatttttgctccacagaagtggaatcccaggctttactggcaatagta/a/K CTD18/potassium channel tetramerisation domain containing 18 626/10/rs7093628/126227457/[a/g]/tccccggacaccgaggctagctctttctgctgtggccttctcacaga ccaaggtgggatc[a/g]cagccttggtagccttgaagtctccctaacctggcaagacagtggagaagggggacagcc/g /LHPP/phospholysine phosphohistidine inorganic pyrophosphate phosphatase 627/7/rs13230414/147272274/[c/t]/ttagaaaatcagatcagcataagaactttatttttaacaaatattaa tataaaagtatta[c/t]gtgtttttctactgcccatatctgttctgtccaagccatgtgcattcatgttaaataaat/t /CNTNAP2/contactin associated protein-like 2 628/13/rs770266/32576065/[g/a]/ggtatggtgcgaggaaaatcttacagtttgaattatgacctagaaattt ttcattcccat[a/g]tctacctaagaaggaagcagtaaatccataatttaccttttgggcaatgctttgtgagca/a/S 50 (79) JP 2010-88432 A 2010.4.22 TARD13/StAR-related lipid transfer (START) domain containing 13 629/14/rs2287652/77467201/[g/a]/cagtggtaagcaatggagcgtgagcagcagcatggtctggcagggtgc aggctatggggc[a/g]ggactttggagttgggttgaagtcaggtcagcctgagctaggcttggaggggtaggagac/a/ ADCK1/aarF domain containing kinase 1 630/5/rs305641/83705071/[c/a]/ccatctctggcactaagaaaatgagtactatcaaaaagtgatagcatcta tagatcctgg[c/a]agggctgaaaggttgaattgggttttaaagggaatgaataagaagacaggaagtgatggt/a/ED IL3/EGF-like repeats and discoidin I-like domains 3 631/11/rs1790080/72614922/[a/g]/ggcttccagcagggtggggaagagggaggttgtccaggctgtatcaga ggtttgaaacct[a/g]gaaggatggtgggggcccttctcagaaatgagaaccacttgtggaaagtgatattctcca/g/ P2RY2/"purinergic receptor P2Y, G-protein coupled, 2" 10 632/6/rs4706623/77347880/[c/t]/cagagtaaggccacctatccctgtctcggtaggttttttgggtatgaat tctgagctaaa[c/t]attaaacagtgtataagagtgaaatcagtgaagtcagaagtgggttttaagaggagggag/t/L OC643281/hypothetical LOC643281 633/1/rs12140071/19983023/[c/t]/aacccacgtttgagatttgcagcaaatttccctggctcagagggtcag ctcagaccatgg[t/c]ggtgggaacaggggcaacagcataaaccatgaactaagggcagtgccaagggcagcacta/t/ TMCO4/transmembrane and coiled-coil domains 4 634/5/rs17160255/106979256/[a/g]/cgaaatgcacaagtacagattcccattatgcatcctttcctctctgg tttctagagagca[g/a]accaaaaaacaaacaaacaaaaaaattctcttgcactctaaaagcttgcttcacttaaaa/a /EFNA5/ephrin-A5 635/19/rs3745386/7883870/[a/g]/gccacctcctgacgggtcccctgggtctgcataggtctcccatggcgca 20 atgagtcagtg[g/a]cccccagccaggcagtgtgggcattgccactgcggctggacggggctgcgcgctcgcgct/g/M AP2K7/mitogen-activated protein kinase kinase 7 636/13/rs4886119/52518118/[g/a]/gccaaatgtgatcgggtgctcaggggttgatctccagtttgcttgggg atgcaaggttct[g/a]tgctggtccatagtgatgctcagtaagtagctgatgattaaatggggtctgaaagaaatg/a/ OLFM4/olfactomedin 4 637/5/rs12655663/147645416/[c/t]/aatcaatggacagtgtgaaaacagtgaaaaatttgagcacagagcaa attgcgtgaatta[c/t]gcatagcattattgctgtggttatcttttacctcttggtaaaaaaaaatctggtatttct/t /SPINK5L3/serine PI Kazal type 5-like 3 638/4/rs1372491/46804117/[g/a]/aaaaaaagggatcgagcctctgggatccttgctaaaacttttctgatgg gtggatataca[a/g]cctctacttgacacttctctcaactgctcaccaacctaattactttcctctggacaaatt/a/G 30 ABRB1/"gamma-aminobutyric acid (GABA) A receptor, beta 1" 639/1/rs7531293/33720054/[c/t]/caccatcttgttgaatccccctctctgtcagatgccccctctccatcag gtgcacaggga[t/c]ttttaaaaaacaggctttattttttagagcaattttaggctcaaactcacagcaaaattg/t/Z SCAN20/zinc finger and SCAN domain containing 20 640/12/rs7958562/106261538/[g/a]/tggttttctcttttacaacagtccaaggcaggtaggcagtccaaagc tgggatggttatt[a/g]tattagtccattttcacaccactataaagaaatgcctgagactgagacatatataaagga/a /BTBD11/BTB (POZ) domain containing 11 641/7/rs2242493/142738658/[c/t]/catctcttggacataactactgcagggaaacaaataccaggcttctgc ctttcctatctg[t/c]ccacatccccccagcaatgtactctatctgtgccaaccgcaccttctttctagcttgggt/t/ CLCN1/chloride channel 1 40 642/10/rs1264782/116874783/[a/g]/catgttgactttcatcgtgagtaaaagtatgaagtatgggggtcaga taggacattctag[g/a]gagagaaaagcatatatacaaaggtatagacacattaaagagcattatattttagggcaa/g /ATRNL1/attractin-like 1 643/7/rs10261782/104800211/[a/c]/tactgagctatataaagcataatacaaactatgaaaggttcctttgg agacatacacaac[a/c]accaaataaagcaccccaacccaaacaaaggaaagaaaaaactctctgagcactaactat/c /SRPK2/SFRS protein kinase 2 644/11/rs605093/128109442/[a/c]/tttccctatgatcttggtctctgcacacgcacgagaatagccttcttc catctgagtact[a/c]agctcgatcctgcttagcttccaagatcagatgaggcacgttcagagcactgtggacatg/a/ FLI1/Friend leukemia virus integration 1 645/18/rs7505745/4089242/[a/g]/attatattatttctacacctcagctgcttcccagagagcctggaacttg 50 (80) JP 2010-88432 A 2010.4.22 aaaatagatct[g/a]tctgtctgtctgtctgtctgtctgtctgtctatctatctatctatctgtctatcatctat/a/L OC388458/hypothetical gene supported by BC040718 646/17/rs7215616/28547280/[g/a]/gatacctggcacagagtgagccctcagtgaaaggtctgagcaggttga gtagctcatttc[a/g]tcgttcctaaaattccttgttagccctattttgcaagtggaacttggagaggttaaacaa/g/ ACCN1/"amiloride-sensitive cation channel 1, neuronal" 647/16/rs7199993/11766842/[a/g]/aggacaataccactgggcttgcaaattcaactttacagtggaaaataa gttttggagaac[a/g]cacctcacaaaggaatataaattccccaagatgctcctggagaagtttgaacacagtaag/a/ ZC3H7A/zinc finger CCCH-type containing 7A 648/17/rs8077720/30474212/[a/g]/ctccaaggaaggaaaggagttagccagtgaaggggtggtggtacaggg tgatgtgggctg[a/g]gggaattacttgcaggtcacccaccacatgggtgaatgacctgtgcagtcacaaatagcc/g/ 10 FNDC8/fibronectin type III domain containing 8 649/1/rs11801737/214559014/[g/a]/agcaaatgagagagactaataccgactgactagtcaacagaaagcaa gagaagctcagaa[a/g]agaacatatcatatgaaggtattagccaaactgtagcttgcaaatactagacatattcag/g /USH2A/"Usher syndrome 2A (autosomal recessive, mild)" 650/3/rs1447675/74233758/[a/c]/tgatgggatagcctataaactacgagtgtttctttgacctgcctctctt agaaatactct[a/c]tctgtctagtcttctttaaagtggaggatcactttggtgccactgccaatgggatcaaca/a/H SP90AB5P/"heat shock protein 90kDa alpha (cytosolic), class B member 5 (pseudoge ne)" 651/18/rs752798/19988834/[a/c]/ctgttgtgaccttccaacccatgagaattttcctcatgcctgaggattc actta[a/c]ggctacactttcagatccagagatatctttcttttcctcttggctgggtcagtctgactt/a/CABYR/c 20 alcium binding tyrosine-(Y)-phosphorylation regulated 652/5/rs10514865/58711295/[g/t]/aatttgggatattaaaatatttatattcaaagatattcaccgtaaaaa tacctataatat[g/t]gagaacctaggtatattctatgtatttcacatgaactaatgtttaaataaattttcatat/g/ PDE4D/phosphodiesterase 4D 653/1/rs6693481/202033018/[c/t]/accaactctgtgactctgggaaagggggactcagttcttacttctgta acatgaggacac[c/t]ggactatttgaattcagaacttagaaaattggaagggaccttaaagccctctaagaaaga/t/ ZC3H11A/zinc finger CCCH-type containing 11A 654/2/rs3770283/45610993/[g/a]/ttattaatcaagctttggactagcctgtaattaatatatttgaatgaca acacaacacta[a/g]ggccaattcatgtgctataacaatgctgatcctaaattacgtaggatacacaaaacctca/a/S RBD1/S1 RNA binding domain 1 30 655/2/rs4671277/56337668/[t/c]/ggaaagggaaagagcttgtttatagggggaacattcaactgaagtccat atagtactgcc[t/c]ttctgataccatgaatgtcaataaactcactctccatggctcagtgtatgatagacctca/c/C CDC85A/coiled-coil domain containing 85A 656/18/rs2469478/45905535/[g/a]/ttgatgcatctcttaacattcattgttcagtttgatatttagaaaggt gtgcagcatagt[a/g]cccttgagaaagagaagctgtaaaggtaggtttgcgctctgttcaataccattcaaatgg/a/ MYO5B/myosin VB 657/20/rs2206481/9723551/[t/g]/ggggatacagactgtcatagcttcatgagaaaaaaaaattaaaatgtgc tgtaggaaagg[t/g]aatgagagtgagaagaaaagccatccaggggatctcatatactgaagatatggtttttct/g/P AK7/p21(CDKN1A)-activated kinase 7 658/3/rs9850440/53261728/[c/t]/acagtatgtttccggaggggtaacggcggtgaggaaatcagactttgcc 40 taacaaagaac[t/c]aggagacacacttgacattccactcttttggagcaccctacatttgtaaatcttatttct/t/T KT/transketolase (Wernicke-Korsakoff syndrome) 659/3/rs10937432/191642994/[c/t]/cccatcatcataccagtcagaaatgacttttaacatatgtgaagtgt caatttaaaaatt[c/t]tatcacaaacatttaagacaaaaaccaatcacccagcctacagatgatttcattcccctc/t /UNQ846/SRSR846 660/17/rs3736143/30487681/[c/t]/cagcacaccctacgggagagcgagtcaggtcagacacacacactcctc cccacgcctggg[c/t]gattagccccaggagacaggtggtacaagactaataatcatcatcactcatgcattgtga/t/ NLE1/notchless homolog 1 (Drosophila) 661/18/rs11660303/17668757/[t/g]/gtctgggaaactgtcacaaccaaagggagctaaggagaaaagacaac taaatgtaaaggg[g/t]tattctggaacagagaaagaacattgaataaaactaaggaaatctcaggtgtggactttg/t 50 (81) JP 2010-88432 A 2010.4.22 /MIB1/mindbomb homolog 1 (Drosophila) 662/14/rs11844935/30734018/[a/g]/aatgaaatattttaactgaaaaacctgaacacatctggtttcttaaa gacaataaataac[a/g]caacatcttttgatccatttcatattccatttttgcctctgctcccagccttgactttct/a /HECTD1/HECT domain containing 1 663/3/rs7651591/6898647/[c/t]/gattagtctaaggcaattgaattgtgtgtgtgtgtgtgtgtgtgtgtgtg tgtgtattag[t/c]atgagctgaaacttgtggaagtccaccttaaaaatatagataaatccaactgtggttcac/t/GR M7/"glutamate receptor, metabotropic 7" 664/14/rs1147465/68863377/[g/t]/cagggtgatgaatagagcagccatggctccaacctgtggggcccaacc caaaggccagcc[g/t]cctactcatactcatactcccttcctgcgagaccccaggcctggtcagcatggggaatag/t/ GALNTL1/UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra 10 nsferase-like 1 665/12/rs3759193/51114706/[g/a]/aagaagcaagttaattgctttccgtcatgtgctaatgatgcatcttgt aaaggactcagc[a/g]aacactgcctcatttctaaaccgctttcttaggcctgggaccaactccgtcctgtccaaa/g/ KRT75/keratin 75 666/3/rs13326165/52507158/[a/g]/cctgatctgaccaaaggtagggggaagcagtttggggttccttcctct ctgacagggttt[a/g]gattctgggctctcagccttaaaaagtccccatgaaccaggtcccagcttgggagaattt/g/ STAB1/stabilin 1 667/3/rs1867525/125459020/[g/a]/cattggcataaagtggtgaaagtgcttttctgagatagcacaggctta ctaagtgaaaac[a/g]gccccagtggcatttaatgaacaaaagaggaaatggtacaagaaa/a/KALRN/kalirin 20 668/22/rs916257/41961296/[c/t]/tggggtgagctatagggacgcacaggacactggttctggctccctcctg cccatctcacg[c/t]gggggaccatgtaggggagggcttctgggtgggagcagagggagggcacagggtcatggg/t/S CUBE1/"signal peptide, CUB domain, EGF-like 1" 669/7/rs10808265/131840229/[a/g]/ttgcaaatggtgccatcggggcaacacagagcctggcctggccgatg tcgcacgaaacac[a/g]tgtggtctgagccgactccaaaggaatcgtaacaggagggtgggagcaaaggaactcggg/a /PLXNA4/plexin A4 670/8/rs4076358/144982227/[a/g]/gtcctcaacccttacatcctttctctctggagtgcccctcaaaggtca cttactcctgtg[a/g]cttcaagagaaaggacatagtagaaagagtggagttagccagtcctgtgaatcacacact/a/ PUF60/poly-U binding splicing factor 60KDa 671/21/rs2284612/35135749/[c/t]/gtcacctgaggtcaggtggcattttcttaagcctgttttctaaggcaa 30 atgcctcctact[t/c]gaaactagaaggcagataggttgagctcccctctttgctccggcagcagtggccaccttg/c/ RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncoge ne) 672/2/rs2894511/224174071/[c/a]/atatgctcatctttaaaatcattatcttggaactgcactttgctgtaa agttgaagcaga[a/c]tactcattgcagttgtttaaaccacagcctaagaagtgctaccctttgcttaactattca/a/ SCG2/secretogranin II (chromogranin C) 673/4/rs718913/173052775/[g/a]/tgtgtggtggtggaagaagtgacctggaatattaaaagtcagacagaac acttagaagag[a/g]ccatatatgatttaattttaattattgttttaagtagtgatgaatttggggactgtaatg/a/G ALNT17/polypeptide N-acetylgalactosaminyltransferase 17 674/14/rs6575101/89601545/[a/g]/tcttagtttgggttcccttagaagcagagcttgagccaagaatttgag 40 tgtaagcagttt[g/a]ttgggaggagcaagggatacaggtcggtgcaagggaaagtgaatcgaggaaggaaagtaa/g/ KCNK13/"potassium channel, subfamily K, member 13" 675/18/rs11564338/23972174/[t/c]/tactggcattaattcctagggccattacgtgattgggttgtcagtgg ggtctccagataa[c/t]gttgaagctaggaccttaaaaaaaatcaaccaaaaggtctaacatttatgttcaaaaatc/t /CDH2/cadherin 2 676/18/rs8094439/23966605/[a/g]/ccactgcagtcagaggaacaggactttgatgcttcatccctagaacca gaggtggactta[g/a]cccctcctaaagctatggatggcacaggagcagcagggagcagatacccaaacactaatt/a/ CDH2/cadherin 2 677/13/rs2476227/101378302/[c/t]/ctcagacaggaatagtcccaggttctggactgttcctgatgtcttta atcctcctcccaa[c/t]ggtaagacacatatgccctccgtcccgtttccctctttcatccccggtgacactagaact/c 50 (82) JP 2010-88432 A 2010.4.22 /FGF14/fibroblast growth factor 14 678/18/rs1789476/55297903/[g/a]/acagagcaaagtaaggcggggacccagccctcaagttgtatgcattca agttgagaagcc[a/g]ggatggggagcagatagaatcagagagacctagattttaatcatgcttctatgtcctact/g/ CCBE1/collagen and calcium binding EGF domains 1 679/12/rs1862013/14586144/[c/t]/cctgaaaaaaggagaagggcctccatgaggaacagacccagggactta acactggtactt[c/t]acactggtgatgttcctctaaccgtgttagcaattgagtatgcgatattcaactcaacct/t/ FLJ22662/hypothetical protein FLJ22662 680/1/rs2054017/77583700/[g/a]/taccaggtttcctgggaagtggtcaaggaatgtgggaagggct[a/g]c actgctatttagcaaggctgtatagaccaatgtttccctaattttagtacttactagac/a/AK5/adenylate kina se 5 10 681/13/rs9567327/31634085/[c/t]/aatttagtaagcttagttatctcatgttgatctggagctccagttgac agttatgcatgt[c/t]tttaatttaaaaatcaaaagtgacataacctaactgcaatttggaaagcaaaattattag/t/ FRY/furry homolog (Drosophila) 682/14/rs1956002/32480500/[g/t]/tatttagttcagctctcaagtggagcagaataacaaatcgcacacttt gatttaccttct[g/t]cgaatgccaaatggagacaggtgataaagaacgcactcatgcacaggctatgaagtt/t/NPA S3/neuronal PAS domain protein 3 683/9/rs4977732/20783445/[c/t]/cccggttgtgtgcaaaaagcctagagtttatacacagggaagtagttct gtgttaatttc[t/c]tggcattcctgggcgttagtgttgggctgttacttctgattggtctacagattagaaatt/t/K IAA1797/KIAA1797 684/11/rs609017/128088154/[g/a]/ttttaaacagttcacctcacaaatttatgccattcagtgatggacaca 20 ggattgaccttc[a/g]caatgatgtgtacctgaagacttccaaagaaaaagctgctataggtctgctcattagcga/a/ FLI1/Friend leukemia virus integration 1 685/19/rs2287887/7733955/[c/a]/gctcaaccatgtcatgagtggaggagtccttctccctgtcaaccccaga ccatcccccaa[a/c]acctccctgaaattcctgcaaggtcaggccgatctcaggctctgactcctttcactagcc/c/C LEC4M/"C-type lectin domain family 4, member M" 686/20/rs2249317/1480595/[t/c]/ttaatttccggtttggccctgttcccttgaaccacaagacaggtccatt tggtaaggtat[c/t]gggtacgctgcaactcaagatgattgactccccagttgatacagtctgtgacatctccgt/c/S IRPD/signal-regulatory protein delta 687/5/rs2652130/34027156/[c/a]/acaccccaattctcccattgtctaccatcccttcacagcccacaatctc ccatcctgccc[c/a]tgaccctgaccaaggccacaggattaaacaccaatggtttaaggtgagctgtttgctgtg/a/A 30 MACR/alpha-methylacyl-CoA racemase 688/6/rs1004700/166797002/[t/c]/tttagtataaatagaatcctgatgggcctgctccgggcttcctcacgt gcgcttgtttcc[c/t]gtgaaattcgtttcagccctgcggccacactgtgtcattctgacatcctgggacaaatga/c/ RPS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2" 689/20/rs6082056/212997/[a/g]/caggtgaaagcagtaactatggacatggacagaggggagggcagggcagc caggaacccc[g/a]ctctcaaatgtccagtcagaaagagagtcgggaactcccactccttgtgtctttccagta/g/C2 0orf96/chromosome 20 open reading frame 96 690/22/rs6519365/41903890/[c/t]/tagctaatcaacataggcaaccctgggcccagagcacagacctgattg taaagggtcaaa[t/c]gggaaaaaacaaggatgcgtggccttgtatctcctcctcttcctggtcagcccagagctt/t/ TTLL12/"tubulin tyrosine ligase-like family, member 12" 40 691/8/rs13265370/121723083/[t/c]/ttgacagcgcttatcattattattaatttttaagtaaactttaaaag tgtaacatacaga[c/t]ggaaaagttcacaaattgtaggtgtccacctcaactgtatttttgcagagaatatattcg/t /SNTB1/"syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic compo nent 1)" 692/16/rs1421090/52407671/[t/c]/gaccaggggaaggaggcagaaccagtcaggaggctgttgcaacagaga tgatggcagttt[c/t]ggccacggtgtaagaagcagaggtggtgagaagcagtcagatttttcatacattttagaa/c/ FTO/fat mass and obesity associated 693/16/rs9319508/75894385/[a/c]/gtattaagcaaaaacaaccacatgtcaagcttccccagaccttcactc aagccaaccata[c/a]aaaattatcaatgcaaccaacaagaagggaactcacacaatctcccattgtcaaatgttt/c/ ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 50 (83) JP 2010-88432 A 2010.4.22 694/2/rs1900270/80147385/[a/g]/aaaattaaaaatcaaactaccatatgatccaacaatgccactactagct gtatatccaaa[g/a]taaatgaaatcagtatgttgaaaagatatatgcacttccatgttcattgcagcgttattc/g/C TNNA2/"catenin (cadherin-associated protein), alpha 2" 695/17/rs7217359/16958902/[g/a]/ggcgggggccctggtatctcgctgcccaggcagcggccgaagccagca ggccagcctggc[a/g]tagcaggtgtgaggaggaacttcctggtcttggcagcaagtgaaaaaggtccttgttttc/a/ M-RIP/myosin phosphatase-Rho interacting protein 696/18/rs4940675/54198006/[g/a]/ggaatttgaagagtggtcattgcttctcatgaaagtgtcgccgtaact catgaaagtgtc[a/g]cctgtaacgaatcctagagggatgcatttctgtaccacggagggctcgagccgagacacc/a/ NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" 697/20/rs4239713/14472404/[g/a]/agttgaaaatatcattaagtcaaaaattttaagatagtattatatcaa 10 aacaccacttac[g/a]ttacaatatcagatgtctttgaagcacaagtccttctctctgtagataatacttagggaa/g/ MACROD2/MACRO domain containing 2 698/13/rs1322689/101270369/[a/g]/ttatatcggtgtaattaattctcatcttaaatctttttacctgctgt cagccaagaaata[a/g]ctaggaaagctgattttccaaaagcttgtggatcttagatgagaaaaatgatgagtataa/a /FGF14/fibroblast growth factor 14 699/10/rs10788250/123891702/[t/c]/tcccccgtggattggtctgctctgggctttcctaggtcgttatttc ttgggctctgtttt[c/t]ctctgtggagccccgagggagcaggcagcatgggttccagccctggctctgctcccacac/ t/TACC2/"transforming, acidic coiled-coil containing protein 2" 700/3/rs12487468/51364610/[g/a]/aatggaagtggtggaagtcagcaaaagaagtagaagcaattgtacaag aactagaaacca[a/g]aagcatttccagaaagtcctttgacaaactaatgattctggtcttgtaacttgccttttt/g/ 20 DOCK3/dedicator of cytokinesis 3 701/12/rs928993/51084631/[t/c]/gtagttttcttgacagacaatgcacgatgtggaaaattccagagcaagg gctggagacca[c/t]gttcccttagtcaatgtccagccgggtggccatggtgaacttactcaactcctaatctca/t/K RT82/keratin 82 702/16/rs8055188/52247388/[t/c]/tggaatcatggtagaaaggaggtttaggcagagcaaacagcaagaaca aaggcatggcag[t/c]gggcctgagcatgacatatctgcaaagagcaggtggaggacctgtttggctgaggtgcac/c/ RPGRIP1L/RPGRIP1-like 703/8/rs6992115/40820923/[c/a]/ataggtaattttatgtgtcaacttgactgggctaagggatgcccagaga gctggtaaaac[a/c]gtatttctgggtatgtcaatgatggcgttcccagaagagattagtgtttgaattgcgtag/a/Z MAT4/"zinc finger, matrin type 4" 30 704/5/rs2662503/22507055/[t/c]/ggttgttggcagaacacccacgtgttaggagaacattcatacctttagg gagattgttca[c/t]tgggtgttgaaagaacaggtgcaatttttctcctgaatgcttcctgttttctagggaact/t/C DH12/"cadherin 12, type 2 (N-cadherin 2)" 705/2/rs2457390/145647932/[c/t]/taccgtggtacttagccattaacactcctgttccttgaggatataaca gtcattgtccaa[c/t]gtgttgatttaaaaggcaacaacctggatcagatttcactatggcacatcagaataccag/t/ LOC730124/hypothetical protein LOC730124 706/2/rs2697329/145608897/[c/t]/ttttcatcatatgtcagctggtctaaaactttaaattgattaaagcta tacatagagggt[c/t]tgagcctccataggatttgccacttgtacatggcacatgttgctctaaacagtcatatct/t/ LOC730124/hypothetical protein LOC730124 707/2/rs787435/145604839/[a/g]/ttttctggatctagaaattaataagtagcccctaatcccaaagatatta 40 tgctgccctca[a/g]tccacataaatatcaagtcccctggctgcctctcttgtcacctgatacctgcatgccttt/g/L OC730124/hypothetical protein LOC730124 708/3/rs13091545/52352334/[g/a]/aagagataaagtcaaaggagggaaggaagtcaaggggcggcttctaat gtgggacatacc[a/g]gagtgtgtggggacccctgggagggcgtgggagggaaggcaaagagactgaggtggctga/a/ DNAH1/"dynein, axonemal, heavy chain 1" 709/3/rs9854418/187759087/[c/t]/agcagaaactgtagcgtgtccactgaaagctgtccaagaagaaaataa aagatgaataga[c/t]gttttaaaacatcaaccactagtctaacaactaagtagacatagtaaattcacaagttgg/c/ TBCCD1/TBCC domain containing 1 710/1/rs178397/176448177/[t/c]/tgttgtttttgtggtcttcatatgtgagctttgtgatcttttaatgatc atgccagctaa[c/t]ggaggaactggtaagaggcggcagtataataaacaacgcgaaggaagtgagatgatgtag/t/R 50 (84) JP 2010-88432 A 2010.4.22 ASAL2/RAS protein activator like 2 711/9/rs7875140/136753593/[c/t]/gggcacccaggtgttcagggtcccctccctcacctgcatgtgtaggga agaagcagtggg[c/t]gggctggaaagagccctgggccaggatccaggtctagagcgaccctgcttctgcagcact/t/ COL5A1/"collagen, type V, alpha 1" 712/9/rs6478750/128449019/[c/t]/ggctcctaacactgaggtcacagtctaacaagggggtagggggtggaa cacacaatgtga[t/c]aggtgctctagcattaaggttcaaggggtcgttaaaaggaaagactaacacattttgctt/t/ LMX1B/"LIM homeobox transcription factor 1, beta" 713/5/rs10514862/58833329/[c/t]/tgcacatcgcttccctgttctcttgctgtgccagtctttccccagtgt agttaggtagtg[c/t]ctccaatcagtcaccatcaccatactgtgctgattttatattctgaatattttttaagct/t/ PDE4D/phosphodiesterase 4D 10 714/8/rs10095917/56992814/[t/c]/ctccactcacatggagacagggccctgccttttaggcacttactcttc cagtgtctattg[c/t]ataatatgttcaggaaggatcccagattcaaagatttatagaattagagttaaaagggat/c/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 715/1/rs7513108/161430401/[g/t]/tagtataaatgtagtcagtggtgccacacccccaaagtcacatgcgtc tgtgtttacttt[g/t]ttatcttgccctcagtgacattatacacttgaagaggaaaaaatgaagttaactgtaaat/g/ RGS5/regulator of G-protein signaling 5 716/7/rs2267875/123172017/[c/t]/tagagacgtagtttaatgttttattttttcctattccttagtttctca cttattcaggac[c/t]atatatgttgaacttcacttagcaaaactgcacatactctttatataaaattaactgaat/c/ WASL/Wiskott-Aldrich syndrome-like 717/7/rs6949474/48300488/[t/c]/gggcttcctactgcctctctagatctagacctttgggtccacctgtata 20 cacttatccag[c/t]atttcttgattctaggcctgatgtagccggagaaggagagtctgataggtgctgcctttt/t/A BCA13/"ATP-binding cassette, sub-family A (ABC1), member 13" 718/3/rs1347852/61055822/[a/c]/gtagtaaatggatagattaattgatgaatccctgccatttttctgatag tgtgtgccata[a/c]gtagttagagaaggctcaaaccttcaccaccatctgaatataatagtctttgcaaatact/a/F HIT/fragile histidine triad gene 719/2/rs728005/178959252/[c/t]/aaaagatgacagatcatttcttggtcatcaccaagaatcaggcatcttg tggagatggca[c/t]gaagttcccatagttcatcaaaatggaaccaggtggttatcacaaatgcacaaataaatc/t/O SBPL6/oxysterol binding protein-like 6 720/19/rs8104920/57357072/[g/a]/attccaaaagggagaaacaggaaagaaggggtagctgttcccatgtaa ggctgaaaccca[a/g]cagggcatacacattaaacactaaggcttgacaataatctttgactccgtgtcccacctt/a/ 30 FLJ16287/FLJ16287 protein 721/6/rs568129/84285833/[g/a]/caaaattggaatttgaagccccaaatgcaagccatctggaaatggacagt gaaggtcaca[a/g]ttatattggaagacaggaaaaatgagggggatggggaagccaagggatgttagactttca/g/PR SS35/"protease, serine, 35" 722/6/rs490132/84324923/[t/c]/atagactagaaaatttctcctgaagccagttatggccagtaatggccatg aaggctaggg[c/t]ttctcacattctaaatttctgtctttcaacatccaccattctttctcttggtccctgttg/t/SN AP91/"synaptosomal-associated protein, 91kDa homolog (mouse)" 723/1/rs3002686/3167971/[a/c]/tgagaaagctgaggcctttgcaaagtctatttacacagtggcgagagtcc ctttcaccct[c/a]tccggcaaacaggccctggagcacaggcattgaacccagggggccgggtagatgacctgt/a/PR DM16/PR domain containing 16 40 724/2/rs4852814/71687044/[a/c]/caagacgggagctggtcaaatgtggcttcctctgattaggcttatcaga gtcctccatca[a/c]ccctaggacagtgaatcaggatgttctggtggcactttcagtctacaccccatctgccca/a/D YSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)" 725/5/rs2339745/172292640/[a/g]/tttgctgttgattgacaggggtgtccccaggaccccaacactcaaagt catggagaagac[a/g]ccaggccttagtgggcagcagagcatggtcagagtctgcagagtgggatgacccagcaat/g/ ERGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 726/15/rs2703593/55276059/[c/t]/gcttcctcatgtgttctctcttcctaataatgagcccctcagaaaatt ctgaatttgatc[c/t]attttttgtgtaaacctggaaccctgtgtttatcactttgttttacagtaaataagatga/c/ TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)" 727/15/rs2733310/55285983/[t/g]/atgaaaatagaagtttgccaacctgcactagatttaaagaaaaggtaa 50 (85) JP 2010-88432 A 2010.4.22 atgtagttccag[t/g]gaaaaacagacctaaagagttaaaaataaaattaaatacttcttagtcctgattcttggt/t/ TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)" 728/7/rs10808264/131837237/[c/t]/tgtggcatgggccatggtgtgtatggcaagtgtagtggagatgagag aggaaggatggtg[c/t]ggggaagaggaggagttccaggtctagagaggacaagagctgagcagaaaaagcaagcct/t /PLXNA4/plexin A4 729/8/rs7829427/135767133/[a/g]/cagaccaccaggtaagaggcagacagtcttttagcaaaacaacaccgg gagttactgtca[a/g]gcagaaagcacagaccttcatcaacgggagggcgacatatacgtgctaacatcaccctcc/g/ ZFAT1/ZFAT zinc finger 1 730/1/rs10915206/28721175/[t/g]/cctgtgaggaataaaagggttttgcatatggaagatacagtgagttag ccggtgccccca[g/t]gggctcatattttaggaagttgattggtatggtggacaggcatgtaaattaaagtgattg/t/ 10 RCC1/regulator of chromosome condensation 1 731/1/rs9426442/28774042/[g/a]/tgtcctctcatgtgatgccaactgtagtgaccttgtggggtgggctggg aaggacacagg[a/g]gctccatttcacagatgggaaactagtggctcggaaagcccaagtgatctgctgagggtc/g/T RSPAP1/tRNA selenocysteine associated protein 1 732/8/rs1352952/24406078/[t/c]/aaaaagtaatttgccttcttacagcactttgtcaaaatcagaatggctc ctgtccccaga[c/t]ctgttaatctctttttactgagaccgggagaagagggaaataagaaggaaatcttggtgt/t/A DAM7/ADAM metallopeptidase domain 7 733/13/rs9300398/96690316/[t/c]/cccatttcaaaagctctcccaagttactctgaaggttgattttgttag atacacatactc[t/c]tgggaagcttgttagaaggacagattccagggccccaccccagacttctgaatcctaggc/t/ MBNL2/muscleblind-like 2 (Drosophila) 20 734/15/rs3098183/48593761/[c/t]/aatctataaatctgtcctgccagaagtcagtggttttccagactcgaa ggcaggtacaag[c/t]acagttagggtgctggtaacattctgtttaaactctgttctgctggttacatgggtatgt/c/ USP50/ubiquitin specific peptidase 50 735/2/rs10497841/200410033/[a/c]/agagtgcagctttttcaagtatggctgggttcatccataactgctgg tcatggaagatta[a/c]gtttgtttatcccagttctcccatttggcctttccttcttcattagtacctctgttttac/a /LOC348751/hypothetical protein LOC348751 736/20/rs2268084/32095049/[t/c]/cttattcctgtgacttccttgctcatgaaacctctaaaatctaatctt cttagaatgata[t/c]ttgaggttctgcaaagacttttgcccttttctttccagtcctttctccaatcgtctcctc/t/ RALY/RNA binding protein 737/7/rs969708/107807080/[t/c]/catgataagcctcgactttgctaaatgaagtaagccactcacaaaaaga 30 caaatacctca[c/t]ttatgtgaggtacctagagtattcaaaattatagaggcagaaagtagaatggcgacagga/c/N RCAM/neuronal cell adhesion molecule 738/11/rs11222109/129841446/[g/a]/ccatttagagcttgaagactcccaaatttgcatcttcagtccaggc ctcgctcctgacct[a/g]cagacttgcttctctaagggaatctggacgtgtccattggacacctgattagcatcttat/ a/ADAMTS15/"ADAM metallopeptidase with thrombospondin type 1 motif, 15" 739/1/rs2281959/165364363/[g/t]/cggcgtctccaagcagcaatgatggcttcatcgtccatttcttcctct tcctccctgtca[g/t]tgcttctccgatactgggaccgccgtccagatgcaaacctcccttcttctctgttttctg/t/ DUSP27/dual specificity phosphatase 27 (putative) 740/2/rs6432765/164195266/[c/t]/tccccaacaccaggcaggtgcaaaccctggccaaaaggagggtcaagg tgaaaggcaatg[c/t]ggaaagatcaaggcaaactcatcaccaccatgagaaaatcaccacctgcaagccacagtg/t/ 40 FIGN/fidgetin 741/3/rs9310864/28425375/[c/t]/cagctcagttgttcacatagactgtcaatacctgctttagacttagaat tatctgaatct[c/t]ttttggtacagggaaagacatctgaaagaaaggaatacagagcccagaaatagattcata/c/Z CWPW2/"zinc finger, CW type with PWWP domain 2" 742/5/rs350477/83441800/[a/g]/ttttgctcctaaacagtaaagtaataagcaaatccaagccttagatttat ttcactctgc[a/g]aagttgtcacaacagcagattttcttcactaatcatgtggaccacaatcaaatggatgtc/a/ED IL3/EGF-like repeats and discoidin I-like domains 3 743/9/rs3935335/136735987/[c/t]/gtaaactctggcatgtttgctgtcggccactcataggcatttttcatg gattaattctca[c/t]ggtgcctcccacacacacaaaactgcggcgggtactattattgtcattttacagatgggg/t/ COL5A1/"collagen, type V, alpha 1" 50 (86) JP 2010-88432 A 2010.4.22 744/18/rs2957176/32483557/[t/c]/tcacagagccacagaaccactggttttgtagaaatacctgagcatgtt ttcattagagaa[c/t]tgcactttttattgaaatcctaccttcctaaccacactttatggaaaaaatcactggttt/c/ FHOD3/formin homology 2 domain containing 3 745/11/rs2136481/24596142/[t/c]/ataatgaggagttcccttttttccacagggtgtcagtggaggtctgct gggaaactggta[t/c]ctcttccactatctggcagtagtaataaggcattttctcttaccctgccagagtagtatc/c/ LUZP2/leucine zipper protein 2 746/7/rs10225212/121415911/[t/g]/ttcaggggtgtttatgtgcatgccttagtttcttagtagatccctgt ctaattgatctca[g/t]tgttacctgtaacatctgataaagtacctggcaggtagtaagagccctttgattccttga/g /PTPRZ1/"protein tyrosine phosphatase, receptor-type, Z polypeptide 1" 747/2/rs974736/80019524/[a/g]/attagattttaattgggttttaaagctaagatgaataggtagataaggta 10 gaattggtca[a/g]aaacatactaatgtaataaaacctttggttctctaaggctcttgcattaaagaccaggca/g/CT NNA2/"catenin (cadherin-associated protein), alpha 2" 748/2/rs2974140/80024455/[g/t]/atattatagattaattatggcagaattatcaattttggttactgttaat ttttggacact[t/g]tttaggatcttcccatgccttgtggcaaaggctatcatttgcttaaacaatgttcatttt/t/C TNNA2/"catenin (cadherin-associated protein), alpha 2" 749/3/rs352143/52239947/[g/a]/gggcctcgccttccccctgcagcctgaggcccagcgggcactccagcagc tcaagcagaa[g/a]atggtcaactacatccagatggtgggtgcctgctccctaccctggcacatgctgccacca/a/TW F2/"twinfilin, actin-binding protein, homolog 2 (Drosophila)" 750/9/rs10964139/19432558/[g/a]/aggctctacagagcctccctcctgcctcgtacatgccaagccggccct gtcctggcactt[a/g]cagtgactaacggccgggcacctccctctcggttgatgccctccatgcaggacatctcca/a/ 20 ASAH3L/N-acylsphingosine amidohydrolase 3-like 751/9/rs4466467/125202042/[a/g]/tcaaatccacattctgggcctgagctcccactcgggaagaaacgatgc tagcccaagagg[a/g]cctagaaatcaatgggtgctccaccgcgccccctgctgactggtgtctgacccacagcct/g/ DENND1A/DENN/MADD domain containing 1A 752/9/rs12341785/125208464/[t/c]/tcatctgtggggtgattgtgaagcccggatacagggaaagtcccccc aaggggtctggta[c/t]acaatgggggctcaataaatgctcatcctgctcctctgtgacctggatgtcccttcttgt/c /DENND1A/DENN/MADD domain containing 1A 753/14/rs11159273/77079605/[c/t]/gtaatctctggtaaaggcttggcttggatttaagttaacagttttag aggtagaaggcaa[t/c]acaataagacaatcagagttttacaaaacggttaatactaaacattttaacaactttata/t /SPTLC2/"serine palmitoyltransferase, long chain base subunit 2"/ 30 754/15/rs3743175/74483823/[c/t]/atacatctcaatatagaaagccaatgatggggaaagaacaaagaggaa agatggccaaga[t/c]gaccacttgaattcctatgaaatgaccctagaatgggcaaaattcaagagatgttccaaa/t/ SCAPER/S phase cyclin A-associated protein in the ER/ 755/18/rs7236448/6903534/[t/c]/tggttttaatgagacccaaatgactctctcttaacaattcaagcagtag acaaagttgct[c/t]acaaatacagaaaacatctttttgtctacttcgcaagtctcaaaacgtgataatatttaa/c/A RHGAP28/Rho GTPase activating protein 28/ 756/15/rs8038119/74701583/[c/a]/aggttcagaaaaatttgagatacttctctgcccctttctaactaggct ccggcttgccta[a/c]actagtaggtgacagtcatcaagctagtcactgatctaagacagttctcactatagcaat/a/ SCAPER/S phase cyclin A-associated protein in the ER/ 757/18/rs163064/22752805/[c/t]/tttttagtagtgcaagaggactgtgtgaataaccccctgaataccatat 40 gccaacgtgta[t/c]agccccgtgtatagccccgtgtattagtctgttctcatgctgataataaagacacacccg/t/C HST9/carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9/ 758/22/rs738993/30767340/[a/g]/gtctcatctttgatgctgatctatctctgtcattggtcaggaagctctg tgagggcaaga[g/a]ctctgtgtcttttcatagctgtattccagggtcggtacatatgatctggcacatagaagc/g/S LC5A1/solute carrier family 5 (sodium/"glucose cotransporter), member 1" 759/5/rs4090594/106984342/[c/t]/atattgtaattatttgcctgtatttttttcctttagcctgtaagttaa taggagggactt[c/t]tcaactctattttaccccatcctattttcttaattatgcatggtagggggcacttagttc/c/ EFNA5/ephrin-A5/ 760/8/rs17818622/25944469/[g/a]/aactttatcggtgaatgcagtgagatgtagttctttaaagtaagagct cctgcttagtgc[a/g]gagccattaaggtgtgtacttatgagaagcaaggtgcaggtgagtatttacagatttgca/a/ 50 (87) JP 2010-88432 A 2010.4.22 EBF2/early B-cell factor 2/ 761/7/rs6973312/101440565/[a/g]/tgattgggcctctctttcatatcaggcaacatacatgtgatgtacata cctgtagcttcc[g/a]ggaaagggaaggaagtagagatgacattgtctgttactcgtttgtatgtgtgtgtgcgta/g/ CUX1/cut-like homeobox 1/ 762/7/rs10486164/7458700/[g/a]/gtttcatgtgctcaattcatatatattgcctgaaatcccttcgggggat ggatttgcacc[a/g]gatttggaatatatatgtaaatgaaaaatgtacataatgtttgatgtatatatggtctga/a/C OL28A1/"collagen, type XXVIII, alpha 1"/ 763/7/rs13225983/6545106/[a/g]/aaagaaagagagaaagagagagagagagaagaaaggaaagaaaggaaat caaagggccaa[g/a]agcacacatggtttgtagggtggaggtcgagggggtactggagccccacatggcacagtc/a/G RID2IP/"glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein"/ 10 764/14/rs242401/55732814/[c/t]/accagatatcaaattatcagagactaaaagttttctgtggctcaaattg cttagtaaaca[t/c]agacttagaagggccttctccagaaataaatgccagacacactagtttcagggttcacaa/c/P ELI2/pellino homolog 2 (Drosophila)/ 765/13/rs7334198/101173858/[t/c]/tcatgtggttcaaaagcaacatagtcatactagtgtcaacttcaaag ctacacaaaataa[c/t]aacaaataactctcttcccataagccagagccttcaggagattatcatttcaatgttcat/c /FGF14/fibroblast growth factor 14/ 766/22/rs2235168/30979431/[a/c]/aactgcatgggacatagggacccatggagagagccgggaggctcctca gatgagaaaggg[c/a]tgaggtgaggcattgaaagaggacagcagacaaggggaggccaatcctaacaagagggcc/c/ SLC5A4/solute carrier family 5 (low affinity glucose cotransporter)/ 767/3/rs10804682/143717224/[a/g]/tgcttacctttttccagtatccttcttaggggtgaagtaggtcattc 20 ttggacacctaaa[a/g]tacttctaaggatttgagtctgccccctcctcttcctcagatccttccaactctattctt/g /ATR/ataxia telangiectasia and Rad3 related/ 768/10/rs686374/78837467/[t/c]/gtgccaagcttcagcttccccaccaccttaatgaggcggcatgtttgtc cccatcttaca[c/t]ggaagaggctgagactcaagggttgatgggccacagccatcagcttggaagttctggagc/t/K CNMA1/"potassium large conductance calcium-activated channel, subfamily M, alpha member 1"/ 769/6/rs9480684/107118918/[a/g]/ttattataatagtgttaggctaaaaatcacaagctgaaaggccgtgat tgcacttagttc[g/a]gtagagttgatgattctcatgtatacacgtgacctttcattgaaaagatctaagatctca/a/ AIM1/absent in melanoma 1/ 770/3/rs782437/128899892/[t/c]/aggggcctggctatctccttcctgggagccacaagccacattcctagga 30 cttttggtgga[c/t]tgagatcttaagctgtcaaaaaatcaaggccattgtgcttgtgccagaactgccacttga/t/M GLL/monoglyceride lipase/ 771/12/rs4882789/127628211/[g/a]/cagctctccgctccagccttgccctcctgaagtggctattgatcttt taaaagttttatg[a/g]tctcatcttggggtcacaaagagagcagtggcctttaactccccccagggcctgggatga/g /TMEM132C/transmembrane protein 132C/ 772/10/rs1968517/132938739/[c/t]/ttcctcggggttctaagtcagcgctaatcatttcaatagcatcagac cctccacagggaa[c/t]ggtggccggtatatcctacttggggaatctcattccacgaacgcagggaatcctgaggag/t /TCERG1L/transcription elongation regulator 1-like/ 773/12/rs2099014/14735102/[a/g]/ctaagtgagagaaattaaaatggcttgtacaagaacacataagaaatc actcataatgcc[g/a]gactgtggactgaggtttccagactccctctagacttggcaaacttaaga/a/GUCY2C/gua 40 nylate cyclase 2C (heat stable enterotoxin receptor)/ 774/2/rs3770244/45486604/[g/a]/gggttagaaggtctaagggaaagtaagataaaaggtggccacagcttct agcttttcgga[a/g]gtgaggaatagggagaccccagcaataatacatctttggccaaaaatgatgagaagaagt/a/S RBD1/S1 RNA binding domain 1/ 775/8/rs2977944/76637274/[a/g]/tagaaaaatatggcataatcttggatttccaatgtacttgaaagacatt atttgggaccatccttgcagaatagatcttaccattttcatttaacagataatcaatagcagaaagagagg[-/a/g]gc aagcctaataccaaactagagcgtttatggagttgtgtctcttaaagatcagttattcataaactcacaaaataaaacac attaacaacacaataaacattgtaggaatcaactgaca/g/HNF4G/"hepatocyte nuclear factor 4, gam ma" 776/8/rs1805100/76638951/[a/g]/gtgtttacttcagaacggcactacataaatgtgaaaagttgttgatctt 50 (88) JP 2010-88432 A 2010.4.22 gaaatatctca[a/g]gatagcacttttggcaaactcttagccaaggcttcttcattggtgctgttataagatggt/g/H NF4G/"hepatocyte nuclear factor 4, gamma"/ 777/10/rs667254/6604781/[a/g]/accaaatttggctgagcagatgtaattggaaaccattgaatgctttgttt ctcattccca[a/g]atttactattgattaatctgtgttctttcttccacatgtgagaggttttgatacaagtga/a/PR KCQ/"protein kinase C, theta"/ 778/10/rs500766/6590596/[t/c]/ttttcatatgagtttcaacagattaatgaaaagaaaagtgcttttgacat ggcatgtatg[c/t]accattgttctctggcttgtgaataaggagtaaagatggaggcaaaaatggagatggaag/t/PR KCQ/"protein kinase C, theta"/ 779/5/rs10515449/112268058/[t/c]/taaaaatttgtttcctgtacattcattctgggcagaggagatacgta attacatttcact[c/t]aaggtcttagttttgtgaacgcaatagctcacaactatgtacttccaaaagaagcaactc/t 10 /REEP5/receptor accessory protein 5/ 780/9/rs4240703/136735749/[a/g]/ttcaggaaaaagctttattttatctttaaaaaattaggatcctaaaac aaatagtgcttc[a/g]ttgatattctaactgagcaggaaaagctgttttcccaaaagcagatgtatgtgaagagtc/g/ COL5A1/"collagen, type V, alpha 1"/ 781/11/rs1792361/92083573/[t/c]/tgcgcaaggccgtgacagacccatgatgtgtgctttgatacatgcaca aaaccatttacc[c/t]gtcttcaaaaatgatgcttccagaagcaattcatttaaaagttcctgtcatgccacaagg/c/ FAT3/FAT tumor suppressor homolog 3 (Drosophila)/ 782/8/rs11783143/10072561/[a/g]/atcagaattgacttaaaaattgcatgtaggtatttgctacatgttttg gtgacatgatgt[a/g]taccattaaggaaatttaagatctttttgatcacaaagttctcagcttacatctggttat/a/ MSRA/methionine sulfoxide reductase A/ 20 783/20/rs6074640/13718745/[g/a]/tcagggcatggcaggaggaaaggcacagaggtagaatgctgtagggtg tgatatagtgat[g/a]tttaaggaagattaatctggggatggcattcgagaaagattgaagaagagaaagggtaga/g/ C20orf7/chromosome 20 open reading frame 7 784/18/rs1944545/73096412/[g/a]/cttcctttcattctttattcaaatcctacccactgtgctgtgctttca gacaacttattg[a/g]ggattcagcgtcactgatgatttacagaacatttttgcaaggtttgacaattaatgtccc/a/ GALR1/galanin receptor 1 785/2/rs711252/36545455/[t/g]/ccagaatcctccttctgatgggtggaatgatagttcctaacctaactttc tttactgcac[g/t]gtggatcttaagcaaacctttttgagtgcccttcagcaagcccctgaaggtaatccctgc/g/CR IM1/cysteine rich transmembrane BMP regulator 1 (chordin-like) 786/16/rs3115441/20898477/[c/t]/gagatccagtacagctttagttatagacatgaggatatgagaaggcac 30 atacactgactg[t/c]gacacgttagaatccaaactctctgaggacatgtcaacagagctgaggcagagaaggatg/t/ DNAH3/"dynein, axonemal, heavy chain 3" 787/15/rs4886417/73117212/[g/t]/ttaacaaagaaatggggggattctttgatctcattttgttcatcttct cttttgagcttg[t/g]ggtggtaggagggacctgaaccgaggctgggtgattcatctcctgtcctgggcaagttct/t/ PPCDC/phosphopantothenoylcysteine decarboxylase 788/15/rs3812945/73076775/[g/a]/gggacccagcacagagcacagtcaatccatatacttgcttaagacttg gacactttccca[a/g]tgggtgggagggaggcaattaacgccctcccccaatcagattaagcccaaagctgctgtc/a/ SCAMP5/secretory carrier membrane protein 5 789/11/rs2056903/8896725/[t/c]/atcaggtgtgcaggcagaggatgggtctcagttcaaatggtaaaaggac aaagtcacaaa[c/t]cagaagagagcctgtaattaagggccagagtgacacctgggatgccattacaagcttgct/c/C 40 11orf17/chromosome 11 open reading frame 17 790/9/rs10491577/118530295/[g/a]/cttgtctatgacctgagaactgtgggcggggcttgggtcttatttat tccagtatctcca[a/g]aactaacaaagattagcacgttgttggtgctcatgtatgatggaggaatttttaaaaata/a /ASTN2/astrotactin 2 791/2/rs11674078/234383263/[c/t]/gttattgtgcaactgtcactgccatctgtctccagaattcttcattt tacaaaaccaaaa[t/c]cctatatccattcaacaccaactctccattcccttctcctcccagccctggcaaccacct/t /LOC339766/hypothetical protein LOC339766 792/1/rs4657489/164122744/[c/t]/aacaatagagaggatgatataaccaaaccctatgtacatgtcagccag attcaacagtta[t/c]ccggattttttagggcccatttgtaatatggcccaggaggaagaaaatgcctgaacaatc/t/ UCK2/uridine-cytidine kinase 2 50 (89) JP 2010-88432 A 2010.4.22 793/17/rs915475/29314648/[t/c]/aagtacagtggcaggagccagcctgctttcttctcggttctgtccaatg catatttaagt[c/t]acttcccctctctgagcttcagttttctcatctgagtaatgaaagctcaagaacagatgc/c/A CCN1/"amiloride-sensitive cation channel 1, neuronal" 794/10/rs1904611/68693313/[t/c]/tggttgccatcatttgttacaagcacctattcattataaaaaaggaaa aacaactcatcc[c/t]tcaagaaaggatttaaagtgataccagaagacctcgatcttccactctccagcctccctg/c/ CTNNA3/"catenin (cadherin-associated protein), alpha 3" 795/6/rs294877/159526861/[a/g]/gattggctacccaaaagctattcccagcttctttctcccttgccttcta ctacagaggcc[a/g]gaatactaaacattcagtcatgacttttcagcttcccttgcagctaggatggccatatga/g/F NDC1/fibronectin type III domain containing 1 796/6/rs2295333/44076792/[g/a]/aagacccccaggcacaagcagcccaccttactgatggtcagagcatcca 10 gaagaagtggc[a/g]agacttcagctgtcctcaaagcaggaagacagagtgtttctggcagaaagaacagcacaa/a/C 6orf223/chromosome 6 open reading frame 223 797/20/rs6142828/59689160/[g/a]/ccctgtggattttcagagcttcggtagtcatggttcagcaagttcgat gctttcctggct[g/a]tttctgggatcgtggtagttggagcgttgactctgtagagaattccgtctccccgggatg/g/ CDH4/"cadherin 4, type 1, R-cadherin (retinal)" 798/17/rs6503235/9456502/[g/a]/cgtgtcagcttcacggatttcaaagagacgctcatagcgacttgtcact ttgatgctgtc[a/g]aggatattgtctttccattgtgagtagaagagaaaaacaagaatgtggagatttgatgca/g/W DR16/WD repeat domain 16 799/10/rs6586129/90127025/[t/c]/atacacacacatatacacacacacacacacacgcacacatccttattg ttattttcttct[c/t]atcttctaaatgtatttatttgactcccagtagaagacaactgtaagctacagggaaaaa/t/ 20 C10orf59/chromosome 10 open reading frame 59 800/5/rs2962038/1565868/[c/t]/ctgtctggactaagcgttccctgacaccctggctcacacccgtgatgcca gcacagggca[c/t]ggtgctcacacattggtgctgttggaaagtaaccagtaaaaaggtgtgtgaaagaaaaca/c/LP CAT1/lysophosphatidylcholine acyltransferase 1 801/4/rs1848038/16285484/[c/t]/ggtgcctggcacccagaaggcactgagtaaacttgttaatgtcattttt agagaaaaaat[t/c]aaagaaagaaaaatctaccgaaagcacacacacacacacacacatatacacagacacaca/c/L DB2/LIM domain binding 2 802/11/rs10892901/98582147/[t/c]/aactaatatgaatatacctaatttgggtttcctttgggattgtgcag gtagatttatttc[c/t]gaaagatttctttcttagtggaaagtgtgcctgggtaggaactttgtacaagtgggtgga/t /CNTN5/contactin 5 30 803/11/rs12293143/695404/[g/a]/ccactgcaccctggccctgttctgagcggtcacagcagctggggagaag ggccatcctgg[a/g]agccgggcagatgaggacggaaccagacagtcccactgtggtgggcagaggtggggcctg/g/E PS8L2/EPS8-like 2 804/5/rs254677/157188061/[g/a]/aaattcctttccttccatggccatagaagaagaagcctcataacacaaa agtatatgaac[a/g]ctaacaactatataaaaacacatgtacatgtgagcaaagcccggaagaaccaaaaaaacc/g/C LINT1/clathrin interactor 1 805/13/rs4614573/27454252/[g/a]/tgagcccaaagaccaatgcctgacctcttctttctcaacctctccaga ccatgtcacctg[g/a]ttggccctctctccttaaaaaatgactataaacggccgggcacagtgactcatgcctgta/g/ PRHOXNB/parahox cluster neighbor 806/4/rs2289319/154763717/[a/g]/ggtggacgcccagcacttcctgccggccggtgagtcctgagcagagcc 40 ccaggcactctc[a/g]gtggcccttccctctgccctcccacgtacccagtccacacagtctcgatctgccttcagg/a/ KIAA0922/KIAA0922 807/5/rs10069900/160850531/[g/a]/tctccaaataaccgtcaggttaatgccaattgagagatttgcttcct cactctagtatcc[a/g]attactgttctgggagggttcttaatgctatcacaatgccatcggtcccttccttgtttg/g /GABRB2/"gamma-aminobutyric acid (GABA) A receptor, beta 2" 808/8/rs1462977/99184535/[c/t]/attactccttctacacttcagcatatcattctgtgaattgaggggaaaa tacgtctctaa[c/t]agggcttctgtgagaatcacataagctaatatagtatatgaatatacctagcatggtaac/c/H RSP12/heat-responsive protein 12 809/1/rs6691415/77575717/[a/g]/tgcaagtttttatctgcattcaatgctgagttagaagttttttcttata ttttaatatgc[g/a]ttatctccaaaccaagcacaatatatcattttatttgtcaaaaaaatttcttatgtaatt/g/A 50 (90) JP 2010-88432 A 2010.4.22 K5/adenylate kinase 5 810/16/rs3812974/86253491/[a/g]/cggtgctaaaaaaaaaaaatcagacgcgagcctagtgaagtcaggcag aggggaaaatcc[a/g]gctgtccttttggttttggttttgggagatgcagaatgtgctgctgacagaaaccattca/g/ JPH3/junctophilin 3 811/6/rs443651/159554662/[t/g]/tgtttttagtccaaaagtatagtccagtaaaatgagcagatctactgag aacacacacac[g/t]ggtcttatgtgagtcagctggaacataaatcattgagcagagacagcatcctctgccctg/g/F NDC1/fibronectin type III domain containing 1 812/2/rs2869526/56288998/[c/t]/aatttctaattttatccatacaatgaagttttatccatacaatgaagca caatctcccac[c/t]attaccccattgcacacacatccagatatacacatcaaccgacattgactttggtaactc/t/C CDC85A/coiled-coil domain containing 85A 10 813/1/rs911271/234376647/[a/c]/tgcccttgggtacacatctgagggtaatgcgatcatgagcaagctcaat ttgattaactt[a/c]cccctaaatcactgcttttaaattctgccatgttaagtctctttccacccctaatgacct/c/G PR137B/G protein-coupled receptor 137B 814/7/rs6949736/48330883/[c/a]/tttcccaagaataagtagcatgcctgaaatgatacttcagtgagaatca ccaggcacatt[c/a]taggccactggtgcacaaagtaggtttagtctgggcttctaagggacgtataagcccatg/c/A BCA13/"ATP-binding cassette, sub-family A (ABC1), member 13" 815/13/rs677532/106994363/[g/t]/ttttatcatcaattctatataaccaattttttaaaaaatctacctgtg gagtaggggtga[t/g]gtttacagtcggaacaacaatctaaaagtcaaaacataatgtattttgatactcaaacat/t/ LOC728215/similar to transmembrane protein 28 816/3/rs8177191/134950829/[a/g]/actgggaagatgagtgatgcatgcagggggaagagtaaagtgtcctga 20 ttgcaggtgaca[a/g]ctgatctttttgttcttaggtctacaaaaatgctcttcattctttcaacgttgcccctgc/g/ TF/transferrin 817/1/rs12749/149822365/[t/c]/tgttttgaatttttctgattcctatagtaccatactctgatgcctatcta cttctcaagg[c/t]tgtaggaagagccctaaagaaaaacaccatgggccgggcgcagtagctcaagcctataat/c/TU FT1/tuftelin 1 818/14/rs1950410/26126092/[a/g]/taatgccagtaattgtcctgtagctttgaaatgtgttttctgaatttg tggtgcaattgt[a/g]gtaggtacttcattctcttgttttgttctactttttttttccctcccttctggatgtgac/g/ NOVA1/neuro-oncological ventral antigen 1 819/9/rs4430151/93702295/[g/a]/cagggctccagataagcctccctccagtgctgggcaggcccccagataa gctcaggatgc[g/a]gcgggtcccccagggccgccagggggtggggggcagggccccagcagcctcgcatccaga/a/R 30 OR2/receptor tyrosine kinase-like orphan receptor 2 820/3/rs13061174/86169562/[a/g]/ttattttaagtatttattgttaatatttaagaaattgcattctttact gatacaccttta[g/a]gcaaaaattaaagtagaatataccatataccagacatacacttccaaaaactattagaaa/a/ CADM2/cell adhesion molecule 2 821/8/rs2648896/129169615/[c/t]/tgccagaaaatattctgagtaagcagaacaagatccattactaaatca agcctcacccca[t/c]acctgggcagccccctcagcaagttaggtgccttgtttggcagaatggtggaggtcttcc/t/ PVT1/Pvt1 oncogene homolog 822/5/rs6879538/9464249/[t/c]/caccactccaaaaattgctgtcaacttccacacatactaagctagtggac ctaccccagg[c/t]aaaagaaacagggtcagatgctgcctaatagaaatcaagtgacacgtctttagcatgttc/t/SE MA5A/"sema domain, seven thrombospondin repeats (type 1 and type 1-like), transm 40 embrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A" 823/13/rs3903771/101371740/[c/t]/gaatgaagttgccatttcagaagtggcgaggattggaagaacaggtt taagaaggaagaa[t/c]agtagttcgttcatggccattttaagcatgagacacttacctatcagacatctttgtaga/c /FGF14/fibroblast growth factor 14 824/15/rs2053701/100022932/[a/g]/tgtggacttattcaagtctatgttgtggcggtttgaacttcctgaat ctgtaagttattg[a/g]tttgcaaacgttgtattgtttttccatatttctttggtactatacctccgctccttctgg/a /TARSL2/threonyl-tRNA synthetase-like 2 825/1/rs316274/176408831/[a/g]/ataattataaatggattttcacctatgtgcatgtgtggttggacgtttg tcactttgtgg[a/g]aatatccatgcattccattctaacatacgtgtccatttctccatcccttcctccccagtg/a/R ASAL2/RAS protein activator like 2 50 (91) JP 2010-88432 A 2010.4.22 826/6/rs9394866/42182084/[g/a]/ctgccgccaagactcttttcaggaacacctgggggagtgtcctttgctg gcaggctcagg[a/g]gagtctccttctcaggcaggcgggggcccttcttgccctccttgctctgaggggccactg/g/L OC100128918/hypothetical protein LOC100128918 827/12/rs2243396/112017507/[c/t]/cagatgcttctccaccctgccaccacctgttcatggtctaaatccct gtactgtccctct[c/t]tgcagggccctgagcaccccaaccccgggaagaagttcaccgcaagaggattccctcgcc/t /DTX1/deltex homolog 1 (Drosophila) 828/1/rs4147592/163866770/[g/a]/cacgcgccttgcatgcccgtgcttcgcccttacagcagagcgcctaaa accgctacggtg[a/g]ctctgctggggacaaattattcacgtcccactgttctgcaaacccaatccgggaggtatg/a/ MGST3/microsomal glutathione S-transferase 3 829/18/rs2644267/32490024/[a/g]/ttagctgctggagtaggatgacaagctgagcatccaggcagctgctga 10 cacaggcatgga[g/a]cctgtgtggatcaggctgcatcagggtctcgtcacggagagtgctaggtgtcgtgcgggg/g/ FHOD3/formin homology 2 domain containing 3 830/2/rs10932398/212335504/[g/a]/aagaaggcaggaaatatttccaggtatgtttcagaaagggaaacaga aacccatggatgg[a/g]gcaatggtggattagtgaagaagattagatgtcactgatgtgggggtctcagcccactcc/g /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 831/19/rs2056822/15600597/[a/c]/ccccatcagcagccttaacttgcctccaccccaggtctatgacccctt ccgcttcgaccc[a/c]gaaaacgcccagaagaggtcacctatggcttttattcctttctcggcggggcccaggtga/a/ CYP4F8/"cytochrome P450, family 4, subfamily F, polypeptide 8"/ 832/3/rs1045482/48287233/[g/a]/ggggagagatgttcatgtaacctcaaaatacttaggcttggttttgatg ctagagaggaa[a/g]aaggacttggagagagagaaggaatggctggtccagaggcttttgtccactccctctcac/g/Z 20 NF589/zinc finger protein 589/ 833/7/rs2700991/37347745/[g/t]/tcaatgcgagagttatatggaattgtgcgaatccaaaggaatcattaaa atgaattatac[g/t]ggtcagctcagaattaattgaacttaaactcaaatgtaagaaagggtaaatttttgggat/g/E LMO1/engulfment and cell motility 1/ 834/6/rs583759/167088880/[c/t]/ttgtgtaggtaaacacatctctttctgttccgagccctgtaagaaacat ctcctgctggt[t/c]ctcctggagagttcaccgtataaaggagtgaacaccctgaacagaatgcatctaggaggc/c/R PS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2"/ 835/1/rs11121384/9336233/[t/c]/tgcagaggggacacctcagctctgtaatggctttgcagacactggacac aaggagtcctg[c/t]cctgctctgaagagatgaccgtgcccctgagatcagaaccctctgtctatggctgggcgc/c/S PSB1/splA/ryanodine receptor domain and SOCS box containing 1 30 836/3/rs2291977/56949779/[g/a]/atataactagggttcctttattcctgagatgactgttttctaaagataa gtatttaacag[g/a]tgcttttttttttaaatgtgagctgccccctcataaaggcaaaaccgaccatacctgggt/a/L OC100128209/similar to hCG1799667/ 837/3/rs3890747/56961527/[c/a]/ggatcttgggcagagaactcacttacacc[a/c]tgccctaacttctaa tccacagaactccaagctagtgaacaactgctgtttaagctgcta/a/LOC100128209/similar to hCG17996 67/ 838/3/rs4626067/56968071/[t/c]/agtcactgctttcaaatgcaggtttatcaaaaagagagatgcctcaaga aatggcccaaa[t/c]aaggtggatggagttttcaacagctctgcaatcttcagcagccaaattcaccccaaactc/c/L OC100128209/similar to hCG1799667/ 839/6/rs9379638/10744123/[g/a]/ccagtctggcttcctctgacctcccaatctggacattgtctctatgggc 40 ctgttgtctgc[g/a]tttatcttacctggaaactctcttccttgttatgatgttgaatcttacattccatagaat/a/G CNT6/glucosaminyl (N-acetyl) transferase 6/ 840/4/rs12507314/26348862/[c/t]/ttaaaaattaagtcatgtagaatcttttttacatataatctataatgg actaaagctttt[c/t]catttcatagctatataaaggaattcaacataaacaactgtggtatcttgaataaaaact/c/ TBC1D19/"TBC1 domain family, member 19"/ 841/11/rs7114881/129228935/[g/a]/ctgactctgtgtgtgggaattcaaaaagggtctggcttgagaaacaa gtatctgggaaac[g/a]gagtccaaaatgtcatcatggaggatttcttctaggcttccccaagaacactttgggtac/a /TMEM45B/transmembrane protein 45B/ 842/14/rs12588192/46651013/[g/t]/atgctcttactgtctgcccaggctaactctttatcatgaacctgtaa tatgaacaacaaa[g/t]gggctaagttgaaaggactgagatgaggaacctggaatgcagaacaatggcaaagtttat/g 50 (92) JP 2010-88432 A 2010.4.22 /MDGA2/MAM domain containing glycosylphosphatidylinositol anchor 2/ 843/14/rs12894609/94837133/[c/t]/ttttagaaaatagaaataaaagttgcagattctgcacctgatgcact aagtaattttcca[t/c]gaagtaactttccaaaagggtcatgcactattgtgtcactttgttggattcttcccacaa/c /CLMN/"calmin (calponin-like, transmembrane)"/ 844/3/rs3804766/51405697/[c/a]/ctgggaagagaggcggaaacggagaagcctttccagtgaccgtgggagg acaacccattc[a/c]ccatatgaggaacggagtaggaccaagggcagtgggcagcagtcagagcggggctccgac/c/R BM15B/RNA binding motif protein 15B/ 845/3/rs2241785/51393175/[a/g]/tgacataaaggctgggtcatcaggcctgttgaggaggggcagaaagaac cctggtgggcc[a/g]tggaccagaggaatgtattctgctgctaaaatctgtgatagactcagtcttttccaattt/a/D OCK3/dedicator of cytokinesis 3/ 10 846/3/rs3828395/51386837/[c/t]/cattcctcctgtgcttgctgagttcatcctcaccctaactg[t/c]aag ggacacctaccctggttccctagtcctgaggatgcttgactgctggaccctccatct/c/DOCK3/dedicator of c ytokinesis 3/ 847/5/rs246391/149477370/[c/t]/acacacacacacacacacacacacactgtgcacaatttccttggcccca ggccagggtgg[t/c]tacctggctaggctgggggaaccctccagtgggccctcgtcagcaacctcgggtttgggg/t/P DGFRB/"platelet-derived growth factor receptor, beta polypeptide" 848/5/rs246395/149479865/[c/t]/ccacacgtcgctcagggtggtgtagaggctgttgaagatgctctccgga gccatccactt[t/c]aaaggcaaaaaggtctgtagggaggtcaggacaggtgctgagtgcaaggaaggacctcag/t/P DGFRB/"platelet-derived growth factor receptor, beta polypeptide" 849/14/rs12589992/29457271/[t/c]/atgctggggagggagaaagaatcttgtaggatcacctgcagtgttac 20 aaagggaactcaa[c/t]gtgagacaggtaattcaaacagtcagaactatgaaaatatcaaatagtaatttacaaaaa/c /PRKD1/protein kinase D1 850/14/rs178205/26027844/[a/g]/tcaagtgccatttttctcatagcaaaaatttaaaagtacaaattactgt caaaaatggtg[a/g]tattgagggggagtggagacaagtcagcaaatctctatttattatgtacatataaaatgt/g/N OVA1/neuro-oncological ventral antigen 1 851/21/rs1109850/34151763/[a/c]/gcagtttggagagtgctgtggtagtctggcaaccaccacaccaaacgg gtgtgaaaccat[a/c]ttgtctgatagtcttaacatccaggaaagacgcagcagggctcgccgctgttggaggagt/a/ ITSN1/intersectin 1 (SH3 domain protein) 852/2/rs13419826/133945478/[c/t]/aacaggtggagagagatctggagcccatcctaggaaaaagcaaatga catttctctcttg[c/t]gacccagtcattgcaaatttggtctgtctttgcaaggaacctagtgctagagccattgct/c 30 /NAP5/Nck-associated protein 5 853/9/rs3780381/5104523/[c/a]/cgaccaagatcagcggcccatgtgctcccccacaggtctacgtgtttgca acgctagaag[a/c]gccgaggaaccaggacaagcgcaccctcacctgcctgatccagaacttctggcccaagga/c/IG HEP2/immunoglobulin heavy constant epsilon P2 854/15/rs11632698/72424920/[g/a]/aacaaaactccaactcccctccactccctctgctgagggccaggaac tgatattcttaga[a/g]ccctttgtgtaactttcagtctctccagtctttgcctcagctgcaggcatgccttccatg/g /CYP11A1/"cytochrome P450, family 11, subfamily A, polypeptide 1" 855/14/rs17109462/24536305/[a/c]/accatttccccaacaacaacactcacatacgcaggtgctcatgaact gaagccaagtcaa[c/a]cttcttgtacttccaaaactcaaacctgacaccatcatccaggcctttactctctcatgc/c /STXBP6/syntaxin binding protein 6 (amisyn) 40 856/1/rs834482/64253865/[a/g]/attgactggcctatagcttagagcttgatgcttagctagtcagaatgggg tgactgagtc[a/g]ttttcttgtgctttaattgtatatatttggagctatgggttgaaggtggtattgtaagga/g/RO R1/receptor tyrosine kinase-like orphan receptor 1 857/1/rs834485/64257073/[t/c]/aacatctagtgcagttgtttgaataaagagagaaatgaatgagtggtgaa aatcagaata[c/t]gggagccgaaagttactttagagtagctgtcctcaagctttggtgggtgttagagtcact/c/RO R1/receptor tyrosine kinase-like orphan receptor 1 858/1/rs1260836/64261444/[a/g]/cagacttttgtgctggatcgcaggtaaaccctgggtagaccttgagata ctgcccttgca[a/g]tggtgctgagtaacagaaggatgctagcatcctgcatcgagtcagaggagctcactgtag/g/R OR1/receptor tyrosine kinase-like orphan receptor 1 859/9/rs602060/134990266/[a/g]/tctatgggacaaacaacccagtttcttcaacaaatacatttcagaggaa 50 (93) JP 2010-88432 A 2010.4.22 aaagaaagggg[a/g]aactagactaaaagaagggtcagagacgtctaacaaatgcaatgtgtggattttggatca/g/R ALGDS/ral guanine nucleotide dissociation stimulator 860/12/rs4768560/43256238/[g/a]/tccgcttcctttagatctcaattcaaaccaatgacctcagtaaagcat tcaggcatccct[g/a]agtagatcaaatcccccatcccactccccacgcacaacgtggatggccactttcgtagtt/a/ NELL2/NEL-like 2 (chicken) 861/19/rs4830/44889764/[g/a]/tgccatcttcaaagggtaaatagtagcatttctcctcatatctccatatgc caaacacac[a/g]actgttcatgattgcaggatgaccaaagtgcagtcggaattggaaagcaatatctgagtc/a/LGA LS14/"lectin, galactoside-binding, soluble, 14" 862/22/rs133074/39408419/[t/c]/agctggtggataatgaaaaataaagcatcccatctctcggcgttccagc atcctgtcaat[t/c]tcccttttgctctagaggatgcatgtttatttgaggggatgtggcactgagcccacagga/t/M 10 CHR1/melanin-concentrating hormone receptor 1 863/12/rs1861918/31002885/[t/c]/tgttcagacctggtctcccagtcctctccctgagcccccatgctgtgt ttgctccccaaa[c/t]tagacccattcacttctccgtcatagcagaagtcactctggtggttactaagtcaggtct/t/ TSPAN11/tetraspanin 11 864/6/rs1893119/162956501/[c/a]/tcagagaccttctgtgctccttccagtcactctgcatctgtgagtgcc tgccaagggtgt[a/c]cataggtctgtgtgcaggtctaaaaaaaaaatccatctcatggaaattgaggaagttaaa/c/ PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 865/13/rs655653/97735072/[c/t]/cagaggatctcagtctgcctcagagtaatttgagtgaagtgttggatta aaaccaggctc[c/t]ggaatcgttcttcctgtgccagctgctagctattgactctccttgagctgaggcacactt/c/F ARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived 20 )" 866/13/rs1965154/23970200/[t/c]/gcctgagctaagacaacaggtaagaagaaaaaggttgggaggtcggct gattcattgaaa[c/t]gagttatgaacagaggtcagtaaacacataggaatcaatataaacagcattacctccatg/c/ PARP4/"poly (ADP-ribose) polymerase family, member 4" 867/12/rs169305/97733124/[c/t]/catctagacatttctcagggagttttgcttaaagaagattagagtaatt gagcaggaaac[c/t]gagggtgatgttggggcaagggaaggagtttgtttgcttttgatggaagatgttatagca/c/A NKS1B/ankyrin repeat and sterile alpha motif domain containing 1B 868/20/rs2268086/32112399/[a/g]/gcacatggaagattgaaggtgcactaattgtgcctttgagcactggtt aagagctactca[a/g]tttgcccagtcatagtcttaggtaagtacagtagcattcaggaatgaatctggtgtccat/a/ RALY/RNA binding protein 30 869/8/rs9644681/10031914/[g/a]/gtcaaacacctctctagtcattgtcgtcatgggcccaaaaagactgtta gcctctttacc[a/g]tatagatagatcaaatatatatttttgtcgaattctgcagtaacctgtgatgtgcgttgg/g/M SRA/methionine sulfoxide reductase A 870/13/rs10870946/59346186/[c/t]/gaagaagtaaagttgtttcgtttttgtcgtggctttggtgttggtta attttcatttttt[c/t]atgtttgcttttggttccagatcaccagtcagggattttccattctgggatatgaaagta/t /DIAPH3/diaphanous homolog 3 (Drosophila) 871/15/rs745032/38889959/[c/t]/aatcaagtaggtctggccgtccccaacaggactgaggggccactttttc ctgccctaccc[c/t]atcgtgctgtttgtccctggtccccgggtctggtagcaggcctgaggatcaggaggtagg/t/Z FYVE19/"zinc finger, FYVE domain containing 19" 872/8/rs10957146/61657532/[a/g]/agagagggtctaattgttattttccacataggagaagttattttcatt 40 gaatctcagcac[g/a]ttaggatttacagatgtccactcagctatgtgggatggagtactgattattttacgcata/g/ RAB2A/"RAB2A, member RAS oncogene family" 873/8/rs603239/61684483/[t/c]/catgtcttccttctgccaccagccaccacacacaacatctgaattgatag acttcttctt[c/t]tccttattcctgtgttgtcctgggcatgaattcaccttagtatgatatcattgcacttgt/c/RA B2A/"RAB2A, member RAS oncogene family" 874/21/rs2839384/42126179/[a/g]/tcaggaacccacaggggcactgggtcccaacaatgcttctccctccaa taaccctgcgcc[g/a]aggggatctaggtttatgtctgaataaatgagccactgagaacagctgcctactggggtc/g/ PRDM15/PR domain containing 15 875/2/rs1529409/71684197/[t/c]/cacttcctgccattagggaatccccagaccgacagcggacactatttga cattttcagtg[c/t]aatttggacttgaagtgcagagtcaggatgtgg/t/DYSF/"dysferlin, limb girdle 50 (94) JP 2010-88432 A 2010.4.22 muscular dystrophy 2B (autosomal recessive)" 876/7/rs2244480/50706457/[a/g]/aaacctcacattatcttcactcggcatttccaatccctccccatgttta aacatacctca[a/g]aaacccccatcataggctgtgtcctcaagtaatttttttgacaatttttacgatttcaca/g/G RB10/growth factor receptor-bound protein 10 877/10/rs6480281/69061112/[c/a]/tctctgtgcccaagagaaaaaaaaaatacattaaagataaatcaggtt tggtagggaaga[a/c]tttggtaaccataaaagagcagaataaagatttatgaagaaatgaattcagaagttagag/a/ CTNNA3/"catenin (cadherin-associated protein), alpha 3" 878/10/rs1996316/17173689/[a/g]/aaataatcttttcaggagatacatgaaatctgcttttctattatgaag ttaacattggtc[g/a]gagtgttctgatctcctcaggttgaacttcccattaaaagcctcttttgcactttctcta/g/ CUBN/cubilin (intrinsic factor-cobalamin receptor) 10 879/14/rs3742810/73547241/[t/g]/ggaggtaatggtggtttattgaaggagctgggcacatgacagtactga tcagtgaaaata[g/t]atagcatgatgtcagaaaaaactagctcaaaaaggatagcaatctgggaccatttggtga/g/ ENTPD5/ectonucleoside triphosphate diphosphohydrolase 5 880/14/rs4636823/55680438/[c/a]/aagtcaggatctgggtgctaattgaactcattgctactggattatcat tgcttccagact[a/c]tcttggtggagagctaggaaaaacatgcatgtatactagcatatgcttgtatatacatct/a/ PELI2/pellino homolog 2 (Drosophila) 881/1/rs2236832/18872418/[c/t]/aaaatgtgttcacttaaggagctgaccgtgtgggattgggcttcttagt tctgaagagca[c/t]gtggtcttctccatggggataaaacagtggtaacgggtgtctatgacgctcttgccttat/t/P AX7/paired box 7 882/3/rs1379656/28502629/[c/t]/gtactattcctgaaacaggataattatttgtaagtgggatttgaattag 20 ttgtaaatgta[t/c]attgcaaactctagggcaaccaccaaaaagtttttaaaaaagtataactgataattggta/c/Z CWPW2/"zinc finger, CW type with PWWP domain 2" 883/6/rs9341963/84343957/[t/c]/ttcatgtgaaaaagcaaaagaaagcagaagtgtaccttacatatgtata catgaatccct[t/c]gtcaaatttcatggcagacgggaatgagttacctgagggcctgggcctctgttgcaagct/t/S NAP91/"synaptosomal-associated protein, 91kDa homolog (mouse)" 884/8/rs270/19857956/[a/c]/ataaggaaaccaaggagtcctatttcatcatgctcactgcatcacatgtactg attctgt[a/c]cattggaacagagatgatgactggtgttactaaaccctgagccctggtgtttctgttgat/a/LPL/l ipoprotein lipase 885/18/rs7242486/54202587/[g/a]/tttcactctcaagttgaaagcttgttatgctgaatacatagactagaa ataaggtacctc[a/g]gttcttacctggccacattaattggcactctcgttctgaatatgaacaatcttagctgat/a/ 30 NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" 886/13/rs7400267/113632689/[t/g]/cagcagctgataccattgcttgtcgcagacccagctacaccacaggt tcagactctcatc[g/t]tgctgggagatgacatattgaagctaaagatcccctttccctccctcacatctccacccc/t /FAM70B/family with sequence similarity 70 887/10/rs10740006/61501750/[g/a]/aaatgccgactgttcacaaaaaccatcgggaatattagaagacagca ttctcctctcatc[a/g]gcaactctgacgggaatgtgtgacactgctgagctctcgctcctcctggaaggctgatca/g /ANK3/ankyrin 3 888/10/rs10821668/61501277/[c/t]/gaaggaggttgcttttgctgtctagttgtataaaaggtccccctggt ttcttgtactgtc[t/c]tacattcctgacttatgattttttttacacctccttgttgtatctccttttcatattgct/c /ANK3/ankyrin 3 40 889/4/rs8732/83570845/[g/a]/gtcctgctcacgagttcagggctcctgggcggccgccttttccagttccagg tgtgcaga[a/g]gtgtcctctccccacgcgcggcgKgctgcacttggtcgctggctccgagatcgcgcgggg/g/ENOP H1/enolase-phosphatase 1 890/4/rs997721/83564316/[c/t]/aatccttgagttgtaactacttccaatgctcttaaaccatagctcctacc agttttacag[c/t]gctccttttgtatctgaacttttatcaagaattactcattgtgttatgattaca/c/HNRPDL/h eterogeneous nuclear ribonucleoprotein D-like 891/1/rs11247814/28614909/[c/t]/tgcaaaggctttattcatatgcatggcattctggaaacaaatttataa gataatacctcc[c/t]tttgattagaatttgtatcatataggaaataggagaagtagtttgttaaggtagcaaata/c/ PHACTR4/phosphatase and actin regulator 4 892/1/rs7518249/28611931/[t/c]/ttttcctgaggttcctagaggcccttctatggaagtcatgagtaaagtt 50 (95) JP 2010-88432 A 2010.4.22 aagatttaatc[c/t]tggagattgtattgggcagggtttcagtgtggactaggtcttggacatttgacagaaata/t/P HACTR4/phosphatase and actin regulator 4 893/1/rs7518232/28611885/[t/c]/aaggatctcagggatccccagagatcagcagattatacttgcttcattt tcctgaggttc[c/t]tagaggcccttctatggaagtcatgagtaaagttaagatttaatcctggagattgtattg/t/P HACTR4/phosphatase and actin regulator 4 894/20/rs6034006/1467511/[g/t]/cagttgagtcatccccaggtgagtttcccaactgagaccccaggcaaca tatagcagaga[t/g]aagtcattcttgtaccctgtctgaattccttacccacagtgtcattgatcataataagat/t/S IRPD/signal-regulatory protein delta 895/1/rs4661543/15101688/[t/g]/aaatcttccatggtgtttccaaggggaggctaatattcagctagagcca gaaaaatacag[t/g]tccttttaccagctttacagacattttggaaagtggcatcattaagtccatgtgaataca/g/R 10 P1-21O18.1/kazrin/ 896/11/rs1396850/24509909/[c/t]/gacttctaagtttttgtcttaagctaatgtgtatatgtcactataatt tactgaaatggc[c/t]gcatattttggccatgataattttgaaatttctcttgggcatccaagttgagatgttaag/t/ LUZP2/leucine zipper protein 2/ 897/9/rs10992158/93714748/[c/t]/ctttcttccaaagtcaaagcaaaaatctccatatttaaaagaatgtga agcttaagtgtt[t/c]tgggaaaaaaattaacaaacatgtaacaggaaaaatctggaatatttctgatttatcagc/t/ ROR2/receptor tyrosine kinase-like orphan receptor 2/ 898/6/rs394563/149838707/[a/c]/atttaaaaaaattttttttgaaatatatcggtctttgtgggtagaaaag agagagggacc[a/c]aggctgtctagagtgttcctgttggtttcatcatcatcatttagaagccatctatcagga/c/Z C3H12D/zinc finger CCCH-type containing 12D/ 20 899/6/rs369643/149841491/[a/g]/gttctgtactggggccctgggagaaggagggcatgtctataggtcacct acatggtgtca[a/g]ctatgtggaaatacctgttggaacagctctagatttaagaattaactttttagtttcaga/g/Z C3H12D/zinc finger CCCH-type containing 12D/ 900/8/rs6984344/124777648/[a/g]/tgtttagcaggtggaatactgtacctatcattccttgacttagttttt ctctcaataata[g/a]tatcccggagatccagctatgcttgtacatggatagtcacctagagttttttaaagggac/g/ ANXA13/annexin A13/ 901/16/rs9937979/10057711/[c/t]/ccacccttgatccattcaaccctacatctttccactcatccattcaaa taatcattcacc[c/t]ttctctttatacaacaactcctttaccaatccatcctcttccccttccagccaggctggt/t/ GRIN2A/"glutamate receptor, ionotropic, N-methyl D-aspartate 2A"/ 902/18/rs628229/4239393/[c/t]/ttttttgccagaacattcaaccatgtcaggccattaacttgctgggatcc 30 ttagtactct[t/c]gtgtagccaggtgcactcttgctctttttcacatctagtctctttattttaaaaaacaaa/c/LO C388458/hypothetical gene supported by BC040718/ 903/21/rs2836489/38832550/[t/c]/ggccaaacatgactggccagcaggctgggggacagaagacatgtgggc ttgtgcttgtta[c/t]ctggaattgaaaagagctcttggcatggttcttgttcaagctccatggttgactagcaca/c/ ERG/v-ets erythroblastosis virus E26 oncogene homolog (avian)/ 904/6/rs1320315/71722867/[a/g]/ctgtccaagctgcgcactggggtccctcggctcgcccctctctggggtg tccgagaggcc[a/g]gggagcgtgcaccatgaagtccgcgcttttcacccgcttctttatcctcctgccctggat/g/B 3GAT2/"beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)"/ 905/13/rs9300698/101286288/[t/c]/cagcaatggggtctgactgttgctggaagaaatctaaaggctacagg ctgcctggaagta[c/t]aatgcaaaagagagagagggctgtgttgggagccagttgtacttttaaaaatggggggtt/c 40 /FGF14/fibroblast growth factor 14/ 906/11/rs4937787/132880858/[c/a]/tgaggtgaactgatgcctcccaaaaggaagagaacaaagtttttctc ttgcctccttaga[a/c]agaggacatgaattataactatcaccgcttccttcctctctgcctccatgaaggccacat/a /OPCML/opioid binding protein/cell adhesion molecule-like 907/2/rs7597183/79680782/[a/g]/ttcctacgcataggaagagaataatagcagtaagatctggaccctaaat tgaactacacc[g/a]agagatagtgagctccttgccccttagttattttattttatttttgagactatgtcttcc/g/C TNNA2/"catenin (cadherin-associated protein), alpha 2"/ 908/14/rs3742553/80860799/[a/g]/ttagagaaacaggattctcaacagtctcccagtgcctatggactttgc cttgtccaaggg[g/a]cacattcttgaagtaggcatctagaaatcaagattttagaaatggattcacattgaaagt/a/ STON2/stonin 2/ 50 (96) JP 2010-88432 A 2010.4.22 909/15/rs4777074/66687334/[g/t]/agaccaggactccaggaacagatgccatgtgacaagaccccagggcct ttatcatcttct[t/g]gtcaaaatcacatgcccttgggcatagcacctcatgaaacagggccttgggagtgaatgg/g/ CORO2B/coronin/ 910/10/rs7358069/30007652/[c/t]/aggaattctgttcagtataatgcaggtaactagcctgagtaagaagaa tcaacaagcttt[t/c]gtccaaaatgaaattagtgagcagagtagaagctggaagatgtgtgggggatattaaaac/c/ SVIL/supervillin/ 911/8/rs4531010/10418538/[g/t]/gctggacagtgaatgagtatttcacaagaatagacctaagtcatgttct tgggagggatg[t/g]agactctacagtgtggtcttcagcaggaaatcaatctttctggaggtgatggatgatttt/t/L OC346702/similar to hCG1643218/ 912/18/rs11564339/23985498/[c/a]/gagccaaggttaagaaaacctgttctacagcaacacatgaaaaagag 10 gtatctacctacc[c/a]attaacactgctatcggtatgaggatcactgtctgctcaagtagcctcatcactcttgga/a /CDH2/cadherin 2/ 913/18/rs8086848/54212303/[a/g]/cagcccatgcatcttccacgtgaggacgctgaagccctgtgaggacaa tgagctccttaa[a/g]gtcacccagctcattagtgcagagcaaagccaggtccgtgtgtcctgacctctgaaatga/g/ NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like"/ 914/5/rs10512779/5334408/[a/g]/gttacataagctccaggcctcacaaaacctccaggatccactcagataa tagataatagc[a/g]cttatgatgatgataaaaggtttttaaaacttttgtattaaaacatgtattttaacactt/a/A DAMTS16/"ADAM metallopeptidase with thrombospondin type 1 motif, 16"/ 915/7/rs3801263/97802952/[c/t]/gcatctgccggagaggagtcccagcgggggagctggcagcagttaccac ccctgtgccac[c/t]gctgcctgcctcagttataaatttctggtgaggcaaggatgtgagaatcggatatagtta/c/B 20 AIAP2L1/BAI1-associated protein 2-like 1/ 916/7/rs6945554/97810882/[c/t]/aggacttgagtatcccatgctactgtggttgttaggattatgtcgttaa tgcaccttaaa[t/c]ccagacacttagctagctggtagtaaagaagtgctttttctttggagaaaaggataccaa/c/B AIAP2L1/BAI1-associated protein 2-like 1/ 917/7/rs6961129/97813478/[g/t]/tgcagatttcagaaaagaactaaataggacttccagtaacgaaagacag gcactaaacaa[t/g]tcaatggaaccagcagttaggaaataaaaatttaaaaataccatttacaataggacaaaa/g/B AIAP2L1/BAI1-associated protein 2-like 1/ 918/8/rs2726943/27873403/[a/g]/tgcacatgtttccaataaacacacagggaagcctggagacattgttgga gaggtccttga[a/g]gtaccgtgacagcgcagggctcagtaagccaagaaacaggaacagaacagcatttccagg/a/S CARA5/"scavenger receptor class A, member 5 (putative)"/ 30 919/9/rs2487052/106726226/[t/c]/acgtgaaaaacatttcaaacagtacttgccacacagtgctatataagt gtctattcaaca[c/t]tgcaataactttggccattcatggttgtatccacatgcagatacgaagatggttgcattt/t/ ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 920/21/rs3788111/44492599/[t/g]/ctggaaaggctgttgaggggcgggggcagctgggagaggctgtggggg cagcagaagggg[g/t]tgcttagccgcagagagggcacgtggggaaaggccatgtgttcaaggccccaaaaggtgg/g/ DNMT3L/DNA (cytosine-5-)-methyltransferase 3-like/ 921/19/rs16030/13248904/[c/t]/ctcttgcttttatcccttacaggtgctgcgatactttgactacgttttta caggcgtctt[c/t]acctttgagatggtgatcaaggtgagtgcagattataagtgagaacacacggtaattttt/c/CA CNA1A/"calcium channel, voltage-dependent, P"/"Q type, alpha 1A subunit" 922/7/rs732855/7877896/[a/g]/tgggttgaggctcaaatgggtaaagcaacccccttcaggtcagatggcagt 40 tttatcagg[a/g]taacttgaatgagaaagcatgtcccaatttttttactgtactagatatagtttgatacat/a/LOC 729852/hypothetical protein LOC729852/ 923/21/rs2186290/35141586/[t/g]/ttctctttaatttcttctcaccaatcctgaaagacacgacgagataat atctactttcaa[g/t]aaatcaattaattttatttaaaatccctaagattttaatatagtacatgcaaaacaataa/t/ RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncoge ne)/ 924/4/rs12650438/91747135/[a/g]/ttccacaccaaatagttatcttttaaaaacataacattacagatacat tttggcctgaag[a/g]tattttcataagttccctatttatatgttgttgatgaaattaaggattccagtaaatcat/a/ MGC48628/similar to KIAA1680 protein/ 925/6/rs10485060/154557793/[a/c]/tacttcacaaaacaagattactaggtaatgttctaggaacaaaatta 50 (97) JP 2010-88432 A 2010.4.22 agtgctgaggata[c/a]aaaggccaagatcagtcttcaccctgataggcatgctgcagaacccctcatctccccttc/a /PIP3-E/phosphoinositide-binding protein PIP3-E/ 926/2/rs6430516/134935075/[g/a]/gggactagggaccgagtcagtggccacctgccactttgctccaaatgt cagggccttccc[a/g]atccgtcattccacatgaagagccctgagcccccagcccagcaggcaggccctgccgtca/a/ TMEM163/transmembrane protein 163/ 927/4/rs955999/91753475/[c/t]/aaacagcactcaagtcaggcaaaagatgggaatcttagagaactgagata gaagcagggc[t/c]agcctcataattgaagggtccagtgcaaaatgaaaatgtagtactacttgttcagaaatc/c/MG C48628/similar to KIAA1680 protein/ 928/9/rs4563961/136809823/[t/c]/tgccacgccgtggtgagacggcaggtggttttctggggcccccagctc tgtgtcagccag[t/c]gtggccctacctgttctcttttcaaaactctgggggcttccagccaggattgctttggaa/t/ 10 COL5A1/"collagen, type V, alpha 1"/ 929/17/rs1469587/68247582/[g/a]/ttagactattagtaacatttctgggggagtttaaagttatatgtgggt tttcaactgtgc[g/a]agggattggcgcccctaatccctgcattgttcaagggtccactgtaaataaaaaataatt/a/ SLC39A11/solute carrier family 39 (metal ion transporter)/ 930/21/rs2298679/34169330/[t/c]/gggtgtggggctggactgagacctcaaggatgggaccattcactgctt cccgcaatgcca[c/t]ccactggagccatcaaggagtggccgtcatctgctacgtgattgccatgtgggtgctcag/c/ ITSN1/intersectin 1 (SH3 domain protein)/ 931/3/rs1840673/158600671/[t/c]/tctgttttcatcagctatttctcaacttttattactgggatttatttt aaaaaattgttt[c/t]gcccagacagctttgttttactaagcgtgatttattactctcccatgagcccacaaaaag/t/ VEPH1/ventricular zone expressed PH domain homolog 1 (zebrafish)/ 20 932/8/rs10110943/18656892/[a/c]/attcatgatgtgaccagttacattcatatcaataatacatgctcatgt tagtgagagggg[c/a]agcaatcttggactgttatgacactttaaacatgctccaaacaaggccgggtgcagcagc/c/ PSD3/pleckstrin and Sec7 domain containing 3/ 933/9/rs3887368/9016457/[c/t]/ccttgctgtgtcacatttagacaaagaaagacccagtttcttaaactgtc taacagataa[c/t]aggcttgatctttattgtcttcctcattattatcatggtagctctctgttaccttactat/t/PT PRD/"protein tyrosine phosphatase, receptor type, D"/ 934/10/rs2358291/19408262/[g/a]/attctacgtatttgtgaatttttctgatttcattctgttattaattta aatcattctgtt[a/g]tacctggagaacatacttgtatgatttgtatgctcttaaatatattcagatttgttttct/a/ LOC100130846/hypothetical protein LOC100130846/ 935/11/rs1007018/132454683/[c/t]/aaaaatggctaaaacaaatctgcccgagtactctacacttgttctgg 30 ggtgacaaaaaaa[c/t]gactgtgacaccctgcaaagtgcacagccaggcgtggccacccactgtaagaacctcggg/t /OPCML/opioid binding protein/cell adhesion molecule-like 936/7/rs2116531/14421132/[a/g]/tgtactctggtgagactctataggagggtttttttttattttttgtttg tttgtttcaac[a/g]tagatcacatcagaaagtcttgaaatgactaggtgctttcttcagagtatttaaatttta/a/D GKB/"diacylglycerol kinase, beta 90kDa"/ 937/12/rs3782362/71171821/[a/c]/gaaaggcacaaaatcacctgagatattcttataaaatataatcgcttt ttaagtttatgc[a/c]ctgattaaggcatcttagagattttgtagcttggcattgaatgaaatgtagttgatggct/a/ TRHDE/thyrotropin-releasing hormone degrading enzyme/ 938/9/rs7037313/133154314/[t/c]/gcacacctgtgaccacttacacgtgtccttctttccatccccactgag ctgtgagctttt[c/t]gcagtgcgcccagcactgacacactgccaggcgctcggaaactatttacgggttgcctga/t/ 40 PPAPDC3/phosphatidic acid phosphatase type 2 domain containing 3/ 939/3/rs11916040/126743742/[t/c]/catgcagcagcatgtaacagaaacagacttcctgcataaacagaaga tacaaaggcagag[c/t]ttaggaatttaaaagtaaaagcttgtaccaaactaccgtaagaaaggtatatttaaaaag/c /OSBPL11/oxysterol binding protein-like 11/ 940/5/rs9313469/169049436/[c/a]/gaatataattaagtcatagatgactaacgatctggtgggtccttagga tcatccttctaa[a/c]taccaatactcactgagcaagacatgtacgtagaaatgttgaaatcgattgttatttgga/a/ DOCK2/dedicator of cytokinesis 2/ 941/9/rs1930409/100318362/[a/g]/tcactctgcctgctggacagagggctccctttgcagaccttggggcca ggaggtgaaggt[a/g]gagtgcatcctcagtgttcttgtctccttcttttattaccattctctgattgtgatgccc/g/ GABBR2/"gamma-aminobutyric acid (GABA) B receptor, 2"/ 50 (98) JP 2010-88432 A 2010.4.22 942/15/rs2129774/51640623/[t/c]/tattatttgattttgagtatcataaactgcattgttcagaacacctgg aatttttacctt[c/t]aataaatgagacaactggtgtagcacattcaaccaaaaggacttcatttgaaattaattc/c/ WDR72/WD repeat domain 72/ 943/14/rs2272588/77093467/[a/g]/accttgaattgaaatccaaaatgtaacaaatgttcaaaaccatcgaaa cttgactaaagg[a/g]cggtggtggctaactcagttcattagcttccttataaaatgaccagtgtctcatgttaaa/g/ SPTLC2/"serine palmitoyltransferase, long chain base subunit 2" 944/17/rs1078545/68279579/[a/c]/aaggaaaatgcaacgtctcacatcatgctgatttcaaaaataatgcaa caaaccagtgat[a/c]ggcaaaagaaatggagatggtgttaaagacttggggtggggaaggaagggcaaggcacag/c/ SLC39A11/solute carrier family 39 (metal ion transporter) 945/6/rs6913557/1634362/[g/t]/gcaccagtgaccttttacatggacagacacaaagttatttttattaaatc 10 aagctgaggt[t/g]gtggttgtgtcagatatatatttttaaccatggtagagttgcaggaggaatggcctgtgt/g/GM DS/GDP-mannose 4 946/10/rs7078013/78308963/[a/g]/aattatctatgatcagttcatgaccactctgcttgtttctcctcagtt cctacttctgct[a/g]tttcaagtgccctgagctgtcaatgtcgaggagggctgtcactggagctgggatatgcct/a/ KCNMA1/"potassium large conductance calcium-activated channel, subfamily M, alph a member 1" 947/5/rs1545751/177913398/[t/g]/agtaggaggccactgggaatcttcaggaggggaagagcgagggcttgg cagactttactg[t/g]cacgttcttctaggacgtgggtatgaagatgctggcgatgctggagtgagagaaacagaa/g/ COL23A1/"collagen, type XXIII, alpha 1" 948/2/rs7591687/45609173/[g/a]/ggtatatcacagaataagaaatcaaagagtacaaacattgtgcccaaga 20 gaattaacatcagtaaaggagggacttataaaagaatttaaaaaacacataaaaaataggtttgggagcca[aa/gg]gc aaaaagctaaatttggttgaaactgaggtaccagaggggtactctagagactagcataagccactgaatctgagtccatg tctctggtgagaacttgaaactatgtagacttagaacc/a/SRBD1/S1 RNA binding domain 1 949/4/rs6824270/110792788/[t/c]/ccaaatcaccacttcttgtaaagacaccagttatgtcggattagggcc tatactaatgac[c/t]tcattttaacttaacctctttaaagtacagtcacattctgaggtactaggggttaagact/t/ CCDC109B/coiled-coil domain containing 109B 950/5/rs11748071/160854123/[a/g]/gaaacacatttacactcacaatttaaaaggcagtgggaatatattta ctgttaggtatgc[g/a]tgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtacaattactgacaactgaaaaca/a /GABRB2/"gamma-aminobutyric acid (GABA) A receptor, beta 2" 951/5/rs6868503/169428629/[t/c]/gtctctccagacctgttactcttgttccatccacatgcctgtgacctc 30 atccttgcccct[t/c]tcaaattgaatcttctcccagtgccaaagagattggctgtgaaatgccacatgaacagga/t/ DOCK2/dedicator of cytokinesis 2 952/6/rs2023053/162460319/[a/c]/ccagccttcaaggcaaaacacaggttggcagcttattcacagtccttt ccctgatcatcc[a/c]gaggccccttgatttaaagccctgtagactttgtgccaattgcaggattaccgagcactt/c/ PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 953/11/rs7925621/44243725/[t/c]/tcacctccagctcctccccaggcccctcacatccataggcacctgagc aaggtgagcaga[c/t]ctcaactcggagagctttggcctcgcaggttcccttgggcccccaccagtagcagggaag/c/ ALX4/aristaless-like homeobox 4 954/5/rs4580739/59691437/[a/g]/gtaaattggtgtctgatccacctgttctctttcttatccatctaccccc acaaaacacac[a/g]ccttctcccatgtttctagtgccatattttcttacccaacatgacatgctccttcctcac/a/L 40 OC653198/similar to phosphodiesterase 4D 955/5/rs1423246/59697213/[g/a]/ggatgaatcaatagatagataaatatatcacacctaaattatcaagttt ccctgaacagc[a/g]aaggcttagagcaggcactcttgtaccaagggcgctgagattacaacatttcttgaactt/g/L OC653198/similar to phosphodiesterase 4D 956/6/rs9397190/154782462/[c/t]/ggaaaacactacggaggtttcctgaaaaattaaaaagcagcctcacta ctggatacacgt[t/c]taaaggaaatgagatcagtatgctgaggagatatctgcaccctcatgttcactgcagcat/c/ CNKSR3/CNKSR family member 3 957/7/rs7776527/2693863/[t/c]/gcccgtcctcagggccactgactgtagggctaacctaggggcctggttca cccctctcac[c/t]tggggcttcgctgataagcctggttcacctcctcacctggtggcctcgttcaccccctca/c/AM Z1/archaemetzincin-1 50 (99) JP 2010-88432 A 2010.4.22 958/18/rs4798110/3707383/[a/g]/ctttctcaggctgttcatccacttcgtgttctttctctgcactttcttg tccaaagcccc[g/a]tggaggtgaaattcctacccacccttctttcctgttccctctcttacctgtgataactaa/g/D LGAP1/"discs, large (Drosophila) homolog-associated protein 1" 959/8/rs7005312/56968993/[t/c]/ctcactatgttgcccaggctagagtgcactggccattcacaggcacgat tatcactcaca[c/t]actatggtcctgagatcctgggctgaagtgatcctcctgcctcagcttctcgagtagctg/c/L YN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 960/14/rs1245214/26005061/[c/t]/aacatcttcatcgctttctagtctattcaaaattcaccttctccataa ggcttacctgac[c/t]tccttatatggcaacctggcctcccccttccccccctgtactcctgattccctttatcgt/t/ NOVA1/neuro-oncological ventral antigen 1 961/1/rs2185029/111887553/[t/c]/ttccagggagattcgctgccaaaagggaaaaaccatcctgtctggtct 10 caccaaatacca[t/c]ctcccgtctattcgccactcagcaaccagagtgatctcttagaaacataattgggtcata/c/ ADORA3/adenosine A3 receptor 962/1/rs2999967/161433300/[t/c]/atacatgaatgaatttacagcaaatagagacaagagcacttctaggac agcttggtattt[c/t]ctctgctttccttgggtattggggagaccaagaacagtatcagtgttgacattttaggcc/t/ RGS5/regulator of G-protein signaling 5 963/9/rs4842145/136736770/[t/c]/cccctggaaggacaacttccgctcattcaaagccaatctgttctgtgt ttagagttatac[c/t]gaacaaggattcaccaaactctaagagagttcgtttaaacagggactgggggtttttcct/c/ COL5A1/"collagen, type V, alpha 1" 964/9/rs2312735/93645729/[g/a]/acttctcctaaagggctgtgacccccaatcccactagcttgctcgcact tagaaattact[a/g]tatgtctagagactccacacaactacagttcctccgcatgcatgtcgatgtctgcaggtg/a/R 20 OR2/receptor tyrosine kinase-like orphan receptor 2 965/9/rs1881385/93636602/[g/a]/gctgacgacgggactggtggggtattttgtcccagctattccatgcata aggtgtagaga[a/g]tatgtcttctgccatggctagagttaaataaaggaaaattcatgccaggctgagttcagg/a/R OR2/receptor tyrosine kinase-like orphan receptor 2 966/15/rs2554430/22745575/[a/g]/ttgcagacatgaggcaacatgtcaggcgtttttatggttctttttata tgttctgttaag[a/g]attggcaaatccaggccaagtgtggtggctcacgcctgtaatcccagcactttgggaggc/g/ LOC647795/hypothetical protein LOC647795 967/17/rs701982/42599821/[c/a]/ggttgtgataactaggaaaaacttgatagaaaaagtaaaatttgacaac atctcatatct[a/c]tagagtgacttccagaggaaaatagatgttcaaagactacaaattatttgagaggagtga/c/C DC27/cell division cycle 27 homolog (S. cerevisiae) 30 968/3/rs9831010/28308600/[t/c]/tcagtctacttctctcaaaaacaaagagtgtttttagcgggaatttgca aggtattttaa[c/t]tcattttctttccccagtgcattctaggagctaggatccatggcatgttgagccttgcca/t/C 3orf68/chromosome 3 open reading frame 68 969/11/rs631647/128134145/[g/a]/catcccaggtcctttccctgaggcatcagagtaacgctagagtaagga ccataaggaagt[a/g]aatatcccagtcctgtttgagaagggagaaagctggtgctctgaggggtttcgatgactc/a/ FLI1/Friend leukemia virus integration 1 970/12/rs1385374/127866647/[t/c]/ttccaaaaggctcaaaaatcactgacttcctggactcaaacaaaagc actgaggtaataa[c/t]gcaacatctaggcttatggagttcacgaggctacttcaatggagcccaagcggtgggaac/c /SLC15A4/"solute carrier family 15, member 4" 971/12/rs7315271/37450998/[g/a]/aattagatccctgctgtactctcataatatatttgaatcacttgtcac 40 atatcatgacat[a/g]tattacctgcatagtcagccgactaatgtctctctttcccacaaactatgtgttcattaa/a/ CPNE8/copine VIII 972/6/rs9386046/144095189/[t/c]/caccagtctcccagctctactttctatctctgcgggtttgcctattct tgatatctcata[c/t]agatggaatcatacaatacatatgtggtcttttatgactgatatctttcacttagcaagc/c/ PHACTR2/phosphatase and actin regulator 2 973/11/rs3847535/92197672/[a/g]/gtatatagaatactatgtacaatgtcacaataaagatgtaaaagaata tataatggcata[a/g]aaatatagttgcaggtcatcaaaaaagcaagttacaaaataatatctagtttatgagcct/g/ FAT3/FAT tumor suppressor homolog 3 (Drosophila) 974/11/rs12296005/8718738/[g/t]/ctggagctagttgggaaaaagtcctagtagtcctggaaacagcctgag aggtaccatgag[t/g]gccatgagtgttatgagtgccatgaagtgagcctgtctgcaggtgaaggttatacagggc/t/ 50 (100) JP 2010-88432 A 2010.4.22 ST5/suppression of tumorigenicity 5 975/6/rs2763122/7426927/[t/c]/tgctatacaagcagaagacattgaagacttggtcacagttcatcttagac tgatccaaac[t/c]gtagaccatgaggacagggctgtcggggtgagggccatgctcgggtggtggggagggggt/c/LO C442157/similar to heterogeneous nuclear ribonucleoprotein L 976/9/rs7024493/127752063/[a/g]/ttgcctgggagatggctccacctttcagtgtagctgatgggaggcatt tccacagttgtg[a/g]tgtcagtgtttcaaaatctgtcaaagaggctctccatagagcctaggaaggaaaactatt/g/ PBX3/pre-B-cell leukemia homeobox 3 977/19/rs888932/4243597/[t/c]/atccccccttttttgtgtgtacctatgggtggggtcctgttgaggtctcc tgggatctct[c/t]actcctctcccactttggggaacccttttggcctcggctgctgggtggggcttggtctag/c/TM IGD2/transmembrane and immunoglobulin domain containing 2 10 978/13/rs2281991/101164826/[g/a]/agtaatagcctttgtaatttcaggttcttgtcattgtgggaagtgca tttgttctgctga[a/g]gagtggtatatttctggggagttctgtgactgtgatgacagagactgcgacaaacatgat/a /ITGBL1/"integrin, beta-like 1 (with EGF-like repeat domains)" 979/3/rs4974096/51368086/[t/c]/tttttgtggaaaaaaagcagataagagtccacttgccctcccttctctg aaacaagcttg[t/c]catagtcatggcaactgtcatgtggtccccaaggaagctgtgtgtgaaaggtgaggggaa/t/D OCK3/dedicator of cytokinesis 3 980/13/rs4063/113879204/[a/g]/gcctctcctgagccttgcctgctgcttgagctctttgatgacttgtgagt gtgagtggac[a/g]catgtgaaggtgtgtgcatgacataaacaagtctccattaatcagccgcaggaaggagtg/a/RA SA3/RAS p21 protein activator 3 981/21/rs2268284/35142549/[t/c]/ctagcaagagaggtatcatgcagtccattctacagatgggaaaactgt 20 gaaacgcagttt[t/c]agacttgaagctccaaactcctttctcgctcaccgaggctacctgagcaccctggttcac/t/ RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncoge ne) 982/15/rs2292915/71377632/[c/t]/agactccattcttatccctggcagtggtgctaatccatgttctcttgg actagcactgat[c/t]gcaagtgctattgagctggtttagggaacccctagaagtagccaaactgtgggactgtca/c/ NEO1/neogenin homolog 1 (chicken) 983/1/rs898388/202766880/[t/c]/tctttcagcttttggctgaaatttcacttcctcaaaagaacattttctt gacctctaaca[c/t]tctaaatcccacccactccctgcttcatgtatctcttttctgtagcacttgccatagtgt/t/M DM4/Mdm4 984/17/rs10512453/29090113/[a/g]/agtcttggaatgttactaaagtttccaaggaagaaaagaccaaaagc 30 attatttaaccac[g/a]atgattcttttgtcctggtttgcccatgtttaaggtaagaataacagccccagttctggc/g /ACCN1/"amiloride-sensitive cation channel 1, neuronal" 985/5/rs10475944/169873337/[g/a]/ataatggatttcactgataatgttcagaatcccagagcaggatggca gcctggtttacat[a/g]cagagcctttgtgtgggatttgaagccagaaaatgtgactaaagtaggagtctaaacaga/g /KCNIP1/Kv channel interacting protein 1 986/10/rs1993853/67443315/[t/c]/aaggttttcattgacatcaaagcctcttgcagaaacatttgaaattat cagttaaaagcg[c/t]gttagcaaaatactagtgtgtgatgtgtgtatgtgtgtacaaaatatacacatgttatta/t/ CTNNA3/"catenin (cadherin-associated protein), alpha 3" 987/1/rs737524/27053416/[c/a]/gcctccatgggctgctttggtctgtgggctccttcattcccttggtgata atttcccttt[a/c]ttctgtgggatttttggtggggttttccccccttttttatggagttggccaataggattg/a/ZD 40 HHC18/"zinc finger, DHHC-type containing 18" 988/22/rs4646316/18332132/[t/c]/aggtgcaaaatgggtggcagaagtggggtgcacaccccagaccagaca ccagggcagaaa[c/t]ggcacaggaccaaggagatggggtggggaagggccgctctgggcccagcctgctctcccc/t/ COMT/catechol-O-methyltransferase 989/16/rs9936141/17136599/[a/g]/tagatctggcaaccccaggcccacactccacatggtaacaactggtta aagctgaagggt[g/a]gtggctgttcctttagacagcacctaggttcttctgctcactgcagtctccaccatgccc/a/ XYLT1/xylosyltransferase I 990/11/rs1238566/128120696/[g/a]/ttcctgacttgatgggcctgaggtcaccaagcatggctcagccgtga atcacggaaaaga[a/g]gcggccattaagagctggaaaacggattcagggtctcccctgtccccatgccctgagagg/g /FLI1/Friend leukemia virus integration 1 50 (101) JP 2010-88432 A 2010.4.22 991/2/rs587201/134940823/[t/c]/ttcacacagggcaattgagagttcatagacatgggtagagaaaatagca tctaaaaatat[c/t]gtctgctactgacgttatcttaacacttcctctaagttgttaccttaccttcgcaagcaa/t/T MEM163/transmembrane protein 163 992/1/rs1052571/15723200/[c/t]/tcctgcggcggtgccggctgcggctggtggaagagctgcaggtggacca gctctgggacg[c/t]cctgctgagccgcgagctgttcaggccccatatgatcgaggacatccaggtgcgcccccc/c/C ASP9/caspase 9 993/1/rs4646018/15712961/[a/g]/acaatcctatgaggttggtagttgctcctattatcctgtaatacagatg gggaaatcaga[a/g]gcccagagactctgagctccttgcccattgtgacacaggtgctaagtgttggagttggga/a/C ASP9/caspase 9 994/14/rs2295977/23727066/[g/a]/gttttgaagactaaagttcttgaggaagggtgatgatgatctgccaaa 10 cccaagtcagaa[a/g]aataagactgaaattcaggctaagttagactgaacttaccagattacatgcccacagtgc/g/ IPO4/importin 4 995/12/rs471231/116671720/[g/a]/taccataggaaaaaaatctcaccgtcataatatcatcagtttgttcct gtaaataataag[a/g]gactgcaaactaaatactctgttacccaacccacagaacacttcaccacaaaaattcatc/g/ KSR2/kinase suppressor of ras 2 996/13/rs7400029/113611527/[a/g]/ccacgcctatgtgcagggaaaaccgcgtggggtcggcggggttagct gagcaaaacccac[a/g]tgaatctcagtgctcctgctcacctctgtctggtagacatcgtacaagtaccccacccca/a /FAM70B/family with sequence similarity 70 997/11/rs1612783/15142305/[g/a]/gcaacagaaagttattgtagtctcatcccatatatagttattttaaaa agagaataaaga[a/g]cagaataatatctctacaatgagaaaatgccagaaaaaaaatgtactcttaaaacagata/a/ 20 INSC/inscuteable homolog (Drosophila) 998/8/rs4265186/14828107/[a/g]/atagatattaatgcaaacagctttttaagtaatatatgcatgttcttat actcatttgtc[a/g]ttcaaattttggacaattttatataaaataagcataaaaaataataaaagatcatcgaaa/g/S GCZ/sarcoglycan zeta 999/1/rs343376/42466184/[t/c]/tataatttctttacctctaggggtcctactgggcaatagacaccaatccg aaggaagatg[c/t]gctgcctactcggccaaagaagagggcacgatctgtagaacgggtaaaggctctttatca/t/FO XJ3/forkhead box J3 1000/3/rs4312609/193732314/[a/g]/gatgctgtcactgacaccttgagttgaggaatataagtagcttttgc ttaggaggtgtta[a/g]tctgatggcagcttatttggatagtgctttcttgtttgttagttgtttttagtccatggt/a /FGF12/fibroblast growth factor 12 30 1001/9/rs7047795/5171467/[t/c]/taattgattagtagaaagtgttcagaaaactagctccctatgtagagaa aaaaagactta[c/t]tgagaaagtgaggtaatattcctaccgagaccagaactaaaaattagcctaataattaag/t/I NSL6/insulin-like 6 1002/10/rs7923245/73004416/[g/a]/tcccgtcatggaaatggggtagggggtgtcccggctgagcttgctga gcaggaggaggac[a/g]tgggtccctgaggccaggaacagcccagctgggctcctgtgtccacggctttcctgacaa/a /CDH23/cadherin-like 23 1003/10/rs4582885/117226272/[c/t]/cttatttttacattctgtatttttatcttgcaaatgacctttctgg ccttaacctttttt[c/t]taactcttgcttagcttttgtctaattgtgaatataacctccccttatacctaactacta/ t/ATRNL1/attractin-like 1 1004/10/rs7100684/117247095/[a/g]/acctagatgttctagttgaagggctagtgttgctcaccactctctt 40 ctctccatgaaagt[g/a]gtgcacactaattggttctaatcagccatcttgtaaagtctcagtgtaagttaagtttac/ g/ATRNL1/attractin-like 1 1005/10/rs1953601/117310510/[t/c]/cttctgtattttcttctaagagttttatagtttaggtgtcacatat tggtgtatcgattc[c/t]tattgactttatttgtgtatggtgatacgagtaatgggtccaacttcactcttttgcttg/ c/ATRNL1/attractin-like 1 1006/11/rs2106467/2592373/[a/c]/taacaaatggtgctggggcaactggatcctcatatatcaaagaatgaa gttggacccata[c/a]ctcatagcatataaaaattatctcaaaatgtatcagagaccaaaaaataagagttaaagg/c/ KCNQ1/"potassium voltage-gated channel, KQT-like subfamily, member 1" 1007/17/rs854771/18000917/[t/c]/gcagggtgagggcaacagccctatcaccccactcccagaggcctaggg ccacccctgctc[c/t]tcacatccttcctgactcatcagggaagggagccttcattaggtgagaagagggaagggc/c/ 50 (102) JP 2010-88432 A 2010.4.22 MYO15A/myosin XVA/ 1008/3/rs1129055/123321009/[g/a]/cctaatcttttcttctatttctccagagaaaaaatccatatacctga aagatctgatgaa[a/g]cccagcgtgtttttaaaagttcgaagacatcttcatgcgacaaaagtgatacatgttttt/a /CD86/CD86 molecule/ 1009/11/rs4930131/2576372/[t/c]/cacaaagttttatttgtatacatggacagacaaaatgtacattgagat ggattgtgtata[c/t]atacttattcattgcctcatttaggtctgctctgcccttagttaaaaaaaaaaaacccta/c/ KCNQ1/"potassium voltage-gated channel, KQT-like subfamily, member 1"/ 1010/11/rs10501705/88827923/[c/a]/tccaatagctcctataggccatatacattatgcttagttgccagta aagtatgttagtta[a/c]acacaggtcttgcgtttcatcttccatcaagcatgactactttagtttattacttactca/ a/NOX4/NADPH oxidase 4/ 10 1011/16/rs1291717/4216057/[a/g]/tgcttgctttgctttttgctgagaatgttcatgcttcccagacaaccg tctgtctgactc[g/a]ctccttcctcttctaagtctgctccaatgtcaccagctccataaggccttccctggccac/g/ SRL/sarcalumenin/ 1012/16/rs7196583/81702351/[c/t]/aaaaatagaaatggcaaggaataaaatttgccttcaatgtgcttatg gtcttgggaggag[t/c]agagtaaaaaaaatccctaatttctattgatataatatcattggatagtgccatgataga/t /CDH13/cadherin 13/ 1013/18/rs500559/32524192/[a/g]/ttattattaaatcgtgagtgcccactacagttcttggcacatgacagg cacttgacaaac[a/g]ttcaataaataaatgaaaagatgaatgaacaaacaaatgatataggcagaggataaacgg/g/ FHOD3/formin homology 2 domain containing 3/ 1014/18/rs502154/32524314/[a/g]/aatgtttggatgaaggcagcaaaagtaggaagtcttttcttggggctg 20 tggtttgtggat[a/g]gaaagcccggtgcttcccacagaggaggctctgtcggtctgtggattgagtgtggcttcg/g/ FHOD3/formin homology 2 domain containing 3/ 1015/19/rs3813777/8102222/[g/a]/cttagtcccaaactcttgcccaagaccagagggcctcatccttgcctg tggctgaatccg[a/g]gccatggctaagctccctgacccgtctcactctgtccctccatccccagctgagttccag/a/ FBN3/fibrillin 3/ 1016/18/rs1484874/41464192/[a/g]/acacccacagtgcctagaaaagatctaggctttgttgctgacaggtc agtgtcttgttct[a/g]catcataggctcaaagctctagccactggacacaacatccatacacatatcttctaagga/a /SLC14A2/"solute carrier family 14 (urea transporter), member 2"/ 1017/22/rs134558/27787622/[a/g]/tttctaaccaactgccatgcaccaagaagagctcattcacagggaaat caatatactctg[a/g]ggaccataaaagcaacacgaaaacattaatgctgccggcctccatttcctgggaccaact/g/ 30 C22orf31/chromosome 22 open reading frame 31/ 1018/7/rs10236110/151172250/[a/g]/agcgtggctctgaagttgtggcagtgtccctcagagactggtcact cactactacagacc[a/g]caggcaggccagtgctccctctgggcctcagtgtactcttctgtaaaatgggaagatcat/ g/PRKAG2/"protein kinase, AMP-activated, gamma 2 non-catalytic subunit"/ 1019/7/rs6958752/7876424/[g/a]/aatattaattttctttgtaagattaaaaacatctgacacggtatgctca tatttaaacta[a/g]gtaagggcaaccgctaataatttgaaaaagaagtattaaagctaggtttatgaagaaact/g/L OC729852/hypothetical protein LOC729852/ 1020/1/rs437021/61510858/[a/g]/agaccttaaagatgttcaaaatttagataagttttagtttctgagggtt tgggaagataa[a/g]tactctgcagaagaggccaaggaattcatttttctacatctataaggttgtaatagagaa/a/N FIA/nuclear factor I/A 40 1021/1/rs2510/202428214/[c/t]/ttttcaaattctccacaaagaatctgaggtcaccgataaagcaaggttgc atatgaagtt[c/t]cttctcaacatcggcacagagaggttgctgacgtagagcagagaacacagtgtgaggaaa/c/KI SS1/KiSS-1 metastasis-suppressor/ 1022/1/rs1048635/117456381/[t/c]/tgctcagccttttaaagctgcaggcagcaccacttgagatttccaga ggacccagacctt[t/c]gttcattctaaagagactgatagaattaaaaacaaagtgccttatcttgcactggagttc/c /TRIM45/tripartite motif-containing 45/ 1023/11/rs2155314/125875275/[g/a]/catcaggtggctttggggaggctgagattcctgcaactactggcca aattccacctaatc[a/g]tactccgacaacccaacagcatctaataataaagacaggttcaaggatctggacctgggg/ a/KIRREL3/kin of IRRE like 3 (Drosophila) 1024/3/rs7636169/135194886/[t/g]/tcctgcttccgttgttttgtgttgtgtttcttttctaatggtgccct 50 (103) JP 2010-88432 A 2010.4.22 gttcaaagctcag[g/t]agtaggaatggagcatgtggatagctggagtggtgaggtctgtgaaagaaggtgaaaggg/g /SLCO2A1/"solute carrier organic anion transporter family, member 2A1" 1025/1/rs11247594/26940004/[g/a]/agaataagtgggttctgtgtggtggaatatttaaagattttgattga ctggtgggcaggg[g/a]gagtctcatttttgaggaaaagttaaattccatatttattttgtggaatataatatagta/a /ARID1A/AT rich interactive domain 1A (SWI-like) 1026/7/rs756668/103957796/[a/g]/aattgtccttggtacaacttctgttggaatgttaaaaatagtgtgatg tttgagtgaggc[a/g]ttgagatatttggaaataaaagatgataggactgactaatcatcagtatgattgcaactc/a/ LHFPL3/lipoma HMGIC fusion partner-like 3 1027/7/rs9648932/104103295/[a/g]/ctaaaagcagataaagcaattaggagtcagttgcaacaatccaggtg ggatatcatagca[a/g]cttccattagggtgataacagaggaggtaaagagaaataatcacattttgagttgatttt/a 10 /LHFPL3/lipoma HMGIC fusion partner-like 3 1028/9/rs1444832/74497539/[a/g]/tacaggtgtgaggtatcgcacccggcccataataacttttctaactgg gcttggaaaact[a/g]tatatatattctgtcatccaaatcaagaacgagtttctgtttgtttaatattgtggcaaa/a/ TMC1/transmembrane channel-like 1 1029/15/rs3784807/71418883/[g/a]/ccaggcagcctggggcaagctttccccagtctgtgggaggcaagctc cctagccccaacc[a/g]agggcatcctccttcacgttccgtgagctacaacaaggtcttcagaatcagctaacataa/g /HCN4/hyperpolarization activated cyclic nucleotide-gated potassium channel 4 1030/18/rs2644254/32460438/[a/g]/gatattatatgtatttaaagtataaagtttgacaaaatctgccaaac ccagagtggttct[a/g]tagtatagaggtacaacaaaaggctggccatgcctgctccagagtctgggtccagttgta/a /FHOD3/formin homology 2 domain containing 3 20 1031/17/rs9900506/76236971/[g/a]/gagtgctcacactgctaggtgtggtgggaggcgcctagtcaggcagc cgggttggctttg[g/a]ggagcactgcatggatggcttctaagatccacttgtcttctttcccctgggatgattaga/a /KIAA1303/raptor 1032/11/rs1996352/101901457/[c/t]/aaaaaaaaaaaaaggcagcccagtgcaagtagctgacattgttatg tgctgtcggttgca[c/t]tcacagggtagtttgggtgctttcttggcccagacacttttcctttcacagaaccattgc/ t/MMP7/"matrix metallopeptidase 7 (matrilysin, uterine)" 1033/1/rs783622/42139575/[t/c]/atctcatctggacccctctttggaagaactgattgtaaatgcagccccc ttcttagcatc[c/t]ccacttagatgactcaacacacgcataactcggctcagcaccttcccacatgcatgacca/c/H IVEP3/human immunodeficiency virus type I enhancer binding protein 3 1034/6/rs1304029/71679974/[g/a]/atttgcatgtagctgtatgttttgaatgatcttcttggggctgatttc 30 tacttttgttgc[g/a]ccatggtccaagagtgtggttagtgtgattcttgtgtttttaatttgctaagaattgact/a/ B3GAT2/"beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)" 1035/7/rs2240100/44433254/[a/c]/aattctcttttttcctaaagattaaatctgccttcagtttccctaaga aaagtccagtct[c/a]ctaaacgcacagtgatagctaacatacattcacatagcatctgtcatgtgagtttcctgg/c/ NUDCD3/NudC domain containing 3 1036/9/rs4240702/136735680/[t/c]/tttgtcatgcagtctcttttttgtgctgtgtcaaatctttgtaattt ctagtgtgttctg[t/c]tgtaaagattcaggaaaaagctttattttatctttaaaaaattaggatcctaaaacaaat/c /COL5A1/"collagen, type V, alpha 1" 1037/3/rs2271487/39206001/[c/t]/ctactctgactctgagccctgtttactaccatttctcccagcatccag cctctaccctgc[c/t]gaacatctagatctaaggctcccaatcccatcctcatctctgccccttcttctcagaagg/c/ 40 XIRP1/xin actin-binding repeat containing 1 1038/1/rs943762/176175475/[t/c]/cctgagcgtcagctatgtatatgctcagttcatcattttgggtacctg ttgttgttcctc[c/t]ggctcccgaaatatctgagcgagtaggatgaggatccccaatgtctcctgctaccttttg/t/ SEC16B/SEC16 homolog B (S. cerevisiae) 1039/1/rs1377733/77592331/[a/g]/gactggatgaacttgacactctggaacagagattattccatgcattca agaagaaatgag[a/g]catctgaaatttctaagtggagttacagccattaccaagttcaggattggaaatgggagt/a/ AK5/adenylate kinase 5 1040/8/rs6993992/59511607/[t/c]/tctttatcacgtaagacaaatctcctgttgcagtgcatctgacatccc ctacctcgacac[t/c]gaatgacagcagtgctcacagatcacaccatgatgtttagatggtttagatgttttgtcc/c/ LOC137886/hypothetical protein LOC137886 50 (104) JP 2010-88432 A 2010.4.22 1041/12/rs1674091/112012971/[g/a]/agtcctggccacgtgatactatcctgtatagccgagcagccaccaa gtgggtgtgtgtgc[a/g]ctgcacctgtgtgcatgtgtgattgtgcctctgcatgtgtgcaggtgtgggcctcccagg/ a/DTX1/deltex homolog 1 (Drosophila) 1042/17/rs4985721/16933269/[c/a]/caaacttagtggcttaaaacaacacatctttgttctctgatggctct ggaggttgagagt[c/a]caaaatgagtaccacttagctaaggtccagatgtgagcagggcagcttccttctgaggtc/a /M-RIP/myosin phosphatase-Rho interacting protein 1043/6/rs4712802/10750245/[t/g]/ttctcctctgtgattggatttctgacattttatctaatgtctatttct cttcatatccag[g/t]ttgggaatccttttagaaaaggctcagtcatattcagtgcccttaattccttatacacgg/g/ GCNT6/glucosaminyl (N-acetyl) transferase 6 1044/3/rs1915087/123321481/[t/c]/tcaatttctggaaaactgccttttatctgcccagaattctaagctgg 10 tgccccactgaat[c/t]ttgtgtacctgtgactaaacaactacctcctcagtctgggtgggacttatgtatttatga/c /CD86/CD86 molecule 1045/2/rs188147/200492230/[g/a]/tgaatggataaacaaagtatatatccatacatagaatactactctgta aataaaaggaac[g/a]gactactggctgggcacagtggctcacgcctgcaatcccagctctttgggaggccaaggc/a/ FLJ38973/hypothetical protein FLJ38973 1046/7/rs6583458/48250516/[t/c]/ctcatggttaattaaggcatagttagcacacatacatgtacatcgtgc acctctccatgc[c/t]atcaggcttgggcaagaatgatctatttttgtgtaatgttgatgacaaaccacagtgcta/t/ ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13" 1047/1/rs1606357/214587714/[t/c]/atcattgtatgtcacagaactaaccaaaatttctttatcaattgtgg ctttaatatatgt[c/t]gttctaaaactttttgtcatccatagaaaattgttgacctgttttaatcctctttaaaaa/t 20 /USH2A/"Usher syndrome 2A (autosomal recessive, mild)" 1048/15/rs3743338/34771701/[t/c]/acggaccactagtggactgcatcaagcagtatcctttcccataaaat tttaggtgcgcaa[c/t]tgacgagcttagactcagtggagatgtgtctagctttaacctgacataaagttctgcttc/t /C15orf41/chromosome 15 open reading frame 41 1049/14/rs3917192/75501427/[a/g]/atgcattagcctctggaagacaacacgtactggtaagtggtgaaact gtgtaggcaagcc[a/g]tctagcctctggtcctagtgaaatgggatgagagttcctctttcacagtgttgtcaggca/a /TGFB3/"transforming growth factor, beta 3" 1050/3/rs4684306/16991131/[t/c]/agaaatgtccaggaggcaccttaacatacaagtaagatgctcttgaga gctccagactta[t/c]gtttcccaaagggacatgatctctcctgcctgggtcttcacagcactttgtatgtctctt/t/ PLCL2/phospholipase C-like 2 30 1051/4/rs3108956/110225774/[t/c]/tgcctgttctccaaggttttgtgccactgtcttctctatctactctc tcatccattgcag[c/t]tggggctccatcaccattaccggactgagtcctgcatctaaagagtccgctgagccccat/c /COL25A1/"collagen, type XXV, alpha 1" 1052/1/rs7525092/1799950/[t/c]/catctttttcagcacacagccttttccactgtcgcataggtaacattcc tctcaccaagg[c/t]aagttggcatctcttattcactgcccatcacctgcctctccttggcacatctttggccct/c/G NB1/"guanine nucleotide binding protein (G protein), beta polypeptide 1" 1053/5/rs12659024/45453447/[t/c]/attgcctccagcaggtgactggaaagaatacagtgtgatattcttaa ttgtgatatccaa[c/t]ataaagctgagaattttttagaccttctgaatgtactcaaaaatataaataaatataaca/c /HCN1/hyperpolarization activated cyclic nucleotide-gated potassium channel 1 1054/3/rs11925441/5172539/[t/g]/ttggtatttctattttgttcgtacatagttttcttgcatttttctcag 40 tgtttttttttt[g/t]ttgttgttgttctttgagtacctttaagataatttttgtgtgtgtgtgtgtgttgttttt/t/ ARL8B/ADP-ribosylation factor-like 8B 1055/4/rs10049581/103411916/[c/t]/aagatagacatatacaatatatgtcttccctgccttcagtgcctct gcaagcaccatcat[t/c]catggacttatagtgcaactgatatatagccaaggtttcctgtgaaaactatctcctaac/ c/SLC39A8/"solute carrier family 39 (zinc transporter), member 8" 1056/19/rs4807527/3861933/[g/a]/tcgccctttcatcaggtgagacggggaggctgcaacccaagtccagtg gcctcagtgtgc[g/a]tgtgtgcgtgtgtgtatgcatgcatttgtgtgtgcatgtgtgcacgtgtgtgcgtgtgtg/g/ ATCAY/ataxia 1057/10/rs1624281/30029188/[t/c]/tgctggtaggttggagtgtttgcagggaaatgttcatcaaagggctt gctctgtgaagaa[c/t]gtgacttaggatgatctttattttacgtgcattccatcatatgtaaacaaagttagggtc/c 50 (105) JP 2010-88432 A 2010.4.22 /SVIL/supervillin 1058/2/rs11123966/97932800/[t/c]/tatttatttttacaccccacacagggcttgcttcttttggttacttt tatacaatagctt[c/t]tgaaggattccaaatcatcatctcacatcaactacatgaaggccttactccaaaattgca/c /TMEM131/transmembrane protein 131 1059/1/rs1887404/71152639/[a/g]/aattgctaggatttgattgagataacatgtgtaaatcatttggcacat tgctggaacaga[a/g]ttggatctcagtaaatggttgtcatattttcttataattatcaacctcattcctgctatc/g/ PTGER3/prostaglandin E receptor 3 (subtype EP3) 1060/6/rs1954926/162436610/[c/a]/agtaaatacagatatttaggcaggtatcagaaacattgcacaggatt gtgagttattctg[a/c]agatgtaaaaatataaaattcattacattattacttaaattaataggtcagcgatcgtaa/a /PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 10 1061/5/rs2304060/149481944/[a/c]/cactcacacactcactcatcttccttcagtctatcccagtaggaaag cctgtggatcaag[a/c]cttttcaaccaacctgctgggccaagctgggcactgaggctaccaaaatgacagttagaa/a /PDGFRB/"platelet-derived growth factor receptor, beta polypeptide" 1062/2/rs763713/71301963/[c/a]/ctttaagggtgagtaggaatgctttccaggtgaataaaaccttcagaca tcattccaaac[a/c]gagactagcaggtgcaaaggcacagagatatagagatggtgaagtttacttatgtgctgt/c/P AIP2B/poly(A) binding protein interacting protein 2B 1063/11/rs2653565/8849769/[a/g]/ttttggagctttcggttgagaccaggctccttggaaccctagtgcttt gggagttctgct[a/g]ctgctgcagtaccaaaagtagcttctttgaatttcatttgggttttgtagggctcccccg/g/ ST5/suppression of tumorigenicity 5 1064/2/rs3755551/1481764/[a/g]/aacgtctgggtatttgggcaaggagagacgcaggtgtacagtgaagtgc 20 accataggaag[a/g]cttgttaacgtagaacacgcaacatgctataccctgaagcacctgccatcaattccttaa/g/T PO/thyroid peroxidase 1065/9/rs10759021/8931696/[g/a]/taaaaatattatatttcacaaagttaaaacaactttgagagaaagctg tcagtgagttaa[a/g]gtggctgaaacagatctcacaaaaatccagcaaaaatacgactttcatcaagggctttta/g/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 1066/13/rs4238186/18588836/[a/g]/agctgcagtctccaacactgtcaacaatagcatgagataaactgcag agccactacatac[a/g]caggctccagtgtaccacaggtgactcctccttctcctcctccagcctggcttggagcag/a /DKFZp686A1627/putative PHD finger protein 2 pseudogene 1067/22/rs11703808/30354980/[g/a]/ggtggcagttctaaaacaggaacccaaacttgcgcggagtgaccgg ccctgtgaatagga[a/g]acaatggctgataggaccgtatagggggtaggggaacacctttgtcaggacatgctgttt/ 30 g/PISD/phosphatidylserine decarboxylase 1068/10/rs1412444/90992907/[a/g]/gctctttactgtccttcactcctattcaagagcaaggttgttgccac tggtgttatttcc[a/g]gtgtttaaaggcaaatagataaaaagaatggagaaggcctttcacacccaaagtgaaacg/g /LIPA/lipase A 1069/10/rs7083570/68806813/[g/a]/tataaattcaagattatttggcttatatttaaaatgaaaaaggcatg tttgcattccagt[g/a]cacagataaaagtgctctcttcctctagggatgaatatatcctaaccagtttaacatact/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1070/15/rs2053423/64813271/[c/t]/ctggattcaaagacctggtgaggtcccatcccgcttgggcactgatg ttcacataaactg[c/t]aggatgggagatttggaggagagccgagtccttgtcatggggaatcctttcctcatttta/t /SMAD6/SMAD family member 6 40 1071/10/rs2271469/17034053/[a/c]/gttgtaggtgtgttgtgttgttgtgcgtgtgtgtgttttttaacctt tgctaggccttga[c/a]atgaaaaaaaagaaattgtttttaaatttagaagcaactgtagaaatgacttccctatca/c /CUBN/cubilin (intrinsic factor-cobalamin receptor)/ 1072/19/rs350844/4128051/[a/g]/ataccctctgggtctctgggacatcggattcgacccccaaccccctctg gcagagccccc[g/a]cccctgcacccaggtggcactcacgtcttacacttggcacattcttccacaaacatgttc/a/S IRT6/sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevis iae)/ 1073/18/rs421436/38180576/[g/t]/tgtgaatattaaacaatggcattattaaaggctatccagtgctagctc ctaatatggaag[g/t]tattgagaagaatgtgtcattctatgtctgggaaaacaccaaagcaaaatctggaagcca/g/ LOC284260/hypothetical gene supported by BC011527; BC021928; BC011527; BC021928/ 50 (106) JP 2010-88432 A 2010.4.22 1074/10/rs1755153/14382622/[a/g]/ctgggtctgtagtggcaaccaaggcagggttggtccctactttcatg ggatgtataatct[g/a]aatgaggaagatgaacattaaagtaatatttaacaggtcattgatgtaaaatggtgaaag/a /FRMD4A/FERM domain containing 4A/ 1075/1/rs2818747/215155207/[a/g]/attctgtggttactagttacccaggaagcttctggctcaccactgtg tggggcaacttga[a/g]gaagacaaagaagatacataaagcagcaaggtcaccactgctctgcatctgaaaggatgc/a /ESRRG/estrogen-related receptor gamma/ 1076/7/rs156675/131844848/[c/t]/ctattgtagccacattttatagctaaggaaagcaagcttagggaagtc atgtaacttgca[t/c]agctataagtggtagaggtagctccaaatatgagtagtgtaaatgtgcacaggttcgcaa/t/ PLXNA4/plexin A4/ 1077/1/rs1341511/64263481/[g/a]/gagctcacattatacgacttctagaggtcattcaacttggagattccc 10 tgagtctaggtt[a/g]tggagaaaagttgtctctggcaccagactaatctgctgcccttcctaggggtggaaatat/a/ ROR1/receptor tyrosine kinase-like orphan receptor 1/ 1078/13/rs7997510/50921534/[a/g]/ctttcccgcaaacttttggtaagccttatagacaagaactaaagtgt tctctgggggcag[a/g]tatcaactgggaaaaggaaaatacaggtttaaattacaaatgtcctcagcctctccatga/g /INTS6/integrator complex subunit 6/ 1079/8/rs4557727/1581714/[a/g]/tattgtgggtgtgtctgagagggtgactctggatgaggttagcatttgg aggggtggacg[a/g]ggtgaagcagatgctttccccagtgtgggtgggccacgtcctatctagtggaagaaacaa/g/D LGAP2/"discs, large (Drosophila) homolog-associated protein 2"/ 1080/5/rs423834/115839119/[a/g]/atagagcgtggcaatacagatggtctgggggactgtcacagtaagtac agtcttttatcc[g/a]tttttatctttgggcaaagatgctttcagtgaatggcctagaaacatcagctcacatgtg/g/ 20 SEMA6A/"sema domain, transmembrane domain (TM), and cytoplasmic domain, (semapho rin) 6A"/ 1081/4/rs2292082/167215797/[g/a]/aaattctgtgtaatgtccaaagatccaaggcagatgactggatctgt acttcgcacatag[a/g]tggcattagagtagctttgtatagcagacatagtagctgctaggataccatctggtagcc/a /TLL1/tolloid-like 1/ 1082/20/rs244120/42629119/[a/g]/cttctggtttccattactcaatctgtcaggattctcaggtgctactaa caataagtgtct[a/g]ctccagctggtttaagcagaaaagcatttcttaaaaaaaagtagggatcttacagaatct/g/ PKIG/"protein kinase (cAMP-dependent, catalytic) inhibitor gamma"/ 1083/11/rs871437/132309082/[c/t]/gtctcagttattggtccaccttgactatccactgttgcctcctggtc attgtttggaacc[c/t]cctgtgatggagaaaaaaaggagtcaccatctgtacacccagggaattgaatgagtcagg/t 30 /OPCML/opioid binding protein/cell adhesion molecule-like 1084/10/rs786870/26814700/[a/g]/caaaatccagctgtcatgctaacactttaatggtatcttcattcccag cagagatttgct[a/g]tctactgcacttggtaaacatgtcagtaaatcctggccttaacaaccaacttgacatggt/g/ APBB1IP/"amyloid beta (A4) precursor protein-binding, family B, member 1 interac ting protein"/ 1085/2/rs6752599/109140121/[t/c]/cagaggggatcatagtattgactggggatattcaccgtctcttctac tcctcagctctgc[c/t]ggtaggtctagttttaaacttgcagtcaggccagcagagagcccgcattcctgtctccta/c /SH3MD4/SH3 multiple domains 4/ 1086/9/rs4740427/133141684/[t/g]/gtttaatgaataattatgcggttctgacatccagcccttctgtgcct cacacgcggggac[g/t]gcagctcgcagactctccctgaagtcttcggaggaagcaggcgagcgccggcagactcat/t 40 /FAM78A/"family with sequence similarity 78, member A"/ 1087/9/rs10793992/133139159/[a/g]/agagcagtaaagggacttgcctagggccacatcctggagagtggca gaacctggcctccc[g/a]cccagatctgcctaagaaggcatgaggctcttccaaccaggaagccaggactgcgacagg/ a/FAM78A/"family with sequence similarity 78, member A"/ 1088/9/rs920901/74419068/[g/a]/ggagtggccttgaagagatgcttaacttttggaaatcacttctttattg caaccaaagct[a/g]ttaagtttaaaggtccataaagatgagataaacagtcataaaggccttttgaaattcata/g/T MC1/transmembrane channel-like 1/ 1089/9/rs7029452/74397149/[g/a]/tcattaaagccaggaacttatcaatggcatcagtcagttctcttttct tttactcttatc[a/g]ttggtgtcaaagctctggcctctttttgttggttccactcaggtgccgtgatcctccagc/g/ TMC1/transmembrane channel-like 1/ 50 (107) JP 2010-88432 A 2010.4.22 1090/8/rs625218/9951252/[t/c]/caagatggaccaaaatttactttggctttatcttaaccaaagtcttccca atcagtttcc[c/t]aatatgtaaatgacatttttggtaaaagatgagcaaacatttcagaaatgagccaacaat/t/MS RA/methionine sulfoxide reductase A/ 1091/17/rs715662/2817655/[g/a]/aatcaatgccccaggaagcccagcaagctcaaatgtggctctcccagat ggaaagctagt[a/g]ggtagggtggtgacgagaagccgtaccccagctcggaagttgggcagtcacatcatgtac/g/G ARNL4/GTPase activating Rap/RanGAP domain-like 4 1092/15/rs220030/22750861/[g/a]/aatcctaatttacactcaccctcaggtcttcctatgtgcggtac[a/g ]aaaaagctggtttggaaaagttaaatgcgccataaccacaatcaatgcaaatacgccaga/a/LOC647795/hypoth etical protein LOC647795/ 1093/6/rs9481945/119960123/[a/g]/tacaagcatacattgtgtagtaatcaaatctgggtaattgggacatc 10 cattatcttaaac[a/g]tttgtgatgagaacatcccaaatctacttttctagctattctaaaatatacaatacattt/g /LOC728727/hypothetical protein LOC728727/ 1094/19/rs12611226/53162033/[a/g]/gggataagcctagggctcaagagaccaggcatttcatttctttctt tctttttttgactc[g/a]atggatgtttaatgatttaaaatttaatttaacttaattttagattcaggggatacgtgt/ a/BSPH1/bovine seminal plasma protein-like 1/ 1095/14/rs178159/26106958/[g/a]/gtatcacacagtaaatatcaagaaactcttcagatgttttaaatacag gcagaaatgact[g/a]taatattggttaagctttgtaaaggtgcagcagttcagagagctttgttgataaccaaat/a/ NOVA1/neuro-oncological ventral antigen 1/ 1096/11/rs10834425/24656588/[a/g]/tccttgtatagcatttccttagtctctcccttttgctgtattccca gtgtgcttgttata[a/g]gtgtcctaaatcaaatatttaatttgacactctgaattaaacacctgtgaaaagaaggaa/ 20 g/LUZP2/leucine zipper protein 2/ 1097/2/rs1434095/178962576/[t/c]/gttgtcattttctgaagacacttgatgtagtcatgtagatgatcacc accagtcagtaca[c/t]gcttatccaaccctgccactgttataattcaaataagttcaacaggaaaaattagcctca/c /OSBPL6/oxysterol binding protein-like 6/ 1098/5/rs791077/127014256/[t/c]/aaatattattcccctacaaatcttttagaaattctgtgtattattcta gtgaacagtaac[c/t]tgcattcaggatatacacacaaagatacaaaatatttcatataaattcaaagaattcatg/c/ CTXN3/cortexin 3/ 1099/17/rs8072920/62116510/[g/a]/gtgaatctttctcttcttcagacttgttagaattccctggaatttcc ccgctctagagca[g/a]tacacgtgcacacgcacacatgtgtgtagatgctgaactgctactgaaatgttgacacta/a /PRKCA/"protein kinase C, alpha"/ 30 1100/15/rs3098198/48607496/[g/a]/ttagttcttacctctgatgaatcttcaatttgcagcaaattctaaac acagttctctttc[g/a]aaaccaacttttgaccccttaattaaccaataatagtttgattactaaaagaactaagtt/g /USP50/ubiquitin specific peptidase 50/ 1101/7/rs4588783/102827171/[t/c]/aaggttctaatgccatgtagacaagactgaggaaaagaaaaggtttg aaggtattgcttc[c/t]ttgtgagctacgccagccagttgtttccacagctagaacttgttgttataatttggatca/c /SLC26A5/"solute carrier family 26, member 5 (prestin)"/ 1102/8/rs3779925/134608468/[t/c]/gacaagaaaacagagggtcagagaggtgaggagacttgcccaagctc acctgatccctga[c/t]ctgactgattgaaggcccagggcacccatccatgctaactaaggtgcaagttcgtactgt/c /ST3GAL1/"ST3 beta-galactoside alpha-2,3-sialyltransferase 1"/ 1103/14/rs2144834/93843387/[t/c]/ctcccagttgtgtgactttgggggaattcctcaacctctcttaagtg 40 ttggtctctcaac[c/t]tggaaattaaagatgttgattccgacttcataggtgcgtatgtgtgtgtgtgcacatgca/c /SERPINA6/"serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitryp sin), member 6"/ 1104/14/rs10498639/93845279/[g/a]/ttctcctcctggctactgcctcttcaggatatgcagcccttgcttt ctttctacttactc[g/a]cttattacctactttagccttgctttcttagttgtttactgatgattgattgattgaaga/ a/SERPINA6/"serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitry psin), member 6"/ 1105/18/rs9952185/59590623/[g/a]/aatataggtagaggttttaaagctcccatttacaaacccaacaataa ttttaaaggataa[a/g]aaaatagaggcttgtaggaaaattagatacatcatttatatttaactttgccactgaaac/a /SERPINB7/"serpin peptidase inhibitor, clade B (ovalbumin), member 7"/ 50 (108) JP 2010-88432 A 2010.4.22 1106/7/rs13244715/107788073/[a/g]/taattaactgctgaaaattaacagccctgaaaaagaggcacaggta cattcaaatgaagg[a/g]gcaggaataaatacaaatgaacatgacccggggttgcagggtgggggatataagagaaaa/ a/NRCAM/neuronal cell adhesion molecule/ 1107/7/rs1880738/48256031/[c/t]/aatgttactccttcccactcttattaatcttttagatgttggcgaaga atgctgtctgcc[c/t]gaatggtcgtttctctgagaaggaggtctttttgccgcctggaaactccagcatatgggg/c/ ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13"/ 1108/3/rs12108065/17049875/[a/g]/agtgttcaggcagacttatatgacgccaaaaccatgctttgaacgtg gcagaaactgaga[a/g]tttaacttagacttcaaataaaattccatagaagaattttgtaaacaaattttttggaaa/a /PLCL2/phospholipase C-like 2/ 1109/10/rs5003944/87880306/[g/a]/cagtagagaaggagaggagagaaggagcatctgaatgtcgagaggag 10 ttcggttggagac[a/g]gtcagagagaagatcagctgcaggatggtagaattccaggggaatatagtcttcccactc/g /GRID1/"glutamate receptor, ionotropic, delta 1"/ 1110/2/rs502059/234402914/[g/a]/gtgatccctgccaaaggagagactacaccctgacggaatgatccagaa ggctctgcaggg[a/g]ccaaggcattgggtattccttggagaatggctggggttttgctgggcttcctgctgcctg/a/ LOC339766/hypothetical protein LOC339766/ 1111/5/rs257699/66170467/[g/a]/acagttgataaaatatttctatgccctgattacagtctttcaatggctt cctattgctag[g/a]ctatgaggcccaaatccctgaacacagacagcatcattcttgagactctgctaaacactt/a/M AST4/microtubule associated serine/threonine kinase family member 4 1112/15/rs2249378/22933834/[t/c]/cacagatacagtatgaagtgtgtggctgggacacagcaagaccacaa taaagggtaacga[c/t]gggacaggattatcacatttacttctgtgcctgtcattcagtacagaacataaatcagcc/c 20 /PAR1/Prader-Willi/Angelman region-1 1113/19/rs2873409/2559353/[c/t]/ctccagagacgatctctgtcctcccgtgtgtgtgaagagcccgtccct ccagcccgcagg[c/t]cttgccttgcaggggcttcggggactttttttttttttcccaggggcaaatcccacgtgg/t/ GNG7/"guanine nucleotide binding protein (G protein), gamma 7"/ 1114/19/rs8107385/43324592/[g/t]/tcctggaggaggcagggaaatgggaagtggggaagcccacaggtaga tgttagcaccacc[g/t]ttctagtcctggggttggctggtagcttcagggagtttgttttatgatgatgacaaatat/t /SIPA1L3/signal-induced proliferation-associated 1 like 3/ 1115/3/rs2239625/187485434/[a/c]/taggttgtgttctagtgacgctgaaatgtgttcatgctccccaggga attacactcatga[c/a]ctggacttcatcagccacataggtattgcttagacaggtccagaagccaggtggttctcc/a /DGKG/"diacylglycerol kinase, gamma 90kDa"/ 30 1116/11/rs10219167/12360412/[g/a]/tcacgcacagttcttgtgtgtatgtgtacattttgacatttcgata agttctaactgttt[g/a]taatagatttgtttatattttatggtagtaaatgagaaggcagacaagtattgatgtata/ g/PARVA/"parvin, alpha"/ 1117/17/rs7222081/28434385/[c/t]/ataagcaaggcactggggccacagaatccaaaagacacaatccttgc tctcagagggctc[t/c]gagactataagagacaagggctgagagaggcaaaagaaggcagttctggagaggtaggtg/c /ACCN1/"amiloride-sensitive cation channel 1, neuronal"/ 1118/5/rs1910092/13834480/[t/c]/tttttcttcccttcaatttaaatttgaacacttttcaaatgtggagga tattctcatcaa[t/c]gacgatgccctgtatgccaagggtagacattgttctgacatttctgttctccttcctgtc/c/ DNAH5/"dynein, axonemal, heavy chain 5"/ 1119/6/rs1890100/152679902/[t/c]/ggaaacgatcttttgataccattgaatatcataggtattataatgat 40 caacccctaagac[c/t]gttgtgtccaaagagagagaagactgatttatagctcaagaaactgaggagtttacattt/c /SYNE1/"spectrin repeat containing, nuclear envelope 1" 1120/7/rs4298437/103413113/[t/c]/aaattctagtccattcagaaatttaggtacattgtctcaccaaagct caagtattttggg[c/t]agactcatttacttaacgcttgtctttcatgcacaatgtcttcttctaatggctgacctc/c /RELN/reelin 1121/8/rs4738353/74509416/[t/c]/cattttatctctctgagcctctttttcatcatttgtaagctgaaggct acgtgactgcac[c/t]ggattatctgagaggtgaatgccttgaccatagtggtgtttaataaatgagggctttcat/c/ LOC100128126/hypothetical protein LOC100128126 1122/12/rs2734562/10455596/[g/a]/acaccctagcagctcagtctcttatattctgaggtgtatgatgagat aaactgattcaaa[g/a]tggccctagtgtgaaaacttcctgttcaaatccgaagtgatacattgatgaggaatctgc/a 50 (109) JP 2010-88432 A 2010.4.22 /KLRC3/"killer cell lectin-like receptor subfamily C, member 3" 1123/12/rs7978668/69325443/[c/t]/gagagaatccacaaaactcttggcacagtaactgcccttcagtgagt actaaataaatgc[t/c]gtgtattatttttcttattcttagttaatacgacacctagggtaaccatgtttggaagag/t /PTPRR/"protein tyrosine phosphatase, receptor type, R" 1124/17/rs6502579/17159584/[c/t]/aatgggaagctggctctagggagctgagaattgacatcagacctgaa gagtaagaatgaa[t/c]gggccagtgaagagtcgggacaggccttgcaggccaggagaggagcaggtgccaatgcct/t /NT5M/5' 1125/20/rs596720/3545874/[t/c]/gttggcaaccaagaatctgttatctcagtctacacagcgtggagttaga agattggattg[t/c]tgttggttagaattttgtccagagagttagaagatagaagaaaagggagggctgaggaca/c/A TRN/attractin 10 1126/9/rs1986633/20866259/[c/t]/aagaactttggataactgaaggctttttccttccttggactcatgtta acttcagggagg[c/t]cttagactctgaaaagctaagaggtaggaagtggggaagaacagaagagaggaagagtga/c/ KIAA1797/KIAA1797 1127/22/rs1569488/35295230/[c/t]/tcggtgttgggtcttgagcaggtacctaacatatatgatataatttc atcctcataacag[c/t]ccggcagggtgtgtttttttgccccaatttacagacaagaaaattgaggttcagagagag/c /CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 1128/8/rs12545907/40545260/[g/a]/ggcattttcataattttgggatagaagtattgagggttacacctcaa cattcatctaccc[a/g]ttcctcggggcccatttagtacttattattattattgttgttgcttttgttcttaaaact/g /ZMAT4/"zinc finger, matrin type 4" 1129/2/rs10432443/212344786/[t/c]/gagactaggggctacgatcagttcataccatgcatgaggtgctggc 20 cgaatctcttggtg[c/t]tcttatagagaaaaatgataagcaacggaactggcctcagcctaccattacctttacagg/ t/ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 1130/1/rs10799902/161426306/[a/g]/gaaacaggagtctcatgcaccgtggtaccaaaacccactggtaaag tcctcacttaagct[a/g]caatgaaattgagagaacagaaaaacttgagatttgatagaatttgaaatttgatagtta/ a/RGS5/regulator of G-protein signaling 5 1131/1/rs10779261/214661929/[c/t]/tcagctttggagaaggaggagaagaaaagcagctcttgtgatttcc aaaaataaaacttg[c/t]agaattgctatgggcgttaggatgcagatcattcttgtctggtgtgatgcagctactgag/ c/USH2A/"Usher syndrome 2A (autosomal recessive, mild)" 1132/14/rs10483756/62357755/[t/c]/aataacaggtacatgataatgatttctataattaaatatagggtac attatcttaactaa[c/t]tttgtatcaatgctattgataagacttgaaaacagaacagtaaacactgctagttgttta/ 30 t/KCNH5/"potassium voltage-gated channel, subfamily H (eag-related), member 5" 1133/1/rs2223286/167932256/[c/t]/aaactactatggggttaatgtgtctagctagagcaggaagtaactta aggaagtagagaa[c/t]gaatcagcagatgtggaaactcctcgccactaataaaacttaccttctcttggatttctt/c /SELL/selectin L (lymphocyte adhesion molecule 1) 1134/11/rs11035719/40137148/[c/a]/ttcttatcttaaaataatctaaatcttattgagcatgataggatta agtgggaattggac[a/c]gatagtggagttggggatggattgtaattatactacactgcgaaaaagcaaagtgcacat/ c/LRRC4C/leucine rich repeat containing 4C 1135/11/rs4304785/132754470/[t/c]/gtcttctacacccctgtgcgtctgatcatttatttctgcctctgca ttcatcctctcagc[c/t]gagctctttagagagctccctctgcggccacacccatttcttcagcacttcatttatttg/ t/OPCML/opioid binding protein/cell adhesion molecule-like 40 1136/14/rs8003511/101370279/[t/c]/ctcttcctctgggtggcaaatgtgatccattcaagacagattatat cccatgtgaagagt[c/t]accctgagaatttgagcagggtgtgctgtgtggttacttggactccagacccttgtctgc/ t/PPP2R5C/"protein phosphatase 2, regulatory subunit B', gamma isoform"/ 1137/21/rs11910494/32217984/[g/a]/cccaccgtacctcttatgacaagttgattgtaggggcaatggccca ggaggagcttcctg[a/g]gggtagtagaaatgtgatcctgagtaacaacaaaggttgggtcctgacagtgggggccaa/ g/HUNK/hormonally upregulated Neu-associated kinase/ 1138/17/rs2240568/12823738/[a/g]/gcctgagcacctctaccgtatcctgccatcaacccaggaattctaga acattctcaaact[g/a]gaacaccaaagtgcttttcctactgtagccaagaggacttctcagggccactgtgcccaa/g /RICH2/Rho-type GTPase-activating protein RICH2/ 1139/9/rs3128606/136762744/[t/c]/ctgacagttcctgtctctgggggctgtgaagttttcagattcaggag 50 (110) JP 2010-88432 A 2010.4.22 gagccttgcgtag[c/t]gtgtagcacatggccgatgcttaacatagccactgtgtgatgcagaatctccactgccag/c /COL5A1/"collagen, type V, alpha 1"/ 1140/9/rs3124300/136759683/[a/g]/agttcttcctatcacctctgcatgaaaatgctctcccactccctggg cccactgcctctc[a/g]tttctcatccgtaatattaaatcctgtttatttctccttgggtcttccttctttcaccac/g /COL5A1/"collagen, type V, alpha 1"/ 1141/8/rs4841336/6442687/[t/c]/tcgtctctgggaacatttccttcaacagagtcctgcttttctcatcctc acacctcactg[c/t]gcccctcctgaacccactcctttctgaatatggtctactgtccttccgtgacccacatca/c/M CPH1/microcephalin 1/ 1142/8/rs2922859/6428786/[c/a]/tgcaaaatttagaacagaaggtaggtacaaaatgccaaagatatgtctt aaaaaaaaaaa[a/c]aaaacaagaaatgaacaccaataacctaggaaaaaaaaaaaaagactccgagaccatgag/a/M 10 CPH1/microcephalin 1/ 1143/5/rs12520877/16831415/[g/a]/gctcgatgactgggctatcttaaatgcagataccttgtaacaaagcc cttgcaagagacc[a/g]tggcatgccacaatgcagagacaggatgactaatgctcacgcaaccagaaatggccatca/a /MYO10/myosin X/ 1144/3/rs9831813/129961232/[a/g]/ttacaacaccccatggtacctgaacctcaagtaagctctgttaggtt ttcatatctgccc[g/a]tgtatgatggtgactttttttttttctgagacggagtttcgctcttgttacccaggctgg/g /RAB7A/RAB7A/ 1145/3/rs6780207/129935499/[t/c]/agcagtatataagaagtccaaatattccacatccttgctagcacttg taactttttctct[c/t]taattttagttccctctggtagaaagccatttctttatggcaccatggtacagcttgttt/c /RAB7A/RAB7A/ 20 1146/3/rs11130199/49513803/[t/c]/ggatctaataagtgaagtaaagactaaagatgatgggaagaacctga aaaaaaggtcctg[t/c]gtctccccattcattcattaggtgtatggtgtatgtctggcactggatgagtgctgggca/c /DAG1/dystroglycan 1 (dystrophin-associated glycoprotein 1)/ 1147/3/rs3924462/49499240/[a/c]/atatctaacagttcactcttaggtatatacccagaagacaccgtcaag aatattcatatc[c/a]ggctgagcgcagtgtctcacgcctgtaatcccaacactttgggaggctgaggtgggcaga/c/ DAG1/dystroglycan 1 (dystrophin-associated glycoprotein 1)/ 1148/16/rs10500356/7399615/[t/c]/cagtgtatgtctgtgcattgaatatgtatgtgtgcgtaatacatatt acgttcgtttgga[t/c]ggtcttaataaggagccacataccatcagatgtaatccaatcactataggccagaccttc/t /A2BP1/ataxin 2-binding protein 1/ 1149/2/rs2120853/241729091/[a/g]/aagcaaccttcctgcctcagccttccaaagaactgggattataggca 30 cgcctggctttga[a/g]tgtaatttagacacagaagtgttgatcttatgctgtttgtgcttccgagtggacctggtg/a /PASK/PAS domain containing serine/threonine kinase 1150/8/rs6980953/1569246/[t/c]/aatatcactgcctaatattttactgcctaatatgttattatttctataa cacgatgaata[c/t]acatggcctagagaaacccataaaacacagcaagcaataaaagctcgaggcgccgcacat/t/D LGAP2/"discs, large (Drosophila) homolog-associated protein 2"/ 1151/5/rs2292011/134707146/[t/c]/aaacacagacccactcccctgccacggtatatcttcctgggccctcc aatgccctgtgtc[c/t]gaggagttccacagctgtctgctgcgttgtgattccaacgtgagctggagccaagccaca/t /H2AFY/"H2A histone family, member Y" 1152/10/rs10997565/68625276/[a/g]/acacctaccatacaggactttacttaatgtagctttataacatgtt ttaatatcgggggc[g/a]gggggcgggtaggctccacctcagtggtctccttgctaatgttattttttgcatttaaat/ 40 g/CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1153/10/rs4746673/68605706/[g/a]/taattgatttcctgaagatcattcctttttcacagggcctcgttgct ctgccccatttat[a/g]aaaaaattccttaattatgttatacatcagagaagatgaactaggtctaaccagtcatag/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1154/10/rs7073720/68552611/[g/t]/taagaaaaggcaatgtgagttacaggagcatcggtctgatgaggcca tatacaggatatc[t/g]taccatcaatattcctacctaatgtgtcagaattgtacagctcttttttaaaaagccaca/t /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1155/4/rs6848061/79292674/[t/g]/agagactaatgtacttgctgattttaaatcggtacaggctttaattca gacctaattgct[g/t]catcaagttgtgtacatgtatttcctccccaactagaggcaaacattttcaattcaagaa/g/ FRAS1/Fraser syndrome 1 50 (111) JP 2010-88432 A 2010.4.22 1156/4/rs10025977/79260003/[c/t]/tgagttttacttttaacaagtgtcccaggtgattctgatactggtcc atggaccagtgta[t/c]gggaaactccactttggagaacattactaaacaagcaaaacctcttgactcacagctggt/t /FRAS1/Fraser syndrome 1 1157/4/rs10033428/79259915/[t/g]/accttatagtttattagggaatttatcaaaaactctgccacgtaaca cagttctgaggat[g/t]ctaattcagcgagatgagggaggatcctgagttttacttttaacaagtgtcccaggtgat/g /FRAS1/Fraser syndrome 1 1158/9/rs713066/99110631/[c/t]/cagttatgggagtcctaggtcaacaagtggggagctgctcagtatggtg aaatacatggg[c/t]gcccacgggcatagaaaagggtctgtgagatactgttatgaagaaaaagcagatttcaaa/t/K IAA1529/KIAA1529 1159/17/rs7209079/28618872/[c/t]/aggagagatgagcgtgggcttggaaagctgcacaggcatcttgcagg 10 aggtaggaagtga[c/t]ggtgctccggggagggacaggatacccagaagtggaggggacgggagagtgtggggtgag/t /ACCN1/"amiloride-sensitive cation channel 1, neuronal" 1160/3/rs1372071/16955590/[c/a]/aaatattactgtgaatccatgctgtatgttttggcttcctgaaaatca actaaggcccat[a/c]catgctgtgcagatgttgaaagtacaattctccctgtagatagcaaagggtaagcgggta/c/ PLCL2/phospholipase C-like 2 1161/3/rs7627367/41586232/[g/t]/atattgccttttacaccgtgtcctctctcttgttgatcagactcacca aagcttgatcta[t/g]gctatcagacttttcaaggaaccacctttccatttgaatgactaccctacattttttttt/g/ ULK4/unc-51-like kinase 4 (C. elegans) 1162/11/rs2186775/70966737/[g/a]/tcacatacacacattcaaacagaaacaaccccccatacaccctccac acactcctctagt[g/a]tctgggggcttcagactctcacagcttgaagaggagacacgcatctctgctgagcgagcc/g 20 /LOC727727/hypothetical LOC727727 1163/15/rs1455780/90786010/[c/t]/tctgcctcaatttcctcactgcaaagccaggataaaaacagagtgct ccatacagaatag[t/c]tgtgataattaaataagttaataaacatgaagtacatagaatagcacctggtacgttcaa/t /ST8SIA2/"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2" 1164/12/rs10505933/24129457/[c/t]/aagaggggcaacagatgcctttcagcctgttcaccctgaattcatc ccctcaatggaata[c/t]ctttgggccatctgaaaactacacaatgtaatgtgggctcatgccagggactctgctata/ t/SOX5/SRY (sex determining region Y)-box 5 1165/4/rs2276883/83821174/[g/a]/gaggttgagggactgtgggttgaagacaggaggaaagtgaaaccagca gtgaggactggt[a/g]ggggaggggaggctgggaagcttcccaggaggatgctcggcggtgcggttcctctcttca/a/ SCD5/stearoyl-CoA desaturase 5 30 1166/2/rs935471/134741236/[g/a]/attccctaacaagtagattcagggggagcaagtcagagatgcttgctg gtggacaggtcc[a/g]ttgtagttcttaagaggtggtgaagcatggtgggtaagagccatcagccctggaaccaga/a/ MGAT5/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransfer ase" 1167/2/rs10469554/133697527/[g/a]/ggccatgacaatgtcgagtgccaggtgcacctgtcgtgtgggcaga tggggagaccagcg[a/g]cggcagtccctgagtaatggttaagttaattagcctttccatggcagatcatttaattac/ a/NAP5/Nck-associated protein 5 1168/13/rs1408165/42366368/[t/c]/atcagatagaaatctgtaaattggtcacaatacaacaaaataatcaa gtgcttgctgacc[c/t]agaaaatctagagaagatcttcctttaataaatacttgacagacaaaagatcatgtttga/c /EPSTI1/epithelial stromal interaction 1 (breast) 40 1169/12/rs1377003/43218535/[a/g]/tcagtggctcttgattgttcacagaaaaaaaagacattctttcacct aaatccgtcttac[a/g]aaattgtattttcctctgtgtaatcaaatgatgaatgtgaacgtgtgttgtaaactctga/g /NELL2/NEL-like 2 (chicken) 1170/4/rs2928297/37133996/[a/g]/tagctaggtttcctctccctagactgtgtttcacattcccctagttac acaatttttctg[a/g]taaccctgaatcttgggatcttttacagtcttggttaaatagtaactagtacctatgtcc/g/ C4orf19/chromosome 4 open reading frame 19 1171/3/rs9856750/179854048/[g/a]/cttaaagtatctccattaagtacgatgtttgctctagccttttgata tgtagcttctata[g/a]agttaaacaaggcctggccctccaggaaatttttagaaaccataaatcttcatcaagtgt/a /KCNMB2/"potassium large conductance calcium-activated channel, subfamily M, bet a member 2" 50 (112) JP 2010-88432 A 2010.4.22 1172/3/rs9822911/87401448/[c/t]/aaaaaaaaatttcaaatttcaaaaaatgaaaagatgggttccaaaaat agactagactat[t/c]tctccctgtcagttgccaggctgatttccgttttcttctgtattagcccaggcagcaaga/t/ POU1F1/POU class 1 homeobox 1 1173/9/rs8114/70586059/[a/g]/taagtcaacatttatattttcatcagaacttaataatcccataaataaata gagctctca[a/g]ttatttaaaaaaatcaagggataacatatgtatttagacatattagcagcgtaaagatgt/a/FAM 122A/family with sequence similarity 122A 1174/9/rs1986632/20866513/[t/g]/cttccccttctttctcagtcgaaggcactgagaaccaccaaggacaaa caatgtagaaga[g/t]ccaggtaatagccatcatagcactgcacattctgtactgagaggacaaacaacagcaccc/t/ KIAA1797/KIAA1797 1175/18/rs7505930/4082001/[t/c]/atcacaaatatcaaggataggacagtatgggctaagataaatagtatc 10 tatgtctggaaa[c/t]ggcacacttcttttagtaggcctacagtgctggagttggtcaatctagttagaagttgag/t/ LOC388458/hypothetical gene supported by BC040718 1176/13/rs1359186/42363831/[t/c]/actggaacttaccacacacacaaggaaacaagtggttgtgattcaac atcacaaacacaa[c/t]agaaagacttagagccagatgatttcacatgctaaaatgattagatactgaatttaaaat/c /EPSTI1/epithelial stromal interaction 1 (breast) 1177/1/rs212540/21465704/[g/a]/cccatctcagaggaagcagttcactttctcaggaaggcttagaagtcca gcatgctaccc[a/g]ctagctctgccttgataggccagtttcttcacgcacctgggcctcattttccttgtctct/a/E CE1/endothelin converting enzyme 1 1178/6/rs393034/42776609/[t/c]/tgtccattaaaggccccaagtaaaaggggcatttgaatgccctcttccc aataagctgat[t/c]cttgtctaatgcagtccactagattcctgtaaaggtggggccactaagaggctgccaatg/c/P 20 RPH2/"peripherin 2 (retinal degeneration, slow)" 1179/6/rs324356/155648017/[c/t]/tactacaacaaataagcagaaacttacctctggtttggggacaaaagc ttgtcctggaat[c/t]gtaaagatgtgtcgaacattgcagaggtactgagccataacagagaggcgactacgctgt/t/ TFB1M/"transcription factor B1, mitochondrial" 1180/6/rs324360/155651442/[g/a]/attcaaaaaagatcttatttaagtatttaagtatatttcacttagaac acatccagaaac[a/g]tcaggggaatatgtgtcccaatccattaacctgacccattcaattcaatctttgtagcat/a/ TFB1M/"transcription factor B1, mitochondrial" 1181/11/rs1939472/95520632/[a/g]/caaaaacaatcccccttttaagacacaacacaggggtaccccaagtg catactttgctcc[a/g]aacaatacccctacaatgtgcatgtgatagattcggaaatcatactggagtgtaaaaaac/g /MAML2/mastermind-like 2 (Drosophila) 30 1182/14/rs6575340/93093725/[a/g]/agagaaaggaaaattctagacagaaaatcacaagctgcctgacataa cctaaacatttcc[g/a]ccctctgaatggtagagatggagagagagtacccccatatggtcacaaagacaatggagg/g /KIAA1409/KIAA1409 1183/14/rs6575354/93298589/[a/g]/caggcccactccagggaaaagggtccagctatcttctctgtgccctg tcctgttcccctg[g/a]gacaccacccatcagaaccaggctgactcagaagtacagtaggctcccatccggaaccca/a /PRIMA1/proline rich membrane anchor 1 1184/7/rs892729/157415670/[a/g]/agaggggtgtcttggggcacctggcaggttccagggtgggagctataa actagaagtccc[a/g]cgcttctcctcccccaggttcacttgaccacaattctaaaatattaatagcatacagcgt/g/ PTPRN2/"protein tyrosine phosphatase, receptor type, N polypeptide 2" 1185/9/rs1050700/134757764/[g/a]/gcacaggctggaggagggtttgggcagagcgaagacccggccaggac 40 cttggtgagatgg[a/g]gtgccgcccacctcctgcggatactcttggagagttgttcccccagggggctctgcccca/g /TSC1/tuberous sclerosis 1 1186/22/rs9614985/43699295/[a/g]/gaaccataagaaactgatttctgttgcttaagccagccagtccatgg tatttttgttatg[g/a]cagcctgggcagactaggacatttatgatacgagacagccattctattcctaagcattcg/a /PHF21B/PHD finger protein 21B 1187/14/rs1957316/33063269/[a/g]/catatgtatttgtctgtaaatttgttattctttttcttcctgctata ctatcggattttt[a/g]agaacaggaactagagctgttttattcaccaccctatcccagcaccttcaaaaagtccct/a /NPAS3/neuronal PAS domain protein 3 1188/14/rs7146310/23723794/[g/a]/cctgttaacaggaattcccgcaggtgctccatgatggcagggaagta gggcagcagcgag[g/a]cctgggcagccgtagctgcaggatggaaggacagaatcagagctggagagggcagggacc/g 50 (113) JP 2010-88432 A 2010.4.22 /IPO4/importin 4 1189/4/rs10030246/186778881/[t/c]/tccttctgccttactctcccctcttcgctcttcctctgtttttaaa tacttattgaatct[c/t]aagatgccatgctgtttatctacgaccttcctttgtgcccagatgataaacaccttatca/ t/SORBS2/sorbin and SH3 domain containing 2 1190/22/rs6518660/15955800/[g/a]/aattctcattctctttaatatttgcataatattccatagtagatagc aatctattcaacc[a/g]tttctagtttgatggacatttagatttaaactagatctcaccttaattcagccattctct/a /IL17RA/interleukin 17 receptor A 1191/9/rs883601/20732770/[t/c]/tagacctttaattatctgtaatgtttgaccttttaattcattttttcct atagttggttc[c/t]tttaacttcagtcttgtttcaaaaggcaattgctgcaaggtgtgaataggaagcctagtt/t/K IAA1797/KIAA1797 10 1192/7/rs7801657/70709832/[g/a]/actgatatattcaagaagccatatgcggtatgaatgcagtgtacagta aatctgaaagac[a/g]agggtagtgggggtggaaagtaaagctacacagtaatttggtggtcagaaacaaatggcc/g/ WBSCR17/Williams-Beuren syndrome chromosome region 17 1193/2/rs10183967/71650684/[c/a]/gcacctggtgctcagggacaggtggggcatgtttctctttgccccct cttacctccggag[a/c]cttcatgctttgatttccaaagggaaagtgtggggtgcagtggtggcaggacactgactc/c /DYSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)" 1194/15/rs1618332/39972086/[t/c]/tggtaaataattcagggcctctgtttcctcatctgtgaaatgaaaag cctaagagaacgc[c/t]aagattcttttggcctagaatcctgtgagtctctcttatgacagacagtgacattttcca/t /SPTBN5/"spectrin, beta, non-erythrocytic 5" 1195/2/rs10176201/97837810/[c/t]/gtctttgttcaaatgtcaccttctgaataaagcctaccctgaccacc 20 ctatttaaaatgg[t/c]accgccttccctgtgcacacctaagtctctgatcttatacttttcttctgaccttgtaac/t /TMEM131/transmembrane protein 131 1196/14/rs3848/33060427/[t/c]/tttttttttttttttttaaagcagatcatctctccaaatcatcacttcta tcaagcctat[t/c]gcttgagcagtgttatagcactcagccctcagggcaaagataagtcttcaccattgtcac/c/NP AS3/neuronal PAS domain protein 3 1197/16/rs8053158/85327410/[a/g]/gtggtgtcaacacagatgccaccttctcccccttgttttcagggact aggctttatttcc[a/g]accttggccttctcaaggagactagttgaaggcctgccatcctggagggacctggccagc/a /LOC729979/hypothetical protein LOC729979 1198/13/rs1077728/50708717/[t/c]/taagcaattacatttgtgataagccaatgtaggagctttgaaagcaa cacatggaaaaga[c/t]atgattgcatactgtagaactcctcaccaatgcggaatatgtgaatacatatgatctgtg/t 30 /FAM124A/family with sequence similarity 124A 1199/10/rs2394189/67507504/[g/a]/tcaaaggtggtgatctgtatggagcccctaaaacaagatgctgatgt gagcaggtatcaa[a/g]aaagctgacgtgaatatcctcatccttttgacagatgtgatcctagcacggccatatagt/g /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1200/6/rs2501968/49567937/[a/g]/ataattcatcacagatgaagagcatgtcaaccttcattgaagaagcct ataagaaactgg[a/g]tgcatcttaaagagtgttttttttttagattgttccatattaatttaatgttcgtgaatt/a/ CENPQ/centromere protein Q 1201/2/rs872288/45968529/[g/t]/cagttccagatatgatttca[g/t]ttgggccagttagatgtgcttttg tgaaatttagaacgccaaagtgaggcagagaccaca/g/PRKCE/"protein kinase C, epsilon" 1202/6/rs7769173/11332734/[a/c]/actggacttctgccccaggggagcacgcaagggaaagagggctcaaca 40 ttttgctaggcc[a/c]atgctgctgtggtagtgcgactgtaccacaggtccacgaacccatttcctgccaaactct/a/ NEDD9/"neural precursor cell expressed, developmentally down-regulated 9" 1203/12/rs4931593/32036123/[c/a]/ataggtgatgggtcattatgaaaaaaggacactgaagctaatgtaac actgaaatggtct[c/a]aagaaacaggaaactatagacatgttttagaatatccaatacatggcaagaccaaaatat/c /C12orf35/chromosome 12 open reading frame 35 1204/14/rs8017842/99125475/[a/g]/cgcagaacgctgttggattttactcgactctatgcctttgtgttctg tgtggagcttccc[a/g]accacgaacgtgcattcagttgtggagcttcccgaccacgaacgtgcattcggttgtgga/a /C14orf65/chromosome 14 open reading frame 65 1205/16/rs4315319/60283705/[t/c]/ttctcccatcagagatttttacctctgtctgtggttgcctgtgaacc tgaccactggata[t/c]ttcttttagtcactcttgctacgcgtcattattgcagtttgacgcatttcttcctgcaga/t 50 (114) JP 2010-88432 A 2010.4.22 /CDH8/cadherin 8 1206/12/rs2466453/116760315/[g/t]/tcaaaaacccaacccaaaacgttatgcatggtccattgtgctgact tttggggtctgttc[g/t]gcatcagactgagttctttggggagtggggaccacatctcgttgtctttggagtgctgta/ g/KSR2/kinase suppressor of ras 2 1207/10/rs1426618/90066695/[t/c]/agtgtgttttcagaagctaaagtctaaaaatacaaagagtcaagcag aatttaaacgtga[c/t]caaagtttgaaaatagagcagtataaaaagccacaaatatgttaataggatctagagcat/t /C10orf59/chromosome 10 open reading frame 59 1208/9/rs2589619/74489204/[t/c]/caaaacagaaaaaggagactcaaaatggtgaggaacaggagaagaaca aactgaagaaat[t/c]aaaaatgaacaatcagctcttaagtagaaggaaagtcagagattgtggatggcagaagat/t/ TMC1/transmembrane channel-like 1 10 1209/7/rs985409/103958659/[a/g]/acactttttctccatggcaggggcaaaatgctcttcgattgctctagt gggaagtgcttt[a/g]cagttatctcatttctaaaacaaaaatattgcctgtatttaaaaaataaataaagttctg/a/ LHFPL3/lipoma HMGIC fusion partner-like 3 1210/4/rs6535374/83818702/[a/g]/cagaaaatcttttgccttctcatctgaactcttcaaattaatctaagg tctgattgtccc[a/g]aagtattattaattatatagcaacatcatttgtatcacagaattggaaatgacatacata/g/ SCD5/stearoyl-CoA desaturase 5 1211/18/rs1380775/3657903/[t/c]/atatgccactgtggcataaaaatgattttgagctgaaggcatttgata agaggcttattt[c/t]taaactccttatctgccccaaagcagaacctcctcccaaaactcaattgtcataaatccc/c/ DLGAP1/"discs, large (Drosophila) homolog-associated protein 1" 1212/14/rs1957863/41372302/[t/c]/gtatcaagagattctatagaaggcggatgtggctagacctctctgat 20 tgaatccagagaa[t/c]gaagaaatttgtgccctctctgaatgctcatcacatagccacctcagcagaggatcctaa/c /LRFN5/leucine rich repeat and fibronectin type III domain containing 5 1213/14/rs1475244/41368513/[a/c]/tgaagtcattaagaaaataaccagattaattcagaaaaaaaagataa aaatcaagaggaa[a/c]acaaccattaatagacctggataatatggtttataatttacctcattcaagataaggtca/c /LRFN5/leucine rich repeat and fibronectin type III domain containing 5 1214/7/rs10488140/55105882/[t/c]/gggatgtgcgcaggcgattatttgcaaacggccctgagtcccccagt ttatgtcttaatt[c/t]gcagccagggctgattgtagaagcaaatttgcaaacatgtgcaagaagaaatcacacatc/c /EGFR/epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog 1215/6/rs3813331/139396851/[c/t]/ttgtcttgttcaggtcgcgtctgtcactattaatttaccatgttcct 30 tttcctaaaaata[t/c]ttgtgtgatgcatgtggcactgaagtgtccccattttccctctacctttgtaaccgcccc/t /C6orf115/chromosome 6 open reading frame 115/ 1216/3/rs12489516/150080302/[c/t]/atctcaagtttacttttaaatagattggggaaaagaatgaaagaag aaaggctattttta[c/t]ggattgtggcattcacgcacgagaatgggtctccccagcattctgccagtggtttgtcta/ t/CPA3/carboxypeptidase A3 (mast cell)/ 1217/1/rs4618970/205728263/[c/t]/agaaaaccttgggcaaggtctcagggtcaatcattggcaaaggtgga atgcaagctcatg[c/t]ctgagtttaaactgctttctcctacataatctagaaaataaagataccagccaggagtgg/t /CR2/complement component (3d/Epstein Barr virus) receptor 2 1218/19/rs4808737/17978646/[t/c]/ccgtctgcgaaatgaattgagggaggcgctggctcagtagtcccttc agggttacctaat[c/t]ccgcttctcctcccggacttaacggcctactgtctcccctctagtatccattgaaacctg/c 40 /ARRDC2/arrestin domain containing 2/ 1219/3/rs1016284/120188854/[a/g]/tgtgagggttatttcttgtgttcatcccagaggatgagaacacctct cctccaggaaatg[a/g]gtgaggacaaactgcctctcacacgacacccacatatattctaggtttagggacactggg/g /IGSF11/"immunoglobulin superfamily, member 11"/ 1220/5/rs4700720/179547251/[a/g]/acaaatttatacacctgtaagagtctagtattctgaacatataaata actcctataactt[a/g]aagaaaatacaaataacccaattttttaagaagcaggcaaaatacttgaatagacatttt/g /RASGEF1C/"RasGEF domain family, member 1C"/ 1221/7/rs2228006/5993301/[a/g]/gccagctccccaggggacaggggctcgcaggaacatgtggactctcagg agaaagcgcct[a/g]aaactgacgactctttttcagatgtggactgccattcaaaccaggaagataccggatgta/g/P MS2/PMS2 postmeiotic segregation increased 2 (S. cerevisiae)/ 50 (115) JP 2010-88432 A 2010.4.22 1222/6/rs7744222/145186074/[c/a]/acaagagaaaaaaaggaagaagtgtaagcttgcatcagatgcaccaa gatcctttttgga[a/c]agatttatgaactactagatatagtgggcaggttttctttttttaatcctagaccaagct/a /UTRN/utrophin/ 1223/1/rs303386/99361967/[t/c]/gcttagggaccatgaactaataagttcattaccgcacattatcttaagc acatgctatca[c/t]gctatttggtaactatgatactatttcaagttttaagggaaaattgctacaggggttact/c/L OC100129620/similar to hCG2028334/ 1224/9/rs4838298/127669309/[c/t]/caaatgatgcatttcaccctacattgatgtcgttaggaccattcacc atagatgtgtccc[c/t]ggtcctccctgaagtattaaaaaaaaaaaatcaattatttgaataaaagaatagaagcca/t /PBX3/pre-B-cell leukemia homeobox 3/ 1225/8/rs1031178/72387111/[a/g]/gatatcaacagttaagaatggctactcaaaacggagaatggcttagaa 10 ctgtcagacctc[a/g]ttgttgtacatacacctaaattacagagctcacaggagtggcttttaaagaaaactacaa/g/ EYA1/eyes absent homolog 1 (Drosophila)/ 1226/16/rs2545886/20936698/[g/a]/tgctcattcattatttcattattatgaaacataataatgtttcatta ttatcaaacatac[a/g]gaaacatggaagacattgtacagtgaacatttgtatactcaccttctagattttaccgtt/a /DNAH3/"dynein, axonemal, heavy chain 3"/ 1227/16/rs330149/20959502/[g/t]/gcctcccaaagtgttcagattaaggcgtgagctaccgcgcccagccag acagatcttgat[t/g]tgagttcttgttttgctaccgactagcatgggcaagttatacaacccttgtagatctcta/t/ DNAH3/"dynein, axonemal, heavy chain 3"/ 1228/22/rs756053/28416144/[g/a]/caatctgcatcttcaactgttcctcctcactgctacctgaggattttg ggtggcccatta[a/g]ggtacttctgagaaatggccccagggtctggagaaagcaagcctggaaggcacctgtgac/a/ 20 NF2/neurofibromin 2 (merlin)/ 1229/14/rs2747005/85145817/[g/a]/ccagagcatgagtgggcacctgcacgccttaaatggggcctgccctc tgcagtgagccat[a/g]agctgggggagcagccccgcacctctattctcaggtgagacagggtcacctctcgtgagt/a /FLRT2/fibronectin leucine rich transmembrane protein 2/ 1230/3/rs1995209/2407612/[g/t]/attgaatgtcttttaaatagtttgtactcaaaaatggcattttcttctt tcagaaaatat[g/t]ttgttcttcaagtatgtttttgaggttataaaataagagatgcaaagcagaattcataat/t/C NTN4/contactin 4/ 1231/3/rs7630653/29939556/[a/g]/tgaatcatgcccacagatgctattgcttcattatcccttaatctaggg attacctccatt[a/g]gctaactcgatgacatgtgagggtttcaaataagattgcctctcccttgtaacatacatc/g/ RBMS3/"RNA binding motif, single stranded interacting protein" 30 1232/10/rs4746675/68622064/[a/c]/ttataaaaatcttcttcttctgcaaaaaatcttctgcaaagcaaagc aaacaaccaaaaa[c/a]atgaaaaggcaacacacagaaagaatgggagaaaatatttgtagaccatgtattcaataa/c /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1233/21/rs1056892/36440576/[a/g]/aatgcgtgctgcccaggaccagtgaagacagacatggatgggaaaga cagcatcaggact[a/g]tggaggagggggctgagacccctgtctacttggccctcttgcctccagatgccactgagc/a /CBR3/carbonyl reductase 3 1234/10/rs1927457/30048669/[t/c]/gagatgaacagtagactggataggattaatagcaggtagacatttca gaagaaaagacta[t/c]tgaacttgaagacatagcaatagaaatatccaaaatgaaaaacagaaaagaaagtttaaa/c /SVIL/supervillin 1235/14/rs1956001/32480772/[c/t]/ggggcataaaacaactgtttggataagggaccaagtttgcggttgtt 40 gccttttgaaagg[c/t]ttagtttataactccttccttcctatcttccacagtgctcctgcccccaccccgctgtta/t /NPAS3/neuronal PAS domain protein 3 1236/16/rs4076548/48405440/[t/c]/aaaagaaaacaagcagctccttcctcaaggacgttagcaggatttgc cgaactcccactt[c/t]ttactcctggaaagcccagaggacgcaggaagtgacagttccagggaaggcgtgaggtcg/c /ZNF423/zinc finger protein 423 1237/1/rs267916/180786189/[t/c]/ccttggattggatcccttggaggtcaatcttggctaagactgaattta ttttctatggca[c/t]tttggatctggtggttttgcctgctgccctcctcccctctccttgagggacagtctgttc/c/ RGSL1/regulator of G-protein signaling like 1 1238/10/rs1051723/102887047/[t/c]/tctggggtccccagggctgtcatctgaatttgccctgggaaacccc ttctctgtgaccca[c/t]ttctcatcacacacatggaaacccataggcccacacacaggtggtgtcactgtccctcct/ 50 (116) JP 2010-88432 A 2010.4.22 t/TLX1/T-cell leukemia homeobox 1 1239/5/rs6896680/60027288/[c/t]/acatatcacacttcttgattgtttctatcccactgagcgactatctgt tcctgtgtaata[c/t]catacagttgtcattacagtcaattaataccaagtataaatccctggtaggacaaggccc/c/ DEPDC1B/DEP domain containing 1B 1240/1/rs1775654/39722667/[t/c]/tctaggggaaattagtaaaacaaaaggtatttgaagacattttgaaat ttttatttggaa[c/t]ataaaactttgattttgggaattatcaaaatatatgacctaggatactttaagagaaatc/c/ MACF1/microtubule-actin crosslinking factor 1 1241/5/rs6555837/168308872/[t/c]/cttcccttccagtaagtgtcactgagcatgggccacagagaatcctg cagtcatggggac[c/t]gttcagcgtctttgcagacagtccaggaggaatgagaccatgagaaattcaaagcaactg/t /SLIT3/slit homolog 3 (Drosophila) 10 1242/5/rs11134553/168305256/[c/a]/ggaaccctctccacatgctatacttttaatatgttctaggtctgct ttcagttattccaa[a/c]tatatcaacactgagagagagaaaacaatcccgactgctttagggctaaactcgggtgtt/ c/SLIT3/slit homolog 3 (Drosophila) 1243/20/rs6014052/52608246/[t/c]/aaagctcttgcttgaatgtgaaatgaataaagggaagttgaggacaa acttgctctattt[c/t]agacttctacctgctggctttggaatttaatatgtaaatctttggggaaattggtaagcc/c /DOK5/docking protein 5 1244/12/rs11065733/109778903/[a/g]/atgggcccctcagagaacattttcatcactgcagaacgtcctatt agaatgggatctaca[a/g]actacagccaaatctggctggctgctggttttttgtaattaaatctctattggcacacag /g/CCDC63/coiled-coil domain containing 63 1245/4/rs2710848/169777245/[c/t]/ctacagttatcagcccaacctgaatcacacaactctttccagaccag 20 gcacctgaagagc[t/c]tcctaactggctatccctacaacagcagtgacatcatcttcatgtgcaggttggattagc/t /PALLD/palladin 1246/4/rs2723688/169775791/[a/g]/tgcaaagaaatcatcagtaaagttctatatttttcttaggaaagaaa ataaagtaacacc[a/g]atgagaacagggaagtggaataagaggccactacgaagtgagaggtagcttccagtccta/g /PALLD/palladin 1247/1/rs9429940/205729535/[t/c]/ttggttataatgtgtttttaattatctaaagtatgaagcattttctg gggttatgatggc[c/t]ttacctttattaggaagtatggttttattttgatagtagcttcctcctctggtggtgtta/c /CR2/complement component (3d/Epstein Barr virus) receptor 2 1248/16/rs2075518/21125447/[g/a]/taccaataaaaccctattgccatgcatgatgtgccaagtaccatgta tataccctcagta[a/g]attcttagagccaccctgaggtaagcattattgtcccatcactttggacttggaaacaaa/a 30 /ZP2/zona pellucida glycoprotein 2 (sperm receptor)/ 1249/16/rs2242551/21124493/[g/a]/ggctggtgctcccttaaccaagtctctggtagtctaacaatttatca ggttaaaggtaat[a/g]tcacctttaacatagaattaaaggttattaaggtctgatttttaaaatttgcttcatacc/a /ZP2/zona pellucida glycoprotein 2 (sperm receptor)/ 1250/13/rs9526786/51107423/[g/a]/agctactgcacccccggcaggaagtcctaaaccttttaaatggcaag agttgagagagaa[a/g]ttatgacgtgatcatcatttttcatgccaggctgtgaagaacagcagctttgcgtaattg/a /WDFY2/WD repeat and FYVE domain containing 2/ 1251/13/rs4555048/51083856/[g/a]/cgactcaggactgaatcctgatgactccaagtctgttatggtaaatt cattccctttgcc[a/g]ggggtttggtttaggattaggcatgagacccagttctggccagtgataggagcagggaag/a /WDFY2/WD repeat and FYVE domain containing 2/ 40 1252/10/rs2366698/127965325/[c/t]/caggaattaaggcacggcagcattataatggggtgtccctggattg gggcctgtttgtta[c/t]tacataaataatgataatgtttattcttgagttactgacaatttttccgatggataatta/ t/ADAM12/ADAM metallopeptidase domain 12 (meltrin alpha)/ 1253/14/rs1255718/63078562/[c/t]/cttcactctaactctaacactacaacatttcagtaaatcctcttcct ccatcactctttt[c/t]gtctcttctttattccttatctctcatctctacagacgatatataggtagcttttaaaaa/t /PPP2R5E/"protein phosphatase 2, regulatory subunit B', epsilon isoform"/ 1254/7/rs2300012/107720923/[c/a]/ccacccaccagctgtatcctagctcataggcctgaccccaactgagg actacaacagtat[a/c]atgaaaactgtgcttctaattgtccagcgggcgatcacggcttggctaagaaaggctctt/c /NRCAM/neuronal cell adhesion molecule/ 1255/11/rs2041032/17499225/[t/c]/gcccatctcctgcatatcggagagccccagccagcctggggagaagc 50 (117) JP 2010-88432 A 2010.4.22 ctcatggttctag[c/t]catgatgaatcaagcaaagtccccgagcttgtattctaaattgagtgtgaaccccacctt/t /USH1C/"Usher syndrome 1C (autosomal recessive, severe)"/ 1256/1/rs7545070/238566113/[g/a]/cgaaactccatctcaaaaataaataaataaataagtaaaaataaaga aagaaaaagacaa[g/a]cagccagcgcctctgaatactatttccgcatctgcatttgccacctacaagtgctaggtg/a /FMN2/formin 2/ 1257/13/rs713280/29746943/[a/g]/agtgtgtcagatctctgcactctcatgttcatttcagcattactgtaa tagccaaatatg[g/a]aaacaaactaaacatacattgacagatgaatggataaagaaaatgtgtgcatatatgttg/g/ KATNAL1/katanin p60 subunit A-like 1/ 1258/18/rs7235554/54204684/[c/a]/cttctatacagatacatggaaaacacattttcttaagctgagttttt atttattttatac[c/a]cagccacctcatgacagcttttaccctgttacagagcaaagtgggcactgcccagatcga/a 10 /NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" / 1259/11/rs9326345/103424432/[a/g]/tagtgttgtgtctcctagttcacctcaaacattctgtatcttctta ttctctctccatgt[a/g]aatgaaaatgtcttaacagaaaccaacctaattgaaagattaccaaaaccctatggagag/ a/PDGFD/platelet derived growth factor D/ 1260/1/rs3753563/173189969/[a/g]/ctgtggggtgatactgagcatccacctgtgtgattggcacaatgtga aagaggggaaaag[g/a]gtggaggaggaagagacaggagagctgatatgaaactcttgttatttatgaggtaatcaa/a /RABGAP1L/RAB GTPase activating protein 1-like/ 1261/10/rs10822705/67512740/[a/g]/gcacactttttaagtattgtcatatatatattcatccatcagagtc tcatctcccaacac[a/g]gtgcagcatattttcctgaagaaaaagagtcccttccctaaaggaaagtctaaaactatt/ 20 g/CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1262/4/rs1355161/126487591/[g/a]/tttagacctttgtgaaagtgttaccctctcctttaaataagggctat actgtggtaagag[a/g]aatatttaagatataattcagtgactctaggaatgggagcatttacacttcttgaaagaa/g /FAT4/FAT tumor suppressor homolog 4 (Drosophila)/ 1263/17/rs4790823/1151041/[c/t]/gagtggactgctcacccccggattgtttggaacccccttgaccccagc agcacaaacaca[t/c]aggccagaggcgagcacgtacattcaggtttatttatttccatgctaagacacacagcgg/t/ TUSC5/tumor suppressor candidate 5/ 1264/15/rs4318151/48516566/[g/a]/gtgtattttttgttacttgcttgtttaacccataacttcctaacttt tacatctctctgg[g/a]tactctcttcatatttatgtatgttgcattgctttactcacgtttgcgttgttatgctca/a /USP8/ubiquitin specific peptidase 8/ 30 1265/3/rs9847121/54998861/[t/c]/agttgtgagctgcagccatgatttttgttgtcgatctttgttctgtct tgaatttgcttt[c/t]cacttagcaccaggtattgcttcatctacatttacacgtctccctacaggcttcctatga/c/ CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 1266/21/rs2838126/42092165/[a/g]/ttgtagcaattgctttaagacaacccattttgcctcagacagtgacc ctattaagaccac[a/g]tatgtttacagaaaacttgggagtttgatttttctttagagttctcacttataacaagaa/g /PRDM15/PR domain containing 15/ 1267/21/rs2236691/42093247/[c/t]/agacgtgacagcacgtgtccccgcacacgcagacctggctgttcacc gcacattcagttt[t/c]aggggcaattaatgcttctattagtgaactaacctctctgctttcattaccacctggcag/t /PRDM15/PR domain containing 15/ 1268/9/rs10761134/93686804/[c/t]/caaactcattactctcttggatttttggctggaactggagctaacac 40 atcctgcgggctg[c/t]catacacattcaagactcttcccatccacagaccataacatgtctccatttccagtttgg/t /ROR2/receptor tyrosine kinase-like orphan receptor 2/ 1269/9/rs7858642/129895939/[t/c]/gtgatcactggctgattggggctggcctcaccaaatcacaaaaagga cctccagaatgtt[c/t]tggaaacatttttgaaaagttcactttaggccaggcgcagtggctcatgcctgtaatccc/t /SLC25A25/"solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25"/ 1270/5/rs6594659/112402461/[c/a]/gaggggaaaggaagccctcttctggtggatgagtcaggggcatcctg tccctggacagaa[c/a]ggccactgtgatttgtcgattgccttaacgtggcattttacagaaccatctggcaaacac/c /MCC/mutated in colorectal cancers/ 1271/2/rs749264/241803980/[t/g]/gaggggtggacgcagtgagagccaacagctttgcagatcggactcagt 50 (118) JP 2010-88432 A 2010.4.22 gaaagcgtctgt[g/t]tctgttggtcagatgtgggagggcagtccacccgcccagccccccgcattgttccttaag/t/ TMEM16G/transmembrane protein 16G/ 1272/7/rs739557/116542098/[c/t]/cagacaaaggaacaataaacaaggcctttccatcaatcttgcagacct aaaagtagactc[c/t]ttgttcaagatgcctaggttcttcctatccaataagtcctcctcttcttttgaattgcat/c/ ST7OT2/ST7 overlapping transcript 2 (antisense non-coding RNA)/ 1273/5/rs891916/171145942/[a/c]/gctgaatgaacgaatgaactgataatactcctgaattggagcgctcct ggaggattcatt[a/c]tcagggctgaaattcaaaactcatgtgggatttcgtcaaaatggaaaacattaatgcttg/a/ LOC644994/hypothetical LOC644994/ 1274/8/rs450738/68719382/[c/t]/aatagaggcaaattccagactttttgcacaggcagagctcttacaagca tgttcttgctg[t/c]tagatatacattcagttctgtgcaccggaacttgaagagggattgcagactgtggggact/t/C 10 PA6/carboxypeptidase A6/ 1275/8/rs6472326/68711389/[c/t]/ttactccccaagtccctctcgctaaaacctccctttaattttgatggc agcttaaaaaac[c/t]gtgtgttttcagaaggaaagatttagggtactccataactaaggctcatctcatattctc/t/ CPA6/carboxypeptidase A6/ 1276/8/rs6998443/68704404/[c/t]/tttaagaaaaattaataaagacaagtaagattatgtactcaatttttg gtgaatctgtga[t/c]ggatagcggttgttgcagtggtgggttaaatcaaggaatagatgtttgcaaagctaaaat/t/ CPA6/carboxypeptidase A6/ 1277/6/rs7774274/74471331/[t/g]/aatattaaaagtgcagaaggctagaggagtttttattttttgtataaa aaatacaatgcg[g/t]tttgtaaatagtgcttcttgtatgtgagcctgtgcctggtactattatcttttacttcca/g/ CD109/CD109 molecule/ 20 1278/6/rs2744294/25404585/[g/a]/ctccttgtggagccctgtcctccttgctgaggccctcaagagtgcagc ctgcttttctgt[a/g]tcctttcaaagctaccattgtgtactatgttgcttgtggctgtcttttctttcaagcctg/a/ LRRC16/leucine rich repeat containing 16/ 1279/5/rs10514265/83679257/[c/a]/taaaatctaataggagtaattcttgcatttgatttcacatattatac aagtctatctttt[a/c]acaaccattatattcatcttctttcccaatattaagctgtattttccttgaaggtagaga/a /EDIL3/EGF-like repeats and discoidin I-like domains 3 1280/4/rs10857319/159949244/[c/t]/gtttccagaacttctttaggacttgggccaacttgagggtagaagt gaattattgacagg[c/t]gcttgcactgaaggacctggctccagagtgctcacagttatctgtttgtccaagtcatat/ t/KIAA1450/KIAA1450 protein 1281/1/rs3820071/15681354/[g/a]/ttcaaagccaggcctctggaggtgaccctctccctgggacccctttct 30 cccagctcctcc[a/g]ggatctaccgcgtgatgctgggccagcataacctctacgttgcagagtccggctcgctgg/g/ ELA2B/elastase 2B 1282/2/rs3770858/36550025/[a/g]/aacatgaccttcatccaggctcctcactgttagtgctgcattttaata ctgctgtgagaa[a/g]cagagtgctacagggacagtgctccaaaacagaagtatttcaaatggcacaaaacaggct/a/ CRIM1/cysteine rich transmembrane BMP regulator 1 (chordin-like) 1283/3/rs9844797/127703229/[a/g]/aagatgattcccaaaattattcggaaaaataggacaggaaaaatcaa agcatattttggg[a/g]aacagaagatttgaacaggccttgcaggtagtagagatatcaaaaagcagcaatgcacag/a /UROC1/urocanase domain containing 1 1284/6/rs2803108/162985009/[g/a]/tgggagaatttccgtctgtgcttggccccaaagctgctgtttagcaa gacatgaaacagt[g/a]tctaagaaagattaaatgtatgttttctatatatggttttacttaataatctgctgcaga/g 40 /PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 1285/17/rs3785928/45258145/[t/c]/actgcctttgtataaacaaaaggggaagaatgtgtatttgcatttac atgacacaggagt[c/t]ccctcttattcacagggaatgtgttccaaaactcccagtggaggcccaaaactgtgggta/t /MYST2/MYST histone acetyltransferase 2 1286/12/rs2066808/55024240/[c/t]/gctctttagccctccgccctactgccttcttagactagcttctgctt attctaccattcc[c/t]gatttcatttgaaccactgagccctgcccctttgtctgtctttgggtatccagacaggtg/c /STAT2/signal transducer and activator of transcription 2 1287/12/rs2306693/54966798/[c/t]/ccctcttttatattaacaagaaggaattacagtgactcaacctctct ctcttcatctcag[t/c]ctcttagggcagtttgacataagaaagctgtaaaagtccccaaacagtttggaaggagtt/c /CS/citrate synthase 50 (119) JP 2010-88432 A 2010.4.22 1288/12/rs744051/54953565/[g/a]/ttccctcttttccctctaatttgtaccaaaccctattgttatctgcca tgcacaaagtca[a/g]ttaactcctagtcagagcagggacttccctcacagagcattttgataaagttgactatga/g/ CS/citrate synthase 1289/3/rs11922733/184743453/[t/c]/gatggaaattcactaagtccactcagcactgtagttctgaaagttt aacattttgcattc[c/t]ttcccctccaggtatttgcacattaagagagataatactggctgggtgaggtggctcaag/ t/KLHL6/kelch-like 6 (Drosophila) 1290/18/rs4602126/42202580/[c/t]/agccagttggaccttctgaggcaattcaattctgttcttttcaggac agctctatggagt[t/c]gagtcttaatcagttgcacaaggcaccatgaagtgcttactgtgtacctaaacctggctg/t /RNF165/ring finger protein 165 1291/13/rs4772158/98372056/[t/c]/tggtgacattctgtgaggtaccaaagagcacttttcagttattacag 10 agaagaaagccta[c/t]gtcagtgtctgcaccttcacaccagcccagggatggtctccttatgctggtggtcagaag/c /DOCK9/dedicator of cytokinesis 9 1292/13/rs4444196/98369972/[g/a]/gagccttctgtgtgaggggaaccctgagaaaaatgcctgaatgatct tcattctgagatt[g/a]cttgggcagcttctgactaattggattgcctttatctcatgtgcactgtgaattgcgtga/a /DOCK9/dedicator of cytokinesis 9 1293/12/rs1882182/80247518/[a/g]/gtgagtcgcatctatggagtcatcctgagacagtggtctgaccctgt tttcaagagggtg[a/g]tctggcaattggatccctcgctcccactggcaagaatggtattgtatgagattgaatcag/a /PPFIA2/"protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), int eracting protein (liprin), alpha 2" 1294/12/rs11046274/22092183/[a/g]/gaaatgaactagagatcaaaatcatattcacagtaaatggagaaca 20 aaactgttaatacc[a/g]tttacaactcttaggttgtatatatcaggaaaccctgttcaaactggcataacaaaagag/ a/CMAS/cytidine monophosphate N-acetylneuraminic acid synthetase 1295/2/rs1921765/153846483/[g/a]/agatataaaattcttagttgaaatttttttttctttaaaaatgcgga aaatatgtcccca[a/g]tctttcctgacttgtaaggtttctgctgagagtctactgttagcctgatggagttccctt/g /LOC391453/hypothetical LOC391453/ 1296/15/rs2279357/72417676/[t/c]/accaccagctcctggtgtaaccctgcacagtgcctgataatgcaccc ttagtgctgcatt[c/t]ccttgatttaggcctagaccttaacttgtctacaaacctcagtcctatcccatcccatca/c /CYP11A1/"cytochrome P450, family 11, subfamily A, polypeptide 1"/ 1297/1/rs3924436/24781546/[a/g]/agttcatgactttgaggtggggagattatcctggattagctgagtggg cccaatgtcatc[g/a]taaggttctttataagggagaggcaggagggtcacagagagaggaagagatgtgatgatg/g/ 30 C1orf130/chromosome 1 open reading frame 130/ 1298/17/rs2672901/76411261/[a/g]/acgtacacacacttaaacatacacacacgtgcacaaatgtacacaca tgcacacatgcat[g/a]catacatgtgtgtgcacaggtgtgtacctatacagatacattacacatgggcacgcatac/g /KIAA1303/raptor/ 1299/20/rs1293381/51242306/[t/c]/ttgctctgtgccaggccctgtgttagaaagtgacaatgtaatacaca aaggaggttgtcc[c/t]tgtcctttggaagccttcttgtctgacatgcacaagcaaagttgtttttttgtttttttt/t /TSHZ2/teashirt zinc finger homeobox 2/ 1300/22/rs13433666/44280783/[t/c]/agatgaggcttgatgtgaggggagcgcgggaagagcgcaattctgc caataccccagaat[t/c]gttttccccaagatgcctctgcacattctactactactgaatttcccagccaggcgctga/ t/FBLN1/fibulin 1/ 40 1301/1/rs4339837/163790071/[c/t]/aacccacatgaagattttagaactgcacacagtacatgttcaattaa tgctagctgtcgt[t/c]gttgttacaaattctttgcctggcagtgattctgagtgtcacacgagatgcagaggacgg/t /LRRC52/leucine rich repeat containing 52/ 1302/7/rs2881991/48014249/[g/t]/cttgacattttctttttctctctactagtaattttcaaactgtaaaca tagaaaacccat[g/t]cttggccgggcgtggtggctcacgcctgtaatcccagcactttgggtggccgaggcgggt/g/ SUNC1/Sad1 and UNC84 domain containing 1/ 1303/7/rs1915960/48011003/[t/c]/tctgcagtttttggttcccctctaccaactgcctgctttgtttacttt ttagcccactca[c/t]gtagttgctttttgaattttgtccggattttttctcattgtaatcagttggaagagactt/t/ SUNC1/Sad1 and UNC84 domain containing 1/ 1304/5/rs10805894/75182012/[c/a]/atatttgcaaaaaaatcacaaaatacttatgtttttattaggatttt 50 (120) JP 2010-88432 A 2010.4.22 aagctttgaaact[c/a]tagcttcttatttttttctaatcaacaacatgaaattagatttgtgagtggactattgct/c /LOC644601/similar to bridging integrator 2/ 1305/5/rs293002/58070723/[g/a]/aaacagagttctgggctttaaaaaataacagttgcatttgtgacttact tgaaccttaca[a/g]ttattttcaggaccatcgtgaatacactgtccatcaagtctgcttcctaacctcagccaa/g/R AB3C/RAB3C/ 1306/1/rs2076075/185089907/[a/g]/ataaacagtatcatccaaacatgtttaccttttctctaagtgatgtg tgataacccattc[a/g]tatacacagggaactcaacctatctagtgtccttgggtagactttttcttcctaagacgc/a /PLA2G4A/"phospholipase A2, group IVA (cytosolic, calcium-dependent)"/ 1307/6/rs1590054/145051345/[t/g]/gccagaattatttttctggctccttctcattgcagaaaactatttat tctaattattttt[t/g]aatttattttttgttcgactatgtgttcttttaaatttctttttctctccttgaggatgt/g 10 /UTRN/utrophin/ 1308/10/rs7915771/126235031/[g/a]/gtcccttagtattatggttagatgctccatgtgtttccaattcttc attattgtaaaccc[a/g]actgcattgctcatccttgtagcatagctttgcacttattttggatttttgctttaagat/ g/LHPP/phospholysine phosphohistidine inorganic pyrophosphate phosphatase/ 1309/1/rs678849/29017775/[c/t]/cagggacaaaagcaggaaaggcgtcgtaagcaggtgtccttcttaccat agtgtcaaaag[c/t]acctgctaggtgctgagcttggctgggctcgggagccacccatgattcctgaggagatac/c/O PRD1/"opioid receptor, delta 1"/ 1310/4/rs1374621/5176625/[a/g]/aatttaccttacctctcttctcctctgctctaataaaacagaggtcaca ggtgtgttgtg[g/a]aaagtaaatgagatcacacatgagaaggctaacaggctttgatcagagccccacacatac/g/S TK32B/serine/threonine kinase 32B 20 1311/6/rs707816/13742961/[a/g]/atgtaaagtcataaaaccactacattttagcatatgtactttttttcct cccttacctcc[a/g]ggggtacaaatttgttaaaagtcagcgacatgtttggctttgaatacgttcaagatttaa/g/R ANBP9/RAN binding protein 9/ 1312/7/rs2715135/50717622/[g/t]/gctctgggatttaggtgggaaaagtcattaacgtgccctcaggcaggg tcagagccatga[g/t]atctgctatttggtgtttttgggtaagtgtgtgaaaaggattggtaaccgtatttgaaaa/t/ GRB10/growth factor receptor-bound protein 10/ 1313/11/rs216486/16777742/[a/g]/aaataaagcaaaaaaaaattactgctaaaaaaattcagatcactgaag tccaagaaaata[a/g]gtataacctgggcagttttataaactcataaccagaaataattgaaggactttgtcaaca/g/ PLEKHA7/"pleckstrin homology domain containing, family A member 7"/ 1314/2/rs7603997/24378462/[t/c]/tgtcagtaaggtgcattgcaagaataaactcttctgcttttagctgtc 30 catcaccatcaa[c/t]gtcagccagagtcctaaagaaaatgttaaaattcacaacttaataaagtctatttggagt/c/ ITSN2/intersectin 2/ 1315/2/rs1000507/200411130/[t/c]/tctgtacttctatcaagtttctatagacaatttctctgcaggatact gtggaccctgatg[c/t]ttcttgtatgtgttccacgtcttcctcactctgtgctttcacatgctagacccagtgtct/c /LOC348751/hypothetical protein LOC348751/ 1316/7/rs7793555/80384681/[a/g]/atcagttatctgccattttatccagatgaccaacaggcagttgttaaa tgatgcagttga[a/g]gtaaccatggactagtgccaaattcaaaccaatgacctagtggtgagcaatccagtgagc/g/ SEMA3C/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3C"/ 1317/12/rs1732771/112028211/[c/t]/ctccccctcctcccagcctccatgattgcatcccctattgagggag 40 tggtctgaagtcat[t/c]gcgctcatcctcctgcctctaggggagcagagaaccatgcccgtccactgaggtcctccc/ t/RASAL1/RAS protein activator like 1 (GAP1 like)/ 1318/15/rs4887423/84588810/[t/c]/tgtagggtcgcgggggaaggaggtttagctattttaaatgttagtaa acatgagagtttg[c/t]tggggattaacaggaaatcatgaataaaatcattgggatttgataagggatttttctccc/c /AGBL1/ATP/GTP binding protein-like 1 1319/21/rs2244084/40198919/[g/a]/gctagggcaatgaaaccctgagctgcctaaaggtcagaatccaccat agtgagagatagc[a/g]agtgctgctgtgaataccagaggcacatgggtggtggcgccttcaaggtaaaaactcaaa/a /PCP4/Purkinje cell protein 4/ 1320/5/rs28636/66184869/[t/c]/gtgataatttaatctacccggagtaagtgtaactggtctagtcataggtt taataggtcc[c/t]gtgtgtgtgtctgtgtgtaggtcactgaaaaatcatttccccatatctttgttttctatt/c/MA 50 (121) JP 2010-88432 A 2010.4.22 ST4/microtubule associated serine/threonine kinase family member 4 1321/7/rs11768678/97584323/[a/g]/gggtgtgtgcacacaacatcacacagcatgacttgtcacttgatcac ctggctgagtagt[g/a]tttgtcagctttcaccctgtaaagttactctgtcctcccctccccatggtgtacgagtgc/g /LMTK2/lemur tyrosine kinase 2/ 1322/22/rs5768794/45242042/[a/g]/ccaaaatatgcgcaaataaaatgaaagggacacgcacagtgtgatcc cattttgtgaggg[g/a]gctgctttacttatgcacgaacatgttatatatatatatatatagaaaactctggaagga/a /CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Droso phila)"/ 1323/10/rs2947063/32943723/[a/g]/ggggaaacagggtggaaccacccaccttctgccattagcacctgcac atgtcctttgggg[g/a]ccaaggagtttgatctatcccacccactgctgctttctatttttccactctgtgtgtcca/g 10 /C10orf68/chromosome 10 open reading frame 68/ 1324/1/rs4949800/77630271/[c/t]/ccttttaaaagatagaattaacagctgcattttcctcgttctacaaca aatggacaggta[c/t]gtagactccaacatactccttgaataaaaatgagaaattctagaatccttggatcatgca/c/ AK5/adenylate kinase 5/ 1325/2/rs1366678/144572970/[c/t]/ctgagtgctaagccaagcttagtgatggtgctacagctccgcactga tttccctttccag[c/t]gttttacacattgcttgctccctaataatatttactgaaaatcaagaaaggagtgatgtt/c /GTDC1/glycosyltransferase-like domain containing 1/ 1326/7/rs12154357/48245670/[g/t]/cagagctccatggaaattgtacatcatgtgtgtgagctttctattgc tgctgtagcaagt[t/g]acccccaacatagtgccttaaggcaactgacattttcttttatcatagtgttctggaggt/g /ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13"/ 20 1327/7/rs1405127/48256210/[c/a]/ctacttggttcagtagaggatgctgtaagtattctaccatcttagctc ttctaagggcac[a/c]aatttaagattaaattcaccaaagatgctaatatttaacctggagtttcgatgaggaaag/c/ ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13"/ 1328/7/rs2049513/48263650/[a/g]/ttgcagtgaggtgagattgcaccattgcactagaaatcagttaagaag atgcaacaacca[a/g]gtaaatccctaataatgcaagaaaatgtcacactcattgtgaaattttgtgacatttttc/a/ ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13"/ 1329/7/rs10499674/48273843/[c/t]/ctcaccgaaatgagtgtcaaaattttaaggcattacaactaatggcc agggaatttgata[t/c]ggaagattttatttacctattttgtttaaaaaattatttgatactgttgagctttttaaa/c /ABCA13/"ATP-binding cassette, sub-family A (ABC1), member 13"/ 1330/13/rs17077384/31757048/[c/t]/actgactggttatgtcataagcatagaatccacctgagaacagaag 30 aaagaacccagata[t/c]ggctatgctactgtcgatcagcaggagttcaattattctgggcttttaaaagctatgcat/ c/FRY/furry homolog (Drosophila)/ 1331/22/rs2239844/44305776/[g/a]/ctgatagtgacaagaagagagaatgttgggagtttcttttaagataa gatgggtgtttgg[a/g]taaatgtctgacttggtctttttcccccttagataagatcattgaggttgaggaggaaca/g /FBLN1/fibulin 1/ 1332/22/rs138312/39532082/[t/c]/gaacaggaaattctgtgcccagaaagctaaccattatcatattttgcc agaaacccattc[c/t]acttttttgctacaatccctggaggctggaagcagtaaacagataggcagaggcaggggg/t/ SLC25A17/"solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17"/ 1333/14/rs242405/55709472/[c/t]/aagaaagggctgtttccttaaatagttgaatttcccaggctctgtccc 40 agctttccttgc[t/c]tccttattctgcacctttttcttgagtagcctatattattctcatgactttaactgcccc/c/ PELI2/pellino homolog 2 (Drosophila)/ 1334/11/rs10791263/132314718/[t/c]/ttacaaccaccaccttgcctccatctcaccgcagcccctcaaaat gttcatgtacacaga[t/c]gatgtggacccacagaagaactcaagcaaactttgaggagattgaggcctgtgaagaaag /t/OPCML/opioid binding protein/cell adhesion molecule-like 1335/1/rs1737352/14993113/[c/t]/caggagaggagagctgaggctcaaggtgagattttagcaaacgctgct tatgtaactgct[c/t]gtgaacaaaaggtcaggacctgtggtgttacttttgattaccctgaaataaccaatctgg/t/ RP1-21O18.1/kazrin/ 1336/1/rs10158131/167583234/[a/g]/actacacttgatctgagatgtcaaaacgggatgaggaaaagccagt catgcagaaacctg[g/a]ggtaaaaatacattccaggtagacaaaaagtataaagctttgggaggaagatggacgttg/ 50 (122) JP 2010-88432 A 2010.4.22 g/NME7/non-metastatic cells 7/ 1337/13/rs2497606/24477336/[c/t]/gcttgtgaaggcagcgcacacttgcttccaatgcgatccttgcagct tttccacccatga[c/t]atctgtatttgttttttcaaattttatgtatttttctatcacgaactttgattttttccc/t /LOC390387/similar to Striatin/ 1338/4/rs5343/148684442/[t/c]/atcatgtcagtgaaaaataattacccacaaatgccaccagaacttaacga ttcttcactt[c/t]ttggggttttcagtatgaacctaactccccaccccaacatctccctcccacattgtcacc/c/ED NRA/endothelin receptor type A/ 1339/7/rs2299297/104532531/[c/t]/catcttatacctataatagaagcggtagtaaacctaaatttagtgtg tttaataaaatgg[t/c]actgacgtgtctctagttgtaactatattaaaaagcttggctgggcacggtggctcacac/t /MLL5/myeloid/"lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophi 10 la)" 1340/9/rs4877894/86780202/[a/g]/agaagttctgattcatagagtattggaagaaaaatgtaatattaatag gttttgctctag[g/a]cagactaaagggggtctcacttttgccatcacattggcgttatttgtcatcacaagtcaa/g/ NTRK2/"neurotrophic tyrosine kinase, receptor, type 2"/ 1341/2/rs998429/115364053/[c/a]/gaaaggagacatgacttattcatctgcatatccatacctaaaatcaga gcaactgctaca[a/c]atttcgacacagtagtaagcatttgtggaattgtatctagtcttctccagtgggctgtgg/a/ DPP10/dipeptidyl-peptidase 10/ 1342/13/rs3949948/106716741/[g/a]/tttattctacaaaaggatataaggttgttcatcacaggttgagtgc tctgtgtacacccc[a/g]cctggaaaatagatggctacctgtactgttgacaaggtttcacaccgtcacgcaaacatt/ a/LOC728215/similar to transmembrane protein 28/ 20 1343/12/rs11178843/39550646/[t/c]/gacagataatagattttcatttccaaacctaacatttctggcagtc ctgggcagcacttt[c/t]tggagggaaatcaataaatcaaattttaatcagtatttattgagcacctgctaacataga/ c/CNTN1/contactin 1/ 1344/11/rs3737454/76545926/[a/c]/ctccacaagccatttgttaaaatagtaaaccatcatcccaggctagt tcctgatggcctc[c/a]tctggccctcctcccctggcccccagcactgtgcccacattttcaggccctggatgaaag/c /MYO7A/myosin VIIA/ 1345/10/rs1327002/14188487/[a/g]/gaaatggaaataccagcataaatgtatgacttaatttatacttaaaa gaaaatactttaa[g/a]tgtcccaattttgtatcctgcaaagtcctagaaacaaccaatccagtagtaattagtatt/g /FRMD4A/FERM domain containing 4A/ 1346/7/rs2527879/30623992/[t/c]/gcccctgtgccctgtcacccctccagcctccaccaccaaacatgaaca 30 tcagtattgaag[c/t]ggagggacgaaaggcatttgcatataggagatgctgtctatattggtggcaggaggaaat/c/ GARS/glycyl-tRNA synthetase/ 1347/2/rs2302561/71075330/[g/a]/aacgagcaccgatgccggggcgggagcccgcgcgggccggggtcgtgc agtctcaccgac[a/g]gccagcgtgatgaaggccacctggatgaagagcgacagccagctcagcaggtacatgaac/a/ TEX261/testis expressed 261/ 1348/1/rs551207/5930033/[c/t]/cctgggggacacaggggtgctgctgcaacagcaagtccaccatgtaacac tgcacgctct[c/t]ccaaatgattcagaaattccccaaaacgctgctttttaagagatgggggtctcactaggc/t/NP HP4/nephronophthisis 4/ 1349/6/rs2608897/131935156/[a/g]/tttagtctctgccattctgaatccacttaaccgtcgagcttatagtc taaatgctgggaa[a/g]gtgtcaacctctatgcccctgagctaccatttgtcaccatacaaaagtatgaatttaaaa/g 40 /ARG1/"arginase, liver"/ 1350/20/rs6089291/59901255/[c/t]/tccacaaattggcaatttgggctaggctcagctggaaaacccttcca tccttggctgggc[t/c]cattcatccatctctcatcagctgccagtttggcttggggctggctggtcttagagggaa/t /CDH4/"cadherin 4, type 1, R-cadherin (retinal)"/ 1351/3/rs8177213/134954917/[c/a]/cgtaggatttttggccaggagctgggcacctcaccggggaaaagaga aacacaatccatc[a/c]ctccctctatgcagaaggaataggaatgtggtggctaagtgcccttgcgagggagacaga/a /TF/transferrin/ 1352/10/rs2399864/12783648/[g/a]/ctgcctgaatttatggcagtctcctaaaaagaatactgggaaatgac atgaaggtcactg[a/g]aagatagatacttaaacattttgatgtagaaagcctggggtgatcatcacagacatgtca/a /CAMK1D/calcium/calmodulin-dependent protein kinase ID 50 (123) JP 2010-88432 A 2010.4.22 1353/15/rs12905452/87172427/[a/c]/aggtttccaggcggtggcatttgcatggggcctcaaggaaggtggg aataggtcagacat[a/c]gagctaaagagagggtgttttttgaaggaatggaactgtgtgagcaaaagaagggagtga/ c/ACAN/aggrecan/ 1354/17/rs2240570/12823514/[t/c]/ctcatcctcaaactcaatacccattccagcagaggctagggtggaca gaaatccaggcca[c/t]gcccttaaatgtgggccagtttgagtcccagtcccaggcttcaagagaggtgaaggtcga/c /RICH2/Rho-type GTPase-activating protein RICH2/ 1355/7/rs10954367/131529802/[t/c]/attcattattatctactcagttgtcaactagactggagggcatgtt ctagccaaaaccct[t/c]agggaatagggctggcagagtccagagaggcaaagccacttacccaagggctgcagcaag/ c/PLXNA4/plexin A4/ 1356/9/rs10817974/118815427/[c/a]/ttccatgtgtctcatgtttttctagtttttctttggacccttgttt 10 tattttttggcttt[a/c]aattaaaagtgtcctccccactttactgactgttctgagttcctctctacactcatatag/ a/ASTN2/astrotactin 2/ 1357/7/rs3779258/123169745/[a/g]/attaaaaaaatcggtttttagtttcagtggtagacttaatagttata gtgaattgacttg[a/g]ttactttagagactgattcaagattgaggttactgtggggattcatttgtgtgattaaaa/a /WASL/Wiskott-Aldrich syndrome-like/ 1358/3/rs1545596/158601220/[g/a]/tatgtttgaagctaaaattagatagacttccataagctttaagattc tgtaattatttgg[a/g]gtcagtgcaacaaaaaaaatgctggaaaataaactcttagcacaaatggagggggatttg/g /VEPH1/ventricular zone expressed PH domain homolog 1 (zebrafish)/ 1359/1/rs10495466/238575190/[a/g]/cactgatagccacataaacagtgatttgcagcagtgcctgacaaca tgttaaatatgaga[g/a]tgtaaatgtcaataacttttcaaatcatgctgagaatttcatcttggtcagtatgtctgg/ 20 a/FMN2/formin 2/ 1360/1/rs2480786/10490245/[g/a]/tctccccgccagcaagagacagaacaacaagcggctgctgccccctag aagctaccaggg[a/g]catagcaccttgctatatagacatcacatgaaaagatcctattatctcctctccatccca/g/ PEX14/peroxisomal biogenesis factor 14/ 1361/4/rs2279027/37580151/[a/g]/gggaatgcacaggcagggagcccaccagctgcaggccaaaatccaccg agacctcgttag[a/g]aagcagatgtttccttgctgtgaatgttattggttccatcttgggaagggtctgggaact/g/ TBC1D1/TBC1 (tre-2/"USP6, BUB2, cdc16) domain family, member 1" 1362/13/rs2520696/31671559/[a/g]/tggcagctattaggaagactgaagtgagccttatagttcagtgaaaa agcagatcatcaa[g/a]cagtacagacaggtggtgtaatcacatttatgtttaaaaccctgtgcattgaaggagtat/g /FRY/furry homolog (Drosophila)/ 30 1363/17/rs2949942/62929282/[a/g]/acaatacaatacaatacaatgcaatgcaatgcaataatcttacttca cacaaacttcctc[g/a]agtacccaaaactagaccaattctccctgtcagatcctctcaataatatcttgtacttcc/g /PITPNC1/"phosphatidylinositol transfer protein, cytoplasmic 1"/ 1364/19/rs198972/56071705/[t/c]/ccttctgaagcatcaaagccttagaccagatgaagactccagccatga cctcatgctgct[c/t]cgcctgtcagagcctgccaagatcacagatgttgtgaaggtcctgggcctgcccacccag/c/ KLK2/kallikrein-related peptidase 2/ 1365/11/rs1894177/117483474/[c/t]/gctatacaataaagaaccgacccttggcatcccaggactcaaccct cagtgcattgctga[c/t]gtaacttgctttcttgggtggggaatccaaatccagaacccagagccctggagaaatgtt/ c/TMPRSS4/"transmembrane protease, serine 4"/ 1366/12/rs7138776/2943410/[a/g]/tgacccaaacttcatgggaacaatagacttcagaggagtcaccagggg 40 caggaaatggga[a/g]ctgtgcagagccaggggtgaccctcctgggggatgggattgcatatccggtagagggttg/a/ TEAD4/TEA domain family member 4/ 1367/15/rs2955965/99727305/[g/a]/gggccagggtattctggtaccttctgtctctttctagctaagaggta gagagagtaaaga[a/g]atttcatggacaaatcagcatttccagcttctctcaaaaaccaggactggcactgtgccc/g /PCSK6/proprotein convertase subtilisin/kexin type 6 1368/3/rs9809320/24364623/[c/t]/tttggaagaaaaagtaaacaaagtgttagcagaccgaatcctgagata attttaaaagga[t/c]aacacgttaacgcaagagggttttcttttaaaaatataaggttggtttaatattagctat/c/ THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on cogene homolog 2, avian)"/ 1369/20/rs2426198/48854931/[a/g]/cacctcatttgctccctggcttccgggatctttcaaccttcatttca 50 (124) JP 2010-88432 A 2010.4.22 tcgctttcatctt[g/a]tgcatagagatgaggatgattttctgcctgggctgaatggaccttgctatgctaagattc/g /BCAS4/breast carcinoma amplified sequence 4/ 1370/10/rs11191161/103716518/[c/t]/ctgctttgaattcaggaggagggaaaaaaggtagcagcaaattgt gttgccatgtagcag[t/c]agaatgaataatggatatgagaacttctccaggactaaaacctgtcccccacattaaggt /t/C10orf76/chromosome 10 open reading frame 76/ 1371/3/rs6804657/31925469/[c/a]/aattggaaaccttgaaatcatttctacaggaagcagagccaggtcaag ggccttctgaaa[a/c]cattaactttaggtcactggagagaagtatcatttagctaagaagtgtcttagaataaaa/a/ OSBPL10/oxysterol binding protein-like 10/ 1372/2/rs1465821/85854766/[c/t]/ccttcctcgggtcctccttgcctttggccccacgaagaccaacttctt gggcaggagaca[c/t]gggagggagagcagattttgcaaaacaatattacgtcctttatgccactaatccatgaac/c/ 10 ATOH8/atonal homolog 8 (Drosophila)/ 1373/5/rs882015/168418871/[t/g]/agattctatggaagacaccaagtgaaaaaaggcactgtcccccctcta ggagcaaagtgg[g/t]gcagagacagggagctcaccgttcacacatactccagaatgaggataacaacaaaagccg/t/ SLIT3/slit homolog 3 (Drosophila)/ 1374/13/rs9568516/50580804/[g/t]/gctggagtaagtacctggtatgtgctaggaacaattacgtgcaggag cctactcctcaca[t/g]tatcatttccattactacctgacagaaaaacagacccagagaggtgaacttcccttaaca/g /LOC647166/hypothetical LOC647166/ 1375/7/rs10233673/111734241/[c/t]/aggcctgtccttacatccagctcttacaccccagaacactaataca cactcagataccgt[t/c]gagaagaaaaactcaggaataattatattatttctcaacattttttactccatccccagc/ t/ZNF277/zinc finger protein 277/ 20 1376/3/rs11710809/26689442/[c/a]/ttaacattccaccagatcagctgtacagaatgactttgagagaacag cacttctccttca[a/c]aatgtgaaatgagggttctggttggcgaagtaggtttatttattgtccaaaaattttact/c /LRRC3B/leucine rich repeat containing 3B/ 1377/5/rs3087980/56577563/[a/g]/tggggaagggaaaatagaaatgtattttatattctaaatcttaagagt cattaggttgat[g/a]tttgcaattttttatagttaatgcaaggcatgttaaaatataatttgtcttggttttaac/a/ GPBP1/GC-rich promoter binding protein 1/ 1378/14/rs10145691/46683431/[t/g]/attgaattcatttacaaagacgtttccaatgataagaagtatatta gtatctctatttgt[g/t]gatatagtaaaattaatcttgtatatttctaactctttgtcaatagccacataaaacaga/ g/MDGA2/MAM domain containing glycosylphosphatidylinositol anchor 2/ 1379/2/rs9677476/231834534/[g/a]/agtgctctacagtcagccctgggcccctcccactgagcccactccac 30 tgtgccctgtatt[a/g]tactttcctgagctagacctcacttccctatcccccactgtgctcatgctcccctgtgct/a /ARMC9/armadillo repeat containing 9/ 1380/18/rs8089066/4431785/[t/c]/gctgtgaagtgaaataaaaccagaggagggtatatcttgcatgctact agagatacattt[c/t]tgacagttatcaattcggcaatacaacaatttatttgatttccatttcactctacgattc/c/ LOC388458/hypothetical gene supported by BC040718/ 1381/17/rs401643/3386204/[t/c]/ctctaacctgggacctcagaagtttagcgaggcggtgtggggccagctc atcagccaggg[c/t]aagagggcagagcttgtgctaagggccagagtcacagacggccttgaattaggaaactgg/c/T RPV3/"transient receptor potential cation channel, subfamily V, member 3"/ 1382/3/rs300978/87406024/[t/g]/agctggtcaaaaaatgagttcattcattgagtgacttaatatccataaa gccataaagcc[g/t]tacataaacataaccgttcataaatggttatatgcttcaggaaatcaatgtgtattttgg/g/P 40 OU1F1/POU class 1 homeobox 1/ 1383/1/rs960227/244624189/[t/c]/acagctatgtagtatgtataactgacaaaacccaagatctctaacaca ttggaatgtaag[c/t]attcatttcctttaagaatagaatccaaacagctgtttctcaccaatatacactgtgaga/c/ SMYD3/SET and MYND domain containing 3/ 1384/7/rs193579/116627186/[c/t]/agatagcccaggtgctctgttaactcctggaagccagatcccgtgctt tgctgttacaaa[c/t]attctccaagtgtgcagtggtaggggagtggcctggctgtatacagaatgcccaaacctt/c/ ST7/suppression of tumorigenicity 7/ 1385/5/rs916981/136488800/[g/a]/agcttggccctgtacccccagctcctttcttgatttaactgattcatt catccattaaac[g/a]tgccatgaacacctgcagtgtgccaaggcctgagctaggcacaagggatacaagagtgaa/g/ SPOCK1/sparc/"osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 50 (125) JP 2010-88432 A 2010.4.22 " 1386/13/rs383353/112527549/[a/g]/tgtgagcagccctctctctcctgcttgtggcactttaccccgtcttg gttcttacctttg[a/g]cctctagaagtacgtgccagggaccatggcatggacgcaagtgcagaggacccaccgtgg/a /ATP11A/"ATPase, class VI, type 11A"/ 1387/20/rs10485815/51096895/[t/c]/aatgcatgttatgaacagggtaacttcactgtggctttcttattaa ccatccctgtgtat[c/t]gctctaaggagagggcagagtctcaaggctattcatgtttgaatgaaggtgctggaaaga/ t/TSHZ2/teashirt zinc finger homeobox 2/ 1388/17/rs8072896/52437831/[g/t]/aagtcgtccccaaaccacttcccctttcattgattaaatgacatttt aggataacccacc[t/g]tgcctgtgcctcctggggactcttggcagaagagtcaaggatgggtgtgccatagagaat/g /SCPEP1/serine carboxypeptidase 1/ 10 1389/6/rs240768/101064065/[c/t]/agggaatcagagaccttggtgttgacctgtgcagaaagactcgcttgt gtaacgttgaga[c/t]agatgtcatactgctggtccaggccaaggtagcagtcactcatgaaatataatgtgtaga/c/ ASCC3/activating signal cointegrator 1 complex subunit 3/ 1390/2/rs2067934/30842676/[t/g]/tctagccgtgagtggcagggagtgcctttggttgtcttgggtgactcc gaggtgactgcc[g/t]gatgctgtgggtgcaggacgtcaggtggggcccacaggcagtgagacagtgaagtgacag/t/ CAPN13/calpain 13/ 1391/8/rs1434933/69718665/[a/g]/cataaaaaaaaatcaggatatctatcttctcttaaaaatcagtgcagc tgataacactgg[g/a]tctatattctggaaatacttcacagtagtagcttcctcctgctctagactctgaggccag/g/ C8orf34/chromosome 8 open reading frame 34 1392/6/rs12663896/155598360/[a/g]/ataaagtgctgatcaggttcacccagaatgtccctctaatgtttgt 20 aaacatcacgaaca[a/g]tgggtgaactgaaatgtaatcacccaagtgactccttcagctacaatctgaaaagacaca/ g/TIAM2/T-cell lymphoma invasion and metastasis 2 1393/5/rs1901515/101739148/[g/a]/cacctgttgattccaactgctagaaactctctgagtttttattgact gctttcactttta[g/a]tgggaaatagtatttcctggctttttcatatgtcttgcaacatatgattgcattccagac/a /SLCO6A1/"solute carrier organic anion transporter family, member 6A1" 1394/18/rs518978/10475250/[a/g]/catgtggtctgaaaacttaataggattctaaagtgtccacatcacacc tgaaatgtttgc[a/g]taggtctgtactgtcaggcaaacgtgtgcactcacacatcactctcacctctgtctgtgc/a/ APCDD1/adenomatosis polyposis coli down-regulated 1 1395/5/rs6580126/154375351/[t/g]/acataaaaaatctagaattagaagtcatcaatctgcaaaaggaaaag gaagaattggttc[g/t]tgaacttcagacagcaaagaagaatgtcaaccaagccaagctgagtgagcaccgccacaa/t 30 /KIF4B/kinesin family member 4B 1396/5/rs481221/172278141/[a/g]/gtaacaaaaggtgcaagaaggggcagtcgaacaggaaggaggaagcaa aggctgggcgga[a/g]cctgcagcctggaaaagaacatatgtatagatatcaaagagcagggctggcgctaccagg/a/ ERGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 1397/10/rs3818673/24823390/[g/a]/ggcttgcatcctctctctgtaaaacaagagaattgtttgttaaagct ttattgactttca[a/g]accagtttgtccgggtgaatgcaccacctgagggttataaaaggtaccacctagaaggcc/g /KIAA1217/KIAA1217 1398/12/rs2271084/51061698/[a/g]/ccacagggggcccaggaagtggtgccaggggcagagagcatcactca ttggttcataaaa[a/g]agcaagaccatctaaattgatgataaagaaaaagacatgtctgagaaccatctcaggctg/a /KRT84/keratin 84 40 1399/12/rs2271085/51062410/[c/t]/atatagcatacagatttgagtgagaggaaagatatatgatagcaaat gtttgaaaatatg[c/t]tagcccaggctaagcattcagggagtccaggccaagcattgatctccttgggtgccctag/c /KRT84/keratin 84 1400/19/rs17160491/8418940/[g/t]/agcctgggcgacagagcgatactccttcttcaaacaaacaaacaaac aagaacactgaag[t/g]tgctatagagttttaaggttggagcactggcagccagctgatgggcagtgaatttggatt/g /HNRPM/heterogeneous nuclear ribonucleoprotein M 1401/9/rs10491897/28329748/[a/g]/ctgtaggaatgaagttctaataacagatcttcacattgtttctacca ttgcctggaaaca[a/g]taaataatattcactactggttttcaagtatatgcagatttcattatgataattaaagta/g /LINGO2/leucine rich repeat and Ig domain containing 2 1402/19/rs11881082/43721041/[a/g]/tttggccaaaaatcaatttgcccaaatggacaatttgtcacatgct 50 (126) JP 2010-88432 A 2010.4.22 attttcccacaggc[g/a]ctctgcagtggctgccaaagttctatacacgtggtggatttctgtactttaggtccagaa/ g/RYR1/ryanodine receptor 1 (skeletal) 1403/1/rs2147333/17519113/[g/a]/attttagccaagtaagattcatattttggacttctgatcttgcaaact ggtaagtaataa[a/g]tttgtgctgtttgaagtcactaagtttgtagtgatttgttacagcagcaatgtgttatat/a/ PADI4/"peptidyl arginine deiminase, type IV" 1404/1/rs469846/91302177/[t/c]/agcaaattctaaggagcccatttcaagcctctgcttgtgtcttatctaa aaaactccctt[c/t]gcaaaggcaaatcacatgattaaggccaatgtcaaggggaggagtaggagtgcactgcaa/c/L OC647597/similar to Histone-lysine N-methyltransferase 1405/4/rs12643937/10187078/[t/c]/taaaaagagaaagggagttgctcaatagatttcatatctgcatccca ggagagttatggt[c/t]gtgttgcatggatgtgtggagggtcatccatcacccacagacaccagacagctccagaga/c 10 /MIST/mast cell immunoreceptor signal transducer 1406/5/rs10514231/81343168/[c/t]/ctccttagctaagcacgcaaaactcttgcttaaaaaagattattctt ttgagcctggctt[c/t]gttctctcaacgttacatttgtgcatagcttaattgctgatgattggtcagaggttatgc/t /ATG10/ATG10 autophagy related 10 homolog (S. cerevisiae) 1407/13/rs11842667/100704146/[t/c]/tgtaaataaagttttattggaaaacaaccattctgagacacactc acttttgtacaattt[c/t]agagttgagtagttgagacagagagagggtggtctacaaaaggcaaaatgtttactatct /t/NALCN/sodium leak channel/ 1408/13/rs8000776/73372852/[c/t]/tagtaaaaaaattgtttctccaacaccacaattgaaattgcattctt gaaagaaagtgaa[t/c]tcattctgctgccaaaattagtcaaatgtctacatgtttttcctttaacaataacactgt/c /KLF12/Kruppel-like factor 12/ 20 1409/8/rs11993947/125040636/[g/t]/caataaattagtgaatgagtgctgtagaagaagctttagctgactg cctttctacctcga[t/g]gtctcaccctacagaatgtacagaatgaacgcccctagagggaggcatatgtgatttgct/ g/FER1L6/fer-1-like 6 (C. elegans)/ 1410/3/rs10935153/136235615/[c/a]/tcagaatttcatttctctgcttctcttttttttttaaactctgaga aggaaagaaaaaca[a/c]ggttagcaactgtatcctgtatttcttcaggaaagaaatgagccacttcaaagctgagct/ c/EPHB1/EPH receptor B1/ 1411/18/rs637001/41820643/[g/a]/agacataaagtaccctgttctttaactatatataacttaggacctaca aatctacaaata[a/g]atgctagtctttacaatcagtcatcatttcttcttcatttcataagcctccctctttctc/g/ PSTPIP2/proline-serine-threonine phosphatase interacting protein 2/ 1412/4/rs1503293/167230135/[t/c]/tcagaatcttctgcatcctacgcaatgtgtgtactccactgggttac 30 agagattaacaag[c/t]gacacattccttcagttatcacctgctttgcatgttgtgcttcaggataaatagactcta/c /TLL1/tolloid-like 1/ 1413/8/rs10098719/17699686/[c/t]/cacttcctttagtgaggactttcagggtatattcaagctttcacaac acagagaaagaac[c/t]caactttgagatatcaggaagacgtgttcccccgcccccccaaataaatactttgctgag/t /MTUS1/mitochondrial tumor suppressor 1/ 1414/18/rs9807754/57677603/[a/g]/cgcaaattcaaacttgacgtgcttcagaaacgtcgcatcagtttcac acactgttcccag[g/a]gctcccaacacatgcgtcagagacataattgcaaggctaagggttccggagagtcaggga/g /RNF152/ring finger protein 152/ 1415/17/rs12165053/12745526/[c/a]/ttgtatgaataaaggactcatgggtggggccatggtagaagtgaga ggccagttacacag[a/c]gatgggaacaatttcagtgagatgcaacgaggacctgaagatggagaaaaatcggcgtcc/ 40 a/RICH2/Rho-type GTPase-activating protein RICH2/ 1416/17/rs6502692/2966475/[c/t]/ttacctgtaggtgttaaggtgcattatattcttcttaaggataataga gtcacagaatga[t/c]gaagaagaaccaaaccatgatctcagagttcctgctcctgggccttccatccaacctgag/t/ OR1E3P/"olfactory receptor, family 1, subfamily E, member 3 (gene"/pseudogene) 1417/17/rs4300683/2942322/[a/g]/aggtataccatacaaagtgtcccatagaagagggagactgcacccaaa tgggaggcacag[a/g]tggagaaggctttgtatttcttagagactgagggtattctgaggatggctctgataatca/g/ OR1D2/"olfactory receptor, family 1, subfamily D, member 2"/ 1418/16/rs12449216/6493773/[a/g]/gcattttctgatgtctactggaccaaatcaagacacacagccaatcc cagagtgagtgat[g/a]tctcgcgatggaggaagcttcacactcacctggaaaaggtatatgcaaatggggatggga/g /A2BP1/ataxin 2-binding protein 1/ 50 (127) JP 2010-88432 A 2010.4.22 1419/15/rs2934442/55550085/[c/t]/tctgcaagtcactcctggtgttttacctgagctgcctagagtcactt gctgtgggttagg[c/t]tgtagaagacaaagatatgctggtttatctttagatatgcggattcatttgccatcaaat/t /CGNL1/cingulin-like 1/ 1420/12/rs7315980/51735588/[a/g]/ccggacccctatgccctgtcccctttccaccctgcccatctctctct gttggtggccccc[g/a]gccccagttgcacccctgcattctccccaggttcaagacttcggctggcctgagctgcat/g /TENC1/tensin like C1 domain containing phosphatase (tensin 2)/ 1421/6/rs1982756/41313748/[a/c]/caactaacatctagtgagactgggattcaccactcagaatgggggtcc accatgagcaac[a/c]gatttgaggtaccagtgcatagcagctgaatgccagccctgtaaaagaccaccataaaga/c/ TREML4/triggering receptor expressed on myeloid cells-like 4/ 1422/6/rs374336/40631948/[t/c]/ggtctgggagagctgggaggagccatggaaatcagaggccctcccacag 10 cccctcctaca[c/t]cttggcccagactgggtagccagctttcctgtctagcagcagggacccagccccgactga/c/L RFN2/leucine rich repeat and fibronectin type III domain containing 2/ 1423/5/rs750728/80565512/[a/g]/aggatggtggggaggggagacggttacttgtctcattatcaatgtgtta gtattagtgac[a/g]gcaaaactgaatctctagcaatactatttgcccgtttaaactgggcctggctattgggct/g/C KMT2/"creatine kinase, mitochondrial 2 (sarcomeric)"/ 1424/2/rs6755935/99762971/[c/t]/gcatctgaaggactactgaagtgtctaatgagcatgtgttcataatcc ttttctatgggt[t/c]gttctgatcactgtaggaggagcaggacttatctcccatctccaaacactctcccttgac/t/ AFF3/AF4/"FMR2 family, member 3" 1425/2/rs1821421/133681364/[a/g]/atagattaaaggggaaaacaaatctcaatacacatatatcggggaaa ccagcccccaaaa[a/g]agccctgtaggtcctttctattttccctaagtgtcagttggtctgagaaataaagagaaa/g 20 /NAP5/Nck-associated protein 5/ 1426/18/rs1539864/17695732/[t/c]/gtctattaccccaatgtgtctttaacagataaaatttaatttaactt ggtattaaggata[c/t]actaatctcaaagtaaacacaggctgcacagatgtgtctacttttggaaataagagttat/t /MIB1/mindbomb homolog 1 (Drosophila)/ 1427/4/rs4692137/26614333/[g/a]/ctcctgttcagttacttaagatagaatataggcatttaggcattgcac ggagtcctttgg[a/g]gaaggtgaggtgctggcagaatttaattatagacagatgcattagtttcctgttcctgct/a/ STIM2/stromal interaction molecule 2/ 1428/15/rs12899040/49466762/[t/c]/ggtggggacgttcatcaacaaatacttattcagcagatgtcgagtg ctattggggaacta[c/t]aaaagacacaggcactgttctggaactttccatctttggtggagaggccaacatccacag/ c/GLDN/gliomedin/ 30 1429/20/rs6141035/9720904/[g/a]/cattagcaggggaaatcaatgaagatgtgttgaatatttaaaggatca ttccaagtaacc[a/g]tctctcactaaagaaaaacagaagcagaaagtcatacaatctaagataccatgtctaagg/a/ PAK7/p21(CDKN1A)-activated kinase 7/ 1430/8/rs1484645/10038376/[g/a]/gcatcccagtttgttgtataatttcagccccgttactatggtaacctg ctttagtgtcgc[a/g]gcgattgttaatcaggatttgtcgttattcccctttcatcacgaggctctatatccttat/g/ MSRA/methionine sulfoxide reductase A/ 1431/5/rs4426954/160885609/[c/t]/aaggctggcctagttgatataaattcttttctcctacaatttctgag cttttgccttctt[t/c]tcaaaggtacatttgatataaccaacacaggagttacaattcaatgaaagactttctaaa/c /GABRB2/"gamma-aminobutyric acid (GABA) A receptor, beta 2"/ 1432/4/rs7674639/154760193/[c/t]/tataaaggagaaataaaaaatgtcataatcccactgcctacgcagtt 40 acaaatcccattt[c/t]gcttctagtttttatttactgtggtgtgcacattgctttaatagatgcataagggttcta/c /KIAA0922/KIAA0922/ 1433/4/rs6535930/154759506/[c/t]/tgtgctctggctcactttccctccctgttctacctgctgtctccatt gcaggcctgttct[c/t]tctcagccacatccctcctcactgcccagtgcttcagaaggtgctccctgccactctttc/c /KIAA0922/KIAA0922/ 1434/6/rs6917599/20734388/[a/g]/tcttccttgactcactgagttagagttagtctcattgttcagaagccc tcttcctttata[a/g]cttctttttttccaatgcctctgttatatgcagaacttaccttcattgcctcataaatat/a/ CDKAL1/CDK5 regulatory subunit associated protein 1-like 1/ 1435/7/rs7776530/151177796/[c/a]/ggcctctgctgtcccatggcctgctccccacgggcctgtgtcttcca tcttcttgggagg[c/a]tgcagttatgctggattaagggcccaccctgctctaggatgacctcatcttcgctaagta/a 50 (128) JP 2010-88432 A 2010.4.22 /PRKAG2/"protein kinase, AMP-activated, gamma 2 non-catalytic subunit"/ 1436/10/rs7097855/69043380/[c/t]/ctgtctagtttagttggggtctgatcagttcaatgtaatctaggatc aagtatattatat[c/t]cagtctttttttgccccccccaacaaagacacgttacataattcattttcaaactacaaa/c /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1437/3/rs2242301/53242195/[g/a]/atgtgcgggtcagagctacgtagccacagtgtctgggccaggggtgaa ggtggggagggc[a/g]gcttgtgcatactgacccgtgatccctcggcccttgaaggtcttggcaatgatggctgtt/g/ TKT/transketolase (Wernicke-Korsakoff syndrome)/ 1438/9/rs6560293/74379155/[c/a]/gcatgggttgccatcctgactgatcccttggctcagaaacagatatgg tgctatcaggaa[a/c]gcaaggccaatatctgaatattgcagcagagactgctcccatttcagaaagcaacccaga/c/ TMC1/transmembrane channel-like 1/ 10 1439/10/rs617738/84312795/[a/c]/tgcagaaagagaaaaatgggcagtttaggaaacccagggatgtgggga ggtgagtgtata[c/a]ccacgtatataataagccagcaacagctaaagatttagaacatggcatccagatccatag/c/ NRG3/neuregulin 3 1440/10/rs3012064/126723597/[t/c]/ttcagaacggcagctatggaccgaatgcttgtgtaccctaaaattc ttccatgctgaatg[c/t]tggattcgtgaatgtgcaaaccctaatgcccacagtgattgtatctgggtgctgggcctc/ c/CTBP2/C-terminal binding protein 2 1441/12/rs3825260/12387038/[t/c]/tatatccctcaggtgactgggtagacaagaggttgagaatcactggt gttatatcccaac[c/t]ggtatctagaatattgaaaacaaaaatcctattgaaatggttagctgccatcagcatgga/c /MANSC1/MANSC domain containing 1 1442/1/rs2768395/72174618/[g/a]/ggtttgctcttgtgtcttcctcgctagactaaaacttgtagacagcaa 20 cagacaatacct[a/g]tttaaatccatagatatcttataaatgtttgctagctaaatgaatgctttataaaaaagt/g/ NEGR1/neuronal growth regulator 1 1443/12/rs2041149/100634236/[a/g]/cctcaataaagaagactattggaattttccctgctttttaagtgaa attgacctgggagt[a/g]tttaaatttgccttaaatcatatggttgtttttattataatttttccttatgtacacaag/ a/CHPT1/choline phosphotransferase 1 1444/12/rs2041150/100634466/[t/c]/tatatttttttccctctgcatataccgttacctatgtgtgagcaca tgttgttctgtaac[c/t]tttttaacttaacagtgtagtcaactgataattcaataatggaagtaaaggtaaaaataa/ t/CHPT1/choline phosphotransferase 1 1445/13/rs7330977/101535664/[g/t]/ggggaggaaggaagagctgagctacaaaattaatcagctccaggta tgtgccaggcattg[g/t]acttaatccaagttcattgaatctgaaaacaatcctaaaatgaagattccctcaccccaa/ 30 g/FGF14/fibroblast growth factor 14 1446/17/rs1622075/72397244/[t/c]/tacttcagccagctctgcagcaaagtctgttggaatccagaacatgc ccctgggggccga[c/t]ggctgccctggggtggcactggctgaaagaggcccctgacctgccaaccacacgcctctc/c /MGAT5B/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransf erase, isozyme B" 1447/12/rs7314150/102737861/[a/g]/ttcttgcaaaactgaaactctgtacccattaaaaaactcctcattc accccagctttccc[a/g]gcaactaccgctccactttctgtctctatgaatctgactattctaggaacctcatagaag/ g/NT5DC3/5'-nucleotidase domain containing 3 1448/11/rs621313/88553311/[c/t]/ttctagagagtattaaaattgaacacattcatgaagagagaaaaagga aaaagttctgct[t/c]gacaattaataagtaattaggaaaataatactcatacagttgtggatagcatctggtatt/t/ 40 TYR/tyrosinase (oculocutaneous albinism IA) 1449/5/rs4975648/1521287/[a/c]/cctggcaagctgtccccgcgttcacaccctcttcccggggctctgcctc taccccatgga[a/c]cgggtctgctccaggctctggagaccccatcctcaccctccactctccctcccctgggcc/c/L PCAT1/lysophosphatidylcholine acyltransferase 1 1450/4/rs2048398/91733907/[c/t]/tatatattattgttgtatattttccctgggtgttatattcatattgcc ttcctttacacc[c/t]gaattctgcttggatgcgtctcctctgtgttcttaaaacaagacaggtaattcctattat/t/ MGC48628/similar to KIAA1680 protein 1451/2/rs2112040/45605718/[a/g]/gttctaagatcattcaatgggtaaagaacagtcttttcaacaaatgtc ggtaggactact[g/a]gatagccacaggcaaaaaaaatgaatttgaacccttactttacaccatgtacaaaaatta/g/ SRBD1/S1 RNA binding domain 1 50 (129) JP 2010-88432 A 2010.4.22 1452/1/rs4951247/203863944/[g/a]/ctagaaatcggttccccatagcctcacttaagcggggctaaaatagc ggttttatactac[g/a]gccattaagtatggtggaagcaggcagggattccctgttatgtctcttgagtttacctga/a /ELK4/ELK4 1453/1/rs2269340/109973759/[c/t]/caccttgggccagggccactagacctctgacccacctgttgcctgga ctggatgggttct[c/t]tctctgcccttggagctacatctgtcacccctcacagccagtaatctacccctgtccccc/t /AMPD2/adenosine monophosphate deaminase 2 (isoform L) 1454/12/rs1026372/32859457/[a/g]/aggctacagaggactgtatgagccatactaagatgtttgaacatcat tcggaaggcgatg[g/a]agagtcatgaaagggtttaaatctgaggtgtggaacataatcagattaaattttacaagg/g /PKP2/plakophilin 2 1455/5/rs26953/59850071/[c/t]/aagctgacaattcagtatcctcttctttcctggttgctttatagcccact 10 cttagttgtt[c/t]tctttctatatttcctacaatttttagctgtgaggctgtgtattcgttgcttaaaaattc/c/PA RT1/prostate androgen-regulated transcript 1 1456/11/rs2422180/36134310/[t/c]/agtcctttgctttcgttgagaagaacgtactgagtggaaattgtata acctcatcaacag[c/t]taagcacctgaagggataaaaaagaccgccagtagttggcagtcttggttgaggcttcaa/t /LDLRAD3/low density lipoprotein receptor class A domain containing 3 1457/9/rs992886/112181830/[g/t]/taactgctgctgttgagaaaaattggacacacaaagatcaaaggtttt ttgtcttctgat[g/t]caaatgttgaaggtgagcctgttttaaacctaaggaaagcagtctgtaggacaccaagaa/g/ SVEP1/"sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1" 1458/5/rs2950849/90430381/[g/a]/aagctctgtcagcacataccactcgctttgctctaagcacttagatga 20 acatgcaggcca[a/g]actttgaaaattggttcctagttgttcatacaaaatgtgcatgtccctttgtactccgcc/g/ GPR98/G protein-coupled receptor 98 1459/4/rs2168521/25449887/[g/a]/agcacaggcagctcaataatgctttccaaacacaggacattcaaaagc cagtggccaata[a/g]ggtgtttaattttctttaaagccaaagtctgagaataaaaactcgattttctagcagata/a/ KIAA0746/KIAA0746 protein 1460/4/rs4690912/159891509/[g/t]/gaaatatgtgaaatccatgaaaagaaaactataaaacattattgtgg gacatgagaaaag[g/t]cttgtaaaatggagagacttactggattcctgggtgagaagaatcagtatggaatggtat/t /LOC201725/hypothetical protein LOC201725 1461/17/rs1045794/1587459/[t/c]/cccgggacaggcggtggagggcagcgtcctggtcagctcctcctctga ccattccttgac[c/t]gtctggaaggagctggagcagaagcccacccatcactacaagtcagcatccgaccccatc/c/ 30 WDR81/WD repeat domain 81 1462/17/rs2070862/1595044/[t/c]/tggcgggcgtggggatgtgagatgggaacagagctttctgtccctgcc acaggaacatgg[c/t]gctgctctgggggctcctggtgctcagctggtcctgcctgcaaggcccctgctccgtggt/c/ SERPINF2/"serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epit helium derived factor), member 2" 1463/1/rs2577127/218417374/[g/a]/ttctttgtccatttggtgaggtcgtgtttccctgaatgttctcgatg cttgtggtagtac[a/g]atggtattgtgcattgatatattaggtatgtactttagtcttcacagtctggctttgttt/a /RAB3GAP2/RAB3 GTPase activating protein subunit 2 (non-catalytic) 1464/8/rs2685358/27822394/[a/g]/gcaacattttgctgggagactgttgtcttctaagtgatggaagaaaag gaaatagaggga[a/g]aaaggtgtctggttatttattttaggaattatacctccaaaccatctgcttcctaaatct/g/ 40 SCARA5/"scavenger receptor class A, member 5 (putative)" 1465/7/rs3735315/148610582/[g/t]/ctttctgtttcctgtttgcactcttcgctgccttttctgcattcctg acttctaaaagat[g/t]ccttaaggcttaagggatgccatatttttgataaggcctctggtaggtaccacagccaag/t /ZNF783/zinc finger protein 783 1466/2/rs12463674/179140431/[g/a]/gtgttctttatttcacatctagcagattcttcaatttccttatctc ctcttaaccactca[a/g]tggtaggtaggggctttccatggacatcagcctcaagtctgaatgtttctccagcattta/ a/TTN/titin 1467/1/rs4575150/232232679/[t/c]/atggattagccttccacagtgctgtctgtgctgctcactgttagttt ggatctagaggaa[c/t]aatgaacctgtttgctggggatttatggcatcattagagatcaccagagaagaagaatat/c /SLC35F3/"solute carrier family 35, member F3" 50 (130) JP 2010-88432 A 2010.4.22 1468/5/rs1061837/150541530/[t/c]/aaagccctggagggaatcacatgtgtactttttcatgaagctttttg caaagcacatctg[t/c]gatacactagtttattgaactaatgtccaggagtagacatgattggtggccaagttattt/t /CCDC69/coiled-coil domain containing 69 1469/6/rs9371342/154801956/[t/c]/ttactcaagtgtcaccttctcaaggaggcggctctaggcacgtatct caaactgtactcc[c/t]ctcactccttcctgtgcgccttccctccctagcattgctctaccttaatataaccacata/t /CNKSR3/CNKSR family member 3 1470/5/rs26956/59826742/[t/g]/atggactgaagttagatatagagcaactcatgtctcttttagttgctggt gattgcaaat[g/t]tatctccatggccaaattgcttttgaggcactatatgtgatatttatctgtattgtggga/t/PA RT1/prostate androgen-regulated transcript 1 1471/9/rs2567714/116003882/[c/t]/ctctttcaactcagttactccagggtttcatgactgacctctgcctg 10 aataatgctgcaa[t/c]gatgtgaagctttcatcccagggaggcgcatctataaggggatctctccttgagtggctt/c /COL27A1/"collagen, type XXVII, alpha 1" 1472/9/rs2298260/21019330/[t/c]/aaaaaaactgtttcggagttttaccttttccaaatgaaaagaatctga ctgtcatatttg[c/t]aaatatccaagagtggccacagaactggattaagtaatagatgaaaagatacgcattctt/t/ PTPLAD2/protein tyrosine phosphatase-like A domain containing 2 1473/14/rs4761/23711366/[a/g]/atacacaattaccaggataactgagacgcaggagatgggcgcccctctct gtggaccctc[a/g]gtggatccgcacgccacgtgatgcgtcaaacttgagacttctgggttgggttccaggttg/a/RE C8/REC8 homolog (yeast) 1474/22/rs2238810/44291040/[a/g]/agtgagtacttttgcttttcttaatgaattagagcaagaatgaatga atgagtgaatggg[g/a]acattcaaggttatccccatgataacacggttgtcactcctgatgacttttcctctggtg/g 20 /FBLN1/fibulin 1 1475/13/rs4772250/99325710/[c/t]/acaaacagtaatacatccctcctcccaaaatattgaaagcccatcat tttcataggtgtc[-/t]gattgctgctcgcacacctttcatttctgtttccaaatgcaaggctttacaaaagaaata/t /CLYBL/citrate lyase beta like 1476/12/rs4759454/129391808/[g/a]/acgtcttttggttctgcatccagttcaagcacttatgtgtgggttg ttaccgtttgtgtg[a/g]aagactggtaccaccctaccttccaattcctaattctctgtttcagcttaaatcttgtta/ a/PIWIL1/piwi-like 1 (Drosophila) 1477/12/rs1489418/127632745/[c/t]/tgaaatgaaatcttattgttgttttcatgtgcatttccttaattcc cagtggtatgaata[c/t]cttttcccaggtttaatggcaatttttatttcctttccagtgaattgcctgttcatagtg/ t/TMEM132C/transmembrane protein 132C 30 1478/12/rs2373016/98420463/[a/g]/gaggggtagatttggtacttgaccttgagttgtctaacttgtgctct taaacactatgct[a/g]tagtgctgcattttactaggggatgaggtggggtagatattaggaatcaaatactgaaac/g /ANKS1B/ankyrin repeat and sterile alpha motif domain containing 1B 1479/12/rs7952778/24099576/[a/c]/aatatggcaggggtccctcacagtccttataactgatagaagtctgt aataataagctac[a/c]ggtcaacagtctataggacatggcaaaaaagaagtcaatgtcatacctcaaattaaaaat/c /SOX5/SRY (sex determining region Y)-box 5 1480/11/rs7929532/88778642/[g/a]/aacttgcatggtaaagattagtggccttagattgggagtacttaagt atctcccaacaca[a/g]taatgtcagtctgcagagctgggactgaaagcccagttagtctgattccaaagtctgtgc/a /NOX4/NADPH oxidase 4 1481/1/rs1339965/244617484/[g/a]/ttgtgtttagaaagaaatgtaatattttaaaagtacctggcttcctg 40 gagtttacagtct[a/g]gcataaggacaattaatctgacaatagaaagcacaggatattaccagaacacagagcaga/a /SMYD3/SET and MYND domain containing 3 1482/12/rs2592296/116769202/[c/t]/gtaggcactcaggaatcccttacatgtagatagcatcaaattagga ctctcgcttacgag[t/c]ggcagaaacctgatgcgaacgcgcttaggcgcaaatggctccattcattcattctgtaaa/ t/KSR2/kinase suppressor of ras 2 1483/3/rs1534166/135019757/[g/a]/ggtttttctaaaaattctcttgaaattgttgggaattgttttgggga agccaaaactgtc[a/g]taatgttatttgtgaatcagtcttgttttatttttaacagtacagtccaagtctcccgtg/a /SRPRB/signal recognition particle receptor 1484/13/rs7991286/76580509/[g/a]/cacttaggaaaagcgtatcatttcagggtttgtgatggctgagacaa aaattctgagcat[a/g]atttgatgggtatatatcttaggccttagaaagaataacttcaaaatataagagacaggt/g 50 (131) JP 2010-88432 A 2010.4.22 /MYCBP2/MYC binding protein 2 1485/6/rs2239797/36369648/[g/t]/caggtggtggggctgtagcagaggagcacgtctcctgctttacccaga gtatgggtcccc[t/g]gcacacagagccctgggagccccagtctcagcgccactaagatagtggagggaggatcag/g/ PNPLA1/patatin-like phospholipase domain containing 1 1486/2/rs12329322/71610940/[a/g]/aggattaattcttccacttgacacttgggggaattcacgtcctgaga ttgttcttatttc[g/a]cattcccaacatggaaggtatttcgatggtggctagaaccaagaccgacatgccttcaca/a /DYSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)" 1487/7/rs2633387/129614991/[c/t]/tccatccagccaagataagcttaccagaaacaaacagaaattacatc aatcacaaggaaa[t/c]aagactgcagtcctaacaaccaacaagacaaaaatggtcagtatttaacctccaagaact/t /FLJ14803/hypothetical protein FLJ14803 10 1488/18/rs4435332/29920866/[a/g]/ggagcattttcaaaatttacaaaagaactgtcatatgtggcaattgt cataactaagaaa[g/a]cagagctaattgaaacacatacaaacacatacatatactaggaatgaacttacatgctat/g /NOL4/nucleolar protein 4 【０１８８】 略語 NCBI; National Center for Biotechnology Information、 SNP; Single Nucleotide Polymorphism 【０１８９】 〔実施例３〕TNF阻害薬群のDAS28CRP有効性判定に関連するSNPの探索 Human Hap 300 Bead ChipならびにHuman CNV 370-Duo Bead Chipに搭載されているSNP がTNF阻害薬群のDAS28CRP有効判定の個人差に関連するか否か、フィッシャーの正確確率 20 検定で解析した。 有意水準0.1%において407SNP（120遺伝子）がTNF阻害薬群のDAS28CRP有効判定に関連し ていた。また、有意水準0.1%∼1%の範囲でも1409SNP（818遺伝子）が有意に相関していた （表１５）。 【０１９０】 〔表１５〕 整理番号/染色体番号/NCBI_SNPリファレンス/染色体位置/SNPの種類/配列/TNF阻害薬治療 有効SNP(DAS28CRP)/遺伝子シンボル/遺伝子名 1489/1/rs6679498/209779313/[t/c]/cctgtcctggaagcacatacaccaatacaacacctcctaacaagcaa gtcccattcagtc[t/c]tcaagcaaagttcagctcccactctgcacctctgcgacacccttgccttcacgtgaatgt/c 30 /-/1490/15/rs10518754/52145747/[g/a]/aataagtaaagagttatagattgattaagatgatagctaatgcttt tcctgtcttctagc[a/g]tgatggccagcagcctagcacataataagagctaagaaatacaagctgatttctttttcc/ a/UNC13C/unc-13 homolog C (C. elegans) 1491/1/rs12405445/14604606/[t/c]/gagaggaagcgggagaggcaatgggataaacactctggttctagagt ccaaaagacctgc[c/t]tcagcacttcctagctgtgtgtcatttgggcaagttacttaccatattaatcagcatcct/c /-/1492/1/rs2147333/17519113/[g/a]/attttagccaagtaagattcatattttggacttctgatcttgcaaact ggtaagtaataa[a/g]tttgtgctgtttgaagtcactaagtttgtagtgatttgttacagcagcaatgtgttatat/a/ PADI4/"peptidyl arginine deiminase, type IV" 40 1493/13/rs9319110/84510389/[t/c]/acacttgtgaagacagatatgtgttgtaataattagaaaagccatat ttacattgattaa[c/t]tggactatatttgacaaatagataaaaccacttatttaatatcagataaatctaatctat/c /-/1494/4/rs4513549/153845564/[t/c]/caggtaaccatcaccaccaaatcaagatagagaacacatccatcacc cccaaaagtctcc[t/c]tgtgccccctcggtcatccctccctcctgcccttgcctgtcccccattcccaagaagcac/c /-/1495/13/rs9319107/84509744/[c/t]/aataatatagtcgtacactagttcaaacattttatatttcctcaaat gtttcctttaagt[c/t]ttactgattatgagcataaaaaccagttttactcaaatactgtatgacatgttactatca/t /-/1496/4/rs2391037/127459584/[c/a]/taaacttgttttccttttatattttcatgatcgttttattataaatg 50 (132) JP 2010-88432 A 2010.4.22 ggacaatctggga[a/c]aacatttcatgactctaattctaattcatgtcttgttattatccagtcctccattgttgt/a /-/1497/12/rs4128893/94647740/[c/t]/aagagaaaagctgaggttactgatagatatctgacttctggtgcaca aatcgtgtctcca[c/t]ggtatttcatttgtgtcttgccaattttgtaatagctggaagcatacttcaatttgtcct/t /NTN4/netrin 4 1498/5/rs3913348/20983113/[g/t]/gaatgcaatacccattgcaacaccagaaagttttttttgtggatattg gcaaattgattc[g/t]gaagtttctatggagagacataagacccaagatatgcaacataataataaaagagaagaa/t/ -/1499/7/rs314300/100212023/[c/t]/tcactgtcactatttgctacttcatcgctgggcatcattagttcgtcc tcttcctcatca[c/t]tgaagttcccacacatgccgcagacctggcgggggagagtggtttttcggtgctggggaa/t/ 10 ZAN/zonadhesin 1500/16/rs4786026/5355972/[a/g]/gagcaccagttatctttaagaatggtcagtttaggggctggtgtgaag gatgaatcgtac[a/g]ttgtggaagcagaggcagtgaattagaaggcagtccaattaaagtaacactggcagcttt/a/ NPM1P3/"nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 3" 1501/10/rs7897274/68446763/[t/c]/caaaataggggatttctaattagttcacataaattgtatctactgaa taccttctatata[c/t]gagaagaacctagacacttggctaggtgcaggtgtctgtacaaaaattaatgagccaaga/c /LRRTM3/leucine rich repeat transmembrane neuronal 3 1502/19/rs8107048/15591767/[a/c]/gaggctaataatcctcactaaaaggtggtaggagcatgtaatggact catgtctctgaca[c/a]ttagtaggtggtcagaaggagtcaatttccacatttttctcacagaagccctgtaaactc/c /CYP4F8/"cytochrome P450, family 4, subfamily F, polypeptide 8" 20 1503/19/rs3764561/15585294/[a/g]/aatgaagagggagaccctccaagggcagccatgggatgcggcaccca gctgcgcaaaaat[a/g]cacatgagttcttcttcctttgcagttcatgctgagatcaccaacacatgggaccacaca/g /-/1504/15/rs934192/52182570/[a/g]/ggtagattttgtcctctgtgactgaagttcattgtctggcagtttctg agggtacaaatc[a/g]gggagagaaagccctctttctgcagtatttttctcagaagtatttgtttcattccgatca/g/ UNC13C/unc-13 homolog C (C. elegans)/ 1505/22/rs2001136/25711136/[g/a]/tccagaatatgagtttctggggcctcggaaaggaaacagctatttat catgcatcattat[a/g]caccctgctgtctgcagatacttcagtgttactgcaggggattctctgaatttctccgct/a /-/-/ 1506/12/rs7969151/52445544/[a/g]/gtattctctcaagtatcattcagacagaattcaggacacagaaagtt 30 cacaggtgtggga[g/a]gatgcctgataagcagtcagttttgtggggtcattctcagaagactcctgggagataagc/g /-/-/ 1507/3/rs17632548/178765503/[c/t]/gcccacctgcttttattaacagaaattctaatatgtctctcttgga cctcctgtcaacgc[t/c]gatttgtccaaaatgttccaaaatctactcagattaaagagtgccaatccctgatgctct/ t/-/-/ 1508/10/rs2394319/68464762/[a/g]/ctgcctgaaatatgcccacctatgtctatactaggaactcttggaag gccccgttcagaa[a/g]tcacttatttcaagaagcccttattgaggtcaccagttagaagtgctcactgtattttat/g /LRRTM3/leucine rich repeat transmembrane neuronal 3/ 1509/1/rs943918/14598636/[c/t]/tggttacgtgactgaacccagtacacgcccccaggtgactcgtgagccc atctcaaagct[c/t]gggattggtcctaatgggtggctggctgcttgcctgttactgagagagtcctagatgtct/t/- 40 /-/ 1510/1/rs6677660/172281130/[t/c]/ttgctcagggaaactgatttaacaccttttcttttattgggagctca tctttattctagc[c/t]ttttatttagaaattttcaagtacacataaagtagatagaattatataataaaaacctca/c /-/-/ 1511/1/rs6695327/172328467/[c/a]/tcatcctcctccttgccaccaacaccccctcctactgcccaaaaact ccaggcaacaact[a/c]ttttgatttttatcactatagactagttttactagtcttaatcttcacacaaatagaata/a /-/-/ 1512/1/rs6689285/172286356/[g/a]/tgaaagttcatgagctgaaatattgtattttctttcatttcttctag atacctacaggag[a/g]agaaaacaaactatgtttgaactgagaaggaacaaaagacctgtttactctgcaaactag/a /-/-/ 50 (133) JP 2010-88432 A 2010.4.22 1513/11/rs2511188/77598578/[c/t]/cctcctcccccacttcttccttctccgttctctcctccttcccttct tcctccctctcta[c/t]cctttcctcctgactgctctgcccaccagcttccttggagtccaggccttcgatgtacag/c /USP35/ubiquitin specific peptidase 35/ 1514/14/rs917063/70717825/[g/a]/ggcaggggaagtccgcgatgcacgtgtgaccatgcgggggactagcct gaggatgaaact[a/g]aggcacagtgagggggtgaacgaacccgggacctcagaggtctcgctgagctgccgtctt/a/ -/-/ 1515/5/rs1363602/169539456/[t/c]/aacagatccatgaagagggaggctgagagactcactctgtgtcctcg agtttgccctgac[c/t]gactttatggagattccaggagtgactctggtcttgtctgggtcatcacagggcattttg/t /-/-/ 1516/9/rs1892263/93727422/[t/c]/ggtctcgtgggcttgggctgagctgttgggatggctgaaggctgtatc 10 ttgggggaagtg[t/c]gttcttgagagctgtgtaagttaatgtctatgagatgagcagatggttggtgtcatgagg/c/ ROR2/receptor tyrosine kinase-like orphan receptor 2/ 1517/15/rs4965881/99841659/[t/c]/tagggacttcttaacatgggcctgcaggcacctgcctccagcggtgg gcttcagatggtc[c/t]agaagcaccatgcggtaggtgtaccatgtgcatctcccttttcttttttctctcttcaat/c /PCSK6/proprotein convertase subtilisin/kexin type 6 1518/4/rs17057610/173106767/[g/t]/acacacagacatacacacacactcactgagttgacatgacaataaa aaaagtattcagag[t/g]gcgtccaaaaaggaattgagaacaagaatctagaaaagtgacccaaagagtcctggcagc/ t/GALNT17/polypeptide N-acetylgalactosaminyltransferase 17/ 1519/9/rs1029372/135468263/[g/a]/ctgcagccataagacgttctgcagttgattgactgagcccagcaaca gcccctttgatcc[a/g]ttttcactgaacctgtgtccactcaactccagatgatctgtgcaggtcaagatcaagccc/g 20 /-/-/ 1520/15/rs4965392/99843069/[t/g]/cctggcgtgtatctttttttcttagtgatttatagttttcaaaataa tctgtgtactaat[t/g]tatttgttatatattgtaaatactttcctggtctattcttgctttttaactctgttagga/g /PCSK6/proprotein convertase subtilisin/kexin type 6 1521/12/rs1057190/42434526/[g/a]/gctgtccaccattttgtcaacaaaaagtttggaaaccttgtggaaac caaatctttttct[g/a]aaatgaattgcagtgctggtaatccgaatgtggtggtaacagtaagatttcgggaaaaag/a /PUS7L/pseudouridylate synthase 7 homolog (S. cerevisiae)-like/ 1522/11/rs2450129/77618033/[c/t]/gtagaacacaacctggcaagttctagaaactcgaagctgctcaggct gcagcaagcacat[c/t]agaaggcagggctgagagaagacactggaggccaggccaggactaaagggaacggggagc/c /GAB2/GRB2-associated binding protein 2/ 30 1523/11/rs1893447/77650830/[c/t]/ccttcagagaattatgtagatctcataattccctaggcaaaactgga gctctttgaatcc[c/t]agcctagccatccacactataccagtttaaggtgcaatcttgtgattattgccgctgatc/c /GAB2/GRB2-associated binding protein 2/ 1524/11/rs7107174/77675584/[t/c]/cccatgatacaaaaatgaaaaattgctgttggattactgacacataa tgcaaggagaata[c/t]gggacatgagtcctgaatatgctattaaagagaaagctttttcaggactgttctaacgtc/t /GAB2/GRB2-associated binding protein 2/ 1525/10/rs1904611/68693313/[t/c]/tggttgccatcatttgttacaagcacctattcattataaaaaaggaa aaacaactcatcc[c/t]tcaagaaaggatttaaagtgataccagaagacctcgatcttccactctccagcctccctg/c /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1526/1/rs1884994/172216905/[c/t]/atgtaacaaatttagcatcaacagcaagattaaatgaatataccatt 40 tgcctgcaaaata[c/t]tttctccttaacttgttgaggtaggtatattgctatcatcccattctgagtcaagttgga/t /RC3H1/ring finger and CCCH-type zinc finger domains 1/ 1527/1/rs643397/61073571/[c/t]/ttcccaactgcacagtcttttccccctttttgattatctaggcatcaat tttatatagct[c/t]atttttcccactggagaaaaattaatgtcccttataagagcactgtttaaatagcccata/c//-/ 1528/1/rs3753563/173189969/[a/g]/ctgtggggtgatactgagcatccacctgtgtgattggcacaatgtga aagaggggaaaag[g/a]gtggaggaggaagagacaggagagctgatatgaaactcttgttatttatgaggtaatcaa/a /RABGAP1L/RAB GTPase activating protein 1-like/ 1529/11/rs2510044/77586662/[a/g]/ctaagctcagccctgtcccctgttccagaggaggagccaccatctag cgccctggccagc[a/g]tggtccagcacctcccattggagctcatggatggtgttgtccggaacctcagcaatgatg/a 50 (134) JP 2010-88432 A 2010.4.22 /USP35/ubiquitin specific peptidase 35/ 1530/11/rs2511175/77652729/[g/a]/gtaaggaaaatgagaacagcttttatttaccaatctaacatatctcc acaaaattctcta[a/g]aaagtccaacattgtaactgaaaaaggtctgaattattattgacatgctgttgtgttaaa/g /GAB2/GRB2-associated binding protein 2/ 1531/11/rs4945261/77667908/[a/g]/attatccttccccaaggaagataaaaatcacagaattcctaggttag gatatctagttca[g/a]gaatgactggctacataatttgcagagcccagtgtaaaatgaaaacgcagaacttcctgt/a /GAB2/GRB2-associated binding protein 2/ 1532/11/rs4944196/77686379/[a/g]/aggaggtcatggctggaacacagtaaacaaaggggaaagtagaacaa gcaaaaggcaggg[g/a]tagattgaagtttagattttatcttaaataaaatccctcaataggggcatgattaataaa/a /GAB2/GRB2-associated binding protein 2/ 10 1533/8/rs2667995/57115654/[c/t]/ctgaagcaatccccctgccttggcctccaaagtacctggggttacagg cacacaccaata[t/c]actggcaagcaatatattgtggacctttgcagcataaacctgtgttgttcaaaggtcaac/t/ -/-/ 1534/8/rs7386256/37563694/[a/g]/tctaaattttccacaaaatgcattattggatttttaatgtaggaaaat tatgagacctgg[a/g]gacaatggactcagatgtccaaatgttctgacgtttaccggaggcttcagggcttagagc/g/ -/-/ 1535/4/rs6817588/33247446/[g/t]/aactaagaagctagactctacttcagaagagaatagagtcttgtatgc ttctgagcagga[t/g]aaatattataatgccattaggtctatctagacaaataaatttggcattagaatgacaggc/t/ -/-/ 1536/15/rs1562253/99911601/[g/a]/aaccttattcccagagacagtaactaagtcatgccatggggcaaagt 20 gggctttgcagac[a/g]cagttgaagttcaggagcttgagatggggtggtgatcctggattttttcaggcaaaaaca/a /-/-/ 1537/1/rs3753472/201398156/[g/a]/aggagaggtagacagtgatagccctagacaggagagagggaggagac ttctagctacaga[a/g]gtgggtccctcccctcttctctcctcacccctcacccttctgaccacccagagcccccgg/a /ADORA1/adenosine A1 receptor/ 1538/3/rs2360255/144599573/[t/g]/tgtgagtgatatcttgaaagatccttagaagcaacaacaaagtttgc aaaattgatgata[g/t]gtacctacaacacaattcattcaaaacatgaaattctaatggttgattctgaactacccc/g /SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 1539/10/rs10997565/68625276/[a/g]/acacctaccatacaggactttacttaatgtagctttataacatgtt ttaatatcgggggc[g/a]gggggcgggtaggctccacctcagtggtctccttgctaatgttattttttgcatttaaat/ 30 g/CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1540/10/rs4746673/68605706/[g/a]/taattgatttcctgaagatcattcctttttcacagggcctcgttgct ctgccccatttat[a/g]aaaaaattccttaattatgttatacatcagagaagatgaactaggtctaaccagtcatag/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1541/10/rs7073720/68552611/[g/t]/taagaaaaggcaatgtgagttacaggagcatcggtctgatgaggcca tatacaggatatc[t/g]taccatcaatattcctacctaatgtgtcagaattgtacagctcttttttaaaaagccaca/t /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1542/8/rs7006668/16870090/[t/c]/acgagatactagaatttctaaaactaaaaagactgttcatgtaaagca ctgaggaggatg[c/t]ggctagaactcttgcacaatgttcttttcaatgtaaaatagtatagttgctgtggaaaac/c/ -/-/ 40 1543/8/rs10088047/16867426/[g/a]/aggatactgtctagccacttgaccgcaagttgtctacactgctcccc ttctatcctaaaa[a/g]gatctgtgactgattctgatcaatcacagaagaaatagaacttttgggtatggatttccc/a /-/-/ 1544/5/rs7715469/155095493/[g/a]/cagcacaattcccagatgaagctcttgctgaaaacgagagaagcaga cctgaaattattt[a/g]ctgatcgggcaaactcctatagtcaagggtgtttgttggagagcatcttggcaggtccta/a /-/-/ 1545/3/rs9810902/2856134/[a/g]/aatggcaagttttttgcttttaccaaaaaaaaaaaaagacagtgggaat cacaacagaaa[g/a]aggtcggatgctgttggtgatttttgtacctctgaagcttctaaatatagaggggtttat/g/C NTN4/contactin 4/ 1546/12/rs11168967/47985919/[a/g]/tcctatgtatgtatcagggattcaccccattatacaagagactctg 50 (135) JP 2010-88432 A 2010.4.22 ccacaaatcttttc[g/a]aataatctcatttctcttccgcttagatgactgaggagactcactagtcacatgccaaaa/ g/-/-/ 1547/12/rs7295247/47984140/[a/g]/tgggcaacagaatgagatcctgtttcataaataaataaaaaaataaa tacatagaaaaat[g/a]aaaaggaaatatctcacataacagagagccagaggtagggggcaggctctgaggttggtt/g /-/-/ 1548/8/rs10503814/27510492/[t/c]/ccccataattctaattaatgtatatcattaagtgaatcacactgact ttactctgaattt[c/t]cttgacagccatgctaaaatacttaccttggacataagctaagctttaagtttgttgttt/c /CLU/clusterin/ 1549/8/rs11997323/23150340/[c/a]/ttattcatgggggggaaggtgaagtgagagcaggcacattatttggt gagagtgggagca[a/c]gagagaaaggagagagatgctgtaacctttgaaatgactagatcttgcacgaactaactg/a 10 /-/-/ 1550/10/rs4746675/68622064/[a/c]/ttataaaaatcttcttcttctgcaaaaaatcttctgcaaagcaaagc aaacaaccaaaaa[c/a]atgaaaaggcaacacacagaaagaatgggagaaaatatttgtagaccatgtattcaataa/c /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1551/18/rs593234/27933920/[t/c]/agttctcaaatcaaaaccttgagcactttccatgaacaagacacttca ctagagctgcaa[c/t]tattcttgtgtgatgtatcagaaatatttgtttgtatctaccctttgacccagcaattcc/c/ RNF138/ring finger protein 138/ 1552/1/rs6681053/15207369/[c/t]/cctcggctgtaagtctgaagcccaggctgccagagtcgtggaggaaag agttttcccaag[c/t]ggatgagtggccagaagtggcaggtgttacagtggatcctgctggactctgcaggtctca/t/ RP1-21O18.1/kazrin/ 20 1553/14/rs1979352/97257678/[a/g]/tttcaaagaagtttttctgactctttcatattaacacaggctcttcc tctgcaatggacc[a/g]aatgtttctgtccccatcccccaaagttcatatgttgagatcctagactccaaagtaatg/g /-/-/ 1554/3/rs7613869/28631678/[c/t]/gcagctaataagcagggctgcacctagccagtgtggcactgtgtgcaa attagagaaagg[c/t]tctcactccagtgatggcttggctggcagtgcacagtaaggcttttgacccctgcttgca/t/ -/-/ 1555/6/rs10499303/155656931/[t/c]/tactatttttaacatatgggtcccaactaacctagctccatttact cacaagtcagccct[c/t]gttgatccctgtcagcacctctgtcagcattggtctggttagatacatcatataagcatt/ c/TFB1M/"transcription factor B1, mitochondrial"/ 1556/5/rs4700447/61174493/[a/c]/acccacttgaagattaaacctcatacacttctgagatcaggaaggaaa 30 gttgaacacaca[c/a]aagcatgctactgcttttctcctccattttctctctctcctaaaattcagttccatttgg/c/ -/-/ 1557/14/rs6575340/93093725/[a/g]/agagaaaggaaaattctagacagaaaatcacaagctgcctgacataa cctaaacatttcc[g/a]ccctctgaatggtagagatggagagagagtacccccatatggtcacaaagacaatggagg/g /KIAA1409/KIAA1409/ 1558/2/rs12622011/76452095/[g/a]/ctgcagtttgtttttagggagacatctgttaaactcaacagcataga acttaacagaact[a/g]gttaagaacgtagcttaggaggatggtgtttccttacttgaggaaccaaggatggaggat/a /-/-/ 1559/9/rs4877950/87530274/[t/c]/aggatggtagggggctaatgaacatcagcctctccctctcaaattacc tccacaaacctc[t/c]ccataggcaccgccaactacctgatataagcaaaaaagctctacaagtgtaatggaaaat/c/ 40 AGTPBP1/ATP/GTP binding protein 1 1560/11/rs2291842/5676243/[c/t]/ggacaatgaggagcagagagagctgcaaaagctggaggaaggtgaggt gaatgtgctgga[t/c]aacctggcagcagctacagaccagctggtccagcagaggcaggatgccagcacgctcatc/t/ TRIM22/tripartite motif-containing 22/ 1561/1/rs1048635/117456381/[t/c]/tgctcagccttttaaagctgcaggcagcaccacttgagatttccaga ggacccagacctt[t/c]gttcattctaaagagactgatagaattaaaaacaaagtgccttatcttgcactggagttc/c /TRIM45/tripartite motif-containing 45/ 1562/5/rs10051893/174034227/[t/c]/agaaagcgtttatttcctttctgtactttttgaagattaagcacac gcttgtgagtcagg[t/c]gtcaactcttcaaatcttctgttttttagcagtgtaattttgggtgagttactaaatctt/ c/-/-/ 50 (136) JP 2010-88432 A 2010.4.22 1563/3/rs4681946/57051079/[g/a]/accacccccgagggctgatgtggccactaaactgaaccagagataatg acatgagcagcc[g/a]agacattaggtcagttaccaaacagtgctctggtcagtgtggacacagcagcgcacctgg/a/ -/-/ 1564/3/rs4680766/28628633/[g/a]/gtttgtttgttttttgctttttttttagagggtatcgatgtagccaag ttaaaagtggtt[g/a]ggctctttcagtgttgataaaacacagggtatcctgccaaaagtctgtagaaaggagacc/a/ -/-/ 1565/2/rs7591446/45687580/[c/t]/agtcatatgttataatgcctctggttctaacatccgcttagaagagga aataatctctca[c/t]ggaaatactaaaggggttgtcacaaaagggaatatgttctcccagcagctatagctcaac/t/ SRBD1/S1 RNA binding domain 1/ 1566/19/rs2287887/7733955/[c/a]/gctcaaccatgtcatgagtggaggagtccttctccctgtcaaccccag 10 accatcccccaa[a/c]acctccctgaaattcctgcaaggtcaggccgatctcaggctctgactcctttcactagcc/c/ CLEC4M/"C-type lectin domain family 4, member M"/ 1567/18/rs6506520/7617956/[a/g]/gattccaaataagaggccctgcacaaatggagattctgatgtatgcag ctctctacctgt[a/g]tctatttgaaaacaaaaagccaccttattttgtctaaaataatttgaagaatttttagat/a/ PTPRM/"protein tyrosine phosphatase, receptor type, M"/ 1568/13/rs12874394/86652479/[a/g]/tttttttttttagcctgctttccctggttggaacttccaggacact gtttaacagaaggg[g/a]tgagaacagatttgtttgtcttgctccagatcttagggagattctttccatgtttcatca/ a/-/-/ 1569/7/rs4588783/102827171/[t/c]/aaggttctaatgccatgtagacaagactgaggaaaagaaaaggtttg aaggtattgcttc[c/t]ttgtgagctacgccagccagttgtttccacagctagaacttgttgttataatttggatca/c 20 /SLC26A5/"solute carrier family 26, member 5 (prestin)"/ 1570/15/rs1437543/59255759/[a/g]/cacatgtgttcaaacactctcttcttggtagatagtcagactatttg gtgttccttctgc[a/g]aaccgccctactgtcatttaagtaacaaactctgttgatacaggagtggcctctaactca/g /RORA/RAR-related orphan receptor A/ 1571/11/rs6592772/77693211/[c/a]/actcgatttcgccaagggccaggctcccaaggcaagaatctagagta gaagtcacattac[a/c]atcttagactctggagagacaaagaagaaatatttttcctgaagtttcttaaccaggctc/c /GAB2/GRB2-associated binding protein 2/ 1572/9/rs10761134/93686804/[c/t]/caaactcattactctcttggatttttggctggaactggagctaacac atcctgcgggctg[c/t]catacacattcaagactcttcccatccacagaccataacatgtctccatttccagtttgg/t /ROR2/receptor tyrosine kinase-like orphan receptor 2/ 30 1573/11/rs1196043/64644136/[a/c]/ggccggacttggtaacctaatcacatctgtgattggatatagtgagg tttcagtgttccc[a/c]aaagttgggttacctctggggctgattcagggttctcttctggcaactgagcctcccagc/a /FAU/Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed / 1574/11/rs1706937/64640440/[t/c]/tccctagctgaacgggttaccctggtcattaataaagctgtgactgg tcagccctgttgc[c/t]tgtttctgagggatagctattgtcccaccagaccccagattcctgggcccacaagccact/t /ZNHIT2/"zinc finger, HIT type 2"/ 1575/11/rs3850947/64597441/[t/c]/tattatcatttgcctgggatcacacagctagaagctggcagagccag gattcaaacccag[c/t]tggattgcagaacctgtgctctttgctttcaccagggtggggcaggtggggaggaaaggc/t /-/-/ 40 1576/9/rs4837752/122096458/[a/g]/tttttgaacaggcttggatgagtgtctttgacctgagtaaggagtca gcccagctagatt[g/a]tgggcagtcaaaggaggagaggaacaggtgaagtcctacagttccttctcagccaccacc/g /-/-/ 1577/3/rs6800399/33256297/[a/g]/tgaccaagatggaccactacagtctatctacatgatatatcaccacaa aatactttggac[a/g]gaatagaaaaaccacctgaaacctaaacgtagacaatagtagatggagatggccattatt/g/ -/-/ 1578/6/rs9296557/9632180/[g/t]/ggaataaaaatgtgttataggttaaatgaattgtatagatgagtctgac caggcttttga[g/t]atatgtattaaacgttcaaaaggaaaacatgaattctacttattttttaaaacttgtaaa/t//-/ 1579/4/rs12502141/54466283/[t/c]/attatcccagcctcttcaatctccttaataagatctctcaaaatgga 50 (137) JP 2010-88432 A 2010.4.22 acacactgtctcg[t/c]gtgcctataagggatgtgcaatgcctcttttgtgcttttgttcactcttatctgatgttc/c /-/-/ 1580/9/rs4466467/125202042/[a/g]/tcaaatccacattctgggcctgagctcccactcgggaagaaacgatg ctagcccaagagg[a/g]cctagaaatcaatgggtgctccaccgcgccccctgctgactggtgtctgacccacagcct/g /DENND1A/DENN/MADD domain containing 1A 1581/9/rs12341785/125208464/[t/c]/tcatctgtggggtgattgtgaagcccggatacagggaaagtccccc caaggggtctggta[c/t]acaatgggggctcaataaatgctcatcctgctcctctgtgacctggatgtcccttcttgt/ c/DENND1A/DENN/MADD domain containing 1A 1582/8/rs1689888/16885043/[g/t]/cgtaccactgcactgcagcctgggtgacagagcaagaccttgtctcaa aacaattttttt[g/t]aatctcaacttattctaaagaactagaagtgtcatacgggatcccttctctgtcagtagg/t/ 10 -/-/ 1583/4/rs3212153/110828930/[t/c]/agcatcttccatgttaagttcctacaaacagtccaacagtcatcatc agacccattcaca[c/t]acaatcacattaatagaataacagatgttactttcaaggttcaattcttattaatatgat/c /CASP6/caspase 6/ 1584/15/rs4965520/96525461/[a/g]/aggtatgccaacacagtagtgtaatcctaatctttattgtgttagaa agttcctcaagac[g/a]tagatggaagtccataccccaggagaattactcataaaaatgaaatttcctgttttcaaa/g /-/1585/14/rs12587387/24791556/[t/c]/tatatgatcaatgaaaacatgaaacttgttttaacaaaatcagtaa cagggagtaacata[c/t]gccaaatgtgtgttggagaaaacaagaaccacgggacccagaaaaggagagaaattgaat/ c/-/- 20 1586/14/rs1952500/24625196/[a/c]/aggcactgttgctaggtattgttgattcaaatttatttagtttttta gaattgtaattat[a/c]gtgtttggaatagttactaagctgctattatgtgcacggtattgtgtttaagtgtttctg/c /-/1587/12/rs874682/4845492/[c/a]/acttaaactttctgagcatcagttttctcaagtaaataataataccacc tagctcacgaa[a/c]gtctccctttgctgataagacttgaaaaaacaagtctcatacagtgcctgtggatgccag/a//1588/8/rs2976044/57149291/[c/t]/aagcttccggaagctgcctttctccagaagtggcagaccatttttggc ttattgttcttt[t/c]tcatgtatctaataataggcttttaaggataccggaaaaacacccgtggagccggaggtg/t/ RPS20/ribosomal protein S20 1589/15/rs1867147/73150410/[t/c]/gaaggaatagggccaggctgtgcttaggggagcctttgaagtcaggc 30 gcctggtgcagaa[c/t]gctctgggagaggtcagaatgcatagcttctcacctggagggtaagacctccttggctgg/c /-/1590/1/rs11808039/61076141/[g/a]/ggatcagctaatgctatttaccttccgaacccctcctttttgaatat gcatgtcttttgc[a/g]gttatcctttcctaatatcactattgtatgtggggtgtgtgagggaaagagtctttgtct/g /-/1591/10/rs7923028/82345175/[a/g]/tgttttcacatatgtttatgctgaagcccactaggtaaagaaggtgt gagcagctggccc[a/g]ggtgaggaaagtgagggggcccatggtccctggtcccctgaatcttccccgcttcaggga/g /SH2D4B/SH2 domain containing 4B 1592/12/rs10880565/42432515/[c/a]/aagtcacctcacatccacattctccctcaaattctttccaagttcc aaggctgaatgctt[a/c]caaagtaaatatcacgtgtgctttactgaccattatatcccatccactggcagacaaatg/ 40 a/PUS7L/pseudouridylate synthase 7 homolog (S. cerevisiae)-like 1593/6/rs4711930/49660494/[c/t]/aactatgccttaatactaattatacaattttgatttatattaatatat gcagtgcttgat[t/c]atagacatatatcaatcacaactgcttctgcaaccttagatgttacaaacataacctact/t/ -/1594/8/rs1404764/83922203/[a/g]/agaaaacatgatgaaaaatgtgaccccaacaagtcaaggagaaattta gtcttaaaaatg[a/g]gatgtacttccaagttaaagcaatgtgtgagagaaagaaagagagtgagagagagaatga/g/ -/1595/10/rs7099157/68672493/[t/c]/ttcatgcaatatatgtgcctgaccttggaagacctcggaaagatagg aaatgcatgtctc[c/t]gggcctgatgagcctacaataagccaaaaggactgaatgaggagcaactccaaggcagga/c /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 50 (138) JP 2010-88432 A 2010.4.22 1596/6/rs980414/9666446/[c/t]/tgcctcaagccatagaccacttgaatctggctaaatggatgccttactat ttatacataa[c/t]atgaagacccaggctcaatttagaaacctgcaggctataaggatgctgaaaagtaaagga/t/-/ 1597/8/rs1721078/16875305/[t/c]/cattctctattacatcagatctcttcatggtggtgaatatggccaact atgtctgaggct[c/t]acagttacctcatcttgtttgccatggggcctgagttatgacatgtggtactctgaaagg/c/ -/1598/4/rs7687544/92783113/[c/t]/aaacttggaactattagcacttattattaattattattaaccactaac aaaaactctttg[c/t]tgtaggtggctgttccatgcattgtgggatgtttagcttcatcttgtaatctacctactt/t/ -/1599/11/rs2292572/77730512/[t/g]/accttttcatgatgataccaaaggtctaattccctcacttgtctctc 10 tattgctagcctc[g/t]cctttgtctcagttactcctctcttcagggatcttcttcatcccaccacttctcaaaatt/t /GAB2/GRB2-associated binding protein 2 1600/13/rs2806974/52557931/[c/t]/taacagaaaccaggagaagggaataaatgaagcatagcaaatagaaa acaccagctataa[c/t]ggcagaaatgagttctaacagtgtgaacaatgaggccgactctacatactgacattggtt/t /-/-/ 1601/14/rs765034/97285394/[g/a]/gttgaaatcagactccaagggatgaaatagatatttattggaagaaac atcatttattga[a/g]cacctattatatgcatcatgttaaggtcccatgttagaggaaagttaaattgcaggtttt/a/ LOC100132612/hypothetical protein LOC100132612/ 1602/11/rs10899469/77695961/[c/t]/tacaacctctacaacctcatgtgcacctagagtcctagaagtgggt cctttgcattattc[t/c]ctaccaaaggaatcaaaactctctggaaaggggttgattctatgttgtgaagttaaaaaa/ 20 c/GAB2/GRB2-associated binding protein 2/ 1603/4/rs10028838/148690782/[g/t]/aacaatcggtggctcacccttggacactggagcccgcctagactgt aagaagaactgcct[t/g]ggaattgtatatcctcctccacccccaccacgacctatagccaatgacttactggtgtgg/ t/-/-/ 1604/1/rs2211560/61038223/[c/t]/aagataagactccttcaagaaaattttatgcaatggttcaatgatgtt ataaaaacttag[t/c]ttctttacattcccagcatattggtattctagtatactagcacttctgctagacagaata/c/ -/-/ 1605/1/rs6425310/173238305/[a/g]/tagtgaaaaattaggaaataggaagataaagcttgaatgccttatgg gtagggataaaag[a/g]gaaataaaatttttatatacgtaaaacaaacacatgccaagaaggcaaggaaaattacat/a /CACYBP/calcyclin binding protein/ 30 1606/1/rs6674001/61079865/[c/t]/gcatttgcactgtatttataattctgtgtttgcatgaatatggatcta tttacctcactg[t/c]tgtaaacattcataaagattacatcttttttattttaggtaaaagttttgtttttctaaa/c/ -/-/ 1607/6/rs515077/8125285/[c/t]/attctaaacaggccaggtttgtccttggtgcccttttccaaaggctctat ttggcgttat[c/t]gtccgtggaatttgctaagcaaggcagaaagatggagggctgtaaggatgtgtgatcaca/t/-/ -/ 1608/12/rs1513047/17238712/[c/t]/aggttgctggaacatacacccttggttctctcccctatacatacttt tttattttctaaa[c/t]ggtctggctgagaatttacaaatcgtaatgttctgcttcacttttaaactaaaaattcta/t /-/-/ 1609/8/rs6468553/98446725/[c/a]/ctattttcaaacactggagtccattaagttttgcaacttccaggggaa 40 gttttgaatagt[a/c]aactgcattaattttgatcaatttcagctcttagcccagcagcagctacccgtccctcac/c/ -/-/ 1610/19/rs4801699/61477043/[c/t]/atcctcagggaaaaggaagctgtgaaagggttttcagcaaaggagtg tcatatttaggag[c/t]gtgtgtgtgcatgtatgtgtgtttctgtgtgtttaaacaatgtgtcttgccctcaggaaa/t /LOC729994/hypothetical protein LOC729994/ 1611/10/rs4962728/125998970/[c/a]/ttttgttgacagccacattcaggcatggactgtgcctccagcaaat gctggctgcccaca[a/c]catggacgtaatgaccacagagcatgtattgttgggcactgtcagctgggcacctctttg/ a/-/-/ 1612/14/rs1951716/93076828/[a/g]/tttatcatcgtccttgttatcaaagtcagcattatccagggaatggt gggaagaggagag[a/g]cccagctgccgccgccggttcagctcatgttctcgctgctcagcatggaactcggcttct/g 50 (139) JP 2010-88432 A 2010.4.22 /KIAA1409/KIAA1409/ 1613/2/rs1584201/142725441/[c/t]/attatttcatcacccatgtattaagtctactacccattagtggtttt tcctaatcatctc[t/c]ctaccctcaacctccaccctcccaaaggtcctagtatgtgttgttcccctctatatgtcc/t /-/-/ 1614/6/rs11759269/109747181/[g/a]/gccatagtggccagggcttccaagcaagggctgcctcttcatgcag agatcaccctttgt[a/g]gtcaagattagcttggggctggaggtttttccagaggaagttaggaatggagagtattga/ g/C6orf185/chromosome 6 open reading frame 185/ 1615/3/rs10513201/144621072/[a/g]/tttataataggccccatctacctctaacggtgctatctccttccgt ttctatcagtttac[g/a]tttatctccctcttccccacgtcactaaggataaaaattaccagtaccatccatccagcc/ g/SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 10 1616/11/rs645052/35581444/[g/a]/gaaaaagctcaggtccgttctcacccattcaaattgcgtctcatgctg atacttgactga[g/a]tccctttgactggagaatgttgattggcttaggttatctgagcaaagcatacttatgggg/g/ -/1617/8/rs6992115/40820923/[c/a]/ataggtaattttatgtgtcaacttgactgggctaagggatgcccagag agctggtaaaac[a/c]gtatttctgggtatgtcaatgatggcgttcccagaagagattagtgtttgaattgcgtag/a/ ZMAT4/"zinc finger, matrin type 4" 1618/20/rs6064362/54279203/[a/g]/cagcaagagctgataactttaagcagaagagagaaagatgaaagtga atctatgggcact[g/a]tagtggaagcttgcaagatatgttccattaaaaccctgcaattccgaccagtaggtgttt/g /-/1619/3/rs1813197/150500035/[a/g]/cacttcactttttcgaagggcatctcttaatctatgctattcaaacc 20 attcttttgagac[a/g]cataacctatcattaccccctttgcttttcttcaaacatttactagattcttatttgtca/g /-/1620/14/rs7153837/24542222/[a/g]/tgacaaaagaagcaagaacagcaagatcagagaaaagctctggccag tttctttctaaat[g/a]acctctgagctggaggggaggagaccagttgttaagcctaaaaataaaggaagctgtaga/g /STXBP6/syntaxin binding protein 6 (amisyn) 1621/15/rs11247145/96580265/[t/c]/cctgttcacccacttactggctatgcatgctaggaaatctctgagc cttcccactcaggc[c/t]gcctttggggccctcagttctggcagcctctgggttatatcatcctgcctacacccctct/ c/-/1622/10/rs6480251/68555199/[c/t]/tattcccccaaatctcattttttaaaaaattcattttataaaaaaat gaatcattagcaa[t/c]tgatgttctttccaaatattttagtgcccctaaagcctaaaagtgtatcctagaataaat/t 30 /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 1623/3/rs4072181/135351487/[c/t]/tacaaggctgtatagtaggcaatgaccacctgctactatcattgcta acacaaatgtgac[c/t]gcatcactacctgatgaaagccttttactgaatctacaaagcctccagaacaaagtctta/t /-/1624/18/rs8094859/20991332/[t/c]/gtctgtttaaaaaagtctacgatttagtgtggtcaagtttatgagga atgggtattcaca[c/t]acaaagatagagatgtgattcagtataacttcagtgatcagaaacgggaaagttcaaatg/c /ZNF521/zinc finger protein 521 1625/1/rs961417/48248356/[c/t]/ctcacagttctagatctcttttccagtaatgttatagatggaaatcacc atttctagcta[t/c]aacataaagcattagcccaggagtagagaaacatgagtctttaagagagtgaattcaaaa/t//- 40 1626/9/rs9409872/135448132/[t/g]/gggacctgatgaaggtttccccccctgtatcgctgtgcccattctgc agatgagcaaaca[t/g]cagggaactgatttgccaaggcaatgcagccagcaggaggcagactctcccatgtcagca/t /-/1627/4/rs718913/173052775/[g/a]/tgtgtggtggtggaagaagtgacctggaatattaaaagtcagacagaa cacttagaagag[a/g]ccatatatgatttaattttaattattgttttaagtagtgatgaatttggggactgtaatg/a/ GALNT17/polypeptide N-acetylgalactosaminyltransferase 17 1628/1/rs310178/61033340/[t/c]/tactcaaaggcttcccaaaggacacatctgaaccaagccttgaaggctg agtaagaatta[c/t]tgggattggcctgaaaccacccaaaagattttcattagttcctcattatcttatagtaac/t//1629/16/rs2972284/5008153/[t/c]/tcagtttcctcatctgtaaagtgaggatagcagtgcctacctcaatag 50 (140) JP 2010-88432 A 2010.4.22 gttgtagtggga[c/t]gaaatgagggagtagctgtaaagctttcagcacagctcccagaacacagaaagcgctcca/c/ SEC14L5/SEC14-like 5 (S. cerevisiae) 1630/20/rs2260409/23856856/[c/a]/cttaaattgaaactctgatgagtacttggcatctaaacctgtcccta ccctcccttgtgc[a/c]tcctgcaggcaagtgggctctggcctggcctgaactttgggctgagagtctggactgttc/c /-/1631/20/rs2260365/23858015/[c/t]/cctgcatcacttcatcgaaactaaaggtggattccagcttctttaaa tattgttttctta[c/t]ctaaagcagtagcccttcctaggtccttctcatgcccttggcttctctatttttcagcat/c /-/1632/2/rs3770241/45475131/[g/a]/gtaatcaggcagatagtgatactaatgccctcaaatcctttcctctag ggatacctctgg[a/g]atacaaaaagagaaaaagggaattgttggaggtttgtctataatcagaatggggatatat/a/ 10 SRBD1/S1 RNA binding domain 1 1633/10/rs7923245/73004416/[g/a]/tcccgtcatggaaatggggtagggggtgtcccggctgagcttgctga gcaggaggaggac[a/g]tgggtccctgaggccaggaacagcccagctgggctcctgtgtccacggctttcctgacaa/a /CDH23/cadherin-like 23 1634/20/rs4815184/23185728/[t/c]/ttttgcatttgcccttaataacaaggacagctcaggaaacgtaattt ggcagttcagccc[t/c]ggaagccttattcccaccttcccacctgttctttccaatagctcaccttccccagcagcg/c /-/1635/10/rs2928137/79022558/[a/c]/ttgttcttctatccagatgaattctgaccacgctttgaacacttaca ataatgctggagg[a/c]ccctcagtcttctctttagaggaggcctcacagtcctgcagctgtgcccactgagtgtgc/c /KCNMA1/"potassium large conductance calcium-activated channel, subfamily M, alp 20 ha member 1" 1636/10/rs816855/78967484/[g/a]/acgatggggccagcggtgccaccgagactctgatggctccttaggagt tgttatagtcac[a/g]ataatagattgttctctgtttctcaatgctaggtccattctttaaaatttttttttcttc/a/ KCNMA1/"potassium large conductance calcium-activated channel, subfamily M, alph a member 1" 1637/11/rs10501426/77734770/[a/g]/ttatttttaattttttacagctgtcgagttgattgtcctgggtctc tgtaagcaaactct[a/g]ttctctgtgatgcaattatttgctagtgagaaatttatctcatgggcaacagtgagactt/ a/GAB2/GRB2-associated binding protein 2 1638/3/rs6764243/4953493/[a/g]/ctccactaacatatgttttaacagtgaccttttaaagataatgccttca tagaaaggtgt[a/g]gctgcatggctttagtagtgacatagagggagcatgggaggagaaaaaggctttagagga/g/- 30 /1639/11/rs10899496/77801479/[t/c]/atgtttaatttttttaaaaagcccaggctttaggacaaagctagat gactttgggtaagt[t/c]gcttcccttattatagggctaaattactacattaaaagatcaatggtctaagcatagtgc/ c/GAB2/GRB2-associated binding protein 2 1640/9/rs12343168/21590424/[a/g]/ggagcttagtctctggaagcaagctgactggctcaaatcatagcttc cttgttatgtgac[g/a]ttgacaaattggcctctgtgctacagttttctcatctctaaaatgcgtgccataataata/a /-/1641/17/rs1379395/49516006/[a/g]/tgtatgtgtgtgctggaggtcctaaggaagttaaatgattgaagacc tggggataggtta[a/g]caaataaataggaggttgtggttgaagtagtaggtgcctgaatttatgacataagagata/g /-/- 40 1642/12/rs2522129/119232296/[t/g]/tctgacacccaggctagagtgcaatggtgccatcataactccctgt aacctagaactcct[g/t]ggtaattagaactccagctaattaaaaaattttttttggctaggcgtggtggctcacgtc/ g/SIRT4/sirtuin (silent mating type information regulation 2 homolog) 4 (S. cere visiae) 1643/1/rs6669905/4902573/[c/t]/gccacagcacagacctatgacaagcggagcacttgcaggagcacaggaa gcttactgcct[t/c]tgttcctagtggagggctttttggacagagtaaaaactgtctctgaggatttgggttcaa/t//1644/15/rs1542101/76200071/[c/t]/ctttggggcagtgataccgagtcacagatagcccgcctccaattctc cttccctctgccc[c/t]gcccccacccaggtagatccgattgctccccaggacacagctcctgcattcccacattga/t /CIB2/calcium and integrin binding family member 2 50 (141) JP 2010-88432 A 2010.4.22 1645/8/rs2609982/57659031/[a/g]/caaaagatcccgacagacaaggagtccccaggagatccttaggaactg atcttgcctgac[g/a]actggaggtggaggttcaagtgttcccagaccaaactgagggttgggctgctatttctcg/a/ -/1646/1/rs2744721/22359623/[t/c]/gatcttaccactgtgggaatgatctcgtcatgcatttatttgccttac tgtctgtctccc[t/c]ggctaggaggccagctccgtgggtgcgggggccatgtctgtgcacaggtgtatcctcagt/c/ -/1647/18/rs9955563/73953169/[a/g]/tttcaggaagcatgcacttggcctgttaaccagcactggaaagagta agtcattgctgaa[a/g]tgtatttaccaaggtgggacactggatttattttatttattaggtttttaaaaaaaatct/g /-/1648/4/rs3805288/95669793/[a/g]/ctgagtcaagtcttattttttaggatgtcatagaaagaaaatgtgttt 10 gctttattatat[a/g]cccccaaattaaagtagacataaataacagttacaaaaccaccagactcaagcaagtatc/g/ PDLIM5/PDZ and LIM domain 5/ 1649/2/rs1526638/76445730/[a/g]/tcagttattgctttatattttgagaccacataattaggcacttacaga ttcaggattgct[a/g]tatcttcttggtgaatttatccttttatcattatcatgtgatttatactaagatttttac/a/ -/-/ 1650/2/rs2861683/67690011/[a/c]/cttgtgagggaagggtctgcattcatcacatggcacaaatcacttaca gaagagatgggg[a/c]aagttattactttgtaacttgcagacaccaaagttcaacccagctccttttgtggtttgc/a/ -/-/ 1651/11/rs1981405/77653856/[a/g]/tatatatatatatatatatgtggtatagaaggcccgtttattacata gggtcttagaatc[a/g]catgaatatgaacccacaacattaatgactttagtctaaacgtggtcttggataagtaaa/a 20 /GAB2/GRB2-associated binding protein 2/ 1652/13/rs962320/94991890/[a/g]/attgggcccatttttcccgtctaaaaagtgagtgtggaaaaaaagtga gtgtgtcaaaac[g/a]agtctcaaaagctctgcctagatctagtgatagaggaagtaataaaaaatgcaatgggag/g/ CLDN10/claudin 10/ 1653/3/rs11916040/126743742/[t/c]/catgcagcagcatgtaacagaaacagacttcctgcataaacagaag atacaaaggcagag[c/t]ttaggaatttaaaagtaaaagcttgtaccaaactaccgtaagaaaggtatatttaaaaag/ c/OSBPL11/oxysterol binding protein-like 11/ 1654/10/rs4752275/121039069/[g/a]/tatgtgcatgtcacagatcctcacttccagctggtggatgtaggat ctgaggcccagaga[a/g]ggttggtgacttggccatagtcacacagccacctggatagagatgagtggtgagtggtga/ a/GRK5/G protein-coupled receptor kinase 5/ 30 1655/6/rs13191934/23120048/[a/g]/agtatctccctccagagggggaatatttattgcctgctgcaaaagaa tcaggtttcctaa[g/a]ctcagagtttgtctcctgtaatagggcaatactgtgggagtacaggcatccctctgggcc/g /-/-/ 1656/18/rs2644262/32477564/[c/t]/ttgccagttaaacctatatatcctcgtatcaacaatatatgaattag ttgacttgcattc[t/c]tttcatcacttggtatcattagacttctaattttaccaagtagatagaaaatggtatctc/t /FHOD3/formin homology 2 domain containing 3/ 1657/13/rs17079019/84476990/[a/g]/tgaacacttcttttcatttttacacacacacacacagccctcaggt aaaatccgatctgc[g/a]agataactgcacatatgcggtatagacatgtgaatgtaaccacaaacacacattccacag/ g/-/-/ 1658/21/rs2833773/32632195/[t/c]/tttccccatgactgtgctaccaaagcctctactctgtctactcttgc 40 ctgaattgaatgg[c/t]ggagcccttttagtttttctactacccataccagtgatgtggctaatggctgtcttcgac/c /-/-/ 1659/14/rs1257267/98928723/[g/t]/acattctccgtgcctttcccagacttggcacgtatctcaaacggaaa atatttggtgact[t/g]actttatacatacatatatatatttcattatgagctaccatccagcaagcacctgtgaat/t /-/-/ 1660/4/rs11734226/178397852/[c/t]/attcagttggtatgtttgaaaaaaatcctctgacttcacaaacttg taagccggtattta[c/t]aagataatatgtaaagtgaaaatgtgcctgttgtatgaaagctaactgacttgtctcaag/ t/-/-/ 1661/19/rs7256023/2031051/[t/c]/cacagggcggaggggcgacctggatcacacaccgcgcgtgtgccgggc tcacgctcacca[c/t]gcagggcctgtcaccgccaacaccgttattgtcactgccaggacgccggcaccgtggcag/c/ 50 (142) JP 2010-88432 A 2010.4.22 MOBKL2A/"MOB1, Mps One Binder kinase activator-like 2A (yeast)"/ 1662/20/rs4809401/62208012/[c/t]/cacacgggcagcacgaagcccaggaccaacgtgtagacacggctggc cttgaaccagacc[c/t]gctcgggccacgggaagctcagcccacagcttgggacctgcagctcgttgctgtagacgc/t /NPBWR2/neuropeptides B/W receptor 2 1663/8/rs6994118/98438230/[a/c]/actctaggcatagtcatgtaaaagtcaatcaatcaatacatggattaa agtgtattttga[a/c]tatataacactaagcagtatcacatcctgtgggagcctccaaggtaaaccagtaacaaaa/a/ -/-/ 1664/1/rs7525277/209771940/[a/g]/aatggaaatgagaagttgctgtgaggattaaattaggtaacaaatgc ccggcacatggtg[a/g]gcacagaataaatgctagtgcctctgccactcccttctcatcccacagggctccttgcag/g /-/-/ 10 1665/2/rs1474175/76419858/[t/c]/tttgcccagctagagacaacatttaccattttcttagcaattaagttc aattgccatttt[t/c]ttcctgccttgtgactaagttctcaaataagaaatatgagaaaaaaacatatattttttt/c/ -/-/ 1666/4/rs7665599/147633597/[c/t]/gagctagttagggatggggccaaaagaagcagctaagtcttctgagg tttaatttgttga[c/t]attttcataactccatgatttagtaaattattaagaataagtcttctatttttaagaaaa/t /SLC10A7/solute carrier family 10 (sodium/"bile acid cotransporter family), memb er 7" 1667/9/rs1079783/135452684/[g/a]/acattataatcaaattgcttaaaaccagcaacgaagggaaaaatcta aacacagagccaa[g/a]ggctgcatgacctacaagggctcgaaggtaagaatgacagcagactccttgctggagaca/g /-/-/ 20 1668/5/rs256314/34652979/[t/g]/tgtgaatctagatacaggaaagcaaactattttcttgtagaaaaaaacc aggctatatat[g/t]tagcacctgctcatttcccagcatgtcccagcagct/g/-/-/ 1669/19/rs2286364/2024354/[a/c]/gctcaggccggagagaagcgggatgatggttccagagcgtcctcctcc aagtctccgagg[c/a]cccagcggcggttcgggcaccgggagacccgcggggctctcagtggcacatccgggcggt/c/ MOBKL2A/"MOB1, Mps One Binder kinase activator-like 2A (yeast)"/ 1670/12/rs734148/112690525/[c/t]/ctctgcactagacagtaagttttcagggagcagaaagcaaagtaaaa gtctgtctgattt[c/t]ccccaatccttccaacacctgacacagggctaggcacaaagttttatttccacagtctga/c /-/-/ 1671/7/rs6956840/14559187/[t/g]/gtgacggctttgagatctttgggatgcttaaggcctaatccccaaagg ggaaatcaaaga[g/t]aaagtcaaatgttaagaagcaaatgggaagaacaatacatgaaccagaagaatttgccac/t/ 30 DGKB/"diacylglycerol kinase, beta 90kDa"/ 1672/3/rs310692/4287735/[a/g]/tatagcactttcagtgactttgagtttgatgtattctaggacttagtttt tatcctttgc[a/g]tttcagttatttctaatactaccattaacaaacgtttgtgagacatgtaagtattcagac/g/-/ -/ 1673/3/rs9310725/24006094/[c/t]/taggagagaaaacctccaccctcatccatctgcctcatttccccatgg atggagaattgc[c/t]ggtctaatatttcagaacccaggacacttattcatgggccatgttttagtagtggacaag/t/ -/-/ 1674/14/rs6571751/20840570/[g/a]/acagcccctccatcgtttaaggagcatgcgacaaatgaaaacagagg tgaagtagccagt[a/g]aacccagtgaactgtgagttcttctcatttatcccatgttgttattcctgccactttaat/a /RPGRIP1/retinitis pigmentosa GTPase regulator interacting protein 1/ 40 1675/14/rs2753593/25535330/[c/t]/gaaaattaaaagaaactggtatgttgaatttttcccccctgattgga gtgatgctgcaga[t/c]accccacagaaggtcaccttcattcttctatgttttcatctgcaaggcttcagtgtttgg/c /-/-/ 1676/22/rs4823966/47790053/[a/g]/tggcagctgcaagtttaaataaatgcctcctgctgtctggaaatgcc tcctccttctggg[a/g]ctgtggtcctctctggtgcttttacggcagagtccccaaccattttggctctagggattg/a /-/-/ 1677/9/rs887807/122090618/[c/t]/ccctataaagttgttcaatgacctcttaattttctaactatcttccct tgtaccctacta[c/t]gggcttcagtaaagctgctttctcattgactcccctaaattacaatgcatctttccacct/t/ -/-/ 1678/4/rs6822712/112448443/[t/g]/actatataagcttttatttgtctagaattgtctttacctctccttga 50 (143) JP 2010-88432 A 2010.4.22 tttttggacagtt[g/t]tgctaagtattttattcttgtcagtttatttttccttttagtactttgactatgttttcc/g /-/-/ 1679/8/rs1035189/132751390/[g/a]/gcctgtcctgtctaatgtctattcctttcttcattgcagctttggtg tctagttccttgg[g/a]aaactgagcccaaccactgagctgcttaaagttcccctctctaggcttcttttgtattta/g /-/-/ 1680/8/rs277047/132696430/[c/t]/tagaagacagtgacaagggaacagaaatacagaactattccgttccat caatatgaacac[c/t]cacatccaggaatgggtgctgtttacttttttaactctttgcaagcattatgactttgta/c/ -/1681/14/rs10149128/97247326/[c/t]/atcccctcaatatgaaaacttgaaaaaatttagtaatcgtttgatc gtctcagggaatga[c/t]acggtcttcattttctatgtccaacactacagttatgcaggcgactgaacttctattgca/ 10 t/-/1682/3/rs6550829/24013691/[t/c]/ctttcccatgctagctcattctcatggcagctcagggttccatgcatg agaacagacgca[t/c]gcaaggttttttgaggtataggcccaagaaaatctcaaggccagtccagattcaagaagg/c/ -/1683/15/rs12148619/96620760/[c/t]/tgctaaattcatagacaggaataggcagttgtatgattttctagtg ccacctgtgaatac[t/c]cattatcaaaccactactttgcctacaactgtattccctctcgtattccccaaaaacaac/ t/-/1684/14/rs3814835/91484133/[g/a]/cggggagagaaaagcgtcctaagacttgcattgcacaagctgaagtc tggaattcgcacc[a/g]gcgggattccatcctcttcccccccaccccaccccgctgctccccaccccttcttcggga/a /FBLN5/fibulin 5 20 1685/1/rs11211024/44956893/[t/c]/cctttccctccacaatgttgctgggcctttgattccaaaataggacc acatctgggcaac[c/t]agaggctgcagagggtgggcagatgggattgcgagggctaccttagaagacttagaagaa/c /MGC33556/hypothetical LOC339541 1686/6/rs1962432/1625805/[c/t]/ttctgatccggcaccgtgacctgacttctcacacggaaagcagcgtgga ccttctggcct[c/t]cctcccttgggcgcccagccaggacacgcaaggtcatactgctgaggccctttgagatcc/t/G MDS/GDP-mannose 4 1687/6/rs2814811/1615984/[a/g]/tagttcagtagtgctagagagaaagataaccatctcctcgtgccttttg tcttcagccat[a/g]cttttagttttcattctgcattccatagttccaaacgttgaagtcatctgcaggtcaaac/g/G MDS/GDP-mannose 4 1688/9/rs13295631/136520337/[t/c]/tgtcacttctgagcttcccctgctgagaactggtgcctcggttccg 30 cccagtgacgaggg[c/t]gctgggaaacgtccctgcaggcagctgcttcccacagtgactgtgcctcggagagagtca/ c/-/1689/16/rs1816595/54054030/[c/a]/tgacccctcctcagtccccttcctgggctccacaacatataagatga acgttctgattgt[a/c]tatttctcctcccttctcgttttactcttcatttggtggagtgtgtggtagggataaaat/a /-/1690/17/rs854771/18000917/[t/c]/gcagggtgagggcaacagccctatcaccccactcccagaggcctaggg ccacccctgctc[c/t]tcacatccttcctgactcatcagggaagggagccttcattaggtgagaagagggaagggc/c/ MYO15A/myosin XVA 1691/2/rs6713298/45703581/[t/c]/tcttacagtcatttccagaatctcctggttcatttagcaaataccaca tatgagccatca[c/t]agtaactcaattgtcaagcgcgttggtgccaattaaactgtttttcttttcttctcaaga/c/ 40 -/1692/1/rs2170560/186838019/[g/a]/aattaatctgtccaatcttaaatattatacaaaagtgatatgctttt gcttaaaatatat[g/a]aatagactaacataagaacaactttccaaaatcactaa/g/-/1693/4/rs6851301/141179044/[a/g]/caaacaaaacaggcagcacatcagtatggagagatcctacatggctt ctgatatttttat[g/a]ggtgtgtcttttttctctactggtggcaaggattatatgttttccttccctgacttccta/g /MAML3/mastermind-like 3 (Drosophila) 1694/6/rs997607/132475753/[t/c]/acagcagaggggaatatactgtctctcagtaagtgatactgggacatc tggatatgcata[t/c]agggggggaaaaaaagaaacgactcctacattacatcgtacacaaaaatcaattctaggt/c/ -/1695/18/rs8083585/22341234/[a/g]/cctgtggctagttgctatcattttggacagtgtagtaactttgggta 50 (144) JP 2010-88432 A 2010.4.22 gcaagtaaacttt[g/a]ctagaatttttcttaatatttggaagcccaaattatgacaaacttgaatttcccacttct/g /KCTD1/potassium channel tetramerisation domain containing 1 1696/18/rs52677/47534281/[g/a]/atcactagtagctcattaacaataacactagtccctcattaacagtgtt gacccaattac[a/g]tgttgtacatcccagagacaaataactgtaattgcaactcataagtgatttcataaacac/a//-/ 1697/9/rs1049927/112058576/[g/a]/taaagggagagagcaagcagcgagtcttgaagctctgtttggtgctt tggatccatttcc[a/g]tcggtccttacagccgctcgtcagactccagcagccaagatggtgaagcagatcgagagc/a /TXN/thioredoxin/ 1698/6/rs3024443/6126525/[g/a]/gcaattggtttggtgctggcgattccagcagtgagcaggactcagttcc tgtcctggtcc[a/g]agtgacaggattattgtgcagaggggtctttggaaacaataagtaggggcatttagtcca/a/F 10 13A1/"coagulation factor XIII, A1 polypeptide"/ 1699/1/rs332833/61476951/[g/a]/gagaagacctaagtttggcagcgcactaagttgaggatgagaaaagaaa aaagaaattct[a/g]tcttttctggtgcttttccctcttggtttctccactaaaaatcaatagcgtggtcgatag/g/N FIA/nuclear factor I/A 1700/6/rs6911312/154802976/[c/a]/caaaaactcagaagctactttacttgctctgagcacctttctaagat catgacctcaaaa[a/c]tccatgtgccttgagaacaatggctgctcaggactagagcaaacaactgccacgtgcaga/a /CNKSR3/CNKSR family member 3/ 1701/2/rs7599064/76568629/[c/t]/aataaaagcagtaacagtaaaatgtgaattaaaaataccttctacagg attctcttgtca[c/t]ataaataaaatcgtctgtggaagttcttataagtaggaacattttcaaatatttgttgtt/c/ -/-/ 20 1702/20/rs6117294/6418805/[g/t]/tggctgtttgtatggcgatcatctcccccatttacccaaatatgttct gggcattttgtt[t/g]acccctcacattgtctgtctgtgcgctttaacagatcaaatggcacctattagtatgttg/g/ -/-/ 1703/5/rs4642385/170106088/[g/a]/aaagccttcccctcgctgcatcctcacctccgcactttacaaatcag tgacccaaggtca[a/g]gagagtgacacaaagacgtggaccagcctcctaattcttgattcagtgatcaccctggta/g /-/-/ 1704/12/rs4767631/116796126/[g/a]/ggataagcacagaaatcaagagagagcatttagatacttttatagc tatttgatggagta[g/a]tcttatgtctattcaatctaattttttcaaagtgagcactggatgttgtttgcgtttttt/ a/-/-/ 1705/6/rs4585573/155684939/[t/g]/gtgtaggttgccagtcagctaactttaagacagggaaatgatcctgg 30 attatgcgggtga[g/t]cccattgcaatcacgagtccttaaaagtggaaaagagaattggaagagagagccagagag/g /-/-/ 1706/6/rs721101/155674536/[c/t]/ttgaaaccaaccgactcctaagaacagactggataagaatgcagcact tttctatagtta[c/t]tgaacattgaatatctgaataagcaatactagtttcacattcagaatcttcagtattgct/t/ TFB1M/"transcription factor B1, mitochondrial"/ 1707/9/rs895191/137485733/[c/t]/tcataagtaattcacagagttttaaagggaattctattggtgaaagcc ccacagtgcaaa[t/c]ggagatagttcaagttgcacaagggcttctgggtgcctcactttcactgtggaagaacta/t/ -/-/ 1708/14/rs1667659/42469416/[t/c]/ttcttagtgctgctggcctctgactcccacaagaacaggcactaaga ggctgcaagtacc[t/c]ctaggaggagtctgttgtttcatgtgaggtgacctggactgagaaggtaaactccctctg/c 40 /-/-/ 1709/8/rs16910618/83622301/[c/t]/tgttaggaaacacattgagagttcaggccacctttaagtcgtcttag ctgttactttcca[t/c]tgggcccttttgaatcttgtattcacatgtgtacaagccaggattggccaggaatatgag/t /-/-/ 1710/2/rs1434095/178962576/[t/c]/gttgtcattttctgaagacacttgatgtagtcatgtagatgatcacc accagtcagtaca[c/t]gcttatccaaccctgccactgttataattcaaataagttcaacaggaaaaattagcctca/c /OSBPL6/oxysterol binding protein-like 6/ 1711/18/rs4524008/20935704/[t/c]/aaaagatgaaagaaaatgtaggtactcaaagcacagactagcagaag caaagggaagcag[t/c]agggagaaaacacttacagatttgacccatgttcaaaattttactggatgtgaactcaac/c /ZNF521/zinc finger protein 521/ 50 (145) JP 2010-88432 A 2010.4.22 1712/10/rs11005809/58906633/[g/a]/aagagcataaaggatggaggaagctattttctaaatgattcatgtg gaagcaactcatat[g/a]ctttcatttctttgaccaatgtaagttacatgatcatacctaaactcaaggtatgtaaat/ a/-/1713/8/rs10110943/18656892/[a/c]/attcatgatgtgaccagttacattcatatcaataatacatgctcatg ttagtgagagggg[c/a]agcaatcttggactgttatgacactttaaacatgctccaaacaaggccgggtgcagcagc/c /PSD3/pleckstrin and Sec7 domain containing 3 1714/2/rs4853238/76432083/[c/t]/aatggagaaatggtgatgtttgtcaaagagagaaagtaaactgaatac tgttagcagaag[t/c]agggtaaaggattttgttagtagattgccaaatatcaacaattctctcctccaagtgaag/t/ -/1715/2/rs17033787/67645179/[t/g]/aggttgtctggactgcccttgggaccccagctcctcctttccatcat 10 gttgcggtccaga[g/t]ttcagttcataccatcccagatgatttgggggtttgcttcctcacttcaggcactcttta/g /-/1716/15/rs3743338/34771701/[t/c]/acggaccactagtggactgcatcaagcagtatcctttcccataaaat tttaggtgcgcaa[c/t]tgacgagcttagactcagtggagatgtgtctagctttaacctgacataaagttctgcttc/t /C15orf41/chromosome 15 open reading frame 41 1717/3/rs982953/24486257/[t/c]/ataaaaataagttacccaaacggttttccattctttactcgtacctcac tctttaccacg[c/t]gctcatagtttgttgctcttcaacacttttctctaaataagttaataaaatgtattcttc/t/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)" 1718/12/rs7956773/15212568/[c/t]/acaacagcgagagagttctgcactgagcctaaagactcaatttccat 20 tccagctcaaacg[t/c]ttactggttccaggaccttgaggaaaccctttgactccccagaggtttttcagttttgaa/c /RERG/"RAS-like, estrogen-regulated, growth inhibitor" 1719/14/rs9323685/79924934/[t/c]/taacaagctttctagcgattctgatgcacactcatgtttgaaagcat ctgaattaggaca[c/t]gaagacccaagtacaagcgacagaaaagcaagacagagcacaccgtcttcccctaagcag/t /-/1720/3/rs997828/4303411/[g/t]/ataaaataataagttcaaagatgttttatcagtgtcaataa[t/g]gcaa atgtaaaacattaagatccatcataacaccatcgtagcacagaacacctaacgtac/t/-/1721/5/rs2652130/34027156/[c/a]/acaccccaattctcccattgtctaccatcccttcacagcccacaatct cccatcctgccc[c/a]tgaccctgaccaaggccacaggattaaacaccaatggtttaaggtgagctgtttgctgtg/a/ AMACR/alpha-methylacyl-CoA racemase 30 1722/18/rs9958563/4643942/[a/c]/aacttccttgaagagtgaattggagtttattaagtggacaagggagga tgtagtcaacag[c/a]atgtaaatgatgcaggagagggaagagtcaaggaagatttttcttgcttcaatgtgtatt/c/ -/1723/3/rs3796311/14152252/[t/c]/gtgacctggtcagaggacctggtgttagagctgaggggtgaccagcgg gagacacgccca[t/c]gagagccatggcccaccctcccgggactgggtgccggctggggaagtgagcacagaaacc/c/ TMEM43/transmembrane protein 43 1724/2/rs1864444/217731245/[c/t]/ggtaatccaggcagagcaggaaacctgcaaacgcattggaatattac acccaggacacac[c/t]gggggtcttcaggaagagggtggcatggggagcgcaaaagcatggtaactggcaaatgga/t /-/1725/9/rs10120210/94324803/[t/g]/atgctataatcaaagttaacaataggaagtcttgctactggtgtaaa 40 aactgttgtttgc[t/g]gaattccaagctgtctgtttgatctgtgcttgtgtgaggttgaacttttcctcaaccttc/g /ECM2/extracellular matrix protein 2 1726/9/rs662454/102874693/[a/g]/acgctgtgccacaagtaatgaagttgagagagaaagattaactgaggg aatagagaggaa[g/a]agatgcattcagtagatgctgggcaagtggaattggcagtaaaattgctattgattgggc/g/ RP11-35N6.1/plasticity related gene 3 1727/9/rs632924/102872718/[t/c]/tctaggactaaggattgagcactggctacttcctctgtctgcctggtt catatcttccac[c/t]cgaagtgataccttctcaataacggcctaccctggtttcctcgtttaaatcatgatcttt/c/ RP11-35N6.1/plasticity related gene 3 1728/7/rs2160321/77920543/[a/g]/tactgcagggacaggtgcaatgcaaatacacagatggagaaactgaaa gacttcattaac[a/g]tcatataatctcactaatgatcaactctttaagggaagctctttcttcagggataaaagg/a/ 50 (146) JP 2010-88432 A 2010.4.22 MAGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2" 1729/8/rs7831140/132696340/[g/a]/tataaggcatccagaatgtcctggactgtgggaaagaaaattttcaa agcatagctcacc[a/g]ctaggttttacacagagcaggtgagaggctagaagacagtgacaagggaacagaaataca/g /-/1730/5/rs2162804/63660182/[a/g]/ctctctagcatacatgatgagcatgaaaataccttttctctaacttgt atgctggttcgt[a/g]ggtgtgcaattgggaagggagttagagttgcaggtttaatagataacttcagttgcctag/g/ -/1731/6/rs6921034/156712223/[t/c]/gggcagaagctcatttgcttatttaaaatgctcgtctatcaacaacc aattcccatgtgc[t/c]ttgtactgccctcaggacgttttattctaaaggaagtaaaaactcggactcttaaaaaaa/c /-/- 10 1732/13/rs677532/106994363/[g/t]/ttttatcatcaattctatataaccaattttttaaaaaatctacctgt ggagtaggggtga[t/g]gtttacagtcggaacaacaatctaaaagtcaaaacataatgtattttgatactcaaacat/t /LOC728215/similar to transmembrane protein 28 1733/2/rs6732490/67714314/[c/a]/attgcttaacactctggaggatacagagtgcagtaccaaccctcatgg attttttagttt[a/c]gttgatgaggcaagacacagacaccaaaagaatatgcaaatataaggcagaataagatct/c/ -/1734/11/rs1129195/64639365/[t/c]/gtcaggcaggaggctgcaacccttgaccttgaccaccggttcacact ctctcaccagcta[c/t]tggttactacatcttccgtggggcgaattcccagaaaaacactttccgaaagaatccttc/t /TM7SF2/transmembrane 7 superfamily member 2 1735/8/rs1996190/83633749/[g/a]/cacttttaactttagttaaatgtcagattttttaaatttaaggattaa 20 ttttactttcag[a/g]tcttcgaagaagctttgacattatctgaagcttcctatgaggtgaacttcgaaaagtaga/a/ -/1736/18/rs2957176/32483557/[t/c]/tcacagagccacagaaccactggttttgtagaaatacctgagcatgt tttcattagagaa[c/t]tgcactttttattgaaatcctaccttcctaaccacactttatggaaaaaatcactggttt/c /FHOD3/formin homology 2 domain containing 3 1737/16/rs4783960/50405883/[a/g]/gtttagtacctaatcaaacttatgggctttgagtggtgaacagaact tcaacccatcagc[g/a]ttcaagtctatttacctttgataaaacaccatttcctctttctaatgaagaaaaaacaaa/g /-/1738/22/rs5746775/17930343/[c/t]/tcaaagtccagctagttcaatctcaaatacagggtaagcctttgccc actcccatcacca[t/c]gtgggtttatggcttaggactctttaagagaacaggtgggatgtgctgcctctgaattcc/c 30 /-/1739/2/rs1427588/137208796/[a/g]/ttgatcagtttcataatatgaactaggaattgctgatcacagctgac atcttttatctcg[a/g]tggggctcctctcctacaacctcaaaatacctgataggccattttcccacctttataaag/a /-/1740/7/rs7801657/70709832/[g/a]/actgatatattcaagaagccatatgcggtatgaatgcagtgtacagta aatctgaaagac[a/g]agggtagtgggggtggaaagtaaagctacacagtaatttggtggtcagaaacaaatggcc/g/ WBSCR17/Williams-Beuren syndrome chromosome region 17 1741/18/rs628229/4239393/[c/t]/ttttttgccagaacattcaaccatgtcaggccattaacttgctgggatc cttagtactct[t/c]gtgtagccaggtgcactcttgctctttttcacatctagtctctttattttaaaaaacaaa/c/L OC388458/hypothetical gene supported by BC040718 40 1742/1/rs1586059/186781768/[t/c]/gtgtcctggccaggagtgattcccacctggcaccctgagctgcctga gataggctctggc[c/t]acctggaaccctggaccacaatattcagcttactttttttttcttttgttttttttttga/t /-/1743/18/rs4239384/29910347/[g/a]/catacggagcggccaggaggaaccatttctgacatccaccaaatccc tcacattggcagt[a/g]gcctattctacttactccaaaggtcatcctgaatagtgtaaatgattatctaacaatgtg/a /NOL4/nucleolar protein 4 1744/18/rs9961162/29884418/[g/a]/tcttagttaaaaatgtgttgaaataatttactgctataatagataat gttactatctgct[a/g]ttcctttaggactgactacctggacatcgatcatattatatattgtctagcttccccaag/a /NOL4/nucleolar protein 4 1745/17/rs2013868/12053119/[t/c]/ctggcacttctgaatcgctttcagctctgaggcatcgatgtctgtgt 50 (147) JP 2010-88432 A 2010.4.22 tatttcacatcct[c/t]cgagctttctttctctgagccctcaagagtgttgatgactcggtatcttcagttcccagc/c /-/1746/5/rs7701069/174037805/[t/c]/atttacaacctcatccaacctgtttttctatcctaaccctgccactt ccctatatttcag[c/t]cataccaactgacttaccattatccaaataagcaaatcctactataaaattgttgtgcct/c /-/1747/3/rs310709/4315847/[c/t]/cccattaatagggtgtgggggaatcctgaattagaagccttgcctctcag aagctataga[c/t]tttaaggtagctgcctagtaaatattttatcagatatagttgtgtacctatccttcctta/t/-/ 1748/3/rs167463/4314147/[a/g]/tgttttgggtttgttttagagagaaggtctctctccgtcgcccaatccag gctgcagtac[g/a]gtggcacaatcatagctaactgaagccttggattgctgggctcaagcaatcctcccacct/g/-/ 10 1749/2/rs4402741/57625671/[a/g]/acagaatagtgataaaaatacaaacttatatgctgcctcctattgaaa cttccaaagacc[g/a]aaagaggaaaaaaattgtgagggggcttagccaaaagacttactgaggctatacagatta/g/ -/1750/9/rs2472516/106756217/[t/c]/aataccaaataagcaaagatcctatgtgctaaagattctaatattgt gctaagattttcc[c/t]tcagatgtttggctttctcaaattccctgagggctagaactttgccctactcatttgtgt/c /-/1751/10/rs315632/36512617/[g/t]/ctctggatgttgttgtgtgtggacatgatgccttgaactgctgcagcc agtttgcaaccc[t/g]gaagaaccagccttagaatgaacccaatttggaggaaattaattaattgcccctgccgta/t/ -/- 20 1752/2/rs206816/31498487/[g/a]/actaacaaaagtttagttagaatggaactggtaaacgaagttaaatgat gctgagaatct[a/g]tgaaatgacggaagaaacttctgtgtttagtaaaaggcagacgcttagatatttgtgaaa/g//1753/12/rs1476582/46248328/[t/c]/cctagagtgaagattgctaattacaaactccattgcatacttttatt ttttatttggaaa[c/t]attttagatacataaagatatacacaataacatcaaaccccgtacacccaccagtcagct/c /-/1754/3/rs1589287/103892606/[t/g]/ttattgcttcttccttggttcttgaacctatggaataattctgagct gcatcagtctaag[g/t]gttcttcttctgatgaatgtatgcttttgaaggggtgttgatctactaagacaagaaagc/g /-/1755/3/rs1609976/103881839/[c/t]/tgaataactaggaaaaaaagtcaaccactggagaaaagaagagcctg 30 ggagtcatcagta[c/t]acccagacaaactttttctctattctccttctgcagctccaagagactacctggggcact/t /-/1756/12/rs2120576/91754320/[c/t]/ctttttattttctcaccaattgttatctcaatatatattcttacagc gacaatttcccta[c/t]attacgctccatttttcatttgttacttgttcagataatgaaatgaatataaaaagagtg/t /EEA1/early endosome antigen 1 1757/4/rs883617/32994477/[c/t]/gcatttttatgactatcatttaaataatttatctgtgagcatatttttt ctataaattag[t/c]ttgctaggtgtactagtctaatttcacactgctgataaacacatacttgagtctgggtaa/t//1758/4/rs2585942/33000247/[g/a]/agtcaccttgtatgaagcttaaatgtagcaaaaataacttggcaaaat tctgtggagctg[a/g]ggttactttctctgagttttcctcagttttcatcaggaatggatgctgaattgtcaggca/a/ 40 -/1759/4/rs4293771/33037607/[a/g]/tgctttgtacaatagatccttagcaaatgttgtaagcagaggtttgca aactgcctgtgc[a/g]ttagagcttactcttttgataatctcggaaatcttatattaagcataaagtgaaatcttg/g/ -/1760/4/rs1039654/33042080/[a/g]/ttcataacagcgatatgactaattttccaggtaagcacaaaacgtgtc tggagggtgtta[a/g]taagtgcttataaccatcaacctaagaccaaagaatgataaaaatttactagttggactc/g/ -/-/ 1761/9/rs4135168/112056706/[g/a]/agggtgacaggaactttaaaaaaagcactacagcctggggcccaaag gccctgataatca[g/a]ttaatcctcaaaataacaatccaaagtcattgatcgaaagttacactaatttgattgtta/a /TXN/thioredoxin/ 50 (148) JP 2010-88432 A 2010.4.22 1762/10/rs7076647/68683472/[c/t]/gaatgcagagtcaggaggtaaccggcaatgccaataccatgggagat tgtagctgttccc[c/t]gcagtttcctccaatgcagcaacaccaaaggaaatcataaatgaaaaacgatggtgatga/t /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 1763/18/rs7243817/20386492/[t/c]/taggagatccttccagtccgctctcacctaaagccccgatcctgatg aagacatttggat[c/t]tggcccaagcacctcatattgtactgaagcacagggtggtgatgggtttttttgcctctt/c /-/-/ 1764/20/rs6053352/5305902/[g/a]/atgttgaaagagtgggttcaccattatctccatcttttgtatcaggcg gtagatgttggc[a/g]ttgctgtccatagtggccaagctcctaccatggtgctgcttctgtggcacactcaggttt/a/ -/-/ 1765/1/rs6685648/15697782/[t/c]/caagggaagaaatgtgtctggagtctctattcctgacttctgtcttgc 10 aaataccagata[t/c]agaactatagaacaccagattccatggatcttgaaagtgatctttttttttttttttttt/t/ CASP9/caspase 9/ 1766/4/rs10021303/96075704/[a/g]/cctcctacagcttgcctttcagtagtggaagtcacacttaaagtaaa cacacagagtaat[g/a]aaagaaaatcaagacaaggctgatggttctacaaaaaaatgaaacagagtaaaaggacag/g /BMPR1B/"bone morphogenetic protein receptor, type IB"/ 1767/13/rs2497606/24477336/[c/t]/gcttgtgaaggcagcgcacacttgcttccaatgcgatccttgcagct tttccacccatga[c/t]atctgtatttgttttttcaaattttatgtatttttctatcacgaactttgattttttccc/t /LOC390387/similar to Striatin/ 1768/22/rs8139582/45236222/[g/a]/cagtcccctctacccatgaaaaagccaacggcacagatgaacttggt caccccccagaac[a/g]ggctgggggaggtctggctgtgtgcgctggcctggtatacagtaggtactatctgcggag/a 20 /CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Droso phila)"/ 1769/15/rs8029613/94924150/[g/t]/gagaagacagagtgttaacactaacctcagcaagctcatcttgcccc cacaacatgttct[t/g]gcacttgctctctagaggagagtagaacctgttgttgatgcaatgtgtgtgccaaatcac/t /-/-/ 1770/17/rs6565478/76306599/[a/g]/ccctctctaggtaggatgagctttgctccaggttacctgcctttcct taatttactgaac[a/g]taaagttggagttttatgtggttttgcatttttggtttaggataatttttaattcttcgg/g /KIAA1303/raptor/ 1771/5/rs1979833/20989186/[g/t]/ggttcataaagcctgagagacttaagactgtctagttcacactttttt ttttcaatgtag[g/t]atactgagacatggaacatttgtaagagtttt/t/-/-/ 30 1772/9/rs4072799/89677744/[g/t]/gcctcagatcgggtccatgtctgctgcagttacctcaggcgatgacag ctatggggtgtg[t/g]gtgtctctgtgtgtatgtctctctgagtgtgtgtctgtgtgtatgtgtgtgtctttgtaa/t/ -/-/ 1773/15/rs2448928/84920344/[g/a]/aacattggatgactcagaaggaagaagataattaatatttacatgga ctttagcatttct[g/a]catgctaactccatcatttattgactgcactttgggtaaattatttatgcttttaaaatt/g /AGBL1/ATP/GTP binding protein-like 1 1774/15/rs2028548/76226175/[c/t]/ctgagtttctccctcactagatctggagggtaggagtgggtcttgtt cattttttgttct[c/t]acagtgcacttgctagagaatggcttgggaagcctttgtaggattggactggccctcagc/t /-/-/ 1775/16/rs9308366/84567020/[a/g]/ctaggggttggtgagctaactgccagggcttttgtgcgaagaaaaag 40 gtgttcctacaag[g/a]cagctcacagcttggactttagccccacttgagacagaagcactttgtgcagtgcacaaa/g /-/-/ 1776/8/rs2929934/134286887/[t/g]/cctagacaacactctccttgacttacgatcttttctcctttttgcct tcttggcttctgt[g/t]gttggacagaatgatgcaggctccatatgacagtgtgtttgcaaagatcattttctccat/g /WISP1/WNT1 inducible signaling pathway protein 1/ 1777/8/rs12680797/24515385/[c/t]/gtattgggaggccaagtgtggaaagactgttggcatgcattatgttg gtgaaattgtccc[c/t]cctagaaaatcactaagggctgcacagggaggtagacaagcaagacaattattacagcag/t /-/-/ 1778/9/rs7871031/136519456/[g/a]/ggggatgcccattgatttgttaatacagataacgctccctgaacctt ctgaacttggctt[a/g]ttacttctgaggctggcttcgcaggtcaggactacagattctgaacaaatgccttttctt/a 50 (149) JP 2010-88432 A 2010.4.22 /-/-/ 1779/13/rs1543233/86479710/[g/a]/caatagtggtttgttccagcctcttgggaccactgccttaccactaa gaaaggaatattc[g/a]cctataagagttccaactcttgtaatacgttgttgtaatctccgtgaatccctccactct/a /-/-/ 1780/20/rs6040409/11111049/[c/t]/tactgatataccaattttacttgattctgggtttatatttgtaaaca agagtggaagatt[t/c]catgtgagcttgaatatggatgtagtcaggggcatgagcctgatgaattaaataggtcag/t /-/-/ 1781/14/rs10151365/50837158/[t/c]/accatactctgatttgcggggttatgaaggtctacaaattgttaga tatctttctgcttt[t/c]ctcattagacaagccagcttaagacaaatgccaaacaaagcccttgaatttcccagtatg/ c/-/-/ 10 1782/2/rs17012789/76575813/[c/t]/tctgtggactgttgtaaaggttttacagtccacttagagaccactta gtaatatacagag[t/c]tttggatgaatagaaatacatttataaatatcaagccttaaaaagagaaggtaatatgaa/t /-/-/ 1783/2/rs4851333/100534356/[a/g]/aatggccaaggaagccatgataatagagagaagtgacgctgtccccc tagaacctcgtag[g/a]gttgttaaaggcttgcatgtatttatttatttatttatttatttatttatttatttattt/g /-/-/ 1784/2/rs2971007/100549959/[t/c]/ggggaggcgtaagatgtttgcaatgtgtgggagtctgaggggggttt tctcaaaggcagt[c/t]gtactgtctgaattggagtcccttggagtgctggtaaccccacccacctagtgtttactg/c /PDCL3/phosducin-like 3/ 1785/2/rs2946588/100566715/[a/c]/ctataaacaactttgggttaagagctgctttttcccttaagccattg 20 atgacactattcc[c/a]ctgtcttctggctttccttcctgctgttgggaagtcagtaagcctcatcgttactatctc/c /-/-/ 1786/2/rs11678350/100572431/[t/c]/gtttgtgccactgcactccagcctgagtaacagagcaagactccgt ctctcaaaacaaaa[c/t]aaaacagaaaaaacaaagatgaaggcatgagagctttgagagacagaggcagggaaaggg/ c/-/-/ 1787/3/rs2055320/2986476/[t/c]/tgctcccatgtggcctctcagataagccccagtttattagctttaataa ttgaaatcata[t/c]tcctaattttttagccttccccaacaataaaataagaaagtaaaagtctgtcattgttgg/c/C NTN4/contactin 4/ 1788/4/rs10516887/92181500/[c/t]/ttttatttaaagagctgattgatgctttgtctgtactgttctcccac acattatccattt[t/c]ggtcagtgacagttcaaccatcttagaaatggcaaattatgtaagaaaatctcctgtgtt/t 30 /-/-/ 1789/8/rs10112573/78193307/[c/t]/ggtctataaaacagtattagataattagacactgtaggatgcactgt gatgagaaagcca[c/t]agcctaggagttcaggcatgtacacacacatatactataaacacagtggcataaatgttc/t /-/-/ 1790/9/rs10989693/103714550/[a/g]/aaaagatgtttgatgaaggttacttacaatgaggcaaaaatgctgt tttgtcacacattc[g/a]tccacatctgtgtcttctatgtaatctctagtaaagcttatgtagctcactaatgatttg/ g/-/-/ 1791/9/rs872863/125194175/[t/c]/gtggagttcccatgcagatgacttcccgaaccccttctaatgtttggt ttaacgtgtcgc[c/t]ggttagcgcgcgcgtgtgacagtggtgacaggcgaggctgttcctttttaaataccatgt/c/ DENND1A/DENN/MADD domain containing 1A 40 1792/12/rs7963343/92819753/[g/t]/agctttgtgatgtcacactttttgggccaatccaacgtatactttcc acgtattgattta[t/g]gattttaactgcaattcctgtctccctgaaatgtctaaaaccaaactgtaacctgactag/t /LOC100129881/hypothetical protein LOC100129881 1793/13/rs355339/105613234/[g/a]/ataaggagctcaacatatttggtttccaaatagccagtctccccagt gttattgatttca[a/g]tgtctcctttatttgacatggcttatggctggtaagtcaatttttaaactttttggaaaa/a /-/1794/18/rs748317/47512343/[c/t]/caggatccttcaagtttcagcaaacaaagggattggaacatagtgttc acaatttcctag[c/t]tgtctaatcctggaagctaaaatgtatttgcttctaaaataaagggaagagaaccaaagg/t/ -/1795/2/rs1472959/231649204/[a/g]/tagcaaatggcaacatatatgggagggaggctaattgtttttgttgt 50 (150) JP 2010-88432 A 2010.4.22 ttttaatgtttgc[a/g]gcgtattggaagggtagggtaaatattacaacagtggtctgttggacttttggttcctga/a /PSMD1/"proteasome (prosome, macropain) 26S subunit, non-ATPase, 1" 1796/2/rs12694886/231631803/[t/c]/cacattctgttcctttctagtcttctcttcctcagattttccctta gcttctcaatcttt[t/c]gtctcaactcaaatgttatccttccctgatcattctattaaaacacgcttactctccctc/ t/PSMD1/"proteasome (prosome, macropain) 26S subunit, non-ATPase, 1" 1797/3/rs6772591/171997444/[a/g]/aagaagaacaaagttgaagtattcacacttcatcattgtaaaactta gtacaaaggtaca[g/a]taatcaagacagtgttggaataaggatgaaattgagagttcagaaataatctttgcattt/a /-/1798/6/rs3116567/6123327/[a/g]/cctcaggccctccttccctcagtctagcccctgccttgctgccaaagta atatctgaaat[g/a]taaacctgagcctctcccagcactgcttaaaagccccacccccccccccctctccctgtg/a/F 10 13A1/"coagulation factor XIII, A1 polypeptide" 1799/22/rs136796/48217393/[t/c]/tttcctgccatttttagtaaagattacctactgctgcacctcggtgtt tctgctttccag[c/t]gcctggggtgagagtagcgacacggtcttctcgtacgcgtgaggagccagtggaggaact/c/ -/1800/18/rs9676102/27973449/[a/g]/cattttttaaaaagtacttttattaaggaaagaagcttaaattatgt cttttgaaatgta[a/g]accatgtcctcaactgacaagcagcaaactgcagcagattatgaagaagattaagtggag/g /-/1801/9/rs2312735/93645729/[g/a]/acttctcctaaagggctgtgacccccaatcccactagcttgctcgcac ttagaaattact[a/g]tatgtctagagactccacacaactacagttcctccgcatgcatgtcgatgtctgcaggtg/a/ ROR2/receptor tyrosine kinase-like orphan receptor 2 20 1802/9/rs1881385/93636602/[g/a]/gctgacgacgggactggtggggtattttgtcccagctattccatgcat aaggtgtagaga[a/g]tatgtcttctgccatggctagagttaaataaaggaaaattcatgccaggctgagttcagg/a/ ROR2/receptor tyrosine kinase-like orphan receptor 2 1803/1/rs7555212/4902227/[t/c]/aagcacccagacctgtctctgccctggaaccccttccccatctcatggt ggcccaattgc[c/t]tcatgtgttgtgttcttactcctcctgcacaggaaacgaagactcagctgagctttaatt/c//1804/3/rs3804797/3104632/[g/a]/ctgattaatattactactcaccttataaatccatcctttctggaattta ctcctctgctc[a/g]gtttaggatcattagtgaatttaatcaatgtagactttccattttcatcaagatgattaa/a/I L5RA/interleukin 5 receptor 1805/18/rs7505354/63208880/[c/t]/tgatacagttgagaaaaataattgaaatttgatttgattgtattcag 30 gaataaaaagcaa[t/c]acaagtaggaaatagcagtttataacacaaatttattctcagtggtacaaaaaaaatgac/t /-/1806/19/rs1270290/39983838/[c/t]/tttatcagtccttccacctctgtgtggtaaacatgagcaccttctcc atatcacagtcag[c/t]gatctgaggaagttgtccagagtatctcagtctagtgagcaggggcaggatttgaatgca/t /-/1807/1/rs12404648/21881385/[c/t]/actgctctattatcttcctgacttcatcctgtgaatttgactggctt tccctcctacttc[t/c]agatgctttcatgaccctcttacccttagttttttacttactatatcaaacccagggtac/t /USP48/ubiquitin specific peptidase 48 1808/5/rs16885750/55910566/[t/c]/taattaggtactttgctatttaaggctttcaggggcaaacacacaaa aaattgttttgat[c/t]gagttacaaaataaaatcttaaacaaatgtacatagaatactcaagagtttattttaaaa/c 40 /-/1809/4/rs4527530/136158970/[c/t]/gtaacccatcacatcccactatcttatctctgatatcctctactatt tgttctcttagta[c/t]tgggggaacccatccccaatatttcaacgtaggttctttctattttccataagtgttggt/c /-/1810/2/rs971476/79842175/[c/t]/ggagtgaaatttgagctcaagaacgtttgtctttttaaagcataaaagt atttaataaca[c/t]tggcttttgaaaagcccttaaaatgtgcacgtatttgtatgggctgcataaaggaagaag/c/C TNNA2/"catenin (cadherin-associated protein), alpha 2" 1811/2/rs953222/79833475/[t/c]/tgcaaccctgaactgtctttctttgtattataattatggctccttctct tcatatatacc[c/t]tgatacttcttttttgggctggaaacaataagcaagcaggcaaacagttgtaattttgtg/t/C TNNA2/"catenin (cadherin-associated protein), alpha 2" 50 (151) JP 2010-88432 A 2010.4.22 1812/6/rs9480384/150771571/[g/a]/tgagctgactaaacattatgcttttgtgaaattctggactggaaaac gaattgaaaggct[a/g]tttctaagcccatcttctgctcttggaaggaataaatgcaccccacgctgctgcactcta/a /-/1813/6/rs2249437/1540215/[t/c]/caccctgcaccaaaagcccagcctgctctctaggcgttccatcagccgt ccatgctgaaa[c/t]gtccttcaacctcaccgccccctgcaagccctcccgctctccagccgtgcgcaggcaggc/c//1814/13/rs2862901/23933239/[t/c]/caaccccatgactagctagggcagaaaaaagaggctagatacatttt tttctgataacta[c/t]gcagagatcctctcaacatccccaactatgttcaccattctagttgaccaccccatcatg/c /PARP4/"poly (ADP-ribose) polymerase family, member 4" 1815/15/rs1025145/45472598/[g/a]/ccaaagaattgtcaatggcagaaatgtctctctcagggtagtaggaa 10 aacatatatgggc[a/g]ttggaaaattctggtatttcataagcattcacagtggaatctagaacctacattattcta/a /-/1816/17/rs7208502/76284923/[c/t]/tattaatccaagtaagcagaattcccatgtagattcattccacagcc ttttcttgggtga[c/t]gactctgtgcccagaagcaaggggctgactgggacctgagaggcctcttcttagtggcca/t /KIAA1303/raptor 1817/1/rs4839463/115972228/[c/a]/gccatcagatacatgtcttctcccagctggctctatttcttggctga ctgtatctcctgg[a/c]ccccctgattctggcagagctttttgcctcctacctcatggcaaatactgaggcaccttt/a /-/1818/18/rs1075892/42547212/[t/c]/ggggtggcaaagaaagtggggagaaggagacagacccatgaaatagt ttaggaatggaac[c/t]agcaggatgcattgataatttagaaagtgaataaatcaacagtaactcctaggacttcag/c 20 /ST8SIA5/"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5" 1819/15/rs1077918/38991028/[a/g]/agggaactgttacctcagaccagggcagccagggcctcagagacaag gaacagatggggc[a/g]taatggaggaggaccacaccaagagagttgggtggagacatctctggcttggccttagac/g /-/1820/10/rs7914892/3035244/[g/a]/ggtgcagtctcaaatggcctggctattcctcaaaaaagcaaataacac tcttaatctgtg[a/g]atagaagccaagaaatccaaagacattcagacagtgggtacttaatgtacctaaatgtct/a/ -/1821/10/rs10903911/3031749/[c/t]/caccttttcgtttttggaaagatgttcactggtagtgtctagttgat aacccagaggctg[c/t]agcagtgggacaggtgtggagaatcaggcctggaacccgcccgctgggtgggacagtgcc/t /-/- 30 1822/8/rs2667975/57067684/[g/a]/ttgcctttgagcaacctcacaggtagactgttaccatcataatggttg gggaggaagtcc[g/a]gatgcaactcagcttaacaaaagaaggagtaagatgtgcagggccagcataaggagccca/a/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1823/8/rs2667976/57067277/[t/g]/tgaggagattctcttcatcttaggccatgtgattctcttcattataat gtcaggcccagg[g/t]gtgaacaaagacaagaaaaccccaactttctaaaccacctgccgacaccaaagaactaat/g/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1824/8/rs16920176/57061690/[c/t]/tttaaatatgggtatttggtgaagctgtcattttgaaaatcatctct ccctaaggcattg[t/c]gggtccttgcatgctgacagattgactagattttgagcagtcacagaaatctccaccagc/t /LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1825/8/rs7813271/57025705/[g/a]/aaactcaacaccttagaaacagaagagtgagtcctcatgtgttgtcat 40 cttggtggcttt[a/g]tttgccacattggatttcttgttaatattcttcacctttttcttgccgtggaacataata/a/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1826/8/rs7829816/57011940/[g/a]/aattttgaatgttcccaacacaaagaaataatacattaaaaataataa aagcaacaaaaa[a/g]agaaaaagtacagctttgaagccagaccaagttccggttgtacctgagacctttgattac/a/ LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 1827/2/rs843205/156179042/[c/a]/aatgaacttaaacatacagtataaagtatatataaaatatagcaggaa atattgcttaga[a/c]ataacagctctacatattgatctaaatttgaatcaatcatcatttcaggttttataattg/a/ -/1828/8/rs6981398/24540502/[c/t]/cacccactgaattttctcaaaatttttaaaaagatacacccactcatt ttaataggcctt[t/c]ggaagggtagtgcgaggggccttggtctgatagaaggaaggaaagtacataacaaaaata/t/ 50 (152) JP 2010-88432 A 2010.4.22 -/1829/20/rs761685/49373633/[t/g]/ttgttagctttcgttgaaaacaagaaagacaaatccagttgggtgtta ggaaggcaaggc[t/g]cagagtcaatgtgtgtgtggtgtgactttaggatagaggaatagggaccccatggacttg/t/ -/1830/18/rs11081343/7519438/[t/c]/tccagcctgggtctgaggggcctctcatgtgtcctacacaaaggaca aacaagatgggga[c/t]tctggaaacagcctccaccatagcgttagggctgaaacaaatgtctctcactcctacctt/t /-/1831/4/rs2928297/37133996/[a/g]/tagctaggtttcctctccctagactgtgtttcacattcccctagttac acaatttttctg[a/g]taaccctgaatcttgggatcttttacagtcttggttaaatagtaactagtacctatgtcc/g/ C4orf19/chromosome 4 open reading frame 19 10 1832/20/rs764673/41987407/[c/t]/tcaacatgggtgaaagccgtgactgcgtgggtgggcagggtggatgtt gagtagaaacgc[t/c]ctgtgtgtggtgtgtgagtgcagactctattgcggtgtgggatgagcctacgaagtcctt/t/ TOX2/TOX high mobility group box family member 2 1833/18/rs2345035/1575460/[g/a]/gaatataagacattatcacagctgctaacttagaagaaagtacatgta gggatttaagtc[a/g]agactgtattttgattggcttatggaactattaaatggtagaaataaaatccaaacttag/a/ -/1834/16/rs11647781/48151920/[g/a]/atttcaagcttgccacagtatgaagtccagtttgggctatattccc ttccctctcgcagc[a/g]tgatgaaggtttccccgcaaaatcaaaaggcttactgtcaagttttcgattggtctgggc/ a/ZNF423/zinc finger protein 423 1835/9/rs8114/70586059/[a/g]/taagtcaacatttatattttcatcagaacttaataatcccataaataaata 20 gagctctca[a/g]ttatttaaaaaaatcaagggataacatatgtatttagacatattagcagcgtaaagatgt/a/FAM 122A/family with sequence similarity 122A 1836/18/rs9807688/4696001/[g/a]/ccatttgcaaaaagcttctctgcaatcggttacaaacattttatgagt tggggattctct[a/g]gttagcatgtataacagggaagggttagccttgatttatgaaggaaatggcagtaaaagg/a/ -/1837/18/rs7235870/4636261/[a/g]/aaggaggtagggtagtgagagcaagactagggggctgaaagaacaatt gagaggtgttca[g/a]tttttccagactacatgttataatgatcttgggcagtacctaggattgcttttttcattt/g/ -/1838/12/rs7295136/116803517/[a/g]/ctctgggttactttttgttagtgtttgttttggtttgtttgagggt acagagggggcttg[a/g]tgaggaagagacagaaacactacagaccggccactccaaccagctgctcctacctagaga/ 30 g/-/1839/10/rs1867996/72997953/[t/g]/ggcccagtggctgtggggaggtcactgcaggtgacactcacgttctt tccttctcccctg[g/t]ttaagtgttagttgcctgggaggagctgtgtgctgctgtttgtaaaactgacctcagagg/g /CDH23/cadherin-like 23 1840/4/rs7679284/95672069/[a/g]/tcattttttactctcccctgtcagtattctgtaataaaaattatacct aaattattttct[g/a]tgtgctttaaaaagatcctatatgttagagtgaaaggaaaaagggggggaaagcttatag/g/ PDLIM5/PDZ and LIM domain 5/ 1841/1/rs2755244/67257058/[t/c]/gggattctcaagcacagaaggaagcttaaagcctcttgtaggaggaat ggctgagctaaa[c/t]gggttataactgggatgctaatgacagaagctgcactgtatcctgtgagacttcgaccct/c/ SLC35D1/solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine 40 dual transporter) 1842/10/rs7095234/3048952/[g/a]/tctctatgtatccattgacccagcaattcggttccaatatacatgaca gacaaaatttat[a/g]tagatacaaaaggagatacatgtaagattattccatgaagcattttttatgatggtaaga/a/ -/-/ 1843/7/rs854541/94758416/[t/c]/actgctgtgtgttcagcatttcagcaacactggcaaacacaacacagtt cctcttccccc[c/t]acctaacccaagaaattgaacaggaaattgatttttaaggaaaccaccattttcaggttt/t/P PP1R9A/"protein phosphatase 1, regulatory (inhibitor) subunit 9A"/ 1844/6/rs7749023/42169711/[c/a]/acaggctccccaggagactgaggtttgtgtgcagcaagtttgctggga gtgccctcaaga[a/c]gcacactggcatgggagagggagaagtgagcacagggaaaagctgggctgcctgcacttg/c/ -/-/ 50 (153) JP 2010-88432 A 2010.4.22 1845/13/rs415756/110259218/[a/g]/tctcatgtattatatgtgtaattaataggcaaaaattaacaaccatt tatgccaactaca[a/g]acagaagatctgatggaataaaggacaacttttataataacaacaactactcggaatact/a /-/-/ 1846/15/rs727479/49321839/[g/t]/gtgaaaatgtctctggaacatcttcttcactgcttttcttctcccttt cactttgtttcc[g/t]ccatgccccctctttgtcttgtatttatcccttctctttattccactcatcattttctct/g/ CYP19A1/"cytochrome P450, family 19, subfamily A, polypeptide 1"/ 1847/18/rs9966360/3988885/[t/c]/taagatactttgcagttgtttttgtcattatgataacattccgctaaa acaggcaaatta[t/c]tgtgttttacggtcacttgggaatagtccctttggtgctgttctgccacctactggacag/c/ LOC388458/hypothetical gene supported by BC040718/ 1848/6/rs2690110/25436546/[c/t]/tagaaaactcctagccagtcttgacggaccaagccctacactgagcat 10 gtacagagtctt[c/t]ctgttccatgcagtacttgctaacaaaactaatttaaatgccttaccatgactcgatctc/t/ LRRC16/leucine rich repeat containing 16/ 1849/3/rs9816982/7654361/[c/t]/gcacacctgtttgaaacatgacatggagtcattttacacaaacacacct acctgcggaca[c/t]gctcatggcagaccactggccgtagtgacaggttggtcaacctgaacaatggtgttgccc/t/G RM7/"glutamate receptor, metabotropic 7"/ 1850/18/rs12956812/63213185/[g/a]/ttgaacctttctaataaatttgtcagttcatttattacattcttca gtttcaaaatttct[a/g]tttggttattcttacacattctctctctctctttttttttttttttttttttttgagaca/ a/-/-/ 1851/7/rs10246118/97136791/[c/a]/ctgtgctagctgcttcctctgcctcagtgacatcttcccaaagagac catcattttgaaa[a/c]ttagaacactcatccccacctccatggtattccctgttctctctactttgctctatgttc/a 20 /-/-/ 1852/6/rs742341/6486882/[t/c]/aggttctactgtcactttaagttgctaacacagtcacaggtcagaaacta acatatccag[c/t]ccctggcagtagccaaagcccttcgattgaatattaaatctcctctcctcctgccacctg/c/RP 3-398D13.1/hypothetical protein FLJ33708/ 1853/8/rs10808814/78063574/[t/c]/ttttaccaagagtaaaccttctttcaaaactggagtcaacagtctca aaccctgccattg[c/t]tttatcaattaagtttatgggatattctaaatcctttgctatcttttcaacaatgtttac/c /PXMP3/peroxisomal membrane protein 3/ 1854/17/rs4969230/76340856/[t/c]/gtgcctcccccagctgaaagcattctgtttggtggaactggttctga tattttccagctc[t/c]tctcaattatttccaggagcaggcagagcagtgtgtgtacataatccctcatgtgttata/t /KIAA1303/raptor/ 30 1855/2/rs4832316/86898224/[t/c]/tgtacactctgacattatttataaaaaataaaagcacatgccatatat tattcattatta[t/c]gtcattgtttatagatacttacataataagagaatcacaagtataaaaaaagcctggagg/t/ CD8B/CD8b molecule/ 1856/1/rs2182143/67151524/[t/c]/ttccttggctcaagttaagattaacaaccagctggtcttaatttctcc tcacaattagag[t/c]gctcagtgatgatgttgttggggatttttgttgttgtttgttctggtttgaagttgctgt/c/ WDR78/WD repeat domain 78 1857/13/rs9530494/75434275/[a/g]/ttccacttcccctctgttggtaagaaccagagatgaggccccatgta gatagatgtgagt[a/g]ctcctgataaatgactttgcacctgcttgtctgtagcagctccataatgtggaagggcag/g /-/1858/13/rs9544099/75448918/[g/a]/tgttctgcttttcagatatcatgtattgaagtcaaatagtttagacc 40 aacaattttaagt[a/g]tatgtgtggaccaggagtattgatatcacctagaagcttgttagaagtatatgctctcaa/a /-/1859/20/rs1884033/40117008/[a/g]/ctgtctctccatgacccgcctcctctgaccccctactgaggccactt agagatatacact[g/a]tagaaaaggaatcgttttaaagaagttctctagacgacgagttagtgggtgcagcgcacc/g /-/1860/2/rs2270348/67654532/[g/t]/tcctctaccttcaatggaaattgtcatggagaattaagtttttgacaa atctacagccta[g/t]gtgcagggcttcttcctgggtgtaacaataaggaatttggaaactgtctctagttttggc/t/ -/1861/18/rs1808891/27969216/[c/t]/tcagaaaaactattttacaccctttgatactaccaaataacctagat aatcatatgtaag[c/t]tagtcaagtgatttgctaatgttgcaaaataatttttttcctagagacaatagtttcatt/t 50 (154) JP 2010-88432 A 2010.4.22 /-/1862/13/rs1522009/86546539/[a/g]/ttaaaaatgatagttttctagcagtaacttgatgaaaatttattcag ggagtatgtcaca[a/g]ttacattttgttagctaaaatttgaccttttctttcttgtttttttacttttatttcttt/g /-/1863/5/rs2431135/174741914/[g/t]/gctgtgccaccatctcagggattatggtctcaagaaaatcatggcaa acccagctcttaa[g/t]tcagggtggttttccctgtccacctgctctttctgctataaagaggcccctggggaacac/t /-/1864/13/rs1965154/23970200/[t/c]/gcctgagctaagacaacaggtaagaagaaaaaggttgggaggtcggc tgattcattgaaa[c/t]gagttatgaacagaggtcagtaaacacataggaatcaatataaacagcattacctccatg/c /PARP4/"poly (ADP-ribose) polymerase family, member 4" 10 1865/11/rs10836429/35606649/[c/t]/aaactcaaagttaactaggtgtcctgttatgtcttgttttttgttt tgttttcctaaatc[c/t]ggtgacttgacacacagaagctttctattttgtaatttgagattgtaaactcatgttcaa/ t/-/1866/10/rs2026628/6749664/[t/c]/actgtagaatagttatagcaaaataaaaaaaacttttgtgacactctt aattttcgacat[c/t]ttagaagaaaaaaactgatagatttttttatagcaaataagcatcaggtcattacacaaa/t/ -/1867/13/rs7328804/72717135/[t/c]/ggcaagggaaccagcacagagaacctcacctgggctctagatgcctc ggctcagaaatca[c/t]acctgtcgctttcgcttcacacttcataggccagcacaagtcaaatggctatgtttaatt/c /-/1868/2/rs2861688/67691978/[c/t]/cagtggaaggatgtgttcatttatcaatctataaacatgctcgatgtg 20 agcatgtaggga[c/t]acccaacgaatacatcatttctaggttttggatggatctcatgcctccattcccatcatc/t/ -/1869/1/rs1336775/176231201/[g/a]/tctgggcgacagagcaagactccgtctcaagaaccagactttgagtc taggtctagtatg[a/g]atcaagagcttgaacttttaatccctgtttatacttcctcccaagtcagcagttcaaaaa/a /-/1870/9/rs913357/88362302/[g/a]/cacaactaaggcagaagcagcccaaggtccccatgtgcctgcacagaca cctcctgctgg[a/g]cacctaggatcttccctctgtttctcccttggaagcatcaactgtcaatgagcacctggc/g//1871/17/rs8075751/16881961/[g/a]/ccatgggaggccctggaaacctgtagcattcacacattcctccagat gaattttattatc[a/g]atgattagcagaaaaagggcgagatgagagcccagctctcaggtgtggagaactgcttgg/a 30 /LOC100128283/similar to hCG1775427 1872/17/rs11078168/13430337/[g/a]/tgttataagtcctacttctgaaacatctaccaaatatttccctcac ttcccatgcatacc[g/a]cactgctctagttcaagcctctatcatcggtcctctagattcctcaacggccacctatcc/ a/HS3ST3A1/heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 1873/6/rs1539604/58476590/[c/t]/aatttggaggtagccggacacaaaatagataactgaaatgcaacccta tcacatataaaa[c/t]actttacctggaaacttgaaaaactgtaaagtgtttctaaaataaagggcattttgatcc/t/ -/1874/6/rs12663198/58404607/[a/g]/tcttgactactagcaagaaactcagggaatataaattctaacttggt tttaacggtagga[a/g]agtacatggcatctcttggcctcagatccctctccttcaatttaagtagggtaatcatat/g /GAPDHP15/glyceraldehyde-3-phosphate dehydrogenase pseudogene 15 40 1875/4/rs524675/13575949/[t/c]/cagatctcctaaagaccaagtgaacagatgacttccaatgattccttcc tcaaaaaatgc[c/t]caggcccttgcctctgtaaccctccctgtaatcattacaatcactctgttgcttccgctt/c//1876/9/rs11103714/136499769/[a/g]/ctcttcctaatctgcctcttgtcagtttaatttgcaggacacagtg gcatcatcagagat[a/g]gcagagctctttcactccatgggaactgctcttggagcccctggccccttgaggggacct/ g/-/1877/9/rs2159994/122114956/[a/g]/ctttcctgtttttcccagaattggcaataagcatcgcaacttagaaa aaaaggttgctac[g/a]gacaaccttagtttggagaccagcccctgtgagctagtggtgctggggcctgtttcccca/g /-/1878/3/rs2054745/197830384/[c/t]/ggaggaagagttgcaaccccaaatttcacaggcttaaagaagtttat 50 (155) JP 2010-88432 A 2010.4.22 gtgcattaaagga[t/c]gcaatcaacagagggataagacaaaccatgagacgggagaaaacatttgtgaatcacaca/c /-/1879/13/rs7140044/23927295/[t/c]/aagaatgtcacaccctccatggaactggagcagtcaagacaaataat cacttcgctctca[c/t]tggctaggtcagggaggtcgacatcgagatcgggttgaaagacaagcatgcaagcctgaa/t /PARP4/"poly (ADP-ribose) polymerase family, member 4" 1880/13/rs7987638/50686054/[a/g]/aggcattgaagcgtttcttgtaataacacttaccatgtggcaggcac tatgttagacggt[g/a]aaagtacagtgataagcaggatagtctggtcttcatggagcttataatttagaggtggga/a /-/1881/1/rs11589503/176213314/[c/a]/gagatgggtagtatttgtccttcaaggaaagtaggtctttcagctc catatagaaacaca[a/c]cccagtattttagagtccagatgttacttcctgatgcatgatacacacagtcacatggga/ 10 a/-/1882/14/rs2287015/75115115/[t/c]/aggagactgtggcgatggtgaatgaaggtcccaaccaggaagagagc gatgacacccctg[c/t]gccggagtccgcactccaagcggaccccagcgtctcggtccatcccagcgtctcggtcca/t /FLVCR2/feline leukemia virus subgroup C cellular receptor family 1883/1/rs7517829/22352746/[a/g]/gaggagaggctgggccacgtgcaaagctggaagaggccagcttgggcc agggaacgaggg[a/g]agagaagccttggaggaggctgacgcttgtggggctctgcgtatatgtgtgtgtgtgcat/g/ -/1884/8/rs4735248/94967397/[t/c]/gttagatacgagaaggaatggggagattaagagggtctagtcagagct ctgctatgttga[t/c]taatcaagccagcacccagtggaggagtacagtaaatcacagtcaacttgaacacaaaat/c/ -/- 20 1885/1/rs10494667/190645602/[t/c]/gtcatggcagatcagagacatcagtagcagatgcaatagaggtaaa ggatgatacctaga[c/t]gaggaaagatcagctggccttgatgatggccaatgatggcagcatacattacatggacaa/ c/-/1886/11/rs697324/35591902/[t/g]/cacctcccaaaggccctacctcctaatgccaccatattgggagttatg atctcaacatat[g/t]aatttatggtgcaaggaggaacacaaacattcagtccgtaacagagatacatacataata/g/ -/1887/5/rs10065919/86138081/[c/a]/taaactgtccagtgtgatcctagggcccaccatggtaacaaagacac ctcaatcacttgg[a/c]aaattgcaaaggcttacaggtcacaccccaggaaccaggaacaaaggccagctaaattct/a /-/1888/6/rs11156103/156697649/[c/t]/cataaaacttagtaatctgcccctgcaacatcccttctctcataag 30 cacaaatgtagtag[c/t]gattctttctattctccaaagggttgcctgtgcctctacaacatcaccttatgttctctt/ t/-/-/ 1889/8/rs17584140/16565719/[a/g]/aagacagagtagacaagtaaacttattcctcaaaagcacggaggccc ccttggagttgga[g/a]atcatttacttgtagtggcacaaagtggcaccaaaaaaatgcatgcctatgttatgttct/g /-/-/ 1890/9/rs885043/1260931/[a/c]/aaagtaagaaccaagattgcagatggcagtgaggcctttgagaccctcag tgctctgtga[a/c]ggtctttcaggaagtgagcctttttacctgagttaagtaggaaccttgtaattgcataaa/c/-/ -/ 1891/16/rs1684617/4696545/[t/g]/ccttggcctcccacaaagtgctggcatcacaggagtgagccacagcgc ccagccacaatt[t/g]tgtattttctaaagcatggcatgtgtttgctatgattataaactgtttcaaatcacttcc/g/ 40 ANKS3/ankyrin repeat and sterile alpha motif domain containing 3/ 1892/9/rs7863795/136532526/[g/t]/cgagaatccatcggaaaaaaaacaaaaaaaagctttctatggatttt caattgtaagaag[t/g]gtgggtgccccgaccccctcgtggttcaagggcagactgtcttttatggagccaccattt/t /-/-/ 1893/4/rs1589559/171931314/[c/t]/gaaaaacaaagtcattatatgaccatttaaagcaaaaggaaggggaa ggatctaaagctg[c/t]agtatttaatgccagcaacgtgtggcttgataatttcagaaagttgtttttcttaaaata/t /-/-/ 1894/9/rs386880/6134333/[c/t]/gacacatgaaaaagaataaaaaacaacttagaaggtaaataaattaatct aaatgaattt[c/t]gactgtataaaacagccccagtaaagttttagggcatacacactgtgtaaatgtaaacag/t/-/ -/ 50 (156) JP 2010-88432 A 2010.4.22 1895/9/rs1566951/75504975/[a/g]/cgactcacactttcctagtacaaaatttgagaatgtttacccccgaaa acttggttgacc[a/g]agcataattacataaaattgatgagactcttataaaccaagtgtccataaacataattca/g/ -/-/ 1896/13/rs9517243/97726512/[t/g]/ttgatgaaatgaggaagcaagatgctaagaacaagacccatttctca attattgagtgtt[g/t]tagagtctctgaaaaagatatttagaagcaccagagcctgctaattttgcctggggttta/t /FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-deriv ed)"/ 1897/12/rs4251545/42466562/[a/g]/aagacaattgaagattatattgataaaaagatgaatgatgctgattc cacttcagttgaa[a/g]ctatgtactctgttgctagtcaatgtctgcatgaaaagaaaaataagagaccagacatta/g /IRAK4/interleukin-1 receptor-associated kinase 4/ 10 1898/18/rs12608075/54088089/[g/a]/gttcacatggttcctctttctagaggtgggagatgtccttttatgg ctcagaggtccaca[a/g]aataaacttgcattcaagcaaggttgtaaaatacctatgcattaagagcagtccagttga/ a/NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like "/ 1899/1/rs17108140/53455266/[a/g]/ttactgcccctggaggcctagtatgagacccaggaagaactcatccc cttcttagaggaa[g/a]cctgccttgggcacctgctccctatgaagctttctgtagacagcagacatggaggctgca/g /C1orf123/chromosome 1 open reading frame 123/ 1900/7/rs314313/100261301/[g/a]/tgtgacacctattacctgagtgtttccaagcaccaggcctgtgctgag cgccttacaaat[g/a]ttaatttcacccatccagcaacgctaagggtggtgctattattgcccccatttttcagat/a/ EPHB4/EPH receptor B4/ 20 1901/11/rs1629709/15164745/[g/a]/tccacatttatgttcctaaattggatattcccacttaggaggtattt tcccatctgacca[a/g]tagctcatctaaacctagatataattattattttgtctgttttctcttcagtacatccaa/a /INSC/inscuteable homolog (Drosophila)/ 1902/17/rs198547/46006810/[a/g]/cctgagaaagagcaagtccccaaggccacctcattctgcctgcgtaac ttcccctggtgc[g/a]gaagagtgggcaggcttggggcgaagcctgactggaggcctgttcccatccctggccacc/g/ CACNA1G/"calcium channel, voltage-dependent, T type, alpha 1G subunit"/ 1903/9/rs10817563/115866663/[a/c]/aaatagaagtgtgctgtatttcactcttttgcaaggggagtcatta gctttggttttatt[c/a]ttgacattgataaagaaatacagatttagttgacatctggattaaaagagcagattgaaa/ c/AMBP/alpha-1-microglobulin/bikunin precursor 1904/1/rs1426173/72157184/[g/a]/caaagttagaaggtcaagtttatcgattaaaacccacagcaatgaaat 30 atctgttaagcc[a/g]gggtaactgattcccatgtggcttaatccacatagaatttttccagatggagtgattttg/g/ NEGR1/neuronal growth regulator 1 1905/2/rs2032953/231744037/[g/a]/agtgccagtccacaactataactgatccacaacaagaagcttacatc agaatgtaaatca[a/g]ctctatcactaagcaaactgcagttcagctgatgttttggggaagactttcttgatgaaa/g /PSMD1/"proteasome (prosome, macropain) 26S subunit, non-ATPase, 1" 1906/4/rs1517945/138157786/[t/c]/aaaaaaaaataggtttcatattttcccatctctattttaagcacctc cttcctctgggtt[c/t]ctatattatggcctatctgctatcatgtaaatccaaagcttgaataaattttatgcatta/t /LOC729578/hypothetical protein LOC729578 1907/6/rs4413610/42176953/[t/c]/tattcatcacccaaagatgccatttgctgagcaactactaagcgctag gcacgtgctgga[c/t]gctttgcctaaatcagtatgtcaccaccacaagaggccttccctgactaccctgttaaag/t/ 40 LOC100128918/hypothetical protein LOC100128918 1908/5/rs2287939/34034640/[t/c]/ttttctcaaaggtggaaggaacagcatatttaagttcttttctgtgga aaactcagaaat[c/t]gagtctgtgggaagcacctcgaggacagaacatgttggatggtggagcacctttctatac/c/ AMACR/alpha-methylacyl-CoA racemase 1909/9/rs4135183/112055423/[a/g]/attgctatacttctatgtaccctgctgcagctctccccatgtctcca cctctagaggtgg[a/g]gttcagggatttgcataactaaaaaatttatgaaagtgttgtcctacctttctcaggaac/g /TXN/thioredoxin 1910/2/rs4954148/134966132/[c/t]/tggcaactgcatgagatcggccgtggttcagcaaaggctcctcttgc tatctgcctctgg[t/c]gacagctgttatatttagcctactatttacactttctcctcttatcatacgctttgtctt/t /TMEM163/transmembrane protein 163 50 (157) JP 2010-88432 A 2010.4.22 1911/1/rs4339837/163790071/[c/t]/aacccacatgaagattttagaactgcacacagtacatgttcaattaa tgctagctgtcgt[t/c]gttgttacaaattctttgcctggcagtgattctgagtgtcacacgagatgcagaggacgg/t /LRRC52/leucine rich repeat containing 52 1912/5/rs890801/177647897/[t/c]/gggcaatcaggacgagatggctacccggtaatttgtcatttatttttt tgctctcttcac[c/t]cttttctcttaaaccaatattctttccctgagccttgatttaactctgtctgcgctcctg/t/ COL23A1/"collagen, type XXIII, alpha 1" 1913/6/rs884366/109680788/[t/c]/attctggactcacttgaaccttttttagctgggccagggcaatcccag aagctgatttat[t/c]gtatttatacttccttgacctgtttttgcacaaagagtccaattgtttggttatttagca/t/ FLJ37396/hypothetical protein FLJ37396 1914/2/rs11693731/58741154/[a/g]/tgaaaaggctctatatactgcaattgacttgtatcaacgaacatttt 10 taagactctcagg[a/g]ccaggcgcaatggcccaggcccatacagcactttgagaggcagaggcaggagaatcatgt/a /FLJ30838/hypothetical gene supported by AL832565 1915/2/rs7603997/24378462/[t/c]/tgtcagtaaggtgcattgcaagaataaactcttctgcttttagctgtc catcaccatcaa[c/t]gtcagccagagtcctaaagaaaatgttaaaattcacaacttaataaagtctatttggagt/c/ ITSN2/intersectin 2 1916/9/rs3802378/93578021/[t/c]/cctttcaggagcctttaatttgcttcttatgcaaagacaacagcattc tagcaaaactac[c/t]cagtatttgtagaaaacacagagggataagacattatggtaacctctagagggattttat/c/ ROR2/receptor tyrosine kinase-like orphan receptor 2 1917/20/rs3787158/56253830/[a/g]/atagaatgccctttctagttacgaacagccaagggtggcctcctttt ggagcctattaac[a/g]cagcccttagctaaactttaaggttcttgtctttgtacaggaaggaaaagcacaactact/g 20 /PPP4R1L/"protein phosphatase 4, regulatory subunit 1-like" 1918/21/rs2837286/40198160/[c/t]/ggtgcaagattatctttcaagacctacgtgctgacttaggcagattt tgcttaggatata[t/c]tttatctgtcaactctccttggtatgtggaattgtgtggagtaaggcttcgtgtgcaagg/t /PCP4/Purkinje cell protein 4 1919/13/rs1535581/42834468/[a/g]/aggtggcatacagacactaataagtaagacctttctaacagcagggg ctatgaaaatact[a/g]tactgagtagccacaaggg/a/ENOX1/ecto-NOX disulfide-thiol exchanger 1 1920/15/rs2129774/51640623/[t/c]/tattatttgattttgagtatcataaactgcattgttcagaacacctg gaatttttacctt[c/t]aataaatgagacaactggtgtagcacattcaaccaaaaggacttcatttgaaattaattc/c /WDR72/WD repeat domain 72/ 30 1921/2/rs838440/232280255/[c/a]/ctagctcacgtgggcgatccgagaacaacaggctacgctggccttatc gccaccgcactt[c/a]gctgtcgaactaagaaatcggttgtgtgggaaaaaggaccagaataggtggaaagatagt/a/ PTMA/"prothymosin, alpha"/ 1922/12/rs2729661/26053237/[t/c]/acccagatcttttgacttccagatcagtccagtgttttttcttgcac actggtagtcccc[c/t]gtgtaccacaaaatggatttctgtagcagcattcccaagtttcaagttatatgatgctta/c /RASSF8/Ras association (RalGDS/AF-6) domain family 8 1923/12/rs16919488/32261491/[a/g]/gacgcagacgtcctctaactcctacaccaatgcagtgatcattgac aggtccacaaccaa[g/a]tgggctcactagttgagcattttagtgatagaaatatgtaggatgaaaatattcttcaat/ g/BICD1/bicaudal D homolog 1 (Drosophila)/ 1924/12/rs12306165/47459419/[c/t]/tgtgagacttgaacccaggacaatcagattccaaatcctgtgtcct 40 aatcctactatcta[t/c]ctactgcattccatactttgtagtgcattccaggtttccaagattcctactcactctact/ t/ADCY6/adenylate cyclase 6/ 1925/12/rs11168740/47466900/[g/a]/gaagcatgatctttggcatgagaccagggttccaaaccttagcgtg attatttgctagcc[a/g]cactgccttgggcaagttatttaacctctctgtgtcagtaccttcatctgcaaaatggaa/ a/ADCY6/adenylate cyclase 6/ 1926/15/rs2289524/76177469/[g/a]/gccctgccaccctcaccctggggaagtggggcgcctacccgggggca ggcagcagtcagc[g/a]tctctttgaagggctcgagctgtgcctcctggtaatggtgcacaagctcagccagggtgc/a /hCG_38941/SH2 domain protein-like/ 1927/2/rs11889974/79791408/[g/a]/tatgtttgtgtgtgtgatgtgtgtctgtgtgttgtgtgtgcatatga gctgtctgtgaat[a/g]tacatattcctgcttagtgatataaacatcctctactttcagagaaaagtctaggtagac/a 50 (158) JP 2010-88432 A 2010.4.22 /CTNNA2/"catenin (cadherin-associated protein), alpha 2"/ 1928/5/rs6595959/97938006/[t/c]/ctctcctcattatcagcaatgtagtggtgcttttcatttcatggattt attgtttgtgac[c/t]gtttatgttatatgtgagcatcaggtaatgggtgacaggcaagattgcaaacctgaggag/c/ LOC642909/similar to C-terminal binding protein 2/ 1929/3/rs9831813/129961232/[a/g]/ttacaacaccccatggtacctgaacctcaagtaagctctgttaggtt ttcatatctgccc[g/a]tgtatgatggtgactttttttttttctgagacggagtttcgctcttgttacccaggctgg/g /RAB7A/RAB7A/ 1930/3/rs6780207/129935499/[t/c]/agcagtatataagaagtccaaatattccacatccttgctagcacttg taactttttctct[c/t]taattttagttccctctggtagaaagccatttctttatggcaccatggtacagcttgttt/c /RAB7A/RAB7A/ 10 1931/3/rs9310863/2852547/[g/t]/ggaatcctggaaatcaaaatcagtaccttaagtattcacctcatgcaat tcaaaggaaca[t/g]agcacaaacctaggggaaatggaaagaaagaagataaaactcaaaattagtgaattagaa/t/C NTN4/contactin 4/ 1932/15/rs2163195/52127362/[a/c]/tagtgttaattatatttcagttttttgcccattatttcatccctgaa tcttcagcctgaa[c/a]aaatatgaatgctgataataaaacattgaactatttaaaaatgtatgttattattaattt/c /UNC13C/unc-13 homolog C (C. elegans)/ 1933/9/rs3763630/35721004/[t/c]/gtacatcctgggtccctatttcccacctatgttgtctgtaaacaacac agtccagaatct[c/t]tgtcccctaactgtggtggccacagcaagggccttgggcttagagaatggaataaagaag/c/ TLN1/talin 1/ 1934/12/rs706527/26012887/[a/g]/ccatgcaaacaggagctttgtgtgttttactctctgctatatcctcat 20 tcatggaggggc[g/a]tgcagtttggctttgaatgaacaactaaaaggatgaacaaacaggctgggtgcggtggct/g/ RASSF8/Ras association (RalGDS/AF-6) domain family 8 1935/1/rs2768395/72174618/[g/a]/ggtttgctcttgtgtcttcctcgctagactaaaacttgtagacagcaa cagacaatacct[a/g]tttaaatccatagatatcttataaatgtttgctagctaaatgaatgctttataaaaaagt/g/ NEGR1/neuronal growth regulator 1/ 1936/3/rs883207/127215771/[t/g]/caggctgttctagaggatgcaaacaattgtcttcaggcagaggactgc tgcgatctattc[g/t]gcttggcccatacataattttaaaaagaaaaaggaaaaaaaaatctcaaattaattggta/g/ SLC41A3/"solute carrier family 41, member 3" 1937/3/rs3817079/127224282/[a/g]/gcagcttcttctacagacacaaaggtaaagagtgtcttcttctatag acacaaaggctcc[a/g]tggagggggggccctggagcaggtcaccactgaggctgagtgggtacttttgcacccagc/g 30 /SLC41A3/"solute carrier family 41, member 3" 1938/3/rs9840962/127234322/[c/t]/gatgtactggttctggaacccaggtgcgggataaagtaggtatcatt ctaatgtgatgga[c/t]gggggagtcagccctgttcaaggctatccagtggataaacaatgggctgatctgatctca/t /SLC41A3/"solute carrier family 41, member 3" 1939/3/rs4646760/127305561/[g/a]/tggggaagattcttaaatggctgcctcagattggctttgtattctgg ggagtcctggccc[a/g]ctatccactgccagggataacctgggtaagattcatgacctcgctgggcctcgacttctc/a /ALDH1L1/"aldehyde dehydrogenase 1 family, member L1" 1940/1/rs1316277/15412540/[a/g]/acctctcccccatacgttattcctgtgacaggaacttttgcaaaacag taaaatttacaa[a/g]atgtttagctgggcaaggacctgttttcaattctgcattttttccagtctctccgaaagg/g/ TMEM51/transmembrane protein 51 40 1941/4/rs2378799/179057539/[t/g]/gtgagaagatcaataaaggagggaaaacataatagagggtggtgttc ttccaaggctagg[g/t]gtccaatctcattagagaagctgcggctttagcttacttgatgacagtaacacacactga/t /LOC285501/hypothetical protein LOC285501 1942/20/rs2144944/16341851/[t/c]/acttaatttgtaattttgcaagcatttctaaacctccttgaaataat gacttctttgaga[t/c]taattcagagtttgctaaatacccaaagacagacaaattccagagagtcttcagagggga/t /KIF16B/kinesin family member 16B 1943/6/rs9459093/158344681/[c/t]/tcattatttttctgacctgtgggccgggcttcgttggcatttcctta aggcgtgttattg[t/c]ggaaaatattattcaagaaagaagagcatgtggtttgcttggttactgagctggactggc/t /SYNJ2/synaptojanin 2 1944/3/rs9825721/152160923/[g/a]/gtcagagtacatgtctctgcattgggaccaaggaatcctccatagta 50 (159) JP 2010-88432 A 2010.4.22 gtccttgaagtac[a/g]tggaattcaggcaaactttctatcttgcagctcagtcttttactttttttttcctgacca/a /CLRN1/clarin 1 1945/9/rs10513311/119648541/[a/c]/tttttaactaaaagtacaaatcatcctgtgaaagaccacaaataga tatttgcatttctg[a/c]agccagactagaagaccaaaatccatcaaaatccagaatgatggcaaatagtggtggaat/ c/LOC100129489/similar to hCG28178 1946/1/rs11211059/45202805/[t/c]/acttgcatttagctttttgaacatctgaaaatagtacatatgctcag tctttctaataag[c/t]tgtctccagcatggggatttcattggcatagtttgttctttgttgtaacatgttagctgt/c /EIF2B3/"eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa" 1947/9/rs7043114/94427804/[c/t]/cacaaagagctgcaactagagttttgagcatgaagcaactgggaaggc tgagctgtccta[c/t]agtccagtgccactatcagcactgattctaggaataagccacagggtagaggatctatct/t/ 10 IPPK/inositol 1 1948/19/rs1725474/43276212/[t/c]/aatgctcatatcccatctgctgggagatgcaggtccactcgagactg tctgcttggcggc[c/t]ggggacggccatctggggcaggctggctggcttggaaggcagcccagacctctcgctctg/c /SIPA1L3/signal-induced proliferation-associated 1 like 3 1949/1/rs6425820/33708934/[t/c]/cctctctctgcacactcgcctcccttcttcctcttagggcagatgatg ctgaagtggaca[c/t]gtccttacctgaccctgcaaagctgcctctccagcttcagatcctgacactctctcaaat/c/ ZSCAN20/zinc finger and SCAN domain containing 20 1950/4/rs5343/148684442/[t/c]/atcatgtcagtgaaaaataattacccacaaatgccaccagaacttaacga ttcttcactt[c/t]ttggggttttcagtatgaacctaactccccaccccaacatctccctcccacattgtcacc/c/ED NRA/endothelin receptor type A 20 1951/6/rs4441926/77337162/[a/g]/ttcattcagtcaataaatatttatggagagcaaaccaggagaaaaata gttgtagtatga[g/a]gagagagaagtaattagattcaaatgatactcaactagaacttaaagattaataaaatgt/g/ LOC643281/hypothetical LOC643281 1952/5/rs465454/112258230/[g/a]/ttaggatgttagatgctaaaaacacttgctgctctccaaatagttaat atagtaagtaac[a/g]attgctctgtgtgcaggaatacatagcacatcccctgtgatgctctgcatattcttcaaa/a/ REEP5/receptor accessory protein 5 1953/9/rs567900/102864509/[g/a]/aataataattgtgcaaatggggctcattgattgcctggattttagttt agccctcattag[g/a]ctacatacaggctaatattcctttaatattggtagacctgagttttgcagaataagcaaa/a/ RP11-35N6.1/plasticity related gene 3 1954/9/rs2418206/114184402/[c/t]/cgagagagagtgagagtctgtctcaaaaagaaaaaagaggaaatgca 30 ctttatattttga[c/t]agatatttccagatgaccccccagaagggttgcacacccaaaaggataaatgagatcctc/t /HSDL2/hydroxysteroid dehydrogenase like 2 1955/10/rs10510056/121031723/[c/t]/cactgacttcacttgctcctccccccactcacattttggggccct aaattactttagtat[c/t]gtgagtgagcactgggctgtctctttcacagtctagatttgcacaaacctttctctgagc /t/GRK5/G protein-coupled receptor kinase 5 1956/14/rs366476/88004404/[c/t]/tccatctcccaaccaggtttctgccaggacactcgtgtcctcccatcc tttctgtctccc[c/t]aggggaacacattatcttcattaccgtttctctcaacctaggtgctggacatcccgagag/t/ PTPN21/"protein tyrosine phosphatase, non-receptor type 21" 1957/8/rs556388/103175730/[g/a]/agtacagtatctaccttacagagctattgggaggttcacgtaagacga tttatacaaagc[g/a]tctggtacagtgcctggtacagactaagtgctcatttaatgctatttcctacttcccttt/a/ 40 NCALD/neurocalcin delta 1958/6/rs9388724/130041921/[c/t]/gtttttaaaagttgaagtccagtgccttacttacattattctgaata tcaattgtctcta[c/t]agaatactgtaggcataggatccatttgggttttatctctactgaccctaaaaacacact/t /ARHGAP18/Rho GTPase activating protein 18 1959/8/rs7830520/143317377/[t/c]/ggaagcacatccgcttcacctaatgctgtgactgtcaggcatcctgg tgactgcgttacc[c/t]gccccccctccaccctgcacccctgttggcctctttctggggagaaggagtgccgtctgt/c /TSNARE1/t-SNARE domain containing 1 1960/19/rs1558357/61486457/[a/g]/cacacacgtacacacccttatgtatgaatccaatactattatcatca ttattattattac[g/a]tacttcatattactatttctaactttactaaatgttaccttgagccaggagctaggctaa/a /LOC729994/hypothetical protein LOC729994 50 (160) JP 2010-88432 A 2010.4.22 1961/3/rs2697144/11026099/[g/a]/tggcctgaaccttatggactcccaactcccagccagccgcatactctt actcaagagatg[a/g]aggaaagcagtttcatgccttggtataaacccctcagctgcctcaacgtacctgagaggg/g/ SLC6A1/"solute carrier family 6 (neurotransmitter transporter, GABA), member 1" 1962/22/rs6518660/15955800/[g/a]/aattctcattctctttaatatttgcataatattccatagtagatagc aatctattcaacc[a/g]tttctagtttgatggacatttagatttaaactagatctcaccttaattcagccattctct/a /IL17RA/interleukin 17 receptor A 1963/4/rs668055/138168349/[a/c]/aggtccaagataaagtttagttaaatgtggttctacaagactcggaag aatagaaacaga[c/a]gcattagagacaaattaacctatagccataataatggccttcattttgtaagttatttga/a/ LOC729578/hypothetical protein LOC729578 1964/8/rs12545907/40545260/[g/a]/ggcattttcataattttgggatagaagtattgagggttacacctcaa 10 cattcatctaccc[a/g]ttcctcggggcccatttagtacttattattattattgttgttgcttttgttcttaaaact/g /ZMAT4/"zinc finger, matrin type 4" 1965/12/rs2216225/15234137/[c/t]/aacattgtaaactactacctagaaatggatagagaattatgaaaata gcatatttgggaa[t/c]gtgtagagtttaagaaatcatgcaggtttcttaacgtcaagctccctggtttgtaacctt/c /RERG/"RAS-like, estrogen-regulated, growth inhibitor" 1966/18/rs1941136/7584890/[c/t]/aaactcagtcccgagaagtgggctttgaggatgatcatttaaaagaag ctattttttacc[c/t]tgtgaggtaggctgatttgtttctaaatcaaatcagttatacatcatctttgcctcccat/c/ PTPRM/"protein tyrosine phosphatase, receptor type, M" 1967/2/rs10194776/231688263/[c/t]/attttcaagcatcaagtaggagatttttttaaagtcaggtaggatt tcagtgaaaaatat[c/t]tgggcacttgacaaagtatccagaaggtagcaaggctgacacatctactttttggtgcct/ 20 c/HTR2B/5-hydroxytryptamine (serotonin) receptor 2B 1968/3/rs7372541/54517973/[g/a]/agggaagacctgtaaccaccactgcagagcatgagaaatcagtctgtc tgttacagtcca[a/g]taggttcttctaaaaagcccaagaaaagggcagaagtctgatgagatggcattgggtccc/g/ CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 1969/8/rs1362911/30984486/[a/c]/taaagtgtgatcaacctttaaaaagctatttttttcagagtcaaatga cccgctaacata[a/c]tcttataataatgttttcaacttgaaaataaagaggtgagaaaactcttcgagttgaagg/c/ PURG/purine-rich element binding protein G/ 1970/8/rs4733687/130321411/[g/t]/tttaccagtgacaggtactttaaatgagctcatttaatgtttaagat ggtcctgaaagtt[g/t]gatattaatataatcacctttaagaaatgattcagaaaagttgagtaattaacctaatta/g /hCG_1814486/hCG1814486/ 30 1971/9/rs7858642/129895939/[t/c]/gtgatcactggctgattggggctggcctcaccaaatcacaaaaagga cctccagaatgtt[c/t]tggaaacatttttgaaaagttcactttaggccaggcgcagtggctcatgcctgtaatccc/t /SLC25A25/"solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25"/ 1972/5/rs2973741/177754271/[a/g]/aatcatccttagctagcatttggctgcaagttcagcctcctggttcc tgagtccaccctg[g/a]cacgcagaggggactgctgatggtctgactcccatctgctacacatggggaaactgaggc/g /COL23A1/"collagen, type XXIII, alpha 1"/ 1973/10/rs928670/121021649/[c/t]/cccgttcagcagagatggttccaaatgttctgaacttctgccttgta tgggaccctgtgc[c/t]ggctgaatcgcatggtagctcagggcatagatgctaaatgggacggtcctgggtttgcac/t /GRK5/G protein-coupled receptor kinase 5/ 40 1974/11/rs1212146/64169453/[g/a]/ggggagatatagagggtaaaaaagaagggaaagacagaggtatgtaa gagatcaatagag[a/g]ctgcagagatgaacggagacagggaggcagagatggtaaggaattgaccgcctgggagag/g /NRXN2/neurexin 2/ 1975/19/rs1078000/17482508/[a/g]/actgattttaaaatccactacctgtgtgagttgaactgcgcttacac acatcactgaaat[a/g]tcccactctcagaagtggcccagcctccccaggcccaccaggccttcttccccttccagc/g /PGLS/6-phosphogluconolactonase/ 1976/5/rs1061837/150541530/[t/c]/aaagccctggagggaatcacatgtgtactttttcatgaagctttttg caaagcacatctg[t/c]gatacactagtttattgaactaatgtccaggagtagacatgattggtggccaagttattt/t /CCDC69/coiled-coil domain containing 69/ 1977/2/rs6757782/152986745/[c/a]/ttaggtattttacgtttattatctccaatcctaagtaatgccttcaa 50 (161) JP 2010-88432 A 2010.4.22 gctaggtaggttt[a/c]ttgatgaggaaaccggtgtggataggtcaaaataaactgttttaggccatgcaggctgaa/a /FMNL2/formin-like 2/ 1978/9/rs2575875/106702315/[a/g]/gttgctctggggtataccattcagctccaggctgaacatagcgtttc tagtcttcctggc[a/g]gcagcacacaggctttatgtatgctttctattcttcctagtgcaagggagcctcctcaag/g /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 1979/11/rs662798/131891565/[c/t]/aacacaaatgacttacattttgcaggcgatccaaaagtgactattga atgggtacacaca[c/t]atgtatccatcgtatatcgatcctgtagcgtgccagagaaaaaaaaggggaagacagtgg/t /OPCML/opioid binding protein/cell adhesion molecule-like 1980/4/rs899694/5803954/[t/g]/tcggcagtggtggtgcaatcgatgtgcttatattggagggaggatggaag tggagagagt[g/t]gcgtgagaagagggatgtggaatgggggaagggggccctgatgtgctctgagtgtggctg/g/EV 10 C/Ellis van Creveld syndrome/ 1981/4/rs2375801/187708619/[g/a]/atctccacagagtctttggagctcattctgcccattcttccttagca ccttttaaaaata[a/g]tcaacagaataactgaaatgaatggtaagatctttacaaggtgccttaagctttcccttt/g /MTNR1A/melatonin receptor 1A/ 1982/1/rs1737352/14993113/[c/t]/caggagaggagagctgaggctcaaggtgagattttagcaaacgctgct tatgtaactgct[c/t]gtgaacaaaaggtcaggacctgtggtgttacttttgattaccctgaaataaccaatctgg/t/ RP1-21O18.1/kazrin/ 1983/2/rs7600752/144894580/[g/a]/caccctcatttttcagctgaagaaacctcttgtcttcatgaaattga ctacatgaaataa[a/g]ggcaaacaatataaggaggaacgatgaaacatgctgaagttagccacatacaccttaggg/a /ZEB2/zinc finger E-box binding homeobox 2/ 20 1984/7/rs11974409/72627326/[g/a]/ggccagtggagtgtggatccttggccagacatccctatgtagggagt aatgtgcacaacc[a/g]tctctagcggccctgctttgggtaagttagtgaattgctctggaccttggtttttttttt/g /TBL2/transducin (beta)-like 2 1985/7/rs2286276/72625290/[a/g]/tggcctgggaggagacatgtatacttcgggcagcagaggccttgtaag tgtctttggaga[a/g]tgacagttggtcaggtcactgcccgtgacccacatcactcccttcccgctcagggaagtt/a/ TBL2/transducin (beta)-like 2 1986/3/rs1720819/139583229/[c/a]/gtcccagcttctgatggtgcaggagaagagccaggcttttgctcttt gaaaacactgggc[a/c]cttgctggggagtcggagacagagaggttgcggagctgggcccaagaaccccaaggtagg/c /MRAS/muscle RAS oncogene homolog 1987/3/rs6442737/2542333/[t/c]/aaaaatacagtattttacatttctgcagaatcttgtcactacagttttc 30 tttcatttgaa[c/t]ttaacagatgccaagattttccatttagtaagtattattactagcaaatatattatctgg/c/C NTN4/contactin 4 1988/2/rs998429/115364053/[c/a]/gaaaggagacatgacttattcatctgcatatccatacctaaaatcaga gcaactgctaca[a/c]atttcgacacagtagtaagcatttgtggaattgtatctagtcttctccagtgggctgtgg/a/ DPP10/dipeptidyl-peptidase 10 1989/2/rs11693860/24223178/[c/t]/gtaggttaccatcccaccatttcatgaccctttgaaaaaagcacaat atgacaaggataa[c/t]gaaaaaagaactcttcttcagtgtgagactggtacttagttcctaattgttatgtgattt/t /LOC375190/hypothetical LOC375190 1990/6/rs647942/48134336/[c/t]/attctaaatagagctagccttgaccactttcttccctcttggttttgtg agattatggtt[c/t]ttctatttctctgatggttctctaccgtttgctggcttactttcttttccattcccataa/t/C 40 6orf138/chromosome 6 open reading frame 138 1991/2/rs11695685/79776310/[t/c]/atgaagcagaggacatgaacattcttactgtgtgttctccatagact ggccaggtccact[c/t]catggtctcttatcaggcaaaaaaggaggggcagcatgctggtttcgttttagcccttag/c /CTNNA2/"catenin (cadherin-associated protein), alpha 2" 1992/4/rs3822095/90955540/[c/t]/acaatccataatgtaactgaattcattcctatgaactgaattccaatt agatttatcata[t/c]tgttgttgtgaacaccagagaaaagtaggacagtcccacatctaagcaggaagataaaat/t/ SNCA/"synuclein, alpha (non A4 component of amyloid precursor)" 1993/12/rs3217881/4272949/[g/a]/gatatatcgtgtgatgctgaggtttgggcttcagtcgaacccgtcacc cagacagtgtac[a/g]cagtacccaatagggagtgtttcaactctcgtccctgtccctagacacattcttaaatat/a/ CCND2/cyclin D2 50 (162) JP 2010-88432 A 2010.4.22 1994/5/rs712665/112255698/[c/t]/ctcgatccttctccattactctgaaatccacgggtggttctgggtttt gccatgtggtac[c/t]attttctaaatcattttcagcctgatccagcatcttctgcacagcttcctctttttcttt/t/ REEP5/receptor accessory protein 5 1995/13/rs2783224/99890202/[t/c]/atagaatgcagtggtgctacaatcagctctgcactgttatttataat aaatttatcttct[c/t]ttgaaaatatttgagcaagaatatgagaaatagaaagaaaaaagtcttcaaaggtacagc/c /PCCA/"propionyl Coenzyme A carboxylase, alpha polypeptide" 1996/12/rs2466453/116760315/[g/t]/tcaaaaacccaacccaaaacgttatgcatggtccattgtgctgact tttggggtctgttc[g/t]gcatcagactgagttctttggggagtggggaccacatctcgttgtctttggagtgctgta/ g/KSR2/kinase suppressor of ras 2 1997/9/rs3750434/35729876/[a/g]/gaaatggtttaaggaacatgtacctcccaagatggaaaggatttgggg 10 gttcagcagagt[g/a]ggatcatcaaatgaatcccagtgcaagtctactgactttggtgggtggagagtaaatcga/a/ GBA2/"glucosidase, beta (bile acid) 2" 1998/14/rs1998053/100389787/[a/g]/ttgttccatgaatcttcataacctcacttgctgcgttgtgccttgt tgagtggctatggc[a/g]tcattcacagaaccattctgttattcttatgtataaccaccttttaaaaatattatgaat/ g/MEG3/maternally expressed 3 1999/1/rs3010380/115990494/[g/a]/caatgagcctggccgtgtcctaatatttgcctccagcccctacccaa gcagtgccaagca[a/g]tacactcttaaggggtgggtgaccggtgaggcaagatgctcttgggcagtggctgaaaga/a /VANGL1/"vang-like 1 (van gogh, Drosophila)" 2000/1/rs12139143/45122615/[a/c]/aggggtgaaagtatgggcagctctataaacctgacttgctgcatact tcccaccacctct[c/a]ccagcccccattcaaagctctgcatgctgacacaaaaccaaacagatggagtgtaggtag/c 20 /EIF2B3/"eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa" 2001/15/rs3098183/48593761/[c/t]/aatctataaatctgtcctgccagaagtcagtggttttccagactcga aggcaggtacaag[c/t]acagttagggtgctggtaacattctgtttaaactctgttctgctggttacatgggtatgt/c /USP50/ubiquitin specific peptidase 50 2002/14/rs4903329/75113654/[g/a]/attcaatttgtttagcactgtacaacaaatgttagctttttgctagg atagccagcattc[g/a]cggaatgcttactatgtggcaggaattttctaagtgcattcgtgtattaattcattcaag/g /FLVCR2/feline leukemia virus subgroup C cellular receptor family 2003/3/rs3903470/24483025/[g/a]/tgcagtatctccaaagtgtgcctgtagttgagattggagggtactcta aacaagaattag[g/a]taaatgtgtgcatactgaacacggagccagcagaactcttccccactgggtttccggaac/g/ THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on 30 cogene homolog 2, avian)" 2004/2/rs4148189/43901034/[a/g]/ctaggcagaacatggttatttatgaagatgcctgtagagttcaacaag cctgcttactgc[a/g]gttagttgtgaccattgtctaagtaatttaatgttttcctatgagagctgaaggagccgt/g/ ABCG5/"ATP-binding cassette, sub-family G (WHITE), member 5" 2005/7/rs4073362/101310585/[a/c]/attctcaaaaaggttaaagtacactaccagcttcaacctgaatcagg ttcatcatttctg[a/c]cttttaaaatgctccctttacatcaatatttcattgagggaatcattgtcctttcctagg/c /CUX1/cut-like homeobox 1 2006/7/rs10276437/47772602/[c/t]/gacactttcatttgtgctaagctgataagtatcaaacgatgatgcag gctattcattatg[t/c]gtgtccttgattactgatgagtttgagcaattgtcatttgttggactgatcgttcaattt/t /MGC16075/hypothetical protein MGC16075 40 2007/8/rs17632167/17371563/[a/g]/tttgtagaaacataaagcttccaggctggctctcatatagcctgtgc tttggggaacaga[g/a]acacattgtccacatgaaggccaagaagaatctgatatccagatacctttctgtgttcag/g /LOC646479/similar to ADAM 29 precursor (A disintegrin and metalloproteinase dom ain 29) 2008/3/rs7613553/25452416/[a/c]/aattatatatacattatattacagtagtcgtgccatggagctactaaa ataccgttgttg[a/c]cattttattacaaaaaaaatcacgattaatgcctagaaattgaaagctgaaaaatgtagc/c/ RARB/"retinoic acid receptor, beta" 2009/2/rs872943/206335718/[c/t]/actgagatttcctcaccaaatgccaccttgttctctgtacaagtggcc agaatggtcctg[c/t]acaagttggatttgaaggtgcaggtcacacctgtgttctgcaaggcacgtagtctgccaa/t/ NRP2/neuropilin 2 50 (163) JP 2010-88432 A 2010.4.22 2010/1/rs3767132/21879308/[a/g]/ttccttagaaaatcacaacctgccaggggcttctggagtggccagcaa agaatcaagaca[g/a]caacaggaaaatccgaaaacgtcagaggtctgtatttgatgacttcttgaatattatcgg/g/ USP48/ubiquitin specific peptidase 48 2011/9/rs10759021/8931696/[g/a]/taaaaatattatatttcacaaagttaaaacaactttgagagaaagctg tcagtgagttaa[a/g]gtggctgaaacagatctcacaaaaatccagcaaaaatacgactttcatcaagggctttta/g/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 2012/1/rs3006475/151611260/[c/a]/tcagagatgaacatttaagccaaggacttcttctttcatctctgtat ccctagcatccag[a/c]ccagtgtcttaggggaaaacttttggagtaatccttgatttttcaatttccaccttcaaa/c /S100A12/S100 calcium binding protein A12 2013/13/rs1359186/42363831/[t/c]/actggaacttaccacacacacaaggaaacaagtggttgtgattcaac 10 atcacaaacacaa[c/t]agaaagacttagagccagatgatttcacatgctaaaatgattagatactgaatttaaaat/c /EPSTI1/epithelial stromal interaction 1 (breast) 2014/18/rs10502622/29538006/[c/t]/ctactaatatgtcactttttggaaaagagcagtttatttaacaaat gcctttggcatact[t/c]ggaaatctagcacaggaaaacaaattgaaaccaaaatttattaccatataaaaaagttac/ t/ASXL3/additional sex combs like 3 (Drosophila) 2015/17/rs1808693/62917942/[t/c]/cctccaaccctggacagcagggaagcagcagtgccctgcacccagat gacccagaaagca[c/t]ttcttaatgaacggcccggcattgtgactcatgctggctcccacatctggcagatctggg/c /PITPNC1/"phosphatidylinositol transfer protein, cytoplasmic 1" 2016/13/rs7330977/101535664/[g/t]/ggggaggaaggaagagctgagctacaaaattaatcagctccaggta tgtgccaggcattg[g/t]acttaatccaagttcattgaatctgaaaacaatcctaaaatgaagattccctcaccccaa/ 20 g/FGF14/fibroblast growth factor 14 2017/6/rs4896886/147095325/[t/c]/tggatgaaagagagcccaggtggttggttcaccatttcatgctacca agattactcctca[c/t]gggctcaatgtagctggccctgatttaatatgtaaggggtcttggtgaatgaatcactta/c /C6orf103/chromosome 6 open reading frame 103 2018/3/rs9819530/122870474/[g/t]/ttttgttctcagatccaaagtttcctacaattttcttataacttaaa gcaaaatcaacac[t/g]ttctctgtttcagagtaccaaatgtctcagtcatcactgtttcctactcatgttttgatt/t /GOLGB1/golgin B1 2019/13/rs9576827/38978381/[a/g]/ttcagctctggcttctgtggacgtaatattctgtgatcaacagtgcg gttaatagatgtg[a/g]ttaggaaaacaagaagaggctaccataaaaatgtatgtgaaagagcacctgagggtcccg/g /LHFP/lipoma HMGIC fusion partner 30 2020/4/rs10017409/75381542/[a/g]/atgctggacctgagaaggaagaataaatattcatcagctggagaagt gagagaagggcac[g/a]ttagacaaagagaatagtatgtacaaaggcaaatcttacatccaaaatgactgtttttaa/g /MTHFD2L/methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2021/5/rs1864182/81584996/[g/t]/gagacattgatctttgtaacggcaaaacattaaatccaggcttttctt ttaccttgttaa[t/g]ggacatttcgttcatcctgagacgttgctttggcataactcagaggtagattcagcccaa/t/ ATG10/ATG10 autophagy related 10 homolog (S. cerevisiae) 2022/8/rs10095917/56992814/[t/c]/ctccactcacatggagacagggccctgccttttaggcacttactctt ccagtgtctattg[c/t]ataatatgttcaggaaggatcccagattcaaagatttatagaattagagttaaaagggat/c /LYN/v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 2023/14/rs7144864/94775357/[c/a]/ctgaacacatcactcacacacccagttagcagacattgatgactata 40 ctcaggcataaat[a/c]ctaagacatagacctcatgggcttcctttggcaggtttgagaagaaggaatgaacgcagg/a /CLMN/"calmin (calponin-like, transmembrane)" 2024/2/rs713397/201065869/[c/a]/catgtgtaacatgttcttattgagagagtgattctaaaattactagtg gacacagtgggc[a/c]tgctgtggtaaatatttttgctccacagaagtggaatcccaggctttactggcaatagta/a/ KCTD18/potassium channel tetramerisation domain containing 18 2025/1/rs1949133/68015985/[a/g]/aggtttggaaaaaacactaccatttatagttacgctggcctcagactt tgaacactcccc[a/g]aagtagatgagagcatgctctctctattcaggaagttaaactgtgttggcaaaaaatgtt/g/ GNG12/"guanine nucleotide binding protein (G protein), gamma 12" 2026/2/rs12470143/31617062/[t/c]/gagtttaatctctcattaaacctctcccgggtatttgtaaaagcctc ctcatttgaccac[c/t]acatttactccaccgcaatctattctccatatagcagaccaataaagctgtaaactggat/t 50 (164) JP 2010-88432 A 2010.4.22 /SRD5A2/"steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid d elta 4-dehydrogenase alpha 2)" 2027/1/rs11161862/86872826/[g/t]/gtattttcaactcatggtgcctaggtatacacattcattgagtgata actttccaaaatt[t/g]cttcaacagtatttaccatttatatagcatttatctaaactgtcagattaatacctgctg/t /CLCA3/"chloride channel, calcium activated, family member 3" 2028/20/rs6115830/325226/[t/c]/gctcacagccacaggcatcctcctgcacccctggctgcgacaggacccg atgcccttagc[c/t]ccaacccgatcccatctctgggaggctgcccaggtggtccctgatggactggggctggac/c/T RIB3/tribbles homolog 3 (Drosophila) 2029/1/rs7513/200205618/[a/g]/ccagctttttattgtttgaataacagaacacacaaaaccaggcagagaag tccgcaagga[a/g]atgatgatcatatttcactgttttttggccttttggtccttcatctttcaagcacttact/g/TI 10 MM17A/translocase of inner mitochondrial membrane 17 homolog A (yeast) 2030/3/rs6445190/61045494/[c/t]/gagttttgaatacatttatatagttatacaaccatcacctctacatag ttttagaacact[t/c]ctatcaatccaaactgttacctcatgccctttgcagttaatccccactccccacaccagg/c/ FHIT/fragile histidine triad gene 2031/4/rs10517281/53722352/[g/a]/ttcttactacagattagcatttatccaaagtaagagcaggaaaacat aagaagcttacag[a/g]attcatcaaataatctaattcagctacaagtacctttggctaggaagatagggaaaagcc/g /SCFD2/sec1 family domain containing 2 2032/7/rs2903582/70687592/[a/g]/atttctcaaaactcagttatattttctcaaaaaaatttgtttgatagt cagcttactcaa[a/g]taagaatcccagcaaggtctacacactgcatttggctgatgtgtctctaaagtatctttc/a/ WBSCR17/Williams-Beuren syndrome chromosome region 17/ 20 2033/17/rs7209469/58568431/[g/a]/ctgctttggagggccaggaaccagctacttggcctgactgttaaaag taaggcataaaga[a/g]gatgttgatttcttttgtgttgtatacttcaaatatccctcaatgtgaaagagccaatac/g /TANC2/"tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2"/ 2034/15/rs2445761/49402908/[t/c]/ggaaaaaatcaactaagcttccgaagaaagtaaagtaaatagtagaa cttgtgggatcaa[c/t]gataaacggagatggaactgttttatggcatgaaaaccttccagcacaaaatttttggat/c /CYP19A1/"cytochrome P450, family 19, subfamily A, polypeptide 1"/ 2035/2/rs6731881/229985242/[g/a]/tttgtctgaagacgggttacacagaggtcctccatgaattttgcttt ctaacaattccat[a/g]atctacagtgaagacttacattccatgaaaatgtttaagttggtttcctttacttaattc/a /DNER/delta/notch-like EGF repeat containing 2036/17/rs2240568/12823738/[a/g]/gcctgagcacctctaccgtatcctgccatcaacccaggaattctaga 30 acattctcaaact[g/a]gaacaccaaagtgcttttcctactgtagccaagaggacttctcagggccactgtgcccaa/g /RICH2/Rho-type GTPase-activating protein RICH2/ 2037/4/rs10007052/142225023/[c/a]/taaagagttttaccctttttaaaagaggaaatctgcagagaaaata gattaattcaaaac[a/c]aaggtaaatactagggatacaatatttcaaaaataatgtcaataactattttaactctaa/ a/RNF150/ring finger protein 150/ 2038/1/rs7531293/33720054/[c/t]/caccatcttgttgaatccccctctctgtcagatgccccctctccatca ggtgcacaggga[t/c]ttttaaaaaacaggctttattttttagagcaattttaggctcaaactcacagcaaaattg/t/ ZSCAN20/zinc finger and SCAN domain containing 20/ 2039/3/rs9289559/139573879/[a/g]/atgattcccgcatgactttgtgtataatacagggcaagaagcagaga gaaaggagccaca[a/g]tcatagaattctgaaacttggaaggggcctcagagtcccagagctcaggtgtgctaagct/a 40 /MRAS/muscle RAS oncogene homolog/ 2040/17/rs4889863/76165063/[g/a]/ccacctactttgactgaaagacttcagaattcttttctcatgacggt ctactgatgccac[g/a]ttcacttcgttagtctgaaaatatcttttttgtttgtgtgtttttgtttttttgagacag/a /KIAA1303/raptor/ 2041/1/rs10920285/200204037/[t/c]/ctcctgacctcgtgatccgcccgccttgacctcccaaagtgctggg aatgtgagccatcg[c/t]gcccagcaaaaaagtttttaaaacagtgaaaaaaggttagacagaactgtatgtaaatgg/ c/TIMM17A/translocase of inner mitochondrial membrane 17 homolog A (yeast)/ 2042/5/rs2973719/177733880/[c/t]/taacctgagccaatctttgctcctcccagcctctgcacacccttccc tctgcaacccttc[c/t]atccctgaggtgcccttccctccacctctctccactgcacaaactcttcctctcccttcc/t /COL23A1/"collagen, type XXIII, alpha 1"/ 50 (165) JP 2010-88432 A 2010.4.22 2043/12/rs885389/130187715/[g/a]/tgtgtgccctggggcctgctgctgagcagctcttctctccccgccta gttgctaagcgat[a/g]tgcaagcatcctctctccctggagaagtggcgactgcatcttagggagagtgagatgtag/a /GPR133/G protein-coupled receptor 133/ 2044/1/rs2789352/235070620/[t/g]/agtaagtaaaacatactggaatgcaatgcaaccagaaaacatggagt tttaatccactaa[g/t]atgggaaaatgccaacattatgttgagcaggggaaaagagttacagaataccaggtataa/g /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase/ 2045/1/rs3820571/235127056/[g/t]/tttgaagtccaaatattttgctgtggggaagatttccaaggatcagg taagctagctgtt[g/t]cattatatgtggcttgcctagttcaaatgaaattctagaacctctctcattttaaatgtg/t /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase/ 2046/2/rs3738861/124788821/[t/c]/catttcaaaagccacctatgtatgtatttatccaactatcagttcat 10 ctattcatccatc[c/t]atccactcctgcatatcctactttacgaatgtatttgacagcttattttatattatgagc/c /CNTNAP5/contactin associated protein-like 5/ 2047/13/rs1379518/59162465/[t/c]/ttaccttttcttcagcatgagcaggcaagaattaccaagttggctgg acagatgcagaaa[c/t]tcaggcatagtaaagttaaacaatttataaagcaaattagtgaaagagcttggcctatgt/c /DIAPH3/diaphanous homolog 3 (Drosophila)/ 2048/2/rs17040825/50638682/[g/a]/agcaggctagctaacctaggagttgtattttcacccatgaaagggtt tctgtggtatcta[a/g]caacagcggctaccactatcaccaaagccaccacaacaatcagttaagatttaccagttc/g /NRXN1/neurexin 1/ 2049/12/rs4768942/49641968/[c/t]/cgtggtaataatcttattactgtgagctgtaatgtgctccaaataca ggaagccttacta[c/t]aaagttacagtcctcattttcatcattcagcaaacattgattgaatgcctgctatgtacc/c 20 /HIGD1C/"HIG1 domain family, member 1C"/ 2050/7/rs11767065/94678852/[g/a]/ctgctcaataggcagcactcaagcccatttatatcactggccaatac tccccttgatgaa[a/g]catgttatatttttactaactctgggtctattacgactgacttgttgggtctgtcactcc/g /PPP1R9A/"protein phosphatase 1, regulatory (inhibitor) subunit 9A"/ 2051/10/rs9299597/28482847/[g/a]/tctattatgagtacaaaaaagtactgaaaattactgcccagtagttt gactcttcagcat[a/g]ttaattaatggtaccagatctagaattagcacatgcatgcatacacctatctacctccat/g /MPP7/"membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)"/ 2052/11/rs16924357/7262671/[c/a]/gttagtcttctatgtttacttgctcctttattgctttatctctcttt gcttcatattctt[a/c]gtgtcttcaaagacaaaagtttacctcagagtactttagtatgggtgaaccttttgctcc/a /SYT9/synaptotagmin IX/ 30 2053/9/rs3916184/87543051/[t/c]/gaaagcatttagagttttaatattagatccctgcaaaccaagaacaag tatgtaaaatca[t/c]actggagggaaaaaaaaagttcctaggaaaattatatgaaagctgaaaatgaacacaatg/c/ AGTPBP1/ATP/GTP binding protein 1 2054/9/rs10868343/87541520/[g/a]/caaaactatttgtataatactaaaatttaaaatcttaaaattactgg catcttggactga[g/a]ttaaagtcaccatcaaccaccaacaattataaaacaagaaaaagccagccatggctcacg/a /AGTPBP1/ATP/GTP binding protein 1 2055/7/rs4729761/101343779/[t/g]/ccaccctgctaggcttccatgcagtgggggaagtagggacccccggc caaaagcagtcat[g/t]ttctttttgtttttctcctaagttttctgcgtctgtgtgcgattggaacgaaacatcaac/g /CUX1/cut-like homeobox 1/ 2056/6/rs2753196/48101159/[c/a]/tataaaaatttggtccattgttcttaaaaacattgcctgtcattctcc 40 cttattgcaaca[c/a]agattaatttcctataattttgcaagtagtcagagaattcaaggtgactatgtcacccca/a/ C6orf138/chromosome 6 open reading frame 138/ 2057/6/rs4502986/4707143/[c/t]/ctaaataagtgtgattgagcttcctgctaaggacaactaagaaagctgg gggaaaagcat[t/c]ttaagaatctgattcaaagcagtagagaactaataagatgtttaaaaacactgagctagg/t/C DYL/"chromodomain protein, Y-like"/ 2058/4/rs7694402/110729529/[a/g]/aattggatataaagaatgattgataaaaaggaagtgtaatagaattt ttcatacaacctg[g/a]taaaccatttttgaaattcattggtaaaaggatagaacagtctagaaaattctgaaaaaa/g /CCDC109B/coiled-coil domain containing 109B/ 2059/1/rs12060264/235054986/[a/g]/cccccaagcggctatgtaacaagaatgaatgaatttcccttatggg aaggggtggggttg[g/a]gggtattctgttctgcctaacagtgaatattttctttcaaacggaaaagaaataatggag/ 50 (166) JP 2010-88432 A 2010.4.22 a/MTR/5-methyltetrahydrofolate-homocysteine methyltransferase/ 2060/18/rs4625812/17525302/[a/g]/attaatagaattaaatggagaaacacaaaatctacaactatatttta aaatgcttctatc[g/a]ataaaagataaaagtgagctatagtctgaaaaacattatcaatagtaaccaaatttaaat/a /ABHD3/abhydrolase domain containing 3/ 2061/9/rs7044405/35860001/[t/c]/aggcagaggacccaggcagctcccatcagcagcacgcagagccggtgg ctcatgagcacg[c/t]ggtacctgagtggctggcagatggccaggtagcggtcataggccgtgatggccagtagca/t/ OR13J1/"olfactory receptor, family 13, subfamily J, member 1"/ 2062/1/rs2290501/22047013/[c/a]/tcatcgtcaccatccagggcagcggttcctcccacggtgagagcagag agggcagggggt[a/c]cagacaagtggcgcagagggtggcagagaggtccccggtgccatcactgttatctcactc/c/ HSPG2/heparan sulfate proteoglycan 2/ 10 2063/1/rs3006488/151629131/[g/a]/gttttccaaccctccctccacaccgaggaacctcattccacaaaagc ataagagagaggc[a/g]tgaggtattgatgactttattattctgcaggtacatgtccaggggcccagcctctgggcc/g /S100A8/S100 calcium binding protein A8/ 2064/1/rs7554975/48214634/[a/c]/aatgacatttcctccactatctccccaaccccttcctttgcttgtttt cattcagcattt[a/c]tctctctctgacttcttattaatcatttgtgtactttgcatacttgtttcttatctgtca/c/ LOC388630/similar to C05G5.5 2065/19/rs10500204/7133963/[c/a]/ttgggaatacactggccaaaaaaaaaaaaaaaaacctaaaacaaaag tctgtctggtatg[a/c]aaaggtgatttatagacccttttggtcaataaagccaaaaggtttttttggtaggttttt/a /INSR/insulin receptor 2066/2/rs728005/178959252/[c/t]/aaaagatgacagatcatttcttggtcatcaccaagaatcaggcatctt 20 gtggagatggca[c/t]gaagttcccatagttcatcaaaatggaaccaggtggttatcacaaatgcacaaataaatc/t/ OSBPL6/oxysterol binding protein-like 6 2067/5/rs6580191/140945712/[a/g]/attcaaatagtgactaggatattttatgttattcaagatttattatt tttttaaaattac[g/a]gattgctgacttcttttgaaaaatagaaatatctggcactactaggcaagtattcccaac/g /DIAPH1/diaphanous homolog 1 (Drosophila) 2068/11/rs7118335/107417165/[t/c]/cctctacagggatcacacctacacccagctttctgtagcccatttt ccttcacaggtgtt[c/t]ccttagtaaatctcttatattaataatctcattagcttcttttgtttctgttttttcttt/ c/CUL5/cullin 5 2069/11/rs11607758/107469157/[g/a]/agtaaagctgttaataaagagtagtttgaatagcttttgccttct tgtgtaacttgacag[a/g]gtaagcatcttttctttgccttggagagttgtcacaccccctgtaatttggatgatcttc 30 /a/CUL5/cullin 5 2070/18/rs3893676/22338761/[g/a]/agttgagaaagtgtcagctccagctactggccaaggaagaggttgcc acaattgtgttag[a/g]tgaaacatctggagtcaatgggatacatattgagcatcaacttcagtgtctaatacaagt/a /KCTD1/potassium channel tetramerisation domain containing 1 2071/10/rs11258541/13789234/[a/g]/cttcccctctctgctggttaactttcgacagctggcagtttcctta tcaaaacagagacc[g/a]tagtctgtgcctcctccgcctcttgcttgacacacacacacacatacacacacacacgca/ a/FRMD4A/FERM domain containing 4A 2072/3/rs1915087/123321481/[t/c]/tcaatttctggaaaactgccttttatctgcccagaattctaagctgg tgccccactgaat[c/t]ttgtgtacctgtgactaaacaactacctcctcagtctgggtgggacttatgtatttatga/c /CD86/CD86 molecule 40 2073/19/rs1725489/43269866/[a/g]/gagatgctcttggcaaatcaaaggctagtctaagggcaaaatactgt gtggtaattaatg[g/a]ccccgatcagaacagcatctgcagggggttcaacaatctccagctgatcagagaatggaa/g /SIPA1L3/signal-induced proliferation-associated 1 like 3 2074/7/rs10267212/99433358/[c/t]/cggttctgtttgttgctgtcactgctgtttgttcttgccagcggcta ggtgtgtagttgc[c/t]tggggctcctagcacgaggcctctgtccccaggcacgcagcgccagtctccggctgttgc/t /LOC100128334/similar to hCG1770601 2075/1/rs10158131/167583234/[a/g]/actacacttgatctgagatgtcaaaacgggatgaggaaaagccagt catgcagaaacctg[g/a]ggtaaaaatacattccaggtagacaaaaagtataaagctttgggaggaagatggacgttg/ g/NME7/non-metastatic cells 7 2076/1/rs4661607/15410445/[c/t]/atattctgtggccctgtggagggccacaaaccattataatatccaaga 50 (167) JP 2010-88432 A 2010.4.22 tttttttcaccc[t/c]gtccccaagaaacaatttttgctccttgtgggtgatcttaccccattgagaatacaagct/t/ TMEM51/transmembrane protein 51 2077/4/rs1121015/178964433/[t/c]/agaatctccacactgttttctataacagttgtaccactttgcatttc taccaactgtgtg[t/c]gagggttcccatttctctacatcctagccagtacgttccctcttttgacaatacatattt/c /LOC285501/hypothetical protein LOC285501 2078/2/rs1013164/51209415/[g/a]/tgataaaggtggtaaaaataaactgtatatttcaggaatgccacatag tccactgggact[a/g]ggtatggatcagtatatataaggagatgcggacttaatgataggtacaagttatttgata/a/ LOC730100/hypothetical protein LOC730100 2079/16/rs2587888/54904973/[g/t]/tttcatgtccagcctgatagaaaatggctcggttctcacacgtctct gccttctctctgt[g/t]gtgatgtgttgtttggttgaagaaaaatttggccccacacgaacagggaaggagtatttt/t 10 /GNAO1/"guanine nucleotide binding protein (G protein), alpha activating activit y polypeptide O" 2080/22/rs5768794/45242042/[a/g]/ccaaaatatgcgcaaataaaatgaaagggacacgcacagtgtgatcc cattttgtgaggg[g/a]gctgctttacttatgcacgaacatgttatatatatatatatatagaaaactctggaagga/a /CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Droso phila)" 2081/8/rs1914826/8258498/[a/g]/tctccagggaagtcttttcattttacaaaactgaaactctccaccttta aacaacttcct[a/g]tttctcccttcccttagcctctgggaaccaccattactttctgtctctgaatttgactac/g/P RAGMIN/homolog of rat pragma of Rnd2 2082/16/rs1559438/81866060/[c/t]/tccagtctttattccatttaggtgtgttcaaatggtgtcatctcagt 20 gagccctcctctg[c/t]ccctcttatttaaaattccatacttccagccctgtctgacccggcactccctatagacac/t /CDH13/cadherin 13 2083/20/rs595292/56254108/[g/t]/acagaggtatttctgacttttcgagctgtactgagactgaacaagtct ctcctctcaatg[g/t]gtatacagtgtaaatgaatacaggtccacacgcacatgcgtcagtacacatgcctgggga/t/ PPP4R1L/"protein phosphatase 4, regulatory subunit 1-like" 2084/6/rs9503013/1652398/[g/a]/aagtgaatctcaagtttcagtgcctctcaaatgttgcttacccaaaatt tcaatattagt[g/a]ttggttgtgaatagaaggaattaaaattacatctccattgtgctcaccagaaccacgtct/a/G MDS/GDP-mannose 4 2085/3/rs11713015/46548322/[t/c]/acttcctcctaccctgcagcattcaggaaaggaaaataatgcccctt ctaggatggcaat[c/t]ggtgtccagtgccttgtcaccagcaatcaccatttttagcccattcattaccagtaggat/c 30 /LRRC2/leucine rich repeat containing 2 2086/9/rs527982/22695094/[c/t]/gtgacagatatgttagttacgagcaatatgcatgatgtttctaggattc tccagagacaa[c/t]tgaattactagctctgtcctgctgttgttattgtacatgtaccacatccttaccactgtt/t/F LJ35282/similar to mariner transposase 2087/2/rs1124134/216526229/[a/g]/acagccaaaaatgagtttattggcataagccaatcagtgtccactct gagagctaagact[g/a]taactgttctgcaagggaaagtctgagtgtacttaatagattgatgggagaaggggataa/a /MREG/melanoregulin 2088/2/rs4853516/191262176/[a/g]/actgaataggaataatacaggtttcatacagtgcaagcctgggtcca gatcttagcaccg[g/a]tacttgactgagtgaccctgactgagttacttaagtactcgtccttcagttgcttcattg/g /NAB1/NGFI-A binding protein 1 (EGR1 binding protein 1) 40 2089/2/rs3771790/74924075/[a/g]/tagagatccatctgcaaacaaaatgagtgaccacccctaaaagagggc agcattttaggg[g/a]aaatgagattctctgttcacaggaacagggccaagactcctgactcctgacgtggataag/a/ HK2/hexokinase 2 2090/4/rs12643937/10187078/[t/c]/taaaaagagaaagggagttgctcaatagatttcatatctgcatccca ggagagttatggt[c/t]gtgttgcatggatgtgtggagggtcatccatcacccacagacaccagacagctccagaga/c /MIST/mast cell immunoreceptor signal transducer 2091/13/rs11617458/97665446/[g/a]/attcctagctactatttagcagctatccaggaactccctgcccaag aagtagtaatagaa[a/g]tgtgtttttatcttttaaaatgatttttcttcataatttctgatggcttatgctttgcat/ a/FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-deri ved)" 50 (168) JP 2010-88432 A 2010.4.22 2092/18/rs7236804/54089439/[c/t]/ctatccactgaattagtatcagcaaacacatttttagttcatcttga tttttatcttcat[t/c]gggattatgcctttatccctttagggttaatgaatttcctactgtgctgttatggaagaa/t /NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" 2093/19/rs1012040/21464254/[g/a]/atcccctcctgaaagcagaatacagtcagaagagtcacatcacctga gtgctgagaccag[g/a]gatatgttacaatgttctctgtgggcgaggaccaggcaaaaaaaacaaatcccctgattg/a /LOC400680/hypothetical gene supported by AK097381; BC040866 2094/2/rs4852814/71687044/[a/c]/caagacgggagctggtcaaatgtggcttcctctgattaggcttatcag agtcctccatca[a/c]ccctaggacagtgaatcaggatgttctggtggcactttcagtctacaccccatctgccca/a/ DYSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)" 2095/3/rs6779957/65408474/[g/a]/caagggacacagcgagcatctcttcggttctttcccaatcctcacttt 10 acaagactaccc[a/g]ttaccaatttgctaactctcgttctagtctctgttcagtcagacattttctttgtaaaca/a/ MAGI1/"membrane associated guanylate kinase, WW and PDZ domain containing 1" 2096/15/rs1618332/39972086/[t/c]/tggtaaataattcagggcctctgtttcctcatctgtgaaatgaaaag cctaagagaacgc[c/t]aagattcttttggcctagaatcctgtgagtctctcttatgacagacagtgacattttcca/t /SPTBN5/"spectrin, beta, non-erythrocytic 5"/ 2097/15/rs1458928/49432291/[t/g]/attatgacagtgaaagaaatctgacctaactggctccatcttgcttt taacctccaagct[t/g]ccctcgttctttcctcaaagtaggctgaactaactttggaaggaacttatagtttaactg/g /GLDN/gliomedin/ 2098/2/rs4852511/79765398/[c/a]/agactgcataggggagtttggtccattgttcattgattagtatgtgct tctttatttgcc[a/c]tgaaatgactatacacatttccttttctttatttatgtctgtaggagagattgaagattt/a/ 20 CTNNA2/"catenin (cadherin-associated protein), alpha 2"/ 2099/4/rs1460016/75321857/[a/g]/ttcattcattgaacagggagttttctagtcctaaaagcaaggttcttc accaggtacaag[g/a]aacacaaatataaataagacatggtcctggctgctggaggtcacagaacagtggatttca/g/ MTHFD2L/methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like/ 2100/9/rs3793543/35788710/[g/a]/aaatatattgaactgaagtctttccttgaagttgtgatgccagtttcc tgttggagcaga[a/g]gttggtctcagtgactatgtggcctgaggcagggcctgagactgggaggtccagcagctc/a/ NPR2/natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptid e receptor B) 2101/17/rs2240570/12823514/[t/c]/ctcatcctcaaactcaatacccattccagcagaggctagggtggaca gaaatccaggcca[c/t]gcccttaaatgtgggccagtttgagtcccagtcccaggcttcaagagaggtgaaggtcga/c 30 /RICH2/Rho-type GTPase-activating protein RICH2/ 2102/7/rs2074354/94778523/[a/g]/cctgaggccaggagccagcatccaatcagctcgagaaacaagagagga aaagaatgggcc[g/a]tctctgaggggcttgagtcctcagaaggttcttcagaagagcatgtggaggagtttgtga/g/ PON1/paraoxonase 1/ 2103/1/rs4113643/209076544/[g/a]/ccctcatcttccctgtccactttctagcactttccaaaaaaagaggt ctagactacagcc[a/g]tgctaaacagagactatccccatcaggaacatgaaaaccatgtataagtcacagcacttc/a /KCNH1/"potassium voltage-gated channel, subfamily H (eag-related), member 1"/ 2104/2/rs4851282/100255818/[c/t]/agccctctttccttttttttcctactaaaattaaattggaatcgttc cacatctgcactg[t/c]gttgaatactgttcctctaaaattcatgtccactagaacctgtggatataaccttatttg/t /LONRF2/LON peptidase N-terminal domain and ring finger 2/ 40 2105/6/rs6918626/4755409/[g/a]/tatgtgtgtgtgtttatttttgcctttatgactcgcccttgcctacggg ataatgacata[a/g]tgcatagttgtctaagtgtgtgatgggttaccctttgccttttgttgtttgcattgtact/a/C DYL/"chromodomain protein, Y-like"/ 2106/8/rs2554507/3755476/[a/g]/ttttgctgtgttagaacccaaaaataatgcattcataatactgtctgct caagttattct[a/g]aaggcaccatttgaatctgacttctttgtaaaatttgtataatgtttacttggttcactt/g/C SMD1/CUB and Sushi multiple domains 1/ 2107/8/rs17328881/3758274/[a/g]/tgtcaaaggatcctgtgaggaccatcgacctgctcaggagtgagaatc caaggccaatcc[g/a]atatcagaacagaggaagcaacaagcacaaagggaaatgcaacttccagaccagaagaag/g/ CSMD1/CUB and Sushi multiple domains 1/ 2108/13/rs10507384/27877480/[g/t]/tcttgcagacagagggaaatacatgatatttcacaaaatagaaaca 50 (169) JP 2010-88432 A 2010.4.22 ttcagttttagctc[t/g]aagtcttgcactagcttttgcttactgggatcccactttatgtacatcagtgattctcaa/ t/FLT1/fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascula r permeability factor receptor) 2109/4/rs11097059/86683004/[a/c]/gatagtggttgagtgtagaattttggaaccaaactgcttggcttgaa ttctggttctatt[c/a]ttttactagctgtgtgaacttgcatgagttacttagttgttttggaccatctgtgaaata/c /ARHGAP24/Rho GTPase activating protein 24/ 2110/20/rs6076248/24587916/[g/a]/cgcctgatttctatcttccttaatagcttgtggattgcataaagcca gtgactaccggcc[a/g]tgatttggggcctgcctgcatggggttctgcccatcgtggaaatgtttctggagagcatg/a /C20orf39/chromosome 20 open reading frame 39/ 2111/9/rs7870419/87474994/[a/g]/cagttacataatgttaaacacagagtatcaagaaaagatacacaaata 10 ggaagatgaggt[a/g]gaaaaagatgagaaattatgaagggccctagaagttgttaattcttttgactatggggaa/g/ AGTPBP1/ATP/GTP binding protein 1 2112/6/rs9490772/123825076/[a/g]/gaaataaatgatttaatatataattagtccctttgtatcaaaaaatt caaagtaataaaa[a/g]cttcattatggcagacaaagcacgcaatgtggggacaacacagaaatccaagaaaggcaa/g /TRDN/triadin 2113/2/rs6712896/45561318/[c/a]/tgttttcttgagatggaatctactcctggtgaagatgctatgaacgtt gtggaaatgata[a/c]aagatatcaaatattacataaacttcattgataaagcagcagcagcaggaatggatagta/a/ SRBD1/S1 RNA binding domain 1 2114/4/rs6830655/178951238/[g/a]/tattgaaaacattgtcatttagatacacactcccagaaaaagtatct attcttccctgag[a/g]aagacatacaggactgccatgggctttgtgtaaacaaagtgatttcaagctgacaagaca/g 20 /LOC285501/hypothetical protein LOC285501 2115/6/rs1535708/6465930/[t/c]/acatccacatatatcaacacttggatgtgatttttgtctctctgcaatt ctgaaatagta[t/c]cagaccacccaacggttcacaactagacttttgttgttgttgttgtttgtttttgttttt/c/R P3-398D13.1/hypothetical protein FLJ33708 2116/2/rs7591633/58725562/[a/g]/aggcaagaactgtggtgaataatgacgaaataacaaagcaataaaagc agcagcagcatt[a/g]tatgtattttgttttcgatatgcaaatgaagggcagacttatttttgtcactttgcctaa/a/ FLJ30838/hypothetical gene supported by AL832565 2117/6/rs9481945/119960123/[a/g]/tacaagcatacattgtgtagtaatcaaatctgggtaattgggacatc cattatcttaaac[a/g]tttgtgatgagaacatcccaaatctacttttctagctattctaaaatatacaatacattt/g /LOC728727/hypothetical protein LOC728727 30 2118/18/rs1470829/29778911/[a/c]/aacatctttgcctcaaaaattagctcaatcaagaaagatatcaatga gtatctaattccc[a/c]tgtagttggactacatttttgagccaggcagtgatcatcggttaatgagactgattttat/c /NOL4/nucleolar protein 4 2119/1/rs11800413/235069500/[g/a]/atggcagtcttcataatagctctgccatagaatcagggtggggcac atgggaagcttcaa[a/g]tataatgatcgttcatctctgtgatacactgattattgtcatgttttatacttcacataa/ g/MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 2120/7/rs10261782/104800211/[a/c]/tactgagctatataaagcataatacaaactatgaaaggttcctttg gagacatacacaac[a/c]accaaataaagcaccccaacccaaacaaaggaaagaaaaaactctctgagcactaactat/ c/SRPK2/SFRS protein kinase 2 2121/9/rs12338076/138261561/[c/a]/ctcctgcatgtttcctagtttctatcttcccgtagatcttggtaca 40 aggtggcaacacag[a/c]gccctgcacagcgaccgtggaactctcccggcacctcaggtgaaggccgcttggacagtc/ a/QSOX2/quiescin Q6 sulfhydryl oxidase 2 2122/20/rs2206481/9723551/[t/g]/ggggatacagactgtcatagcttcatgagaaaaaaaaattaaaatgtg ctgtaggaaagg[t/g]aatgagagtgagaagaaaagccatccaggggatctcatatactgaagatatggtttttct/g/ PAK7/p21(CDKN1A)-activated kinase 7 2123/9/rs7858435/93691236/[g/a]/ggagcttcattcccccatgcctagccaataaaatactaaatcttactt tccagtgagacc[a/g]gtaagaggattccacagtcctgggacacttcctgagagtgggaacacctggtaccaagga/a/ ROR2/receptor tyrosine kinase-like orphan receptor 2 2124/17/rs4790823/1151041/[c/t]/gagtggactgctcacccccggattgtttggaacccccttgaccccagc agcacaaacaca[t/c]aggccagaggcgagcacgtacattcaggtttatttatttccatgctaagacacacagcgg/t/ 50 (170) JP 2010-88432 A 2010.4.22 TUSC5/tumor suppressor candidate 5 2125/4/rs1459157/173975819/[g/a]/agttggagaaacgttggcagcagtgaagtgaatttacatgtattgaa ccattacatcaac[a/g]agtgtgaacttttacaagattctagtagacctggaaaacatggtgatagaactgaaaata/g /GALNT17/polypeptide N-acetylgalactosaminyltransferase 17 2126/18/rs7232558/17487429/[g/t]/aagcactgggattacaggcgtatgctacctgtctggcctgagtataa cctttaaaagata[t/g]gaattaaagttttttttttctcccatgcttagaggtcagtgaaaatgttttgatataagg/g /ABHD3/abhydrolase domain containing 3 2127/12/rs10506026/27620211/[g/t]/gatgaaaactcaaaaaatataatggttcatgtttataaatgttttt gtgtattcagtcct[g/t]gttaggccaaataatcagagctctgtgctgagggagggattgaatatactcagtgcctgt/ g/PPFIBP1/"PTPRF interacting protein, binding protein 1 (liprin beta 1)" 10 2128/2/rs3770283/45610993/[g/a]/ttattaatcaagctttggactagcctgtaattaatatatttgaatgac aacacaacacta[a/g]ggccaattcatgtgctataacaatgctgatcctaaattacgtaggatacacaaaacctca/a/ SRBD1/S1 RNA binding domain 1/ 2129/3/rs4839634/144619509/[g/t]/agttcaaagagcctcattccatgcacttcttgtggtctgctgccatc ccattctacgtgg[t/g]tactcaatccctccatgtactgcatttagaaagcagacctagcaagagagtctgttttga/t /SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 2130/2/rs1504009/125019750/[t/c]/atttcaggccttatcatgtggaaaacccagttggctttgatttcatc tgagtctccgtac[t/c]agcacaaatggcgtcacataaagacctataccagactacagatgttaacccaggacactc/c /CNTNAP5/contactin associated protein-like 5/ 2131/4/rs3108956/110225774/[t/c]/tgcctgttctccaaggttttgtgccactgtcttctctatctactctc 20 tcatccattgcag[c/t]tggggctccatcaccattaccggactgagtcctgcatctaaagagtccgctgagccccat/c /COL25A1/"collagen, type XXV, alpha 1"/ 2132/10/rs7091519/121071784/[g/t]/ggattacaggcatgagccaccacatcttgtcccaacccttgacatt ttagagccaaccat[g/t]ctttgttccaggggtctgtcctgtgcacagcgcaatatttaaccacatccttggcctgca/ t/GRK5/G protein-coupled receptor kinase 5/ 2133/3/rs9846165/69057242/[c/t]/acaatctggctcctactggaagagctgccaaatgatttaaatagtaac aaagattactat[c/t]ccagtgatttgttgcccccaacgatacatacagagaagaattcaccccagtaattttttc/t/ FAM19A4/"family with sequence similarity 19 (chemokine (C-C motif)-like), member A4"/ 2134/1/rs4233366/159425771/[t/c]/ccagctaataagacgccgagccccaaattgaatccagacccgctggc 30 tcccactccagtg[t/c]tctttctactgttgtgaaacccagacccctcaactatcacccttattactaagcactcat/t /ADAMTS4/"ADAM metallopeptidase with thrombospondin type 1 motif, 4"/ 2135/6/rs9322485/155293706/[t/c]/cattgataggatttaacagatttccggggctgagaaaatgggggctt cccacattgtgaa[c/t]gctctgtctgggtaacacagaggccttgtttaggtgaaagcatcttgtgtttctgtgtca/c /LOC729436/hypothetical protein LOC729436/ 2136/9/rs10735625/70559994/[c/t]/catacttcaaaaaagaaatgttttccttttgttgtttgctgactttg gagactgctttcc[c/t]aaagaatccactttcgtttttactactgatctgtgtttttggatagcaccatggcacctt/c /PIP5K1B/"phosphatidylinositol-4-phosphate 5-kinase, type I, beta"/ 2137/1/rs4147592/163866770/[g/a]/cacgcgccttgcatgcccgtgcttcgcccttacagcagagcgcctaa aaccgctacggtg[a/g]ctctgctggggacaaattattcacgtcccactgttctgcaaacccaatccgggaggtatg/a 40 /MGST3/microsomal glutathione S-transferase 3/ 2138/5/rs1500508/17317096/[a/g]/tggggatgttattagaattgctaaatatgagccttggctgaatcagac acc[a/g]acaacaataatttcaacaatggaaattgccaccaggcactgaagacttgacaagtcactg/a/BASP1/"br ain abundant, membrane attached signal protein 1"/ 2139/8/rs11993947/125040636/[g/t]/caataaattagtgaatgagtgctgtagaagaagctttagctgactg cctttctacctcga[t/g]gtctcaccctacagaatgtacagaatgaacgcccctagagggaggcatatgtgatttgct/ g/FER1L6/fer-1-like 6 (C. elegans)/ 2140/10/rs16928929/72910079/[t/c]/ttcagtctgcagcgcgtctgcccacattcccgttctgtccttaccc cagtctggccctat[c/t]gtttctgcagcagtttattcaacaagcacttaagccaggctgtactctgggaggacagtg/ c/CDH23/cadherin-like 23/ 50 (171) JP 2010-88432 A 2010.4.22 2141/20/rs4814489/16327705/[t/c]/ccctagtttggcctaagagggggaaagtaataaagagcagaagaaag ctctgaaacaagt[t/c]tgtttgagtaggaggtgccatcaatgcttttgattcctgttaaaactggttctggagagg/t /KIF16B/kinesin family member 16B/ 2142/6/rs549262/116860688/[a/g]/atgatccttgcattttctgtcgtttaacttccagcagtacatactggc aggagctactcc[a/g]ggaattaaattttcttcctgtagaaactcagtctctcccctgaacttcgtatatagtata/a/ DSE/dermatan sulfate epimerase/ 2143/7/rs940871/6630195/[g/a]/gctggggaaagaatatctgagacgacgtttgggagcaatgctctttacca cgttcaccaa[a/g]tcgtctggggcaggggttgtgagctgcagcagttgctggtgccttgtgggaaggtggggc/g/DK FZp547K054/hypothetical protein DKFZp547K054/ 2144/18/rs2644254/32460438/[a/g]/gatattatatgtatttaaagtataaagtttgacaaaatctgccaaac 10 ccagagtggttct[a/g]tagtatagaggtacaacaaaaggctggccatgcctgctccagagtctgggtccagttgta/a /FHOD3/formin homology 2 domain containing 3/ 2145/17/rs4889875/76266095/[t/c]/tttgctgggcagttttctcttcctcaacttgttaaattctattcatg catcgagtcttgc[c/t]gttgatgtcattttctttggaaactgttcctaaatccttaatcctttctaccttacaaaa/c /KIAA1303/raptor/ 2146/3/rs2229362/188928905/[a/g]/ccgaagtgcacgtcctgcggctctcagtccccacagcatgcagagat gtgcctccacacc[g/a]ctggccccacgttccctgaggagatgggagagacccagtctgagtactcagattctagct/g /BCL6/B-cell CLL/lymphoma 6 (zinc finger protein 51) 2147/3/rs9827569/188935176/[t/g]/cattagctggctaaattagtttgtacaaagaaagagtaacaatgatt gaccatgcaagtg[g/t]taagacagtctaatacagaggtgaaggatgaggactaggagtgatgtagagggaactggt/g 20 /BCL6/B-cell CLL/lymphoma 6 (zinc finger protein 51) 2148/6/rs2757596/7545426/[a/g]/tccccattaattcaaaaccctttgacgagtaaaaatggccatatattgt tatgtatagcc[a/g]tgttaaaccatggcctcagattcactgcagctctcctcttaatatgtagacaagtagtac/g/C 6orf151/chromosome 6 open reading frame 151/ 2149/6/rs17056048/96639411/[a/c]/gcacactatggtcttcagtcccaacttctcattactgattcccattt gtatgtcttcact[c/a]tccacagacatttactctaatgtttgatatacatccctgtttatatatataacccttgca/c /FUT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)"/ 2150/6/rs12200614/96651135/[c/a]/tggagttcttacacaggtttataagaatttacctaatctgtcccatc actcccttaatct[a/c]tctaatcttgtctacaagtttcacttctttaagtccactctcactgctctggtcccctca/a /FUT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)"/ 30 2151/11/rs10835169/27328815/[c/t]/attttttagaaatgtgcaaataattgcttggcagcaaaacactagt ttcctagactaaac[c/t]tcagctaaattaccctcattgaaatcaactttcccacacataaattttggcatcactcta/ t/CCDC34/coiled-coil domain containing 34/ 2152/11/rs2291023/27338327/[t/c]/tcaagaaaggcttgacaagtggccatttgtgaacaagatatttatta cagcatggttttc[c/t]taatggatagtggtagaaaaaccaggataaagctgaataaacagcaggcccagagcacat/c /CCDC34/coiled-coil domain containing 34/ 2153/13/rs7986087/94713746/[t/c]/cacacaaatatataaataatatgtgttgatctgtgtatgcaaataca ttctagctttgtc[c/t]gcttagagttcctagaagcaatgagatcccataacaataaatatgcctaggccgggcaca/c /ABCC4/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 4" 2154/17/rs2447447/58754541/[c/t]/aaaggccctgaatgagatctccctgtccctctactgtgattatgctt 40 tagaagaaatatg[c/t]aatgttaagtggagacacgctcgagagatgccaacctatcaaaatctttgcttcaaatgg/c /TANC2/"tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2"/ 2155/13/rs984299/108254079/[g/a]/agtcttgtttggtaaatgtggcatattgcctcctggtatgctttgca aaaccatcaccaa[a/g]tcttagtgtttttcagctatgaaagcacaggagcatcccaggctccacatttgggagtct/g /MYO16/myosin XVI/ 2156/2/rs1529409/71684197/[t/c]/cacttcctgccattagggaatccccagaccgacagcggacactatttg acattttcagtg[c/t]aatttggacttgaagtgcagagtcaggatgtgg/t/DYSF/"dysferlin, limb girdl e muscular dystrophy 2B (autosomal recessive)"/ 2157/3/rs6774934/190864951/[g/a]/cggtctttggtactgccatcctatttcctaactgaggaagataatgc tctgtgatgcaac[a/g]tgcattgcagcatgccacattgcatagacatctgaatcccacaggaaccagagcctgagt/a 50 (172) JP 2010-88432 A 2010.4.22 /TP63/tumor protein p63/ 2158/1/rs364482/45224064/[a/g]/gcatgagtgctatgatgcaggcaagtctgagatgcggtgaacaccctct ccaaagcttgg[a/g]aggcagcgagactcgttgccatgattcccgtcagccatagtcgtggcagtgacatgagca/g/E IF2B3/"eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa"/ 2159/10/rs2297325/24863082/[g/a]/gcagttattaccatggaaaccagagtagaacaagtgcagtaaaaaca atgtagattgaaa[a/g]ttctccctactccaaagaaaagaggaaaatttatgggttggcacaaagccattggtacgt/a /KIAA1217/KIAA1217/ 2160/10/rs945525/56182893/[c/t]/cacgtctctattttcttattccatagcacccaacatcctctggtgcta gatgtatcttta[c/t]aatatataccatggatgtgcaaacattgatggaatatttatatgtgggtaactccttact/t/ PCDH15/protocadherin 15/ 10 2161/10/rs10763136/56181286/[t/c]/tcttgatattttcaaatactcaagagtaatctagcacaaagagctc agaaatttgcaaca[c/t]aatatattgcacccagaaaaaacccttaaaaccgtctagttcaatcatctatgttagaga/ c/PCDH15/protocadherin 15/ 2162/14/rs12590618/101878083/[t/c]/gttcccctgtgggatggaggtgcactctggccagagagaactgga gagcgtggttgctgt[c/t]ggcgaagccatggcttttgaaatttccaatgggagccatgagttactgtctcagggacag /c/C14orf131/chromosome 14 open reading frame 131/ 2163/1/rs10864639/6769350/[t/g]/ctgggttagggcgagctcatttcctaaataccctttgagttgccctcc ttttcttatgga[g/t]acaactggacgttcaccgtgctcctttcgccatttgtgtgtctacactgacttgttctct/g/ CAMTA1/calmodulin binding transcription activator 1/ 2164/1/rs876295/15569770/[c/t]/gcatgctgcggatcatcgggagtatcacagccccagtcatagggacaga 20 gtgtgagcacc[c/t]gcttccagggcggcccaatgaaggctgttttcactcaaagacacactcccatcagatgct/t/F HAD1/forkhead-associated (FHA) phosphopeptide binding domain 1/ 2165/2/rs6749075/47626454/[c/t]/aaatgctcagcatagtgctaatagcatgaccacctcaaaatgcaagcc atttgtgctaac[t/c]gatggacagcaaggaacagaatttctaaagagagtagataagaaaaaaatagagaagagg/t/ KCNK12/"potassium channel, subfamily K, member 12"/ 2166/15/rs2414491/55253067/[g/a]/agaacaagaacacaaattaccagaatctggaatgaaagagaggttac tgctatgaatcat[a/g]tatacattaagaatataataaatattataacttagtaaatttgacaacttagattaaata/g /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 2167/6/rs9394866/42182084/[g/a]/ctgccgccaagactcttttcaggaacacctgggggagtgtcctttgct 30 ggcaggctcagg[a/g]gagtctccttctcaggcaggcgggggcccttcttgccctccttgctctgaggggccactg/g/ LOC100128918/hypothetical protein LOC100128918/ 2168/4/rs12507758/87570764/[t/c]/atttaaataaacgagtagttatataccatagagttgggtcaagagct atgaaggctatta[t/c]aggattgcaagaaaggcatataatctaaggagtacaaaaattgtctctacaaaagcgcca/c /MAPK10/mitogen-activated protein kinase 10/ 2169/9/rs2487052/106726226/[t/c]/acgtgaaaaacatttcaaacagtacttgccacacagtgctatataag tgtctattcaaca[c/t]tgcaataactttggccattcatggttgtatccacatgcagatacgaagatggttgcattt/t /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 2170/1/rs358689/91217121/[g/a]/acagcatgagaaaatgtcaacgtctaactctgtgttcaaacattatggc agaagctgcag[a/g]aaggaaaagcaacaaattgatccctgtggggaagaacctcttcttgctttggacttgcta/a/Z 40 NF644/zinc finger protein 644/ 2171/2/rs6754391/24222523/[t/c]/caccgtttaactctaatagtcatgatgtgtattgtaactacccctgaa aaactagcctga[t/c]gagcatgagaaagatacatgagtgaccttttaagcttgtggtagaatttcactgactagg/c/ LOC375190/hypothetical LOC375190/ 2172/18/rs988920/3983987/[g/a]/aagggggtctctgtggttcttctctccttatctttttacttcactcacc acattcttacc[a/g]aaccaaaaggaaaacaacagtggagggaaagtcttacacatgtcaggcttttagacagaa/a/L OC388458/hypothetical gene supported by BC040718/ 2173/2/rs3770313/80643798/[c/t]/ctgggaactggagagtacatgtgcttctttgtcacttcaaggacatca gagaccagcatc[t/c]gtggtaatggcagtgtagtaaattaggggcctacatattgtgtctagcagagtcagtgct/c/ CTNNA2/"catenin (cadherin-associated protein), alpha 2"/ 50 (173) JP 2010-88432 A 2010.4.22 2174/19/rs8111180/43322000/[g/a]/agtgatagtacctttccccacctctgcccgggcctggcatgtctaca ggctctgatagac[g/a]ttcatattgttattgttcctcacctggtgcctggtgagacattggcagctgccagtccaa/a /SIPA1L3/signal-induced proliferation-associated 1 like 3/ 2175/15/rs510949/38041447/[t/c]/gtgaaattctgtatttcaatatggggagtcctgatcagctcatggtgc acaaagggaaatgtattggtgagtaaactagcaaaatctattcatattattgtaatggcaaaagttaatcac[a/c/g]a aggaatgggatggattagacactgtgtcattcagaccagtgcagtccaaggaagaccatcaagctggtagtcattctggc tcccatccttaatgactggaatgagaaatcactcaggtt/c/EIF2AK4/eukaryotic translation initiat ion factor 2 alpha kinase 4 2176/15/rs11070241/38072094/[c/t]/cactgtccctcctcttcaatagcaaagacatccttgtgtagaaccg aatgtgtggccata[c/t]gtgacttatggttattcatttggtacaatgcatgctctgcttcctgtgagtggcatagac/ 10 t/EIF2AK4/eukaryotic translation initiation factor 2 alpha kinase 4 2177/17/rs2949942/62929282/[a/g]/acaatacaatacaatacaatgcaatgcaatgcaataatcttacttca cacaaacttcctc[g/a]agtacccaaaactagaccaattctccctgtcagatcctctcaataatatcttgtacttcc/g /PITPNC1/"phosphatidylinositol transfer protein, cytoplasmic 1" 2178/10/rs1911314/67880428/[a/g]/tgttccctagaatatttacacttaaaagaaaaatcttgctccattga tataacatctcaa[a/g]gaagaactagcaatagaagaaaattgtgctaaactttagaccctgttgtagcaatattta/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 2179/2/rs10497422/174561031/[a/c]/agaattcagattggagttctcctccagaactcagcaattgagtaaa caatacgttatctg[c/a]tccataaagtgtgtaaaacaaactcaccctagtggctctctttttaactttctctgtgat/ c/LOC100129312/hypothetical LOC100129312 20 2180/10/rs1911326/67889985/[g/a]/ttttaatcatgatggcttttatgcttagtttaatagctggtacagca agccttcactcac[a/g]ctcttctgtccaattgttttaaacagtttaatttaatgctgccctcaggctgagaaactt/g /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 2181/14/rs2075140/75134377/[g/a]/gattgagggcagaggctgggctgaggctcatgattttgattcaccta aggtactgaaaac[a/g]tcctgaaaaccttagggttggggagttgaggagccctaatgggatatgagcttgaaacca/g /FLVCR2/feline leukemia virus subgroup C cellular receptor family 2182/14/rs3784006/75141447/[g/a]/ctcaccaaagaaaaaggcccttagctctgtagaatcaagggagggga gatattccactgg[a/g]ttaacttgggaatggtgctaggtagaaagaagtcaggaggtcaagaaagaaagaagagga/g /FLVCR2/feline leukemia virus subgroup C cellular receptor family 2183/16/rs876457/11051227/[a/g]/caggagtagaggggaagggagctgcaagtgaatgagtgaggcaggaac 30 tgccacccctgc[a/g]gggttagaggatttggagtgggggacctcaggcttctggaggaaagtacttaaagtgtcc/g/ CLEC16A/C-type lectin domain family 16 2184/9/rs10491897/28329748/[a/g]/ctgtaggaatgaagttctaataacagatcttcacattgtttctacca ttgcctggaaaca[a/g]taaataatattcactactggttttcaagtatatgcagatttcattatgataattaaagta/g /LINGO2/leucine rich repeat and Ig domain containing 2 2185/3/rs7374260/197642729/[t/c]/agagaattcatagaatggctttagggcctttcctccaggcggtaaga ggatctgcgtgtg[c/t]ccttcgcaggggtccaaagggagagaacctaggcctagggtttcggggataccgacaccc/c /UBXD7/UBX domain containing 7 2186/17/rs2286916/63166025/[a/g]/tgtctccagatgtctggcgtatttgtttgatgtataaattgaacatt tttttcaatcttc[g/a]tgatgggtttatataatagaaattttttctatcaaaatgataaactatccattttttttc/a 40 /NOL11/nucleolar protein 11 2187/5/rs11741062/80406528/[c/a]/ctcagtgtcagtgaagggaagagtcagggagttatcaaggtgggaca tggtacagccatt[a/c]acttttgctctaaatgagatggggagacattggtcaggttttgagcagagaaggggtgtg/c /RASGRF2/Ras protein-specific guanine nucleotide-releasing factor 2 2188/2/rs6753354/173758560/[a/g]/gaagccttgatttttgttgattctgtttcaaattcagctatgtacct ttcagtttaacct[a/g]tgattgaatccactggagcaatgatatgttgagaaatcagagaatgaatattttaagcaa/a /ZAK/sterile alpha motif and leucine zipper containing kinase AZK 2189/5/rs10515200/74523470/[a/g]/ttctaacaagttaatacatacatatatgtgaaaggcattaattgttg actccagcttatc[g/a]catttttaaaactttttcttttgaaataatctcagacttacagaaaagttgtaaaaatag/a /ANKRD31/ankyrin repeat domain 31 50 (174) JP 2010-88432 A 2010.4.22 2190/5/rs2219745/74542414/[t/c]/tgcaaaatgacaaaaatacctacaacataatgaagccaaaaattagta tacttactgtaa[c/t]agagcttgatttcgttctgtttcatcttgagactgctaggaaaaaaaaaagttttttcca/t/ ANKRD31/ankyrin repeat domain 31 2191/11/rs3802813/125667678/[a/g]/agaggcccaactccccagaaagcacctccagcgatgcttcacagcc tacctcacaggaca[g/a]cccactacccccaagcctcagctcagtcacgtctcccagcctgccacccacacatgcgag/ g/TIRAP/toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2192/10/rs10997109/67849976/[g/a]/gagtatataagatactcaaacaattcaacaataaaataagaatccc attaagtaagaagt[a/g]ggcacagaacattaatagataattccgaaaggaagacatgcaaatggccaacaggtacat/ g/CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 2193/10/rs6597743/127869846/[c/t]/cctgccctcaagtgatctgcctgcctcagcctctcaaagtgctggg 10 attgagtcaccggg[c/t]ccagtctatgaggagcctttatggggttataaaccaggattaccattgtttagtttatgc/ c/ADAM12/ADAM metallopeptidase domain 12 (meltrin alpha)/ 2194/18/rs2586205/17264134/[a/c]/gttatagactgaattgtctccccgcaatccatatgttgaggccccaa ttcctaaaacctt[a/c]gaatgtgactgtatttgaacataggccctttaaaggggtaattatgatgagatgaggtca/a /KIAA1772/KIAA1772/ 2195/16/rs1463243/6121345/[t/c]/catagtctctatctccactactcaactgttaccttagtgcaaaagcag cctttgacaata[t/c]gtagataaatcagtacagcaaagtaccaataacattttgtttacaaaaacaagtggcaat/t/ A2BP1/ataxin 2-binding protein 1/ 2196/9/rs4742236/676753/[a/g]/tgaggggaaatggcagcatcacgtcataagtgcaatgattgttacctatg agcctatccg[a/g]taagggatctgagtgggcccaagcatcacacacgtgctggagctgagtgttctctgagga/g/KA 20 NK1/KN motif and ankyrin repeat domains 1/ 2197/4/rs983560/173182862/[a/g]/ttgaggaaaataagatattctttaggagccccttatttggaaacatta tttcctttacag[a/g]cattatctgtaaaaaccccttgacctacctaaatgagagtctattagtgtctgatgtgct/a/ GALNT17/polypeptide N-acetylgalactosaminyltransferase 17/ 2198/18/rs7505175/8617957/[t/c]/attaaataatttaagtggctatattaaatacagcaaataagaggcttt gaattctccaag[c/t]gttgttgtatcaccaaactgggaaaacagaattgcaggaatttttcaattgcacaaaaac/c/ RAB12/RAB12/ 2199/17/rs8072812/58498812/[a/g]/acccaaacaagaagcaaacttgatgggttcagtagcataatggaagt gactgcagaagga[g/a]ttagtgaacttgaagacagatccatagaaattatccaaatctaaacaatagagagaaaag/a /TANC2/"tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2"/ 30 2200/10/rs667254/6604781/[a/g]/accaaatttggctgagcagatgtaattggaaaccattgaatgctttgtt tctcattccca[a/g]atttactattgattaatctgtgttctttcttccacatgtgagaggttttgatacaagtga/a/P RKCQ/"protein kinase C, theta"/ 2201/10/rs500766/6590596/[t/c]/ttttcatatgagtttcaacagattaatgaaaagaaaagtgcttttgaca tggcatgtatg[c/t]accattgttctctggcttgtgaataaggagtaaagatggaggcaaaaatggagatggaag/t/P RKCQ/"protein kinase C, theta"/ 2202/7/rs2023988/70952217/[c/t]/gtattgaatatcccatccttagcccaagtgatttagcacaagtttcac gctaaattccca[c/t]gtagacctgggcatatatatggactcccagtccattccattgatctagactctattctat/c/ CALN1/calneuron 1/ 2203/2/rs3731746/179139243/[c/t]/gaattgttgtaagagctggtggatctgccagaattcacattccattc 40 aaaggtcgtccaa[c/t]gcctgagatcacttggtctcgagaggaaggtgaattcacagataaggtccaaattgaaaa/t /TTN/titin/ 2204/3/rs7630653/29939556/[a/g]/tgaatcatgcccacagatgctattgcttcattatcccttaatctaggg attacctccatt[a/g]gctaactcgatgacatgtgagggtttcaaataagattgcctctcccttgtaacatacatc/g/ RBMS3/"RNA binding motif, single stranded interacting protein"/ 2205/15/rs12908295/47576537/[a/g]/atgaatcctaaaccaccagtctctattactaattacacctgaacag tcagcaatcacttt[a/g]gaagattattcagcacctatggatagaagtctttaaagaacaaaatgctggaaaagggga/ g/C15orf33/chromosome 15 open reading frame 33/ 2206/3/rs9881879/156358614/[t/c]/tgtcctacttttgtgatctattgttatctgaaacattaatttcatat atcctgttcctct[c/t]ctctgtaatcacagtttaaaaacaacttggattggcaccttttctatttcaatattagga/t 50 (175) JP 2010-88432 A 2010.4.22 /MME/membrane metallo-endopeptidase/ 2207/7/rs7791492/32486724/[c/t]/agccagtgttataaattctgtgctgtgaaggcaagactgagatgtgac tgagaaggtcaa[c/t]aggcacccctcatggtaacctgttaaggaacctggcctttcattgtatagaaggtaactt/c/ LOC442525/similar to ADP/ATP translocase 2 (Adenine nucleotide translocator 2) ( ANT 2) (ADP 2208/10/rs220346/24670266/[c/a]/tttttttttaggaccggaagagaaagaatcatcttggcttgacaatct tccaactgacct[a/c]ctgatttccatcccaatgaaggatttaatcacgactttgcctgtacatagaagacatgga/a/ KIAA1217/KIAA1217/ 2209/14/rs2272588/77093467/[a/g]/accttgaattgaaatccaaaatgtaacaaatgttcaaaaccatcgaa acttgactaaagg[a/g]cggtggtggctaactcagttcattagcttccttataaaatgaccagtgtctcatgttaaa/g 10 /SPTLC2/"serine palmitoyltransferase, long chain base subunit 2"/ 2210/7/rs4722804/28498989/[t/g]/tttgtgttatatacgcatataaaacaaaaattataattagttgtttga cggaaagactag[g/t]caactcagtctctaaatcacacgtggtagtgctatgtatttggtgcagtcattacacagt/t/ CREB5/cAMP responsive element binding protein 5/ 2211/13/rs1408165/42366368/[t/c]/atcagatagaaatctgtaaattggtcacaatacaacaaaataatcaa gtgcttgctgacc[c/t]agaaaatctagagaagatcttcctttaataaatacttgacagacaaaagatcatgtttga/c /EPSTI1/epithelial stromal interaction 1 (breast)/ 2212/3/rs3772158/129998832/[g/t]/gagacaatgtgtgatttttgtgtgataaggttaaggtaacctaaagc taatacaaaaacc[g/t]tcccccccatagccagtgatatcacctttcttggccacaaaggaacatgttcatatttgt/t /RAB7A/RAB7A/ 20 2213/8/rs10958392/54917377/[c/t]/tacacaaagtgggaacataatttcttagaagacagtgctttcctttt caaacaaaattca[c/t]agtatttgcaaaatcaaaattcggagagaaagttttagaacaaatacatattacaattta/t /ATP6V1H/"ATPase, H+ transporting, lysosomal 50"/"57kDa, V1 subunit H" 2214/18/rs288980/16863578/[c/t]/tgcagtgaggtatttatgatatcattgttaataaaaaagggcagtaat ataaaaaatgga[c/t]atgacatcttcaagaattataaatttgatgtggaccaagtcttccagatacttaataata/c/ ROCK1/"Rho-associated, coiled-coil containing protein kinase 1"/ 2215/1/rs6656188/172419311/[a/g]/cagaaagtacagacagttcctgcatacccctgcccttacacaacgtg cacagccttcccc[a/g]ctatcgacattcatacatcagggtagtaaatttgttacagctgatgaacctacttgacac/a /RABGAP1L/RAB GTPase activating protein 1-like/ 2216/2/rs17739099/75645775/[t/g]/atgtaacccgtgtgtctatcaatgcagttcagcttaactgtcatttc 30 ctggagactgctc[g/t]cccttcacagagaactgtcctagacaccataggcaaccttgctgcacgatacactcagct/t /TMEM166/transmembrane protein 166/ 2217/6/rs324356/155648017/[c/t]/tactacaacaaataagcagaaacttacctctggtttggggacaaaagc ttgtcctggaat[c/t]gtaaagatgtgtcgaacattgcagaggtactgagccataacagagaggcgactacgctgt/t/ TFB1M/"transcription factor B1, mitochondrial"/ 2218/6/rs324360/155651442/[g/a]/attcaaaaaagatcttatttaagtatttaagtatatttcacttagaac acatccagaaac[a/g]tcaggggaatatgtgtcccaatccattaacctgacccattcaattcaatctttgtagcat/a/ TFB1M/"transcription factor B1, mitochondrial"/ 2219/12/rs7315271/37450998/[g/a]/aattagatccctgctgtactctcataatatatttgaatcacttgtca catatcatgacat[a/g]tattacctgcatagtcagccgactaatgtctctctttcccacaaactatgtgttcattaa/a 40 /CPNE8/copine VIII/ 2220/8/rs3928672/141641349/[a/g]/gtaatgctgtgttcccagtttcgtgctgcatgcatgtctgcaactct agggaccatcacc[a/g]ctgctttttgtgactgttggggacgtcctttttctcaggattactcttttaccacaaatg/a /EIF2C2/"eukaryotic translation initiation factor 2C, 2"/ 2221/1/rs4607842/244380346/[g/a]/taactgtgggaacaaaaatgactctggtaaagtgaagttaattacat ttaacttattctg[a/g]agggttgtattttctaccacagctcacttatacagaccactcccattctgtaatcaggcc/a /SMYD3/SET and MYND domain containing 3/ 2222/9/rs3118571/136457999/[g/a]/tccttctcggatgtaagagaaaaataggagaggaacccactttacag taacctttggggt[a/g]tcttcaccttcctaagtgctccatcgctgcaggaaggagggctcctggccctgtgatgtg/a /RXRA/"retinoid X receptor, alpha"/ 50 (176) JP 2010-88432 A 2010.4.22 2223/18/rs8095324/22385657/[g/a]/cccctcgaccaaaagaaaaaaaaaagttgcttaatttttaaaaccca ataacacaaaatt[a/g]cagtggagttcataaagtagttcaattccaagtttaataaatgatcccttaaaaacatcc/g /KCTD1/potassium channel tetramerisation domain containing 1/ 2224/18/rs9948310/22390252/[c/t]/ggagactgccttggagaggggcagagaagcaggaaacattgtgacct ggcccctctcttc[t/c]gtgacctaagtttgcagagccagggcatcattgctcccaggggaagcctcaccattcttc/c /KCTD1/potassium channel tetramerisation domain containing 1 2225/19/rs2965241/58447656/[t/c]/tatttcatgggtttaattgatcccaaggatttaactcttttccagaa aaatattcaaaaa[c/t]atgaaattacaaatagctattactcttggaaagcatgaaagggggtcagctgtggagatt/t /ZNF677/zinc finger protein 677 2226/6/rs9394865/42181936/[t/c]/gggcttagcctccttctctgctgctgaggagagccgggcctccagctc 10 attccggatctg[c/t]cgcacactgggagttggagagtcttggggaatgtagtccacagagggcagggtcaggctg/t/ LOC100128918/hypothetical protein LOC100128918 2227/16/rs7194545/11031797/[t/c]/tcccatcaccagtgtacaagagttctagttcctttacctcctttcca acatttggtgtgg[c/t]cacctttttagttttcaccattctaataggtttgcagtggtatcttatgatcttaatttg/c /CLEC16A/C-type lectin domain family 16 2228/3/rs6763011/195548028/[a/g]/cttgctagccccattggtcattgtttctcaaaggctatttccagaaa gtactcccctgga[a/g]tgatggaccagacaacgctggggcctatgggtcccgagaccagctggcctcctcccaggg/a /CPN2/"carboxypeptidase N, polypeptide 2" 2229/2/rs1514687/1416995/[a/c]/ataaattaattaaaaagacatttcgcttacttgctctgcatcataggaa gcaccaatatg[a/c]cttttgaatgcctgcattaccatctcagtatcttatgcccatagagtgctttagagctga/a/T 20 PO/thyroid peroxidase 2230/1/rs2809295/214619647/[t/c]/atgacagcaagttgtcaacagatttcccaaggatttctctgaggaac tagagacttacaa[c/t]ggggagaaagtgtcattccatctgaatccaaccattacatcaattgacctgaaagctaga/t /USH2A/"Usher syndrome 2A (autosomal recessive, mild)" 2231/11/rs231906/2709185/[t/c]/gtgctggctccctttcccaggcctctcccgctgacacacagccggaatg tgccagactca[c/t]caaggcctgaattcccgaggggtctggcatgccgactgtgggacgagggcatttgggcat/c/K CNQ1/"potassium voltage-gated channel, KQT-like subfamily, member 1" 2232/1/rs11119751/209729844/[t/c]/agagaaggcccaggtggtgaggcctcaggtttacagagcagagtgg atgatggggaagcc[c/t]tcgcacgttctgtctctgccttttggtgtcactcacccacgcccgttatcttccattctc/ c/RD3/retinal degeneration 3 30 2233/19/rs8112883/7130320/[t/g]/tatgaaacccaaacagtttgtgggaatcccccaatttagagccagtta gtcagaagtgtg[g/t]gtggctgggggatccccaagatgctgccagtgtctgaagcaagggaaatctcatggaggg/g/ INSR/insulin receptor 2234/13/rs10492458/29237472/[t/c]/attgtttaattgcccaattaagcaactaccagattctttagtcaac actaacagaattca[c/t]atttcagctagtcaacaaagcatataaatatttaacatctcttgaagataacattttagt/ c/UBL3/ubiquitin-like 3 2235/3/rs12330894/152854479/[a/c]/actaagagctaataatatatagttgttatatgaaaatgtttttatt ggaaagaagaaaac[c/a]tgatcacttgggtctcttcctgtcttccacaagataaccattatcaataatttgattaac/ c/LOC730049/hypothetical protein LOC730049 2236/3/rs6764062/152846534/[g/a]/tctgccttgagtccactaagactaatctcattatgcctcttattatt 40 gtttttgtcagtt[a/g]tcacaagaagcaccagataccagggtcagtctttattttcacaccgtgccaagctctgca/a /LOC730049/hypothetical protein LOC730049 2237/19/rs331679/6799220/[t/c]/aaagaaggtgaaaggcacgtgggaaccagcaggggctcagtaaaaggtg gatgctattac[c/t]gtacacttctataaagtaaaacctggataccctttttcccaggcccgcagggcccaggcc/t/V AV1/vav 1 guanine nucleotide exchange factor 2238/1/rs2577127/218417374/[g/a]/ttctttgtccatttggtgaggtcgtgtttccctgaatgttctcgatg cttgtggtagtac[a/g]atggtattgtgcattgatatattaggtatgtactttagtcttcacagtctggctttgttt/a /RAB3GAP2/RAB3 GTPase activating protein subunit 2 (non-catalytic) 2239/2/rs7598826/100839866/[a/g]/gggcaggtgatggagagtggtagggcgtgcatttctgccagaattgg gagtggctggtgc[g/a]gcatggataggacaggctgtccaagcacaagcttaagatgttgtcattcctggccgggca/g 50 (177) JP 2010-88432 A 2010.4.22 /NPAS2/neuronal PAS domain protein 2 2240/3/rs1872394/7655566/[a/g]/cagaccaaaagcatttgggagattctgccaaatc[a/g]ttagctctct cttccccttgatttctcttgacttccaatccttgactgagcctttagata/g/GRM7/"glutamate receptor, m etabotropic 7"/ 2241/3/rs1129055/123321009/[g/a]/cctaatcttttcttctatttctccagagaaaaaatccatatacctga aagatctgatgaa[a/g]cccagcgtgtttttaaaagttcgaagacatcttcatgcgacaaaagtgatacatgttttt/a /CD86/CD86 molecule/ 2242/4/rs3796716/68175708/[t/c]/cagcagtaccatacctgaaacttcggtgtgagctcctttagggagttg tgaaaaagccca[c/t]agttcatgttaaaactgtagttaaattgctcaggagaatttattaccctcagactttaac/c/ UBA6/ubiquitin-like modifier activating enzyme 6/ 10 2243/13/rs3764124/112945321/[t/c]/tggtattgatttgcttttgtagacttttggaacagcgatcgtaatc aatcctgagaaaga[c/t]aaagacatggtccaagacctgttggacttcaaggacaaggtggaccacgtgatcgaggtc/ c/CUL4A/cullin 4A/ 2244/5/rs4301212/74444735/[a/g]/ctggaatgctttcaattcactctgccctgatccttctctttccctatg agagagagaatc[g/a]tggagtgggctctggaaccagactttcagggtgtaaatcctagcttcacctcttcctatc/a/ LOC100131794/hypothetical protein LOC100131794/ 2245/4/rs10518142/77061898/[t/g]/cagtggaggaggtactgctgggaagcatcgcatgaattgaagctaaa gagacaaacacaa[g/t]tgagtggtgaaagtggtggttgcagggtgaggagtggcagtggggaggagggttctagtt/g /ASAHL/N-acylsphingosine amidohydrolase (acid ceramidase)-like/ 2246/4/rs4864723/53681603/[t/c]/tttcacagtccacactgggagaaatagacagtatcaggttagagagac 20 tgtcaggcgtca[t/c]acccaactgaacccaagaggacattttgcttggatgagaaaaagaaaatttattgaaatt/t/ SCFD2/sec1 family domain containing 2/ 2247/1/rs943762/176175475/[t/c]/cctgagcgtcagctatgtatatgctcagttcatcattttgggtacctg ttgttgttcctc[c/t]ggctcccgaaatatctgagcgagtaggatgaggatccccaatgtctcctgctaccttttg/t/ SEC16B/SEC16 homolog B (S. cerevisiae)/ 2248/1/rs804125/14984514/[g/t]/gttctcttggggtccaatcagctatggcctaagagtggtgtcatggaga acaaatatggc[t/g]ccaaatcttaccctgtggacagaatggatacctcaggggaggcccgttcctctggcgctg/t/R P1-21O18.1/kazrin/ 2249/5/rs165359/150841229/[a/g]/atttatgcgcgttcattttgttcttgcttctctgttctttcagatctt tcagcaccgttg[a/g]ttagtatgtgattttagatctttaattgatttttttcatttatattcataaattttaaca/g/ 30 SLC36A1/solute carrier family 36 (proton/"amino acid symporter), member 1" 2250/6/rs2744294/25404585/[g/a]/ctccttgtggagccctgtcctccttgctgaggccctcaagagtgcagc ctgcttttctgt[a/g]tcctttcaaagctaccattgtgtactatgttgcttgtggctgtcttttctttcaagcctg/a/ LRRC16/leucine rich repeat containing 16/ 2251/7/rs798309/77796058/[c/t]/aatatttttcttctctcatgaggacacgggagaaaatatatccagtatt ctttcccacca[c/t]cccccatagtcagataagaaaatacaaaagaaatacaacaaagaagtaagaggagtgaaa/t/M AGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2"/ 2252/11/rs1993225/5797644/[c/t]/caagcattttttgttatcaaggcaggggaaaagtgctaatatttgaga tattgttaaaaa[c/t]ggaaagttaagctactgataagaactggtcatattagggtgatgctgtaattatacccat/c/ OR52N2/"olfactory receptor, family 52, subfamily N, member 2"/ 40 2253/17/rs178844/26763475/[c/t]/agctctagatccccagagcaggggtcccacccgtgtccagcaaacaga gggaggaaaggg[c/t]attctgatccagcagttggtcaagcaatgtggaaatggagcccgctcccccttcacttta/t/ RAB11FIP4/RAB11 family interacting protein 4 (class II)/ 2254/15/rs2934442/55550085/[c/t]/tctgcaagtcactcctggtgttttacctgagctgcctagagtcactt gctgtgggttagg[c/t]tgtagaagacaaagatatgctggtttatctttagatatgcggattcatttgccatcaaat/t /CGNL1/cingulin-like 1/ 2255/8/rs13259602/4778638/[c/t]/caaataaatggatagatgaaaggaaggaaggaaggaaagataaatgga tggatggaagaa[c/t]ggatgaatgcacagatggtggtgaaaagatatactaacttataactacaactatccttat/t/ CSMD1/CUB and Sushi multiple domains 1/ 2256/10/rs10882406/95966922/[c/t]/cctactttgcaggtgtgtaaccttgggcaagctagtttactcactc 50 (178) JP 2010-88432 A 2010.4.22 tgaatctcaccttt[c/t]tcatctgtaaaatggcagcagtattagtaccagccttgtagagctgaaaggataggataa/ c/PLCE1/"phospholipase C, epsilon 1" 2257/6/rs316338/2782845/[t/c]/cttaaacatgatttaactcaagcagctaaatccttttttctcatcagctc cccaaaactt[c/t]taaagttgcatttcaaagttaaaaccaacattggcaggcgcggtggctcatgcctgtaat/t/SE RPINB1/"serpin peptidase inhibitor, clade B (ovalbumin), member 1" 2258/5/rs4404633/63885913/[c/a]/ctgcactatacaactgtttctcctttcaggtgccaggaacctcttcct cctctcatcctt[c/a]gtagtgacagcaccatacagccaacctcaaattccttggtgtttctgtttgccacccata/c/ RGS7BP/regulator of G-protein signaling 7 binding protein 2259/2/rs764487/207709513/[a/c]/gacctttccaggacttggtaagttctaaaaagcaaataaaatgaggta gtatgatgaaga[a/c]tgaatgggctgtttggcctagtttctctaggcaggtcaaagaaggattctctgagtaggt/a/ 10 KLF7/Kruppel-like factor 7 (ubiquitous) 2260/3/rs4681476/150201085/[a/g]/aacctgaatgcaagttgaggtttattttcttttcccctgtgactaat atatcttaagagt[a/g]cttgtatagttgaagagttaagtgcttaaaaattgtctattttgtctgtatgtgttagtt/a /GYG1/glycogenin 1 2261/5/rs17607156/178618938/[a/g]/cccaacgtccagtgactgcgggctcactctgtggcacttcccaagt ctttcattgtgcag[g/a]tatttgtggactgactagtgcactgtgggctgtatgaggtcagggctgtgcctgtctggt/ g/ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2" 2262/20/rs379863/42694108/[c/t]/ccgtgcccagcaccagcccgtcccctagaacaaattattttgctttct atttctcctctt[c/t]gattcttcttctccagcctccctcctcaacaaccatcaagaaggaacttctcaacacaga/t/ ADA/adenosine deaminase 20 2263/6/rs2814483/48112849/[a/c]/taaaagctttgataatatgctctctctctctcaaaatatcttacacta tactcactctct[a/c]gtcatgacgtgagataatacaatgcctacatgatgagatgaagtgaggtgaattgcacag/c/ C6orf138/chromosome 6 open reading frame 138 2264/6/rs332586/48118668/[t/c]/gtacagaatggaaatccaacagattacgtttgatacattagctggggac tagacccaaga[t/c]cacaaagattcatcagaaatctgagcagaccttgctttggctctttctttttggctacta/c/C 6orf138/chromosome 6 open reading frame 138 2265/6/rs6921573/167186435/[c/t]/ccaactgatggtgacagcaggaaatgcacctgccctgccccctcgcc cggatactttcta[t/c]tctgctatgaaaaacagagtaaaatttgagaggaaagggaaagtacccccgtagccacaa/t /RPS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2" 2266/9/rs10992158/93714748/[c/t]/ctttcttccaaagtcaaagcaaaaatctccatatttaaaagaatgtg 30 aagcttaagtgtt[t/c]tgggaaaaaaattaacaaacatgtaacaggaaaaatctggaatatttctgatttatcagc/t /ROR2/receptor tyrosine kinase-like orphan receptor 2 2267/15/rs3098198/48607496/[g/a]/ttagttcttacctctgatgaatcttcaatttgcagcaaattctaaac acagttctctttc[g/a]aaaccaacttttgaccccttaattaaccaataatagtttgattactaaaagaactaagtt/g /USP50/ubiquitin specific peptidase 50 2268/12/rs7958562/106261538/[g/a]/tggttttctcttttacaacagtccaaggcaggtaggcagtccaaag ctgggatggttatt[a/g]tattagtccattttcacaccactataaagaaatgcctgagactgagacatatataaagga/ a/BTBD11/BTB (POZ) domain containing 11 2269/1/rs7547496/26563068/[t/c]/acttcagaactagccagagagcgcacagtttccgccctttgctaacgc actgagatgcgc[t/c]ccctgggcgccccctgctgggcgatgcggatggtgaggccaatcgcatcggcggtcgcgc/c/ 40 ZNF683/zinc finger protein 683 2270/3/rs6778759/29931947/[t/g]/agagctaaattactgaagaccatcatgttttcctgtggggtttttcca tgccctgaatat[g/t]ttatacatgctttttgttggtgttttcttctctgttctatttgacattttaaagagcaga/g/ RBMS3/"RNA binding motif, single stranded interacting protein" 2271/14/rs1147465/68863377/[g/t]/cagggtgatgaatagagcagccatggctccaacctgtggggcccaac ccaaaggccagcc[g/t]cctactcatactcatactcccttcctgcgagaccccaggcctggtcagcatggggaatag/t /GALNTL1/UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltr ansferase-like 1 2272/15/rs488156/71412948/[g/a]/cttccagctacagccctgtagctagtggcaagctgttctgatactagt gaccgaagatga[g/a]tactttttgtccacagctcatcacctgcagtcacccccacctgtggcccccatcaagggc/g/ 50 (179) JP 2010-88432 A 2010.4.22 HCN4/hyperpolarization activated cyclic nucleotide-gated potassium channel 4 2273/17/rs4924839/18044632/[g/a]/gctggagatccctttgccaagtggtaacctaagctggtgtgtgctag gctctgtgctagt[g/a]cccggaatggggtttgtatgggttcctattctcttttgtcctttgggaaaaggcagacat/a /ALKBH5/"alkB, alkylation repair homolog 5 (E. coli)" 2274/17/rs1378602/18052593/[t/c]/atccaggaggaataccaagaatatgagaacctaggtcctggccaatt ctattcttcagcc[c/t]taacaggcaacaaaaccaaggaaaaatatatagaatcaaaaaaaacaaaaaacaaaaacc/c /ALKBH5/"alkB, alkylation repair homolog 5 (E. coli)" 2275/5/rs2950849/90430381/[g/a]/aagctctgtcagcacataccactcgctttgctctaagcacttagatga acatgcaggcca[a/g]actttgaaaattggttcctagttgttcatacaaaatgtgcatgtccctttgtactccgcc/g/ GPR98/G protein-coupled receptor 98 10 2276/15/rs12050614/47576705/[t/c]/ctcagaggggttgtatgacctgctcaaagacattcaagttctttat gtgcaagttgaata[c/t]attagagcagatgaaacattagggactatagtataggaaagcctccaaacaaaagcatac/ t/C15orf33/chromosome 15 open reading frame 33 2277/7/rs4215/99407330/[g/a]/agaccttccacccctgtggtctgttattcactgaccgttactgtcgttgta atactccac[a/g]atgtctttcagggtctccataaagatgtcctccctggccttctgaagttggctgtcctgc/a/AZG P1/alpha-2-glycoprotein 1 2278/7/rs4363136/102822491/[a/g]/gcatgtcactccccaaatctagatggggaatctgtttcccctccagc tatatttgggctg[a/g]cctcgtgatgtgcttcgagcaacagaatgtggtggaagtgatgctgtatgagtgccttaa/g /SLC26A5/"solute carrier family 26, member 5 (prestin)" 2279/9/rs2000069/106675690/[t/c]/tttagggaagcttctggctactcagagctgctctctttaggatataa 20 caacaacagagca[c/t]gagaaactggaattctggtcctattactgccccttgccagctgtgctttcttaggcaagt/c /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1" 2280/13/rs7997510/50921534/[a/g]/ctttcccgcaaacttttggtaagccttatagacaagaactaaagtgt tctctgggggcag[a/g]tatcaactgggaaaaggaaaatacaggtttaaattacaaatgtcctcagcctctccatga/g /INTS6/integrator complex subunit 6 2281/10/rs598672/30782394/[c/t]/tgtatcttatttaaagatgtaaaacagcactcatgtttaactcatctg tgaagcaaaaaa[c/t]gacccagaaaagcctttctttcctgactctaaatgagattctgaaaaatgcgttcgcggg/c/ MAP3K8/mitogen-activated protein kinase kinase kinase 8 2282/2/rs207873/216835554/[a/g]/ttatgaggttagaggattattggagtcagtgaatggggggtgatggtc ggagagtgggat[a/g]tttaaatccagattttggaggtggtgtggttactagcaattatgaatctaggatgtgact/a/ 30 4-Mar/membrane-associated ring finger (C3HC4) 4 2283/6/rs11965835/36066849/[t/c]/agagagtagatcttaaatgttctcacaacaaaaataataactgctgc tagggctgcaagg[c/t]gaaaacaattaaaaatgataattaggccaggcgtggtggctcacgcctgtaatcctagca/t /SLC26A8/"solute carrier family 26, member 8" 2284/12/rs10876078/37463672/[t/c]/ctcagctgatgcccacccacagagggagcatttaaactagtcttac tacagtcacacagt[c/t]ctagtgatgatagccaaagacaggcttgtgtcaccgcatcccaagcttcaggtggctcag/ c/CPNE8/copine VIII 2285/10/rs2447027/14043369/[c/t]/tctggtgtggtgatgagctcatacccttgagaatgaagaaaatttcc atctgaggctggg[t/c]ggtgaggcttccaaaataggccagctggttttcaaaagggccagtggtgggtatgacagt/t /FRMD4A/FERM domain containing 4A 40 2286/5/rs29437/65585071/[t/g]/gctcatgaagcttcttccttttggcaccatcctctgttccttctgacagg aaaaacttct[g/t]tcatgtcccaaatgggtgtggaagaataccacaaggaggattcagctctcatcatggtga/g/FL J46010/FLJ46010 protein 2287/4/rs7041/72837198/[g/t]/agaccttacatttaaatggtttttcagactggcagagcgactaaaagcaaa attgcctga[g/t]gccacacccacggaactggcaaagctggttaacaagcgctcagactttgcctccaactgc/t/GC/ group-specific component (vitamin D binding protein) 2288/18/rs2644267/32490024/[a/g]/ttagctgctggagtaggatgacaagctgagcatccaggcagctgctg acacaggcatgga[g/a]cctgtgtggatcaggctgcatcagggtctcgtcacggagagtgctaggtgtcgtgcgggg/g /FHOD3/formin homology 2 domain containing 3 2289/10/rs11193190/108808277/[c/t]/tatattattaacaaagaaattaccttgactataattttcttcgat 50 (180) JP 2010-88432 A 2010.4.22 gattcagaaggcact[t/c]caggctgtcttactatctcaggaagtaggaattcccagtgcataatgcctgagtttgaat /t/SORCS1/sortilin-related VPS10 domain containing receptor 1 2290/2/rs2195477/51189362/[c/t]/cacagtactccatttctctagcttcagtgattggtacaagttctggca tgtgattctaac[c/t]gacccaaaagaatccttcctctgaacttttctatgtggactgggaaagagcatagaatct/t/ LOC730100/hypothetical protein LOC730100 2291/10/rs9423685/3153973/[t/g]/gatttattatgcgattgttttaaatgcagtttttcattcattcgagtt tctcgaagctag[g/t]ttaaacaatttctttttttttctttttttttttttttttttttttttttctttttttgga/g/ PFKP/"phosphofructokinase, platelet" 2292/18/rs180732/6347138/[a/g]/caccacgtgactttatctgacttttgctgtatctcatccaaagcgttga tatcttatcaa[a/g]ttagctcccacctgaaaccttgtttcagtctgcttaagtctatcccccaaaattgtaatt/g/L 10 3MBTL4/l(3)mbt-like 4 (Drosophila) 2293/8/rs501344/103183749/[t/c]/agggcacaaaatgtttcctccctgtggaactcaaggggagctgcaggg tagtttctgcct[t/c]cgtctctgcgctaattgcttcacgtttgctttcctcgttgccgtatttgaaatgtgagct/c/ NCALD/neurocalcin delta 2294/8/rs685501/103182877/[a/g]/atgcatacagcaacacaatctggaaataattgcctgcacaagctaata ctgttaggactc[a/g]gctttctgccctggatccaatgcagccttcgtatatagagggctgctaattcaccactaa/g/ NCALD/neurocalcin delta 2295/2/rs6719934/79768660/[c/t]/aaagtgagagcatcttgtctgtgtcaacttcgatttgagaggagggaa aaaaagtttcct[c/t]tgaaaatttgagttggccctaaacaaaatttcagccaaaattcatgctacctgtgtgaac/t/ CTNNA2/"catenin (cadherin-associated protein), alpha 2" 20 2296/12/rs758533/4789171/[g/a]/tccgggagccgggtctcaggcaccgctgggggcgaagccacgcgtcttt tcgggcagcca[a/g]tttcacacgcgcctgtgtgcggttccgggcatcccagtaagctctagcacccgggcgcgg/a/K CNA6/"potassium voltage-gated channel, shaker-related subfamily, member 6" 2297/13/rs9518579/101279382/[t/c]/aaaggtcagggaaattcatttgtggtttctgcccctcggggtctgt aactgctgtgtttc[c/t]ggtgtttccaaattcaagtttttgctatttatccctgggctgggagatagatctaattgc/ c/FGF14/fibroblast growth factor 14 2298/19/rs705507/43302561/[g/a]/tagacatcttgtgggttctgtagctaggttcttcctctggaaggtttg tgccagagatct[g/a]tggatcttcatgctattaccttggaaagacaagagatacttattaaccttggacactgat/a/ SIPA1L3/signal-induced proliferation-associated 1 like 3 2299/1/rs10798301/172215955/[g/a]/tctcaaagtgctgagattacaggcatcagccactgtgcccacccta 30 caccaagcatttaa[a/g]aaacatatttcccaattctcactgtattacccattcaaggaattctatctttagaaatag/ g/RC3H1/ring finger and CCCH-type zinc finger domains 1 2300/20/rs4925207/59900667/[c/t]/tcgcttgctgtcatgtataagttggatcctgtgatgcacttaaagcc cgttggtgactca[c/t]agctgtccacagactgtccagacaccttatggagcacccaggcccctctgtcattcctca/c /CDH4/"cadherin 4, type 1, R-cadherin (retinal)" 2301/15/rs1713551/69096647/[a/g]/acttaatattgtaaagatgccaatttatcctaattaaattacaaatt tacttaattccca[a/g]tcacaaatcccaatatgatttctcaggaccctaaaacaagatacattttatatcttagaa/a /LRRC49/leucine rich repeat containing 49 2302/4/rs219481/109560129/[c/t]/gatctgctaagtgtcactggcaacatggtaagagttgatgatgtggtc caggatggatag[c/t]gtcttctcaaaattgtcttgcagctgctgcagattatctgtctgcttgtgcaccaggatg/c/ 40 LOC391681/similar to exocyst complex component 7 isoform a 2303/9/rs4269622/28231422/[t/g]/aggcaaccatcaaaaagatccaaacagtgtgcaagtcctgcagtggta accgaggtatca[g/t]ggttctgtcattaggactgactaggcggcaggtatgacccacagtgaggaaggaagggca/t/ LINGO2/leucine rich repeat and Ig domain containing 2 2304/18/rs4358044/57698758/[g/t]/gtcaccaggcttttccaagttccactgcctcccagataacgtgatta aagcactttaaac[g/t]gaaagcacccaagcgtctaataaacactatctactactatatttctactacagttatctc/g /RNF152/ring finger protein 152/ 2305/15/rs3784327/76189313/[g/a]/tggaggcactgcctcatctgaagcagaagcagaagcacagattcgtc ctgttacccagaa[g/a]agcacacagaggctctgcctggatgtgtagggctctgtccccagcagaagaagatgacag/a /CIB2/calcium and integrin binding family member 2/ 50 (181) JP 2010-88432 A 2010.4.22 2306/15/rs965355/57847116/[g/a]/atatatttaacttttacatataaataaatcataaatcaaattttaagt ttttcatcaact[a/g]atttgcctttgagactatctattcttatctacttatttttgtcatttgcgaaaatatact/a/ LOC100130107/hypothetical protein LOC100130107/ 2307/7/rs2385542/104626001/[g/a]/tttaccaggcaccccctactgcctctgaaaaccccacatgaaacaca aatcttcccacaa[a/g]aggaggtttggctgtgacacaggttttttttgctcaaactcatgaaacaagcatgtatga/a /SRPK2/SFRS protein kinase 2/ 2308/7/rs1859786/104592740/[t/c]/ctactccaggcacacaaagggctatctcagaggatccaacacccaca taaagaaaaagta[c/t]tcatgacactgaaggcatcatctcttctcttcatttttgctttcttctctgagctacagg/c /SRPK2/SFRS protein kinase 2/ 2309/7/rs2237606/104581077/[t/g]/tccttgaacctcaaattcatcttcaaaataaggggcttggttaaaat 10 ggtctcaaagctt[g/t]ctttctgtacatcaacatttgtgtcagataccatctattactggtcttcgcaacacaaat/g /SRPK2/SFRS protein kinase 2/ 2310/7/rs2240453/104483424/[t/c]/ttaaatgtgtcatgttgttgttatctctgactgcatgtgtgctttct gtctggaatactt[t/c]ctccatctctttgccttctctatttcatggacttgttaaattgccattctttaaaacttg/c /MLL5/myeloid/"lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophi la)" 2311/4/rs2132935/144735338/[g/a]/agaaaaaaatgtcagaactcaagcctctgaatacactaagatataag acatgagaggagg[g/a]tagtgtcacttggaaaaaatgtcatgaaattctttctagatgctctaggtattgagcatc/a /FREM3/FRAS1 related extracellular matrix 3/ 2312/1/rs1799704/165742495/[c/a]/atgttgccaaggcttgctgtctactcttcttatcactgaaggtagaa 20 ctaagtggcagca[a/c]ccctaacccctaccccagcctaatcacgatattgccacaggccacttctgactacaaagt/a /CD247/CD247 molecule/ 2313/13/rs7994324/112954498/[c/t]/cccctgagaggcatccggaaaacacgagcaggatccgggcgatggg aaaggctggtgcac[t/c]gaacgctgggaacttgaaaatgcagcaaccacaattttaaggatcagtagaaagtttgga/ t/CUL4A/cullin 4A/ 2314/15/rs965353/57847498/[c/t]/atatttaaatggcattgtcttaaactacattctacagagaattaatgt c[c/t]cataaaatggtagtaaattttcattaaaaatgaaaaaaaatcgatactaatgatatgatt/t/LOC10013010 7/hypothetical protein LOC100130107/ 2315/7/rs6971267/37109212/[a/g]/tccatgaaaatgagtgaaggaatacttatccataaagggtcgtaaaga ttaaatgggaaa[g/a]caaaatggaagtaaagatttccttagtgcctgaaacacctcaaacacttgatggagacaa/g/ 30 ELMO1/engulfment and cell motility 1/ 2316/3/rs831072/71510397/[t/c]/agtcattgctttgtccagggtctccatgctgtctacactgactgtccac tggtcacttag[t/c]agccatattggttgtcagatcaactataatcatatcccagagcttgtgttcaaggtatcc/c/F OXP1/forkhead box P1/ 2317/18/rs7243826/22407464/[a/c]/cgtgatgctgccctacttataaagagacaaaaagggcaagttgttta ttttgaattaata[c/a]gaacaataaaatgtttatgtttgggcacaactatgccggaagacgtgataaggtggtgag/a /KCTD1/potassium channel tetramerisation domain containing 1/ 2318/17/rs11079321/53102415/[a/g]/cccaccacaccaggagctgggtctagggctggaacttggtgggccc ctggcttgttccaa[a/g]tatgtgaactgagctcatctggaaaagattttgtaaacatttgctttctctgaatcggta/ g/MSI2/musashi homolog 2 (Drosophila)/ 40 2319/1/rs2820306/200190428/[g/a]/ccaggcactgtggttattataaatcactgagacactgtttgccctaa aggagctacgtgt[a/g]tttggtaacagcttcacagtaagtgacgaataagatagcattaatccacatttgacagca/a /TIMM17A/translocase of inner mitochondrial membrane 17 homolog A (yeast)/ 2320/7/rs740988/28389315/[g/a]/tttctctgcatcccatctttctcaccattaacatgtacacattatgcct aacacgaatcc[g/a]ccaatcccttgcagccactggcatgctcattggtctctgcctccagaccctcccacttgg/g/C REB5/cAMP responsive element binding protein 5 2321/16/rs2343524/6145210/[t/c]/attttaaaaaggaaaaagtagtccggagtgagtccttcccattgactg ctttggacatta[c/t]aatctgccatctcttcctctggggcatccaggagacaagccctaggagactgagacatgg/t/ A2BP1/ataxin 2-binding protein 1 2322/12/rs3847938/124428094/[c/t]/acttgagagtgctgtggtgaggaatacacaggttaatatgtgttaa 50 (182) JP 2010-88432 A 2010.4.22 tatgtgtaagtagc[c/t]cagaacagggcctggctcagggatctaattattattattttccatgttgttataattttt/ c/TMEM132B/transmembrane protein 132B 2323/8/rs6980953/1569246/[t/c]/aatatcactgcctaatattttactgcctaatatgttattatttctataa cacgatgaata[c/t]acatggcctagagaaacccataaaacacagcaagcaataaaagctcgaggcgccgcacat/t/D LGAP2/"discs, large (Drosophila) homolog-associated protein 2" 2324/1/rs522694/54805325/[c/t]/attggtggccttctttcatttaccacaacgtctcaaaatcctgtggatc ttaaataccca[c/t]atatgttagtgtctccaggtgtagcctcttctccagtgagctccaggcctgagttccttg/c/A COT11/acyl-CoA thioesterase 11 2325/20/rs6035543/20004402/[g/a]/agtgactatagcttagatcaaaattttttacaatactcataagcatt acttcatttggat[a/g]tctttatagttccccttaatgacattatttgcaggactatctgatgatactcatttggtt/a 10 /hCG_2019139/hCG2019139 2326/18/rs550672/8123688/[g/a]/accccctttcctaatattatgccaccctcctttctgaaatacaccaaac ggaaatgccca[a/g]tttccccaaaccctcaatatttcccttcccaaggcctttgctcctgctgcataggagctt/a/P TPRM/"protein tyrosine phosphatase, receptor type, M" 2327/18/rs7236448/6903534/[t/c]/tggttttaatgagacccaaatgactctctcttaacaattcaagcagta gacaaagttgct[c/t]acaaatacagaaaacatctttttgtctacttcgcaagtctcaaaacgtgataatatttaa/c/ ARHGAP28/Rho GTPase activating protein 28 2328/14/rs11159273/77079605/[c/t]/gtaatctctggtaaaggcttggcttggatttaagttaacagtttta gaggtagaaggcaa[t/c]acaataagacaatcagagttttacaaaacggttaatactaaacattttaacaactttata/ t/SPTLC2/"serine palmitoyltransferase, long chain base subunit 2" 20 2329/9/rs10964139/19432558/[g/a]/aggctctacagagcctccctcctgcctcgtacatgccaagccggccc tgtcctggcactt[a/g]cagtgactaacggccgggcacctccctctcggttgatgccctccatgcaggacatctcca/a /ASAH3L/N-acylsphingosine amidohydrolase 3-like 2330/5/rs202116/64101033/[a/c]/ttaagcaaagaatatatcaaactcaaaaatgtctgtttaaaaacctaag accccagaaat[c/a]ggctgcatgagttgggttaaagcattaaataggaccggaatgctggtaggtagagaaatc/c/S DCCAG10/serologically defined colon cancer antigen 10 2331/4/rs2973217/37108811/[g/t]/cagcaccaccccggatgacataaatggtaacaaatgtagtaatggaca gatccataggct[g/t]gagggaaaggcagcttactgcatttctattgcttctcagcatttctgacttgggtctgag/t/ KIAA1239/KIAA1239 2332/1/rs11581982/64077525/[t/c]/acatttaccttaaagaaatagatggttgattggtttaaagaaagaga 30 cagctgaattgga[c/t]ggggaagccagattttgaccatatttctaagaggagctgttctgtaatgttttggtaaaa/c /ROR1/receptor tyrosine kinase-like orphan receptor 1 2333/1/rs223192/18483603/[g/a]/aaacaaactcacaccccagagttgtgagaaatactaaaagaaacaaaca tatgtaaaagc[g/a]tcttgcaaaatgcaaaggcaagtggacactgctgttagtgtgaatttattgctcagcttc/a/I GSF21/immunoglobin superfamily 2334/1/rs4379644/178281357/[t/c]/aaaatgtgggaaaagtaccaaaagttattgagtagctattatgtctc tgaaactatctga[c/t]gttcatttaacctttactgacaccttcactgaaacttcatgtaaaccatcatctggatta/c /CEP350/centrosomal protein 350kDa 2335/17/rs4969266/76376141/[t/c]/ccattcttgtacatttttgctgagtaggtttagaatgatatctcgtg tagcctggatttg[c/t]gtttctctcatatcgcatgatgttgaacatttcctcacgttcagtggccatagttatgtc/c 40 /KIAA1303/raptor 2336/2/rs6719884/58890420/[c/a]/cttcctttataaatatatatatttagctaggacctctaagacaggctt gcttcttgaggg[a/c]aatgatatttaaactttggcttgaaggctgagttcttcagatgagtaaaagaaagaagag/c/ FLJ30838/hypothetical gene supported by AL832565 2337/3/rs6804610/2844944/[t/g]/taacaaatgatagctaatggttttaggtcctgagtctttgtttcttggc caccactgaga[g/t]agctgcattttgataccaatttcatgtcacctgagaagcgacttccctgagagatgcctt/t/C NTN4/contactin 4 2338/19/rs6509732/58394320/[c/t]/aatctattgataacatcaagtgaggatttggtgtattaatgaaggat atcataaaagata[c/t]ccatgagcagccagatgaagagatatgtatggtgaggtctgagaatgttctaagcacagg/c /ZNF818/zinc finger protein 818 50 (183) JP 2010-88432 A 2010.4.22 2339/1/rs10863899/209732841/[g/a]/aagccatgtgtgggccagcttgcacctaacagacattaggtagcac taaaacagatgcac[a/g]ctgccctgtgaggggcatgggaatactgtaatgggcatgaagctgcattataatagatct/ a/RD3/retinal degeneration 3 2340/19/rs2285957/3757837/[t/g]/ggttttggtgctgctaggagatttttcttataaacaaatttgcaaaca aggtaaccacag[g/t]tgagggctgggcaggcggagctgtcggccacggctgggcttctaggaccatggtcagtgg/t/ KIAA1086/KIAA1086 2341/20/rs6030267/40531103/[a/g]/tggacatgtctacagctctgaagaggtttcctaggggagctgggaag tttctcaactgcc[g/a]gggatagatgctcctttgtgaatacctttttgttttttttttctcctgtgattcaccaca/g /PTPRT/"protein tyrosine phosphatase, receptor type, T" 2342/20/rs10485485/5232380/[c/t]/ttctatgcatcttatggttggggtagggggtaggggaggaatgcttt 10 gggatatggtaga[t/c]gaagataagaggcatgaaggacagggaggaaacaaatcaaccctggaaatgaacgtgtac/t /PROKR2/prokineticin receptor 2 2343/9/rs7357690/22646227/[a/g]/tttgtgggattgtgcatctggggtacaataatttttaagtgtttagtt ctttgaacaatt[g/a]tgcagcatacatacagacctctctgcctccctctctcccgaatgcaatccactgtgggaa/g/ FLJ35282/similar to mariner transposase 2344/5/rs11959588/35240556/[t/c]/atttgtgagaatcaaaagattttttaaacaacctggaagaatcttca caaattccaaaga[c/t]tcaacccaccagccttacacatgacaatgctagcagtagaagaaagaccttaaattaccc/c /PRLR/prolactin receptor 2345/4/rs11732418/137983049/[a/g]/ctatctgttctacatttacagtcattttatcataatttaaaataag atgccatatcaatg[g/a]gcttgatcagagaatataaaaatggatgcaattaatgaagattcctgttcatcagatata/ 20 g/LOC729578/hypothetical protein LOC729578 2346/3/rs9850440/53261728/[c/t]/acagtatgtttccggaggggtaacggcggtgaggaaatcagactttgc ctaacaaagaac[t/c]aggagacacacttgacattccactcttttggagcaccctacatttgtaaatcttatttct/t/ TKT/transketolase (Wernicke-Korsakoff syndrome) 2347/5/rs4700720/179547251/[a/g]/acaaatttatacacctgtaagagtctagtattctgaacatataaata actcctataactt[a/g]aagaaaatacaaataacccaattttttaagaagcaggcaaaatacttgaatagacatttt/g /RASGEF1C/"RasGEF domain family, member 1C" 2348/13/rs9572817/71333512/[c/t]/aatgtggagttcagaaagtaaagtatcatcataaccatgttcacttt tgacaaaaataac[c/t]acgatattgtgagagactaactcttagaaaaacaacaggtttggaagagattatccaaat/t /DACH1/dachshund homolog 1 (Drosophila) 30 2349/2/rs13002663/144936633/[t/c]/agaataaagttgtgcagcaaatgagaaattatgatataactcaagt gctatggcatgaaa[c/t]cggcaaaatgagccatctaaacatttttcagaaccaaaaaattaaagaaaatggaaactg/ c/ZEB2/zinc finger E-box binding homeobox 2 2350/2/rs960537/124629987/[t/c]/tacgaggtgagggtggctggccacgcacattatctccagaggagcaaa ggcttgctctat[c/t]ccacttgtccagaagaggctcaactgcttgcccccagaatttgcaatagacttggtcatt/c/ CNTNAP5/contactin associated protein-like 5 2351/2/rs1881793/124634127/[c/t]/gctctcctgagtctccagcttagtgactgcagatactgggacttcca taatcatgtgaat[t/c]gatttcttataatttctctcctgcatgtataataagagagagtctgttcctctggtgtac/t /CNTNAP5/contactin associated protein-like 5 2352/13/rs341521/59297046/[g/a]/gagtaagaaagaagtgtagtggcctttttcagtactttaaaatcccat 40 cgggaaatgttc[a/g]tgtgctcaaaaataagtcacagaaataaaaatgtattctatatgagaacaggtgatattg/a/ DIAPH3/diaphanous homolog 3 (Drosophila) 2353/18/rs7228266/40874531/[a/g]/acctctctttatggattgagaaattagcctttgtgtttccacctttg ccggccatgcaca[a/g]atatttctctgaggccaaagacaggtggtcccccattttcctcccttgcactctttccct/a /SETBP1/SET binding protein 1 2354/1/rs6659412/180664824/[t/c]/tacattctaattttccctttttataaagataccagtcgcattggatt tggggccaaccta[t/c]ttcagtacgccttcatcttaacttagaaaattacatctcaacgatactttttccaaatag/t /LOC127671/similar to putative membrane protein Re9 2355/14/rs7149337/50778767/[g/t]/tcaggggagaggaactgtgacactttttcagtcatcatcatgagtaa cttgttttagatc[g/t]tgcctgtaaaatagtgttataagcaatatattaagcaatagtgatcgtgtgtgtatatgc/t 50 (184) JP 2010-88432 A 2010.4.22 /TXNDC1/thioredoxin domain containing 1 2356/14/rs7148018/74026906/[c/t]/acacactcttaagcatccaaaacagtttgagaaacactctcttccac tccaacccatttt[c/t]ggtgaatagggaaaaaagaaatcccgaacttcaatcaacaatctattgaaaatcagtgct/t /NPC2/Niemann-Pick disease 2357/19/rs8107385/43324592/[g/t]/tcctggaggaggcagggaaatgggaagtggggaagcccacaggtaga tgttagcaccacc[g/t]ttctagtcctggggttggctggtagcttcagggagtttgttttatgatgatgacaaatat/t /SIPA1L3/signal-induced proliferation-associated 1 like 3 2358/20/rs6034046/14748958/[t/c]/caaagatctggaggaacctcatcctttcattctaaaaggagtcgtgg atgtagatttaac[c/t]gttctggtatctgaaggtggtgggattaggaataatttttcttccttttttttttttttt/c /MACROD2/MACRO domain containing 2 10 2359/4/rs4444838/37533172/[a/c]/tatagtcaccgtattgtacaatagatctcttgaacttctcttctgtct agctgaaacttt[a/c]ggccctttgacaagcatctccccaaactcccctcccttatccccacccttccccagtcag/c/ PGM2/phosphoglucomutase 2 2360/6/rs1040285/109689879/[g/a]/tcgtgggggagataggcctgctggcattcaagtctgcagcagacgaa ggacagaaacaag[a/g]ccaagactctcacgtgctgctcttggagatgttttccaaacttctggaactcttgaccct/g /FLJ37396/hypothetical protein FLJ37396 2361/10/rs7069120/90091703/[a/g]/gattttttatattctctcaaaaagatagtttctactcaccacatatt ctaggtgctccct[a/g]agtactcccagtctacttggcaggaaagttgcagccatgtaactattaggttggtgcaaa/a /C10orf59/chromosome 10 open reading frame 59 2362/6/rs11962845/132439595/[g/a]/gaagtgatagtagtggaagtggtgtgaaatggctcatgtccatgta 20 acacatgtgattca[a/g]ttagaatttccttgttgtatttggtttctatggagagagattattttttattcctgtcac/ a/LOC100131774/hypothetical protein LOC100131774 2363/9/rs1322163/10177598/[g/a]/gaattccttccagttctaacttgcagtgagtatctgtaaggttactaa caccatatttct[a/g]aaataaagacagtaggtacatcgctctccaatactgaaacttttctcccttcagccgtga/a/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 2364/5/rs3733724/115807872/[t/c]/ttccattacaaaagccaaaaaaaaaaaaagtaaaaacaacaacaacc acctactcctaaa[c/t]aacagcaaaactaatggacttttggaacaaagggctctcacccaccctcagctaagtact/c /SEMA6A/"sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaph orin) 6A" 2365/8/rs7013593/125779150/[t/c]/gaagaaaatataaaatgcaatactataggccctgcaatggtttgcat 30 attaagttcttct[c/t]tacggttgtattttctcaagtttctataacagacacacataagctatggagtaatttttt/c /MTSS1/metastasis suppressor 1 2366/21/rs6518035/21324275/[a/c]/ttcttataattattcatggtattcaaatgtctaaaaattcctgctct gtagctgggggtg[a/c]aagacagcaacattgaaaagcacttgttatctggttttctttcctatttcttgaacattt/c /NCAM2/neural cell adhesion molecule 2 2367/7/rs2906294/147493833/[t/g]/aggaaagccatttgtaaaatgatgatgaggacgtgcttcttgcctgc aggttaatcccaa[g/t]gtgatcacaaatagctgcacgatgatgccaggcacaatttgatgtatgggaggcagcaag/g /CNTNAP2/contactin associated protein-like 2 2368/17/rs1136287/1620026/[t/c]/acaagctggcagcggctgtctccaacttcggctatgacctgtaccggg tgcgatccagca[c/t]gagccccacgaccaacgtgctcctgtctcctctcagtgtggccacggccctctcggccct/c/ 40 SERPINF1/"serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epit helium derived factor), member 1" 2369/4/rs7440527/7877724/[c/t]/tcatgttagagacttgttaaccctaaggggtaatacaaatattatcatt catattttcac[t/c]gtttattatagttctaagaatgcatttatatcatgatttcattctacccctttgaaaatt/t/A FAP1/actin filament associated protein 1 2370/4/rs2566144/38758939/[a/g]/tgtcatatagcattatttgagtagtgaagtggtaaagcattcacctca gcagaaaatttg[a/g]taatggtaatttattattcaaaggaaggaactagagcataaagcaatttgtcaagcttaa/g/ KLHL5/kelch-like 5 (Drosophila) 2371/6/rs7764938/144262097/[t/c]/ctgaagtggaagacagtagatttataaaccacagaactggagccagc aaacagcaccata[c/t]agtcgaaggtctcaggtacatacttacaatatagcataaaaactattagtttcatagacg/c 50 (185) JP 2010-88432 A 2010.4.22 /C6orf94/chromosome 6 open reading frame 94 2372/12/rs11057927/123996536/[a/g]/tgcgccactgcagtccagcctggtaacagagcgagactccgtctc aaacaaacaaaagca[g/a]caaaagagataaatgtccagaacgggcaaatccagagacagaaagtggattcgtggggct /g/DHX37/DEAH (Asp-Glu-Ala-His) box polypeptide 37 2373/17/rs2304921/72086421/[a/g]/atttgaagcattctttcaatccaaggcatcgaattcttggacaggaa aggtagagtggtc[a/g]actaccctgtggcagttttgagcaccctcaaattagtggggaggagggaagaagagcaaa/g /ST6GALNAC2/"ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgal actosaminide alpha-2,6-sialyltransferase 2" 2374/21/rs2836544/38884994/[a/c]/gaagccaaggaaggacattcagtaagatggaaagttcagtgtcgcaa ctgcagagagatt[c/a]atgtccaggagaaagtcattcaaccaaccatacgcattgagaacaggtcctggatttggc/c 10 /ERG/v-ets erythroblastosis virus E26 oncogene homolog (avian) 2375/3/rs1373163/64502361/[g/a]/gtgcgaacaatgtcattcattctataggcagataattcacatctcgga tcatcacaccct[a/g]ttttttgtgattggtgttttctaggtgagttaccccagaattgcaaggaggtaaaaagac/a/ ADAMTS9/"ADAM metallopeptidase with thrombospondin type 1 motif, 9" 2376/10/rs2243548/91000293/[a/g]/attgtggtaattcctttaattttttccctttcaatttactccttatt ctctagtaataat[a/g]gacttttgggaggttgcatttatgataaaaaatagcctggggctgtacaatccttcctat/g /LIPA/lipase A 2377/1/rs742071/18852461/[t/g]/tggttaaggacttaagaattgtcacttgtgtgtgtatattgttgttgtt gttgcaacggt[g/t]ctgtgtacgcacggttacagtggatcaaatttggggagttaggaagtggcgttggtttgt/g/P AX7/paired box 7 20 2378/2/rs1518805/141668414/[c/a]/gattttctaccaaccagaaatggcaaatttaaatgtctacaaggatc agaatgagaacat[a/c]aataggctaaatttattaatcaggactgtggcaaatctagatgatggccagaaagtatac/a /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors) 2379/5/rs17659044/150484609/[g/a]/agttctgaaataccagaacagagtttcccaaatttcagtcactcct aaaggactttcact[a/g]ttccaaattagcacacacactatgccatctcttaatggttttatgtaattcaacttcttt/ a/ANXA6/annexin A6 2380/17/rs4790921/61394976/[g/a]/ttctgtcacatgataaatattacatttatatttgataaatagaaaat ttgcctgcttgaa[a/g]tttgatctatttgtgcatagtgatgaatgtaagtgagaatattttccagttactttgaaa/a /CCDC46/coiled-coil domain containing 46 2381/21/rs2834380/34413370/[a/g]/ttgggcaaaagaggttctctacaatgaagaatatttgatcaaacagt 30 tcctgtggaatca[a/g]tttcatagttgggctttgcttatgtcattaggcaaggctggcacttcacatatttttatg/g /MRPS6/mitochondrial ribosomal protein S6 2382/6/rs9379638/10744123/[g/a]/ccagtctggcttcctctgacctcccaatctggacattgtctctatggg cctgttgtctgc[g/a]tttatcttacctggaaactctcttccttgttatgatgttgaatcttacattccatagaat/a/ GCNT6/glucosaminyl (N-acetyl) transferase 6 2383/9/rs4740427/133141684/[t/g]/gtttaatgaataattatgcggttctgacatccagcccttctgtgcct cacacgcggggac[g/t]gcagctcgcagactctccctgaagtcttcggaggaagcaggcgagcgccggcagactcat/t /FAM78A/"family with sequence similarity 78, member A" 2384/9/rs10793992/133139159/[a/g]/agagcagtaaagggacttgcctagggccacatcctggagagtggca gaacctggcctccc[g/a]cccagatctgcctaagaaggcatgaggctcttccaaccaggaagccaggactgcgacagg/ 40 a/FAM78A/"family with sequence similarity 78, member A" 2385/4/rs1355161/126487591/[g/a]/tttagacctttgtgaaagtgttaccctctcctttaaataagggctat actgtggtaagag[a/g]aatatttaagatataattcagtgactctaggaatgggagcatttacacttcttgaaagaa/g /FAT4/FAT tumor suppressor homolog 4 (Drosophila) 2386/4/rs2137871/6257055/[c/t]/caagggcattttggggatgtagctgaagggggattgagttggggatgcc ttggtttgggt[c/t]tagtggggtgtgtttatgtaggtctgagccagtctgtgtgggtcgagttgttgctccctg/c/L OC285484/hypothetical protein LOC285484 2387/16/rs2880647/6103801/[a/c]/gaatgcctaacatgtaacatacactctagaaatgtttgttgtcttgaa ttgatttgaagg[a/c]gtcagacaggccgtggtctctgtgtctttttacatctattattccactgccaggccgttc/a/ A2BP1/ataxin 2-binding protein 1 50 (186) JP 2010-88432 A 2010.4.22 2388/22/rs8138156/45233986/[g/a]/tgcaaagcccctccggggccactgcataccacccatcacactgcccc tttcaaccagcac[a/g]gaaggcgcctttcacaaaatgctgttaaacaaatgatgcaagaggaaggatctaagctgg/g /CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Droso phila)" 2389/15/rs8039451/34795656/[t/g]/aagggaatgtcaatgaattatagtttctctggctagaaagacatcta aatgattactctt[t/g]tcaagcatatgtaagatttttacaagaggggtatattgaccagtttcacaaatccagggg/t /C15orf41/chromosome 15 open reading frame 41 2390/6/rs7764197/10721443/[t/c]/aatgagaacgtcaagtcaatataaataaagcttgcatttcaaagaatc atgtttaacaaa[c/t]gcagttatttgactaagaaaggctgagccccaagaaaaacattcctggttactctgtaaa/c/ GCNT2/glucosaminyl (N-acetyl) transferase 2 10 2391/15/rs4480740/47543134/[a/g]/tgcataagttcttaatggtctagccctgcctatatttcttatttctt ttcctggaagttc[g/a]ctgtgtataagttgcaagcacaccaagttaacccccaaatgccacagtgttttatgcttc/a /FGF7/fibroblast growth factor 7 (keratinocyte growth factor) 2392/9/rs10814287/35850483/[c/t]/tatcaggtgctggggctatagcagtaaggaaagtaagtggacaaaag gattccacacctg[c/t]cacaggcgctgccccactccctgagtcaggtgagatgagctccggaaggcaggtgggtaa/c /LOC92973/hypothetical protein LOC92973 2393/6/rs10949428/17626454/[c/t]/aaatatatttcctgattttttatcttattcttccaaggtttgggcag ctattaaaaagta[c/t]attataacaattatatttttgaattttaaaatcaaatttcttttaaattattaaaaacga/c /CAP2/"CAP, adenylate cyclase-associated protein, 2 (yeast)" 2394/1/rs10924523/244386523/[t/g]/tggttccttcaataaacattaaaagcctgttatttgtgaggcacta 20 tgccaaccattagg[g/t]atataaaaccaaataggactcagtctctgcccacaggagcttaagagtctagtggaggaa/ g/SMYD3/SET and MYND domain containing 3 2395/5/rs411356/112200118/[c/t]/gacatgaaagagcaacagcttgtttaacgcaggcaaactgaagattaa tgacagcatatt[t/c]agctttagtgggctttaaaactgaatggcaagggtacataatgagctttaacatggtcgt/t/ APC/adenomatosis polyposis coli 2396/5/rs108042/141307146/[t/c]/ctgaggctataaggttggatggaactcttggtgttatagaatcaggcc tttccttttaca[c/t]gggtcagagagcttcagaaggagtgaagcttggaatgagaaaatcactggggcgtatgag/c/ PCDH12/protocadherin 12 2397/5/rs164074/141315468/[c/t]/gagggtcatgtttgtcaccagtgtggaccacctgagggactcagcccg caagcctggggc[c/t]ttgagcatgtcgatgctgacggtgatctgcctggctgtactgctgggcatcttcgggttg/t/ 30 PCDH12/protocadherin 12 2398/5/rs164075/141316448/[c/a]/gaagctcttcccaaggacagttttattgctcttgtcatggcagatgac ttggattcagga[a/c]acaatggtttggtccactgctggctgagccaagagctgggccacttcaggctgaaaagaa/a/ PCDH12/protocadherin 12 2399/6/rs9476005/57437845/[t/c]/ttggcaactatgtctttatagttgggattattgtaggaaaaagtcagg agcttgctgtaa[c/t]gtttgctactctgatcattgtaacacagtgtaacttcatgtaggtctaccactacagtaa/c/ PRIM2/"primase, DNA, polypeptide 2 (58kDa)" 2400/10/rs1572430/86189487/[g/a]/tgttttgaaaagaaacttttttgagctaaggaacaaaagagtggaga atcctttttggat[a/g]tgagattgttaacttctcttgaggcagaaataaattatatgattgaattatccagacatt/a /KIAA1128/KIAA1128/ 40 2401/18/rs9952185/59590623/[g/a]/aatataggtagaggttttaaagctcccatttacaaacccaacaataa ttttaaaggataa[a/g]aaaatagaggcttgtaggaaaattagatacatcatttatatttaactttgccactgaaac/a /SERPINB7/"serpin peptidase inhibitor, clade B (ovalbumin), member 7"/ 2402/9/rs10815567/723049/[g/a]/ttgatacaggtgtatcattattacaggatcattgtgtggatgaggcctc agccaaagatc[a/g]catatactgtaaagatgatgcatatcacttacatgtttgtattttgttacacattgaatg/g/K ANK1/KN motif and ankyrin repeat domains 1/ 2403/22/rs2072815/31111993/[t/g]/ttgtaaaggatgtctgtgattctttctaactggtctttgtccttgac agagaaagaacag[t/g]ggtcccttgggtcctgaaggaggggccccaggctcactcaggtatctgtagaggttctgg/t /C22orf28/chromosome 22 open reading frame 28/ 2404/7/rs6957462/77917611/[a/g]/aggatatattcttttgaattatttataaccttcacacaccctcagggc 50 (187) JP 2010-88432 A 2010.4.22 agaataaagggg[a/g]aagaaatgtcttgttagaaatataaaagatgggaagttattcatatcttgaaattgcccc/g/ MAGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2"/ 2405/12/rs2286050/119092414/[a/g]/accagcctgtgagtcagccactgacaactttaagagcaacaaggct gcggcaaccccttc[a/g]gtgatggtgggaacctgagtgctttgggaggctgccttctccactgtctggatgagcaag/ g/GCN1L1/GCN1 general control of amino-acid synthesis 1-like 1 (yeast)/ 2406/12/rs1151824/119162764/[a/g]/aaaacagcaatctctctccctggctttgaagccattcccaagttca aagggtcaccaagc[a/g]gatgcatctggaggcccctgcattcgtggtgtgggaagctcagtgcacaagccaacagga/ g/PXN/paxillin/ 2407/12/rs1151832/119179524/[a/g]/cagagcttcactctgcctatttgaaagcagcatgatgtgtgtttta tgggggagggggtg[a/g]tgctgggaggaagctttatgtaattcttggctggagctcaggtaattgttttaatgaaat/ 10 g/PXN/paxillin/ 2408/18/rs656617/38692665/[a/g]/acaagaacagaaagtagattcgtggttgccacagcctcagggaccaga taatggggaatt[g/a]gaatcaacttcaaatgtctatgaagtttcttttgaatgcgataatgatgttctaaaatta/g/ RIT2/Ras-like without CAAX 2/ 2409/3/rs9847121/54998861/[t/c]/agttgtgagctgcagccatgatttttgttgtcgatctttgttctgtct tgaatttgcttt[c/t]cacttagcaccaggtattgcttcatctacatttacacgtctccctacaggcttcctatga/c/ CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 2410/3/rs2291977/56949779/[g/a]/atataactagggttcctttattcctgagatgactgttttctaaagata agtatttaacag[g/a]tgcttttttttttaaatgtgagctgccccctcataaaggcaaaaccgaccatacctgggt/a/ LOC100128209/similar to hCG1799667/ 20 2411/3/rs3890747/56961527/[c/a]/ggatcttgggcagagaactcacttacacc[a/c]tgccctaacttcta atccacagaactccaagctagtgaacaactgctgtttaagctgcta/a/LOC100128209/similar to hCG1799 667/ 2412/3/rs4626067/56968071/[t/c]/agtcactgctttcaaatgcaggtttatcaaaaagagagatgcctcaag aaatggcccaaa[t/c]aaggtggatggagttttcaacagctctgcaatcttcagcagccaaattcaccccaaactc/c/ LOC100128209/similar to hCG1799667/ 2413/4/rs1265327/75313925/[a/c]/aaccagacaataggaataaagtattgccagaatgaccatatcatgcat tgtgtgtgggaa[a/c]taaacaaatacaaatagcagtgggtatttaaaggaaatagtgatctaatggcagaggtag/c/ MTHFD2L/methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like/ 2414/6/rs7746854/151970035/[t/c]/gtggcatcagtagagcaggcatttgagacagaaaaatatcccctact 30 aagtgtgggtcta[c/t]gggggttgaccttggagagaaatgtattttcagtctatattttttaattgaggaatttaa/c /C6orf97/chromosome 6 open reading frame 97/ 2415/8/rs10957146/61657532/[a/g]/agagagggtctaattgttattttccacataggagaagttattttcat tgaatctcagcac[g/a]ttaggatttacagatgtccactcagctatgtgggatggagtactgattattttacgcata/g /RAB2A/"RAB2A, member RAS oncogene family"/ 2416/8/rs603239/61684483/[t/c]/catgtcttccttctgccaccagccaccacacacaacatctgaattgata gacttcttctt[c/t]tccttattcctgtgttgtcctgggcatgaattcaccttagtatgatatcattgcacttgt/c/R AB2A/"RAB2A, member RAS oncogene family"/ 2417/7/rs697404/90516805/[a/g]/ttacaggtatgaaccactgtgcctgaccacaatttttttaaagaccaat ttctgttatag[a/g]tgtatgtacaaattcatatatgtgtatctgtgtaagaaaaaccagtttgggttttcaaat/g/P 40 FTK1/PFTAIRE protein kinase 1/ 2418/6/rs732394/36377062/[c/a]/cctgatacctcccctgcctaa[a/c]agtcatgctacaataatgcttgc catgaaaactaaggatcctagctgctgcctacagccc/a/PNPLA1/patatin-like phospholipase domain containing 1/ 2419/1/rs2801328/72188872/[a/g]/agttctctaccttagccattaatctctcacgtgaagctgtcaaaatct tttatgaaaatc[a/g]aaacctactatatccacttttcttatctttcacagtgcattattttcaagcagccaagca/a/ NEGR1/neuronal growth regulator 1/ 2420/1/rs1016126/72208991/[a/g]/cctgggcaacagagcgagactctgtctcaaagaaaaaaaaaatcactt aacttaaataat[a/g]ctgctctatgtcacatgaccttgggcattcttatatgtaaaaaagagaacatatactcag/a/ NEGR1/neuronal growth regulator 1/ 50 (188) JP 2010-88432 A 2010.4.22 2421/2/rs3792017/43870915/[t/g]/accagttcccaggaacactaagaaatgtcacaattttccacatatttg gccaacatgtgg[t/g]agttactgtcaggaaaacatcactcaagcgttttgaggttttcctctaagttctatttct/g/ DYNC2LI1/"dynein, cytoplasmic 2, light intermediate chain 1"/ 2422/18/rs8086848/54212303/[a/g]/cagcccatgcatcttccacgtgaggacgctgaagccctgtgaggaca atgagctccttaa[a/g]gtcacccagctcattagtgcagagcaaagccaggtccgtgtgtcctgacctctgaaatga/g /NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" / 2423/15/rs6496696/88930112/[c/t]/tgcctcagtttgttagacctgggtggggtgtgatgcagaactggagg ggttcctttctaa[c/t]tgctgtcctctggggttcttatccatttttgttatttaggggctttctttgctttctggc/t /CRTC3/CREB regulated transcription coactivator 3/ 10 2424/9/rs3887368/9016457/[c/t]/ccttgctgtgtcacatttagacaaagaaagacccagtttcttaaactgt ctaacagataa[c/t]aggcttgatctttattgtcttcctcattattatcatggtagctctctgttaccttactat/t/P TPRD/"protein tyrosine phosphatase, receptor type, D"/ 2425/2/rs3829746/179135782/[a/g]/aaaacagcttttgttaacgtcagagttcttgactcaccaagtgcccc tgtgaatttgacc[a/g]taagagaagtgaagaaagactcagtgacgttgtcctgggaaccaccacttattgatggtg/g /TTN/titin/ 2426/2/rs1947132/223253426/[c/a]/aaaacaagagaaaggtatttccctgtatgtaacactttttaaaagca gtgtagaataaac[a/c]cacatatgaagaaaactaggctgcaaaattctgcaaaggggtctgatgagatttgtcttt/a /MOGAT1/monoacylglycerol O-acyltransferase 1/ 2427/1/rs262688/2103425/[c/a]/cggaatcgtggaaaaaaccctcataggcttttgggaacttacaaagaaat 20 gcccacatcc[c/a]ttctactaacatggcatctactaacgtggcatctactaggatgccacaaaacagacaaat/a/PR KCZ/"protein kinase C, zeta"/ 2428/2/rs2192983/51405129/[g/a]/tagtacattcagagattactaacaaacaatgctatacctaacacactg tcctgatgtcct[g/a]agacgaatcagcaatctcctttaaagtagtttaataaaagggattttacgaaaaaggaat/a/ LOC730100/hypothetical protein LOC730100/ 2429/3/rs6445691/54549574/[a/g]/tatttttcagaaataaaataatcattttcatctgctaatgttgtctca tgttaaggtaac[g/a]tgggaaatcgtcagacaggactcacaacccagtcattgttccatagtatgcattggtcgg/g/ CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 2430/12/rs1523118/37515966/[t/c]/gtacaaaataatccagtgacccatgaatacgtctgaaacaaaaagtt tagtggtgccttc[c/t]gcaaccaaccaagtggataaatgtattttggattgccttgtctgtatgaaaatttagtat/c 30 /CPNE8/copine VIII/ 2431/12/rs1403521/37518274/[a/g]/ccagttattacgccctttgaagagtagtttgaactaagaaacacaga aactatattcagg[a/g]agagtggtacttggaagtctatgtccagtcagaagtggtgaggtcatttccctaaacaga/g /CPNE8/copine VIII/ 2432/2/rs2364722/177833033/[a/g]/atatttttgctttcatttacagaaaacataccattagcaattgaata aatcttggcctat[a/g]ccttaaagcccttttaataaatgtttgttggcgcttatttaaaagcaggtagcagtgaaa/g /NFE2L2/nuclear factor (erythroid-derived 2)-like 2 2433/17/rs9900506/76236971/[g/a]/gagtgctcacactgctaggtgtggtgggaggcgcctagtcaggcagc cgggttggctttg[g/a]ggagcactgcatggatggcttctaagatccacttgtcttctttcccctgggatgattaga/a /KIAA1303/raptor 40 2434/10/rs4750895/128727058/[g/a]/aggtcctgggagcactcagcttctggaattctttactctgtaattg tttgtggttctgat[g/a]ttttctgcagtattaggctcttctctgctctcagataccccacaatttgctggggcaact/ g/DOCK1/dedicator of cytokinesis 1 2435/16/rs10492852/11729209/[a/g]/catgataaaagacatgttttcttcctcttaaggccttaattgggaa aactcaattcttca[g/a]agcagtagttcttaatgggggaattttgccccctgaggggtatttggcaaggtctgcaga/ a/TXNDC11/thioredoxin domain containing 11 2436/16/rs3112612/51192665/[c/t]/taatcttccatgggatggagactgagtctcctttttagcatacaagg gccactctgatta[t/c]gtctaataaccaaatcatccatgagtagcctggtatagtgctcagtcagccagggtggtt/c /LOC643714/hypothetical protein LOC643714 2437/3/rs755661/25447044/[c/t]/aaaagttattagacctaatagagtttttacatgtagacattcttccttt 50 (189) JP 2010-88432 A 2010.4.22 tgtaattaacc[c/t]tccaaagatgcctattaagttgtaagagtagggggaaaagctttgtttgttcttggacaa/t/R ARB/"retinoic acid receptor, beta" 2438/6/rs3799859/46875604/[c/t]/taggagcagcctagcagcccaacaagactaagcaaccctgtcctggct tcccttcttcac[c/t]ctaatcttgttcatctgtctaagcaggaggggccttgcagacattgagtcatcatggctg/c/ MEP1A/"meprin A, alpha (PABA peptide hydrolase)" 2439/11/rs4930561/67688337/[g/a]/ttttcttccaactactcagaacatttttttatacatgtgttcaaaga aagcagttcctct[a/g]tcagctgctaaattctaaacgaaccacatgataaagatgagcagccacacagaaaaagca/g /SUV420H1/suppressor of variegation 4-20 homolog 1 (Drosophila) 2440/18/rs421436/38180576/[g/t]/tgtgaatattaaacaatggcattattaaaggctatccagtgctagctc ctaatatggaag[g/t]tattgagaagaatgtgtcattctatgtctgggaaaacaccaaagcaaaatctggaagcca/g/ 10 LOC284260/hypothetical gene supported by BC011527; BC021928; BC011527; BC021928 2441/19/rs350844/4128051/[a/g]/ataccctctgggtctctgggacatcggattcgacccccaaccccctctg gcagagccccc[g/a]cccctgcacccaggtggcactcacgtcttacacttggcacattcttccacaaacatgttc/a/S IRT6/sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevis iae) 2442/2/rs3814026/112358137/[c/t]/ggtccttcacagtgactcttgggccgcagcagcttctcattccctct ccctcccctattc[c/t]ggaggaagaacgggcaacagcagcgggctcgagtgctaatggcaggaaggcgtgcgagac/c /ANAPC1/anaphase promoting complex subunit 1 2443/2/rs7567632/51051888/[c/t]/tagtgcatagtagacagctaataaacatctgcagaattagtaacataa acataatgcttg[t/c]tagtgtcaagtggctgaaattcgatgattccaatttctgtgtttaaaacaataacaggcc/c/ 20 NRXN1/neurexin 1 2444/6/rs2153134/123852007/[c/t]/acatatcctaccaatatctcaaggtctatttcaattgttatgtcttc cataccatcttct[t/c]tggtctttcacactacgagtactattttttttgcaataaatattcataataaaagagaaa/c /TRDN/triadin 2445/7/rs3801263/97802952/[c/t]/gcatctgccggagaggagtcccagcgggggagctggcagcagttacca cccctgtgccac[c/t]gctgcctgcctcagttataaatttctggtgaggcaaggatgtgagaatcggatatagtta/c/ BAIAP2L1/BAI1-associated protein 2-like 1 2446/7/rs6945554/97810882/[c/t]/aggacttgagtatcccatgctactgtggttgttaggattatgtcgtta atgcaccttaaa[t/c]ccagacacttagctagctggtagtaaagaagtgctttttctttggagaaaaggataccaa/c/ BAIAP2L1/BAI1-associated protein 2-like 1 30 2447/7/rs6961129/97813478/[g/t]/tgcagatttcagaaaagaactaaataggacttccagtaacgaaagaca ggcactaaacaa[t/g]tcaatggaaccagcagttaggaaataaaaatttaaaaataccatttacaataggacaaaa/g/ BAIAP2L1/BAI1-associated protein 2-like 1 2448/10/rs6481514/28560804/[t/c]/ttaatatcaatctttcacagactcttccacagaagaggaaaggctcc tcccaatacacta[c/t]acgagaccagcatgactttttgaaattcggtaaagaatgaaaaagtgaaattacaactga/t /MPP7/"membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)" 2449/13/rs1327651/49995000/[c/t]/cttcatccctgaagtgcaggccagtcctacctccttcacaatgacgt gctgacatcatgg[c/t]gcaaatttgcaaacattttttgccttattaagaaaattattcaaacctagaaaaatgcaa/t /LOC730194/hypothetical protein LOC730194 2450/7/rs2240466/72494205/[t/c]/gaagggacaaagagggccataaccctcccttctgagagtttccaggag 40 gagtccgagggt[c/t]tagcttttctggtgaagccagttcctgttcctgccttctttcctaagggcctgctcgctc/t/ BAZ1B/"bromodomain adjacent to zinc finger domain, 1B" 2451/7/rs714052/72502805/[c/t]/tacagaaaacaaaattagttaatccttgtaactattttagttagtttag ttttaaatcct[c/t]tgattggctcagaactttagtcatctgtgaagtaagatatgtgctttcagcaggaggcag/c/B AZ1B/"bromodomain adjacent to zinc finger domain, 1B" 2452/21/rs2244084/40198919/[g/a]/gctagggcaatgaaaccctgagctgcctaaaggtcagaatccaccat agtgagagatagc[a/g]agtgctgctgtgaataccagaggcacatgggtggtggcgccttcaaggtaaaaactcaaa/a /PCP4/Purkinje cell protein 4 2453/11/rs541022/71460704/[g/a]/aggcactcattactttaggtatctgctcactacctaaggaaactgggc atttggaggtca[g/a]caatcagacagagtccactttgctgcagctcatgaggggtatagtaggaaattcttaggg/a/ 50 (190) JP 2010-88432 A 2010.4.22 NUMA1/nuclear mitotic apparatus protein 1 2454/8/rs768420/99171579/[t/c]/atgtttcggaaaagttttgctgacaaactgagcattaatagaatgcctc tttcccaggca[c/t]agaagcctttttggtttggtcaaacgaacttcaaccacctgaaagtgacttcagggactg/c/C 8orf47/chromosome 8 open reading frame 47 2455/7/rs6968634/131518382/[g/a]/ccaatcaaaggagcatcttcgagaagaatcctgctatctaaaacagg ctttagcaagtta[a/g]ttagctagaagttgatgagtaaagaatccttgacacacacacccacattcatttccaccc/a /PLXNA4/plexin A4 2456/4/rs7672861/142385191/[c/t]/gcaggtccttagcagatttgcaaagtttgaaaatgctgagtatcatc tggtttagttatc[c/t]acctaattcaggggtcttctgtatattgctgactcagcttattcaaactgttcatatgct/t /LOC729407/hypothetical protein LOC729407 10 2457/2/rs1835815/43884153/[a/g]/agacataacctcctccttcccgacccctcccctggtctccccatccat agttctatccct[a/g]ccctctgaccaccactaatctgcctccatttctaaaatgtttttcatttcaaaatttttt/g/ DYNC2LI1/"dynein, cytoplasmic 2, light intermediate chain 1" 2458/1/rs7552738/231871795/[g/a]/cttacaatgtggatcattttttaaaaagcaatctacatagaattagt ttatgttttgagc[a/g]tcaagaacctgagtatctaacaaatgaatattccaaagatatattagatgtgggcaggat/a /KCNK1/"potassium channel, subfamily K, member 1" 2459/14/rs2144594/98933050/[g/a]/aaaatattaaatagtctgtaaagcttagtgttaatttctaaaaggca atagcattgtagt[a/g]cttgagtttccgactctagaagccccagagccttctagaactttgatgaccaatttgtcc/a /SETD3/SET domain containing 3 2460/1/rs12746270/45001167/[t/c]/tgcaggttggcacacataggctttctgacatcacactagccagagct 20 agtctctcctcca[c/t]gctcctgatagaggatttgaagggtgatccatatgcagggatcttgtcttgtgttttggt/c /KIF2C/kinesin family member 2C 2461/1/rs4342887/44997585/[c/a]/gtgcaagtggtggggctgcaggagcatctggttaactctgctgatgat gtcatcaagatg[c/a]tcgacatgggcagcgcctgcaggtgagagtcctggtgaggggaaggagcgaccttctcat/a/ KIF2C/kinesin family member 2C 2462/6/rs9384825/112774886/[t/c]/aaggacatgaaaactgttgtagatcctgtccgctcatgattctatca ggaataggaacac[c/t]aatgattacattagccacgaggtgattaggtttcagcagtgcatttctgtatttgatctc/t /RFPL4B/ret finger protein-like 4B 2463/17/rs11649949/3619690/[g/a]/ctcgcagccacaggggccctgttacaccctgagctgggtacagccca gcaacccttgtcc[a/g]tctcctgcctttatttattgctttagtatgtttttcgttgtttgtttgctttttgagatg/g 30 /ITGAE/"integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; al pha polypeptide)" 2464/17/rs2028627/52875090/[c/t]/gggttgctgacgagaccctggaatgcccagagaacagaggggtggga gcgagggaggcgg[c/t]gctggcctggggccatcttactcttcctttcttcctgacaggtgtgtagaatggcatctc/c /MSI2/musashi homolog 2 (Drosophila)/ 2465/21/rs1984020/37105929/[a/c]/agacctctttcccatgtaagacacccatgaaacaatgctctggtcat aattagtctctaa[a/c]ctttcaaaatgcctgcttcagtgacctcacctgctattgaacacgatgcctgcagatggt/a /HLCS/holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP -hydrolysing)) ligase)/ 2466/1/rs303386/99361967/[t/c]/gcttagggaccatgaactaataagttcattaccgcacattatcttaagc 40 acatgctatca[c/t]gctatttggtaactatgatactatttcaagttttaagggaaaattgctacaggggttact/c/L OC100129620/similar to hCG2028334/ 2467/1/rs2269340/109973759/[c/t]/caccttgggccagggccactagacctctgacccacctgttgcctgga ctggatgggttct[c/t]tctctgcccttggagctacatctgtcacccctcacagccagtaatctacccctgtccccc/t /AMPD2/adenosine monophosphate deaminase 2 (isoform L)/ 2468/20/rs2273534/55718946/[c/t]/tggagaaagggggaggaagcccccaagatggatcacccattgcctgg tttcgcaggagac[t/c]gtccgccttcagttctccagcagctcggggatcatggcccactgaacccccaagcgcttt/t /TMEPAI/transmembrane/ 2469/1/rs437021/61510858/[a/g]/agaccttaaagatgttcaaaatttagataagttttagtttctgagggtt tgggaagataa[a/g]tactctgcagaagaggccaaggaattcatttttctacatctataaggttgtaatagagaa/a/N 50 (191) JP 2010-88432 A 2010.4.22 FIA/nuclear factor I/A 2470/11/rs2449095/107029795/[g/a]/cttttgcactatcattaatgatcaaacccctccttcctgaaacatt tagtgaggtaacta[a/g]atgtcgcctcactctctcctgattccctactgcattttgtttggttttacctagtggtgt/ g/ELMOD1/ELMO/CED-12 domain containing 1 2471/19/rs2607272/13773062/[c/t]/ctagggacaagggtagaggttgagacatggtggtgaaggtgccagac ctcaggcttcagg[t/c]ccagatggggttgggttcgggattatgagctgaaggtggaaagtgctcctagagccctag/c /ZSWIM4/"zinc finger, SWIM-type containing 4"/ 2472/22/rs2239844/44305776/[g/a]/ctgatagtgacaagaagagagaatgttgggagtttcttttaagataa gatgggtgtttgg[a/g]taaatgtctgacttggtctttttcccccttagataagatcattgaggttgaggaggaaca/g /FBLN1/fibulin 1/ 10 2473/22/rs713900/25228242/[a/g]/ctaatgatactccttgaccccattcgccctcttacaaataatgaggtt cagaaggcaggt[a/g]caccagatgggagggagaaacaaaaataaagataaacgaaacaacatttattgagcatct/a/ TFIP11/tuftelin interacting protein 11/ 2474/1/rs11801737/214559014/[g/a]/agcaaatgagagagactaataccgactgactagtcaacagaaagca agagaagctcagaa[a/g]agaacatatcatatgaaggtattagccaaactgtagcttgcaaatactagacatattcag/ g/USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 2475/1/rs7544722/72179997/[c/t]/aaaatatgttctggtgatatctaagtgagaactgcacttcagcaggta acagttcaatac[c/t]gttcagtatacaatagtaatatgttaacattactatgcaccagatacattttaagcatgt/c/ NEGR1/neuronal growth regulator 1/ 2476/20/rs6043448/15620226/[a/g]/actagaacattagatggtgacaagagaaaatatagcagtcctgtggc 20 tcatgagaaattg[g/a]ggaaagcttctctaagtagggacatagacaaggattaaatgagataatgcatggaatgtg/g /MACROD2/MACRO domain containing 2/ 2477/12/rs9658625/51783669/[g/a]/tgcccgctggagaccgcaccatggagccaggcggggcccgtctgcgt ctgcagaggacag[a/g]agggctgggaggggagcgggagcgccaaccctgtggagatggtgagccgccctcgggggt/a /SOAT2/sterol O-acyltransferase 2/ 2478/7/rs6980283/146381187/[t/g]/attattgtagggataaggctaatgatgaaagtgcacatgatagatac tttcacataattt[g/t]ggtataagccttttttgcaggggttggctaaggtagatagctagtggatcagatactcag/g /CNTNAP2/contactin associated protein-like 2/ 2479/7/rs2075013/77811392/[t/c]/cagcaaatgcaagcaggtggtgactgcaagaggagcaaaactattaga acttcctacaca[c/t]gaagagcagtcccaagcatccagggaaagatgaaaaagctgtttggtttggagacagact/c/ 30 MAGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2"/ 2480/1/rs2494884/50363992/[t/g]/gatttggccaatcattcaactaagaacagggtcagccagaatgtcttc tcaattaaggct[g/t]ttaagatctcctgatggctccttgcaggagcctgaacctagaaggtgagttagccttggc/g/ ELAVL4/"ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)"/ 2481/15/rs2307105/38053091/[t/c]/aagaaggcagcactgggtagccggttgctaggaataacagtctcaac ataatcttgtcct[c/t]cagaatctgagataaaacagggagtaagaggcacatgaggcattggaaatttaggaagag/c /EIF2AK4/eukaryotic translation initiation factor 2 alpha kinase 4/ 2482/1/rs1010294/15581127/[c/t]/cttcggcctctttgtagatatcatcctccagctttgccacctgcgact ggtacatctcaa[c/t]ggacactttgctccgcctgggtgcacaggagagatggcgtctgtttttcccttatctttc/t/ 40 FHAD1/forkhead-associated (FHA) phosphopeptide binding domain 1/ 2483/12/rs12371144/61612255/[c/t]/actttaaaatttgtaacattttacagtggccttcctaggcttcaag ttgaatatctctca[c/t]gttttattctaggaaaaaaaaattaactttttagggatgcggaaatggaggcccagagag/ t/PPM1H/protein phosphatase 1H (PP2C domain containing)/ 2484/11/rs7478756/7537608/[g/a]/tcaacttactgctttcactggaggcattaaaacctcaagccccaatct cggttcctccct[a/g]tatctgggtattttgcccctgggctactctagagtcagcttgaattaatttcactgttga/g/ PPFIBP2/"PTPRF interacting protein, binding protein 2 (liprin beta 2)"/ 2485/2/rs7591687/45609173/[g/a]/ggtatatcacagaataagaaatcaaagagtacaaacattgtgcccaag agaattaacatcagtaaaggagggacttataaaagaatttaaaaaacacataaaaaataggtttgggagcca[aa/gg]g caaaaagctaaatttggttgaaactgaggtaccagaggggtactctagagactagcataagccactgaatctgagtccat 50 (192) JP 2010-88432 A 2010.4.22 gtctctggtgagaacttgaaactatgtagacttagaacc/a/SRBD1/S1 RNA binding domain 1/ 2486/4/rs6827227/178992837/[t/c]/acaatcattcattgaagctgagctgtaccttttatataagtttttct gtataaatttcaa[c/t]gaatccttctccacatcttctgtggtaaagaaagcattagtgttgtcatttccatggaag/c /LOC285501/hypothetical protein LOC285501/ 2487/8/rs10086002/10429327/[t/c]/tcttgaccagaaaacattaactgtcctccctgattagagtttgttat aatactccattta[c/t]tctagtcacctctcaaggatcatggaatgagacatcatctctccactgaagactgcttgc/t /UNQ9391/tryptophan/serine protease 2488/2/rs990024/50196336/[g/t]/ccagtcttgggaaaagaaaaaaaataaaaattcagttggacaaaagcaa cagaaagagaa[g/t]tccaggtgggagaagtctgattaacttctggaaactttgcaatctatgacagttttatga/g/N RXN1/neurexin 1/ 10 2489/1/rs1797052/144439040/[a/g]/atggaagaggagctgctctgttcgttcactcaggaattctgtctctg caggtgagcatta[a/g]gcttgcaactcactggactttgaacaaagattgatttaaaagctaatgtatttaacaggg/a /PDZK1/PDZ domain containing 1/ 2490/16/rs2667672/1476381/[t/g]/gcaagggcagctccctgaaggccgggtccccgatcacgaagtggatgg atccgggcagca[g/t]ggagtctcggccgtgcagcaccagcttgttgtcattgtcctcggtggcgtaggacaggag/g/ LOC390667/similar to Neuronal pentraxin II precursor (NP-II) (NP2)/ 2491/12/rs3803039/77129759/[t/c]/tacatgagaaattcagcattaaagaacactgaagcggtaaggtcact gtggaagaggaag[c/t]gtttatactgtaaaagaaggttagatttgcacagtctactgggtaggtattgtaaataat/c /NAV3/neuron navigator 3/ 2492/4/rs2452593/95706737/[g/a]/atcactgcttactttgtgtcaagcactccaccagatatgttacataca 20 ttacctcattgc[g/a]tcctcaaaacagttctgcaagggaggtattatgaccctcatgtcaacaaagaaactatat/a/ PDLIM5/PDZ and LIM domain 5/ 2493/3/rs7640164/71540548/[t/c]/ggtggatgttctgctctgccatgatggaagactttctctttttcacag cataaaggcaat[c/t]cttttcatttgctctaaatgggtaagtagaggcaaggggcagcagacaccctgtcataac/c/ FOXP1/forkhead box P1/ 2494/18/rs182680/8611430/[g/a]/tctaagccaaaaattggattaagtttccagtcattgcaggctacttaat gtctgttagat[a/g]tggtataggtataggatattttgtttaagagcgaggactgttttaaggaactggttttac/g/R AB12/RAB12/ 2495/2/rs4952220/31619060/[a/c]/accaaacaataggttgatgacaagaaactcactcaaatataacaatat agtcagggtaaa[c/a]gtaataaaaaggggaaaagatgtatcataaaaacattaaataaaggaaggtagggagagc/a/ 30 SRD5A2/"steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid de lta 4-dehydrogenase alpha 2)"/ 2496/19/rs7257560/48558663/[c/t]/gcaggacacccagggatctagcgtgggggaggagaggagcctaatga gaaaatgaccatc[t/c]aaagcctgcccttcattggtctggttcacgtctccaaaccagcttggatggtagcagaga/t /CD177/CD177 molecule 2497/19/rs2238646/18199101/[a/g]/gtggggaaactgaggcttccatggacgcggtcacgggcatgggtctt tgttgcagaaagc[g/a]agacccaaactcagggccccctctcccagcacccctccacgcaactccccacgtgatccc/g /PDE4C/phosphodiesterase 4C 2498/10/rs7093791/18663469/[g/a]/aatttcacattctgggatcttaggttatacttgaaagcacttcacat tgacagctttgac[a/g]taaagggcaccttcatttctggccagtttctcattctcagcactatggacatattgtgca/a 40 /CACNB2/"calcium channel, voltage-dependent, beta 2 subunit" 2499/5/rs7722612/177759075/[t/c]/cccagtccaacacttttacattttgggagccagcaccttctcctttt tgttgaagccagt[c/t]tctcttgtttgtgactgggccaccttgttgagccgattgctgggaacatggaagggagca/c /COL23A1/"collagen, type XXIII, alpha 1" 2500/15/rs4318151/48516566/[g/a]/gtgtattttttgttacttgcttgtttaacccataacttcctaacttt tacatctctctgg[g/a]tactctcttcatatttatgtatgttgcattgctttactcacgtttgcgttgttatgctca/a /USP8/ubiquitin specific peptidase 8 2501/22/rs2050140/35301903/[c/a]/atgctcttatcccatctgggatttgactcatcattaggatgaattag gatcattaggatc[a/c]atccgcattaggggatacagtctacagtcacagacctgcacagacctgctgggttgcaag/c /CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 50 (193) JP 2010-88432 A 2010.4.22 2502/22/rs5754063/31119520/[t/g]/agggcctatccttccaatcttgcgtggacctacacaataggaagggg caaattaaacaaa[g/t]gagcaggtccagtcagtcgctgagatcaactgtgatatttgcatcagttaaagttctatc/g /C22orf28/chromosome 22 open reading frame 28 2503/18/rs7238217/54378800/[t/c]/tccctcttccacttataaggacccttgagaccaagtgggaccacctg ggtcaaagataat[t/c]tccccatgtcagggttgataacctcaatcacatctgcaaagtcccttttgccataattca/t /ALPK2/alpha-kinase 2 2504/13/rs655653/97735072/[c/t]/cagaggatctcagtctgcctcagagtaatttgagtgaagtgttggatt aaaaccaggctc[c/t]ggaatcgttcttcctgtgccagctgctagctattgactctccttgagctgaggcacactt/c/ FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derive d)" 10 2505/4/rs4688957/5822345/[t/c]/gcctgaagctgagaagtccccgcatgacagggctgtgattttaccacct tctcccagagc[c/t]tttcaagagaaacagctatggggggacagtcagacagacatccaaatgaacaggtgggct/c/E VC/Ellis van Creveld syndrome 2506/7/rs1029482/43221135/[c/a]/ccaggaccctggccaggaagagcaaagtgggacagaagaggcaggtgc aaggtagcctac[a/c]ccttttgggtatttattcacttactcttcctgctctccttgggtttgctttgttcttttt/a/ HECW1/"HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" 2507/2/rs212755/32277523/[t/g]/aatttggtgacattgcatgcagccattaccaccatccatctccagaacc tttttcctcct[t/g]ccttccttaaattccatgctcattaagcagctttccttttcctcctcctcacagcccctg/t/S LC30A6/"solute carrier family 30 (zinc transporter), member 6" 2508/2/rs6760538/133094296/[g/a]/ttacatgaaagttgataaatacccaggcagttccctccggaggcagg 20 aggctgcagctcc[a/g]gcatgagttgtctcaagatgccattagtggcctcagagaaataagccctggggactggag/g /GPR39/G protein-coupled receptor 39 2509/2/rs7593154/45516387/[g/a]/gaacaccccggatactctgctgatacccagaaaggggtagaagtgagc tattctagtcct[g/a]gagaaaggattacactacccccaccctaacaaaattttaaaaaataatccttactcagat/g/ SRBD1/S1 RNA binding domain 1 2510/11/rs2186775/70966737/[g/a]/tcacatacacacattcaaacagaaacaaccccccatacaccctccac acactcctctagt[g/a]tctgggggcttcagactctcacagcttgaagaggagacacgcatctctgctgagcgagcc/g /LOC727727/hypothetical LOC727727 2511/9/rs1535631/103473967/[t/c]/taagtgccctagttcacagggttaggaatcactatattatttagttg gtaattttccttt[c/t]tgtggcttctggcataagctctctctagaaccagggccaattgtttctctctaatgactt/c 30 /GRIN3A/"glutamate receptor, ionotropic, N-methyl-D-aspartate 3A" 2512/9/rs1323434/103472114/[a/g]/catgaccccaaggtaatacttcattttactttagctttcttgattgt ccattataattcc[a/g]tatgttgtatcttctgctgtagtatgctcatgttcttccatctaacacaggaatattctc/g /GRIN3A/"glutamate receptor, ionotropic, N-methyl-D-aspartate 3A" 2513/9/rs1323415/103466279/[t/c]/catccaaatcatgttattttagcatttggggatgattgacaagtgga tagaaactgcagc[c/t]gtgtttttatccagtgaggtttctctttgggtctgcagtctaaggagtggatctgggcac/c /GRIN3A/"glutamate receptor, ionotropic, N-methyl-D-aspartate 3A" 2514/6/rs12663896/155598360/[a/g]/ataaagtgctgatcaggttcacccagaatgtccctctaatgtttgt aaacatcacgaaca[a/g]tgggtgaactgaaatgtaatcacccaagtgactccttcagctacaatctgaaaagacaca/ g/TIAM2/T-cell lymphoma invasion and metastasis 2 40 2515/1/rs1501562/209139015/[t/c]/tggtttttaatcagtctcattagtcacttgttcaggttaaccctaaa tatccgactatga[c/t]cctattttatagaacccagtgtctagaaagcaattcccaaagtgtgaccaggaactctag/c /KCNH1/"potassium voltage-gated channel, subfamily H (eag-related), member 1" 2516/5/rs2662503/22507055/[t/c]/ggttgttggcagaacacccacgtgttaggagaacattcatacctttag ggagattgttca[c/t]tgggtgttgaaagaacaggtgcaatttttctcctgaatgcttcctgttttctagggaact/t/ CDH12/"cadherin 12, type 2 (N-cadherin 2)" 2517/9/rs10970978/32432256/[g/a]/gattctggtatgcagcagtggttgagaaccattgcgctatagttcac ggttctcaaaatt[g/a]taagaatcactagccccctcccaccccacgctccctgcaagacattctgatgcagcagat/a /ACO1/aconitase 1 2518/8/rs2927345/6718913/[t/g]/agattacactaacatccttaagaagcacgtaagagaaacagacacaggc 50 (194) JP 2010-88432 A 2010.4.22 acagcaatatc[g/t]aacacaaggtgaaggcaaatgtcatgaaaatgttaaaggcaagtgcttttaaaaggcccc/g/D EFB1/"defensin, beta 1" 2519/12/rs2272306/51840550/[a/g]/tgctgggacggctgcctgctggctccaacacctttctttgggtttcc tcccaatacccag[g/a]gttcttcccaaactctgatggcaacctcaagctagaaactccaggatacctctgactcca/g /CSAD/cysteine sulfinic acid decarboxylase 2520/18/rs637285/5949148/[g/a]/tcggaggggtccagaacccaaaactcagcacttccttaactcatgcatg ctctgaacctg[a/g]gagagggagaggtatgtgctgcctttcagtttctatgaggatggttttcttggaaagttc/a/L 3MBTL4/l(3)mbt-like 4 (Drosophila) 2521/1/rs3737696/15660856/[a/c]/gctgggggctcaaatggcctgaaccatgctacataaagcagccttgca aataaccactat[a/c]ctggctgagacacaagctgtagtcaatcaatggttcagtgtgttggcccatcaatgtcag/a/ 10 ELA2A/elastase 2A 2522/9/rs11791889/35850942/[a/g]/aggctgtggtctctcccaggtgacctccatcgccatgcagagctgct ctcacttctcctc[a/g]ggaaaggccagcgtcaggtattcctaggaggaagcccaggtgtgtccagagaacagtagt/a /LOC92973/hypothetical protein LOC92973 2523/9/rs7866673/70547425/[g/a]/taaaggtccttctaggagagaggtgaaaggtaattcttttgaaaatac ctattttaaagc[a/g]gtattattcccttcgagagacccattgattccctttgatggagcccaataccatgctgga/g/ PIP5K1B/"phosphatidylinositol-4-phosphate 5-kinase, type I, beta" 2524/9/rs3793517/76480451/[t/g]/ttagttgaggacgatactccagcttcaaagctgcaaagcatacagtgt gtgcaaagcccg[g/t]gttcagaggtcagcgtgcccgtcagtcttccaggaggagctccatgacttgtgctttgga/t/ RORB/RAR-related orphan receptor B 20 2525/17/rs2261081/899093/[c/t]/ctcaactgtgcttttggctccctataaacatatatagggaaaaggcctc tgtgtgtgcag[t/c]ctgtgtctctgaaacattctgccaattttgaagatggctgctattcaccaacctattaag/c/A BR/active BCR-related gene 2526/6/rs4354185/110408354/[a/g]/gtgtacatatatatacaaatatttgtatcttctggaggtgttcagga tgtggagcttcct[g/a]ttctgtgaaaaaccaagaaaaagatatggttgtatactcaaattgtacatcacgtttgtc/g /GPR6/G protein-coupled receptor 6 2527/5/rs6879158/150883585/[c/t]/tggacacctctgcttggatgtctcacaaacaactgggaaataatgtg caaaacagagctt[c/t]ggtttagcccataaacctgtcctgccttcccgtctgggcctttccagtctcataaatgca/t /FAT2/FAT tumor suppressor homolog 2 (Drosophila) 2528/5/rs756462/135395844/[c/t]/gactagggaggcatgggcctctgctggctgtggtcccttctccagcct 30 tcacttctcttg[c/t]ccctagatccttacatggattcattaatgctcattgtccctcctgggcccactcactttc/t/ TGFBI/"transforming growth factor, beta-induced, 68kDa" 2529/16/rs11863646/60578381/[a/g]/tcttcagatacaaaccccaagtaggctgacctactgattattcgca acaataatggaaaa[a/g]caatgagaatcacgacttaagattaagcattcaaacaaacatctccctctcccaacttcc/ a/CDH8/cadherin 8 2530/7/rs2267875/123172017/[c/t]/tagagacgtagtttaatgttttattttttcctattccttagtttctc acttattcaggac[c/t]atatatgttgaacttcacttagcaaaactgcacatactctttatataaaattaactgaat/c /WASL/Wiskott-Aldrich syndrome-like 2531/3/rs1347852/61055822/[a/c]/gtagtaaatggatagattaattgatgaatccctgccatttttctgata gtgtgtgccata[a/c]gtagttagagaaggctcaaaccttcaccaccatctgaatataatagtctttgcaaatact/a/ 40 FHIT/fragile histidine triad gene 2532/17/rs4968767/58797676/[a/c]/tgccagctacctaaagacttcttgttggaacagagaaaagatgacca ttttcctagagct[c/a]gagatgcattaacagaacagaaaggcagtaggaagatgtgaggcaaagtgggagaaagca/a /TANC2/"tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2" 2533/3/rs4141499/129124658/[g/t]/atttctctccttctgctgtgagtaccacatcaatcatttctgctaat tctttcatgttct[t/g]aattttattcagtaaattcaagctatgttggtatttttcttttccctcaatcttgcactc/g /KLHDC6/kelch domain containing 6 2534/21/rs3788111/44492599/[t/g]/ctggaaaggctgttgaggggcgggggcagctgggagaggctgtgggg gcagcagaagggg[g/t]tgcttagccgcagagagggcacgtggggaaaggccatgtgttcaaggccccaaaaggtgg/g /DNMT3L/DNA (cytosine-5-)-methyltransferase 3-like 50 (195) JP 2010-88432 A 2010.4.22 2535/15/rs1197690/39885028/[g/a]/ctgctcctctcccgctgggatgggaagtgtcccagcaag[a/g]tga cggggtgtatctggcagctaagaagagacctcttggttgatttaagtggggaggaga/g/MAPKBP1/mitogen acti vated protein kinase binding protein 1 2536/6/rs10806987/24423722/[t/c]/ctcctagtttatttactatccacagagagggctcattcattcaatga catctatcagtca[t/c]ctactgtgtgacaggcactggactaagtgttgagtatttgttggtaaataaaatagtcaa/t /DCDC2/doublecortin domain containing 2 2537/7/rs7789889/34109643/[t/c]/ccctctgttttccagttggtgcctcttgatgtccagtctgagttcctt tctagctaagtc[c/t]gagagaagattgttttcctctgaatttaagcttcaagtgactcccctagcatcgtatgca/c/ BMPER/BMP binding endothelial regulator 2538/8/rs2514344/99170315/[g/t]/tggaggacttcagcgcttaagattaaatgtttgagctgaagacaataa 10 agggatttgact[g/t]ggagagtgttagggtcatggtatggcctttctgtactcagatatatttggaactgtcttg/g/ C8orf47/chromosome 8 open reading frame 47 2539/13/rs2322829/35462562/[c/a]/acatcctttctcccagagggggcgctctttgatgctccagaacttca gtcccaattggct[a/c]ttgcgcctctgatctctgcttgagttctcactgtctctctgttcatcttcagttacaagg/a /DCLK1/doublecortin-like kinase 1 2540/14/rs2024109/73643475/[t/c]/gagacagtgcatgtgttttggtagaggagatgtaagaaggctagagt aatccggcgaggg[c/t]cagaatgcaaaggattttgaatgccacactaaggggcctaaattttatcctatgggtaat/c /LIN52/lin-52 homolog (C. elegans) 2541/10/rs4750565/6608207/[a/g]/attctttcttcttcttcctcaggatccttggtatttatgacctaatgt tctatgattaca[g/a]tatccacgatttctgatttagtgactatgcatccattcactcattcattcattcaacaaa/a/ 20 PRKCQ/"protein kinase C, theta" 2542/1/rs3817269/15928951/[a/g]/ttctttgaagtcagccatgatcaaaggctgtcgagaacctccctaccc cagcatcctgac[g/a]gatgccaccatggagaagctggcactggccaaatttgtggcccaagaatcgaagtgtgag/a/ PLEKHM2/"pleckstrin homology domain containing, family M (with RUN domain) membe r 2" 2543/11/rs1612783/15142305/[g/a]/gcaacagaaagttattgtagtctcatcccatatatagttattttaaa aagagaataaaga[a/g]cagaataatatctctacaatgagaaaatgccagaaaaaaaatgtactcttaaaacagata/a /INSC/inscuteable homolog (Drosophila) 2544/1/rs950493/6867391/[g/a]/tgctctagactgcttagactgcgcattcccaggattttagcactacaaaa tgaacaagta[a/g]ttattccttcaacacataaggcatccaagaacacagggttcacaaatacttcctcaaaat/a/CA 30 MTA1/calmodulin binding transcription activator 1 2545/1/rs1876848/6876262/[a/g]/taggtttgcagaattctaaatggagattgtagcttcacatgcgcactga gggggttgtgc[a/g]ttttcataggcttatgttccatcgggcttctgcatgatcttggaagagagagactaggtg/g/C AMTA1/calmodulin binding transcription activator 1 2546/4/rs1848067/83801589/[a/g]/gtgaaatgtaagtaccttttctctcttactgctgcaaactgctgacag caatgtattatg[a/g]gacccctcgtcagttgacagttgaagtggaaatattgttgtaagtaatgaatttgttgat/g/ SCD5/stearoyl-CoA desaturase 5 2547/4/rs993380/83803520/[a/g]/taaaaatttaacaaaattcttgaaggtcaatatgggatagcctcaagcc tcggacacaaa[a/g]gagtttgtattcacactcaagcttttctttagggcccctaactgggtgctcacaaggaag/g/S CD5/stearoyl-CoA desaturase 5 40 2548/10/rs2271359/120854591/[t/c]/gggtgtgcaaaaatctcgggaaaataaaactttttcgaagggaacc aacgggttccatcc[c/t]ctaaatactgcacgaggctgcccaaagatccccgtgtgatattttttaattatggaagat/ c/FAM45A/family with sequence similarity 45 2549/12/rs1317648/50927395/[t/g]/gagcaaaggctgagggaaagagagaggtttgctgaaagcttccaggg ggcttgcttaaat[g/t]gcccctgctggtgctgggagttgctggcacttgtgggtggggagagggagccaggttgca/g /KRT7/keratin 7 2550/12/rs3815210/119064052/[t/c]/ccagcaggtcaaatgcagctattataagcatttgcagtgcca[c/t ]gcagcactggccacagtcgcattttacatctctttgtgtggttatttgattaatatccat/c/GCN1L1/GCN1 gene ral control of amino-acid synthesis 1-like 1 (yeast) 2551/15/rs8028632/73108315/[t/c]/tctccctcctcgtgagacctcatggttgtcttgtcagtcaaatgctc 50 (196) JP 2010-88432 A 2010.4.22 tgaaaccccattg[c/t]ctgaagctctaggttcaaactttgctccttcaggtgttcagagctgccccaggggccccc/c /PPCDC/phosphopantothenoylcysteine decarboxylase 2552/16/rs403632/77799255/[g/t]/tctttaccatatattgtttatcagaaacctctgtaccctttcctttaa aggagtcaatat[g/t]catttgtattctgtgctgacaactataaattgatggctagcagttatcaaatgaatgttg/t/ WWOX/WW domain containing oxidoreductase 2553/19/rs12611226/53162033/[a/g]/gggataagcctagggctcaagagaccaggcatttcatttctttctt tctttttttgactc[g/a]atggatgtttaatgatttaaaatttaatttaacttaattttagattcaggggatacgtgt/ a/BSPH1/bovine seminal plasma protein-like 1 2554/16/rs12446070/80473160/[g/a]/tgtgaggctggtggggaaaggttagaattgtactcataatcaaaga caacagactcctgg[a/g]ccctgagtgtttagtaaagggagaaagctcagggcatgtttcatctcttacactatttga/ 10 g/PLCG2/"phospholipase C, gamma 2 (phosphatidylinositol-specific)" 2555/13/rs9518538/101227666/[g/a]/agcccctattctacctagatttctctggatgggagtcagtgcaaac ttcttttgttataa[g/a]aaggttgtattctgtcactagtgagtaacggaggaagagcaattaagaatggccttttat/ g/FGF14/fibroblast growth factor 14 2556/2/rs13029846/15592137/[c/t]/tttctatgtcccactaaatatgagaacaaatggttacttacctgtga ccagggtggtaaa[t/c]agctgtgttgattccatgaggataatgactactgaagctgaaacagtgactttcttggta/c /NAG/neuroblastoma-amplified protein 2557/2/rs4668909/15525293/[c/t]/atttacttggaaaagttcactaatttcagtagttcttgtctcttcttg agctccttttcc[c/t]ttttattcttggcaggctcttcatcaggtggtgaaagctcttcataggagatactgtcaa/c/ NAG/neuroblastoma-amplified protein 20 2558/2/rs2031011/15465841/[c/t]/gtgctatacttcagaataaaaatataataaagtaatacgcatacttga ctattcaaagtc[t/c]ggttaagattatcctcatccaacacctgaacaattcagatcctctggtcattttaactct/c/ NAG/neuroblastoma-amplified protein 2559/9/rs10760581/130677256/[g/a]/actttcctcatttatgttgataagtttgccttcaagaagtttctct ggatgcagatctca[g/a]gtttcccaaactgtgaacagctgcagagttgccatccccacagctagctatttcttccat/ a/CCBL1/"cysteine conjugate-beta lyase, cytoplasmic" 2560/5/rs400155/22587514/[c/t]/tagcaaacctgtcattctagatgcaatttctttatcagtgttcatgttt atcataaaaaa[c/t]atgtgatattcttgtgagggacacagatagttatctaaaggttaaatgcctatggaaaaa/c/C DH12/"cadherin 12, type 2 (N-cadherin 2)" 2561/11/rs6578875/7549612/[c/t]/gtccgtgctttctttctgcgctcagctcccaaggggctcctgggccgg 30 gctcaggtggca[c/t]cagtggtggttctttgtccctgtgcagtgctggaagaagccactaggtgggagtcaggga/c/ PPFIBP2/"PTPRF interacting protein, binding protein 2 (liprin beta 2)" 2562/13/rs11842667/100704146/[t/c]/tgtaaataaagttttattggaaaacaaccattctgagacacactc acttttgtacaattt[c/t]agagttgagtagttgagacagagagagggtggtctacaaaaggcaaaatgtttactatct /t/NALCN/sodium leak channel 2563/22/rs2032574/25218725/[t/c]/gagtttccatttcccaccaccaaagaggcagcttttagtaccttgaa aacatagggccca[c/t]actggctttatttttaacctacccacacagggcccccatcctgaaagaagttcacatata/t /TFIP11/tuftelin interacting protein 11 2564/3/rs6770096/32971513/[t/c]/taataacatatctcaggcaaagtatattccattgagccagatgtatga agaaacaattag[c/t]gaagtgatgaaaccagatctcaattatttattgtaaaggattatctgttaattgaaacca/c/ 40 CCR4/chemokine (C-C motif) receptor 4 2565/1/rs7540065/171715659/[g/a]/aactggcttaaaaccagttccttttgcatgattcagcaaaacagtct ttatggactcaca[a/g]tggaaaaagaactcctaacttttctaatttatcctccttttaacgatagaggaggaaacg/g /PRDX6/peroxiredoxin 6 2566/7/rs7802749/94625577/[a/g]/taaaattagattgccaacacatattataattttagaaaatttccaggt ggataactgcct[a/g]aatacagaaaatcagaatgttaatgcattttgaagaaaacataggcccaaggcagtggct/a/ PPP1R9A/"protein phosphatase 1, regulatory (inhibitor) subunit 9A" 2567/9/rs7862571/72344397/[t/c]/ctggcaaactcaacgccatgcactcagctgacacagctaattcagaag gaaaatacagct[t/c]ttccctctttcacttcattctgtcctataaacatagcccaagaaacaaaattacttacaa/c/ TRPM3/"transient receptor potential cation channel, subfamily M, member 3" 50 (197) JP 2010-88432 A 2010.4.22 2568/9/rs10814288/35857901/[a/g]/cgtgaatctaggtcagtgtccactgcctgtgcactgagttatcagaa agaaaagctggaa[a/g]aggctgagcaccaggcaggggcaactatggcagggtcccagggcatgaggtgaggatggg/g /OR13J1/"olfactory receptor, family 13, subfamily J, member 1" 2569/2/rs9808377/179129940/[a/g]/acagcattcctagcaaagacacggaattcatactgggaattctgagt caagccagagatg[a/g]tgaattgagtttcagtaacattggtgaagctggccttggtccatctgccatctggaaggt/g /TTN/titin 2570/2/rs3731750/179114249/[g/t]/gggtctgggaaaccaagtcgtccttccaaacccatcgttgccatgga tccaattggtaag[t/g]acattttgtatcagtcaaattgattgagttacaatttatatgtgggaaaattcacctttt/t /TTN/titin 2571/2/rs3813250/179104204/[a/g]/attagaagaaaagtcactggaagaaaaatccacaaccagaaagatca 10 agacgactttggc[a/g]gcaagaattctaacaaagccacggtccatgaccgtctacgagggcgagtctgcaaggttt/g /TTN/titin 2572/4/rs515800/138173257/[t/c]/aaaaagtactaataatccaactctgtaggctctcattcatgctcactt atggaagaaggc[c/t]attccctaattatccctttaaatagaggtaactagaagttcatccaaaggtttccactct/t/ LOC729578/hypothetical protein LOC729578 2573/4/rs2279994/37266965/[a/g]/aataatacaaaggtaaagctggagaaatactacttctaaatggaggaa tttgtgatgagc[a/g]tggggtcacttttaaagaccatgcgtgtattcagtgcatttatccagcttggggcatgat/a/ C4orf19/chromosome 4 open reading frame 19 2574/5/rs7717533/155907842/[t/g]/caatccaccccaccccaatacctgacaatttcactggcaagatgaat atgctcagctttg[g/t]aggatagaagtcgaatgtccccttaccaactttggaaggagaagagttaattggaaaagt/g 20 /SGCD/"sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)" 2575/7/rs2116531/14421132/[a/g]/tgtactctggtgagactctataggagggtttttttttattttttgttt gtttgtttcaac[a/g]tagatcacatcagaaagtcttgaaatgactaggtgctttcttcagagtatttaaatttta/a/ DGKB/"diacylglycerol kinase, beta 90kDa" 2576/2/rs1465821/85854766/[c/t]/ccttcctcgggtcctccttgcctttggccccacgaagaccaacttctt gggcaggagaca[c/t]gggagggagagcagattttgcaaaacaatattacgtcctttatgccactaatccatgaac/c/ ATOH8/atonal homolog 8 (Drosophila) 2577/2/rs2112040/45605718/[a/g]/gttctaagatcattcaatgggtaaagaacagtcttttcaacaaatgtc ggtaggactact[g/a]gatagccacaggcaaaaaaaatgaatttgaacccttactttacaccatgtacaaaaatta/g/ SRBD1/S1 RNA binding domain 1 30 2578/5/rs467604/178600590/[a/g]/actcaagctcactcctgccattaaactctcctgagatttgagtttcct cctctttcacaa[a/g]accggaaatcccttgtaagttaagccaagctcattaacgttgtcttctgcggcatccata/g/ ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2" 2579/5/rs4701085/178606682/[g/a]/actcacaggaaataaaaaagaccttccctgaggaagcctagacacct catgtgccagaca[a/g]agattttaaataaattgtcttaaatgtgttcaaagaactaaaagaaaccatgggcaaata/a /ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2" 2580/8/rs4501569/52601823/[g/a]/catccctctgatcgaatatgttctttcctaacatgtgatgtgatgtga ggggcatttggc[g/a]tggagtgggaatttaaagatgctgttgctaataatgaccaggtcacctcagagagtgcct/a/ PXDNL/peroxidasin homolog (Drosophila)-like 2581/11/rs1945453/21350871/[c/t]/tggtctaaggtaatgtttccctccagttatttctaatgtaaaaaaat 40 aagaatgttacag[c/t]agttgctatggttaaatatcctgaggtgcttggtgaaaatgcagattcgtgaaaccaccc/t /NELL1/NEL-like 1 (chicken) 2582/1/rs3766160/15681459/[g/a]/gagtccggctcgctggccgtcagtgtctctaagattgtggtgcacaag gactggaactcc[a/g]accaggtctccaaagggttcgtttctatctgggtgcacttgggggtgaggttgtcaggga/g/ ELA2B/elastase 2B 2583/8/rs3812430/71212926/[t/g]/tcctgagcacctagggtagccagttattttatacctgtccagaaatta atcttttccttt[g/t]gagtagttggtgcctgaccagttttcatttattggtactatattatctactgtgcagtgc/t/ NCOA2/nuclear receptor coactivator 2 2584/8/rs503985/103167437/[c/t]/attttaggtgcccaaatttaaacatgttttaaacatggtacccaaatg caatgtttactg[t/c]tgactctttcccatccttaacactgcaaaaatgtcaggaaaaaagattaagcagcataaa/c/ 50 (198) JP 2010-88432 A 2010.4.22 NCALD/neurocalcin delta 2585/8/rs652008/103179097/[a/g]/gtcagagcagagagcaggaagaccaaggtttcagtgctaaaaatgatg aaatcagttgat[a/g]agagtcttgtataaggaggtacttttgaaaagaggttattgatgattgccagagagggat/a/ NCALD/neurocalcin delta 2586/8/rs620643/103181593/[g/a]/tatttgattgttttgatctgaacaaaacttgttcatcttggtttgtgt gctatgtatgct[a/g]aagaggccttttgttgtaagtgttgataaatgaggaatatgaaaataatttaggttttat/g/ NCALD/neurocalcin delta 2587/13/rs4335654/101307317/[t/g]/ctcttttgcacgtggtctacggtataggtaatagaaacagtattat aaaaggtccatagt[t/g]gaaaggcagatgagttcattggagatgtttacattaacggggagtcattaagtatcaact/ t/FGF14/fibroblast growth factor 14 10 2588/6/rs1617105/43721158/[a/g]/gtgggcgggtcgcagcaattgaaaggggcggggcccatggggccaagg gaggtgtgggcg[a/g]gatctgagatgagtggaatgggggagaccctggggggcgggcctggggacggtcaagagg/g/ C6orf206/chromosome 6 open reading frame 206 2589/1/rs1754351/172998219/[t/c]/agacaaagggaacctgtgttttcactgtctaacctaagtttgcagaa ggcacagaaagtt[t/c]ctaacgtagtaaagctaaatggaaattagcttattgaagagagggagacagagcattcct/t /RABGAP1L/RAB GTPase activating protein 1-like 2590/1/rs704852/165730540/[g/t]/atccaggaattataggagatacaaaatgccgaggaatgcactactcat gatcttttttga[g/t]ccttttaacaatccagagacatgggctgtgtaaagccacagtgcaaaatacaattaggaa/g/ CD247/CD247 molecule 2591/7/rs3807816/8241489/[a/g]/caatgttagcgctgacatttatgtgcctataacatatctgagcagcatg 20 ttaaacctctt[a/g]taaggtccagagctcttcaagcagtgtttccaaattcttttgaacccatgacccaccaag/a/I CA1/"islet cell autoantigen 1, 69kDa" 2592/8/rs4404876/10440498/[g/a]/aacaagcagttttcagaccagcagtagtccctgttccacacttcagaa gcatttccctac[a/g]agacccagactttaatcaccaagaaatagaggccacctggctaccaagcccaggctttct/g/ LOC346702/similar to hCG1643218/ 2593/9/rs11103509/136793924/[c/t]/actccatcggtcctgctgatggatggagctcggggccagctctcag ctctcactgcagga[c/t]gcaggtgccccaaaccccactgggaggaaaggtggccagagcgtttactgagctcagcgt/ c/COL5A1/"collagen, type V, alpha 1"/ 2594/10/rs10887650/88451679/[t/c]/ccaggctatgggattttgaatgcattctgaaggaaagtggaactag caaaggctgtaggg[c/t]gcctttcacactatagctgatgaggtgttcttcatctagaccacaatggcaatgtgggcc/ 30 t/LDB3/LIM domain binding 3/ 2595/12/rs12580349/47722991/[g/a]/gtgggggaatgaaggacactgttgaggaagactgggaagttcaggt gacaccacaggtct[a/g]caaatgatcatggccaggaacagtccaggactccccaccagagaagctgtacagatcaca/ g/MLL2/myeloid/lymphoid or mixed-lineage leukemia 2 2596/21/rs8127595/37271110/[a/g]/gagggacacaagccagatcatctctaacttcccctccatctctcaaa ttctgtggtcctc[g/a]tacatttacaatatgatgcaatctacaaacatttgatattggtgctctcttattcacctt/a /HLCS/holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP -hydrolysing)) ligase)/ 2597/1/rs1878076/163883944/[a/g]/ttcagtcatttttatttattttcaaagaggtgttcagaattcacact ctgtttttctttt[a/g]ataactactgtggcttcctcctcatgctgactttctacacttgggaagagaatgtgggca/g 40 /MGST3/microsomal glutathione S-transferase 3/ 2598/1/rs2275863/199595447/[t/c]/gcactcagcccccttctccccatccccaggccacctgggacctgagc cagtcagctccag[c/t]gttgctctttgtccttcccacttttcttgcagatcaatgttctccgaaacaggatcaacg/c /TNNT2/troponin T type 2 (cardiac)/ 2599/1/rs915184/232632410/[t/c]/cttggagtgcagcaggtacagggaaggttaaggcttaaaaatccattt ctgttgttgtca[c/t]cgtgagttcatgattgcccaacattgcttataaagttatagaattttggggctgaagctc/c/ TARBP1/TAR (HIV-1) RNA binding protein 1/ 2600/1/rs270524/232651626/[t/c]/ttttgattttagacatttttcctccacttctttgtatatattcccttt aaccttcagtgg[t/c]ttcctattgcctttagggcagagacaaaggtcctctgcatggcctgcaaggtttcctggt/c/ TARBP1/TAR (HIV-1) RNA binding protein 1/ 50 (199) JP 2010-88432 A 2010.4.22 2601/10/rs11254305/17054990/[a/g]/cccaaacagacatgctaccatctttctttttctctgccaagccatt cttcacacactgct[a/g]cctgttgtcactgtagaatacagctctgagtatgttattcccgttttacagaaaattttc/ g/CUBN/cubilin (intrinsic factor-cobalamin receptor)/ 2602/10/rs648768/34530607/[a/g]/attaacatacagtaaaatggactttttttgtggtatgaagttctgtgt gttaaaattcaa[a/g]gagttgttcacccaaaaaagcaactctagggtatgttaaaaaataaaatgaattttaaca/g/ PARD3/par-3 partitioning defective 3 homolog (C. elegans)/ 2603/18/rs7231100/74456072/[t/c]/tatgatattcatgtatgttaaatctcacaatgctatgtacacaacat ggtgccaggcttc[c/t]ggtaaattctcaataaatgttagccctgctgtgatttctgaaataataaaaatgtgttca/c /LOC100132713/similar to hCG1654128/ 2604/15/rs1043627/39907192/[g/a]/gcaggaagcgccgcgacctgcacaaagtataaaagttataaataagg 10 ggctttcaaaaca[a/g]ggcgggggcaaatctggagtggggcggcggttgccggtggcctcagacatgcagaagggg/g /MAPKBP1/mitogen activated protein kinase binding protein 1/ 2605/11/rs7395852/5733786/[g/a]/gaccagtctaataattaaaccatattttattcgacaaaacctaatgag tccattttttat[a/g]aaaagacaaatctaagtagaaggagatgatgtgagtcctcttttcaatgatcacaatttt/g/ OR52N4/"olfactory receptor, family 52, subfamily N, member 4"/ 2606/9/rs656074/9589879/[c/t]/tgctattaaatatctagttattagtcaaataaagaatatttaaagacttt atgaagcaaa[t/c]tgtaaaactcaatttaaggatattaaagatcaataggtgaagaaatatgtcaactgacag/c/PT PRD/"protein tyrosine phosphatase, receptor type, D"/ 2607/15/rs10519833/31681787/[t/c]/gccagcctggtttttctttgcctacccaaaatagggcatagctcca gcccaagaacagtt[c/t]gtctctaaaagtatgattcctaacataaaaactctaagtggtgtatcttaagcttttaac/ 20 c/RYR3/ryanodine receptor 3/ 2608/14/rs12879377/68864952/[a/g]/cgccaagccctatctactcctcttgtagggctgatccggtcccgag tgcgtggggcggac[a/g]tggctgcagctaccgttctcacctttctggatagccactgcgaagtgaacaccgagtggc/ g/GALNTL1/UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminylt ransferase-like 1 2609/2/rs3770267/45543819/[t/c]/atgtaacacaactgtctatagcataagatagattggacggagaacttt gccatgagtgaa[c/t]ccataccataattcaacgaggccacccttcctgtctctgtaccacattataaaatcactt/c/ SRBD1/S1 RNA binding domain 1 2610/2/rs1533949/36634524/[t/c]/ccacccatcctgaaagttcacagctggttaactgttcctcttccttgg ggaccaataata[c/t]gacactttgcccgggagggggatattgctcaaggggagaatactccttccccttttttgg/c/ 30 FEZ2/fasciculation and elongation protein zeta 2 (zygin II) 2611/1/rs4657489/164122744/[c/t]/aacaatagagaggatgatataaccaaaccctatgtacatgtcagcca gattcaacagtta[t/c]ccggattttttagggcccatttgtaatatggcccaggaggaagaaaatgcctgaacaatc/t /UCK2/uridine-cytidine kinase 2 2612/1/rs4920338/18863380/[t/c]/tcagtggcagagctgggacagattcccttttgttggaaagatgatctc gtgcctctgagg[c/t]ggtagtgacctctctcctggcccctgtcagcctatggccacatctgagtttttccttccc/c/ PAX7/paired box 7 2613/18/rs10502849/40866089/[t/c]/ttttaatattgagagttctgtacctgtgtgtatcttcctgagtgga tggttgactctgtt[c/t]ggaaaggactcaagttcctgaggcctgatggtgcttgtcacctatgggttcttaataaac/ t/SETBP1/SET binding protein 1 40 2614/13/rs1077728/50708717/[t/c]/taagcaattacatttgtgataagccaatgtaggagctttgaaagcaa cacatggaaaaga[c/t]atgattgcatactgtagaactcctcaccaatgcggaatatgtgaatacatatgatctgtg/t /FAM124A/family with sequence similarity 124A 2615/1/rs4908872/6240656/[c/t]/gctctctttctcatgccccggtccttatgggcatctatagtaccagata cgccccatgtc[c/t]cccagagaggaagtatctccagctcaaggtggggggccactgccgccttagccaaggccc/c/G PR153/G protein-coupled receptor 153 2616/5/rs813035/148700280/[g/t]/gatcatctgatcacacttgtgccaacttgattcatattgggcattact aacaacccctgg[g/t]caaggtaaataggttgaacaatcaataacattatccctgcctgcatacatgtgaacaaaa/g/ AFAP1L1/actin filament associated protein 1-like 1 2617/7/rs802787/103336960/[t/g]/ctgctgctaatgccctggggagtatgggccttggcgataattagcaag 50 (200) JP 2010-88432 A 2010.4.22 tttgtaataggt[t/g]ctacttagtcttaatgtgaaggataatgaaaagttagcatacaggccctgcatttctatg/t/ RELN/reelin 2618/6/rs924928/157859789/[c/t]/tgcgctggagaaataaccatcaaagccagtccacggtggcggggaagc cacagatggaag[c/t]gctctctggcttaaatccaaggttccaggagggaaacattgacatggattctaaataacg/t/ ZDHHC14/"zinc finger, DHHC-type containing 14" 2619/20/rs6141035/9720904/[g/a]/cattagcaggggaaatcaatgaagatgtgttgaatatttaaaggatca ttccaagtaacc[a/g]tctctcactaaagaaaaacagaagcagaaagtcatacaatctaagataccatgtctaagg/a/ PAK7/p21(CDKN1A)-activated kinase 7 2620/19/rs283526/55127674/[c/t]/tggcctccctcctcaagaaggagctggaacagatggaagacttcttcc tagatgccccgc[c/t]cctcccaccaccctccccgccgccactaccaccaccaccactaccaccagccccctccct/t/ 10 ATF5/activating transcription factor 5 2621/7/rs10263826/107208308/[c/t]/ggagtatggaatttgtatactgctataccatgaaaacacagtgtac aaagaaaagccaaa[t/c]acagtttttatttttatatcttgaggacagttgaactgatctgcctatttctaattttca/ t/SLC26A3/"solute carrier family 26, member 3" 2622/2/rs1001238/179172772/[a/g]/aataatctaggcccaccatcaattgatctaaaagaattcatggaggt tgaagaaggaacc[a/g]atgttaacattgtggccaaaattaaaggtgtgccattcccgacactaacctggtttaaag/g /TTN/titin 2623/18/rs2016524/63488431/[c/a]/tgatttcttctctaaaacaacatacctatcagaatggttacataaga actagtgataaaa[c/a]caaatattggtaatgacgcagagcaactggattgcgcatacattggtggtagggatgaaa/a /LOC643542/hypothetical protein LOC643542 20 2624/5/rs190409/80407077/[t/c]/caacaaatcccaactgttgagtcctgatggataagtaagcaacaaggaa ggggcctccga[c/t]gggggaaggctccaggtaggggagaagaatgaacaattgttctgagaaacacaacccgct/c/R ASGRF2/Ras protein-specific guanine nucleotide-releasing factor 2/ 2625/4/rs4538488/95994345/[t/g]/ctactgtgaagctctctattccttctagcaagccccaagatgcctcat ctattgaataag[g/t]cctttcgtatcctgaaatgataaaaaatggacatgatgctctactgtaattgtaccctaa/g/ BMPR1B/"bone morphogenetic protein receptor, type IB"/ 2626/9/rs1999741/9139128/[g/a]/gatagatagacatgaacctgaggtgagcgataattttataccttgctca aggttatccag[a/g]tgatgctaggactctaacctaaacagtcagactgcggaagctgaactcttaactactcca/g/P TPRD/"protein tyrosine phosphatase, receptor type, D"/ 2627/5/rs17160255/106979256/[a/g]/cgaaatgcacaagtacagattcccattatgcatcctttcctctctg 30 gtttctagagagca[g/a]accaaaaaacaaacaaacaaaaaaattctcttgcactctaaaagcttgcttcacttaaaa/ a/EFNA5/ephrin-A5/ 2628/18/rs1835500/38586490/[g/t]/tttccccatgagagacagcaagaaagaagggaagcggtgcttaatgg aagatagtagaac[g/t]tgatggatattttacttaattagatgtgtgaccttgagccatttcttaaccactgcttaa/g /RIT2/Ras-like without CAAX 2/ 2629/15/rs2733332/55175641/[t/c]/tttactagctcagcattttcttaaaccatgattatggagacactgat cttgatggatgac[c/t]gtggaaaaacggttccacagtgaaataactttggacaccattgcgtatcagttgttccct/t /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 2630/1/rs441374/61442932/[a/c]/tttaatttccagctgtgggtatttgtattatgtctgccttagtccacct 40 tctgccccccc[a/c]acccttgggttgatgtggttactgaagatagtgaggctatctggagattggacattgacc/c/N FIA/nuclear factor I/A 2631/12/rs2280697/51804087/[c/a]/agggcctggcttgggggtgatggactctcacgtcttggatgcatggg ttgagtcaccagg[a/c]atgatctcattcacgacttattcttctctggctcaggcaactttctgggggctggtgaca/a /SOAT2/sterol O-acyltransferase 2/ 2632/15/rs8041826/78490041/[g/a]/ccttggggtaagttagttcacagaacatagagcttttggtccaagta ccatagttcccaa[a/g]caatgcttgcatttactgctttattgtctgtctttattgagattcactaagacacaaggt/a /ARNT2/aryl-hydrocarbon receptor nuclear translocator 2/ 2633/16/rs17139612/6221294/[t/c]/gtgtgtaggtgtgtgtgtgtgtgtgtgttccttataagccaacaggt accgaatttagtg[t/c]aggtctaagggatatgttgaaagatgaaggttataagtggaggtttccgtgtttaaattc/c 50 (201) JP 2010-88432 A 2010.4.22 /A2BP1/ataxin 2-binding protein 1/ 2634/2/rs6751576/152959988/[a/g]/gtcctgctccggtcagcccgtatttccagagtgttctttcagaactg gaaatgtctgtat[a/g]ttcagctgggttgccatggtgctgtgggacatgaggtggcaaaccctacacaagagttaa/g /FMNL2/formin-like 2/ 2635/4/rs2262366/68253660/[g/a]/ggacacttagattgattccatatcttggctattgtgaatagtactgta ataaacatgggc[a/g]tgcagataccttttaaatttattgaattccgtttttggatgtatactcaggaatgggatt/a/ LOC550112/hypothetical LOC550112/ 2636/1/rs998470/173468525/[c/a]/atctgaatcactcttctgcaagcatctttgattctttttcatcctttt gcttctgttata[c/a]cacctagtaaaattccaaactagaatcaatagtactattactccctgtctcctttgttct/a/ LOC100132316/hypothetical protein LOC100132316/ 10 2637/15/rs715338/55003159/[a/g]/agaaggaaagttggttaaaaggattgacaaaatggaaatggttcagat gtttaaatccat[a/g]tcctcaacttcggggtttgagtgtgtatgtctagattgtgattttgggttagtttttagt/a/ TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)" / 2638/13/rs9596219/49461448/[t/c]/tttaaatgctgggtagaaaaggatgacccagcaagtattcctgagtc tgaagaagaaaag[c/t]caggagtgagtttagtgttactaatggcagaggaaaagagggccttttaaaaaggaggca/t /DLEU2/deleted in lymphocytic leukemia 2 (non-protein coding)/ 2639/17/rs7217359/16958902/[g/a]/ggcgggggccctggtatctcgctgcccaggcagcggccgaagccagc aggccagcctggc[a/g]tagcaggtgtgaggaggaacttcctggtcttggcagcaagtgaaaaaggtccttgttttc/a /M-RIP/myosin phosphatase-Rho interacting protein/ 20 2640/1/rs3768142/235095187/[g/t]/actgagggtttgcgtatctttgctaataagtctaactggagaaacac tttctgatgaaac[g/t]ttactttcattttacaaaaacaagtgaatgtgcaaacttcatgtcaaacactcctttggc/t /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 2641/1/rs1766163/91087098/[t/c]/ttaaaaagtcattgagggaagtcatctaattttctttcagcttgtttt gaccccaaatta[c/t]attatcctgacttgaccacccaccttattcttcagagcactgaaggatgctaaaggaaga/c/ LOC149351/hypothetical protein LOC149351 2642/6/rs9397717/154790779/[a/g]/taggggtaaaaactgggcaaggtatatgaacaagagcaataaaggac aatttaaataata[a/g]attgacaacagctggtgacaagcagtactctatcaacagaaataaacaaagcaggtaccc/a /CNKSR3/CNKSR family member 3 2643/6/rs9294882/71706893/[a/c]/ccaacaggtgctggtcagaagaatattcctaaccttcccagcccagga 30 aatgaccttaaa[a/c]tactgcttctaatcatgtgctcaaaaaaaaaatctatttcgtgccctctcctttgtaaca/c/ B3GAT2/"beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)" 2644/4/rs3846232/4297960/[g/a]/ctgtgttagagtggaggtgaaggtccacagtgggaggagtgacagcttt gtggccagacc[a/g]gatgtccagtagttcctcattcacagggactgagatcctttcagtatagtctccagagtt/a/T MEM128/transmembrane protein 128 2645/1/rs4656994/159446501/[a/g]/gtatcgctgggggagggggtgctgagagggctctccttagtgaaggc tatgccacattca[a/g]tagcacttccgtttggcttctaggacctaccccttgggcttatggatgacatttatcagt/g /NDUFS2/NADH dehydrogenase (ubiquinone) Fe-S protein 2 2646/1/rs1005716/181426000/[c/t]/aatcgatatgaccattacacaaaaatcactttgcacattgcctggta agcacttaataca[c/t]gttaatagattactgttattgttacaactaactgccctgccagtactgaatttggtatat/c 40 /LAMC2/"laminin, gamma 2" 2647/2/rs6752375/32101446/[t/c]/gccaatcacattaaatttctaactttgcaaaggccttaacatgtttag catggagacaca[c/t]gactttaataggcttctaatgcagggtttttcaactttggcactgacattttaagctaga/t/ DPY30/dpy-30 homolog (C. elegans) 2648/18/rs3794938/17288554/[g/a]/atcctctagacgtttggattaagcaaaagaaagaggcagaggggatc tgaagctggatct[a/g]ggtgggctcctctttgaaagttcactcttacctgattgtcgaatccgctgaagagtttgc/g /KIAA1772/KIAA1772 2649/18/rs8092018/17301569/[a/g]/acaccccactagtatgacccataaaagagaggtagtaagaattgttg aatatgtggagaa[g/a]ttggaacctcgtacactgctgttaggaatttaaaatggtacagccgctttagaaaacagt/a /KIAA1772/KIAA1772 50 (202) JP 2010-88432 A 2010.4.22 2650/1/rs6540886/213464635/[a/g]/tttgtgacaaggaaataactactcaaatgacctggagtagagctaga gggagccaaggaa[a/g]cttacaaaagtgaaaacattatgcaaacatgaaattcaggactggcaactaccctttatc/g /KCNK2/"potassium channel, subfamily K, member 2" 2651/2/rs2303838/179153185/[g/a]/attttttacacattcatttcttatttacctactatttatccagatac tcctgggccacct[a/g]tcaatgtgactgttaaggaaatatccaaagactctgcttatgttacctgggagcctccca/a /TTN/titin 2652/15/rs2589949/88756019/[g/a]/actcagttttggaatttcatttcatttcatttaagattaaaaggtct ttcatgctccatg[a/g]taagtggtaaactagggatggatggatagatagacagctgaccatggtaatgtttcacca/a /IQGAP1/IQ motif containing GTPase activating protein 1 2653/19/rs15282/7740274/[a/g]/tccctggtgcttccagcctgcaagatgagctccttcaaccagcaagtccc 10 cagtcaaaag[a/g]gtgcacggggtgtagctggaagttgagcagatggtagtttgcatggatgagataaagccc/g/CL EC4M/"C-type lectin domain family 4, member M" 2654/18/rs321665/8622807/[g/a]/acatcaaaatatatgatgttttcctaaaataaaatgggggaaaagtttt taaaatacaga[a/g]tttccaaacaatcaatccctaagaattcacattgtaggtgatttacaaaaccatttgtca/g/R AB12/RAB12 2655/11/rs4943821/71491395/[t/c]/actgtatcgattaaatccttcattggccaattcaaaggccaccaact tccagagtcgtcc[t/c]ctggccctagactagcagcgaccttccttctgcaaccccagggactaagacgatacacga/c /C11orf59/chromosome 11 open reading frame 59 2656/11/rs2298457/71411859/[t/c]/gcagataccaggcattctggggaagagggatgttttcgattttctgc aatgacaacaacg[c/t]agaaaacagggtgaacttcctggaaaccatacctgagatcccagaacactgaaatctggg/c 20 /NUMA1/nuclear mitotic apparatus protein 1/ 2657/9/rs2280843/130624890/[t/c]/ccacgcttctcttccaggaagccatcctcatctccctggccgccctg cagcctggcctca[c/t]ccaggcgggtgcccggcacacctgaaagttctaaggggccgaggacatcagtgaagcagc/c /C9orf114/chromosome 9 open reading frame 114/ 2658/5/rs2879451/171567504/[t/c]/gaaccaatttcctcaataaaggacaggtactcacaagtcttgacagt aaagaccaacatg[c/t]gataggaatatgggcaaatagaacattcacagaaaaaaaaaatggccttaaaatatagta/c /LOC285588/hypothetical LOC285588/ 2659/3/rs7648605/186973428/[g/t]/ccttctctttcgcccttctaaatgtctgctctcaataatgtcatagc ctgggccatctat[t/g]aatgaatgggcagaagacttcatccctgcttcccaagctccaggatttaaatggtgtctg/t /IGF2BP2/insulin-like growth factor 2 mRNA binding protein 2/ 30 2660/1/rs2501618/178225432/[a/g]/aaattcgcaagatagaattcaggtttcacatacacactctgcaatat aagtcaacttttg[g/a]ttataaccaccaaagttctcaatgactgaaaagcattttctcctaaatggtaaagtatta/g /CEP350/centrosomal protein 350kDa/ 2661/1/rs6692753/173004080/[t/g]/aggaatgtcaggtgaccatcaggtaatggtcatgcagttgttaaact atctaacataatg[g/t]ttgtagcttgcgccagggaaaggctgtctcccaatagatagaaaccacctgaagctggtg/g /RABGAP1L/RAB GTPase activating protein 1-like/ 2662/15/rs2041849/34805649/[g/a]/aggtaaatattttaatggcatacccaaaattaggactgaaattttga agtatttgtttta[a/g]ctcttcacctgttttactcatatcactgcacttttcagtaacccctagacatcatacatc/g /C15orf41/chromosome 15 open reading frame 41/ 2663/3/rs33055/161086908/[t/c]/ttccgggccatttagcttcttttctgttgtaaggtgaatcaggaacaaa 40 catttcagaga[c/t]taaagaagaaaagtttcttggaattgcatgctcctaaaatttgacaatgattaaaaagtc/t/S CHIP1/schwannomin interacting protein 1/ 2664/16/rs8058694/16186364/[t/g]/tgtcgttctgtacctgtggaggcagggagggctttcctgggaccagg cgaaggtggcact[g/t]tgtatcgtgatgcaatccttcccggcagctgcagggcacaagaggccatttacaggagac/g /ABCC6/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 6" 2665/6/rs10499163/130004326/[c/t]/gaaaaacagtctcactgcaaagcagtgctctatcaccatctgcact cactagagaccaaa[t/c]gacaatgtggctaccacatcacagaagaaatttaaagggaggttagatggtttcaaagat/ t/ARHGAP18/Rho GTPase activating protein 18/ 2666/5/rs1364449/22511227/[t/c]/agtctatacttcaaatgaaaatgcatgcattttataattactaaagaa aaaataactaac[c/t]gattaataggaaatgatttaatataccctttctgggtctgtaatttatattttaggtgaa/t/ 50 (203) JP 2010-88432 A 2010.4.22 CDH12/"cadherin 12, type 2 (N-cadherin 2)"/ 2667/3/rs926147/8665221/[g/a]/tcaggaaggtcaccttccacctttccttttcctagccaatcctgaacctt tgtctcctca[a/g]cgacagcaaagccacactttagctggtgcccccccatcctgaagtctttctagaagcttc/a/C3 orf32/chromosome 3 open reading frame 32/ 2668/2/rs7571072/124557731/[a/g]/tgggtttatttccaagttctctttctttttcattgatttatgtgtcc ctctttctaccac[g/a]ttcacagtcttgattgctgtagacataagttttaaaattgagtagactaatttatccttt/g /CNTNAP5/contactin associated protein-like 5/ 2669/5/rs1994931/63539005/[g/a]/tcttgccaaactccctcttcatctctgaactccaatagtggcaatcta ttttagttccgg[g/a]gatccaccacagggcctttgaacacgctggtcctgaatcttggaatgttctcccacctgt/g/ RNF180/ring finger protein 180/ 10 2670/1/rs2501621/178211524/[c/t]/ttagatctatttctgagctctagatgcaagttttcagtctattagat gtctatcaccaag[t/c]accattggcacctcaaatttttcatgttcaaaaccaaataaattcattatctatcttcaa/t /CEP350/centrosomal protein 350kDa/ 2671/2/rs4268898/24343917/[c/t]/cacatttaccacatttacttacatgcccttcctactttcctttctacc tcccttcactga[c/t]ggacttggctggctggctgacttttcagacagggtcttactctgtcacccaggctactag/t/ ITSN2/intersectin 2/ 2672/2/rs3108779/173003543/[g/t]/aaatatcagatgcatgggacggtcagataaaagcacgatcatagaag acctatcataaat[g/t]tttgtagttcaaattttctatagtgcctttaactattcagtcacattttaaactccagtt/t /ITGA6/"integrin, alpha 6" 2673/7/rs1076237/99423377/[g/t]/agcaggaccaatgagaaaatcacatcacatttctatagcattttacag 20 ttaatactgttc[g/t]ctgtcgtgcttgacaaagagagatgattatttattagtttccacagattagacaatggcg/t/ LOC100128334/similar to hCG1770601 2674/2/rs718731/45685041/[g/a]/tgagccataagacaagatcagctactaacagggaggggagaggggaagg ggggtggagga[a/g]ggggagggcttagaattaagccttgagggattgcaacatttagagggtggtgagaagaga/a/S RBD1/S1 RNA binding domain 1 2675/9/rs2795492/99953197/[a/g]/acattctatatacagttgcacctccatgcctttgcttgtgcccttccc tttgccatttat[a/g]ccctccctatttatttggatgaacaaccatgagataatttgtggagttaatgaaaattta/g/ CORO2A/"coronin, actin binding protein, 2A" 2676/10/rs1412444/90992907/[a/g]/gctctttactgtccttcactcctattcaagagcaaggttgttgccac tggtgttatttcc[a/g]gtgtttaaaggcaaatagataaaaagaatggagaaggcctttcacacccaaagtgaaacg/g 30 /LIPA/lipase A 2677/17/rs3744124/17065540/[a/g]/ttggtccagatggagaagctcgctggtgaggcaggggtgctgttgcc ggggccttggccc[a/g]gatggccgtggggcggtaccagctgtctgctctcctggcaggaatcgctgagggagggaa/a /FLCN/folliculin 2678/18/rs650329/42533890/[t/c]/cacaaaaggggctcccagtccagagagtgggcatttgcccagctggcc tttgctcccagc[c/t]tctttcttggtctcagtactgggctcagcacagagctcccagtggcagaaaaatggggaa/c/ ST8SIA5/"ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5" 2679/12/rs7295280/50917133/[t/c]/agctgccaaggttcaagtctgggctgtgccacttagcagcttagtga cctgggcagatta[c/t]gctgcctctctgtgtctctgttcccttctctgataaccacagtaccatcgttataggttt/c /KRT7/keratin 7 40 2680/2/rs3811567/153280402/[t/c]/atttttaatgattattttttcaagaatgccaattgaagttgatggtc taagtaaatatta[c/t]ctgatacagcaacataactgattttggtagaccatgtaaataaatagaatctgaaaatag/c /PRPF40A/PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2681/22/rs174772/28105023/[c/a]/ctttgagtctctagaactccattctagaatcaggtaccagttctgaac tgatctataagc[a/c]gtaatgtgcggaaagatctgctgtgaagaaaaaaaagtgatgggcgcagtggctcatgcc/a/ AP1B1/"adaptor-related protein complex 1, beta 1 subunit" 2682/17/rs2429387/58120747/[c/t]/gcagcctgcgtgaggaaggcctgggtgtaggggtcgggcacgtaggc caggctggcattg[t/c]ggctctcacacagcaggagggcatcgtgccagcgcagcggcttctgaagcagccggaagg/t /MRC2/"mannose receptor, C type 2" 2683/17/rs8065903/45984457/[a/g]/aggcctcacaggagagtgcgtggctcgagtgggctctgcggctgcag 50 (204) JP 2010-88432 A 2010.4.22 gacacacaggaca[a/g]gctcttttgggactcccagggtggcggctacttctgcagtgaggctgagctgggggctgg/g /SPATA20/spermatogenesis associated 20 2684/15/rs10518683/50441415/[t/c]/ctgatttctcccatgattccttcttttccagaacatgttttatccc tttgtcaagactaa[c/t]gaccccatgattgacatgctggtttccctcccctctctggaattaatttatctttaaaca/ c/MYO5A/"myosin VA (heavy chain 12, myoxin)" 2685/14/rs11159169/75610342/[c/t]/tcttccactggcggctctgagaaggtgctctctgtcacattaatac cagatcactcatct[c/t]gggccttattgaagagagtggagagttcctcagcttccgttccttctagccactttattt/ t/C14orf179/chromosome 14 open reading frame 179 2686/12/rs11107257/92828284/[a/g]/attatgaatttacttttagacaatggtgtgcaaacctttccagttg caaaaaaaaaaaat[g/a]cctacagtaataccttcaagacactttaacaggtggggatttttgttagagatataaata/ 10 g/LOC100129881/hypothetical protein LOC100129881 2687/11/rs1573542/15152532/[g/a]/tctctagccaatgttacattcaagtgagagaacagtcaattttcaaa ataaatgagcaat[a/g]tatgtaatatgttgcaagtagcaaatgctaggaaggaaaagagaacagaaaaaaagacta/a /INSC/inscuteable homolog (Drosophila) 2688/9/rs1333123/9310563/[g/t]/tgtgagatcaggaggatagtagacgaaggatgggaagggtagttttcct cagagagtcgg[g/t]gtaaaggactggtgtgtactacagatgtaagtgaagtgtgaacagagaccaggaggactc/t/P TPRD/"protein tyrosine phosphatase, receptor type, D" 2689/9/rs10977579/9199799/[c/t]/agtgtttaaaattttcaatagaaaatatttaaaaatatatatcctgtc tcagattttacc[t/c]tacttgcaattagtaagttagcctaccatggtttcatggatgctgacagaagatatgaaa/t/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 20 2690/8/rs17818622/25944469/[g/a]/aactttatcggtgaatgcagtgagatgtagttctttaaagtaagagc tcctgcttagtgc[a/g]gagccattaaggtgtgtacttatgagaagcaaggtgcaggtgagtatttacagatttgca/a /EBF2/early B-cell factor 2 2691/8/rs9657371/4770066/[a/c]/catatttgaatatattatgacagaatgaactagcattataagtctttct gaatgtttagt[a/c]cctgagcagcagacacaaggaaggacaacatcactatggttaatcagagaataaaacatg/c/C SMD1/CUB and Sushi multiple domains 1 2692/5/rs1549924/107244108/[t/c]/caaagggccagtaagggggtatgtgggaatttgcatctccccataca tcagatgccactc[c/t]cagcacatgataagaagtggttccagaggtcctggtggaaggcctgtagaaccagccagg/c /FBXL17/F-box and leucine-rich repeat protein 17 2693/2/rs12693170/179445389/[c/a]/atacagctttttgttgtatataactattttacgaggcaaattcttt 30 atcacaaccaaagc[a/c]gaagatggttctgacatccaagcaagtccgaaatccctgcgcagaggcacagttcagctc/ a/CCDC141/coiled-coil domain containing 141 2694/1/rs10802343/244411391/[c/a]/ggctgtcagctgacatccctgccactccccacagctgagactattc agtaatggcagtac[a/c]tctgacatcctgtctgacatctagaggactcaggaaattcaaagaaaatactataaattc/ a/SMYD3/SET and MYND domain containing 3 2695/5/rs2366981/38414240/[a/g]/ctcacttgcgaacagggataagggaaatctattctgtggctctatgac aacatgtacccc[a/g]ggatcctcgcatgctgtaactggtctccaggcagatgggcaatgaaaaacacagcggccc/g/ EGFLAM/"EGF-like, fibronectin type III and laminin G domains" 2696/5/rs2460506/76182990/[a/c]/aggggaggctaattttgaagaagagcaaagtaggtgcaggaggtgagt tgggatctcatg[c/a]agtaattcaggccagaagtgacaagggcctgaactatggcgctagggttgaggaggaagg/c/ 40 S100Z/S100 calcium binding protein Z 2697/8/rs3915792/125757588/[a/g]/aatgaagaacttctaaggctaagtcgggcacatgaagcgtttgtgaa ggaataaaaaggt[a/g]ttgattaataatttgatttttaaaaattaatcataactcagaatgtgtaacaggactgtc/g /MTSS1/metastasis suppressor 1 2698/17/rs10512509/61412088/[c/t]/tggtggatgacaggagaggtagaggaggaccacttgtcagtctaaa agtgatggctaagg[t/c]tttactatacactccatgaacaaatggtgccaggaataattttttaagggataaaagctt/ t/CCDC46/coiled-coil domain containing 46 2699/17/rs2111413/61446775/[g/a]/ggaagccaggaagctcttccttaatggatggacagccagtgatctgc ccaaagaatgaac[g/a]gtggacaaacaatacacctaaaggatactgatgccttatacaggaagcaaggattatgaa/a /CCDC46/coiled-coil domain containing 46 50 (205) JP 2010-88432 A 2010.4.22 2700/9/rs4743173/99957423/[g/t]/tgtcatgtttattatatccttttccactctatagctcgcctttccttt tgctattttctt[t/g]aagggaaatttttattgctcaattttttttttttttttttttttgagatggagtctggct/g/ CORO2A/"coronin, actin binding protein, 2A" 2701/2/rs3769611/31982105/[c/t]/agaataatagcaaatcattctttgttggtggtaatggaatagtttcag tttctatgacca[t/c]gaaaagcctaaagaggaggtagcaaaagacatttgagaagattagaatatattttatcag/c/ MEMO1/mediator of cell motility 1 2702/21/rs2834645/35109556/[c/t]/atgtaattctgctaggagaatgctggggaggggagggactggggaag gttccttggcttt[t/c]gtagttgctgtggaggaagcaccaagtgaagccagcaggatggcagcactgaaacgctcc/t /RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncog ene) 10 2703/19/rs2965292/841844/[c/t]/caggtgcccggcccactgccttgaagggactcggtctctcaggccacct ctcactcaccc[c/t]ggccctcctctgtaacttgtgtgagagcctcagcctcctgggggtacagagggtggattc/t/M ED16/mediator complex subunit 16 2704/12/rs4761533/92826085/[c/a]/ttggtaaacatatacatggtgaacaatacatgatatacacatacatt attactgtcaagc[a/c]aattaacatacccatcatctcatatagttacctttctttttgtgtgataagagtctccaa/a /LOC100129881/hypothetical protein LOC100129881 2705/12/rs10506454/61553115/[a/g]/aatactacttttttaatttctattttataataaggaagcaaaaaaa cagaggttaaatgt[g/a]tttctaaggccacagacctggttagtggcagggttaggactctattttgatataactcat/ g/PPM1H/protein phosphatase 1H (PP2C domain containing) 2706/12/rs3890733/46575640/[t/c]/gggtaccttctagtacgttagtaaggaattctacaggaacagggttt 20 ttcctatcccact[c/t]tataacagttacctgttaaaaaaaaactaccagaggatgcagtggagcctgcagggcaga/c /VDR/"vitamin D (1,25- dihydroxyvitamin D3) receptor" 2707/9/rs2787348/116161661/[a/c]/actgtgaagcgctgtcttattcactctgacagtgatcatccctgtgg ttttagggtggaa[a/c]caaacattctgcaggaaaggctcagtgacttactccaggggagccccatgacttttctca/c /AKNA/AT-hook transcription factor 2708/8/rs9297788/130486953/[t/c]/ttatttacgtagaatgttttaactttattttacagtaacttttacac aggcaaaatgaat[c/t]tagtacaaaatgaaacagttgctagagaagagggtggaaggagaggggaactagcaatct/c /CCDC26/coiled-coil domain containing 26 2709/6/rs11751090/118111891/[g/t]/ctagtaggtagattaggcaaattaacttctactctactctgttttc ttctaatccatatg[g/t]gtggcttctcctctgttgtacttccaaatgttgtggtgtcctagagtttggagctgtatg/ 30 t/NUS1/nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2710/6/rs17197845/21867715/[a/g]/ccactgcacccggcctatgagcctttttaaaaataaacaagctgact gtttttaccaaac[g/a]ctatgaaaatacaattataagctattctgtcaattaggaattagaggttcttagaccata/g /FLJ22536/hypothetical locus LOC401237 2711/5/rs4958532/151752045/[a/g]/gacatctgttcactagagagggctgttgggaggtgagagttgtgcat ggatgactgacat[a/g]ggaattggggacctatatcttcggtcagctccacaaagtggcattctgtcaggaagatgt/g /NMUR2/neuromedin U receptor 2 2712/5/rs10513170/14316981/[c/t]/cagcctcagaggcatccctgacaggctttacagggacatgcacagac aggtagacgaatg[t/c]gttctttattctggcattaggcaaacaggatcagttttctctgtgcatagctctgtgctt/t /TRIO/triple functional domain (PTPRF interacting) 40 2713/2/rs2974134/80033757/[t/c]/aggaagagtggtgttggagaagggctctgaaggacagaggggatggaa gtgagaattgaa[t/c]gtcagcagaaggacccacatgcctcgatgtcaatcgctgtgcttgaattaacaaaaactc/c/ CTNNA2/"catenin (cadherin-associated protein), alpha 2" 2714/1/rs6661744/173923662/[t/c]/gttagcgccccccaccacaccctcccctcccccagaatacgctccaa tcttccagcaagc[t/c]gggcgtgaatacaccagccatctcaaacacccagggatttggggaaagtgttaagaagga/c /TNR/"tenascin R (restrictin, janusin)" 2715/1/rs7554034/163877088/[a/g]/agcaaaactttgtctcaaaacaaaaaaagagttcccactccctgaag ctgttttttgttt[g/a]catgtttgttgtcagtctcctgtcatcattcgaaggtcagggccttgagggcaggaccct/g /MGST3/microsomal glutathione S-transferase 3 2716/18/rs645860/75437466/[c/t]/tcttcctcttgtcagccggccaaggcccacggaggtagctttgtttgg 50 (206) JP 2010-88432 A 2010.4.22 gcggccgtctcg[c/t]ggagctgtgtgagcacagctgtggagcgggcagagtcacgggcttggatttttcaccctc/c/ LOC100127987/similar to hCG1645807 2717/7/rs6972578/24950318/[g/a]/tattagggagaaaccaaagattaaaagttatcttgacttgaagagatt actggattcttc[a/g]tattctaaaataagatgtctggttacaatagtggctgtaacacctcctaaagttattgtg/a/ OSBPL3/oxysterol binding protein-like 3 2718/6/rs2757594/7535623/[t/c]/gctgccggacgttggaggaggtgaccgcgtccctgggctgggacctaga tagtctggatc[c/t]cggggaagaggaggcggcggaggtgaggagcgcggccgcggggccctttcggggactatc/c/C 6orf151/chromosome 6 open reading frame 151 2719/2/rs10185359/144872201/[t/c]/aaagcaaatgtgcttagagtacagtgatccactgtttcatccattg ttctagcccactga[c/t]ggttttaggttcatgttaaagcaaactcttctgtttctgctgagttttttcactaagatt/ 10 c/ZEB2/zinc finger E-box binding homeobox 2 2720/1/rs4506523/232147495/[t/c]/tggatttttgttgttctgttcataattgaaaatccatacaaggagaa gagaattttcatt[t/c]ggttagtgatcatgttgtgagccctgacgtcaaccagaaaaggtgattcaaaatcaatat/c /SLC35F3/"solute carrier family 35, member F3"/ 2721/10/rs606289/6601253/[a/c]/acaaaaatatgtgctggaatagcctgcctcaggactaagctgtgtgatc tgtcctctgtg[c/a]actctaaatttcagtcggtctcatcttcactctccattcacgtgtgatctgagagaccaa/a/P RKCQ/"protein kinase C, theta"/ 2722/10/rs586355/6598194/[a/c]/ctctcttgtggagtcaaagaacactggtatttagcatactggagatccc ttttgtcttag[a/c]tagatgaggtattacaggcccaagatctccaggtatgttactgattctccttccaggtct/a/P RKCQ/"protein kinase C, theta"/ 20 2723/10/rs563798/6592858/[a/g]/gtagccgatgactggctcagaactcccatgtcaatctgagggtgtgatt acactggcctc[a/g]ggtcaccaggctccctaccacttcctactggtgatttgataatggcgatggttattcttt/a/P RKCQ/"protein kinase C, theta"/ 2724/18/rs4940675/54198006/[g/a]/ggaatttgaagagtggtcattgcttctcatgaaagtgtcgccgtaac tcatgaaagtgtc[a/g]cctgtaacgaatcctagagggatgcatttctgtaccacggagggctcgagccgagacacc/a /NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" / 2725/7/rs2299268/95457009/[t/c]/taacagaaactctaccatggagagaccacatttattttcccctatttt tgtgtgacctgc[t/c]tacctacgctgtggggaagaggtttgcaattttgaaaaatgtgttgtatatgaggcgtaa/c/ DYNC1I1/"dynein, cytoplasmic 1, intermediate chain 1"/ 30 2726/5/rs6868410/106777589/[g/a]/attataccaacattcacatcacaaagactgccatttctcaagactga tggtactgttgac[a/g]tgacccttccatttaatcaaatcctctagtacccacttctttcaagtcttgaattcagac/a /EFNA5/ephrin-A5/ 2727/10/rs7904732/68881735/[g/a]/atccaaacaggttaagtaatcccatacacaatgtacaatgatccgtg ttgtgataactac[a/g]tgcaaacacatagttagagttccgaaggaaataaggaaggaagaataggaagagggagaa/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 2728/9/rs2567698/115877766/[c/t]/agggatacatgagagagcaagacagaccccattccctggggttcctg gagcttgcaattg[c/t]gtgggtcaggcaggcaggtgagaggcagatgcaatcagtgtgagaagtaccacatggggg/t /AMBP/alpha-1-microglobulin/bikunin precursor 2729/2/rs3792009/43890837/[t/c]/tgtgcatctcctatttcaggtgcttcttgcgcctcactgttaagagta 40 aaattttgacat[t/c]tgtgaacccaattccggtttcctcccagctacagctgagaatgccttttagaaagaatgt/c/ DYNC2LI1/"dynein, cytoplasmic 2, light intermediate chain 1"/ 2730/10/rs1660627/34510310/[c/t]/gggaagctatgatccagttaacaaaagttgggtttgtaaatcactgt tcaaaaatacgta[c/t]ctgtataacgaccagtttgcaagttgaaaagcattcatatgcaaaaactcagagggatga/t /PARD3/par-3 partitioning defective 3 homolog (C. elegans)/ 2731/15/rs2289181/46877467/[a/g]/atacaagtgaaagtgacttcaggtgcttactgtccgtctgtgccatc ctcgctgcagtcc[a/g]aatactggagctctggagaggagaggtcgtcatccagcatgtcatggggaaggtctgtga/g /CEP152/centrosomal protein 152kDa/ 2732/15/rs8037958/47066698/[g/a]/caaaaccatagcacaccagatcacaattccattctttggttggttcc tcagcaattacat[a/g]aagaacatcatgctcagccagaagctccaaatttcatgcagctcattatcttatttgctc/g 50 (207) JP 2010-88432 A 2010.4.22 /KIAA0256/KIAA0256 gene product/ 2733/1/rs6540923/214200918/[g/a]/tctttcctgcctcatgcacttgagaataacttggctaagtttgtctg ccttagctttttt[a/g]tttgtaaattctgtcaggacagagattcttcaggtccaacctttgttgccattttacaca/a /USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 2734/2/rs4254462/152928082/[c/t]/tgaaaaccttttgtttcaagtttctagatgtttggattataactaaa tggaaactggtca[c/t]attaaactccttatgtgttgttagtttgtttcctgaaaatcttagtttaaatcccaatgt/t /FMNL2/formin-like 2/ 2735/2/rs1370701/216846134/[g/a]/atcgttaacaatgtatttacctttccttttggagcggtgtgctgagg gacagctcatgaa[a/g]gtaggagggactccaaggagaagcttcacgaaagccaactgcagctctgcagatacgccc/a /4-Mar/membrane-associated ring finger (C3HC4) 4/ 10 2736/4/rs6817487/23060335/[c/t]/atatacaaacacaactgattgttcctttatgacatacactgcatccgc acttattacttc[t/c]attaacttattggtggagtcaacatactttctgcataaatgatcatgtcaactgtgaata/t/ LOC643751/similar to cell division cycle 42 2737/7/rs10486792/16250664/[t/c]/gtttaagtggtagaaatttgtttcagcatacaatactgatgaaacct ccattgtctctta[c/t]gttctcaagtatataaaaatactttggaattccctggtatctgtcattcaatagatattc/c /hCG_1745121/notch1-induced protein 2738/17/rs1545283/30769561/[t/c]/caagaccaacccttctcttcctcagcctacacaacgtgaaggcaatg agtacgaagacct[c/t]taaatgatccatttacacctaatttatagaaaatatatttcctcttccttatgactttct/c /SLFN12/schlafen family member 12 2739/19/rs830145/52645983/[t/c]/aattgatacaggggaagcacccagaggcacagttagctagtgatatcc 20 acatattaatat[c/t]ataatcttagagtcctaaaagtcatgggatatgagacatttacatgtaagggataaaggg/c/ SLC8A2/"solute carrier family 8 (sodium-calcium exchanger), member 2" 2740/1/rs3795686/26454678/[t/c]/gccccgctgcccggtgccttcttggcctcaggcaacactctgtacaac tccttacttgtg[c/t]tggttcttgggttgtggaagcggactcggtggtgaggatctgaataaagtgtctccatca/t/ CCDC21/coiled-coil domain containing 21 2741/1/rs1851736/77519836/[t/g]/tgaagggttggattccacaccatgatccccttttcccccttccccaca gctccctatagt[g/t]aaagatccgtaaccttaggaataaatgataaatcctgtgactattaggtttttcctggga/t/ AK5/adenylate kinase 5 2742/7/rs4724573/47398036/[t/c]/gcccagtctcactgagtctcaaagtctcaaagaggaaagtcaagggta tgagccctgtcc[c/t]gcacggtctcgagcacaagacacactctgagccacagctgccatcgccgacagtgtacgc/t/ 30 TNS3/tensin 3 2743/1/rs6701500/15936285/[t/g]/acttctcttcccgcatggcctcatgtacgataagaataaaagctaccc ttgagggcctcc[g/t]cctcgtgtgcactctgcaggggggcctcagggccacccaaaacaaataaaaaattaaaaa/t/ SLC25A34/"solute carrier family 25, member 34" 2744/4/rs7674434/39095804/[g/t]/ttattgcatacatactgtaatatcagaaacatactaggtacctgtaat atattatctcat[t/g]taattcactcatcagctttgccaggtaggtgttctgaaactcaacttacaattgatgaaa/g/ KLB/klotho beta 2745/5/rs10515449/112268058/[t/c]/taaaaatttgtttcctgtacattcattctgggcagaggagatacgt aattacatttcact[c/t]aaggtcttagttttgtgaacgcaatagctcacaactatgtacttccaaaagaagcaactc/ t/REEP5/receptor accessory protein 5 40 2746/17/rs11869485/3347986/[t/c]/caaaatccccagatgatttacaagcacctcaaagtttgagaagaact gttctggggttcc[c/t]gtggtgtgacagccatggtgcttgagggctcaaaggtccaaatccctggtgcgggaccct/t /ASPA/aspartoacylase (Canavan disease) 2747/19/rs2302524/48848312/[c/t]/gggcctcggcagtcaatgaggaaagtctcttcagaggagcatccatg ggtgctgttcccc[t/c]tgcagctgtaacactggcggccattctgcggcagattttcaagctccaggacttaggaga/c /PLAUR/"plasminogen activator, urokinase receptor" 2748/8/rs4735521/99077191/[c/t]/actttcatactcattctagcaagtgctaaactgtgtatagtggcagat ggttgcaaatcc[c/t]ggattttgaaacggagcctgtcttataaaactattctcactgccttgtgagggtacaaac/c/ MATN2/matrilin 2 2749/12/rs1861918/31002885/[t/c]/tgttcagacctggtctcccagtcctctccctgagcccccatgctgtg 50 (208) JP 2010-88432 A 2010.4.22 tttgctccccaaa[c/t]tagacccattcacttctccgtcatagcagaagtcactctggtggttactaagtcaggtct/t /TSPAN11/tetraspanin 11 2750/1/rs7314/171724222/[t/c]/tttatagcaaaatatttaaaggtctctttccctgctcttcacttatctac taggaaggta[c/t]agaattaaaaagctttttttcccccagctgtgatcaagatgtattaaaagaatatgaaag/t/PR DX6/peroxiredoxin 6 2751/11/rs7946913/100108524/[a/g]/ttcatgtctggcttggaagattttcttctctagatcttcaagcata tcaactgacttctc[g/a]ggtggagccttattctaaagcacaacacaggaaagtcctggacaagattgataggtcctg/ g/FLJ32810/hypothetical protein FLJ32810 2752/4/rs3796720/68297542/[a/g]/tttattgaatttaaaccgttggccaatgtcagtagtgcattctacacc agtaaattctct[a/g]tgtgttaaggcaagcctccacacatcttcagacaacatatctttacactaaggactaagg/g/ 10 GNRHR/gonadotropin-releasing hormone receptor 2753/3/rs2134655/115340891/[a/g]/tttagctaaattggagacacaaatctgacaccgactttggaatctgc taattttggctgc[a/g]ctttgaaggtaggaaatccaatctcaagaaaacattgatagttgcctctagagcctgcct/g /DRD3/dopamine receptor D3 2754/10/rs1530064/132938782/[g/t]/agaccctccacagggaacggtggccggtatatcctacttggggaat ctcattccacgaac[g/t]cagggaatcctgaggagacacacatgggttgtgaaccgagtcctggctgtcactcatcgc/ t/TCERG1L/transcription elongation regulator 1-like 2755/11/rs4757989/7258982/[c/a]/atccctgcttttatgcaggagcatatgtatgatactcaggcacatttc tatatttgcata[c/a]aaatgcagctcctctaaaccagagcataacagtatcatgtctgacaaatgtgtcctgccc/a/ SYT9/synaptotagmin IX 20 2756/11/rs1487884/7259420/[g/a]/cagatagtctcaaactttcagctccaaaaatttttacacatcaaataa attctatatctg[a/g]ctttgtgtaaatggctccaaaaatctactctcatggccacagctaggctgccatcgaatt/a/ SYT9/synaptotagmin IX 2757/12/rs822872/29548967/[t/c]/aactcatgtcttaaaaatttaatgggaaaagactgagccccaaatttt gaatagtgatta[c/t]gccttacttgaagtgctaataaaggtaggagagtacatttgttggaataacagaaatggt/c/ TMTC1/transmembrane and tetratricopeptide repeat containing 1 2758/22/rs741413/18666099/[c/a]/gaccactaggccccctcggaacctgtgcagccctgtggttcttccctt cccttgccaccc[a/c]acaagagtccgctggccacaccgcctcccctgcaggcccggcctcagtgccgcccgcccg/a/ LOC440792/proline dehydrogenase (oxidase) 1 pseudogene 2759/1/rs2492301/37711760/[c/t]/acacacacgcacgcacacacacacacacacataggaagccaggctccc 30 ctctgccctcag[c/t]cactcgtggttcacaaaaatggcaaataataggagcactagaataggagctctccatcct/t/ LOC728431/hypothetical protein LOC728431 2760/1/rs4654770/22019664/[a/g]/aaaaaaaaaaaaaaaaaagaaaagaaaagaaaagcggcagccctgccc ccaccaacatgc[a/g]taatttttctcactagcatctatctcctttagacataaattctattcatgtgttttgttt/a/ LDLRAD2/low density lipoprotein receptor class A domain containing 2 2761/1/rs6684152/22020351/[g/a]/gtacaccctcttccttgggaagtagctccactcatagaccttaggccc tggagccagacc[a/g]tgtgagttcaagtcctcctatcacttccagctaattgaactcggcaagtgacaacctctc/g/ LDLRAD2/low density lipoprotein receptor class A domain containing 2 2762/1/rs3736360/22022707/[a/g]/gtgaggagctggtcagcggccggtccccaggtcccaacgtggcagtca acgccaagggca[a/g]cgtctacatcggtaagtctggggctccttctcagggcaggggcaggaacggcactccctt/a/ 40 HSPG2/heparan sulfate proteoglycan 2 2763/4/rs7655494/169669901/[c/t]/aagccgcaaagccaagaaacagaagcccaaatggggagtcctcgtca ccagacagtgggtacctgtctcctaaaaatcagccgtcagccctgctgagtgcctcagccagccagagcccta[ca/tg] gaagaccaaggggagatggaaagagaggtcaagtcccctggggccaggcattgctaccaggacaaccaggacttggcagt gccacacaaccgcaagtctcacccacagccccacagcgcc/c/PALLD/palladin 2764/14/rs943164/33337171/[g/a]/ttaatggcatcgatcaatgcctctttcagggtgctggactgttactta tttcctgaatct[a/g]tgcagaacaaacgcatgcattttcatttcctttggggaagcggacttcctgagtagttct/g/ NPAS3/neuronal PAS domain protein 3 2765/17/rs2294914/18129609/[a/g]/ataggctgtccaggcaaaggagggattccggggtgagcaaggtgccc atgcgccacccgg[g/a]tggagctgttgtctgtattacctcagagtaaccagcaagtggcttccaggtacggatgcc/a 50 (209) JP 2010-88432 A 2010.4.22 /TOP3A/topoisomerase (DNA) III alpha 2766/17/rs2273026/18197704/[a/g]/ggccctaggctcttgcttaaataacaaatactctgaggggtacccgg gccagaggtatgt[a/g]aatatcttcaaaggcctggttctgacacagtcatagggagtactcagtcagcctaggacc/a /SHMT1/serine hydroxymethyltransferase 1 (soluble) 2767/9/rs4430151/93702295/[g/a]/cagggctccagataagcctccctccagtgctgggcaggcccccagata agctcaggatgc[g/a]gcgggtcccccagggccgccagggggtggggggcagggccccagcagcctcgcatccaga/a/ ROR2/receptor tyrosine kinase-like orphan receptor 2 2768/10/rs303436/30771899/[c/a]/atcaccctgttcatcatctccaataattggtagaacattttggtatgt tcttgaaaatct[c/a]ctgtgacaaggagctcattacacactgggacacaaagtttcctatttgtccagtcctgac/c/ MAP3K8/mitogen-activated protein kinase kinase kinase 8/ 10 2769/5/rs2277945/169466184/[c/t]/tttgagtgtggggggtgtccccaaggaagactcacttccttcctccc caagaccccattc[c/t]agaaagttctgactagggctgtgccccccaagactgggggatgctaccaggcaggacaga/c /FOXI1/forkhead box I1/ 2770/18/rs12457694/32451248/[t/c]/atgcttgtgtcctttccccagaaacatctttcttgtaagatgagtg aaaggatcatcagc[c/t]agatgctttagctccttcttctcagtctgcccctaaacaatgtattattgaattttgtct/ t/FHOD3/formin homology 2 domain containing 3/ 2771/1/rs10912807/172782989/[t/c]/cattcttgatcttgctagctgtgatgtttctttgtgtgtaaaaagt taggggtataatta[t/c]agtagccttttcctgctaccacctggcatttagcagaccagttctcagtgaatgtgagcg/ t/RABGAP1L/RAB GTPase activating protein 1-like/ 2772/7/rs12673082/107798557/[t/c]/taaaatacagcatctttcataactgcttcttcacaccttacagaat 20 tcatatatacttgc[c/t]gtcatattaataatatttctccaaccaggttctacttacatctgcctccaaaatttgctc/ c/NRCAM/neuronal cell adhesion molecule/ 2773/15/rs2733333/55223218/[a/g]/tttattcacatgtgcattgcctatacacatgagtgtacccagagacg agttactcaaaag[a/g]ctgtttaaaatttggagtttgtatacctaacttggtagaagaaagagagggaaaagtcag/g /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 2774/18/rs8085882/20997897/[g/a]/ctgctggtttgggtttacagaaaagctgtcctttcactataaatgat aggaaggtcccag[a/g]aggagtatgtgagaaagacaggggcagaaggagaggacagatcgaaatgtaatgcctgag/a /ZNF521/zinc finger protein 521/ 2775/8/rs4871440/125017091/[c/a]/cagaccctgctggtgatcaggagacacatgggttcagggaagtgcaa 30 gctcctgaacacc[a/c]gctcaacacagctcctggcagtatccatggtgatggaagacagaaagcatatggtaatta/c /FER1L6/fer-1-like 6 (C. elegans)/ 2776/5/rs1477280/160051326/[c/t]/tagtctctgaagagcttcctgcaggcttggggtctgtggactgaaaa tcagttggattga[c/t]gaaagctatgagaagaattatgatgagggtcagatcatatgggcatcaggaaagtaaaat/c /ATP10B/"ATPase, class V, type 10B"/ 2777/4/rs10520393/178999588/[t/c]/gaaagcactattgttctcagttgcattgcttttcttcattgttggg tacctgtttttcca[c/t]ggttgttatgcacacataacttactcctttttaattattttggccttttgttgagatcac/ t/LOC285501/hypothetical protein LOC285501/ 2778/2/rs735315/51184661/[g/a]/catggccaaatcctgcccattgcctgatattataaaagttccactagaa ctcaaccatac[a/g]tatttattttcatattgcctatggctgctttcctgtgacaacctgagttgagtagttgcc/g/L 40 OC730100/hypothetical protein LOC730100/ 2779/2/rs17751491/187442394/[t/g]/caatatggccttaggtgttaattcagaggcatcatctaacccaaaa tgagaggctaaaat[g/t]cttcttttaacaagattaagtactagagaataactattgtaagaaaatacttactaattt/ g/SHROOM2/NA/ 2780/12/rs836964/48556162/[c/t]/gtaagttatctgaggtctgagccaagatttgaacccaggtctgtgtga ctccccagccta[t/c]gttcttaagcactgtattatactggactcatgccctttctcgtatgaccacacatggctc/c/ FAIM2/Fas apoptotic inhibitory molecule 2/ 2781/10/rs10509928/112462093/[a/c]/atgtttgattgtgtggttgtgtatagcagtagcaataatagtggt ggtatcagtagtaat[c/a]attgtgaacagagatgattcttttaaaattaaaagctactgcaatttaatagctactgcc /a/RBM20/RNA binding motif protein 20/ 50 (210) JP 2010-88432 A 2010.4.22 2782/5/rs2968294/63548192/[g/a]/ggatttccaactttcacttgaagtttttaataaatgtttgtaagctag acatctttcagt[a/g]atctatgccatgacagaaagtattaatgacagtacagaaagttatttaaatatttgaatc/g/ RNF180/ring finger protein 180/ 2783/9/rs12339991/125550906/[a/g]/gctggcttgcagggaggtccaagaaaaattgttgacactcaaactc aatcaaaaagcacc[g/a]aggagcctctcctgtagaatgctttttcatctcccaaaaagggtccctcatgtcgaattc/ g/DENND1A/DENN/MADD domain containing 1A 2784/8/rs6984344/124777648/[a/g]/tgtttagcaggtggaatactgtacctatcattccttgacttagtttt tctctcaataata[g/a]tatcccggagatccagctatgcttgtacatggatagtcacctagagttttttaaagggac/g /ANXA13/annexin A13 2785/7/rs2242493/142738658/[c/t]/catctcttggacataactactgcagggaaacaaataccaggcttctg 10 cctttcctatctg[t/c]ccacatccccccagcaatgtactctatctgtgccaaccgcaccttctttctagcttgggt/t /CLCN1/chloride channel 1 2786/6/rs756487/110781805/[c/t]/aaatcatgaagaccatatctagtcctctataaatcccttcaaaaagaa ctttatctgtaa[c/t]catagtaaaggtctgtttcatttaagaaagaaaaaaaacccaaacagaaacacatgcaga/t/ C6orf186/chromosome 6 open reading frame 186 2787/9/rs4240705/136451221/[g/a]/ggcctgggtccaacttccagaaccgctcactgggccccttctctcag atgggcaaactga[a/g]gtccagagagggggcgacctgcccagcgtcacggtcctggtgcctggtttctccccagcg/a /RXRA/"retinoid X receptor, alpha" 2788/6/rs4712802/10750245/[t/g]/ttctcctctgtgattggatttctgacattttatctaatgtctatttct cttcatatccag[g/t]ttgggaatccttttagaaaaggctcagtcatattcagtgcccttaattccttatacacgg/g/ 20 GCNT6/glucosaminyl (N-acetyl) transferase 6 2789/20/rs6031245/41992945/[t/c]/cggtgcagattcaagggcagtgtttgacactttgccttcttaatact caaggcttgcaaa[c/t]tgcactgccctaccatggttttctggaagccccttacccatcgctttctttctacctatt/t /TOX2/TOX high mobility group box family member 2 2790/4/rs11929713/110652299/[g/a]/acaaagacaaaggtatttgtatatggtatgtttctctctcactgtt atttctaaagttaa[a/g]ctgataagatctcacttacattattttcttggccaatgtttgttatgactttattttagt/ a/SEC24B/"SEC24 related gene family, member B (S. cerevisiae)" 2791/3/rs2365054/61044854/[c/a]/caactggaatttatttctgtttatgatgtgaggttcatttttccctgc cctgatacccaa[a/c]tgattcagcactatttaatgaaaagatcgccctttcttcattgctccacagtgtcatctt/c/ FHIT/fragile histidine triad gene 30 2792/18/rs2127958/16907608/[c/t]/acactattataagaaacattcatttttaggtaaattttcaaaaccta aatggttattatt[c/t]taaacctaacagacatatttttggagaaacaccaccccaccctcaaaatccattgaaaac/c /ROCK1/"Rho-associated, coiled-coil containing protein kinase 1" 2793/18/rs1943177/38631842/[c/t]/aatcagccaagaacagtggcatgtttccctttatttgtccaccttct tgtaagcattgta[c/t]gtcttatattcccttgtatgccttgccatttcagtattttctaaaacatttaaatttgcc/c /RIT2/Ras-like without CAAX 2 2794/18/rs622364/38591297/[c/a]/cttcatcaaagtcatctgctactctggtccctagattccattcaagaa ggcatgatgacc[a/c]ggtcttcttatttttctgtccagagattctgcagggccatgttctaacctgacaacatat/c/ RIT2/Ras-like without CAAX 2 2795/7/rs10264489/32805791/[c/t]/tacactatataacattgctgagagagatttaaaaagatctgaagaga 40 gaaatataccatg[t/c]tcatagtttggaggagttgatattggtaagttggtaattctctccaaattggtctgcaga/t /LOC100128208/similar to hCG1645499 2796/19/rs4807546/4133060/[c/t]/agggggcagccgatccctccacttcccctctgagtggctggagggatc tttctggcacat[t/c]ctgtccagtcccctcgccagggcaaaacccttccccatcaccctcaggataaagtgccaa/c/ SIRT6/sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevi siae) 2797/18/rs11660303/17668757/[t/g]/gtctgggaaactgtcacaaccaaagggagctaaggagaaaagacaa ctaaatgtaaaggg[g/t]tattctggaacagagaaagaacattgaataaaactaaggaaatctcaggtgtggactttg/ t/MIB1/mindbomb homolog 1 (Drosophila) 2798/3/rs4353759/24487960/[c/a]/gcttatcagtgcatactaaattaataattgatagtcttttagaatttg 50 (211) JP 2010-88432 A 2010.4.22 ggcctccaacat[c/a]tatctaatgcaatgttgtggttttaaatcctttttcaggccttcttgatttggacccacc/c/ THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on cogene homolog 2, avian)" 2799/9/rs7037313/133154314/[t/c]/gcacacctgtgaccacttacacgtgtccttctttccatccccactga gctgtgagctttt[c/t]gcagtgcgcccagcactgacacactgccaggcgctcggaaactatttacgggttgcctga/t /PPAPDC3/phosphatidic acid phosphatase type 2 domain containing 3 2800/10/rs4948503/63510068/[c/t]/actcggcacactattttttctgctccactcaagttcacaccataaaa tggagatcttctg[c/t]ggctcacatctctctcagatggagcttagcttttactgtgctcaaccagggttgtgcccg/c /ARID5B/AT rich interactive domain 5B (MRF1-like) 2801/6/rs1410826/46889141/[c/t]/tagcagaatgaataagaattcaccaaccaagtttctgctgtcttcaga 10 attgtctatttg[c/t]actctttcagacttttgatgtaggcatttaatgctgtggaactttcctcttagcaccact/c/ MEP1A/"meprin A, alpha (PABA peptide hydrolase)" 2802/6/rs2608897/131935156/[a/g]/tttagtctctgccattctgaatccacttaaccgtcgagcttatagtc taaatgctgggaa[a/g]gtgtcaacctctatgcccctgagctaccatttgtcaccatacaaaagtatgaatttaaaa/g /ARG1/"arginase, liver" 2803/12/rs2261612/119234622/[g/a]/atggttggagatgaaacgtctctgacagctttgtgcctcccaaggg catactgttcagtc[a/g]gcgtcttccttggttccagggtcctgtgcttggattgtggggaacagactccccgggggg/ a/SIRT4/sirtuin (silent mating type information regulation 2 homolog) 4 (S. cere visiae) 2804/3/rs4677213/73077284/[a/g]/ctagcatatattatgtcaggcatgggccaggcacacagactttagatg 20 ttacctagatac[a/g]gaagatcccagccctcaaggggtttctattctagttagaggaggcaagcaacagatgaga/g/ GLT8D4/glycosyltransferase 8 domain containing 4 2805/9/rs9650702/32451331/[a/g]/agcagatttaccctaaaagaatggctaaaagaagttttctaaacagag gaaatgataaaa[g/a]gaaccctgaagcctcatgaaggaagaaagaacacactgatttcctccatgtcttctatgg/g/ DDX58/DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 2806/10/rs7350385/68685813/[c/a]/aatagatatagagtatatataacagataaaagagacaataagaacag cagcaaaaaaaaa[a/c]ggatttctctcctttaaaattcttagacccttaaattatattattttctctatcaccaaa/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 2807/10/rs1904607/68691190/[g/t]/aattaaccatgaaatgtgaaaaatatatgaatggtcttcaaaaacaa catttgggaaact[g/t]tatgtcagaaataccaacactgtggttgccaagagtgaggcattttgcgatgactaacaa/t 30 /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 2808/14/rs10140652/19761728/[a/c]/tacttagtacatcatccagcatgagttagcaaaatctccaaatgtt ctttattattcatt[c/a]tttggttacttctgtttttctaacagctttgggaccccagaacagaacaatgcattttgt/ c/OR11H6/"olfactory receptor, family 11, subfamily H, member 6" 2809/14/rs731897/20096132/[g/a]/agtgctaaaacggaatttgagcccctagagtgctttgacaaattggtc catgctccatga[a/g]gaaccaattatttaattgcagaagcaacctcctgagttttcttaccttaccaggctcgtt/a/ RNASE9/"ribonuclease, RNase A family, 9 (non-active)" 2810/12/rs2283275/2054821/[t/c]/actctatcttgtttaatcttcccctcccattgatgaagtggggacctc ttacattttaca[c/t]tttagagaaaattttacatttatggaaacccattttacagagaagaaacctgacgttccc/c/ CACNA1C/"calcium channel, voltage-dependent, L type, alpha 1C subunit" 40 2811/8/rs2926703/71329548/[t/c]/agtgtattcacactgttatacagctatcaacaacatccatcttcacaa ttttttcatctt[t/c]ctttacccgttaaacactctacccattaaactcttaactccccattcctacctgccccca/c/ NCOA2/nuclear receptor coactivator 2 2812/8/rs2958367/71327441/[t/c]/tcccaaatagagtcaaaagaaagtgacaatcacatacgttagggccct gaagaaacctgg[c/t]tcctcaatgcatcaagtattacacaggtcattggtattaaggtttttatgtctttttttg/c/ NCOA2/nuclear receptor coactivator 2 2813/2/rs1898003/11622287/[a/c]/tgaaaatggactaatacagggcagttccttgcattggcttgggaaagg gaggtcaattcc[a/c]tgaggtcaaggtcaatccccagggggtcccctaactctctgacctaggtccctcccagcc/c/ GREB1/GREB1 protein 2814/1/rs2275568/235082251/[g/a]/tcttgttactagacatagaccaaagcttgccgtattacagtattaca 50 (212) JP 2010-88432 A 2010.4.22 aaggcgctgcttc[a/g]taagtagtttttcctactagactccaatctccctaaggagaacacgcgcgtacacacaca/a /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 2815/14/rs7157032/99254776/[t/g]/ggtttccttaaatacaaacaggctccctctgggacagttgcatggag tggctgaagcaag[g/t]gtcaaagctctctgaatgcaccaacaggctgggtgggagctctggggaggtggggtcagg/g /CYP46A1/"cytochrome P450, family 46, subfamily A, polypeptide 1" 2816/4/rs1991219/110220124/[t/g]/ctaggtactgtgctaagtcctgagatgaaaagctgaaaaataacaca tcgcccttatcca[g/t]gtgaggatttcagtatgtacacagagatatacaaacacctataataagagctagaataaa/g /COL25A1/"collagen, type XXV, alpha 1"/ 2817/3/rs7636169/135194886/[t/g]/tcctgcttccgttgttttgtgttgtgtttcttttctaatggtgccct gttcaaagctcag[g/t]agtaggaatggagcatgtggatagctggagtggtgaggtctgtgaaagaaggtgaaaggg/g 10 /SLCO2A1/"solute carrier organic anion transporter family, member 2A1"/ 2818/2/rs206811/31490419/[c/t]/ggtgacatatactgacaccttgtggcaaaccacaatttttttttcataa agggcatctcc[c/t]gcattccccccactccccacccacacacagtgagttctacatgtaagctgcaaatctgtt/c/X DH/xanthine dehydrogenase/ 2819/4/rs890193/185580629/[g/a]/gctgatggacactcgggttgtttccatcttttggcttttgaaagtagt gctgctatgaac[a/g]tttatgttttggtttgaatgttggcttagaattctttgggtatatatccaggtgtaaaat/g/ IRF2/interferon regulatory factor 2/ 2820/6/rs9322464/154790322/[t/c]/ttttagtttcatatcaatgtctttcaaaagcaagccacattgtaggc tgcaagaagaaag[c/t]attcaaccagctctacttctcacaaattcaaaatgtttgaggggctaaagacaactctac/t /CNKSR3/CNKSR family member 3/ 20 2821/15/rs1037958/55310834/[c/t]/gaaaattataaagctaaattttaatttagccaaaaaaaatgcctaaa taaggcctgaata[c/t]aggtattctctttcctaatactttaaaatactggctgatatacagatgactgcagtagta/c /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 2822/15/rs935326/55354536/[t/c]/gatggaccttattcatttgtaacattggaatttccagtggttccatgc gggcacctagaa[c/t]agaaaatatgagtctgagagaagatctgtcatctaggctttcttactactgactttctgg/t/ TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)" / 2823/20/rs2876427/16303254/[t/c]/ggtgccacatacccataagacaagacataaagtgccatgggccacaa gaagggtccagga[c/t]gagcactgcaggcatccagaaggtagagtaattttgactaccaagagcaaagatctctcc/t 30 /KIF16B/kinesin family member 16B/ 2824/9/rs4744150/94670184/[t/c]/tccttgatttttctagcttctagaggccacctgtattctttggcctta aaacaacacaaa[c/t]ttgtcactattctggaggtcatatgtccaaaataggtcctgctgggctgcactccttctg/c/ ZNF484/zinc finger protein 484/ 2825/9/rs4538949/94721048/[t/c]/gcaaaggagaatgatttctttcaattatcataaagcactaagtcagtg gtttgtggaaca[c/t]gttagtcagtgcaaatcaactgaaaacttggtcgtttatttttatttatatttatgtact/c/ LOC642959/similar to Arachidonate 15-lipoxygenase (Arachidonate omega-6 lipoxyge nase) (15-LOX)/ 2826/9/rs4510923/94722122/[t/c]/ggctgtccagggcctcctgggagtcaagtcttccttctttgccaagat 40 gcactgcagctc[c/t]gggaaatcatctctcggtgaggcaagcgggaaggccagtgggggtggagaagaaatctag/c/ LOC642959/similar to Arachidonate 15-lipoxygenase (Arachidonate omega-6 lipoxyge nase) (15-LOX)/ 2827/16/rs2122488/52916974/[t/c]/cagtattaggccgtcaactgtttgttaatttggtcctaagtagctga gccacagtggaac[c/t]gactgatccagaaggctgcaaatacagaaggaaggatacagagaggagatatctgaaaag/c /LOC728792/hypothetical protein LOC728792/ 2828/3/rs2553955/108533687/[t/c]/cttaagagctctaaagtgaaaaacctggattggaatccagctttctc tagttacattttc[c/t]tttatcaccctgattgctccacagttagatgaatgtggaggggagagtggaagagggttt/c /LOC649024/similar to citrate synthase precursor/ 50 (213) JP 2010-88432 A 2010.4.22 2829/4/rs750317/37799303/[g/a]/ctatttgaaactaaacttcatgatctcaaagtgcaatcttcctatgtga gcttgcactgc[a/g]tctctttttccagccacctttgtctttgtcaaggctgagccttctcaactttcttctgga/a/T BC1D1/TBC1 (tre-2/"USP6, BUB2, cdc16) domain family, member 1" 2830/4/rs4632736/110236655/[c/t]/actgagtgaagggttaggaaactgaagtggagcgaacgtgtctggaa ttggaatgacggg[c/t]tagacagctatagaacaatgggttggcgacatgagagccaaatgaatgttgtcattatca/t /COL25A1/"collagen, type XXV, alpha 1"/ 2831/5/rs1421911/96026703/[c/t]/gtaaaatatatcaattagcacaaatttcacctgctttttgttgtgatg ttgttgttaaag[c/t]ggctccttggaaatctgaaattgcagacgtggctcacattatgtttctattgaatagcac/t/ CAST/calpastatin/ 2832/9/rs1982151/85807085/[a/g]/gccattccttaaataataaaatattaaatagagaggtggtcaactatg 10 tacagaaaagga[a/g]ttcacaaatttctaatgaaaatgattgtaatttacagagttgttctttaagatcatcaga/g/ RMI1/RMI1/ 2833/13/rs7988150/42391632/[g/a]/aaatattcatttaatacaataccaatgctatattttatcattcaacc aaaatacaccttt[a/g]tttatcctccccaaaagctatgcttataatgtactcattctattaacagtgtttaaggct/g /EPSTI1/epithelial stromal interaction 1 (breast)/ 2834/20/rs4911287/31090952/[a/g]/acaggcaagagcctgctgcacctccacagcaccctggagatgttcgc agctcggtggcgg[a/g]gcaaggctccaatgtccctctttctcctagaagtggtgagggaaatcgttcccttcccca/g /BPIL3/bactericidal/permeability-increasing protein-like 3 2835/10/rs5003944/87880306/[g/a]/cagtagagaaggagaggagagaaggagcatctgaatgtcgagaggag ttcggttggagac[a/g]gtcagagagaagatcagctgcaggatggtagaattccaggggaatatagtcttcccactc/g 20 /GRID1/"glutamate receptor, ionotropic, delta 1"/ 2836/1/rs4661627/15658782/[a/g]/ttcctcaccctcttgcacaaaagtattcttgccttgagaaccagtgaa tgttaatccatg[a/g]agagtccctatgctttgtgcttctgtttccctgcggaaataaggcagatctagctgggtg/a/ ELA2A/elastase 2A/ 2837/9/rs12683020/115854482/[a/g]/ggtctcaggaactaccatgccatttcctctcctggagaagttctag gtattacctccaca[a/g]catttccaactgggggactgagcccacttatcagagaagagccgccatccacactggagc/ g/ZNF618/zinc finger protein 618/ 2838/10/rs2358291/19408262/[g/a]/attctacgtatttgtgaatttttctgatttcattctgttattaattt aaatcattctgtt[a/g]tacctggagaacatacttgtatgatttgtatgctcttaaatatattcagatttgttttct/a /LOC100130846/hypothetical protein LOC100130846/ 30 2839/15/rs4965136/95127198/[t/c]/gatggcctacatgggacagcaggacttagtagacaaggccttgcatc cttgcggccctgc[t/c]ttctgtctcatccctcttcccttttgtcttggtcagccgcccaaaggctccagctctgca/c /SPATA8/spermatogenesis associated 8/ 2840/22/rs739172/43540404/[t/g]/agctgcctgcggtttggccggagctgtgggtgtagatgattgagtttc ttttctcacttt[t/g]ccagcaggcaaggggcagctccccgaagggtgtgaacacagggtcccagcctgggtctcg/g/ ARHGAP8/Rho GTPase activating protein 8/ 2841/4/rs2043388/20672923/[g/a]/gtataatggaaggagagatttcttatccatttgtctgtgatttgcttg aggacataggag[g/a]atttaatttacattgtcatctacatccattagcacaggacatatgacaaaattagtgcta/a/ KCNIP4/Kv channel interacting protein 4/ 2842/15/rs2279378/72383547/[c/t]/catctccaccactccgaagctgtgtgaccttggataaatcactccac 40 ctctctgctcctg[c/t]ctcctcattgttaagtagagggaacactgtcaccctgtccacctcttgagactatgggga/c /CCDC33/coiled-coil domain containing 33/ 2843/11/rs507468/102825709/[t/c]/tagaagaaaattagcttataaattgccatattttgtaggtaaacatt tcagtgttttagg[t/c]tgagcaaaatggaattcaatgagtaaaattatggctctaacatgctttcagtaagatcat/t /DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1"/ 2844/15/rs1814585/55296350/[c/t]/ctggtggtaatctacataaaatgcccctatattctacttgtatgcta tggaaaagtcttt[c/t]aagtttgtcgctccaaaacagcatttttcttgaagtctgccttaccccccaaaaaactaa/c /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 2845/2/rs3770244/45486604/[g/a]/gggttagaaggtctaagggaaagtaagataaaaggtggccacagcttc 50 (214) JP 2010-88432 A 2010.4.22 tagcttttcgga[a/g]gtgaggaatagggagaccccagcaataatacatctttggccaaaaatgatgagaagaagt/a/ SRBD1/S1 RNA binding domain 1/ 2846/13/rs9536252/30345375/[t/c]/ttaagggctgcagactaagttcatctttgtgctcccgtgctgcttcc atttcaaaggctt[c/t]gccagcgaatcccgtgagtcattcctggaaccttcaggagtctccatggtgatggggttg/c /hCG_1815504/hCG1815504/ 2847/9/rs10973340/37434994/[a/g]/tccaaggagtgggtctccaaggggggtgggaaaaaaaggaatggata gataacctgatgt[g/a]actgggagtgcttgtaatttaccagtcctatccaagtgtgcagataggtcattaaaaaaa/g /ZBTB5/zinc finger and BTB domain containing 5/ 2848/13/rs723391/45553450/[c/t]/cttttttgaacaaaataattaaaatatgttttaacaaatatttaaaaa tacttctgttta[t/c]ggcattcccctctccccaccaaacttatcacagcagtgacagtttcaccttttatgaagg/t/ 10 CPB2/carboxypeptidase B2 (plasma) 2849/7/rs854524/94736747/[g/a]/ctgatcatgatgtggaagaatctccttgccatcaccaaaccaccaacaa gaaaatattac[a/g]agaaaaaggtattgttaatttctttttctgacttcataacacctcagcttgtacagtata/g/P PP1R9A/"protein phosphatase 1, regulatory (inhibitor) subunit 9A" 2850/15/rs2271552/88639397/[t/c]/tctgagccatgtcctcccgcaggaaagtacatcaccccatatgggag ccaggggacagtg[c/t]caaagatgcggcaccgggaggaggaggagatcgtcaggctggcccaggaccgggaggaga/t /LOC728477/similar to Golgi autoantigen 2851/16/rs8061082/6694529/[c/t]/tcacagcaggctgaacagcaaacccagaggccattgcagctgcctcgg tattctacaccc[c/t]ccttgggtctggaagttgttggaggcaggcataccagactgtttataatatggctgcttt/c/ A2BP1/ataxin 2-binding protein 1 20 2852/2/rs1518013/189336173/[a/g]/actatgctcctgaagactaaggaaactaatgagataaaaggactttc agagtcacaaggc[a/g]tggaggtaaaatgatcttgaagctcactgaaaactgaatgatttggggttggggggcacc/g /DIRC1/disrupted in renal carcinoma 1 2853/5/rs9293690/75926759/[c/a]/ctgttgttagaggcctcagctttgttcacattataaccctttaccttt caggttcagcaa[a/c]tgcattccattcattgcatgatattttctgttaagatcagagctggacattttgcatttc/a/ IQGAP2/IQ motif containing GTPase activating protein 2 2854/6/rs374336/40631948/[t/c]/ggtctgggagagctgggaggagccatggaaatcagaggccctcccacag cccctcctaca[c/t]cttggcccagactgggtagccagctttcctgtctagcagcagggacccagccccgactga/c/L RFN2/leucine rich repeat and fibronectin type III domain containing 2 2855/10/rs10764514/25275787/[a/g]/ctaaagaagtgcctcaaacctatatgccagtgttattatcttagtt 30 aaaactatacattt[g/a]aggcctggcacattggctcatgcctgtaatcccaacactttgggaggctgaagtgggagg/ g/PRTFDC1/phosphoribosyl transferase domain containing 1 2856/16/rs8056742/83650249/[c/t]/ttcctgtgacttgacatggactgttggaccaactattagaccaacta ttgcttagtagtc[t/c]gaaacagccaaaaatctctttttggctcagatagggtgtcatcaaaagacatgtaaacat/t /KIAA0513/KIAA0513 2857/16/rs870149/83654057/[g/a]/tgtctggtgctcgctcacagatctaagatgtcacagcagtgactgtgt gt[a/g]gtcatggcaagggaagcaaccccaccctcttcctctaagaaggaaaggtcattgtgggcc/a/KIAA0513/K IAA0513 2858/19/rs7255657/60594069/[g/a]/tcagtgtgctgagcaaacgtggagacaccatttccctcctctagacc tcatcttggagag[a/g]gagatgttggatggggccatctattccagctttattcacacaaatcatgtctgttggcct/a 40 /RPL28/ribosomal protein L28 2859/22/rs1997719/27958741/[t/c]/cctcccaagccttggaactggctggaatccagttctcggaacactgg gacgcaaaagacc[c/t]ggcggcaggaagtgagtcctgaactcccaaggccacaggcccggcccctcctccaggccc/c /EMID1/EMI domain containing 1 2860/20/rs200184/19999890/[t/c]/ggcagggagtagccaagttggctagccgctggcaaggcctggatcgtg cttcactaatga[c/t]ggcgggggaggaattagtggaagtgtcaaacgtgtgcttccaggtctcacgttgttctcc/c/ C20orf26/chromosome 20 open reading frame 26 2861/13/rs1536002/47324955/[a/g]/tcagcctgaatggggaagtagagcccttctttagggtgaagtggtcc ctataaaggagtt[a/g]gagaatgtgggtaagaagtgcccggaggaaatgaggcagcacatcagaggtggatcttga/g /LOC730174/similar to Nucleosome assembly protein 1-like 1 (NAP-1-related protei 50 (215) JP 2010-88432 A 2010.4.22 n) (hNRP) 2862/3/rs937839/71553486/[t/c]/tttctttggtcaggaggtcctgagaccagcggcccctctgtttctagtg tgaaccattca[c/t]tacgcaggtgtctctgtcctgagtcggctgggttctgatgtttgcatattgtggttatcc/c/F OXP1/forkhead box P1 2863/3/rs7633837/71538465/[t/c]/ctacttttaaggacactggtgattccactgggttcgccgagatactcc aagataacctcc[c/t]cttctcaagggggcaggtgatcaacaaccttaattgcatttgcaaccttaattctccctt/c/ FOXP1/forkhead box P1 2864/7/rs10244332/150431756/[g/t]/agagctccctgatatttagtagctgacccataaccacacttcccca gcgatgcctgaaag[g/t]tcttacagagctttttttgttttcctagataaggatgaaacaggatccaatgtgatacct/ t/CENTG3/"centaurin, gamma 3" 10 2865/8/rs10504041/41584028/[a/g]/cctgaaattaaaaagcaggaggccaaagggatgtttattactgaact gccacagaactag[g/a]agatgtagaatctcaattagcagatccctttcccatgatcacagagcctgcaggcgtctt/g /AGPAT6/"1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid a cyltransferase, zeta)" 2866/19/rs1366234/7118817/[t/g]/ctccctcctcctcctggaataaatatcttaggttcctttttacaatct caccagtcgatg[g/t]catgcaaagtcaatagtgtctgcttttatcaaatgcctaaaatggaagcagacagctttc/g/ INSR/insulin receptor 2867/18/rs1944545/73096412/[g/a]/cttcctttcattctttattcaaatcctacccactgtgctgtgctttc agacaacttattg[a/g]ggattcagcgtcactgatgatttacagaacatttttgcaaggtttgacaattaatgtccc/a /GALR1/galanin receptor 1 20 2868/17/rs1630656/17102612/[a/g]/gtagccattaaaaaacagctgccattaaaaacacaaactctgtttgt gactagtaattga[g/a]gtttagataaaagaacccaaatgctaacaaacataaaagatagtacatgttacaaaagat/g /COPS3/COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) 2869/5/rs1105168/150867075/[g/a]/tgcttagaattgggtccaaatgtgacgagttcatttggaacagaggc cttgctgggttcc[a/g]gttggttgaggttgttgcaggagctggcactcaatgggttgagctcgatggcaggcatgg/a /FAT2/FAT tumor suppressor homolog 2 (Drosophila) 2870/3/rs9876612/171116399/[c/t]/cgtgagccaccacacccagcctgagccctatatttttaaaaataccc ttattgaggaaaa[t/c]ttgatataaaagaactgcacctatttaatgtgtacaatttgatgagttttggcatacgca/t /SAMD7/sterile alpha motif domain containing 7 2871/18/rs9948328/44349982/[t/c]/aatacccagccgcaccagtatacttaacaagtgatttgatttaatac 30 catgtgattaaag[t/c]actacgtttgcagagcctagccattaaaagcaggacagacaacctgtaattaaaattttg/t /KIAA0427/KIAA0427 2872/1/rs2821324/198344629/[g/a]/cctgagaggatcagttcctggaatctgctgtgtatgcaatgacatgc atattgctaggac[a/g]ttaggccacagctccttgggtcagctgttggcagggaacatttgggcagatctgcataag/g /NR5A2/"nuclear receptor subfamily 5, group A, member 2" 2873/2/rs9309208/51344213/[g/a]/cctgtgtgccttgtcacccagcatgctcaatgtataaaataaaattgt gctgtgttcaac[g/a]tagtttattgtaatgataaggacactaatattaagaaatgtcgtgatttattgggcacta/a/ LOC730100/hypothetical protein LOC730100 2874/11/rs949295/120295062/[a/g]/acatttcagacctcacaccgttccctctgccggcaactctctcctcc ttgtcgcctgtca[g/a]attcctacttgtctatcaaggtctgacttgacggcacttccctgagaggcattgcagtgg/g 40 /GRIK4/"glutamate receptor, ionotropic, kainate 4" 2875/4/rs6823734/77055161/[g/a]/tgatcctagtcatgtacttgtctgggctaccggcgctcattaccgtag tataaattgtga[a/g]gctgaaaattatgaggaaattttatgtacacatcattttctctaatatgccagaaaggga/a/ ASAHL/N-acylsphingosine amidohydrolase (acid ceramidase)-like 2876/4/rs2047987/77053569/[g/a]/ctctttgggaaaagcacaggacaggtcctcctgtgactggtgtttctt tttcccgggcac[a/g]tccttagccttggcaaaataactctctcatggactgagtgctgcttcaggcacattttcg/a/ ASAHL/N-acylsphingosine amidohydrolase (acid ceramidase)-like 2877/1/rs10733118/235030633/[t/c]/tttttcacagcccactgagctttgtaatatatagaacacaatcttt agagcttcagtcct[c/t]gctgtgctataataccaacataataagagtagctaatatttatcagatgtttactataca/ c/MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 50 (216) JP 2010-88432 A 2010.4.22 2878/20/rs2327889/14720789/[a/g]/tgaaagatgcattatataacttgcctcatatcatgtatcatgcattt ggtatttaactta[g/a]cgaactgtttgttatcatggaatggcggccactgtttctctttttatgcaatccattaga/g /MACROD2/MACRO domain containing 2 2879/15/rs2665082/97577196/[c/a]/aattttaatcctggctgtgtaactgcaatcttaatgaaatactaaaa attctgaatcttc[a/c]gctcacccacctataatcataatgtcagagagttatttttttaacataatacatatctga/a /TTC23/tetratricopeptide repeat domain 23 2880/1/rs819771/99500510/[c/t]/agtatatgaagtatttctgtgtccttttttatcttgtctgcctcaccca ctagtgaactc[c/t]gtaaagtcaagcacattttcattattatgttttctggtaactacaagtgtgcctggcaaa/t/L PPR4/plasticity related gene 1 2881/2/rs188147/200492230/[g/a]/tgaatggataaacaaagtatatatccatacatagaatactactctgta 10 aataaaaggaac[g/a]gactactggctgggcacagtggctcacgcctgcaatcccagctctttgggaggccaaggc/a/ FLJ38973/hypothetical protein FLJ38973 2882/16/rs11645506/11703080/[a/c]/aataaactcaacctcactatcccaaaaggaagcaaattaaaacaaa agactacttttgac[c/a]ctcaaattgccaagaatttaagacaaaggaaacatcaagtattgatgaaagtaaagaaat/ a/TXNDC11/thioredoxin domain containing 11 2883/5/rs10514231/81343168/[c/t]/ctccttagctaagcacgcaaaactcttgcttaaaaaagattattctt ttgagcctggctt[c/t]gttctctcaacgttacatttgtgcatagcttaattgctgatgattggtcagaggttatgc/t /ATG10/ATG10 autophagy related 10 homolog (S. cerevisiae) 2884/8/rs4639533/53355791/[t/c]/tattattaatgaccttatttaagttattttataatgacaaaatttttc gtttatcaggaa[t/c]atataacaattcgggacttgtaagcatccattaccacagtcttaaaacatgtaaagcaaa/c/ 20 ST18/suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) 2885/10/rs2447011/14072205/[c/t]/aagtggggttaggaataagagccaacctcaaagggctgctctgagga tcagaggagaaaa[c/t]agctgcatagattaagcacatagaaagagctcattaaaggtactttctattcttggctgt/t /FRMD4A/FERM domain containing 4A 2886/14/rs17109462/24536305/[a/c]/accatttccccaacaacaacactcacatacgcaggtgctcatgaac tgaagccaagtcaa[c/a]cttcttgtacttccaaaactcaaacctgacaccatcatccaggcctttactctctcatgc/ c/STXBP6/syntaxin binding protein 6 (amisyn) 2887/14/rs2028377/74080314/[t/c]/ctccttggtgaaggaccagtggggccccccagtgattatggacattc tgcccaaagatgg[c/t]ctctgactgcctcctcagagcaagatagaaccaaagtcaccacaaacagtgaggtcgaaa/c /LTBP2/latent transforming growth factor beta binding protein 2 30 2888/18/rs1275321/790089/[g/a]/ttacaagctattaaactgcatcaaaccttagtttctccatcagactcaa gtagaatgctt[g/a]tttgaaattcatcctgagcgttaatgatactagtttagcacaagtctgccacttcaaaga/a/Y ES1/v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 2889/21/rs2833854/32791311/[g/a]/acaggatggtctgctttttaaagtgactgggcttcattagaaagctg ttagctccagatc[a/g]tgaaatcaaacaggaagtgggaaaactctatccactgaagatagtatttggaatgaatgg/a /C21orf63/chromosome 21 open reading frame 63 2890/22/rs1633399/17563787/[g/a]/tagggcctggcagaggctggcaggagccagcgctctgtatcccctct taccttggtaatg[a/g]tgtccttgaactgaccctccttccaggcctcagtggggtggctcatcatggtgagcacag/a /CLTCL1/"clathrin, heavy chain-like 1" 2891/22/rs807547/17575680/[g/a]/ttgccttggctaaaaccagccgtgtttctgagctagaagattttatta 40 atggacccaaca[g/a]tgcccacatccagcaggtaggccatgccccctgggggctgtgcactgccagtcagattta/a/ CLTCL1/"clathrin, heavy chain-like 1" 2892/22/rs712952/17577949/[a/g]/catacagcgcgctgctgacagcgatgctcgcgatgtccagtgcgtcat agttgtccaggc[a/g]gctgatgtactccatgacccgtgtgcggtctgccttgatggcagtcaggatcaacagatt/g/ CLTCL1/"clathrin, heavy chain-like 1" 2893/22/rs807459/17603352/[c/t]/ctaatacggttcatgcagatgcacacgccagactctaggtcgtacaga tgaagatagcca[c/t]actttgtgatcaagtaaataacaccatgtttagctccaatctataagaagacagagagca/t/ CLTCL1/"clathrin, heavy chain-like 1" 2894/21/rs2834385/34428300/[g/a]/gaggtggtgatttgaggttgatcacactattttaagctctgttccag agcctaactcaaa[a/g]taagtaatcaataattaaatcttgaataaatgagtaattcataagttgggtcattgcaac/a 50 (217) JP 2010-88432 A 2010.4.22 /MRPS6/mitochondrial ribosomal protein S6 2895/3/rs6765537/14730576/[g/a]/agctatccctctggaaacgtcgctgtatgtcagatccccacatgctgc agagggagaacc[a/g]tcacctgcctctttaatgacatacctggattctccttgctggccctattcaatactgaag/a/ C3orf20/chromosome 3 open reading frame 20 2896/3/rs2675187/9154971/[g/t]/tttgtgttcattgtgtttatttttatagttacattccattagtggcaca ttttttgtgtg[t/g]ggggggttccatttatggtggtaccataaagcatcccaggtaaaaagtaagatgatttaa/t/S RGAP3/SLIT-ROBO Rho GTPase activating protein 3/ 2897/20/rs6075340/1842335/[g/a]/ctctgtctacctggttctctccttctcccctattctagctcgctctct cactctgcgtct[g/a]tctctcaggcatgtgtttctctgaggtctttatgatcatgatctttcttttttttgtttc/a/ SIRPA/signal-regulatory protein alpha/ 10 2898/19/rs2074894/2029488/[c/t]/gtccagcccggcgttcagcgacgcctgcgccttcttgtgcagctcgaa gcgctgggtgcc[c/t]ggctcaaacttgcgcttggggcggaatgtcttgtccttgttgaagacttgcttcaggaag/t/ MOBKL2A/"MOB1, Mps One Binder kinase activator-like 2A (yeast)"/ 2899/7/rs7793555/80384681/[a/g]/atcagttatctgccattttatccagatgaccaacaggcagttgttaaa tgatgcagttga[a/g]gtaaccatggactagtgccaaattcaaaccaatgacctagtggtgagcaatccagtgagc/g/ SEMA3C/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3C"/ 2900/16/rs2283508/16180009/[t/c]/tcccccttccacttgagtccaatttcctctttgtattggtcagcttt tgctgtgacaatg[t/c]tatgtaacaaacaacccccagatcccagcagcttacaacagcaggtgtttcttccttatg/c /ABCC6/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 6" 20 2901/15/rs17691453/37331238/[c/t]/aaaaagtgtagggctctttgacttttcatttccctttctatctact tactctttgtgcct[t/c]ctccagttagtaccacactagagaagtgttaggtagaggaagaggaagaaagaaaaaagg/ t/C15orf54/chromosome 15 open reading frame 54/ 2902/2/rs10497101/152980912/[t/g]/aggattgcaaaactacttctagagagactggtgagtagagggatag tgttatggacatac[g/t]gctcattttccagaggtactattgaaactttcttcggtaaccataagggaagaggcagaa/ g/FMNL2/formin-like 2/ 2903/7/rs2043221/14432417/[c/t]/catggctttaaatcacttagcttaatttacagatttctaagtccaatc ttatcctttata[c/t]ataaatagcaaattttcagtgcaatgagccagcatctccaatagtagacagagccactgt/c/ DGKB/"diacylglycerol kinase, beta 90kDa"/ 2904/16/rs1382484/7158130/[c/t]/tgctgctcatagaaaagccatcattgataagtgaactttaatgctgac 30 tgattcaacaga[c/t]ggaaaaccattttgcttccttgaatcttttaaatgtagctaatgctgtcaactattctgg/t/ A2BP1/ataxin 2-binding protein 1/ 2905/21/rs2822538/14572809/[t/c]/atgatttatactatataatttgttataacacagagaacacatttggc gtcaaatacattt[c/t]ctcatctctactttgggcattttgttgtatacgatgaaatttggatttagtcattccttc/t /ABCC13/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 13" 2906/4/rs3025748/114364110/[c/t]/tatcttacctggaacctctaaaatctacagctctaaatctttacaat acccttaattcca[t/c]gtgctatttccagttttctgagagtattatatactctatatttactggaaaacacactca/c /ANK2/ankyrin 2/ 2907/5/rs2366281/63537289/[c/t]/tggatcatcagcatataagttttaggtgaagctgtgagagtagatgag attaccatgcag[t/c]gtatgaatggagtgagagttaagtagttcctatcatacaggaacatttataggatagaca/c/ 40 RNF180/ring finger protein 180/ 2908/15/rs12898794/72671500/[t/c]/agtaagagggaaaagcagttattcacagaggaggagccagaggcct tcagagagctgctg[c/t]gtttccccaccagccattaccccagcacctcactggatgtaggcaagagcagggcaccgt/ c/ARID3B/AT rich interactive domain 3B (BRIGHT-like)/ 2909/15/rs10162901/52114309/[t/c]/acatgatctttactccttagaagctgacttcagaacctcctcagtg gttgcagttcagtt[c/t]agtttgtttcactgtatctatcacaaaagattttaaacctgggagactactctgaagtaa/ c/UNC13C/unc-13 homolog C (C. elegans)/ 2910/13/rs2038823/95749434/[a/c]/ttacattgtgtcaccatattttcattgttgctttatttggttactgc aaccaatagattg[a/c]gaattctacgcaagcagcgactctcttgtctttgaatttccctgtgcctggattaagggc/c /HS6ST3/heparan sulfate 6-O-sulfotransferase 3/ 50 (218) JP 2010-88432 A 2010.4.22 2911/11/rs6483642/20056117/[c/t]/cagttgaactctgtacagaatgattttaggctgaccaataatttttt ctgttccctagga[c/t]tcagaactgaatgagttaagaaaaaccattgagctgctaaagaaacagaacgcagctgcc/t /NAV2/neuron navigator 2/ 2912/6/rs3813331/139396851/[c/t]/ttgtcttgttcaggtcgcgtctgtcactattaatttaccatgttcct tttcctaaaaata[t/c]ttgtgtgatgcatgtggcactgaagtgtccccattttccctctacctttgtaaccgcccc/t /C6orf115/chromosome 6 open reading frame 115 2913/5/rs2195448/81576994/[a/g]/tactattttttcagtcacattcaatcagctgattctgcaagcccagca atttgtattcac[g/a]gaaagtagagtagagaatttacaagtaatttgaggcatgttaacggtgcagacaatcaat/g/ ATG10/ATG10 autophagy related 10 homolog (S. cerevisiae) 2914/2/rs7572356/133493374/[g/a]/tcactggggagtttatcagatttttcttaagcgaaaattaatcaata 10 gggtattttgata[a/g]gggataaagagaagcaaagaggagggcactggtcagtggtggggagaattggggcagggg/a /NAP5/Nck-associated protein 5 2915/18/rs647651/11875553/[g/a]/atgctgattggttcccggaagggtgtttggcaaggggcagtgtatgga gctacgtgtaga[a/g]ggagagaaatttgtgtgtggcttttgtaaattttgaccgattgcagcaattaaatagttg/a/ MPPE1/metallophosphoesterase 1 2916/16/rs1023442/19239066/[a/g]/atgttgaggcttctcactgagcggaggacaatcaggtctgttgaaaa caggagggatcgc[g/a]gaaagaaggtggcttgaaggttgaaatttgtgagccttgatgcatggtgccaccctcaac/a /LOC728276/similar to Lithostathine 1 precursor (Pancreatic stone protein 1) (PS P) (Pancreatic thread protein 1) (PTP) (Islet of Langerhans regenerating protein 1) (REG 1) 20 2917/13/rs2476227/101378302/[c/t]/ctcagacaggaatagtcccaggttctggactgttcctgatgtcttt aatcctcctcccaa[c/t]ggtaagacacatatgccctccgtcccgtttccctctttcatccccggtgacactagaact/ c/FGF14/fibroblast growth factor 14 2918/2/rs1349223/142600718/[c/t]/atgtgcaactctccctccctttccttcagcattttcctggttatagg aattctg[c/t]gtagtaaaaagtaccaatcaaacatactgatagatttctctatcttctgtggctgtctgt/t/LRP1B /low density lipoprotein-related protein 1B (deleted in tumors) 2919/1/rs7519428/108083243/[a/g]/actaattttatttgcatttagttttaaccagggtaatgcttatttgc tgatggaaatttc[a/g]atatcatcctttgctcttcctcctgcctgtgacttctccttcctcataagcatgttcaag/g /VAV3/vav 3 guanine nucleotide exchange factor 2920/1/rs2477106/178231760/[c/t]/actccagaaaacaggatgataatctgactttgggtattcacttgaca 30 tttgtcaataaaa[t/c]gtgttatttgctactctataaaatcttaagtaccagagaaaaaagttctcaaataatggc/t /CEP350/centrosomal protein 350kDa 2921/3/rs84141/8663335/[a/g]/cgcatggaagataaacaaaccaacagctagacctttctgatcttgcttcgg catccgtac[a/g]gaagtgctgtctgcaacagtgtgcttgagtgactcggggcaagtaatgtacccatcaaca/g/C3o rf32/chromosome 3 open reading frame 32 2922/7/rs10266871/104599365/[a/g]/ttctgaacatttaaattgtgttggattagtgaagcaggaatctgac cagatactgagttc[a/g]tgagattcttacccttctactgcctctgcacttgcttgtcctggatttgaatctcaaggt/ g/SRPK2/SFRS protein kinase 2 2923/8/rs2163372/125776010/[t/c]/atcaggatagctaggctttattgaatgtgtaccatgggctgggctct gttctgagtggtt[c/t]atgtgtattaagtctttttgttctcaccacagcctatgtggtaggtacttaccatctttt/c 40 /MTSS1/metastasis suppressor 1 2924/9/rs10988134/130635228/[t/c]/tagatcagccatcagcatgagtgtgaagcagagagaagccgtcaat aaggatcttaataa[c/t]ttaaacattttattatggacgaaaaggagaggcttgaggactcaagcctaaaggcaactc/ c/CCBL1/"cysteine conjugate-beta lyase, cytoplasmic" 2925/11/rs7102192/71325817/[g/a]/aaatattttcattggattcatttaaattaatgccaaattgttcctta tcagtgagtcatc[g/a]gcactgctttctgctcccgtagcgccctgtacagatttccgtcagcacttaccatgtcgt/a /RNF121/ring finger protein 121 2926/11/rs10736781/71328016/[t/c]/cagtctttttggtccactaaccctgtgcccagcctcactgtttggc ttaggcacacttac[t/c]gactccacagttggaacaatggaatggcttacatggcttctataaagtgacatctttcag/ c/RNF121/ring finger protein 121 50 (219) JP 2010-88432 A 2010.4.22 2927/11/rs7948821/71330133/[g/a]/ttaagtttgtggtctgtattaattattcattatttccttcttcaaat acttgtgacttca[g/a]tgtcaaacatttttctaggtcccagtaattcagcagtgaacaagacaactgaggtccttg/a /RNF121/ring finger protein 121 2928/19/rs348337/6481656/[t/c]/agataatacaggcacagaggcacgcatagacataaattggcagagagag agaaagatctc[t/c]ttccacccactgcagaggcaatcaacagagacagagaaagacgttaacggggagacacag/c/T NFSF9/"tumor necrosis factor (ligand) superfamily, member 9"/ 2929/1/rs4661526/14973526/[c/t]/tggttctccgcttatctcctccctttccccttctcacacccacactca ccctcacaatgc[c/t]taccttttcttggttcttgaacagattttttttttttttttttttgagacaagatctcgc/t/ RP1-21O18.1/kazrin/ 2930/5/rs3797373/75908204/[c/t]/gaagtcattttcctggcagagtactctgcctagaggtttatgttgact 10 tcttcctggctc[t/c]tttcctctccaaaggaaaatgcttctacaataattcatggtggtgttggctttctagaga/t/ IQGAP2/IQ motif containing GTPase activating protein 2/ 2931/11/rs2508977/131886523/[g/a]/tgtttttttcaaaatagtggccaatctatgtcctttgtattttcat ataattttataatc[a/g]gtttgacaatatttaccaaaaagatgttaagattttgattgggaatgcatttaaattata/ a/OPCML/opioid binding protein/cell adhesion molecule-like 2932/10/rs7896275/114071985/[g/a]/tgcccagagaatcaatagctactcagttcccagtacaagctttgtt tataggaaagtgtc[a/g]gaagttaattgaagaactgtttgcccataaattaggtatacactgtattcttcctggttg/ a/GUCY2G/guanylate cyclase 2G homolog (mouse) pseudogene/ 2933/7/rs2691546/77804508/[a/g]/aatgattgctgggatgtgtagaatacttaataaccagaactcagaagg tttctgggcact[a/g]tgataattctttctgagaaaccttctggaacatcataggatcatcagggattggctcagt/g/ 20 MAGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2"/ 2934/6/rs9371342/154801956/[t/c]/ttactcaagtgtcaccttctcaaggaggcggctctaggcacgtatct caaactgtactcc[c/t]ctcactccttcctgtgcgccttccctccctagcattgctctaccttaatataaccacata/t /CNKSR3/CNKSR family member 3/ 2935/6/rs2764092/7247506/[a/g]/agtcttcaataattatacagtagtctacaaagctgagtttcactgagta cagcacaggct[a/g]tggggccaacagatctaggtctggatcctgtgttctccaatctatttatgaactgggagc/g/S SR1/"signal sequence receptor, alpha (translocon-associated protein alpha)"/ 2936/1/rs1630519/14988795/[c/a]/ttttttttttttggtaatgaggagcttagagtccttgccttcagagta agaatggggact[a/c]agataagaggacagatgacttgaggacaggacagaacacaccataggcaggagggaggtg/a/ RP1-21O18.1/kazrin/ 30 2937/3/rs9680953/35266795/[a/c]/gaaaaaaagaaagtttgaaaagatgactgaaaggttactggcttgaga aattaaatgatt[c/a]aaatatccaattactgataaaggggaaactgtgaagcactacattcagggggttaaacaa/c/ KRT8P18/keratin 8 pseudogene 18/ 2938/6/rs9395495/13274327/[a/g]/tccctttccctggtgccacttcagccctgcttcctggccctcgaggtt tgcgttggctgc[g/a]ccttcttccagaagcctcttcccccagatatccagatggctggctcctctttccagcctt/g/ PHACTR1/phosphatase and actin regulator 1/ 2939/3/rs2239625/187485434/[a/c]/taggttgtgttctagtgacgctgaaatgtgttcatgctccccaggga attacactcatga[c/a]ctggacttcatcagccacataggtattgcttagacaggtccagaagccaggtggttctcc/a /DGKG/"diacylglycerol kinase, gamma 90kDa"/ 2940/4/rs17054309/169690892/[a/c]/agacatctggaaaaatatacatcaaacctttgggagttgagggaga 40 agactggcttttta[c/a]tttctaccttgctgttgttttaatttttaagatcatcttttattacttttataactaaat/ a/PALLD/palladin/ 2941/8/rs2722413/40542674/[t/c]/tttcaatgagttcaagaatttgggtgacttttctggaatcatagcgct ttagggtttagg[c/t]gttttaaaaattacctgagcattttaaggacaagaaatcaatttatttacttgtcattta/t/ ZMAT4/"zinc finger, matrin type 4"/ 2942/16/rs3115441/20898477/[c/t]/gagatccagtacagctttagttatagacatgaggatatgagaaggca catacactgactg[t/c]gacacgttagaatccaaactctctgaggacatgtcaacagagctgaggcagagaaggatg/t /DNAH3/"dynein, axonemal, heavy chain 3"/ 2943/10/rs1541004/13783523/[a/g]/cgtcctccttgtcactgaagccctggggaagcaagaatcacaaggtt caatcccatttct[a/g]ttgagagaaaccatttctcagtcaacagcttctgtagagaacccactgcgtcctagaagc/g 50 (220) JP 2010-88432 A 2010.4.22 /FRMD4A/FERM domain containing 4A/ 2944/4/rs4689705/7375903/[t/c]/cataatgatagcaaaagaacaaaactgaatgtaagatgaggagcatcct agcagccaaag[c/t]gaaaaggagaactggattggttacagtagtcctgcgacccagagataaagcaagttggtt/c/S ORCS2/sortilin-related VPS10 domain containing receptor 2/ 2945/3/rs10934270/115586437/[t/c]/aagcatgttaaatgcatggaaattaaccagatcggcggcatttgat gtatatatttcaca[c/t]tcttttgcacatattgcacacatacagtgatggcaatgctttctgcaacatatggaaaaa/ c/ZBTB20/zinc finger and BTB domain containing 20/ 2946/3/rs749845/15439322/[t/c]/catattggttaatggcaaagggaattttacaatggaggaattaggtagt tactatcttaa[c/t]cctgtgatcaaaaccagtaagatctccagatattattgcctcatgacaggatgtaatatg/c/M ETTL6/methyltransferase like 6/ 10 2947/4/rs1544392/95994124/[g/a]/tttacttatctcattcttaaatggcttagaaatgttgatcagaaattt ctcagtcattcc[a/g]gtgattttacagcctttttcttcaggatggtgatcagagtacttaacctaccttcctctt/a/ BMPR1B/"bone morphogenetic protein receptor, type IB"/ 2948/4/rs7689088/147457702/[a/g]/actggctgccaattaaaccagaattttataccttttcatcatactgt gctacctctctac[a/g]aatagagtgtgagggaaagtgtactcagttccttcaaagtggcttcataataaagaatat/g /SLC10A7/solute carrier family 10 (sodium/"bile acid cotransporter family), memb er 7" 2949/8/rs1456/22008172/[g/a]/cccaaccaggctactccttcctcacacagcctctttccaaaaggtcagagt gggaccggc[a/g]gctaaatcatcaggagtggagtggcccagggctctgggtcttctgtctgtctggttctct/a/RAI 16/retinoic acid induced 16/ 20 2950/12/rs1894307/11896987/[t/c]/gtgggaaaatgttcaaaacctaatgtggagggaaaagaggatactca actattaaaagcc[c/t]gcttctaactatagaactatagatagtattaacagggcttctgtatcttagtgatgatgg/c /ETV6/ets variant gene 6 (TEL oncogene)/ 2951/19/rs1047854/1432481/[t/c]/gaggctggagcaccccaaaagccaggggaaagtggagggagagaaacg tgacactgtccg[c/t]ctcgggcaccgcgtccaacctcagagtttgcaaataaaggttgcttagaaggtgctcagt/c/ PCSK4/proprotein convertase subtilisin/kexin type 4 2952/22/rs2076154/41795473/[c/t]/aggcccctccttctccctcattctggagacacctgaaatgaaacagg tgccaccacaact[c/t]gcatggacatgctcacgcatcaaagccaacagtcaccacctcagcgcctcgcgccccaaa/t /TTLL1/"tubulin tyrosine ligase-like family, member 1"/ 2953/1/rs10495466/238575190/[a/g]/cactgatagccacataaacagtgatttgcagcagtgcctgacaaca 30 tgttaaatatgaga[g/a]tgtaaatgtcaataacttttcaaatcatgctgagaatttcatcttggtcagtatgtctgg/ a/FMN2/formin 2/ 2954/15/rs1037439/34813857/[c/t]/aatgagctttttttaaaaaaaaaaattataaaagttaaagtaactag ggaaggaataaag[c/t]acctctggaattcttatacccgactacatagtattagtattgttctaaggatgaacaaag/c /C15orf41/chromosome 15 open reading frame 41/ 2955/9/rs1800977/106730271/[t/c]/ggctttgaccgatagtaacctctgcgctcggtgcagccgaatctata aaaggaactagtc[c/t]cggcaaaaaccccgtaattgcgagcgagagtgagtggggccgggacccgcagagccgagc/t /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 2956/4/rs1986369/169694319/[a/g]/gatggttttataaggggctcttcctcgctttgcttgacatttcttcc tgccttgtgctgc[a/g]ttgtgtggaaggtgtcttgctttccctttgccttccgccataattgtaagtttcctgaga/a 40 /PALLD/palladin/ 2957/3/rs11130423/54521096/[c/t]/ggcagtcaagtatgttccagtgggggaaagagattaagagctactgt ccctgggctgact[c/t]agttagttatatatgccacaggtccccctgtttgagaaagggattgccttgctgagggaa/c /CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 2958/1/rs6425233/171660677/[t/c]/cttaaatcctctgagcctcagttgcttcatctgaagaatgcgaccag acaggtggatttt[c/t]aggcatgcaataaggtggcacaccttcaatcagagattctttaaatatttcttattcttt/t /LOC646870/hypothetical protein LOC646870/ 2959/1/rs12092383/171843343/[g/a]/ggtataaaaaaagaacaaaacaaaatccctaccctcaaaaagctta caattcacacagaa[g/a]gacaaacctgtgaacaattaagtagaatacagtatgaggctattagcactatgggtgccc/ g/ANKRD45/ankyrin repeat domain 45/ 50 (221) JP 2010-88432 A 2010.4.22 2960/6/rs389663/117974744/[t/c]/cctgctggacacctccacctgcagatgtcacccgttcctcagcaacca caatcgaatcca[c/t]tgttcctaaccctcaccacagatgctctgtgcattccttgtctaatggcttctcgactgc/c/ DCBLD1/"discoidin, CUB and LCCL domain containing 1"/ 2961/7/rs2159022/102301234/[c/t]/ctccctaacacaggcgttcataacttttcacctggatgactacttga taattggtcacta[t/c]gcatctgtgattcccatatctgtctagcagatagaagtgagcttttcggaatataaatct/t /FBXL13/F-box and leucine-rich repeat protein 13/ 2962/16/rs35184/63593542/[g/a]/ggtgtgtgaccttcaaaagctaggtacatgagaatgaatctgatgtccg gttggataggg[a/g]aaaaataaataaagtggttggtcctgtgaatctttcttttgaaatgtgctgagacagttc/a/C DH11/cadherin 11/ 2963/16/rs12923000/63617912/[t/c]/tactataattctttcaaattttgctttctggagatgctcagaattc 10 agctagctcttctt[c/t]cacatagccaccactcaagaaatatttttggagacaaggatttcttcaatagttaagtga/ c/CDH11/cadherin 11/ 2964/21/rs2836316/38637659/[c/t]/caatgagaacgaaggagcaggtgatagctcttaaacaaccagccagt cccaggttttcag[c/t]ccagtgtttgttcacttatcccagacgcttgactcacgagggaccgtgtttatactggct/t /LOC100131955/"similar to potassium inwardly-rectifying channel, subfamily J, me mber 15"/ 2965/10/rs2399864/12783648/[g/a]/ctgcctgaatttatggcagtctcctaaaaagaatactgggaaatgac atgaaggtcactg[a/g]aagatagatacttaaacattttgatgtagaaagcctggggtgatcatcacagacatgtca/a /CAMK1D/calcium/calmodulin-dependent protein kinase ID 2966/1/rs2995810/112280854/[c/t]/cttggcttcactgtgtgggtgagaggccactgaaagtcctatcctaa 20 ctactcagggaaa[c/t]gtccctgctccctctgtgaagcactctcaggcctccttcctttccaccacagtgcttcta/t /KCND3/"potassium voltage-gated channel, Shal-related subfamily, member 3"/ 2967/4/rs6827840/185581926/[t/c]/ggaaccacaagcaagcatgtggacaaacccaaaactaacctggtctc aacaagtcaatgg[c/t]gagaaggaaaaaaacagaggcccacagtcagcagagacttagagtcataaacaccaaaca/t /IRF2/interferon regulatory factor 2/ 2968/7/rs13221738/70680836/[c/t]/tgccatcttgtctagctctgtccattcaagctgaaggcactgaagac ctggggggtggtt[c/t]gcagactcagggtttcatagtgtctgagccaactgagatcacatcagcagtgggttttga/c /WBSCR17/Williams-Beuren syndrome chromosome region 17/ 2969/7/rs10950267/70681551/[c/t]/gacctcaagggactgttccatctcagcctctcaacatgctgggacca cagccgtgagcca[c/t]tgtgcctggccttatatagaaattatgagccatctggaatagccaaagccccaggaacct/c 30 /WBSCR17/Williams-Beuren syndrome chromosome region 17/ 2970/8/rs7812549/19751449/[g/a]/aagtacatttttatttgtggatactcatatgagtgaccagtcattatg gtcatattagca[a/g]ttagttgcctggtatctaaataggcactaatgtgttttttttcctgctactgatgttttt/g/ INTS10/integrator complex subunit 10/ 2971/8/rs10105359/22688000/[c/a]/ctgtctgctcactgacacacaggtttggcgccagcctgtgccaggct caattttagccag[a/c]gagggaaggaggccccgcagggaggagtcagcaagagaaaaatcaccgatggggggtagg/c /PEBP4/phosphatidylethanolamine-binding protein 4/ 2972/16/rs4888911/77586608/[c/a]/tggctgggaagtagcaaaagtatcttccaagctcagcttctctctgc ttgcattctttcc[a/c]aatacgtgattccaaagcccatgcccaatccttgcactgaagcttttagcaggaaaggtg/a /WWOX/WW domain containing oxidoreductase/ 40 2973/4/rs2290782/89930872/[a/g]/ggttaaacattgttttggggatcacttgggactgagctaatttctttc agcctgcgatcc[a/g]cttcacatgtttggttcatcatctctgatctttcatctaacctgactttctctttgcttc/g/ FAM13A1/"family with sequence similarity 13, member A1"/ 2974/17/rs11078629/1151162/[t/c]/cgcctgtggccccagggtcaggctgaggctgcgcactgggaacctgg cacatcggggctc[c/t]gtggccaactcaaggcgttcctctgggcaagtcacttgtccactccgggactcagtttgt/c /TUSC5/tumor suppressor candidate 5/ 2975/7/rs3779360/8243146/[t/c]/tgcacatcgtaattttgtccccttgaaatgtttttaaatagcctaggaa agctttaatca[c/t]tttaggagtactggttgccaggatcctttctgagaccaaaggagaatgattggattgatt/t/I CA1/"islet cell autoantigen 1, 69kDa"/ 2976/8/rs610125/103154788/[c/t]/tctctatctctatattctcatcatcaaaaacaggacaacttccaaatg 50 (222) JP 2010-88432 A 2010.4.22 tcattttaaaga[t/c]gagatttattgtgagctttcttttatataattatatgtcatgaaatattcttataaaagg/c/ NCALD/neurocalcin delta 2977/12/rs3759193/51114706/[g/a]/aagaagcaagttaattgctttccgtcatgtgctaatgatgcatcttg taaaggactcagc[a/g]aacactgcctcatttctaaaccgctttcttaggcctgggaccaactccgtcctgtccaaa/g /KRT75/keratin 75 2978/6/rs532654/136468472/[a/g]/cagtaatcactctgaagtccagttgtctaatatttaaattgcataaat catagcaatttt[g/a]tctacatcacagagttgttgtaaggaaattataaggtatgtgaaaataatatggtagata/a/ PDE7B/phosphodiesterase 7B 2979/1/rs911713/170569167/[c/a]/gaagctagaagaccaggtgagcatatgcctagacccagttagtaatga gtataattgcat[a/c]gaagccgtacacctgcatattaaaattaagcaatctgaatagatggagcaggcagacaaa/c/ 10 DNM3/dynamin 3 2980/18/rs7242948/38632894/[c/t]/atggagccataaagaaccctcccctcaggatctcagcatgctggaga atcattctggagg[c/t]ttttcacaggtctttaatcataatcaacccaaggaactgcagccagtctcattgcataaa/c /RIT2/Ras-like without CAAX 2 2981/15/rs11636576/48734053/[a/g]/agaaacagaccctaaatgatgcaaatgttggaatcagtagacaaag actctaatgcaggt[a/g]ttataaatatgctgaagggcatacaggaatagacagtcataatgagagtgcacatggtgc/ a/TRPM7/"transient receptor potential cation channel, subfamily M, member 7" 2982/5/rs2438490/148706355/[t/c]/ggggagttgtggccaatctcaattcctactgcttcagaactggagta gggagacagctta[t/c]cagaaggaaccatttttcttctggtcatttccttacatcaccaacaagctgccaaaaaga/t /GRPEL2/GrpE-like 2 20 2983/9/rs7848472/94237292/[c/t]/agggatgaaactcttatcaggcaatctatggtcatctttttcaagatt cagatgtttgtc[t/c]ttatcacccttatttttcattttatttataaatccccaaggttcagagtgattaaaaata/c/ CENPP/centromere protein P 2984/20/rs6087032/9747063/[t/c]/gtccatgctgtgttcagagttaagctccatctctgtccctcactgtga aatctcattgct[c/t]ggtccctctacctatcatgatggccctaaataaagtattttttactctgctttaacgaat/c/ PAK7/p21(CDKN1A)-activated kinase 7 2985/18/rs6508351/20961679/[g/a]/cattaagagaatatatgtacatttcaagtgtggtaatcacttataat aattttgcttttg[a/g]agagcatgcacggactgttttatagtcatgtttgtgagtttaagagtacatgtattaaag/a /ZNF521/zinc finger protein 521 2986/9/rs3935382/93586385/[t/c]/aaatcccacacccaatccatcacgaaatgctgtttgctctatctg[c/ 30 t]agaatgtatcaggacctgccctgctaacatgctgtgggcgactgcagcaccccctggccc/c/ROR2/receptor t yrosine kinase-like orphan receptor 2 2987/2/rs3752689/179020859/[t/c]/tatataattctatgcatacctgcataaaaatccttatttctacatta tatatgtttatta[c/t]ataacatggtaataaagtagaccgtgtcacacctctgaagaaatgcagattagtatttta/c /PRKRA/"protein kinase, interferon-inducible double stranded RNA dependent activ ator" 2988/1/rs2143810/17313441/[t/g]/gcagagcccaggcccctgcctgctctgccaggctgccctcctggtact tatgtttcaggc[t/g]tgcctcctccttgtttgtgatcctccctggagtcaatgaagggctccctgaatgaatgaa/g/ PADI2/"peptidyl arginine deiminase, type II" 2989/12/rs4402334/27622486/[a/g]/tgctttttaaaaatgtaagtgaactcacttctggccatggttcattt 40 cagactctctaaa[g/a]cctgcaatttcctctcagtgtgtgtgaatttttttccaggagtaaagttacttgactcta/a /PPFIBP1/"PTPRF interacting protein, binding protein 1 (liprin beta 1)" 2990/2/rs7568133/144921446/[a/g]/tcttagcttacccataaaatgtattatgatatttctcatatgtctaa catgcctatatat[a/g]ttcttccttccatcactagattttgttgagggcctacaaatatgctctttattatttatt/g /ZEB2/zinc finger E-box binding homeobox 2 2991/5/rs6453417/78146288/[t/c]/tgttgggtgttgttcgttatctttatgtatgtctacctcctgttccct aactcagttata[c/t]ggtcttacaggacaaagaactatggattatatgctttccatgtctacagcaaccttcctc/c/ ARSB/arylsulfatase B 2992/2/rs4673242/203716679/[c/t]/ccagagaaagagagtgctttttcctacagccattgttggtagacagt tctccatgggtct[c/t]ttgtgtttctatatatcttgaatagtgactctggctgcctttgttatgaactagattttt/c 50 (223) JP 2010-88432 A 2010.4.22 /NBEAL1/neurobeachin-like 1/ 2993/18/rs1481280/16909449/[a/c]/ttcagacacactacatctgaggtcctttgggatatcatttcatgaat aactagatggcag[c/a]tgaatataagtttgggtttaacagagagattgggactacaatacagatttgggagtcatg/a /ROCK1/"Rho-associated, coiled-coil containing protein kinase 1"/ 2994/2/rs918282/207700243/[g/a]/gtatttcctaagacagcaatcatttcataatgatttgacaggactgtc ccagcacatccc[a/g]atgggtacttatgcttcttcaattttcaggaggagtaaaaatgccctgtattaggattgc/g/ KLF7/Kruppel-like factor 7 (ubiquitous)/ 2995/11/rs1544506/16949516/[t/c]/catttccttagttaatatttcacagcaccatttttaatagatgcata ataatccactgta[c/t]agaggtgtcatgactaatttagccaacaagtggcaaaagttttttgtttggtttgatttc/t /PLEKHA7/"pleckstrin homology domain containing, family A member 7"/ 10 2996/16/rs3784820/1509253/[a/g]/ccgctttgtacgaccttgttcaaaggacttctggaactcttgttttgg aaaaggttctcc[g/a]ataaggaaaacagccctgccagctgagacagaagctgggccctgaagcgcacaggcgagt/a/ IFT140/intraflagellar transport 140 homolog (Chlamydomonas)/ 2997/17/rs2072253/12796444/[c/t]/atcaataaagtctcatcggaaatcatattaaccaatcattgtaatat ttgataccaacca[c/t]tgtaactgaccatatcagcaagctagtatttaaaaatttggttgttattatttacccctc/c /RICH2/Rho-type GTPase-activating protein RICH2/ 2998/11/rs10750523/132391583/[c/t]/cgtcttcaaagccagcaaaggcctgtcaattcctcctgctacttt gactctctttgatgt[c/t]cctttctgtcatcagctggagaaagtttcttgcttttaagggttcctatgatgacactga /c/OPCML/opioid binding protein/cell adhesion molecule-like 2999/17/rs2240300/44732520/[c/t]/gatagtcccacataatgaggaattgtctgcagaaatgccatagcact 20 cattgagaaacac[c/t]gtggtgtgaaattcatgttgtaggtttgttaagccagtattttctaagttcagtgccaaa/c /ZNF652/zinc finger protein 652/ 3000/11/rs2237892/2796327/[t/c]/caagggtaggtgcctctggcatgagccagatgatgggagctgtcacag gactttgccacc[c/t]ggggtgaggggcctagaaacccctctccaccagatgccttacaccccccatccccacacg/t/ KCNQ1/"potassium voltage-gated channel, KQT-like subfamily, member 1"/ 3001/5/rs949787/90286961/[t/g]/aataatgcatttcccaattttgtattccaaagacctgtatattttattg tctatacttct[g/t]gcctgctgccccaaagcagagagtcctttatatgtttgtttattcaaacatcccaggcct/t/G PR98/G protein-coupled receptor 98/ 3002/2/rs6760105/32160890/[a/g]/tgctgggattacagccatgagccaccgcacctggctctagttctcttc taatcttactat[a/g]gtaatcaaaattttagtgctgatgttataatccaagcccaaatggatattcttatacatt/a/ 30 SPAST/spastin/ 3003/1/rs12117860/115254371/[a/g]/aatcatctgtaactaaacaattaattattgtgttccagggctgtgt ctactgaattgtct[a/g]tcatcatgtttagtctttgaatttacttaatattgactaattttctctttttaaagaatt/ a/SYCP1/synaptonemal complex protein 1/ 3004/7/rs2293496/69890581/[t/c]/agagaaagacttctgtttggacacgctaacagggacttgggacgtgct gatgtataactg[c/t]gactgagacaggaatctgtcgctagctctgctatctcctacggtcaccatatgctacggg/t/ AUTS2/autism susceptibility candidate 2/ 3005/11/rs2200650/7282771/[a/g]/cccctatttggttctactctgcatgtaacttttctggtctgagttcct ccaatatatggt[g/a]gtagtactgtgatcttgctagatttgatctggggactctgccataattctaacaaactga/a/ SYT9/synaptotagmin IX/ 40 3006/7/rs6962350/144155157/[t/g]/aaaagatagcttataaagttaatgagatcttatttaaggcaagagaa acaatttgctcac[g/t]gacaacaaggatgaatcaaaatgttgtcatcaagtataactaatctaattaaaagtacag/g /TPK1/thiamin pyrophosphokinase 1/ 3007/9/rs1929841/106673546/[g/t]/cctggccagtgtgaccaggacatcctttccctctggggctgcactgg ctctttgggggaa[g/t]tgttaccattcagggtcttcaaccctcattctagggacttccagtaacttctcccacctt/t /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 3008/9/rs914978/132267462/[a/g]/ccagactgcaggctgcaccttggcagtcaagtgacgagggttctaaat tgtgctccgtgg[a/g]cccctgggggcctgctgggtgggggaaggaagcaaggcccacggcactctggcccaccca/g/ HMCN2/hemicentin 2/ 3009/15/rs2585082/55045250/[g/t]/ttcccatcatggataactgcaagagtttttttcactcgacttgcaat 50 (224) JP 2010-88432 A 2010.4.22 aagagaataacta[g/t]cctgcaaatggggaatatccctaaagttttatcagacccaaaaaaccctggcactcctct/g /TCF12/"transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) "/ 3010/9/rs13296679/70537808/[t/c]/tgaattttggtgccctcttcctcatagcagaagggaaagttatttga tctaggtgtgggc[c/t]gcaaggtgattgtaaatgctcatgtacttgtgtagttgaattggtggtaacttattttta/t /PIP5K1B/"phosphatidylinositol-4-phosphate 5-kinase, type I, beta"/ 3011/4/rs12507314/26348862/[c/t]/ttaaaaattaagtcatgtagaatcttttttacatataatctataatg gactaaagctttt[c/t]catttcatagctatataaaggaattcaacataaacaactgtggtatcttgaataaaaact/c /TBC1D19/"TBC1 domain family, member 19"/ 3012/2/rs2288709/43857514/[g/a]/catcacaataattgaaaaaaagaaagcattaccccatttttactgcca 10 atgaagaaaaca[a/g]atttttctgcaatttcagctccatcaccttcacttccattaattccccttttttccactt/a/ DYNC2LI1/"dynein, cytoplasmic 2, light intermediate chain 1"/ 3013/17/rs6502671/2852848/[t/c]/ctggggttctggtcctggcactgcctctgctgcgtgaccttgttcctt ccctctctgggc[c/t]tctagttttgtctgtgtgaaatgaggaagttggattagacacctgcaggctgctagccct/c/ GARNL4/GTPase activating Rap/RanGAP domain-like 4 3014/17/rs2070862/1595044/[t/c]/tggcgggcgtggggatgtgagatgggaacagagctttctgtccctgcc acaggaacatgg[c/t]gctgctctgggggctcctggtgctcagctggtcctgcctgcaaggcccctgctccgtggt/c/ SERPINF2/"serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epit helium derived factor), member 2"/ 3015/17/rs1045794/1587459/[t/c]/cccgggacaggcggtggagggcagcgtcctggtcagctcctcctctga 20 ccattccttgac[c/t]gtctggaaggagctggagcagaagcccacccatcactacaagtcagcatccgaccccatc/c/ WDR81/WD repeat domain 81/ 3016/10/rs748103/34499413/[a/g]/gtttgtcacagtggtatataattaactgtttacatgccagtcttcccc agggtagtctct[g/a]tcttgtgcatctctgtgtctaccacctaactcagaggaggcactcaatgaagttattgaa/g/ PARD3/par-3 partitioning defective 3 homolog (C. elegans)/ 3017/6/rs9470263/36449671/[g/a]/tttctcaaccctcgcacacacccttggctgagggcttgtgcacagtgc ataaactgtgca[a/g]ctgtacctcacgttcctgggagcagagacagttctaaggctcatgggattccaagcttta/a/ ETV7/ets variant gene 7 (TEL2 oncogene)/ 3018/4/rs4254724/165888610/[a/g]/caaagaatttgaatggaatcagaaatccaaatggcatatttactcca cagcaatgctgca[g/a]ctttaatcaatagaagatcatgcctttaaagttctgaaagaaaatcatgtccaacagaga/g 30 /LOC653794/similar to Tripartite motif-containing 61/ 3019/1/rs12742115/26952518/[c/t]/acggttatcgtcatggagtccctatgggcttcctctatcaggtcaca tcccaaaataaca[c/t]tgggcagtatttcaactgaagaaatgaaggctttcagggctgtagccagcctggagtgtg/t /ARID1A/AT rich interactive domain 1A (SWI-like)/ 3020/1/rs17580122/224845209/[t/g]/agtccccatcagcttcccagctccctgctccatcgcctgctctcct gtgaagtctttcct[g/t]ctacggccaaacagaattcatcactgttcctggtgtgacccagtgtccttgccagagtgt/ g/C1orf95/chromosome 1 open reading frame 95/ 3021/2/rs6744560/36984162/[c/a]/cctggcatatagaaaggactcaatacctactaacaccaaagttgacca gaacagaccaaa[a/c]gtggcagtgggaagaccatgaaaaaggtaaatgccattaataaaaacgacagacaaacat/a/ STRN/"striatin, calmodulin binding protein"/ 40 3022/2/rs1008839/37105700/[t/c]/aaagtatagacccaataaatgtgctattcaggctctcctctatcatct tcatctcttcat[c/t]ttcctatctcctatgctttaattgtagggaattactactccccaaatataatacaccacc/c/ HEATR5B/HEAT repeat containing 5B/ 3023/4/rs6446501/6455675/[a/c]/tgtctcccggctcactcacaccttcaaagatcagctagtaagaccaggc ggcaggagggc[a/c]gtaatttccactgaggccagaaggggccactttgggctaattagaaccactaagcagtct/c/P PP2R2C/"protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform "/ 3024/5/rs4426911/125806834/[c/t]/ggtataagatttaagtttttaaaaggtctgaagtagacctaagaagt gcatttttacaag[c/t]cccatgcctaaatcgttctgacatagaaagttcttaggccacagtttgagaacctctagt/t /GRAMD3/GRAM domain containing 3 50 (225) JP 2010-88432 A 2010.4.22 3025/6/rs3024389/6194619/[t/c]/tcaatccgttctatgactatttccttaactctccagttagttgctatcc tgcccagcaaa[c/t]acagctgagagaagctgcttaataagaaccaaaatactgagctatttgcatacctgaaga/c/F 13A1/"coagulation factor XIII, A1 polypeptide" 3026/7/rs7808313/18830565/[c/a]/caagatgactaagtgtatatgcaaggaagtaaatttaatgatgggtct gaagtttaaccc[a/c]gataagaaggaaggcaaacatggtggtgggggtgattgatggataagcaaacataaatga/a/ HDAC9/histone deacetylase 9 3027/7/rs4298437/103413113/[t/c]/aaattctagtccattcagaaatttaggtacattgtctcaccaaagct caagtattttggg[c/t]agactcatttacttaacgcttgtctttcatgcacaatgtcttcttctaatggctgacctc/c /RELN/reelin 3028/7/rs11769150/150416686/[t/c]/cttctggagggcgacaagcctcgtgggccggccacaggagggtggg 10 ggcacatctgcttc[c/t]gagcttttcccagagcagggagaggtttccgggctcccctggctccagcttgatgagcag/ c/CENTG3/"centaurin, gamma 3" 3029/8/rs4738202/73103415/[a/g]/ttgttctctaagtgttccaatcgctctgtgtctctgtataatatacag ccatgtcataga[a/g]catagaatttatgaatggttctcagttgatttttgatatttaattctatgaatacctagc/g/ TRPA1/"transient receptor potential cation channel, subfamily A, member 1" 3030/8/rs11778612/73313759/[a/g]/attttcactaatgatagttcttcactaaaaaggtgttagaagaacta agtgttatattac[a/g]ttgataatctgagccaatcattttaaactgccattttctatagatcattaaccttcagtt/g /LOC392232/similar to Transient receptor potential cation channel subfamily A me mber 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensi tive-protein p120) 20 3031/8/rs4738353/74509416/[t/c]/cattttatctctctgagcctctttttcatcatttgtaagctgaaggct acgtgactgcac[c/t]ggattatctgagaggtgaatgccttgaccatagtggtgtttaataaatgagggctttcat/c/ LOC100128126/hypothetical protein LOC100128126 3032/8/rs17327852/132069483/[t/c]/atctcacacaaagtaattctaaccattaaggagacttttcaggaag gatgttattattcc[c/t]atgccattgatgggcaaactaagactcagagcttgctcaagctcactaaaatagtaagta/ c/ADCY8/adenylate cyclase 8 (brain) 3033/9/rs7029673/93581983/[a/g]/atttagaaattaaaacattttggaaaatgttggatttttcagctgagt cctacaggaatt[g/a]tcattggcatggagacatcagctcttaagcaggaatttgtagcatattcttggaagcact/g/ ROR2/receptor tyrosine kinase-like orphan receptor 2 3034/11/rs11033352/4668929/[c/t]/gtaagtctacaccaacagtagagaacatggcagtcagcccaactgca 30 ctgttgattctgg[t/c]gtctgtgcatgagagcttcatcacatcagggtggtagcagtaggagtggtggagtacttg/t /OR51E2/"olfactory receptor, family 51, subfamily E, member 2" 3035/12/rs12580233/6994783/[c/t]/gctctagccccagtcctgtttccttatcaccacttacagcttttgct taatccttcccac[t/c]cacccgctcctaaagttctataaccttcataaaacgttccaactgcttaaattttatgta/t /MBOAT5/membrane bound O-acyltransferase domain containing 5 3036/12/rs2734562/10455596/[g/a]/acaccctagcagctcagtctcttatattctgaggtgtatgatgagat aaactgattcaaa[g/a]tggccctagtgtgaaaacttcctgttcaaatccgaagtgatacattgatgaggaatctgc/a /KLRC3/"killer cell lectin-like receptor subfamily C, member 3" 3037/12/rs1449569/26802734/[g/a]/tcctgtgttctaataagaggccttatatactagacatgcaactttta acagtaacattat[a/g]aagttggaatttttggggaccattatggctagaaagaccatggaatggagaaaggctagc/a 40 /ITPR2/"inositol 1,4,5-triphosphate receptor, type 2" 3038/12/rs7978668/69325443/[c/t]/gagagaatccacaaaactcttggcacagtaactgcccttcagtgagt actaaataaatgc[t/c]gtgtattatttttcttattcttagttaatacgacacctagggtaaccatgtttggaagag/t /PTPRR/"protein tyrosine phosphatase, receptor type, R" 3039/15/rs2289126/29308957/[t/g]/acccaggagacctcagctcacaccctcctgggaaggactgccggcca cttcataggtgga[g/t]cacagaggtgctggctccaccccctgtgtgtgcgtggcactctgtagtcaccagcctggc/g /LOC283710/hypothetical LOC283710 3040/17/rs6502579/17159584/[c/t]/aatgggaagctggctctagggagctgagaattgacatcagacctgaa gagtaagaatgaa[t/c]gggccagtgaagagtcgggacaggccttgcaggccaggagaggagcaggtgccaatgcct/t /NT5M/5' 50 (226) JP 2010-88432 A 2010.4.22 3041/20/rs2424316/20205020/[g/a]/tcttacctggaaaatgagtctacagcagtttatttgtgaaaatgtga aaatgccaattca[a/g]tgtcaaaaatagcatatactacatttcattaatttaatagtgtcattgaccttaaaactg/a /C20orf26/chromosome 20 open reading frame 26 3042/20/rs2207632/25003445/[g/a]/aatcctggataagctaaggaagagggatggaagcaacaaccgaggag taaacatgaggaa[a/g]tgtgttgagaaccaaccctctgggaggcagaacctgtgtggctacagagcctggagccag/a /VSX1/visual system homeobox 1 3043/20/rs6076347/25346790/[a/g]/tgatgtcctaggtatgaccgcttgcttcggatcagagcactcagatg ggaatatggtagc[g/a]tcttgccaaatgcattacgatttcacatggctgctgaagaagtgagttagcattgttcaa/g /GINS1/GINS complex subunit 1 (Psf1 homolog) 3044/20/rs4423675/25350778/[g/a]/taaaaacaggcacatgcaaacacatctgaaaaggtgcagaaaacgaa 10 gatgtacagccca[a/g]tgatgtgtcactgaggaattcccatgtatccatcaccctgttcaagaaagaacattgctc/a /GINS1/GINS complex subunit 1 (Psf1 homolog) 3045/20/rs404775/25429117/[a/g]/cagccaggcaggggctccaggagagtccgggctcactctgagatcatc agtaactgctgt[a/g]acagtggtgcccaacagaaatcgtcatcatcacaacaggcaatttctttccattcatcta/g/ RP4-691N24.1/ninein-like 3046/20/rs2210052/25475984/[a/g]/cccatccacctcttcatctgctgttcatccacattcttggtcacagc ttcataataaacc[a/g]gtaaacatttgtaaatgtttccttgagctttgcaagccacactatcagatgatcaacccc/g /RP4-691N24.1/ninein-like 3047/20/rs2387976/25547560/[t/c]/gtgtatcctgggatcgcctcaagaactgtctgcactggaaatcctgt gttcaggtgagca[c/t]ctgaagaaagtcaaacatgccaggcaatgctggctctttgaaatgcacccagctacagtt/c 20 /NANP/N-acetylneuraminic acid phosphatase 3048/20/rs2664537/39247143/[a/g]/agcggcaggctctgggctgtctgcgaggattctggaagctctcccag gtgcccagcagcc[g/a]ggcatgggaacggcatgtggcagcagagagtcgggtttggctcttccacgtggcaggcgg/g /ZHX3/zinc fingers and homeoboxes 3 3049/20/rs6072317/39314931/[t/g]/ctcttcctcaacacaacaaacgaaccccattaaagtcaaaactgaaa actctggccagga[g/t]tctgttatatgtaagatgcctccttgttgatgttgctatagtcctaattaacagtcgaca/g /ZHX3/zinc fingers and homeoboxes 3 3050/20/rs6072343/39401602/[a/g]/ggtagcttttatcaccacctttgccgatgaaattgaggctcaaagag gtaaattgatttc[g/a]gcatctgtagccccaacctgtgacctctccttccttccttctcgggctcccttcagggat/g /LPIN3/lipin 3 30 3051/20/rs6065338/39421666/[a/c]/tgaagggtgacagcagtgggagtgtggtacagcctctggaaggacac agtgttctccccg[c/a]cccttgtctgggagccaggactgtaccctccgaagccagacatcactgccaacatatccc/c /LPIN3/lipin 3 3052/10/rs9418753/128689989/[g/a]/gcaatagcagcgatatagacattatgagagcagcatattaattcaa tttacttgaattca[a/g]tttacccatagagctaactaacggagtgttccaatgattttaccatttgtgagtgaaaat/ g/DOCK1/dedicator of cytokinesis 1 3053/14/rs2274512/32899031/[t/c]/actcgggatgcgaagctgacgaggatccagtccactgggcgaggcag gcctgtgtgtcag[c/t]ggaggccagtgggccactcagagtgggtagcacagatccctgtccaggctccaagcctga/t /NPAS3/neuronal PAS domain protein 3 3054/7/rs2284211/139323259/[g/a]/gttttccgtgatcatgctgtggtcagatccagcccaaccagagagcc 40 aaaaacaaaacaa[a/g]catacaaaacaaacaaacaaacaaacaaaacccaaatccctggcaagccccacgaaatga/a /TBXAS1/"thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamil y A)" 3055/8/rs3857950/125680051/[c/t]/gtgtttctttaatggcaagtggaacattttcttcattatgagaacat gtgttgcctatta[c/t]ctctgtgcttatgaagatgggggtaggcagtgaacttaatagcttttcagagcttctgca/t /MTSS1/metastasis suppressor 1 3056/2/rs7584995/45571826/[a/g]/ccctccctttttcattcctatttaagagttcaagaatagacacttgcc aaaagtacacta[a/g]atttacgaaaacactttctgtttgatgggaaattttccaataaactattgggaaattatt/a/ SRBD1/S1 RNA binding domain 1/ 3057/14/rs8015440/95961302/[c/a]/ccttgaaaataatcatttaacacattcatttaactaatgtccagtta 50 (227) JP 2010-88432 A 2010.4.22 gatccgattatgg[c/a]ccaggcactgtgatgaggagctgccctcacagccatcgataaagcaaacacagtctatgc/c /AK7/adenylate kinase 7/ 3058/5/rs2114194/94379661/[t/c]/agagactacaaaatatgacctcaagaatttttactacatgtttcattt gtgttgttttaa[t/c]atcattattcctcttgtaattcgatgcctagtaaattattaagagtatattgttgctaaa/t/ MCTP1/"multiple C2 domains, transmembrane 1"/ 3059/8/rs2543046/39938527/[a/c]/aattcttgtttccatccattcatttgctcacctaattcataaacatgg aaatcatcctca[a/c]ttcctcttcttcttagcccaaaaattcaattgtgcaggttatgcactgagaaaaagagcc/c/ INDOL1/"indoleamine-pyrrole 2,3 dioxygenase-like 1"/ 3060/22/rs713711/45249776/[t/c]/tcttgtgctacctgaagttgggtttttttcagtaataataatgtgtaa tgtttatcctga[c/t]tcatctaatgctgagggcctggggatgtggttctttcgtgctctcctccatatcttgtga/c/ 10 CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosop hila)"/ 3061/7/rs3757536/121867133/[t/c]/ctaactttaacagccatttttgttatgtaaagtttgttgccatggga agtataatagtaa[t/c]gttcgtggttccgcatatgaaacaaaattaatcttaaagtttagtaataatcacatttaa/c /CADPS2/Ca2+-dependent activator protein for secretion 2/ 3062/6/rs9392056/463078/[g/a]/aagtaatgtgtggaccttgactgaatcctgatacgaacaaactgtctaaa aagcttctac[g/a]agaatttgaacattgactaaatagctgataaaattaaggaattactgttaactttctcca/a/EX OC2/exocyst complex component 2/ 3063/3/rs6444668/194063955/[c/t]/gttgttttccaagtgggaattgtgatggggcactaacattaattctt gaatcaaaaggaa[c/t]gttagcacatggtgtaagtttagttttttttctttttaactcattcatacacttattaaa/t 20 /C3orf59/chromosome 3 open reading frame 59/ 3064/17/rs11079697/62990552/[t/c]/ctagattagatatgtagattagatagatggatgaatagatagatga ttgatagatattaa[t/c]agataagagagatggatagatagattagctagattaagtagatagatagatgatagatat/ c/PITPNC1/"phosphatidylinositol transfer protein, cytoplasmic 1"/ 3065/3/rs3344/62389174/[c/t]/agctgtattgctgatctaacgtgctgttccagttccttcttttggctctaa gtgggacta[c/t]tctggatacagtcaggggagaagagggtcctggatgtctaacaagcttttcccatcattg/c/CAD PS/Ca2+-dependent secretion activator/ 3066/7/rs978903/94842103/[a/g]/acgtcaaaagttgagttcccagatagaaatcctgctcctcttcctgact cttggatttat[a/g]cctccttctgtttttatcgatccctcctcccttctcactctatactctttccttgcagat/a/P ON3/paraoxonase 3/ 30 3067/11/rs7935013/457339/[c/t]/caccagcaatgggtgagagttcctggaagcgttggtactgtcggttttt aaggttttagc[t/c]gctccgtcgggtatgcagtggcgtctccctgtttccagttcctgaaggacaaatgatgct/c/P TDSS2/phosphatidylserine synthase 2/ 3068/11/rs7930593/492013/[t/c]/ccaagtggtcaggtacgcttgctctcggggtggccttggggtgctggtg gggcaggctgg[c/t]gggtggcggctccctctgaagggtgcattgctctggaacgccttgtttgtggacatgaag/t/R NH1/ribonuclease/angiogenin inhibitor 1 3069/11/rs12293143/695404/[g/a]/ccactgcaccctggccctgttctgagcggtcacagcagctggggagaa gggccatcctgg[a/g]agccgggcagatgaggacggaaccagacagtcccactgtggtgggcagaggtggggcctg/g/ EPS8L2/EPS8-like 2/ 3070/2/rs4465744/15327581/[a/g]/taaggctggattttcttcacctactgcaaccaaaacaacaacagactg 40 aatgcagaaact[a/g]acatgagaatccagctgtgttctattaagccggacatgaaaatgtaacacagtgctgttt/a/ NAG/neuroblastoma-amplified protein/ 3071/2/rs13008370/212350619/[g/t]/ttacagggttcctgcctaaatgaatcatcatccaaggatttacaaa aaattatagccttg[t/g]caccccaaccattatagctatcataaccctactcaacctgtactcttacatacacctcat/ g/ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)/ 3072/9/rs638230/9562790/[g/t]/taagaaaaaaaaggcaaaagttttaggacatttcaacgaatagtgtaacc acatgagaaa[t/g]aagagcaaaaacaaatgtttgatagcattaatattcaatatattccaattataatacccc/g/PT PRD/"protein tyrosine phosphatase, receptor type, D"// 3073/22/rs1894704/25183905/[c/a]/cgcgggcagctgggcaaattcgctatgcatcaggctgacggcctgga ggaagcggcgatc[c/a]tgcggggtggccacctgcggcaggtttgcttccagaagaggacacagagttgtgaagagc/c 50 (228) JP 2010-88432 A 2010.4.22 /HPS4/Hermansky-Pudlak syndrome 4// 3074/22/rs1894706/25184441/[g/a]/gtcgccccaggccccttggctggttcttacccatcagcaagctctga atgcggtcgtaat[g/a]tgtgaagttgtaggtgctgctcgtggaggctgcctcatccctgggcagcgtctctttcag/g /HPS4/Hermansky-Pudlak syndrome 4// 3075/22/rs5752330/25189942/[c/t]/ccacttcctctatggctgcgctgtctcccagcagcggctcctcagcc agcagggacagca[c/t]cagccctttgacgcagtgagtgtagagattcatcctcacgagccccatgcaggactctgc/c /HPS4/Hermansky-Pudlak syndrome 4// 3076/22/rs713998/25192212/[t/c]/ccgccgttctcaagaggcaaccatgcgcctcactacttaccatgttcc tgcggggcatcc[t/c]ctcccgtagggagtctctgaaaacaaacacacacagaagttggcgctgggcaccacattc/t/ HPS4/Hermansky-Pudlak syndrome 4// 10 3077/16/rs3803655/80108983/[c/a]/gtttttggagttcgacgttctctggaggcttgggagatgcagccagg gcgcagagttggc[a/c]gtggctgcagacatctcttttcaatgtggacctcctgccacagccacgagattcaaggat/a /CMIP/c-Maf-inducing protein// 3078/15/rs7178887/51698467/[a/g]/ttttgtctttctgtacctcatgtggggcaatcccttcaaaatttttc ttttagtttgcca[g/a]ttgtcttctcacctgtgtttaatatgttccttaaattgcccattgagttcctaattttga/g /WDR72/WD repeat domain 72// 3079/10/rs10781585/134403359/[c/a]/tgccaggacccaggggcctcagcagaggcgtcttctagggtctga ggaccttgtctccac[c/a]ctgtgtgtccgttggcccgtgtatgtttgatgagcactgacgttcgggggtgccgcctgt /a/INPP5A/"inositol polyphosphate-5-phosphatase, 40kDa"// 3080/10/rs2673418/79010407/[t/c]/gatcccacacacacttctaggaggtaggtgtctctggatccatgtgg 20 cctgtgcatgtga[c/t]gaggggcctcttgctcctgcagaagagccatctgtgctttgcaaaagaggtcagagtccc/c /KCNMA1/"potassium large conductance calcium-activated channel, subfamily M, alp ha member 1"// 3081/3/rs1878269/56454506/[t/c]/aattctacctccaaaattgctcttgaatcttctccgttgtttccactc ctcttgaaccaa[t/c]gtgactcttgcataagctacttcatacctcctaaagcttctcctcttatcgtcctctact/c/ ERC2/ELKS/RAB6-interacting/CAST family member 2 3082/3/rs7646515/56450463/[g/t]/acagccatcactatatgtaacaagaccaccaatcaacccactgaatca ggtgggaagtaa[g/t]aaattattatttaaagccccactccaagttttacagatttttgttacacagcaaaagaac/t/ ERC2/ELKS/RAB6-interacting/CAST family member 2 3083/9/rs11794056/114644464/[g/a]/ttttggtgaggagttactggtgtggtgaggttctgtcagtctatct 30 tcatcatggccttg[a/g]gggaacctaatggtgagtgtttgtcctcatcatttggaagtagtggcctgtgccttagga/ a/SNX30/sorting nexin family member 30// 3084/2/rs2193399/51251682/[t/g]/ataaaatgaaagtactctgggtcacagagaaatttagaagcaaaactc aaatctgaacag[g/t]ataagaagggattattagaggtatgcatttttttattacaacaattgaatggtcttatct/g/ LOC730100/hypothetical protein LOC730100// 3085/15/rs8041405/96131750/[c/t]/tagacccaaattgaatctaaacttgttctacagaagctgatgaacca aaagataatgttg[t/c]agcagatattttgggacagagaagtcaattgacacggagtgtcttcagtgacttaccacg/t /LOC91948/hypothetical protein LOC91948// 3086/7/rs7809952/47341988/[t/c]/tactgttgtacaggacatgaaactagggctcagagaggtccctagaac tgcctgagctca[c/t]ccagataggaagtctcagagccactatatgtgtgcatccagcatttgaccagagagagaa/c/ 40 TNS3/tensin 3// 3087/3/rs4308217/123275877/[a/c]/ccctcccttcttcttgcacttcaaaagcactctcttcctctcttttc acctctaagccac[a/c]ggtatcatctcttccatgggctttcacaaaagtctggatgaacctttgaacttgtatctc/c /CD86/CD86 molecule// 3088/3/rs7651591/6898647/[c/t]/gattagtctaaggcaattgaattgtgtgtgtgtgtgtgtgtgtgtgtgt gtgtgtattag[t/c]atgagctgaaacttgtggaagtccaccttaaaaatatagataaatccaactgtggttcac/t/G RM7/"glutamate receptor, metabotropic 7"/ 3089/1/rs2297829/2973947/[a/c]/gaatctgagcagggaagcggtgccgaccgcggaggatccaaggcagaag gcccagcgcac[a/c]gccgccgccagctcctgcccaacccggctccgctgggcttttcctctggggtggcgccgg/c/F LJ42875/FLJ42875 protein/ 50 (229) JP 2010-88432 A 2010.4.22 3090/1/rs6692151/59765574/[g/a]/tttattttgtcaggctctggggaggattccgaaattatttgctcccta ctagtgcctagc[a/g]ctttatctttgcaaccgcacttaccctgtagagtcatagttgcacaggaaactgtattcc/a/ FLJ10986/hypothetical protein FLJ10986/ 3091/6/rs3134931/32298598/[a/g]/aaggagatgaagggaaacaaatgaaggcagaggagggagtgggcaaga ataggaagaggg[g/a]ccagtgatgtgagttttcctctcctcccctgcccaggtgtgcccctggcttcctgggtga/g/ NOTCH4/Notch homolog 4 (Drosophila)/ 3092/11/rs2030731/63130224/[c/t]/caacgacacccctggagaaccccttcaccttgggaggatgcccacct ctgctttggaggg[c/t]ctagaaacccatacactggctgagctgtgcgcccggcaccaatctaggcacctgggctct/t /HRASLS3/HRAS-like suppressor 3/ 3093/2/rs2300697/31640141/[t/c]/tctttgagatgattagcttgtgaatatctaaaatacagcagaaaacct 10 ttaagttccctg[c/t]ttatgtttttaagtatttatggcatgtcctggtaatactgggagaccttggaactgtcca/t/ SRD5A2/"steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid de lta 4-dehydrogenase alpha 2)"/ 3094/8/rs4557727/1581714/[a/g]/tattgtgggtgtgtctgagagggtgactctggatgaggttagcatttgg aggggtggacg[a/g]ggtgaagcagatgctttccccagtgtgggtgggccacgtcctatctagtggaagaaacaa/g/D LGAP2/"discs, large (Drosophila) homolog-associated protein 2"/ 3095/2/rs2247010/37065606/[g/a]/ttctcttgaaacctagagaaatttcagaaagaaatgggacaagatttg aataacagattc[a/g]ataaagatgatgaacaaggagtcaaatataattctaatatttttagcttataaccttggt/a/ HEATR5B/HEAT repeat containing 5B/ 3096/16/rs9935841/45096893/[a/g]/aagcaaattctcaaattataattcaaattatattctgtaatatgaca 20 ctctgatgtatcc[a/g]gttaagtctgcttaagtccagttctaatatattctaatatccaccaatgatgatggatta/a /FLJ43980/FLJ43980 protein/ 3097/12/rs10160990/37504097/[c/a]/gtaaatgtttcagtcaaattaagtagcacaagactcattttaggag ggttccaggaaaag[c/a]ccaaaagtgtaggatggaattcagatgagaaacgtgtttgcccaaagcttaaatccaaca/ c/CPNE8/copine VIII/ 3098/3/rs7641350/144473916/[c/t]/gtggtctcctgaaggcagtccccttcacctggatacagtgtggcact tcttagatactta[c/t]gaaatagtagttgaattaatgaaggcaacaggctcagagaaggtaaataaattgctcaat/c /SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 3099/15/rs2238324/88807993/[c/t]/tactctttccctttcccaagactgtgagcttcttaaaattgggacag tgcctcttagaat[t/c]gtaaggccagcacctaccataattaggttaaatgatctttctaaaagactgcatttaaga/c 30 /IQGAP1/IQ motif containing GTPase activating protein 1/ 3100/15/rs719473/88799068/[c/t]/gtctgaagtgagaggagtcttgtggaggaccatgcctacaacctgtgc aattcaacctaa[c/t]tccatgtagtgtcaggactacttgttataacagcatttaaaaataacagatcatgttcaa/c/ IQGAP1/IQ motif containing GTPase activating protein 1/ 3101/14/rs2353777/61616009/[t/c]/aatgacttgcccagtgtcatagagctagtaagtggtaggcctgggct tcctaaggaaata[c/t]gaacccagagaaccatgaactttcacccagactatgtgggaaagtttcattgatggatgc/t /SYT16/synaptotagmin XVI/ 3102/4/rs10049581/103411916/[c/t]/aagatagacatatacaatatatgtcttccctgccttcagtgcctct gcaagcaccatcat[t/c]catggacttatagtgcaactgatatatagccaaggtttcctgtgaaaactatctcctaac/ c/SLC39A8/"solute carrier family 39 (zinc transporter), member 8"/ 40 3103/1/rs783622/42139575/[t/c]/atctcatctggacccctctttggaagaactgattgtaaatgcagccccc ttcttagcatc[c/t]ccacttagatgactcaacacacgcataactcggctcagcaccttcccacatgcatgacca/c/H IVEP3/human immunodeficiency virus type I enhancer binding protein 3/ 3104/6/rs1304029/71679974/[g/a]/atttgcatgtagctgtatgttttgaatgatcttcttggggctgatttc tacttttgttgc[g/a]ccatggtccaagagtgtggttagtgtgattcttgtgtttttaatttgctaagaattgact/a/ B3GAT2/"beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)"/ 3105/11/rs609017/128088154/[g/a]/ttttaaacagttcacctcacaaatttatgccattcagtgatggacac aggattgaccttc[a/g]caatgatgtgtacctgaagacttccaaagaaaaagctgctataggtctgctcattagcga/a /FLI1/Friend leukemia virus integration 1/ 3106/17/rs1005631/53088372/[g/a]/atatcaactcaacaatgcatgtactacaactacagctacggctacca 50 (230) JP 2010-88432 A 2010.4.22 gtacatctactac[a/g]gtgcatgcatttagttcagtcccacagatacatacaatctaagaacaggcaggggaggtg/a /MSI2/musashi homolog 2 (Drosophila)/ 3107/1/rs10800120/163871934/[a/g]/cttttaagtgtaatttaaatctggctgtcatgaaggtttggcgctc aaacagattttagc[a/g]tctgtttaatgtagaagtggactggaactagcattctgaaaatgtagtctgaacccaaag/ g/MGST3/microsomal glutathione S-transferase 3/ 3108/5/rs253604/155892667/[t/c]/taacatggtctcctcttcatgaaactggcaagcgtcctgcatggctac cgagaaagccag[c/t]tgggtaagcagcacagatcaacctgtaactactgtttacttctccaagataagatggcat/c/ SGCD/"sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)"/ 3109/6/rs11154490/130036348/[t/c]/aaaagtgttttttctctttataggaaggatagagtaaaggaaatca catttctaagtgtg[c/t]ctgcatgccttaactattagtcaacaatgattcatacatttttaagctcttatctgtctc/ 10 c/ARHGAP18/Rho GTPase activating protein 18/ 3110/16/rs8047401/79304514/[t/c]/ggtcctcagcagccctgcttacttatacaagaatatcccttcagaga ctgcgttccttga[c/t]ggtatggcccatgatctgctgcagtctatggctttttctacctctcctcctgctcataat/c /CDYL2/"chromodomain protein, Y-like 2"/ 3111/1/rs1606357/214587714/[t/c]/atcattgtatgtcacagaactaaccaaaatttctttatcaattgtgg ctttaatatatgt[c/t]gttctaaaactttttgtcatccatagaaaattgttgacctgttttaatcctctttaaaaa/t /USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 3112/2/rs1016387/51352966/[g/a]/aatggatgaaaactgcttagtgtgtttttattaataatagctactaaa tacaatcacatt[a/g]gagatatttgaaaaattgtctatctccatgttctaatgtttgaaaatagatccaacaaaa/a/ LOC730100/hypothetical protein LOC730100/ 20 3113/20/rs6516015/5240086/[t/c]/ggcagagttggtttggggtggaaaaggacccactctgttgtctgtggt gttgtaacaagg[t/c]gattgcttcccaagaaactccagtgctacaaaaaatgaaaccaaaccaaaccagcattat/t/ PROKR2/prokineticin receptor 2/ 3114/16/rs11077003/6095230/[a/g]/ctcaaagcccatgtgggaccaccctccatttttaagttactgttttg gagaatatgtaca[a/g]tgtctactggcacctggtggcaggcaggaatgtttaagctgatcatttgttttaaacgta/a /A2BP1/ataxin 2-binding protein 1/ 3115/8/rs751019/27364502/[c/a]/ttcttagtccttcgctcttgtttcttcctctgcaggaccccatggttta tatgaatgata[a/c]gtccccattggtgagttgccaggagaggccgcctcctccatgccaaggcctgggaaggcc/c/P TK2B/PTK2B protein tyrosine kinase 2 beta/ 3116/22/rs738993/30767340/[a/g]/gtctcatctttgatgctgatctatctctgtcattggtcaggaagctct 30 gtgagggcaaga[g/a]ctctgtgtcttttcatagctgtattccagggtcggtacatatgatctggcacatagaagc/g/ SLC5A1/solute carrier family 5 (sodium/"glucose cotransporter), member 1" 3117/18/rs1880113/28528275/[t/c]/tgttaccagaaaaccctgacatgcgcacaatgcattgtaaactcctc atttactatttaa[c/t]ttatccttctttagatgtgatttgaactggaaggagcatttgtaagcaaacacatagtgt/c /KLHL14/kelch-like 14 (Drosophila)/ 3118/9/rs2184024/100295572/[g/t]/ttcccagaattcagaggaaatcgccaaatagatcaatccagtgagat aaaggataacagt[g/t]gtggatactggagaagggagttttcctaagggaaaaccaggacaaaagaaacagaatcaa/t /GABBR2/"gamma-aminobutyric acid (GABA) B receptor, 2"/ 3119/9/rs3750348/100275144/[g/a]/tgatcatcttgtctgatgacattggccaaaagagcacatttattgtc ctgtgtcactttg[a/g]gcaaatcacttgacctctctgagcctcttgtacctgtaaaatgtggtatgtacaaccctc/a 40 /GABBR2/"gamma-aminobutyric acid (GABA) B receptor, 2"/ 3120/9/rs337589/100536329/[t/c]/cagagcggggctattcccattttgcagacaggacagcagaggctccag acaatgcctttc[c/t]tttctttttcactggactcaagtgtccaaggcttttcatcctaggaagtttgtgtgctgg/c/ ANKS6/ankyrin repeat and sterile alpha motif domain containing 6 3121/9/rs6415847/100573041/[c/t]/ccctgcccagctactcacctgagcggttaagcagctccccaccgtgc cggctcacaccta[c/t]cccactggagccgcccgatgaatgaggcgagtggttgaagtttccagaattggcagaaga/t /ANKS6/ankyrin repeat and sterile alpha motif domain containing 6 3122/13/rs3024718/112861854/[g/a]/acatgctttgggaccctcaggtgggaagaggctccagagaccactg ccgcgggtcaactc[g/a]tttgccttctcctcctggaaatcgcagagcctgctgcaatgtataagtttcttctttatg/ a/PROZ/protein Z 50 (231) JP 2010-88432 A 2010.4.22 3123/20/rs6050690/25513239/[t/c]/cctagaagtcacagcaaaggccgctaagaaacttaccattactcatg acccctcttacta[c/t]tgaccttgaaaatcacttgcccttctccaaggccccgccagcttcatgggtctcttcctg/c /RP4-691N24.1/ninein-like 3124/11/rs2672221/3719744/[g/t]/cacaagtccctaatattaaattgtgtggaatgaatgaaggtattttca gacctctaagta[g/t]tcaaaggttagccttcatattacacttcacttgaagacacattccagaaaattcagaaaa/t/ NUP98/nucleoporin 98kDa 3125/3/rs10510245/3013702/[a/c]/atctttttctcgtgcatatctttttaaagtacatctgtcatcttcctt ctgtcatcctgc[c/a]atagagctattcctttactgaaggaaagaaatggtttatgttaagcttttcagttcatta/c/ CNTN4/contactin 4 3126/1/rs3753617/235691406/[a/c]/gaagggcctggtctgtctcttcctttcaccagcaaccagatgttgct 10 ggtctgtctctaa[a/c]ctctctgtattgcgttcttttaattcttggtccggtctgtcccttcttttcacctctgat/a /RYR2/ryanodine receptor 2 (cardiac) 3127/3/rs4129976/2144803/[a/g]/agacggttaaaaataagccacaaattatctgcaagcagataaagccctg actgtataatc[a/g]ttaccaaccaggctctatcttttcttcccatgtagtaacatgtcactttctttaaaagtt/a/C NTN4/contactin 4 3128/6/rs873460/123766181/[t/c]/ctgccacatttgtcacaggaatggattccactcacttctattttgtta ctgtccacctta[c/t]agctctaaaggtaggcttccttctatgctcttttccattccaaaaccatatccacaatgg/t/ TRDN/triadin 3129/6/rs1933896/123777254/[t/c]/ctaggacaatgtcaactgcttactaatatccaatatattccatggac agcctccctcaag[c/t]aatgaatctcagaatatcatggcaatgtgaaaattcctataactcacatatttctatata/t 20 /TRDN/triadin 3130/11/rs919476/20845201/[a/g]/cagttgatctgtgcctttgcttcttttggggccctgagtatttaatgt cttggagttgtg[a/g]gtttatgtccattgccccaaagttgtggaaagatattagacgttagatgtgagctcctta/a/ NELL1/NEL-like 1 (chicken) 3131/12/rs2359189/49778776/[a/g]/aaaccctctgatctagaaaacagaacactctgccccaggagaactgc tcttgctccatgc[g/a]ctgacaaattaatcatcatctggtaattcaactgtactgaaaaatctacctcatcactga/a /TFCP2/transcription factor CP2 3132/9/rs2057363/27264108/[g/t]/aaataagtgacttttttttaaaaaaagcttttttccaaacctttcctt tggctctgagag[g/t]ctggacatgtagatgcatttttcttctgttctgaagtggcatcaataaaagccttcccat/g/ C9orf14/chromosome 9 open reading frame 14 30 3133/17/rs8064576/55855046/[g/t]/gtcgcctctcattgttggttatgaagacttgagagtatgtgtatgta tacacatggtctg[t/g]gtgtggttgtgtggtgtgtgtgctgtgttggaggagttgatcagccagagtcctgtctct/t /C17orf64/chromosome 17 open reading frame 64 3134/1/rs1395718/37714540/[g/a]/aggtgggtgttgtgaggagggagtgtgcggatcccggagaggagcaag cgttcaggaacc[a/g]tagtagtggtagtaggcagtggtagtagcagttgttgttgttatttcaggggctgggctt/g/ ZC3H12A/zinc finger CCCH-type containing 12A 3135/6/rs9397190/154782462/[c/t]/ggaaaacactacggaggtttcctgaaaaattaaaaagcagcctcact actggatacacgt[t/c]taaaggaaatgagatcagtatgctgaggagatatctgcaccctcatgttcactgcagcat/c /CNKSR3/CNKSR family member 3 3136/9/rs2515614/106724139/[g/t]/agtttgaaatcctgtctttcccatgttgaaaacaaagttggtacaaa 40 accctttagcttt[g/t]gcaaacctcctttaagacccgatttaaatgcttccctcctcatgaagctcttctggatcc/g /ABCA1/"ATP-binding cassette, sub-family A (ABC1), member 1"/ 3137/14/rs3949945/54138572/[g/a]/tgggatccgcctggtaccagagacttctttttttctctcacttgggc tagacccagagac[a/g]ggcttctggtttagaagaggaatgtgggactggctggccatggattagataactgtggaa/g /SAMD4A/sterile alpha motif domain containing 4A/ 3138/6/rs226957/3674345/[t/c]/aattgtggtaaggtgtaagaaaaaataaaggaaaacagtcccccaagcaa ctaaggcatc[c/t]gatggggcagtgagcgatgttcctgttgggtgtggtgtgccaggggagagggagggctgt/t/C6 orf145/chromosome 6 open reading frame 145/ 3139/8/rs11785137/124176563/[a/c]/tcttgtcttcatgtggtattgtttaatatgatcctctgttacctgt atttttcctgtata[c/a]tggttatacctgtattttctaaaaactggaggcttgatctgatttaaggacaagaagaca/ 50 (232) JP 2010-88432 A 2010.4.22 a/WDR67/WD repeat domain 67/ 3140/8/rs952656/124196776/[a/g]/ctatccttaggagaatatgttcttgtatttaggttgatttctagccct tccaaaaatgag[g/a]atttccttacattctctggaattccatgtcctaggctcagtaatgaagctaatccctccc/a/ WDR67/WD repeat domain 67/ 3141/15/rs6495867/34786501/[g/a]/ggggcctagaacagtgaacaaggccacctgtttcgaaatgctgcttc ctaccctggtacc[a/g]tcatttcatctgaactttgccaagttgttacctcgtcctttcttagatctaggatgaagg/g /C15orf41/chromosome 15 open reading frame 41/ 3142/3/rs7628692/144564702/[g/t]/agaggctgctgagactgttcatacaatgccctcaatcaagcaggcct atttgaccagaag[g/t]aagagctttacaaagggagaacagcaaaacagcttcttcaggactatatgattttatcaa/t /SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 10 3143/1/rs12058103/6826186/[g/a]/tagggagttctcagaatagagattggctgttaatggtctcttataatt ttttccttgagg[a/g]tagttttattagtatgagagtaacttaaccatcctcattgtgcagttcttccgcctcagt/a/ CAMTA1/calmodulin binding transcription activator 1/ 3144/2/rs2303537/179074339/[c/t]/gtaagcaaacagcgctcaatcaatgaaagctcatatatccccttaca aacaggtttgtta[c/t]taactaaggagtgctgaggattgctttgtaaatatcgtatctcagatatatatttataga/t /PLEKHA3/"pleckstrin homology domain containing, family A (phosphoinositide bind ing specific) member 3"/ 3145/18/rs500559/32524192/[a/g]/ttattattaaatcgtgagtgcccactacagttcttggcacatgacagg cacttgacaaac[a/g]ttcaataaataaatgaaaagatgaatgaacaaacaaatgatataggcagaggataaacgg/g/ FHOD3/formin homology 2 domain containing 3/ 20 3146/18/rs502154/32524314/[a/g]/aatgtttggatgaaggcagcaaaagtaggaagtcttttcttggggctg tggtttgtggat[a/g]gaaagcccggtgcttcccacagaggaggctctgtcggtctgtggattgagtgtggcttcg/g/ FHOD3/formin homology 2 domain containing 3/ 3147/11/rs5012841/5732306/[c/t]/tatgtctttttataaaataattgatgtttgattggcatctgtgttgaa aacttagactgc[c/t]caataagaattttttactgaatcaataaattaatcaatcaataaaactaaacagacaaac/c/ OR52N4/"olfactory receptor, family 52, subfamily N, member 4"/ 3148/11/rs12363178/5733171/[g/t]/ttgtcctgtggtaatgtcaaggtcaatgccatctatggtctgatggt tgccctcctgatt[t/g]ggggctttgacatactgtgtatcaccaactcctataccatgattctccgggcagtggtca/g /OR52N4/"olfactory receptor, family 52, subfamily N, member 4"/ 3149/22/rs4440/45759124/[g/a]/ggttgtcggttcgctattacttcttgaattacagcttccatatttgccta 30 ccctgaagtc[a/g]tactgctactcttaggttcactactgaacaggacaatttctttgagtagaaaagaaccat/g/TB C1D22A/"TBC1 domain family, member 22A"/ 3150/20/rs6053281/5237644/[g/a]/ggctctccccagcttttgactttctgaagatctaggatgaagctggat cctaccccaacc[g/a]ctggctgcaccctagctaggtatattaatatgcacagtggttgctggggttcttcagcca/g/ PROKR2/prokineticin receptor 2/ 3151/5/rs268999/22662423/[a/g]/tctttgatatttctgttctttttatttagttttcttgctggtatcttct ttgatgccctt[g/a]ggggtttgattctggtataagggatgttaggtcaactagctttgattctggaagatttca/a/C DH12/"cadherin 12, type 2 (N-cadherin 2)"/ 3152/10/rs10822705/67512740/[a/g]/gcacactttttaagtattgtcatatatatattcatccatcagagtc tcatctcccaacac[a/g]gtgcagcatattttcctgaagaaaaagagtcccttccctaaaggaaagtctaaaactatt/ 40 g/CTNNA3/"catenin (cadherin-associated protein), alpha 3" 3153/12/rs719568/18538658/[t/g]/tgggtgggtgtgggtgtgtgtctgtgtgtgtaccaccaaatttaatag gctttgtgaggg[g/t]agatgtagtgtttctttttttagcatataatgtgcatactagttgttgaatacatatttt/g/ PIK3C2G/"phosphoinositide-3-kinase, class 2, gamma polypeptide" 3154/5/rs27650/80411898/[a/g]/aaaaggtaacactgaggcagggcccaaagtacccaaaaggcaaggagaca gggtcccggg[a/g]tacagaagctcacaggtcaacagggtgatgcaaacagtttaggctgaataatgttggagc/g/RA SGRF2/Ras protein-specific guanine nucleotide-releasing factor 2 3155/9/rs10868361/87812427/[t/c]/aaactaaggtttttatgaggttgacaaaatttctgataactccaagt tttttgtctccag[c/t]gtaagtccttaaactttgccgtagtagaggcactgccccgaaaacatgctgccatcagag/c /MAK10/MAK10 homolog 50 (233) JP 2010-88432 A 2010.4.22 3156/9/rs2031999/99373980/[a/g]/acagcccagcacagtcctggcaagcagccagcattcatcaaaatgtca agatgaaccaaa[a/g]aagaggctcactggatggcgggtggtgctgaccagtgctcaggccccaggccagaggaca/a/ TMOD1/tropomodulin 1 3157/5/rs10055872/6363014/[c/a]/aaaaataactttaataaacacatcttacacaattttgggaaaagttca aatgtaattggg[a/c]atcctatatttttatttgttaaatctggcaatgatgccccttaccaagaccatattcttt/c/ FLJ33360/FLJ33360 protein 3158/16/rs1466322/17176986/[c/t]/caggcgtggtcatggagccgggaaggaatgtggacacctgcagaact tacctccctgtcc[c/t]ctctcatggaaaatgggaacagactaggtatctgctccatgacatcaagtgacttcatgg/t /XYLT1/xylosyltransferase I 3159/20/rs1884040/40139908/[c/t]/taccccaacatggcctgagattttttttttttgcaagtttgtttctc 10 cctgaagtcacac[c/t]ttaaattcctaccatttaaaatgataaaagccactgtcttttgtatctgccagctatttc/t /PTPRT/"protein tyrosine phosphatase, receptor type, T" 3160/9/rs610789/9578336/[c/t]/cctctgagcagtttgaatgaccaatctaaatgtgcatactgtcaaaatag aaaatgtaac[c/t]cagtagaagcaaacattgccatgaataaaggaactgaatgaactgaaatcagcaggtcat/c/PT PRD/"protein tyrosine phosphatase, receptor type, D" 3161/13/rs927596/99334817/[t/g]/cccctatcagttactcttcaactcccctgtgccttgcttttggagcaa acgttctagttc[t/g]taagtaatagtcatttctatcactgtctatttaatgtccttcccgccattagactggaag/t/ CLYBL/citrate lyase beta like 3162/16/rs2745106/1481462/[t/c]/gccctgagttcagctgcttctctacacccccattccgccccaagctca tcctcacaatgg[c/t]cacctagtcccctcgtccgtgtcgcccccctaccgtctgctctcctaactgcaccagcat/c/ 20 TELO2/TEL2 3163/15/rs8042361/78459988/[a/g]/agggacaaagaatgaaagggagaaggagctatccaggagaacagggc tagtaggaagaat[g/a]taagaaatctagcaggctggtggccaagcagtggtgtgctagaatctattcatattagta/g /LOC730126/hypothetical protein LOC730126 3164/9/rs11140109/85267948/[c/t]/ttttgttctgaggatttttctatcttgctcaagatgttgttaacatt acatactgaaata[t/c]tcaggattccttgttggtaaaacaatagtttctccctgtctctcaaaataataatgataa/t /FRMD3/FERM domain containing 3 3165/2/rs10167906/66142167/[c/a]/gaatttcagcaagtgtagctgttataaacagctttcttagaagcctg tttgctttcagaa[a/c]tctttgaaaaatgacttctcatggagaactatctctgcagagaatgtctcatctatcaag/a /FLJ16124/FLJ16124 protein 30 3166/4/rs7693542/169731002/[c/t]/ctcaaaagtcaccatctcaggaagccctgctctgaacactcccgcca aaggatccctccc[c/t]taccccatttctttctaccccattgcctttttttttgttaattgtgtagcatttaccact/t /PALLD/palladin 3167/12/rs10771015/23708922/[a/c]/tcacaggcatctaaagttaataagcaatataaacagttatcctagt atatcacgtagctc[a/c]aaaaatgtcttctatattgcttatgtattcattcattaattcattcattcaaaaacgttg/ a/SOX5/SRY (sex determining region Y)-box 5 3168/3/rs2616595/2614257/[t/c]/ctcaggtgctgtcttttatgcatgccttcaggctgatgattctcaattc tgcacctttcc[c/t]ggggaacagctgggttacagacaccagatgcatcatgttgctagagctctatgctgaaga/c/C NTN4/contactin 4 3169/10/rs9418698/128711626/[t/c]/gaaacgattagaggtatttattgtggcgagggctcatctgtagtgt 40 ttcagttttacttg[c/t]caagtgctcaccttggctctgctacagcatagatgtcgtcagggtggggctttggagtcc/ c/DOCK1/dedicator of cytokinesis 1 3170/5/rs11134553/168305256/[c/a]/ggaaccctctccacatgctatacttttaatatgttctaggtctgct ttcagttattccaa[a/c]tatatcaacactgagagagagaaaacaatcccgactgctttagggctaaactcgggtgtt/ c/SLIT3/slit homolog 3 (Drosophila) 3171/5/rs6555837/168308872/[t/c]/cttcccttccagtaagtgtcactgagcatgggccacagagaatcctg cagtcatggggac[c/t]gttcagcgtctttgcagacagtccaggaggaatgagaccatgagaaattcaaagcaactg/t /SLIT3/slit homolog 3 (Drosophila) 3172/17/rs7503807/76205706/[c/a]/tgggtacagttttgtaccctcctcttttcagttatgtttgagcatgt cctgtgccattta[a/c]tattctttgagaacatattttttaaacagctctactgagatacaattcacataccccaga/c 50 (234) JP 2010-88432 A 2010.4.22 /KIAA1303/raptor 3173/2/rs1559908/179044593/[t/c]/tatgtcataaaagtgacttgcaaaaatgacttgctaaggggcagcgg gtagcttgtgtca[c/t]cagtatattgccagtgtcctacacagtgcctaatctactacaggcagtccaatatttgcc/c /FKBP7/FK506 binding protein 7 3174/17/rs17249146/28695329/[g/a]/agggatcatgtttcaaccatctttgtaattctctgtcatgcattcc ccagtgcccaatac[a/g]gggtggatgctcagtaaatattttgaatgacccccaggactggttgctagaggaggccag/ a/ACCN1/"amiloride-sensitive cation channel 1, neuronal" 3175/16/rs4784744/55568686/[g/a]/ccctttctttcttttgagctgagctatgtatttaatgaaaccttttc ttgtgtatccagc[g/a]gttcagtggtttcttggggcatgtgatctccttgagcccagtcccacaggctgtaatcga/g /CETP/cholesteryl ester transfer protein 10 3176/5/rs7729876/35261858/[t/g]/cctaaagtgcttggattacaggcatgagccaccacacctggccaagac agtttacttttt[g/t]gggggaatactaggtcttaaaaatctggggtgcgttgtacatttacagtacatctcaata/t/ PRLR/prolactin receptor 3177/4/rs6532149/90399460/[a/c]/caacaaaaatattttttaaaaaacttgaactcttctccagaagaggtg attaaaacattt[a/c]ggtttgttattctttccttctctaatcaagctggatcttaccatctacttgatttgcctg/a/ GPRIN3/GPRIN family member 3 3178/1/rs2274328/8932031/[c/a]/tcgcctatcaacctacagaggacgaaggtgcggtacaacccctccttga aggggctcaat[a/c]tgacaggctatgagacccaggcaggggagttccccatggtcaacaatggccacacaggta/c/C A6/carbonic anhydrase VI 3179/16/rs16947618/48159269/[c/a]/cccagccctctctgatggccagctcctgacattccacttgacaggg 20 tggacccagctcta[a/c]gtactcattccactcattcctggaggggagagccggcctatactcctccggaagtggacc/ a/ZNF423/zinc finger protein 423 3180/15/rs3784556/72119241/[t/g]/atcacactccaaaagtccaggaggtacatcagggaagatccagcctc tcccctcctctgc[g/t]gtattacaccctggtatgaaaatgtcacctgcattcaagactgccacatctataaacaaa/g /PML/promyelocytic leukemia 3181/1/rs9804056/173173791/[t/g]/aaagtgctaggattacaggcatgagccaccgtgcctgtcacatttca ggttattaatgag[t/g]atatttcccttgagctaaaagcatataacacagatttccatctataaataattttacata/t /RABGAP1L/RAB GTPase activating protein 1-like 3182/1/rs737524/27053416/[c/a]/gcctccatgggctgctttggtctgtgggctccttcattcccttggtgat aatttcccttt[a/c]ttctgtgggatttttggtggggttttccccccttttttatggagttggccaataggattg/a/Z 30 DHHC18/"zinc finger, DHHC-type containing 18" 3183/5/rs209350/161443374/[t/c]/attatactttgtacttctttccatctgcactgttttcaaaaaagagtc tcaaatataagc[t/c]gtttaatgaaggatcaagaaatctgaatctgtaagtcactgtttcccaagttcaacgttt/t/ GABRG2/"gamma-aminobutyric acid (GABA) A receptor, gamma 2" 3184/8/rs3134058/120023289/[g/a]/cggaaattgcacatattttggctcacagatcttaatatttcttcctt tgggcttctgtta[a/g]tcatcagatttgagaattagcatcaggtttgaaagccaattcaacagcagggatggccga/g /TNFRSF11B/"tumor necrosis factor receptor superfamily, member 11b" 3185/11/rs907609/1813846/[t/c]/aggaggtgaagggccccgctgcgcaggaccagcggttctgcgagtttcc ggaaagggtga[c/t]gggggaagggcagaccccatgccctgggtggtggggagctgacagggcaggggcccttgg/t/S YT8/synaptotagmin VIII 40 3186/9/rs4841999/137609556/[t/c]/tggtaggagattacgcatgtatgctgtgaaagacctctttgcctaac ataaggatggtaa[t/c]tttagtgcctttggtgttacaaacctttattacctgtggcagctaattaataggagatgt/t /LOC100130954/similar to hCG2021566 3187/9/rs3811133/137609281/[t/g]/tcagcacatgatccagttaaaaagggacctgctgactgaaactgtta gaagccggaaagg[g/t]ggactccaaagtggctgcagcctggtgaagaagagtggccagtgacctcctttccatcag/t /LOC100130954/similar to hCG2021566 3188/7/rs2158836/107368075/[a/g]/atgcccctggggtcacagtcacaggctagaagggaataagcaatgct agctgatctactt[a/g]atcatgaacctcagtgacaagatgtggcatttagaatactcacttcactgtgaaaatggg/a /LAMB1/"laminin, beta 1" 3189/7/rs3735602/107350822/[t/c]/taacgaaagtaattgccaggcccatgtcaactttattgcctaactag 50 (235) JP 2010-88432 A 2010.4.22 ctgtataaaaggc[c/t]agcccctatgtgtttttttcacacattcttagagcaagactattctgtggactgcttaac/t /LAMB1/"laminin, beta 1" 3190/7/rs10263341/107333035/[t/c]/tcctttgaatgatttatcaaacaaattactttaaactttgtgaatt tataaagattattt[t/c]gtaaaggttgttcatgtcaatggatatggaaagataactggcaaaaatcaagtcactgct/ t/DLD/dihydrolipoamide dehydrogenase 3191/6/rs9356941/24748421/[g/a]/actttcaattttttaaagtaaatatgcatgttaaaaataaaacagtcc cttctctataga[a/g]gcttctactatccaggaacaggataagtgatgttaaaaggcatgcccagtgagcaagaat/g/ KIAA0319/KIAA0319 3192/6/rs2179515/24736182/[a/g]/tgatgaataatgtctaacttttcattagcacaattactcagttcattt tgccctagaata[a/g]gcagtatttggaaggaggctcctacattcaggacatgtcttcagcattcttctggtgaac/a/ 10 KIAA0319/KIAA0319 3193/4/rs362492/114358877/[g/a]/attttccaaagaaaaaggttcatttttttgattctaaaatagttgctg tgttttctcaac[g/a]gtcgtcagaattataatgctattctcactccatgtctggtattaacagttttgaaaataa/g/ ANK2/ankyrin 2 3194/21/rs2236694/42094624/[a/g]/cgtcagtctggggcactgcccgccacgtgagcgggtgctggtcacta agctggctcccca[a/g]gggcgtgatggagttgaccagggtcgtcaggttgatgaaatgggccacagactgtgggtt/g /PRDM15/PR domain containing 15 3195/10/rs10828201/21501866/[t/c]/atatgtgttcacccgaagtcaggcaagctgagggggctgcacgaga gctatgtaagtacc[c/t]ctacacctgaccagcttccactaaaatgctggacctcggactctgcccgggatgactgtc/ c/NEBL/nebulette 20 3196/9/rs7852779/16802767/[c/t]/aaatttatttttaaaaactaacattccagttggattcattcaaaatac gtttagctataa[c/t]ttctgaaaaatgttaagcaacaaaaataaaataaaaataaaactgctaattaacaggaca/t/ BNC2/basonuclin 2 3197/6/rs4499954/130020089/[c/t]/ataaatgttttttgcttcctgaggaaattagcactgttattaattgc tttccatggttct[t/c]gtttctttttaagaaaggctttgctgatcatttgcattaatattatgctaataaaagggg/t /ARHGAP18/Rho GTPase activating protein 18 3198/1/rs12749/149822365/[t/c]/tgttttgaatttttctgattcctatagtaccatactctgatgcctatct acttctcaagg[c/t]tgtaggaagagccctaaagaaaaacaccatgggccgggcgcagtagctcaagcctataat/c/T UFT1/tuftelin 1 3199/9/rs4842008/137622530/[g/a]/gaaagatctctgtgttggacacagactagacgacaggagctacgtgt 30 tcttctgcatggg[a/g]accaccacacccagtgctgaccaccacacgatgtgccagtacctggggacgacacagggg/g /LOC138159/beta-lactoglobulin pseudogene 3200/10/rs4626965/19709317/[a/g]/ggtcctctttgttcttggaagtattccacaccatgagttccgcttat tctctctattctg[a/g]tggaattccaacacctattggccctaagtgatttgtatgaattattcccctcagctgttc/a /C10orf112/chromosome 10 open reading frame 112/ 3201/4/rs4692917/173507972/[a/g]/aggccagtgtaacttttgattatcttggtaaactatttattatagta gaattttgaactg[a/g]tgggtaatagagtgagaaacacttggtagcagaaaattatggtttgtagaacatttcttg/a /GALNT17/polypeptide N-acetylgalactosaminyltransferase 17/ 3202/4/rs768425/173515622/[c/t]/aaaaaaagaattgcttaaattttatttcaaactcaaaatgtgtctcca ctaagttggata[c/t]ggacttaataattttgcagaagtattatatgtaaaagtcgaagctgtcaagtgatagagc/c/ 40 GALNT17/polypeptide N-acetylgalactosaminyltransferase 17/ 3203/5/rs2963279/1570322/[c/a]/cggcccatgacaaaagtgctatggttctcaggatggccaggagccgcga ccgtcccctcc[a/c]agtcctgtgggcctcctgtgggtgctggggcatgcttaccattcccggttactgtttcca/c/L PCAT1/lysophosphatidylcholine acyltransferase 1/ 3204/15/rs2009404/47004015/[t/g]/gtaagcagtttctcacgtcaggaagagcttggggaaagcttgggctt tctcatgttgaaa[g/t]tcttacttggtcttattttctgctacttccttgacaggtctgattctgtaatggcttcct/g /SHC4/SHC (Src homology 2 domain containing) family/ 3205/16/rs12597778/81551631/[t/c]/gagccaaggggagatgtgggaagctggagagaaagtggaaaaggac tatgtctataaata[t/c]gcccgatgcaaagcgtggcatagtcacaggcaaaagctatccacttgatctcaagaacaa/ t/CDH13/cadherin 13/ 50 (236) JP 2010-88432 A 2010.4.22 3206/10/rs3814595/3191679/[a/g]/cccgggcatggttccgacctagtctcgtgaaaccaccggaattacaaa gttttgtatgtg[a/g]tatattttgccgaggtgcatgttcatagtaccattctcacactcaaagggacctgtgacc/a/ PITRM1/pitrilysin metallopeptidase 1/ 3207/10/rs3182535/3190292/[c/t]/cttctagatataatggctacacgagggaggcctactttagtgtcggcc tccaagggattg[c/t]ggagaaagacattgagaccgtcagaagcctcatagacagaacgattgatgaagtagttga/c/ PITRM1/pitrilysin metallopeptidase 1/ 3208/8/rs3857949/125679978/[a/g]/gaagatgggggtaggcagtgaacttaatagcttttcagagcttctgc agcgagggtttgc[a/g]gggaggccactggtgcagtgagcatgtcaggtggcttccctggaacagcactggaaacag/g /MTSS1/metastasis suppressor 1/ 3209/8/rs10100725/67142266/[c/t]/aaattagaaggaaatcttctgtggttgacaattactttggtggtcat 10 caacaaccatgcc[t/c]gctggttttcatgtccttgtgttgtaagtcatgaatctgggatggctctctgacccaatt/t /DNAJC5B/"DnaJ (Hsp40) homolog, subfamily C, member 5 beta"/ 3210/6/rs958738/116577254/[c/t]/ctcttagtactggcagggaaataatttagaaaatcataatcctaaaaa tgcagagccagt[c/t]tggtaaagacacactgtctatttgatttcctgtcatacgtactggaagaataagttagta/c/ NT5DC1/5'-nucleotidase domain containing 1/ 3211/4/rs10032932/144728004/[a/g]/agttctataactgtagtgatggaatacacttgcaatttgctcacct caggcatacagcag[a/g]caggtggcctgcactcagaaaagggtggtagggtcattctttcttttctttttaatgaac/ g/FREM3/FRAS1 related extracellular matrix 3/ 3212/4/rs9991328/89932144/[c/t]/tcattatcccagaggtgatcaaaaaatgtttactctttcgcccaagat aattttctttag[c/t]taaagctgtagctctttgttatggccacagacaaacccagaaaaaccacgtaaaatcatg/t/ 20 FAM13A1/"family with sequence similarity 13, member A1"/ 3213/3/rs4685211/14720387/[a/g]/gggccatcccacaagccctagcaatttactcaacatttctctgagggc ccaggccactgg[g/a]tgtaaaggacttaagcacctgttcacatctaatagcttggtcatatacgtctccgggggt/g/ C3orf20/chromosome 3 open reading frame 20/ 3214/2/rs628042/225595388/[t/c]/ttactgtcacagagttgctatgggtaaggtttgtgacttggagccagt tgtggagcccga[c/t]tgtattgattttggctggcaaaactaaaccttcagggaataggtgaaagggcacctgcgg/t/ DOCK10/dedicator of cytokinesis 10/ 3215/2/rs12621870/203066459/[t/c]/tctttattcttcgatgaaatgttttgatgtacaatggtctgcaaat taattcttctattt[c/t]tcttgtatttttaaaattcctagtctgtttacttaaatgtgatctttccattttttattt/ t/BMPR2/"bone morphogenetic protein receptor, type II (serine"/threonine kinase) 30 3216/2/rs1272585/31954563/[g/a]/aaggtcactgtggtagttgtgtggcaaatggattacacaggagggtca gaggtagcaaca[g/a]tggggctgggggcggtggctcatgcctgtaatcccagcagtttggggggccgaggcgagc/g/ MEMO1/mediator of cell motility 1/ 3217/18/rs1421261/52564273/[a/g]/actgacaaatatatttctattcaaggttaattttagggcctgcaata ccatgtcatataa[a/g]tcatcttacaagattcacactggaaaaaaatgtttaaaccttgaaatcattgtccctgac/g /WDR7/WD repeat domain 7/ 3218/9/rs908198/119676622/[t/c]/atgatgactgccttcctggtttatgtcacagagcagctgcaaaatatt ttaacttctact[c/t]ctctttgaaaagcgtccccaaaatacaggcaacagagccccgaagaacgcaggtggcaat/c/ LOC100129489/similar to hCG28178/ 3219/7/rs4431500/32585262/[c/t]/acttactttgggccatgaagagtagtttgttatcatttgaagaaccat 40 taattttataag[c/t]agctatggattttactagggtcactttctttgttagaccttgacagagggacccctgaga/t/ KIAA0241/KIAA0241/ 3220/2/rs10496915/142599063/[c/a]/aattggtttagtcagggagctcagtcaaaatatgtgggcttgtata gagatagcctaaat[a/c]gaaaggatggagagaaagagagatggagagagtgagactgactctacattttaatatcac/ a/LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)/ 3221/2/rs4464317/69290795/[c/t]/aagttttttggagataaagccaatgagactggctgatggatggcttat ccctctttacac[c/t]tgactgtccctccagctctcttcactcctgcagtgtccatccaaaaacactctgcccagg/t/ ANTXR1/anthrax toxin receptor 1/ 3222/3/rs4858074/23372449/[g/a]/tatatctcttacgtaaatcatctaagactttctgaattttgttagatc ctgccatttctt[a/g]ttttacacaggaggctgccagctatcaactgattgaattgattacttcattaaagctaga/g/ 50 (237) JP 2010-88432 A 2010.4.22 UBE2E2/ubiquitin-conjugating enzyme E2E 2 (UBC4/"5 homolog, yeast)" 3223/1/rs3790791/198395881/[t/c]/tactccatggacacagtgcagttgggattgcttgtagcagcttcctg tttctaggctttg[t/c]tccctgcagaaggcaggctagagcccattgttttctatcccctaggtcttagagggtagc/c /NR5A2/"nuclear receptor subfamily 5, group A, member 2"/ 3224/6/rs986475/31664688/[c/t]/cacataccctcttctggctgttaggggagcttgggtccctgaacactgt cattcacccaa[t/c]aaattactatttgaccccagagtgggtggaagggtgagccatgtgttttttttattttaa/t/N CR3/natural cytotoxicity triggering receptor 3/ 3225/14/rs2274736/88008405/[c/t]/cacgactccctgaaaatgcagaaagaaatcgattccaagatgttctt ccttatgatgatg[c/t]gagagtggagttggtcccaactaaagaaaacaacactggttacatcaacgcatcacatat/t /PTPN21/"protein tyrosine phosphatase, non-receptor type 21"/ 10 3226/14/rs2401751/88016375/[t/c]/cccaaccagaacggatactactgtcactctcagacaagcttggatag agcccagattgac[c/t]tcaacggtcggatccgtaatggcagtgtctacagtgcacacagcaccaactccttaaata/c /PTPN21/"protein tyrosine phosphatase, non-receptor type 21"/ 3227/18/rs7242486/54202587/[g/a]/tttcactctcaagttgaaagcttgttatgctgaatacatagactaga aataaggtacctc[a/g]gttcttacctggccacattaattggcactctcgttctgaatatgaacaatcttagctgat/a /NEDD4L/"neural precursor cell expressed, developmentally down-regulated 4-like" / 3228/22/rs5749430/31136331/[a/g]/gacatcactggcgcagcagaacatctaggaactaaacgcaaaaatga cgtaaagatggga[a/g]gggagtgttttaagggaataaagagaaatttttagtccaacatgtgggtcttgggggaga/a /C22orf28/chromosome 22 open reading frame 28/ 20 3229/20/rs6089291/59901255/[c/t]/tccacaaattggcaatttgggctaggctcagctggaaaacccttcca tccttggctgggc[t/c]cattcatccatctctcatcagctgccagtttggcttggggctggctggtcttagagggaa/t /CDH4/"cadherin 4, type 1, R-cadherin (retinal)"/ 3230/16/rs8056397/16197033/[c/t]/gtctcatctgatttttagcaacggtggggtcaacctgatcaattgcc ctgaattttccca[t/c]gttcttcctctctccctctctttcttcctaatgatgacatttatgtactgcacatgaagc/t /ABCC6/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 6" 3231/11/rs609920/131870306/[a/c]/ttcttccattgtaatcccttctgttccattttacccaaaaaacattt attgagccttcat[a/c]cattaggactctgtctctgacttttaggagctctcaattgaataagagtgacaagggcaa/c /OPCML/opioid binding protein/cell adhesion molecule-like 3232/2/rs4953274/45936499/[t/c]/aaagcttctcactgcagtgggtgatgtattgccataaatgggctgaac 30 aatgttttgccc[c/t]tgtgaggaggggcacaataaggctgttgactgctgcccctaacactgacctaccttctgt/c/ PRKCE/"protein kinase C, epsilon"/ 3233/13/rs1952187/45572910/[t/c]/gactccatccttccccgctaagagtcttgcttctacctctgggctct tgttgttgagaac[c/t]ttccatccctttaggtggccctattggatggcatctaacattaagtgtttcttttcattt/c /CPB2/carboxypeptidase B2 (plasma)/ 3234/12/rs3741761/114503248/[t/g]/ctattattgccctaggagaaaactgtagctaaaaaataaataactg attggatatttaaa[t/g]ccaggtctttccaactcaaatggttgcaaggagaaggaagaggaggtagagaagaggaac/ g/LOC100129020/similar to hCG2036637/ 3235/11/rs1487864/7234977/[g/a]/attctaatgtgcagccaagtagagaacaacctttgagaccattgggca aagaatgcatcc[g/a]cctaacccttctcagctcagctcacatttgtttcttgcaaaattaggaaagatagtatca/a/ 40 SYT9/synaptotagmin IX/ 3236/9/rs600075/10287519/[a/g]/tttggcctgggtttttcttccagcaagtatttcttccagtagggaaagt gaattcccagg[a/g]tgagcctgagtaacagtgatgcttagagtttagagatggcacatctctgtaatgagttgt/g/P TPRD/"protein tyrosine phosphatase, receptor type, D"/ 3237/7/rs2299304/104559093/[c/t]/aaatgcctctccacacagcactctctaaattcaaagtgaccatcatt ggccaccggttct[c/t]ttaaccgttcttttctatacctagctaaggcagggacttggtttttgatatggaagaact/t /SRPK2/SFRS protein kinase 2/ 3238/3/rs13068683/144585450/[t/c]/gaagcctccagtcaagcaaatgtgtaactccttataaggagaacag taacggtaaagtcc[c/t]gcctgtttaaaatacctctgattcttcacaggtaagtgtcttctggacatgaatagcccc/ c/SLC9A9/solute carrier family 9 (sodium/"hydrogen exchanger), member 9" 50 (238) JP 2010-88432 A 2010.4.22 3239/3/rs10511055/77469825/[g/a]/cataaccaagtttgttatagtaaataattaatctgtacgtattggtt gatgtttcatttc[a/g]gcatccttgaaacattccatggaactttcatatttccaataaacaacttcaatcagtaat/a /ROBO2/"roundabout, axon guidance receptor, homolog 2 (Drosophila)"/ 3240/2/rs7603262/224344734/[c/a]/tattaaatgatgctctaaagtaaatacaaaaagtttcaagttacatg cagcaaatgcttc[a/c]aataatagtaaactatataactaccataaagctatatataaaataagaataggccgggca/c /AP1S3/"adaptor-related protein complex 1, sigma 3 subunit"/ 3241/3/rs2619566/2599938/[t/c]/ggatgggatgagaagacaactttgacaatctgtgaaatgctccctgttg aagtaacatat[c/t]tgctgcaatgagttgttatgtcaaccatggccagatcttcaaagctccttagaaaagagt/t/C NTN4/contactin 4/ 3242/22/rs2294311/31123269/[a/g]/caattcatacattatttcacacaccctccaagctatccaaaaggacc 10 tatccaatatttc[g/a]ctgcttcctgcttttgttcatgctgcctttgtcaccagtctttgtgtgtaattgtccaaa/g /C22orf28/chromosome 22 open reading frame 28/ 3243/11/rs2220371/7286339/[a/g]/gtatatgagggactctagaaaaagctgctggggcagaagagctgaaag tcccattctgct[a/g]gagaggtaggaccaagatgcaaatggatttaatgtccttattgacgtct/g/SYT9/synapt otagmin IX/ 3244/3/rs972685/15459273/[t/c]/ttcataccttttaaaaactgaagttcgtccttcagttttgaatgtcaca ccttttaaaag[c/t]tgaggtatacttcctaatgattataaacaccaaattaaaaaggaatccatttagttagct/c/E AF1/ELL associated factor 1/ 3245/3/rs1997366/62414626/[t/c]/gtgctgggccagttgggaggcactatttccatgtgagcactgggtcaa atgctacatgga[c/t]gcatatacatcatgaggccattgtccgttgcttccttttataagagggccagagtttgta/t/ 20 CADPS/Ca2+-dependent secretion activator/ 3246/11/rs2129848/67728122/[g/a]/ccaattcaacagctttcccaagtaccctcaggtggtaatgccctcac tcaggccaccaag[a/g]gaatagcgtctgaagctgagcagtttacctaccaccaaggtagaatgcttcacccactgc/g /SUV420H1/suppressor of variegation 4-20 homolog 1 (Drosophila)/ 3247/1/rs7519473/235501533/[c/a]/cagacctaccttgttattattaaaaattcagggagaaatgaagcctt atcaaaaaggcat[a/c]gtttttcatctctttgaatctccacatgcaaccagaaagagctatgaagagggtaaaact/a /RYR2/ryanodine receptor 2 (cardiac)/ 3248/4/rs13145066/110664667/[c/t]/aactcatcaacaagtgtagctggcatttagttcgttgacccattac aatccattataaat[c/t]actgtggtgttttgaacacaggaagctgatatatatttactgaatcctttgatagagctt/ t/SEC24B/"SEC24 related gene family, member B (S. cerevisiae)"/ 30 3249/4/rs10516558/110669445/[t/c]/gtagtcctagagaaagagagttattaatactaatttgggaaaaatt ataatagcatttac[c/t]gaaggatccaaatttttttaaataacagaagcatttaatcagtcctggtgtggtggccca/ c/SEC24B/"SEC24 related gene family, member B (S. cerevisiae)"/ 3250/6/rs332566/48128811/[t/c]/ttaatactgtttgaatatgagttgacttgccacactgatctgggggagc caggatcctta[c/t]atgaatgaatgagagatctcaggtttgctaaaactagtaaatacatctagaagaagagta/c/C 6orf138/chromosome 6 open reading frame 138/ 3251/9/rs3866499/30443151/[g/a]/atgtgatggtatttggagatggagtctttagcagctgattaggtaatg agggttgagtgc[a/g]cacaaatgttattagtgcccctttacatgcctttaaatgctcccagaaagctcttttgtt/a/ LOC401497/similar to PRO2738/ 3252/13/rs9603418/38233046/[a/g]/tatatataggatataagattttggaaagtaccgtagagaaaaactaa 40 ccagaataaaggg[g/a]tagagagggctggagtttgcactgggcttgctgttttataaaaactgaaaagagaagccc/a /FREM2/FRAS1 related extracellular matrix protein 2/ 3253/4/rs7684402/183835963/[c/t]/aacaaaaaaaggttttacttataaataaaaattttagtaagtcagaa actgaattagata[c/t]tctaagttctctccaatattaacagtagaggtctatggtcagtaaaatggcaatatattt/t /ODZ3/"odz, odd Oz"/ten-m homolog 3 (Drosophila) 3254/20/rs734784/43157041/[g/a]/gctctggaggcagccgtgcgcaacagcaaccaccaagagtttgaggac ttgctgagcagc[a/g]ttgatggggtgtcggaggcatctctggagacatcccgagaaacctctcaggagggacagt/g/ KCNS1/"potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 "/ 3255/2/rs2059691/179010130/[a/g]/cagaggggaggcaatttccaaaagattttagagatggcatgatatgg 50 (239) JP 2010-88432 A 2010.4.22 aattaagtaattt[a/g]ttagatttaccaaataaaaatttacattatagaaactttaaaatactgtttttaaataaa/g /PRKRA/"protein kinase, interferon-inducible double stranded RNA dependent activ ator"/ 3256/19/rs3745453/13803221/[c/t]/gaggacccttggccacccagggtggggttgggggaaaatgtgctaca ttgacttagaggg[c/t]cgatttctggaaagtcctgcctcccagcctccctcctggagcccaagccagtctgggtaa/c /ZSWIM4/"zinc finger, SWIM-type containing 4"/ 3257/9/rs1412398/9589213/[g/a]/cgagcatcggaagagttactaatttatgacattatcatgggactcagat aatagaagggt[g/a]ttactttagcattgtgcctagcatgtaaagcactcatataatgtcaccttttattggatt/g/P TPRD/"protein tyrosine phosphatase, receptor type, D"/ 3258/9/rs649649/9564336/[t/c]/tgagttattgaaagtaaaacttattttatcacctgtcaagatgtatcaaa 10 attgggtctc[t/c]ccatgaagcatgatgttagagctccaggaagttgagagtaaagtatgtaactatggaaat/t/PT PRD/"protein tyrosine phosphatase, receptor type, D"/ 3259/9/rs7035962/4054137/[c/t]/tcaagtaatagaataaggcaacattaaaatatagtttatgctaaaggta tcatattgtct[c/t]aataggaaaatgatagaccgtatttaattatgctgagaaaacctatttactgaggaaaaa/c/G LIS3/GLIS family zinc finger 3/ 3260/2/rs7598652/15352418/[t/c]/aaggagttcctagtgccccagatttacaccccacaaccaaatctatgt tcaccaaaacaa[c/t]gaagaaggcttttcttcatgtatattctcacctggtgctttcagactgaagttttcagcc/t/ NAG/neuroblastoma-amplified protein/ 3261/1/rs6698119/48047574/[g/a]/ccttcccgcttgaggatgaatgctctgaggtcaggcaaatcctctgtc ttcatcttgact[a/g]tgttcccagagtgcagtgcccaatacacacatagcagctgcttgaggaatgcttgtagga/g/ 20 LOC388630/similar to C05G5.5/ 3262/10/rs7100619/28604933/[a/c]/atcattatacctcttggagaacctagcacatagtaggtctgcaataa agatgaatactca[c/a]ccatcctcttgaccaaaaaggccatcacatacttttttttttttttttttgagatggagt/a /MPP7/"membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)"/ 3263/11/rs12365487/5766387/[t/g]/caggctttaaaatcaatctccttgagattaaaccacaatatgaagag agtgttgggaagg[g/t]tgctggtgcacatgagcacatctgtgaaggaaagaagggcaaggaagacatacataggtc/t /OR52N1/"olfactory receptor, family 52, subfamily N, member 1"/ 3264/15/rs220030/22750861/[g/a]/aatcctaatttacactcaccctcaggtcttcctatgtgcggtac[a/g ]aaaaagctggtttggaaaagttaaatgcgccataaccacaatcaatgcaaatacgccaga/a/LOC647795/hypoth etical protein LOC647795 30 3265/8/rs7836020/1600639/[a/g]/taaaagtgtggcatgcaactacatttttacaaagaaatcagtttaaaaa atcatttcatc[a/g]gcctgtagcaaacacattataaagtgagaagatgtggtatgtgactttcctgtgatcatg/g/D LGAP2/"discs, large (Drosophila) homolog-associated protein 2" 3266/8/rs1269693/103142636/[t/c]/gagccataaaagagattatccattcaccctggggggctcctacccgt aagtgggtgtctg[c/t]agttctcagagagaagctgatgctttctccctgctcattctgcagatggtcattctgtag/c /NCALD/neurocalcin delta 3267/11/rs11222109/129841446/[g/a]/ccatttagagcttgaagactcccaaatttgcatcttcagtccagg cctcgctcctgacct[a/g]cagacttgcttctctaagggaatctggacgtgtccattggacacctgattagcatcttat /a/ADAMTS15/"ADAM metallopeptidase with thrombospondin type 1 motif, 15" 3268/18/rs6508353/20975827/[t/c]/acaaaataagccccagttttccaattatagagccatgaccctctcca 40 aaacatcaccata[c/t]gactgtcggtgaccagtgtaactttccaacattccatgcgctaggaagtttttgctcatt/c /ZNF521/zinc finger protein 521 3269/18/rs4423505/20979096/[t/c]/aaaactatctctgtagccctggttgtggacatagttttccatactgt gcttgaagctaac[t/c]ttgacttttgtaaccagactgaggtttcaatatcatgcagggcttttctggccattgtcc/c /ZNF521/zinc finger protein 521 3270/22/rs722997/25179666/[t/c]/cagtggcagcagccacagatcctggagttataagtattgcataaagga actgtggagtgc[t/c]ggcttttttgacatactggcagctatgcaatgtgctctgcatacagtctctgctttgccc/t/ HPS4/Hermansky-Pudlak syndrome 4 3271/15/rs2280345/63461230/[g/a]/tactgctacaaagacacaaacctaacacttccaaattacccagagcc caaatcatatata[g/a]tgctagtgagaaatggccactttcttatcaactgtgagttataggcagataccagattta/g 50 (240) JP 2010-88432 A 2010.4.22 /NOPE/neighbor of Punc E11 3272/12/rs10772983/17032849/[c/t]/agagatgagctttcacacttctgcagcagtcaggcattggcacttc tgaacacaaggtag[c/t]gctctgaagaaggtcgtaagtggaaagcacacagaagctatgagaatgggtacacagaac/ t/LOC728622/similar to S-phase kinase-associated protein 1A isoform b 3273/10/rs7077363/95276944/[g/a]/tcttcactgtgctgtaaaatactcatttttaactactccaagttctt agaaaaaaaacac[a/g]aaaaaggaaagtctcaaaggtatgatagaatatcttagtcatttctgtgtataagctgtt/g /CEP55/centrosomal protein 55kDa 3274/4/rs6813901/83784174/[a/g]/gccactgaactaaccaatcctggaggtgctttatccctggtgtcttac tttgagatgcaa[g/a]gatgtcctattgttgaagccagttgagtcaagatgttctgtagagtagctaaaagcatct/g/ SCD5/stearoyl-CoA desaturase 5 10 3275/4/rs6535363/83781593/[g/a]/attctggcagggaagacaatgaacaatataaataagcaaattgtagag cacattagtggt[a/g]aataccaggaagaaaaaaagcagagaaggagaatatgatatattaagggcaggcactgaa/a/ SCD5/stearoyl-CoA desaturase 5 3276/3/rs9848900/123314187/[a/g]/caggcttaaagactgaaagttagtgatatcatcacatttccccttca aaatgctgaattt[g/a]taagcaaatttaaaagtttagaatctaccttttaattgtctgctttcatttttttgacag/g /CD86/CD86 molecule 3277/1/rs2815319/77547654/[g/a]/aattgatcatgattaacaatatattcaactatctggtcccaactaatt ttccagttttat[a/g]tacctgtctacacgttcgacatgctgtaccacttcctgtttttcacagtgatctgctcct/g/ AK5/adenylate kinase 5 3278/1/rs2602948/77530012/[a/g]/ttggacactgaccatctgccaagcacagttctagatcccagggataca 20 gagctccagacc[g/a]taggtaaggcccctgctctcatgaaacttataatccaataggagaagacaaacaatgaat/a/ AK5/adenylate kinase 5 3279/15/rs4776373/65747577/[a/g]/taagatttggttgagatatatgtgcagggactttataaactattgaa tgctaagaatgtg[a/g]catgtttttattataaccatgaattaatcactttattcagttaataagaatacaccactc/a /MAP2K5/mitogen-activated protein kinase kinase 5 3280/8/rs7018169/134625059/[t/g]/ttgcatttatataaaaataaaataattgaaaaaaattaaaaatggaa acgaatgctctgg[t/g]ttcatgagattgagaaaaaaatcaatatattacttagtgcattgtatgtgccaataattt/t /ST3GAL1/"ST3 beta-galactoside alpha-2,3-sialyltransferase 1" 3281/6/rs2714309/7243286/[a/g]/taaagattctggtacaaaaggagaaaatatgaactgtctttaattcaga ggaaataccac[a/g]tctaattacaactataattataacacataatagaagctttccaaataacttgtggcgaaa/a/S 30 SR1/"signal sequence receptor, alpha (translocon-associated protein alpha)" 3282/1/rs10494266/148512176/[g/a]/acacaaggaggccctagcaacactgagctcagttctccatcaccac ggaagttgaacaag[a/g]tgacaggggctaaagtaagggtgaaggagggattattggaaggtgtcacagtctgaaact/ g/C1orf54/chromosome 1 open reading frame 54 3283/1/rs3790806/198354549/[a/g]/ggacacactgttgaactctgtggggcacattgggattatttgcagag cacacaaagtgac[a/g]tctcaactatcattttgccagttctcttacaggggaactttctacttcaaggaaagtcct/a /NR5A2/"nuclear receptor subfamily 5, group A, member 2" 3284/2/rs3769185/173721745/[c/t]/ctcacacctcagagctatacagtcaaagaagtgaagaactctgccaa atttggcaaacca[c/t]gaaattcagtaagggacattccatagagatcagcaaaataacaaatacccacacatttcc/c /ZAK/sterile alpha motif and leucine zipper containing kinase AZK 40 3285/22/rs362139/21191527/[a/g]/gagcttagaggcagatgatccaaaccaagtcaattccgcagagactga caatccagccaa[a/g]ggtttcactgaaacctcatgagtgaccttgagccagaaacagccagctaagccactcttg/a/ ZNF280B/zinc finger protein 280B 3286/19/rs2285745/41282169/[t/c]/gccagttgcctgactgtccgatatccttcaagctaggggacgatgat gtggcagatggct[t/c]ggccttccacgccaagcgcagctaccagccccacggccgctgggcagagcgggccggcca/c /WDR62/WD repeat domain 62 3287/4/rs2139926/141255371/[a/g]/catggcctatcttgtttcatccataccccaaacccacattccctttc catattatagaaa[g/a]cacatgccagaacttatatctgtgaatactgtggagtgtacctttaaaagttatggccta/g /MAML3/mastermind-like 3 (Drosophila) 3288/20/rs726207/15962926/[t/g]/ataatgctgttgacttcattataaggagcagtttgtgggaaagcatca 50 (241) JP 2010-88432 A 2010.4.22 ttacggtatagt[g/t]taccgtggactcagcttctcttcaagctggtgttgatattgacgctgtgttattcctcat/g/ MACROD2/MACRO domain containing 2 3289/21/rs2839498/42674872/[t/c]/accaacagggagaaggtggcaccagacaaagcacacagcccacgaag gctctaaaattat[t/c]gttggaactacagcccaccaatctacctggcagagtcatcagtgcattcattctgtaggc/c /TMPRSS3/"transmembrane protease, serine 3" 3290/16/rs12920365/6150984/[t/c]/ttatcatatcatgactagaacattcgccccttgttcatttgtgttct atctctccttctt[c/t]ctaccgacaatggaatgcgagctccatgagcacagtggtgtttcccagctttattctgca/t /A2BP1/ataxin 2-binding protein 1 3291/7/rs5015755/99851338/[t/g]/tttcttaccacatcttcattttcttcctgggaaacatctaaaatgctt tgtacacagtag[t/g]cacccaacaactatggattatgtgaataaatgactgaatgaatgaaattattctttcggc/t/ 10 ZCWPW1/"zinc finger, CW type with PWWP domain 1" 3292/1/rs1573129/149764000/[c/t]/aaagtccaagatcccaaggcagccttgttctccagcagtgccctcct ctctcagaccctg[c/t]tcttgtcacatgcctgggttgcatcttgcatgctcctgcggagctgctctgtgtctcgct/c /CGN/cingulin 3293/8/rs11249943/9645273/[c/a]/tgggaatggtgaataattttgttttctaagctagcaaatgttaggtga atacatttcctt[a/c]aagagaactggacagttcctttctctcttcctgtaccttatcatgggcagataaacacac/a/ TNKS/tankyrase 3294/7/rs2348460/47813295/[t/c]/tgacagttgctttgccttgcttgtgcgagtgttctgtctcatcagatt catgtattcttt[c/t]acttcaggagaaaagccaaatcttctgcttgggctcctttagaacctgtttctttcctct/c/ FLJ21075/hypothetical protein FLJ21075 20 3295/6/rs13206817/38281343/[t/c]/tgtatttatgcgaagaaaaataaaaataataaaataaaaacttcacc tccaatgcattca[c/t]aaggaactaccagaaaatgtgttccaccaaaacaaaggaccaacttaagataaagaaagt/c /BTBD9/BTB (POZ) domain containing 9 3296/3/rs9872438/113025975/[c/t]/agatatccacccctttctggccaggtatctacttctttctgactcag cccacaacctcaa[t/c]agcctgactagccaaagagttatctaataacttttcccactgttggttctggagtgaacg/t /PLCXD2/"phosphatidylinositol-specific phospholipase C, X domain containing 2"/ 3297/2/rs6430686/137654263/[a/g]/tcaggataaaggcattactgtgtacagtaggtcagagatggaaagat actatgggtcctg[g/a]aagatactgttgagccactgaatcaacagtgtgagcactggctgttatgtgagacaatat/g /THSD7B/"thrombospondin, type I, domain containing 7B"/ 3298/1/rs4332416/216059367/[a/g]/ttgtggttttattcctgcaggatccttttttttccacttttacttcc 30 ttctttcatttct[a/g]actcaaaggtgcatctttctctctctatctctctcttccctagaagcaatagcttcagat/g /SPATA17/spermatogenesis associated 17/ 3299/5/rs919224/76769135/[t/c]/aagaaatcagtggagccctcaactgcttttattcagctcttagcaggaa ctgacaaaaat[c/t]acaatttagcatgacgttacaacgcaaactaaaagcaccctttaggaaagccacatgtta/c/W DR41/WD repeat domain 41/ 3300/1/rs1341511/64263481/[g/a]/gagctcacattatacgacttctagaggtcattcaacttggagattccc tgagtctaggtt[a/g]tggagaaaagttgtctctggcaccagactaatctgctgcccttcctaggggtggaaatat/a/ ROR1/receptor tyrosine kinase-like orphan receptor 1/ 3301/1/rs804136/15006255/[c/a]/gggcttgagaagtgggcccagcacatctattttgctggtgcagatctgg gcaggcacaac[a/c]tggtttcaggacaaccagcaggagggcacagcttcctgactgtggcagaggacattaggt/a/R 40 P1-21O18.1/kazrin/ 3302/13/rs4772158/98372056/[t/c]/tggtgacattctgtgaggtaccaaagagcacttttcagttattacag agaagaaagccta[c/t]gtcagtgtctgcaccttcacaccagcccagggatggtctccttatgctggtggtcagaag/c /DOCK9/dedicator of cytokinesis 9/ 3303/13/rs4444196/98369972/[g/a]/gagccttctgtgtgaggggaaccctgagaaaaatgcctgaatgatct tcattctgagatt[g/a]cttgggcagcttctgactaattggattgcctttatctcatgtgcactgtgaattgcgtga/a /DOCK9/dedicator of cytokinesis 9/ 3304/11/rs671789/124799824/[t/g]/gcccattggcaattgtccttccacctcctagccatgtagatctcacc atgaggtgagcca[g/t]ttcaccaagggacacagcagatgggaagccgcagcctgtcagtgtcaatagacactgagg/g /PKNOX2/PBX/knotted 1 homeobox 2 50 (242) JP 2010-88432 A 2010.4.22 【０１９１】 〔実施例４〕TNF阻害薬群の副作用発現に関連するSNPの探索 Human Hap 300 Bead ChipならびにHuman CNV 370-Duo Bead Chipに搭載されているSNP がTNF阻害薬群の副作用発現の個人差に関連するか否か、フィッシャーの正確確率検定で 解析した。 有意水準0.1%において234SNP（76遺伝子）がTNF阻害薬群の副作用発現に関連していた 。また、有意水準0.1%∼1%の範囲でも933SNP（538遺伝子）が有意に相関していた（表１ ６）。 【０１９２】 〔表１６〕 10 整理番号/染色体番号/NCBI_SNPリファレンス/染色体位置/SNPの種類/配列/副作用非発症 判定SNP/遺伝子シンボル/遺伝子名 3305/12/rs2362470/5742820/[g/a]/atgatatgtcttcgcataatgctattagtcataattttggttattata ttaaaatggtat[a/g]tactatagaaataagcaaattttcttatcaatcatgccttgcttttctcttcttaatttg/a/ TMEM16B/transmembrane protein 16B 3306/16/rs2562109/75931304/[g/a]/agatgataaaaaggacttttcagagagaggccaacatcagaggcaaa ggcacagatttct[g/a]atatttgttaggacatttattcactatctcttaaaaagacttgtaatttttaactctttg/a /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3307/11/rs4930001/2000443/[a/g]/aacagctgtggcggctggagatggccacgctggacggtgcggagctga gacgggccttcg[a/g]agcagagcgggaggtgcgacctgtgcagctgtcactctgctctgtggtttagggtcacca/a/ 20 -/3308/14/rs2301345/73836105/[c/t]/atcactgatttcttactcctctccctcctttcagagcaatttgtgat ctaccaggttggc[c/t]tgatccccagtcagtactatggggtcctgggaaacaaagacttggaagggtttaagactc/t /ABCD4/"ATP-binding cassette, sub-family D (ALD), member 4" 3309/14/rs2301347/73835646/[t/g]/cagctcattaaaacggctcagcagccagagctgctgctcctcctctg cgggaccgaggct[g/t]tgactcaccctggcaccatgtcacacctcccagcctttgaacagtgctttcttgcagaat/g /ABCD4/"ATP-binding cassette, sub-family D (ALD), member 4" 3310/14/rs4148077/73829230/[a/g]/ctgagttacgttgtcatcgcaatccccattttcagcggggtctatgg agacctgagtccc[a/g]cagagcttagcaccctggtcagcaaggtgagactccctcttggtcaccccacatgctgtc/g /ABCD4/"ATP-binding cassette, sub-family D (ALD), member 4" 30 3311/14/rs3742801/73828759/[a/g]/cgggagacgcttctggacatgtccctgaagtcacaggactgcgagat cctgggcgagagc[a/g]agtggggcttggacacgtgagtagcgggctggcagagcagtagttgaggctgcaggctgt/g /ABCD4/"ATP-binding cassette, sub-family D (ALD), member 4" 3312/12/rs3782641/5716281/[a/g]/ttcaagatatcttgttgttgcctcgctttcccaggtcaaggctgctgc tgtttctttctc[a/g]tgggcaccccttcttccctttgctgcccattaaaagccaaccagtcttcaaaaccctgat/g/ TMEM16B/transmembrane protein 16B 3313/11/rs835807/44830408/[g/a]/gctaacattggcccttcttttgtgccaggccctgattaaagaggcctt ggtgaagaggca[a/g]tggcaatgttacatgtgcaatgttacacgtagtaacaacactatcagtaggaactctgat/a/ -/3314/9/rs7856322/9821142/[t/g]/tggtcacccagtagaagcaaagcttcagggtgtagcactgatgtcgtca 40 ttaagcactat[g/t]aaggttaagaggaatttaatgacagcatggttgagtaggtatgttaaaatgcactggata/g/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3315/3/rs10513320/148955065/[t/c]/cactagaaattcacaaaggcaaaatgaaactggcaggccttaactc attgtgcttctcat[c/t]gtattggaaaagaatcattctttgctatgagaatttggccactctttttgaattaaaatt/ c/-/3316/9/rs2296170/9793954/[c/t]/atacaagagatctagattttgtttagtgtttcactatctcactagaagt ttatgggtgcc[t/c]atcttaactgagttctcttactggagcaatggaacaagaattatgcccacattgcttcat/t/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3317/16/rs274536/75901777/[a/g]/tgataacatagggtttgggggtgctctaaaagtacttcaggacagtag tatagacacagt[a/g]gaagacattagttcagtctggggaaatcatttctgaaatgaggaaactgggaccctgatc/g/ 50 (243) JP 2010-88432 A 2010.4.22 ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3318/20/rs6012504/46695956/[t/c]/tgtccatctcgctctcttcactgaccaggggcagggaggaggcctcc tcagccaaggatg[c/t]gtcgcaggacccacccgaggtgggctctgtgatggtggacagcagcctacggaagcaaag/c /PREX1/phosphatidylinositol 3 3319/18/rs2726346/8768916/[a/g]/gaaattctgccccattgtgaaatgaacagcatggagttgcattcgccc tgagggtaaaac[g/a]ggccaggaacaggagctgctgctccttgggcgcgtgtcagaaaccctggtacctgggatg/a/ KIAA0802/KIAA0802 3320/1/rs1193158/7532091/[g/t]/agtcatcccatttctgacgcctttgctgacagccaagcacaggttctgt gggcaccaatc[t/g]ggggaataaggatgagggaggtggccaaggggttctgtggtggcaggagaaggtcaaata/t/C AMTA1/calmodulin binding transcription activator 1 10 3321/4/rs11096766/34867559/[g/a]/ctgttgcaaagcctgttttcccactgatgagttttgtgaccttgatt acacggtcttcta[a/g]agagtcacatatgagatttttgtataacatttcctacataaatatatttatagagcatgt/g /-/3322/3/rs6788905/183980377/[g/a]/aacaaacaaacaaacaaaaacaaaaagaaaacttcttggctctgtga cttgatgccagac[a/g]tatcttcaagagatctgcctcttctatttccaaataccaccctttcaccatgaccacagt/a /-/3323/17/rs1531565/70621739/[a/c]/tagaatatttgtttggcataataatcttctagaggagctggcatcac tcggggacctggg[a/c]aactggggctcctgccctggcttggctttagcaggccccactctggtcctctgtggggca/a /ARMC7/armadillo repeat containing 7 3324/5/rs289028/114140800/[a/c]/cttttcctcatcttcctgtcttcctctgaaccctctaaattctccctc 20 tgctcattaccc[c/a]cagttccaaagccacttccacattttcaggtatttttataacaacaatcaactccttggt/a/ -/3325/9/rs1408118/9848060/[t/c]/tataatgaaccattatctatgtcaaaagattcactccttaacaccaatc agaacttgata[c/t]tcttttcctttaaccagacattcaggaactgtgctatatagtctgtgcaattgttttagt/c/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3326/5/rs289034/114150064/[t/c]/aggtagttcagttagcaactcaaataaccacagaagtgcttttcagag aggctaccgttg[c/t]acttcagtatgcagcagatacagaatagcaaatgccatgtactcaatggtcaatatttaa/t/ -/3327/6/rs560084/109197042/[t/c]/ggacaaccaaaaaagcaaaagcccgcttcacagccacatccagtgtct aaatccacatca[t/c]ctaaaagtacctggaagatcataggcttcctcgtcaggtcctccaaggccacttccatga/c/ 30 -/3328/5/rs905221/81892293/[c/t]/tgatttgagcagtcgggaaaggcatttagaagagctggcattctgccac caattctatgg[c/t]ttggaagtacccttaaaattaatccttactctgttttcattcagtattcagcactgccaa/t//3329/4/rs2290579/25378425/[g/a]/atatttcggccaagtgaccaacgttgcctccataaaacccaattcatt atccttaacctc[a/g]gagcttctactctgagaagaatacatttacttactggcctctcctcacagatgtgtgcta/g/ KIAA0746/KIAA0746 protein 3330/13/rs9530138/72496866/[t/c]/ctcctcatcctctagatctcaggtttctgatatacacacacacaaag cgagaaagcagat[c/t]gcaatataagatgttaggggtttttgggggtgttttgtttttgagacagggtctcactct/c /-/- 40 3331/4/rs3796404/5663506/[a/g]/tgcctcctgtggaacttccttaagtatctatgaatgtgtggcaagtaga ctaggatgggt[a/g]agctggaaagacccaggtttcctatccaaatggacgtggctttgagttgcaagagtcaca/a/E VC2/Ellis van Creveld syndrome 2 (limbin) 3332/19/rs9676752/35750907/[c/t]/gggttttctgcttttgcccttttagaaacgtcaagctggagaagttt aaagagataaaaa[t/c]ggcaattgtgcagacagtaggtagcattttggttttagaatcattaaatacataaaccca/t /-/3333/7/rs7785682/14389625/[g/a]/catgaagtccaaatcattttagcttaaagaaaacagacgtctattatt ttttcacttaga[g/a]taagtcaggaagtgtgtagtcttatgtgttggctttccagtgtcatcaggggcccagatt/g/ DGKB/"diacylglycerol kinase, beta 90kDa" 3334/19/rs1637656/3113909/[t/c]/gtacaccgggtgcgtggacggccccgagggcagcaagaagggcgcacg 50 (244) JP 2010-88432 A 2010.4.22 atcccgacgcct[t/c]ttcagccactacacatgtgccacagacacacagaacatccgcaaggtcttcaaggacgtg/c/ GNA15/"guanine nucleotide binding protein (G protein), alpha 15 (Gq class)" 3335/1/rs519424/174116521/[g/a]/cccatggttgtggtgaggatttgaggagataatggatgtaaataggta gcgtgtcattag[a/g]tccttgaggagggctttgaggacccttttcttactgagcctggaggcaaccacagaaggc/a/ -/3336/9/rs11143040/73765001/[c/t]/gaggagggaccagggaatggagggaaaatgaacaagaatcctgttga ctttcatagacaa[t/c]acagataatcccgggctgtctttatatgtcctgtttttttgttccacataaattatcatt/t /C9orf85/chromosome 9 open reading frame 85 3337/6/rs4454147/99682595/[t/c]/tggttgaggaactaccaaacagttcagtagcttgcttttgtttgtccc cagagcccataa[c/t]cttttcacgaaattgtgtgattccactctcaatctgaaagacaaatgctgtaggttagat/c/ 10 -/3338/5/rs1351637/44477460/[g/a]/aggaggacttggccctcaagcaggatgacagggcctttgcctctcttt aacatcctgcat[a/g]ggaaatcttttaaacaaagagtagatcccagttgcttgttttgtacttaaacctcacact/a/ -/3339/3/rs3896909/114765968/[t/g]/ctagtcttccgactccagggctgtacttgctagaagggcagtttcat ctgtcattcctca[g/t]tcccctgttgaaaaagccttcagtggctctgaagaattttcagatttaccccaaagtaac/g /SIDT1/"SID1 transmembrane family, member 1" 3340/3/rs4682496/114773581/[a/g]/tggagaatggatttgaagaggacaaaacaggatgcagagaagttaga aggctgatgcagt[a/g]gtcaagataaataatgaggaggtgaattgaaatattaggagaggtgaaattgctgaaatt/g /SIDT1/"SID1 transmembrane family, member 1" 20 3341/3/rs2271492/114785183/[t/c]/taaatgatattttgtagtatcgataatacctttagatctgttacttt ctatctttcgttt[c/t]ttttctcaagtatctctcagatgcctttcccatcatgatgatggaaccaacccttgttta/c /SIDT1/"SID1 transmembrane family, member 1" 3342/16/rs12927233/32045466/[c/t]/tatattttgctctgtgttcattctttgatttcagaacttcaatctt tctgaagcgtgttt[t/c]cagtttcgtttgagtttctttagtggaattctgctggtggtgttttgttttttgtctcta/ t/-/3343/13/rs12583288/70297482/[c/t]/gcaaaataaagagctagaaaactttcatccgtaccactaaaaaact tgtgatatgaacta[t/c]ggactgactttgtttgacactttcacaaaaaattctgtcttacttaacccactaacagtt/ t/-/3344/9/rs913218/133185787/[c/t]/tgggccggcagatgcgcgatgagtctcttaagggcctcacagggaaca 30 gggtgaatttcg[t/c]taagcaatcatctatttccctgattagtatgtgttttggttacacaagaatgctttttta/c/ -/3345/13/rs7323264/93412595/[g/a]/aacccttaagcatttgataaggttcttttgttgaaattaattattga taagaatggtcgc[a/g]tgaaaggatacagaaagagagatgttgtgaaagttaccccagatcatttaatttagtaac/a /GPC6/glypican 6 3346/5/rs2339745/172292640/[a/g]/tttgctgttgattgacaggggtgtccccaggaccccaacactcaaag tcatggagaagac[a/g]ccaggccttagtgggcagcagagcatggtcagagtctgcagagtgggatgacccagcaat/g /ERGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 3347/4/rs4558873/7465939/[g/a]/tgagattcgaactattcatatttgagataaatattctcactagtcttaa gatgcaaatat[a/g]tacgtgatttataaatttagaattccaattgaattatgtattaaacatgttcttatgatc/g/S 40 ORCS2/sortilin-related VPS10 domain containing receptor 2 3348/13/rs4145222/70273320/[c/t]/gaatccctacttctcaatgggtggtgcaaatatttagagtccttggg gtatcactacttt[t/c]gtattttcatataaaatagggaaacaaaatatactacatatgaaattaaagctagttaat/t /-/3349/20/rs12626044/1890718/[g/a]/aagtgggatgtgttgggaatgtctggggctctggtctgcaaggatag tacacgtgaggat[g/a]taagagccagacaagcctggagaaatagcatgtgccagatgataaagaatctgtatgcct/g /LOC727993/hypothetical protein LOC727993 3350/4/rs1028000/54155288/[c/t]/acccctcaagaatgaccagttgtaactctctatgacatcttttatggt catttttctctg[c/t]aacttctgcggcctatcactttaaaatctgaaaatttaatccgagtggccataagaacat/c/ -/- 50 (245) JP 2010-88432 A 2010.4.22 3351/4/rs4697614/25368093/[c/t]/atacaatagtaactttgtggcctcccaccggccaggaatttcatacac ctctagaaggat[t/c]cccaccctgtgaagaccaccctagggataggagatagcatgaccaacagcaccaggaggg/c/ KIAA0746/KIAA0746 protein 3352/4/rs7684332/90294407/[t/c]/taggatttctaagtttaaacttcaaaaaacatacacttgcctgttgtc ttctggattcca[c/t]gataaatacaagcagataacacctatgattaagctatagctatacaatcagttttacagt/t/ -/3353/14/rs1957820/96195906/[g/a]/ttgataaatgatgggatggatagatggatggatggacggacggcaat ccagggattctca[a/g]tggctcctctctcaccattctcaaggagtcagcatttgcaaatttagtaaatctgcttac/a /-/3354/4/rs2221145/109331202/[c/t]/caagtcatggggcagttctttcagagagacagtgagagtctgtatgt 10 actgaggcagcgc[c/t]gggggcgcttggttcctcacccatcatgcaggtgagggagtgagaggaattataaatgac/c /LOC644993/hypothetical LOC644993 3355/15/rs8036994/95134814/[a/g]/tgtttggtcaaaaccagtccatcataactcacattctgatcatagcc aagtcataaggaa[g/a]tgacaagatcagccataagtaactcgtcaccaccttgtgctgggagaatgttgctgagaa/g /-/3356/3/rs9861748/184013149/[a/g]/taagggatatttactatcatggttgaattatggccaaataggacttg cctgatgcagaaa[g/a]tccacagtgaagtcccaaatggatgaagttgatttctaaaaattgtgtgaaatatacata/a /ATP11B/"ATPase, class VI, type 11B" 3357/10/rs10788575/89758564/[a/g]/gtaatcagtagcagaacagtaaaagtaagaagttaccatttttacc ctatagttgatgaa[g/a]aggcattggagaattttgaggaggatcttgatagctgatctgatcacttgctcattcact/ 20 a/-/3358/2/rs10165056/4733888/[c/t]/tcattcccacctccctttcagagaagagaatggcaccctcctgccccc tcctcttcccct[c/t]agtatgtgagtggagatgaacaggagagaaagcagctggtgaaagtcaagctggagtggc/t/ -/3359/8/rs1521826/84248116/[c/t]/atatttatagcagtttggtcttaacaataaataaatcagtaacagata tgccttctgctt[c/t]tgtcctaacaacttggaggaaaagagccagtaaaattgaggcattgctctgatgcatgag/t/ -/3360/20/rs2273534/55718946/[c/t]/tggagaaagggggaggaagcccccaagatggatcacccattgcctgg tttcgcaggagac[t/c]gtccgccttcagttctccagcagctcggggatcatggcccactgaacccccaagcgcttt/c /TMEPAI/transmembrane 30 3361/7/rs6950165/7946880/[g/a]/aaatgtatggcacattcaaaatgggtaattaagaagactttagttaaga gatcatttaca[g/a]agggtttagggaaggcaacaaaggataatggtacagtatctcagggaacattactgcttt/a//3362/16/rs9923392/79178112/[c/t]/aagttccttgggggccatgatacataactcttgggttcattgtgagg aatcatgatctac[t/c]acagatggtatgctgactatgggacctgatatgttacatataggcaacaatggtgctggt/t /-/3363/13/rs1415736/93444937/[t/c]/atgagtgaaagtgttagtgctgtgactgaagatagtggttctgtaag gctgactctagtg[c/t]tctctattgcttgtctttgagtttaaagaagagagtttttcccatttgtttagctgtttt/c /GPC6/glypican 6 3364/20/rs2206698/1885475/[a/g]/acagtgcacctgtctgcttatttccttaggatataatgtgctaaatgt 40 gaaattgctgag[a/g]aaaattacatgagcatatttaaaacttttgatatgttttgctaaatggccttccagaaaa/a/ LOC727993/hypothetical protein LOC727993 3365/2/rs10196277/148904845/[g/t]/aataaaatgaaaaatcaaccttaaactctaaacaacttcatcattt caacatgaaattca[t/g]attctcactcacaaacaattaagtattacttttgtaacagcaagaaaagtcctcttaccc/ t/-/3366/18/rs2337069/44374938/[a/g]/tgtttccaagtgaggagggaaggggcagaggccgggatggagggagg gttggaaagtggt[a/g]gctggagaatgtgtgaggactcattccagaaatccctacgctgccctaaatgccaggccc/g /KIAA0427/KIAA0427 3367/12/rs7485690/24821806/[t/c]/gcctggtgccaagcattagacaaataagacatggccctgtttatcgt agaataaatgcta[c/t]ggcggaaacaggtacagagtactctataataccaatggggtgtcgcactgttaggcaggc/c 50 (246) JP 2010-88432 A 2010.4.22 /-/3368/22/rs2331331/25540985/[c/a]/agaggtcttcaggatgttcgttcttaagattttctcttctgggacgt atccaacatctgg[a/c]gttcaggtcacagctgttccaggagcatgagtgccatccttcatttgttcgccagatgac/c /-/3369/8/rs12680888/84259763/[t/c]/aaaatttccacttctaccctggacagaaaatattagcactttgctgg tttcctttttact[c/t]ttcctttacagattaagtaatagaaatagagtgaaactattgaaacttagcatatgcctt/c /-/3370/2/rs6751715/56216881/[c/t]/gcagatttggagttctggtgagggtccacttcctaacagacagccatc ttctcactctaa[c/t]ctcacatagtggaagctagtgaagcctttatcactagagggaaataagggtgaggttttg/t/ -/- 10 3371/22/rs708451/48137327/[t/c]/ttgcagaggcatggctggagaggaatgctgcctcggcatggctctggc ctcggcctccct[t/c]acttttgatttaggcgatgttaaggcaggctctgggttttaaccctcacagcagctgggg/c/ -/3372/5/rs1004531/118632922/[c/t]/tgtaaccgcacatactggcgaaagcactgcccgggttatcagggtgc cccagattgcaga[c/t]tgagatgctggcctgagattgtaatccaaccttgcattgtaaaacgggcagagaccagag/t /TNFAIP8/"tumor necrosis factor, alpha-induced protein 8" 3373/16/rs8059275/75947457/[a/g]/tccggtcagtgtgggagacatgatattgccttcagcctttctgcagg gattcccttctcc[a/g]tcgtgaatcataccaaagctgaaacagaatgaagaaaacaaaatcctgctttgtgaaccc/g /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3374/5/rs871097/168140685/[c/t]/ttggtgactgcactgcttgtcaatggctgtgggttgtcatggtgattc 20 ccgatgcaagag[c/t]aaccaggcatgcagcaacaccattgggcggcctgtctgaaaaacaagacctctttctacc/t/ SLIT3/slit homolog 3 (Drosophila) 3375/4/rs730469/5675571/[t/c]/caccgtgctcctccatcaggctcctcttctggtgcaggtactggccggca tcctcaaccg[c/t]tcggaaggcctcgccgacggacgcctgctccctacgctgctccctgtgctggagtttcag/t/EV C2/Ellis van Creveld syndrome 2 (limbin) 3376/3/rs2729277/2103834/[g/a]/gttttgaatttttttgctagagtaatagagaactgatacaaccccaagt gcagccaatat[a/g]taatttataaacaaaggaaaaatttaaaaattttcagaaaagtaatgtaagcaagaacga/a//3377/9/rs10512050/77492428/[t/c]/atgtgacattagatttaaaattaaaactgtgattgcattaccctata tattttcatacag[c/t]ggaaacataaagaggaacttgctcaccatgagagatatccaaaggtgaacactgttacaa/c 30 /-/3378/20/rs6019360/46723163/[t/c]/tgtgtgtgtaaagcccaccctctcccctgcccatccgctggaaagcc ccatggcatcttg[c/t]gtgcccaaggagaaagtcattttccccatacattcttgcccatcttcccatctccacaaa/c /PREX1/phosphatidylinositol 3 3379/7/rs722243/10196653/[a/g]/gctacccacaccctgtaatgtggtatagaaaggagtgcatcagtttccc ttcaaaagtca[a/g]gtgaatatcacaaaaacatacaccctcttgctgggattccaccaaagagtgctgcctgct/a//3380/7/rs10236225/10192955/[c/t]/aaatatgtcattctggtgtttcagaaaagagcagaagcagaaaggtc actctcaatttcc[t/c]cttaccctttccttcctgaagcaggacatgaaacatagaaagaattatctgacctccttg/c /-/- 40 3381/5/rs6864076/168794181/[a/g]/gctcagtttcctcttatctaaaatggaatacataatatttttgtcac agatccattgtga[a/g]gaactcatgaaagggtttcatgaaagtactctgctatcataaagtgaaactgaaaaatta/a /-/3382/16/rs1948717/75960655/[t/c]/aaagaatgtaaaagttcatgaaacaaaaagttggttttttaaaaaga taaaattgacaaa[c/t]ctttagcttagactatgaaaaaaagattaaaataaagtcagaaatgaaaaatgtgacata/c /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3383/3/rs7621788/67710891/[a/c]/aaagaaggcaaggaactcttcagagcctcagaaagtggtatgcagcca ggtacaccccta[c/a]tgtaaaggggcatccacactaccagccatcatgctacatattttatatgcactttctcat/a/ SUCLG2/"succinate-CoA ligase, GDP-forming, beta subunit" 3384/13/rs9529809/70266204/[c/t]/tttgcttttggcctgcttattctgagtttgttatattttgtattgtt 50 (247) JP 2010-88432 A 2010.4.22 tgaggattgccag[c/t]acaattaatacaacaattaatagggcatcgcattcttcactattttatgcaggatatgat/t /-/-/ 3385/2/rs2868993/56189483/[t/c]/gaattagaaggaagtgattgacttacaattacactgactagggatcct ggggtttgtgac[c/t]gctgaaaattactcaggtagccctagagcagcaacaaagcccccaaagcccaatgctcca/c/ -/-/ 3386/5/rs7714385/24536402/[c/t]/ttgcatattatccacttgttcgtgtaccacgaggtttagcgttcaggc cctggggtctaa[c/t]atagctgctgctttgattcccaagttcaccactcatttgttatgttactttggccaattt/t/ CDH10/cadherin 10/ 3387/2/rs1990649/149904345/[a/g]/gttactatgacgtttttactcttatcaggttgctacaataaaacagc tagacagataccc[a/g]aagtcaaattctcatgcacagttacaagtagagtgaatttgcattatttttcacaaaaat/g 10 /LYPD6/LY6/PLAUR domain containing 6 3388/17/rs11652957/42774138/[g/a]/gatggaaataatatactgtgatttatttcaaaaataataagggatg ggaacagggatggg[a/g]tatagatggaataggattgaccactgttgaaactgggtgatgggattctgtatacttttg/ a/C17orf57/chromosome 17 open reading frame 57/ 3389/1/rs4266889/205372293/[a/g]/aaaggagacttcctccagtttctctggtaggagacgcacctctttta tttgtggaaatga[a/g]tgagggactgaacgacaagtggatactatattatgagcctcagtggaacagacaagagag/g /C4BPA/"complement component 4 binding protein, alpha"/ 3390/1/rs4571969/205372211/[t/c]/catgagatggcagggcttcctgatctgcctctagaagacaaatcctg actcgtgactgag[t/c]attctcacttcgtaaggatagaaaggagacttcctccagtttctctggtaggagacgcac/c /C4BPA/"complement component 4 binding protein, alpha"/ 20 3391/1/rs4844573/205371523/[c/t]/agccctagtaatagcgtccttttgttcttcttcttcttctttcatga gtagatagttgta[t/c]taatttaccagacattccacatgcttcctgggaaacatatcctaggccgacaaaagagga/t /C4BPA/"complement component 4 binding protein, alpha"/ 3392/5/rs28825/109278529/[c/t]/cttcttttcttgtggatctcctccattctccacctcacaagtccagccc ttcttctgctc[c/t]tacaccagatatgcttgcagactttaggactggctctgacttttctgaattcctgaacca/c//-/ 3393/7/rs6948511/27945240/[c/t]/caccatcactgtttagcaagaaatctgaagcttgggccatttctctaa aacaccttgtgt[t/c]gcagagccaagtagcagctggccatgaggtctacggagcacagagcaaaccttcctgctt/t/ JAZF1/JAZF zinc finger 1/ 3394/13/rs9573083/72478964/[g/a]/gttatatattaacgttttagctggctaattctgggtgacacagaagt 30 atctatcttatca[g/a]ttatttgtttccaaaatcaccttgtaacatagtaaattacttctggtaagtttccagtta/a /PIBF1/progesterone immunomodulatory binding factor 1/ 3395/10/rs2986032/105220322/[t/c]/atttcttcccttgagatgctctgcaccctccctccatctttctttc cacatgtccaaatc[t/c]ttcccatccttaagacccattcaaatggcaccttcattgtgaagccttccctcaccctca/ c/-/-/ 3396/11/rs7125155/104322127/[c/t]/agtgactgtgctggttctggatggctttcttctataaacgccagag gtgtatctttcttt[t/c]cccgcaggagttttactgttctctacaatttttactttattaataattatactattctgt/ c/CASP4/caspase 4/ 3397/3/rs1626115/4375312/[a/c]/tcataattttaaagaaaaccttagcaatatatgaagaccttcaggaaaa aaaaatttaat[a/c]ccatgaaagtgccttcttttagtgcatctagtgatttatttagtggcttcaagaactgct/a/- 40 /-/ 3398/6/rs566575/109188290/[g/a]/agcagccccagtgcactattgaagataaacagcttccctcccttcact taccagagtggg[a/g]ctgcggttcccctggtcttctctgtgtgggagcagcagtggattctgcccagagctgtgg/a/ -/-/ 3399/14/rs746985/96197184/[c/t]/aggggttaagaacctgcaggggcctccaggcccctgctctagccctaa ggcagataac[c/t]gttttaataccctcctgattgttaagtattttcaagacaaaccctgctaaagagcatgga/t/-/ -/ 3400/5/rs289027/114137000/[a/g]/gagctccccaggaactcccacacatctaacatcctgcagttgcacaat actgctgttgga[a/g]cttttggctaagtggtctttcctgaatgtcctttccattatgtctccatagttatacacc/a/ -/- 50 (248) JP 2010-88432 A 2010.4.22 3401/18/rs608916/8753794/[a/g]/catcggttttctcctggtggtttgactcatcctataaattgt[a/g]tg tgaaatcacttttgccattggctcttggcatacttaattgcattgtggaaaatctgac/a/KIAA0802/KIAA0802 3402/2/rs881455/71961334/[c/t]/attttatccatattcctggtctccccaatatctagccaaagggctgcag tctaccttctc[c/t]gcttcagcgagaaaaccccaggtcaggaggggcctggtgcagtcaggttctgtctccacc/t//3403/1/rs1188414/30872516/[a/g]/tcagtttctgcttggcctatgagaggacagagaacctccttgggttat agtgactacagg[a/g]tttacttgtggctttaatttatattacagatttttttttttgacagtgtcttgttctgtc/a/ -/3404/1/rs665053/30879254/[t/c]/gtgttctcaaccactaccctacaccacctcctttggggaatgatggtga cagcctttctg[c/t]gggctcctgtgagctcactgtggcctcccttggctccttacccagacaagggccttctca/t/- 10 /3405/4/rs2276953/25369926/[g/a]/ctcctggttctcctgcaaataaatttctcagatgcatatatttaggga aacaattcatca[a/g]tgaagatgacaaaaccatctggctctagagacttaaaaaaaattttagaggttgtaaaca/g/ KIAA0746/KIAA0746 protein 3406/9/rs10991561/106957453/[c/t]/acgatactaagaccccagaagagaaagacctccagcacaggagatt cagctgaagactct[t/c]tgctcctctgatgactgaaaatggaccagggagcatgtgaaagactggcattggaggaga/ t/-/3407/7/rs12702681/7938258/[t/c]/agcagatttagctttggaaagtatacttaaaattctccaactgctaga tctagacagaga[c/t]ggtaaaatctcagtaaacttattctggcagcttgttacatggtaactaacaaagaacacc/c/ -/- 20 3408/13/rs3829382/27475688/[g/t]/taaaagcacacgtgctctggaaggaatgtgtaggtggctatgggtgc acaatttcagggg[g/t]ttcgtgaactccagttaagacttgccctaattataccatgtaaataattcaataatgggc/g /FLT3/fms-related tyrosine kinase 3 3409/3/rs12696498/184003837/[t/g]/tttcttgattgctggtgagatgcaggtatcctcaatttcattcaca tgaatagattgccc[g/t]ttttccattgggtagtttggcctttcctaattcttgctatagcctggatgccaattcttt/ t/ATP11B/"ATPase, class VI, type 11B" 3410/1/rs4847031/105383658/[a/g]/aacattggacttggaagtatgaggcaaaggaacctattgatgcaatt tatagaggtcatc[a/g]tccttgaacagatggcagcataagaagcgatgaagactagaataaaaaattaaacataag/g /-/3411/22/rs761906/45517323/[g/a]/agcaagccagcttaccagcacccaggggagggtgtgcacctgcctctt 30 ctggtgtcttca[a/g]ataaggtgtccatttctcactgatgcaatgcaggcttgactcattccaggtactggaggc/a/ -/3412/5/rs1530498/13955220/[a/g]/tattgttcatcatcagattttattctgttttagaacgagttgcggaag ttcatggatgtt[a/g]catttgcaaagattcaaaacacaaatcaagctctaagaatgttgaagaaatttgaaaggt/g/ DNAH5/"dynein, axonemal, heavy chain 5" 3413/7/rs2280680/129336404/[t/c]/ggtgtaggtcagaaattcacggggtgcttcatcaaagtgtgcatgtc tgatgaataccta[c/t]cccctgcctgcccctctctaggtatcagtggggcggggaatgtcactctcctggtgattc/t /UBE2H/"ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)" 3414/1/rs12060961/17826998/[c/t]/ccctctctgaacctcacttgctccctttgaaatgaggagcatttaat agcaccggagccc[t/c]agggctgctgccgcaaaagagggagctggcaaagtggcttcgtgattgtccttaacacaa/t 40 /ARHGEF10L/Rho guanine nucleotide exchange factor (GEF) 10-like 3415/7/rs12536370/41927385/[g/t]/aaaagaagcgttcagcatcctgattttaacaggatatatttgacatg tctcctaagtcac[g/t]cgggttttatatgaaattgctccagttgttaataaacaggaagttctttattctggaatt/t /-/3416/9/rs1572748/1959329/[a/g]/cagccaagaatatgatgtgccaagtatatgccagtatacgtgagcacac agctgaccata[a/g]cactctcagcagcattcattctcagagaagtgaacaca/a/-/3417/7/rs2107809/10212896/[g/a]/gttttagatcaaaggacaatttttagtattcctcaatgactgtttctt caaccagtatca[a/g]ccacattgtcaataatgcatgaattaaaggggtggcctaataatgtttatgtgaattcac/g/ -/3418/9/rs1333111/9406962/[g/a]/tatttgtttttttccctcaatacaagtactttcacaatataaattgtgt 50 (249) JP 2010-88432 A 2010.4.22 ctgctgcactc[a/g]tagttaatctgggtttctactaacagcttatgtataccaagtaagatcagtgaacaaaat/a/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3419/16/rs7404422/7547113/[t/c]/ttgatacagtctttgtaatgttgttttattttttgctgtgagtccaca gagcgagtatta[t/c]aaacccattttacagatgagggaactgaggtaccatggaggtgaagtaatttgcctactg/c/ A2BP1/ataxin 2-binding protein 1 3420/5/rs686349/113985145/[a/g]/ctgaatgctgttgcaaatgtccttttgagtgagaggcagagggagacg gagattgaaaac[a/g]tacagagaaaaaggccatgtgaagatggagcagagagagacttgaagatactagacttga/a/ -/3421/16/rs8058333/75947263/[c/t]/tatcatcatcatttgtctttctgtttattgacaggtcaaaaggtatt tccactgagtatt[c/t]gtttgcaggtctatggagcacaattctgtcatcactccaaacctaggagcaccccaggat/t 10 /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3422/4/rs2332794/175177675/[c/a]/aagaaagcagttaataaatacagatgtgtgctgctactgcgtactga gaaagcttccatc[a/c]aaccagagaaaacaaatctgaagttaggtccccttcagtgaaaatgcatgactgtgaact/a /-/3423/14/rs2256224/68122500/[g/a]/ggctaggaggtgatgggggtaagggagggctgcaggaagactgattg cagccgattcact[a/g]tgaaacgcaaagcgtaacgtgccgtggatgctttgcagggccttgatgagatctgcagca/g /RAD51L1/RAD51-like 1 (S. cerevisiae) 3424/7/rs833010/136505450/[c/t]/acatcaaggcctccaacacttcctgaaaattcagattctggggtacat ctgataactaca[c/t]tgaggaattgagagatttcatgagaaaaatactgcaaaggagtacaagaactctcagtgt/c/ -/- 20 3425/6/rs1146229/109205720/[t/c]/tgactagtattccatactctactcttagtcacaaaagcaacataaaa atagtgcatagtg[c/t]ggaagggtagacagagattgacttctgagagaggaaggagaatatttagaaggtaatcag/c /-/3426/8/rs10958161/84710007/[a/g]/caagaacaaatattacttctcgctaattttagttctgactccgctct gcatttattttag[g/a]gtgtggctctgttttgtgctataagttgcctgggggtacccgccacataattccttcatt/g /-/3427/20/rs6044970/17660076/[t/c]/tggagtctggtggtgattgaagtccgttcagcacaggtgctcaggac ctgcggacttggg[c/t]agagggcattgtaagcagctagagaacaagagagggcagagacagcttatctctgcttga/c /BANF2/barrier to autointegration factor 2 3428/20/rs6044980/17661719/[t/c]/acaggagggaaaactgaggagggagtgtcaggttgccacttggctcc 30 agaggctgcaaga[c/t]ggggcttcctgtagcattcctggaaagtttgcccagggtccacatgttcccaggcatcct/c /BANF2/barrier to autointegration factor 2 3429/1/rs595191/231890548/[a/g]/aaaggatcagggcacagagatataagaggttggggcacttgccccact cctagaaaagcg[a/g]gatttgctgctaacggtgaaggagaaagggtagagacaatgagagaaggggttggggtac/g/ -/3430/11/rs2509118/102442889/[a/g]/aaaactactcatgactaatgtctttcaccaaactgttacctacgaa ctttctaaagaaat[g/a]tgtgacaaaggcgtgattagtttcatttgctctgccatttttagctgtatatgtgataaa/ g/DCUN1D5/"DCN1, defective in cullin neddylation 1, domain containing 5 (S. cere visiae)" 3431/11/rs1940226/102472129/[c/t]/acagtcactacctagaacactgcttgtcatcatgacagagagaaag 40 aacaacatggtaaa[c/t]cccatgctgcctcttgaggattctgccccgaagtgacacattaatcctgttcaagtcata/ t/-/3432/11/rs1893073/102473303/[c/a]/aaaagtagttcacagaaccaaaattactggcagaggttgtattgtt ttgatgacttgctg[a/c]agagaactctctttttgtttggatgagatggtagagaagaccaaaattgaatggagacag/ a/-/3433/8/rs1464466/84263681/[c/t]/ctacaatggaaaaccaaaacgtttctccactcttacatgtattctaaa aatgatgggtgt[c/t]caaaaagtgttaacatagcaagtctgagagtgctatccttataaaggcctgcttccaagg/t/ -/3434/8/rs1994469/127245317/[t/c]/cttataacaggatactgatctataaaatataagccaaatactgttaa gaaaagttaacca[t/c]gaataagccaggtatggtggctcatgcctgtaatcccagcactttgggaggcccaggagg/t 50 (250) JP 2010-88432 A 2010.4.22 /-/3435/19/rs4801959/58361085/[t/c]/tgttttcctcgattattaggagacttctcaacttgattgtattcata aattttcccttca[c/t]gttgaaattgctgcagttcagggagatgtgactgaaagcttactccaagctgattttcaa/t /ZNF665/zinc finger protein 665 3436/18/rs9948128/5882517/[t/c]/atggtaatatgagggtttgaaatgaacaatggagttccaaccattagt aaaacctaaatg[t/c]agggactcaaagtagtggttaaggacctccctgtcaagattctttccctcagtccttcag/t/ -/3437/10/rs10509412/89589334/[c/a]/tgaccatcaagagaaggacaagtccttataattggagtggaactgg actagaactaggct[a/c]ttgtctcaagtgggacgaagactctagaatagatcagtgagctttgtacctaaggcaatt/ c/CFLP1/cofilin pseudogene 1 10 3438/10/rs11238778/43742560/[a/g]/tgaatgtccacccagcactctaccaccagtgagaacctgcgtgctc atcagacagatgcc[g/a]ctccgtctgcaggacacttcctgtgtctcagtccattgcatgtcccgtgggactcactgc/ g/-/3439/2/rs2111469/56229812/[a/g]/aaaaatgcaaaatgtatccagtgtgatggatggcaatatattttaaaa catacatgtgct[g/a]aaactaaaggtgacccaaaaatgagaaatccactccaggagacagtcttcatcactggag/g/ -/3440/3/rs10511292/112452382/[t/c]/cccggccactatcagcaatttaagaaaatgttattttccccatgac ttgagtgaaagctt[c/t]ttgtctggtttgtagctttgtggctgacacaaaattgggaaaaatagaattcacaatgct/ c/-/3441/19/rs376047/11237675/[g/a]/gtacagcccctcctccctggtccaccagctccagcctcatgtccgcaa 20 cgtgttctccac[a/g]cagtagagcagaggaggccaaagtccccgccaccacgctcagcctctgtttgatcagctg/a/ -/3442/9/rs7873669/9876403/[c/a]/agagtaatatgtaatgaactgcaaatagctttcttcacatgtggacata atataaaggat[a/c]ttagaccttgagcccgaaactattgccataaaaaagggaggtttaaaaggagagtcctga/a/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3443/7/rs11769443/38323600/[c/t]/gtccaaagtgattgggggagcaaaactacttacgagccccaaggact gccagcgttgatg[c/t]gtggagcagtgacagcatgtctgcaggcactgtgctttctgccagggcagcctgaaatca/c /TRGV9/T cell receptor gamma variable 9 3444/8/rs7000796/135733855/[g/t]/taaagtgtattctatagcagaaaaaaactcatccatggatggagatg gaatggatgcaga[t/g]ccaaggactgaagagccggaaagtcataaatatgtagctaaatctaaatgaacacttact/g 30 /ZFAT1/ZFAT zinc finger 1 3445/4/rs4541476/46290996/[t/c]/acatatatatatgtatgcctaattctttattcctgggtttttattaat ctctaagcccca[t/c]agatgtaagcacatatttgttttcttcaagtatgcccagtgcaaaatgctttgtaaaatt/c/ -/3446/2/rs11563056/234565909/[g/t]/tggacttcatttatgtacaaagtgatctgaattctaaacgtctgtt ccctcttggtacca[t/g]ttccactctcagtgagtttctgaactgctgtccctctgcatggcctctccttcctcctcc/ t/TRPM8/"transient receptor potential cation channel, subfamily M, member 8" 3447/2/rs11695247/234564012/[a/g]/cctgggggtgtgttttttactattataatgagcacaggtcagccca aggacactaatcac[g/a]ggtttctgtgcttgtacaaatgtggggatttttctcttctgctcctgcctttttgctgta/ g/TRPM8/"transient receptor potential cation channel, subfamily M, member 8" 40 3448/11/rs2023642/113189425/[t/g]/agttatcctttctttcccaaagttccatgattcttcaagatcttta atttaacaacatgc[g/t]ttcaagctttatttctgtaataataaattccaaa/t/USP28/ubiquitin specific peptidase 28 3449/4/rs3733553/82333527/[t/c]/ggatttgattccaacttctgccacttactaactgcggaaccttaggca agtcactgaacc[c/t]ctaagtttcctcagctgtaaaacaataataaacagagtctacaggtcacagatttctatg/c/ PRKG2/"protein kinase, cGMP-dependent, type II" 3450/20/rs966248/55698643/[c/t]/taaccttcccacctgcctggctttcagcctgggggcctccatgtggaa ccctccctgcct[c/t]tgccagctgggctgacagggaggccagagaggttcccaagcaagcctctgacctcacctc/t/ TMEPAI/transmembrane 3451/21/rs2834719/35284075/[t/c]/agactccctgggctttgcctgccacatctgtacactggggagaaggt 50 (251) JP 2010-88432 A 2010.4.22 ggattacctctta[c/t]gctccaagtagcaagtcatttaacctcactcctcatgggttggggacgggagcatgctca/c /RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncog ene) 3452/15/rs4774684/52212698/[a/g]/aatttagagctagaagatttagatagatgctggtcaaatattcttat tttacttatatat[a/g]aaggaaaactgagggttagggagatgacatgtttccgtagattacgttcagatttacttc/a /UNC13C/unc-13 homolog C (C. elegans) 3453/2/rs10490573/204291408/[a/g]/ctctgtggtcaggagggaggtgctcttctatgccagggaaatcagc atcaccttcacagt[a/g]tgctcacaaatatcacagggcaaaatggctgaaagtagaagctttcattgtttttggttc/ a/CD28/CD28 molecule 3454/2/rs1181389/204283135/[g/a]/gacaaaaacatccagtcaatttcttttaacagaaaaactggccacag 10 catattggaagtc[a/g]tgtaaatacggcaatctgttgattttttgacattcatcttttcaccttactttcccaagc/g /CD28/CD28 molecule 3455/16/rs11117255/85751695/[g/a]/cggccccaggggcactgggcggagctgcccagccagacgccctctc tgggattgctcgtc[a/g]tgcctgcagggagctcttccctctttccggcttgtcctggaccttctgctgctcaggtgc/ a/LOC730018/hypothetical protein LOC730018 3456/4/rs749148/5659316/[a/g]/aagcatgcaaaaaagcaggaatataagatccataaaccagagaaaaccca atcaatagaa[a/g]tgagagagacggtggaacaagcagataaggacattgaaacagcaattagaaaaagaaacg/a/EV C2/Ellis van Creveld syndrome 2 (limbin) 3457/1/rs12121907/168899432/[t/c]/acaggagtgcagagaggggggaacacgttttcttgaagatgtttta aagctggaacaagc[c/t]ttcttctgttggtgcttgaactcttgcctgggaataacttttttaacctttaaaaaaacc/ 20 c/-/3458/12/rs708354/129040137/[g/a]/agacagcataagtggccacattgggatgtctcagttcaatgatctaa ccagttcaaacct[a/g]ggcttatgagtctacattgggactgacattctatggctttgctactgagagaatgtgctg/g /-/3459/11/rs1954850/101883770/[c/t]/gtggttctttttaaagttctctttttccttaatttcttaggcattg atctaattatgtac[t/c]gtggataactcaattttctgtattttgggagtgacttgaatgatttaataatttgaatat/ t/-/3460/5/rs7704111/118635241/[a/g]/ctgctttttcacagaggggaagggcataggggctattagtacaattc cagtgccaggggc[a/g]ttgactttggcaatggcgacatgcacaggggccaatctggataacaaagtggacaatttt/g /TNFAIP8/"tumor necrosis factor, alpha-induced protein 8" 30 3461/6/rs6934392/97044948/[a/g]/tttggtggtggcaagaatgagagacgctgtgggatcctgggggtaagg aaggtgtgactg[a/g]ttgaacagagcacattaatttaagccaagtaagctacaccaaggggtttggtatccaaag/g/ -/3462/11/rs2862996/43610409/[g/t]/cttgtcttcatctatagagtaaatgaattgaattagatgatctctga ggactcttccaac[g/t]tgaagaccaatgcttccagtactaggcatgtaaagctaattgggagatattttttaaatg/g /-/3463/2/rs163521/44985147/[c/t]/ctcagggtttcatgtcatttgcatttggattgcctaagatgtcaatcag ttctagccacc[c/t]gccaagaaagttagaagccaaagacttttttttttttctttaaggaggggaaaagggagc/t//3464/11/rs7116578/127893983/[g/a]/tggatgtacaccctctgctgagggcgggtggggtgagaggctgatc 40 cttttattcttata[g/a]aacagcaagtatccaggattagagctcctgctcttatctggacattaagctcacctcacc/ a/ETS1/v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)// 3465/5/rs1007984/52672653/[a/c]/tatgaaaagcctcagctcaaattatttccctctcttccaactgtcaca ataataatcagt[a/c]aatgaaaacatgtaagacaataggcttctaaggctggtgttaatggtgattttgatttta/c/ -/-// 3466/5/rs645574/175040069/[g/a]/gacaggcttattccagtaagccaaatatccctgaggtgtacagaaagg gccaaaaatcag[a/g]gccaccacacacctgagcccctccaccaggaagtgactgctgctgactgtttggtatgtg/a/ -/-// 3467/1/rs2940252/205640010/[c/a]/ctcgtaattcatcagtgatactgaagcctttatgtcatggttggttt ccctttcctcatc[a/c]aaaaacttactaaagaatagaaagcatttataataagaaagaaaaatattcattaataat/a 50 (252) JP 2010-88432 A 2010.4.22 /-/-// 3468/3/rs12631548/56011031/[t/c]/ggtgttttcgagcttgaagatattccagtcttatttgtctttcttca catctccactgtc[c/t]tgagcctgcttattagcacttctattcaaatgttaagggaaaagaaacttaagctgatta/c /ERC2/ELKS/RAB6-interacting/CAST family member 2 3469/3/rs1708479/165649779/[c/t]/cccactacattcctctcctgacattgggaattacaattcaacatgaa atttgtgtgggga[c/t]gcagagaaaaaccatattactgtcctcctggtccctcccaaatctcatgtccttctcaca/c /-/-// 3470/16/rs4784182/60912752/[t/g]/gtttcttagaatattcattggggatttggtataacaacctcatttgt aaaggccaaaggg[t/g]atggaagaggaagggagcagttaatgagtgataggtgacaagtcaaggagaaggtgctgg/t /-/-// 10 3471/10/rs10886094/119273698/[a/c]/cccccatgactgcttttgcacccaccatactggaaacctcacaca acagacctggcaaag[c/a]gggatgggtcagttaggaagcaggaagatgcatcacttcaaagtacaacaacattagctt /a/EMX2OS/empty spiracles homeobox 2 opposite strand// 3472/15/rs16956762/29539275/[a/g]/cctcactacttggggcttgtatgggtcaatttctattgcctattgt ttctactagttttc[g/a]tttgtgttgatttgtcttcttgaattcttggttctctttcattttgagttggatattaag/ g/-/-// 3473/9/rs1327291/125807869/[t/c]/atgtttaccaaacccaactccagtcagtgctggctgggcactccagt cgattggtgttag[c/t]gtatgggaagctcataaaagctttatggggaaacctgtgcttagaaatggagtttagagg/t /-/-// 3474/17/rs758152/63822927/[a/g]/tttgacagccatatgggaaagctggccaaatcttgatggattctcttt 20 gctgattcccca[a/g]ttctgcccagccctgaaagaataaggctctagaatgaggaaatctgagtttgaatattgg/g/ ARSG/arylsulfatase G// 3475/5/rs2642749/62137231/[g/a]/tgaggttgagagagagtgttatgagagaagacacagaggacctaatct aggaagactcca[g/a]ttttaacagaataagtagaagagggccaataaaaaaaaaagacattctacttttctggtt/g/ -/-// 3476/21/rs395640/26891730/[a/g]/gtttgccaacgtccatccttgcagatacgtttttaagcacccattcca ctttcagactgc[a/g]tctcctcattctctccatcagaaagtgaacaggaaattaaaactaattttaatattatgc/g/ -/-// 3477/7/rs4410790/17251102/[c/t]/ttgtgaaaatgttgtaactccctttccaatatttgaaatgttttcctt attttattacat[t/c]agcagggaccttgagttaaaagttaaacagttgtcttctagtcaacaatgggcctgcttc/c/ 30 -/-// 3478/8/rs6578225/136307876/[c/t]/atggttgagatatggagtaggggcaagggtttcagacaatagggtga ggagagagagaga[c/t]gacagcttctttagggaagggaaatttgagggaaaaaaatgcttaaggaagaaattcaga/t /-/-// 3479/3/rs7637171/120499271/[a/g]/gacgccacatgcttgagtgggaactttggagagacaaaggctgaaga cagaatgaatgtc[a/g]tatgcttctgtaatttgctgaggctcagccctgctactttcagctggacaaacctgacaa/g /CDGAP/Cdc42 GTPase-activating protein// 3480/13/rs7981142/50487686/[t/c]/tcagccatcccaggagcattaggatctgctgagccagcggaggagga cattcatttttca[c/t]ctccaaaactgttcaacttttagagtgtgaacaaacttccagacttggaagcgtactttt/c /GUCY1B2/"guanylate cyclase 1, soluble, beta 2" 40 3481/19/rs4804528/10747206/[t/g]/ctgtcctgatttagaactgtgccattgaaatggagtaggtagaaggt atctgtaggatgg[g/t]atcctagaaggggagttactggatcaaaggtgtggttcaggcagagtgtcaggcgacatc/g /DNM2/dynamin 2 3482/2/rs1177279/61148626/[c/t]/tttactgaattaacgagaaggtcacaaaaccttaagagacatttaatg tatcctttggaa[c/t]tcactccaaactgcaggtccacaactcatttaaacatttaagtatagatggggatgtgca/t/ KIAA1841/KIAA1841 3483/10/rs1935401/15054375/[t/g]/tatgacttacagaaacaaagtataagattagattttagaatgcttga gcttttaaagtat[t/g]atacccacaagacacatcttacattgcagccttatgctgtaagataactaattcaggccg/t /MEIG1/meiosis expressed gene 1 homolog (mouse) 3484/5/rs1402025/114015797/[g/a]/ctcctttcagatgtctttccagtgcaagaggaagaaaaatttccagc 50 (253) JP 2010-88432 A 2010.4.22 ggtctccattttt[a/g]tcccaaagcttactgagtgcaggttccttttacccttaaatgttttacattgaccaaaac/g /-/3485/5/rs283776/114012455/[a/g]/tttctaaaggtatgaaacattgaaaacgaaatgtacagagaaaaacaa tgaactcagtat[a/g]cattacctacctctatgaaattctacaattttgccatatgtttcagtattatttaaaata/a/ -/3486/5/rs283777/114012141/[t/g]/atataatgatcatattcctcccaatggatgtttaccaagtatatatac tgtcactttgat[t/g]gatgtaactgctaccttgattaatatatagacttttgccaggactccagaagcctccctt/t/ -/3487/5/rs2553482/114006515/[g/a]/tgctctctggcaaagataaaagaagctattagtctattccttcccct aaaaagaaggaca[g/a]tctttcttaaattttaagtcataggtttctttgtggcctcacctttttaatgaatttttt/g 10 /-/3488/5/rs402641/113958184/[a/c]/caagctggatttttccaagtcattcttcagtctctcagctccttcaca gtttagggatac[c/a]ttcttctatatagtcccagttgttttcccctaacagtcctcgagctccacatttgccact/a/ -/3489/16/rs1549666/75966476/[g/a]/tgtttatttgtggagtgtttaaagcattttgagatatcgaaaacaag caaagtctggctt[a/g]gtaacagtgaatgagacagatctgtggtctcccgtggcctccaattcaatgggggaacca/a /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3490/1/rs4658703/243356850/[a/g]/gactcagaggctcatccaactccacggagatcattatcaccacaagt tcttcagacaggt[a/g]tggaggttttctaagggatatttttattttctggattgcaattttgtttaggaagagatg/g /-/- 20 3491/1/rs6586569/17899964/[t/c]/agagcccactgggtttgcagatagatgggctgggaaggaaagagagga gtcaagcatgcc[t/c]ctgaggtctggcctggcgactggaaggtcagagctgccagcttccctggcagggtggctg/c/ -/3492/15/rs1373656/56457727/[a/c]/agtgaattaataacttaacttgaatatagtattaagactaatccttt atccacataacag[a/c]ttccctccaccaaaaaaattagcaattttgtggttatctctttatattttcctcatataa/c /-/3493/13/rs7991311/104054773/[t/c]/ccactcagtaaaacctcaaattcatccttgaagcccacatgcaacc cagttcttccgcga[c/t]gatgggcaagagctcaagatacagaaggctggcacattggccctctgcccttgcaaaaag/ t/-/3494/12/rs2439732/69301398/[a/g]/caaactgggtggggtgatgggagaggagaagctaacatttaagtcaa 30 atttagagttcac[a/g]ttatttcctggagttggtatttttgttaatgaactgagagtaagtattgagttttaaagt/a /PTPRB/"protein tyrosine phosphatase, receptor type, B" 3495/6/rs6914160/53668021/[a/g]/tgcaggccatcagggcacaggtagagtgaggagggctcccactcacca gcggggtctagc[g/a]tggatgtggcagcgtgggggtggcgtgaagggagcatatgtggtaagagaaagtggcagc/g/ -/3496/19/rs8106664/10589030/[g/t]/ctctcagggcagaaaccattagtatttgctgttcccctcccttcgtc cccacccagctaa[g/t]gttaataagagctaatggaacccatcacaagatattaccaatgttccctctttacagaga/t /-/3497/7/rs2972121/147506371/[c/a]/atcttggtcactcagtaatcctgtgacttttattcttcaagtttttt ctaagcaataaac[c/a]aatgaatgtttgagaagaaaacagaactccctaactcagaaaatggtttcagagtgatta/a 40 /CNTNAP2/contactin associated protein-like 2 3498/4/rs1078758/5680199/[g/a]/cccaacaaggttacctagtagcggaaccacagtaaaacaacagattgtc ataagaaagcc[a/g]ctttatagtcatgtccctattcatttcagagctttttgtaacctaaaagaataaattttg/g/E VC2/Ellis van Creveld syndrome 2 (limbin) 3499/17/rs6501760/70619865/[g/t]/ggccttaaaacaggaaggagccagacggaaggctgatgtgggaggat cgttgcagtgaag[t/g]ggagaatggcacaaaaagagtttagagagttcagtggcaccagagcttgcaggagtttag/g /ARMC7/armadillo repeat containing 7 3500/20/rs6020717/48785887/[c/t]/aatcagcaagcactagcaacttcatgttgtgataccagaataaagaa aatggaggagaaa[c/t]tgtgacttttgataacatcatgagactaactgatatgaagggtgttccctgagtttttat/c /PARD6B/par-6 partitioning defective 6 homolog beta (C. elegans) 50 (254) JP 2010-88432 A 2010.4.22 3501/14/rs12433087/25659936/[t/c]/tatgtactaaataattattcctttgtgagttttcacatgctcccac agattcttaacaac[t/c]ggaaccctaaatatgttgctatccatttttatatcaataacaaccaataacctaaaaaca/ t/-/3502/15/rs2077778/27114644/[a/g]/tttggctggactttaatggcaattgatgggcaagtgcaggctgttct tgcaggggaggga[a/g]tgctgcctctgcttgggctgctaggcttggggcctggtcacctggggccactgcccttcc/a /APBA2/"amyloid beta (A4) precursor protein-binding, family A, member 2" 3503/8/rs4243894/135953370/[t/c]/tttaatactttatctttttctgttggacattgagttactgactctca gctccaaacccac[c/t]ctttgctactctgatttatgatgctggggctgggactctgcaaaccacatttctagcctg/t /-/3504/6/rs2295949/43754425/[g/t]/gtgtgagagacaggacctgcgtggagccacattatctttgcacaaacc 10 ccaaaatgatgg[t/g]aatgctggtgaaagtttaccttgggggttcttgtgggagtagctaagaggtttctctgcc/g/ MRPS18A/mitochondrial ribosomal protein S18A 3505/4/rs6849773/5691249/[a/g]/cagtgtcggtgagggaggctgcagtggactgaatggtgacactcccacc ccccaaaaaag[a/g]tatgcctagatcctaacctcaggaccttatttagaataagggtctttccacatgaaatta/a/E VC2/Ellis van Creveld syndrome 2 (limbin) 3506/9/rs3780680/125819315/[t/c]/accctccattcagccatctcactttctctctggcctccctctctctt tttttcctttccg[c/t]tctctccgtcctttctctctatctctgtctctgtgtgtgtcgtgtttgttcccgtgccct/c /LHX2/LIM homeobox 2 3507/14/rs1022590/96630703/[c/t]/cacacagctatgctcatttacaagttattgtctatagctgctcatat gttcaacagtcaa[c/t]gtttatatgttttgtgcttcattggtagagcagttgcaacagagattgtatggcctgcaa/c 20 /-/3508/10/rs10827787/37852963/[t/g]/ttaaagaaatattagaatcacccaagaaggcaaagtcacattgaat aatgagtgacagtg[g/t]gtgctgggtgtcacgctctgtgtcttctctgtgagtttgtcagatggctacttttggctt/ t/LOC219752/similar to transforming 3509/7/rs10215972/129373590/[t/c]/acatcctggggagaataaaagatataggaaaaaagccataaggtta acatttaaggccaa[c/t]agttcttaaacagtggtcctggaccagaagcatcatctgcgaacttcttagaccccaccc/ t/UBE2H/"ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)" 3510/6/rs439205/33281820/[c/t]/aaatactcatgtgggtgaaagcttcttttatggatttttttgaagactg agtctgtgacc[t/c]ttttttgtcttcatttctcatacattcattgaatatttaatgtttgccaggaactgtgcc/c/H SD17B8/hydroxysteroid (17-beta) dehydrogenase 8 30 3511/6/rs421446/33282761/[t/c]/ggggggaggggactggtgctgcagaaccagtggaaaggggtgacgcacg aacccctccct[c/t]caaaaagacccggagtgtcacgcatacacagtgacacatactctttcctctcacacccgg/t//3512/21/rs2833661/32414431/[t/c]/agatgagcaaatggagaaaaccaggcacccagatcttgaggaaccag ccccagccaattc[c/t]gccttgtctgcgtgtaatctatgtctactgcaaaacacttcttccttagacctcagatgc/t /-/3513/4/rs1113094/144179034/[t/c]/taaaatctgaaagagatcaagaccaaaagaaattgagcccaaaatac tagatcaagccac[t/c]ctatttctgaactgaacaccctatttctgaatttctagttatagggaaatataaatgttt/c /LOC729675/hypothetical protein LOC729675 3514/4/rs1104696/144156353/[g/a]/ggtggggacacagccaaaccatatcaatttttactacattcttaaac 40 tttttgacctgta[a/g]gtgcttgtaatactctctaataatccttcggggtttttcgtggcatgagttgtaatttct/a /LOC729675/hypothetical protein LOC729675 3515/10/rs10509532/89727534/[t/c]/ctttgattcagcctaacccttccgattcagcctttgcaacagcact gtttccaaatgtga[c/t]gttattacagagatgtcatacaaaaattgacctatcatgtaggcacaatgcatgcttttc/ t/-/3516/7/rs7807686/83133610/[a/c]/gactctggtacatttcagatgttcatctttaacatcagtgtgtgtgca ccctcaatcaga[c/a]aaccctagaattggttgaaaacttgagtgtgttgggcctcagaaaatgtaaccctggaat/a/ -/3517/12/rs10845677/7717572/[c/a]/ggtaacagagtgcgactccatctcaaaacaaacaaacaaacaaacaa acaaacaaacaaa[a/c]actaattggccatatatgtgcatgaattcattttggaatcctctcattccattgatctat/a 50 (255) JP 2010-88432 A 2010.4.22 /-/3518/6/rs3749855/17391300/[c/a]/cgacccccaagatccatttttgcacacaggtacatttcaagccttgag aggagtatttac[a/c]actctcatttatgtttaatgccttggtagaataacaagccatggttcaagtttactaaac/a/ RBM24/RNA binding motif protein 24 3519/17/rs385894/537828/[c/t]/ttgaatttaaattttgtctctgctgttatctgtgtgaccttggacaagat atttaacttt[t/c]catctgtgacatggagataataatacgtacctcagggttaggggggattagaattaatat/t/VP S53/vacuolar protein sorting 53 homolog (S. cerevisiae) 3520/8/rs13258861/14523775/[t/c]/gcagagccaaatcatatagacttctgtctatagactaagtggagtct ctcctctgtcata[c/t]acttatatctatagaataagtaggatctctccccaaaccatacagacttatggtttggct/c /SGCZ/sarcoglycan zeta 10 3521/2/rs10207672/234552900/[c/t]/cactctggaattacccaaatccagtttatggattgatttaggagtc atccagatgtggtc[t/c]tctcctttccctcttcgggaaaatgcgaaaagagaaaggatactctctgtttatttcagt/ t/TRPM8/"transient receptor potential cation channel, subfamily M, member 8" 3522/1/rs6604568/216160774/[a/g]/cctcagacttccagcctccagaggtgtgagatgataaatttctgttg cttaaatgactcc[g/a]tttgttgtactttgttaagtcagtcctaagattctacaaatgcccacattttccccattc/g /-/3523/3/rs9824372/104782878/[g/a]/tacaagaaagaccttttttcacaccacctgagagctataacctgagc cattggtggcctg[a/g]gtattctaactctggaagtcaaaaaccagagtttaatgtaggtggccactcaggaagctg/g /LOC644681/similar to synovial sarcoma 3524/1/rs966209/216174711/[g/a]/gccctcccctagccttggatccattgattactgagagttggccatgag 20 tttgaaatcggg[a/g]atacaatgataagtaagataaaactcaaccactttatcttaatcgtctttttacctgtgt/a/ -/3525/2/rs1729659/61157775/[g/a]/cgacgttcacattttcaactggttgataaaatacattaaaaggaacac taaggagaataa[a/g]gattgtgagatgcccactttaggtaaaaaacaatctgttgcttaatttgtagtgaaattt/a/ KIAA1841/KIAA1841 3526/11/rs643122/112192679/[c/t]/tatggaggaaaagccaggcagatgttgtaacaaccaaatgccccaaa agccaaaactgaa[c/t]ggtcaggttcctagatcaatagaacctgcttcattgccttactcattccttcacttacca/t /-/3527/16/rs7206177/86714792/[c/t]/cagcagcgccaaacccttgccaaaggggtcgtcccccccagtagatg tagggatgggttg[c/t]gtattataattttattttttatttttctagttttttcattttctagtgactaatgatttt/c 30 /-/3528/2/rs11123905/102037499/[a/g]/tcttctttttgttcactttaaattttaaattagtcaattctgtaat gttagtaactgacc[g/a]tctgctcacacggaagtcatttatttgctactttcaaccattcagaatggagttaagaat/ a/-/3529/6/rs3860243/97012024/[a/c]/ttttccctcctctatcaacctgctataaggaactttagatattgatga ggtaaaggcgtc[c/a]aggcaatcagggtatgtcccatggagtctgattcactagcttatgtgatttactttgact/a/ -/3530/4/rs11722430/148245164/[g/a]/tggttaataatagcatagaaaatcacaaatttattcacactataaa tatgtgtaaagaaa[g/a]tacagatttccacttcctccttataattgagtctatctttctcataagcctctacctgat/ g/-/- 40 3531/11/rs7104546/19035033/[t/c]/ccacccttaatgactgagaggagtccatcaacagtcagaatggagat tgtgatttagggt[c/t]ataacggagaggtgacttcttgctaggacaggtctgaggacagccaggcctgtcagacta/t /MRGPRX2/"MAS-related GPR, member X2" 3532/7/rs2893236/26004983/[c/t]/ggtgaccatgggcagcagttttctgttgttttcctcatctcagtggtg gcagcagtttct[c/t]agagtaagactgtatgggtgaacctaaaagctcacggtgcctcccgtgacttttgctcct/c/ -/3533/6/rs4840017/99786299/[t/c]/ttctttgaatatccctaggtgattctgaggtgtagcacccaagtttaa aaaccactgttc[c/t]acatagtatgtgcttaataagtagaacctattataaatttgacaagcgttcagatgactg/t/ -/3534/7/rs1589764/10362495/[a/g]/ggccctgaaatccaccagtaatacccaagaagcacactgtggaaactt 50 (256) JP 2010-88432 A 2010.4.22 gggttctgagac[g/a]tactggtttcaggagagactcagcacattcccacctagctatggtgaaagactgtttctg/a/ -/3535/9/rs872611/91363945/[g/t]/ccacctaagctgttatctctggcccctcccctgtccttgcggcaaatcc cacatgaagtg[g/t]acagcagatagtcaaaacattatttaattcacagcttctactactctgagtttagaatgg/t//3536/2/rs719645/50736804/[c/t]/tgagttacccgcattttctgggacttctgaaataacttccaaactattg ttcctcagact[t/c]accccacctctcatacaccacttcaccccctgcccccaaacacacaaaagcaaagtgatc/t/N RXN1/neurexin 1 3537/2/rs10497942/211662164/[t/c]/cagaatattgccttcgtatcattggagaaaaatttaaagtgcatat tactctgaaaagaa[c/t]tggtaatatcgagatacacaagagtgtaactctagtgggtaataaaattattccaaatcc/ 10 c/-/3538/11/rs646809/94474519/[g/a]/tgaggggcttattagatgtggcctcatagagttcaaagaaatgctgaa ccttgggaacta[a/g]aataaaagttatgaaatagtccgtgtgtctctaggtgttatggaaatttctagaatgtta/a/ ENDOD1/endonuclease domain containing 1 3539/14/rs4143873/32689273/[g/a]/tgagtctttaggttcattctgacatgtgacatcacagagccaaaata actttgatgaagg[g/a]tgagtgctgaaagacagttaatctcttaaacctcagcaggtgctcacttaattcagtaat/g /NPAS3/neuronal PAS domain protein 3 3540/6/rs1338167/102008690/[a/c]/tgaattcacaccctttgaagaagggggacaattgagttattcctacc gtagactgaagga[a/c]gaaggccgattttcctgttgcctcctctctttcctgttttctttttcttcctccttagtt/a /GRIK2/"glutamate receptor, ionotropic, kainate 2" 20 3541/18/rs1602895/26838554/[g/t]/ttatcttatatgtgttgtcccttgtaattccttagaagggagcccta aagaaataatttg[g/t]cattggagtagcccagtagtattccagtaatgtttatctatacaaactaatactgttagg/g /DSC3/desmocollin 3 3542/11/rs608426/99083719/[t/g]/tatattagatattataatagagcatatttcaggtatgattgctgagag attatatgggaa[t/g]gctaaacattttaacaaggagaataaatgttttctggtatctctcatataagcatatttc/t/ CNTN5/contactin 5 3543/1/rs10927653/15241140/[g/a]/cgttctgtgacagttgctgctgagcccagctctcctgctgccgcgga atatgaccccaag[a/g]aggtgggagtccaaaacttgaaagcacctacaggccttcccacccggcctagagcccttg/a /RP1-21O18.1/kazrin 3544/16/rs4788683/71555248/[t/g]/aggggtgcagttatgacgaaggggagggggctcctgctgttgctcca 30 gctcccggagaat[g/t]aaacatgaacagtcgcactgtgtaattttaaattgttaattagcacagggttaattaggc/g /ZFHX3/zinc finger homeobox 3/ 3545/11/rs2043055/111536834/[g/a]/catgtgttgattttgaattcttcattcttattttcttacaattctt cttgttagttctca[a/g]tacatctatgactgattacaagtagtgtgttctcatccccattcctcctctcctcaattt/ g/IL18/interleukin 18 (interferon-gamma-inducing factor)/ 3546/7/rs7806217/27904302/[t/c]/agtgtcttgaggacacaccacacacccatggctctgaaagcactgagc acacacgtgcct[c/t]gtgtagagcagaaattccgtttgtggaatggctgaatggaataaacccagagggtgcata/c/ JAZF1/JAZF zinc finger 1/ 3547/6/rs728589/143213706/[t/c]/taacatttttcagttgggtttcttgcttactattttcaaagtgactgt tttcttgtcctg[c/t]gacagtgttcagggtgagaaccacggtgaggtatgaccccagatggagcaggatgaatta/t/ 40 HIVEP2/human immunodeficiency virus type I enhancer binding protein 2/ 3548/20/rs1054185/48802413/[a/g]/tcacctgtgacaggtagagtttatcactattaattttatgaggctat ttattactttcca[a/g]tgcatccacttagaacaagctaagagtaaggctgctaactttaattccttgcctgatttt/a /PARD6B/par-6 partitioning defective 6 homolog beta (C. elegans)/ 3549/2/rs1518551/50735657/[g/a]/agaggaaagaggagaacaaagcaaggaacaaaagaataaaaaaggtct aattaatttgca[a/g]cctggagaaaacatgtcagatcttgatgtaaaatagaaaagtctggaaaattgggatttt/a/ NRXN1/neurexin 1/ 3550/19/rs8110509/35673479/[a/c]/actctctcctaagtatgtcctagggcaccccaagatgatgatgttgt ttgctagggtcca[c/a]taccaggaaatgtcaagtattcgggattgcccacgaaagagtttattttggtataagaaa/c /ZNF536/zinc finger protein 536/ 50 (257) JP 2010-88432 A 2010.4.22 3551/4/rs12510260/154090790/[c/t]/ccactgggatcccatgtgcagattccactgctctgaatgattccaa aacaccacccaacc[c/t]gacccgactttgtttctgaatggcccagctttgagagagcaagcatttgggaagtgagat/ t/FHDC1/FH2 domain containing 1/ 3552/9/rs7045999/121016745/[t/c]/ataaaaaaaaaaaaaagacacaatccttgcccttggggagtttacaa tataatcagcagg[t/c]gtagacatggacgcacatcatcataacatggctttatagacctatagcagagagagccat/t /DBC1/deleted in bladder cancer 1/ 3553/5/rs11957688/22871649/[c/t]/tttatttctcactcatccaaagtcaactgtgaatctgggcaaatctc cagaaagctgtcc[c/t]caatgtgatggctcatcagttccaaaatcatctcctgtttccatacttggcatggccctg/t /CDH12/"cadherin 12, type 2 (N-cadherin 2)"/ 3554/3/rs9826842/187362894/[t/c]/ctcaaacagtcagctagaaggcccagagtacgtgccaaaaactccac 10 tctgaaaggggaa[t/c]tggcctggtctctatgttgagtgagaggttgcatcatgtcaatgaggtaatgtctccaat/c /DGKG/"diacylglycerol kinase, gamma 90kDa"/ 3555/7/rs1979768/83044509/[t/g]/tatgacagattagagataaacagatagatagatagacagatcgaccaa ttgatctatact[g/t]ctccttttgtccaaggagaccaaaaatttggacagttttgaaaagcgtatgttgcatgtt/t/ SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E"/ 3556/4/rs168282/79473082/[c/t]/cagaaaacagttctccctcccttgggacagctctctatcactagatact ctgctgcttat[c/t]gggttgctcaaatcaaagggaaaagctggtgagagcttcacttattgatttcacataggt/t/F RAS1/Fraser syndrome 1/ 3557/21/rs222956/26841803/[g/a]/gaaaattatctgacaaaagtcacattaatagatggcatataaaattat 20 taatgcgcatgg[a/g]agagaatcatagagtggttgccccaccacacattggggtacagatggttatataccctta/a/ CYYR1/cysteine/tyrosine-rich 1 3558/15/rs2028122/58628567/[a/g]/tggtcttgtggaagaaaacaggaaaaatctctggcattctcgatatg ttctatgatatgt[a/g]gcagctcttatgttctgtgtctgtcgcctattttgtaaacaggcaacaaaacaccatact/g /RORA/RAR-related orphan receptor A/ 3559/4/rs7674131/5684896/[c/t]/catgtgtgcacaggcacatacacaatgtgtaaggcaatgtacacacatg caatatgtaca[c/t]gcacacatgggcacacacagaacttgcacacacacaaggcacaagtacatgtgcgcacac/c/E VC2/Ellis van Creveld syndrome 2 (limbin)/ 3560/1/rs946448/54433738/[a/g]/agtgctgcggcagtggctgctcaccctgtgtgtttgacctctatcaccg agatctggcaa[a/g]gtgggaggcagcccaagccagcaaggacaggagcctgctgcgtgggccagagtcacaggt/a/L 30 OC606495/hypothetical protein LOC606495// 3561/2/rs1531133/46697135/[g/a]/taatacagtgagcaggacccaaactcaaatgtttgctgaatgaatgaa ggaaccagagta[a/g]gcaaagagggaaccagcaccggttaggccctggcgtgcccccaggacgcctgcagaagtg/a/ PIGF/"phosphatidylinositol glycan anchor biosynthesis, class F"// 3562/20/rs6012521/46766551/[c/t]/agaacaaagggctcagaggaagaggaggtggtaaggagagaggagga tgagctgcagagg[t/c]ctactgcttccacctgctcctctctcgggccatggagtccaggagaggtcaccccagcca/t /PREX1/phosphatidylinositol 3// 3563/20/rs4810865/46761765/[g/a]/ttcttagctgagcatgagggcacctggaataaaggccacacgcccag tctgcctggacac[a/g]aggttctcatggatggggcgcgagcagaagtgccgggtgcagtttcccttctcctttccc/a /PREX1/phosphatidylinositol 3// 40 3564/9/rs12378647/121041535/[g/a]/aaaatgacccaatcctgtggatgtgcatttccaaaacattgtctta gaaagacttgaggt[g/a]gtgggtaagagaggaacagctattcaaaaagataaccttgaaataagaatggcttagtat/ g/DBC1/deleted in bladder cancer 1// 3565/18/rs4799703/29445545/[c/t]/tcaaagttattggaaggcttttcagatgattggaatcatataatcaa atggccatgctgc[t/c]tctatagacgggattaaaatgtgaatattccagtctgctgcttttgtggatggatatttg/t /ASXL3/additional sex combs like 3 (Drosophila)// 3566/10/rs10887758/89593295/[c/t]/aggtcatttagtagtagtatgcaatcaataaatattcattattact tgtgtgacagtgct[c/t]accccacactgtcctttatagaaacatatttgcagagacctggggagaaaatgcaaacat/ c/CFLP1/cofilin pseudogene 1// 3567/8/rs6982585/18740036/[t/c]/aatttctaaaacaatattctgccaatgacagtagcgcttcagttctga 50 (258) JP 2010-88432 A 2010.4.22 tttcatgtagag[c/t]gatggctttatgtgatcaagaaacattaagtacgaaaaattacctaaaggtcagcaatgc/c/ PSD3/pleckstrin and Sec7 domain containing 3// 3568/6/rs1856310/102004252/[t/g]/attggacaaagagagtatgatctaatgataataaactggtggaattt agcaaattctgtt[g/t]attcagattctcctttgtgtctctgtgtctccagagtattctgcatagtattctttgaca/t /GRIK2/"glutamate receptor, ionotropic, kainate 2"// 3569/1/rs2744690/14010388/[t/g]/atgcttcctgtgggttatggtgatggcatggtcactgtgcaagtaagc gttaacgagcca[g/t]tgcctcacttatccagaggccccttaaccttcacaatccagagaacagcctagaacgttg/g/ PRDM2/PR domain containing 2// 3570/2/rs1869836/46735897/[a/g]/gggatctgtgggctccacagtcgtcccaggcctccttgcttaatcgga ctcccacccatg[a/g]catctgagtagttcctcttctggtcctgtcactatcatctccctttctctctctcaaggc/g/ 10 LOC730078/hypothetical protein LOC730078// 3571/3/rs17056288/55968991/[t/c]/agctggtggcagatgcacttccaggagggttcaaagcagggttcctc tgccatctgtgcc[c/t]gcatgaaaatatcccctgcttcagtatgttgtggctccacatatccacctggtgcctcaa/c /ERC2/ELKS/RAB6-interacting/CAST family member 2 3572/13/rs1305088/28176450/[a/g]/agctttgccctgtggacactggaactcagctatttggagtttccaac atctctcacatca[a/g]gtccaaggagaacctttcccttagtttcctcagctgcagaatgggctgctgacttctcag/g /SLC46A3/"solute carrier family 46, member 3"// 3573/8/rs4871345/124165408/[c/t]/ttcttcatcaaagcctttgtcagccttgtctcctacatgaatgagat gttgctaacatgt[t/c]ccgtcatacactttatcaactagccacaagcttccatttttgtggatattaatggaggtg/t /WDR67/WD repeat domain 67// 20 3574/1/rs2977313/17442536/[c/t]/agatccaagtccaaatgtcagtctcatcattctctggctgtatgatta tgtgacttaacc[c/t]gtctgagccacagcttcagagggaggctgtggcatttagtgatgatatatctggcacata/t/ PADI1/"peptidyl arginine deiminase, type I"// 3575/4/rs366463/79481720/[t/c]/agaccatttttgcagacaaaacagcaatctgagatgagccaacctaaca tactattaata[t/c]ctggtgaaatcgtgaccccttctctttatcccctcagcaacgttctcattagaggatttc/c/F RAS1/Fraser syndrome 1// 3576/4/rs1454890/79485587/[a/g]/aagaactgttgggtagaattaaggacttgaatcagctgtcctcatatc taatcctcttct[a/g]atgcctcatatgataattatgacaaggatctttcttcttagtgtgagtcatattttggtt/g/ FRAS1/Fraser syndrome 1/ 3577/4/rs1454891/79485671/[t/c]/aaggatctttcttcttagtgtgagtcatattttggttcttatctcctc 30 tttttcaacttc[c/t]tctttattccttctagtcctgttcttctatctctgtatttttttcaatttgctcgtgtct/c/ FRAS1/Fraser syndrome 1/ 3578/4/rs11942379/7623618/[t/c]/gctttgctgttctgccccttttccagcccatggcagcccagggagact tcagaggcgcag[c/t]cactctccaaggaaatccctgcctgtggctttagtgagaaccccatcacactgtccccat/c/ SORCS2/sortilin-related VPS10 domain containing receptor 2/ 3579/6/rs1865448/143620055/[a/g]/ctgcctccgtccatgcccgatggctttcatggagcactccaagatcc tgtggtctcatcc[a/g]ttcctggagtcaagaacacctgaatcactaaaataaaatgaggtttgaaatgtggtgttt/g /AIG1/androgen-induced 1/ 3580/18/rs685658/347570/[g/a]/catttgtaaaaattattcttagtcccaatatttgaacctaaatgcaaaaa gataaatttt[g/a]aaatgacatctttgcttactgttattaaaatttgacttctcttacaggtattcaggaagg/a/CO 40 LEC12/collectin sub-family member 12/ 3581/2/rs1729657/61157506/[g/a]/gtgttcagaattttcaaaaacatcttgttctcttcccttcactaaatg tcagtattcttg[a/g]ctccttttctaaaactctaataatttcatttttgtgtaacatttttatgaaggccaaaca/a/ KIAA1841/KIAA1841/ 3582/2/rs1177298/61160258/[t/g]/cacataaatatgatgaatcgaataattttttttctctctctacatgtt ttgatttttatt[g/t]cacacatacatattatagctggttagtctggaatctctggattctggctgaaatttttga/g/ KIAA1841/KIAA1841/ 3583/3/rs9877840/174924370/[a/g]/cccaggagatttatttgattaatgatgattcagatagatggtagtgg tttggctcagaac[a/g]gtatcttaagaggtgtcatgaaatggtcagattctgatgtcttttgaagatagaaatgac/g /NLGN1/neuroligin 1/ 50 (259) JP 2010-88432 A 2010.4.22 3584/5/rs9285864/108489491/[g/t]/gttgttcctaatatcctttttcctaaactggaaattctttttaggca tcacctgactgtt[g/t]cgggactctttgttcttctcctttgtcagaaagaatgaaacggtgaaggctaaaactgct/t /FER/fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) 3585/1/rs2791390/244024451/[c/t]/gccagcgatgttctgaagattcactagtgtgtgtgtatttacatttc tttgtattgatac[c/t]actcagtacttgggggtatgctttgaatttgagggttcatgccttttaaaaactctgtca/t /SMYD3/SET and MYND domain containing 3/ 3586/10/rs385209/119294046/[g/a]/aatggacaagccgcggagtattgatcggctgccgccggaggtaggtc ttttactgactcc[g/a]atccgtaaactaattactcctttttctgaagttttaactctcctcctcccaccccgtacc/g /EMX2/empty spiracles homeobox 2/ 3587/3/rs10804682/143717224/[a/g]/tgcttacctttttccagtatccttcttaggggtgaagtaggtcatt 10 cttggacacctaaa[a/g]tacttctaaggatttgagtctgccccctcctcttcctcagatccttccaactctattctt/ a/ATR/ataxia telangiectasia and Rad3 related/ 3588/6/rs6932052/2814030/[g/a]/caatgggaggataactcttgatacttgttactccacctcggctggaatt agaagtaacaa[g/a]ttaggctctcagctttgttaccacccgtgacatgaggggttgggctaggtaagtgcatgc/a/M GC39372/hypothetical protein MGC39372/ 3589/3/rs1056664/198231026/[c/t]/ttgcccagcactagagcgcatcgtcctacgtgcttcctcgtgtgcag ggcactcgccttc[t/c]tcctcctcagatctggtccatgtttgccttcgtgatggactttctgatttaaaaggcaat/c /MFI2/antigen p97 (melanoma associated) identified by monoclonal antibodies 133. 2 and 96.5/ 3590/4/rs6855967/147987656/[a/g]/tgtgtgaacatgttcctttaaaataaaacatggtaggaaagtcttcc 20 actgaatgctttc[g/a]cacagaagaagcttcgtctattaccctttcacagtgatagaagagacaagataacaattt/g /TTC29/tetratricopeptide repeat domain 29/ 3591/10/rs1676741/127841520/[a/g]/tctggtaggaggtgtttggattgtgggggcggatccttgatggctt ggtgctgtcttcgt[a/g]agaatgagtttttgcaagatctggtcaattaaaagcatgtggcacctcctcctcccaccc/ a/ADAM12/ADAM metallopeptidase domain 12 (meltrin alpha)/ 3592/3/rs9853928/104778074/[t/c]/tagtaactttaccccagttatgcagcagtaaatttgggcaactggaa tttaaaaagcgtg[c/t]atctgattctgcagttcataatatcttcatcaggtcaaacagagaaagaataatctactg/t /LOC644681/similar to synovial sarcoma 3593/13/rs462954/91169091/[c/t]/gttaacttcagtacaatagaaacaccatctcaatggggtacaaagtat gtgccaaagaaa[c/t]gctataagccatgagtggtataggagccagagaaaatcactgggaaccagggtcttcagg/c/ 30 GPC5/glypican 5 3594/11/rs2509814/94469162/[c/a]/tgagtcagtttctttttcatttctccttcctttcagtggccaaatag atatatcgacagg[a/c]aatgaattattactatgacagatgttaagtttcatgaaaatgaaagggtaagtcaccatt/a /ENDOD1/endonuclease domain containing 1 3595/14/rs226981/44732075/[g/a]/ctgatctgtggtcttcacctaagctctgaaggcaatagagtttgctgc tcttcccacagt[g/a]gcttaaagctttttgttccataggggaaacagggaaggaacaaggtgaggcatggttcct/g/ FANCM/"Fanconi anemia, complementation group M" 3596/19/rs2915942/43697777/[t/g]/ggttccccacggcggccgcgtgagggcgctcagggacaggtcagcca cggaggtagagcc[g/t]ccaggtctggggctgtgaagcaggcaggcctcgctggggaagaaagggaggcgcagacca/g /RYR1/ryanodine receptor 1 (skeletal) 40 3597/5/rs10513162/13967120/[t/c]/tggtattccttaaaatcaaaagaaaaatatacaacaaagggaacaag aaaggtatcaact[t/c]tattttcttaagtgaaggcgacagcaaaattaggatggaattgtaagccttttcatagtt/c /DNAH5/"dynein, axonemal, heavy chain 5" 3598/5/rs7713700/13971291/[t/c]/cttccagaattaatttacataaagactgtggcttctaggttggggact ctcttgccctcc[t/c]tcacttgctccctttaagggaagccagctgctatgttctaagctgctctacagagaggcc/c/ DNAH5/"dynein, axonemal, heavy chain 5" 3599/22/rs41158/28735983/[a/g]/tgcgttctttatttgatttattaaatcagatgctgcctaaaccacttat attgactgcca[g/a]tagcaaatgattaaattcaccgtagttgtcatcagccaagaggatgaagcagtgcctttg/g/M TMR3/myotubularin related protein 3 3600/9/rs2073815/135563233/[t/c]/cgtcgtcttcccccacgatgagccgctggccgggcgcaacatgagga 50 (260) JP 2010-88432 A 2010.4.22 gagacccgctgca[c/t]gaggtaacgcccctacagctcctgctggggactggcagcgagggtctgggacgtcctcag/c /SARDH/sarcosine dehydrogenase 3601/19/rs11881315/10770953/[t/c]/accccgtctcttaaaaaagaagcagcaaaggaaatccccaggccct ggccaccaccagcc[c/t]gctccctatcctacagtccttcaagtggactcccacaacgtaaggcccattgactcttga/ c/DNM2/dynamin 2 3602/2/rs13002299/170927895/[t/c]/tgaatcacacggcagggaaatgcttgctcagatccaaaatgtttag atcttctgtagcaa[c/t]gggaacacataacaattcaagtagcaggcctgcaagaaaatagcaggaagtataaaagac/ c/MYO3B/myosin IIIB 3603/10/rs242965/119240201/[g/a]/ccaggaccctgggtggcactgccaggaagcaacagagaggagataaa actcacagcagac[a/g]gacttgccttaacaacaactcccttgaattaaaacacgcttttcaagaaaacaaattatc/a 10 /EMX2OS/empty spiracles homeobox 2 opposite strand 3604/1/rs606604/117001407/[c/a]/tgtgatctgacccacagcaaatgatggctgctcaactctgcatctcct ttcctctccctg[a/c]tgaaaagtgccacctagcaaggtcaatcaaggtcaccaatgcaaagaagtagtgggcaaa/a/ IGSF3/"immunoglobulin superfamily, member 3" 3605/3/rs10937103/184096377/[a/g]/acccttgttctggcaggatgtcttcgtggtgttccttggaccttta tccagcaagatacg[a/g]tagggctctttctttagtggtcaggtggttaggcaggatgtttctcatgtcccgaacccc/ a/ATP11B/"ATPase, class VI, type 11B" 3606/13/rs1337835/93419433/[t/g]/gatacacactgtggtcatcttcccagctatgttctacttctccccag tgttatggcagct[g/t]agtagtttaaaagggattgatatcaactgtggtttgatactgattgtactggttgtatca/t /GPC6/glypican 6 20 3607/1/rs12410676/107986832/[a/g]/acagactgtgtgcatctcctttcagaagttcaacggtatccccggc ctggagctgtaaag[g/a]gggtccttcatgcagagctgggggtggtgttccagaatagttcctaatgacctgcatctt/ g/VAV3/vav 3 guanine nucleotide exchange factor 3608/1/rs12121189/19613008/[a/g]/agttttgcttcactccacacagctgtccctggaaaaatgatttccag atttcattgcttt[a/g]actattaaagactgaaaactgagcagcactgcttagcagacatcagatattctgctaatc/a /CAPZB/"capping protein (actin filament) muscle Z-line, beta"/ 3609/18/rs12607553/26841557/[g/a]/cggatattctgattcagttagtctaacaaagtatctacagattaat atttttattttaat[a/g]tgaagacaaggttgaaaaactctaggttactttaaggaacagaattcaagaaaaggatca/ g/DSC3/desmocollin 3/ 3610/7/rs6962089/146431039/[a/g]/cagtcttttcatctgactattgaaacctcaagtatatttgtagttgt 30 agcaccaagatgg[a/g]tcagcgagattcttgaaatttcttccaatctagtgactctaattttttaatgaagtatga/g /CNTNAP2/contactin associated protein-like 2/ 3611/19/rs10412203/53207935/[g/t]/aaaaattcattttgggagattggttaacatcagtattataatataa aaaagcactaccac[t/g]ttccataaataggaagtacgaccaaaaagaaatactgtactatgaaaacaaaatcccatt/ t/ELSPBP1/epididymal sperm binding protein 1/ 3612/16/rs1529496/75939382/[c/t]/aatagcacatcccccaaagatatggaagtattaatatgtatcgtgtg cttaaagtactat[c/t]tgatacataataagcactgaataaatattagttattattataggatggaaagagtatctt/t /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 3613/16/rs9930984/75911474/[g/t]/ggtaactggaggaaacctgcagctcctggatttcgatgcttcgggcg ccagctggaatga[g/t]gaccaccggataatattctaaatggaaagaagagaacatgtctgaattccaccccatgca/t 40 /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 3614/3/rs13073932/66557177/[g/a]/gacatatttcagtgcaaacaagcagctctggctcccctctcaggaac gaagggctgactc[a/g]gagctctcactcttaacttcaagcataaaagaagcctgctccagctggagagtgtcaaac/a /LRIG1/leucine-rich repeats and immunoglobulin-like domains 1/ 3615/18/rs11081675/26834675/[g/a]/aatagcccctaaactttatcatctcctgtcttgtaggctatgctgt tttcctcttcttta[a/g]ctattctcaccgtctcttcactttcaaacccttcttattctttaagttaccaagtaagct/ g/DSC3/desmocollin 3/ 3616/2/rs2110745/40354855/[a/g]/tggggctacaaatatgataagatgctgtacccaggtttccttggtaga aatctagtatgc[a/g]aatgtgatcatggagaacaaacagctagaaagcaacagtgcccagtctattccatccaca/g/ SLC8A1/solute carrier family 8 (sodium/calcium exchanger) 50 (261) JP 2010-88432 A 2010.4.22 3617/9/rs4745380/76935819/[c/t]/tgttcattaaatgcttatcatggcagtttggagactttgagagatgag agacacggctcc[c/t]gccatgaagctgcttcaagctggaagtgggacaaacagataaaacacttgtttagttgtc/t/ OSTF1/osteoclast stimulating factor 1/ 3618/22/rs7287478/28452657/[t/c]/cctctctcacatgaggagattgattctgcctgctgaaagctaaaagt ccacccaggggaa[c/t]agcttaggcaaaggccaggtggctggcaagcaaacaaggagacccccgggagccggagag/c /CABP7/calcium binding protein 7/ 3619/9/rs676472/4033590/[c/t]/atcatatcctaaagaaggagaaggtcagcaccatgagttttgtctcaatg actcagttat[c/t]ggagggctggggaggtggttttgagcacactattctactgctgagtttgctcccaggaaa/t/GL IS3/GLIS family zinc finger 3/ 3620/7/rs17275986/80256625/[g/a]/gagaaacaggacatggtatctcccatcagcagcgttcactcgatcca 10 cagctatctttgt[g/a]tacttgtagtcagtgccaatacgaacaatcaaaggccttttgtggattgggtagatggaa/g /SEMA3C/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C"/ 3621/8/rs1036821/135719665/[a/g]/agtcaaattgtcctggcaagaaaaagaaaaaataattacaatctaaa gccacaaattata[a/g]cactaaagacaataacaatatttttccagtttcctagcgacctagtgattttcaatggca/a /ZFAT1/ZFAT zinc finger 1/ 3622/11/rs6485451/43699878/[c/t]/tgtttgaggaaaggcaaagccgagagtataagaggagaaaatggtag tagaagaggggca[t/c]gaacgaggtcatgaaatatcctgtaggacataaaaaaacttgagctcttattctgagtaa/c /HSD17B12/hydroxysteroid (17-beta) dehydrogenase 12/ 3623/16/rs7187583/87700761/[a/g]/ctgcggtggtgctgaacgatctcagacgcggtgtcttcaagtcatcc 20 tgcacagagggcc[g/a]tgggtgtcagtgcctgcaggtgacggatggggttgggggagaggaggaggatgccggaag/a /ACSF3/acyl-CoA synthetase family member 3/ 3624/8/rs16914760/51432067/[c/t]/tgctgcttctcaaaaatccaacaacctcagcgtgacttttgggcctc aatgagctggaca[t/c]gggttctgtttttccagtcttagggaatgcgtaactggaagggcttcacacttgtgttat/t /SNTG1/"syntrophin, gamma 1"/ 3625/19/rs33429/35631200/[c/t]/tttcttaatagaagccttaataagtacttctttctttacttaagggctt aaagatttttt[t/c]tctctctctccttcaccttgcaggtttctctttaacaggtaataataaaatacccattgt/t/Z NF536/zinc finger protein 536/ 3626/1/rs1048971/205712945/[a/g]/caccatccgttgtacaagcaatgatcaagaaagaggcacctggagtg gccctgctcccct[a/g]tgtaaactttccctccttgctgtccagtgctcacatgtccatattgcaaatggatacaag/g 30 /CR2/complement component (3d/Epstein Barr virus) receptor 2 3627/7/rs225137/136597446/[c/t]/caaagatctcattactgtctgaaaatatttaaccaaaatgaaaaacac ctagttattttt[c/t]aggaaaattgttgtactttaaagaaaaaaatcccttgggcatctcaggtaaaataatact/t/ PTN/"pleiotrophin (heparin binding growth factor 8, neurite growth-promoting fac tor 1)"/ 3628/11/rs4910584/3865098/[t/c]/agcaggatacattcttgtccttatacttccttccctgtttctgtacct gctcacttttgc[c/t]ctgcaacaaataaacctttaagcatctgttctcagcctggccttgcactgggcaaaactg/c/ STIM1/stromal interaction molecule 1/ 3629/9/rs7038764/113254157/[g/a]/attagggttacctagttagaaaaatagccaagtttccccaagaaagc cactatgagagac[a/g]tatgttaagtgacaccatggggatactctcagcaaaacccagactgtgataaactttaga/a 40 /KIAA0368/KIAA0368/ 3630/17/rs7213791/2197809/[a/g]/gctccaggtatgctcctgccttggcatcccaagtaactgggattacag gtgcataccacc[g/a]cccgaggtccatagtgttttatttaccctattccgattgggcactgagtttgcattttaa/a/ SGSM2/small G protein signaling modulator 2/ 3631/15/rs1551343/66872811/[g/a]/agtgtcgcaggtgtgccccatgtggagagggctggagacctgcatgc agagcactgggtc[a/g]ttcaggtcagggggagtgtgcacagctgacctgcctctcaggggcttatgcttgtcttgg/a /ANP32A/"acidic (leucine-rich) nuclear phosphoprotein 32 family, member A"/ 3632/20/rs6013590/36047192/[a/g]/tgcatactgctgggcattaaataggaacttcaacgcctgctaagtcg gagtaaattctgg[a/g]ttttaatttcactaatatgaaagacctgcaccctcaggggatttgggtcttaccgtgaag/g /KIAA0406/KIAA0406/ 50 (262) JP 2010-88432 A 2010.4.22 3633/9/rs1260463/6622061/[g/a]/gaggttgcagtgagccatgatcatgccactgcagtccaacctgagtgac agtgagaccct[a/g]cctcaaaaaaaagtcatatggagaaatttgcagtccaaccgagaatcacaccaagtaaat/g/G LDC/glycine dehydrogenase (decarboxylating)/ 3634/15/rs1490079/27091095/[g/a]/ttgtccaccatatgattaattttgacagactatcccatgtgcccttg tgtgtagttcctc[a/g]gttcagtactttcgatatattcatgaggaaaaatgggtaattgtggtgttcaaatcttat/g /APBA2/"amyloid beta (A4) precursor protein-binding, family A, member 2"/ 3635/4/rs1110956/154085380/[g/a]/ttgaagtgtaaactatggcataaatttgagaaggaaatcttcatgag aacccttagtgcc[a/g]tcagtgctgaacacaggcttgcctgtctcttccttttatgcaaagtccttttatttgctg/a /FHDC1/FH2 domain containing 1/ 3636/12/rs4930793/5688895/[t/c]/tccccttcaatgatctcccttctcctcagtgtattttttcccaaaata 10 tttctagctcaa[c/t]tccttctaagtacttaaacctcatctctactacaatcagaaagaaatcaaatcctggact/c/ TMEM16B/transmembrane protein 16B/ 3637/6/rs2277125/43748077/[g/a]/tcatttggctcactcagctaccccaaccttcagggaactccccagggt actataactggt[g/a]taagacccctgcccctcacccaacctgtgatgggaatcaaggggtaagggcccgtgggcg/g/ MRPS18A/mitochondrial ribosomal protein S18A/ 3638/3/rs9855051/155623224/[a/g]/cattcattgttgtttgagccagaacacaaacaagaacaagtttgatt caaagaaaaaata[g/a]aagtagaaacagatgttcatattttatatactgtctcatttatatttttactgacctttt/a /GPR149/G protein-coupled receptor 149/ 3639/8/rs10100417/27741404/[t/c]/ggaagctaggagaaaagcagaggcagagctacaggcaaagttacaaa agggtctagggac[c/t]ggaatacagccatcagccaggatcaggagcagacaaccgaatctaaatactggaattttc/t 20 /PBK/PDZ binding kinase/ 3640/2/rs6715297/180105114/[c/t]/ttaatggttcagcttgacattcaacatttgtccatttgatttataat tattctcacgtga[c/t]tgcaaggaggctatggttcaaaccaaaagtagtttaaattgaactgtcttttcttctgaa/t /ZNF385B/zinc finger protein 385B/ 3641/9/rs10867429/81631471/[t/c]/ttataccagtgaatgcacttgaggtgcaactgcttgatctcacagca atgaaaggataac[c/t]gcctaaaagtataatttctggtttaaagaatgtatgcatatatttttagtttgataaata/t /LOC347119/hypothetical LOC347119/ 3642/19/rs2043332/10752239/[t/g]/agttgtgagtcattagtacgccaggaaaaagggtccagtgggagggc ttctgaagcctga[g/t]gtcacaaaacgggagcaggcctacaagtgagctgagagtggaagcgccttcgttcttaga/g /DNM2/dynamin 2/ 30 3643/3/rs2872337/155590348/[a/c]/accagaaactgtggtttgaaatagtaagttaacacatgccacagccc cactcccttgctc[a/c]atgcaaagtgtttgggtaggaaaaatccttagctccagattttctcttgtgagggaagaa/a /GPR149/G protein-coupled receptor 149/ 3644/8/rs11785137/124176563/[a/c]/tcttgtcttcatgtggtattgtttaatatgatcctctgttacctgt atttttcctgtata[c/a]tggttatacctgtattttctaaaaactggaggcttgatctgatttaaggacaagaagaca/ c/WDR67/WD repeat domain 67/ 3645/8/rs952656/124196776/[a/g]/ctatccttaggagaatatgttcttgtatttaggttgatttctagccct tccaaaaatgag[g/a]atttccttacattctctggaattccatgtcctaggctcagtaatgaagctaatccctccc/g/ WDR67/WD repeat domain 67/ 3646/8/rs4732748/27689983/[t/c]/tcaaaacaactgaaataaatagactgccatcagcaaatcaaggctcac 40 catttaaatctg[c/t]gctctccactgtatctttttacaaccaaaataagtggtacctcaatccactggagagaaa/t/ ESCO2/establishment of cohesion 1 homolog 2 (S. cerevisiae)/ 3647/8/rs2218609/94224423/[t/c]/acccagcttattacattaactaaagtatttctcattcatttgggtcca tagtttatccac[c/t]gaatataataatgcagcatttacaattgcattttgttgttgttgtgaatagaacaccc/c/LO C389676/hypothetical LOC389676/ 3648/4/rs10032759/5367345/[a/g]/caagactccgtcttaaacaaaaactcaaaatggatcatggattggagt gtaaagtgtaaa[g/a]ctataaaacttttgagaaaaaacatcataggagaaaatagatagaaccagtcacatagcc/g/ STK32B/serine/threonine kinase 32B 3649/4/rs10009157/5344204/[a/g]/gccttactaaattcatgtattagttctaataggtttctttgcagatta aaagaattacac[g/a]caaatcaagtaatttttcatcagagatagttttacttgctttctaatctagatggctttt/g/ 50 (263) JP 2010-88432 A 2010.4.22 STK32B/serine/threonine kinase 32B 3650/6/rs9389250/99877918/[c/t]/taagtagaaagacacatgcttttgaaaattagaggatttggttaaatg tggggactgcaa[c/t]ctacacatggaagcaaagaaatcaaccaaaattaaaacataaattagtgaaccaacagtg/c/ C6orf168/chromosome 6 open reading frame 168/ 3651/16/rs10514569/82033605/[c/a]/aaaaaacttgcaatgtgaaagttttccaggtcaaagctggatctct ctcatccatcactg[a/c]gttctccaaggtgacatgcaattcaggagaaaagcatcagcatccagaaagatactggcc/ c/CDH13/cadherin 13/ 3652/1/rs3003423/17452009/[a/g]/tgtggctgctcatgtggctgaggggcccgcgaagctggtcacctttgg gattcatcacag[g/a]tgggcttggagagcagtccccaggctggttcagtgagacatctctggggtcttacacgcc/g/ PADI3/"peptidyl arginine deiminase, type III"/ 10 3653/1/rs2144549/115426871/[t/c]/gcttcttctcccatatgccttagtatttttaggcatctctttgtacc tgtttctggaatg[c/t]atcaagactaaatctgacactgaatataatctccctgatcacaggcttcagattttccaa/c /TSPAN2/tetraspanin 2/ 3654/5/rs976968/24604075/[t/g]/ttaagagtcttgttataaacaaaaaacataggatagaaaccagagagaa aatattaatat[t/g]ttggaaatacgacatccataaagaaatattgggcatggagaacatattcttaatttacat/g/C DH10/cadherin 10/ 3655/10/rs10762244/70265432/[g/a]/gcttcccaaagtgctgggataacaggcatgagccaccgtgcctggc ctgtttttaaacac[a/g]ttaagttacttaccttctcatcgtattatgcattgggccttttcgatatccttccgctta/ a/STOX1/storkhead box 1/ 3656/1/rs881247/19605907/[g/a]/cacacgatagtcatctcttaaaacccgggagaacagcagagtattttgc 20 gcaagtttgac[a/g]tgacctcagaactccatgcagacagctactacaagccaggtactatgctagaagctttac/g/C APZB/"capping protein (actin filament) muscle Z-line, beta"// 3657/3/rs2138244/191042451/[c/t]/ggcccaaactggttttccctgttccttcctcagctcttactttgttg tatcaagaagtca[c/t]gcttctacaaaaacgatagccctacctagagctcagcgtcctgcctgagatatgttttac/c /TP63/tumor protein p63// 3658/5/rs1030485/83412544/[t/c]/taaactatcctccatgttctgaatgctggttagcctttgacatgtgtt caattaacttaa[c/t]tgtcctctttgaataaccatgggaaaaga/t/EDIL3/EGF-like repeats and disc oidin I-like domains 3// 3659/4/rs1795722/90161886/[g/a]/ttcttttccaccataatctcagtttacgaccttaaaatagaagatagt ttccataaggca[g/a]gtcctctccatactctacttcttagctagctaaatcttcctaaaaccctgattatatttt/g/ 30 FAM13A1/"family with sequence similarity 13, member A1"// 3660/18/rs4797329/8771531/[a/g]/accatgtgacatttatatgttattctcctaacgtgcaaagaaggaaaa agactctttacc[a/g]gctcctttacccaatactaattgtgtttcagacaaataagaaaattaatttcagggagct/a/ KIAA0802/KIAA0802// 3661/22/rs6007903/45206869/[c/t]/tgaaagccagtggaggcgacactacgacctcaggcccagtggctgga ccccaactgctgg[t/c]gagtcgcagccaggcacagtggctgtgaaagaaggaagatgctctctccatagaaggact/c /CELSR1/"cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Droso phila)"// 3662/5/rs17275618/13940631/[g/a]/gatgctgcctccacttatcctgcttcatttcaacaactaacctccat gatgacacccaaa[a/g]gctgaaacccaccaaaagggcctttctttcaatcctgagtggtgtcctccttgaataatc/a 40 /DNAH5/"dynein, axonemal, heavy chain 5"// 3663/19/rs538852/7530079/[a/g]/gaagttcgaccagatctatgtgagtgggcaggagtggcatggtgcctgc ataggtggtcc[a/g]gctaagctttgctacttaaagcccagagtggtatgagggggaggaatccaggaggaatcc/a/P NPLA6/patatin-like phospholipase domain containing 6// 3664/11/rs1488540/102503586/[c/a]/gtgttggtggaaaaaggagcggttcagggaataagatcaagtggac accctgggctgagt[a/c]taaggcatttaaggaaacttaatttttgtgtctccagcacctcacaaaattcttggcaca/ a/DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1"// 3665/5/rs3765045/13964405/[a/c]/agtcgtgtgtttattttttcctttctgtataatgccgttaatcattac ccaatcagaagg[a/c]agaggtatcttcatcatggaggtgaccgatagcaacctcagcctgtgtttcgtgatttca/c/ DNAH5/"dynein, axonemal, heavy chain 5"// 50 (264) JP 2010-88432 A 2010.4.22 3666/2/rs6716352/144084727/[a/g]/attgtaattgttattaattagctacacatcaaagagcttgggttagc agtgggccatgat[g/a]gcctgaatcacaaagtgtgacttgttcagtgtatttatttatttatttatttatttattt/g /ARHGAP15/Rho GTPase activating protein 15// 3667/11/rs4601790/65110482/[g/a]/accaaggggcagctctgccaggctgctgcaaaccttcagctgtccag gaatgacccctgc[g/a]tttgaaggaaaggagtgaattcattgggaaagtctttctggaagaagccaccatttgagc/a /EHBP1L1/EH domain binding protein 1-like 1// 3668/9/rs491892/27183541/[g/a]/aggaatggaaccttacaaaagatcactccagtatttcaatggagggtac ctgggtaacag[g/a]aagctggaggtcaggttagcatcaaggaggcttcacagagttaattaacgcaatagaagg/a/T EK/TEK tyrosine kinase// 3669/3/rs1379717/56013039/[t/c]/aggctcttaaaaagtgtgtcttagcttaaagcaaagtaacagtttcta 10 caatatttcacc[c/t]tgtacaccttgacattgagccccagataaatagtgcaggtatttagaaaatataagttga/c/ ERC2/ELKS/RAB6-interacting/CAST family member 2 3670/3/rs10865916/42229487/[t/g]/ttactcatcaagactggttcatattgaggggagatatcctcaaaaac ttacacgaatcat[g/t]gcatcttgacatcttacctggcagtggccctgcagtagaaccatgtcctaattggagctg/t /TRAK1/"trafficking protein, kinesin binding 1"// 3671/17/rs10445209/63826422/[t/c]/gtgacagcacactgtaatcatgtttacttatgtacgttgatttgca atatgttaactttg[c/t]gccttgatctcatttcttctctgctttcccccttctctacccctggtttaattttgagtc/ c/ARSG/arylsulfatase G// 3672/3/rs2662126/4385432/[a/g]/agccctgcatgcacttgtacacttgcataaacataagagagcctaacgc acatatccctg[a/g]ctacctagcaggtattcagtgattaaccacagattacttcaaaagcctccacatgccaaa/a/S 20 UMF1/sulfatase modifying factor 1 3673/7/rs1859218/11532393/[a/c]/aagattcatctcctccagcttttcaaacacgaactgttcagtaacatg cccaactatttg[c/a]agcttcccaaatatcccaagttcttctatacttctgtgctttgcataatcatgcttttaa/a/ THSD7A/"thrombospondin, type I, domain containing 7A" 3674/2/rs1451156/46686106/[a/g]/agaaatgtttgttgaatggattaaaaaatgtcagggagcattttatat atcatactttca[a/g]tccttactgcaatttgtctcagtatttcttcctagtttaggtgacagaccaaggagcaca/g/ PIGF/"phosphatidylinositol glycan anchor biosynthesis, class F" 3675/20/rs6131989/17639406/[a/g]/tctcccaagctgtgtattatcatcttgtttcccctttagcttcgagc ctcgtcagtctgt[g/a]gctttcatcagatccagagagggtagaataactggccggcctaacggcggctgagccagg/a /BANF2/barrier to autointegration factor 2 30 3676/1/rs1108927/34105854/[c/a]/cggtgggaggtggccctccaccttcaagatgttggtaacaagagattg gtaacaaaggaa[a/c]ggaaattaaatggggaaggtagaggctggagatagaaacaagattaaagacagtctcttc/c/ CSMD2/CUB and Sushi multiple domains 2 3677/1/rs1857380/58176211/[g/a]/agggccctagctgccggcatgcctcttggccagcttgttcagtatcct tgggccctgtgc[a/g]tgatgttacctatagtcagggctaagctcttgttcagatgccctcatagtgaggccagct/g/ DAB1/disabled homolog 1 (Drosophila) 3678/6/rs1459047/21308369/[c/t]/tatttattttggattctaacttgaaaagactggcaagtcgctgcagtg ctaaaatagaag[c/t]gtaagggagacatcacacacacaagctacctgtgggtcccaaaggaagggaaacgtttgc/c/ CDKAL1/CDK5 regulatory subunit associated protein 1-like 1 3679/11/rs3794109/35148855/[c/t]/cagatgtctgtgtgtctctcctgagaaacagagaactctgtgattca 40 ggatccactttga[c/t]tcaagaagctaatactaaatggctgattgcatctctcaaacaagcctttctggctggaaa/t /CD44/CD44 molecule (Indian blood group) 3680/4/rs10519638/143444197/[t/c]/tggaaagaaaataaattacatcagaatttttaaaaaagccatctac cagaaatcaagagg[c/t]tacgataaatctataatctgtctggttcatagggagagaaaaccacaaatttggcaaagc/ c/INPP4B/"inositol polyphosphate-4-phosphatase, type II, 105kDa" 3681/7/rs10251377/146748387/[g/a]/aagtattatttggtgttctgaataccaaaaaagtacatcttgagta ccacaattggtgac[a/g]ttaaagttaattattttcattaaatattgcagtgctgtcatgaggaatgaaacagaagag/ a/CNTNAP2/contactin associated protein-like 2 3682/5/rs459770/178639683/[t/c]/gttagagtggccaagcaaagtcatcaggttctgtggagctcagaggca actctgttgtgg[c/t]cactgtgctcagcagaaccctggaaggcccagctccagccatagctccaagacagagccc/c/ 50 (265) JP 2010-88432 A 2010.4.22 ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2" 3683/10/rs9418698/128711626/[t/c]/gaaacgattagaggtatttattgtggcgagggctcatctgtagtgt ttcagttttacttg[c/t]caagtgctcaccttggctctgctacagcatagatgtcgtcagggtggggctttggagtcc/ c/DOCK1/dedicator of cytokinesis 1 3684/7/rs4719913/27899757/[c/t]/ccccctttcctctttacttagttgactcctatttatctttcaaaggaa gcctttcctgac[t/c]gggtcaaacttctctccggatgccctcctatcacagaattctatatagcacttgtcatga/c/ JAZF1/JAZF zinc finger 1 3685/2/rs3769696/98625359/[c/t]/tctaaatcctccataaatttgggtacatgaacttttggacgatttcat ccattccttcac[c/t]cttctgtagtccatgtttttgtgtggcctctaattcttcagttgcttcccctagaatctc/t/ MGAT4A/"mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransfer 10 ase, isozyme A" 3686/1/rs883379/17856376/[a/g]/gggcagggctaaccgtgtttggactgctgtgctccagggcaggggtaaa gtgcttaatgc[a/g]tgtgtgttatcttaattctcatgcaccccttgagaatttcctttgctttactgagatgat/g/A RHGEF10L/Rho guanine nucleotide exchange factor (GEF) 10-like 3687/21/rs2026272/40608009/[g/t]/ccgcagacagcaaggaagtgcagccatggcgcttctcttatttcgta ttatcactatgac[g/t]gctgtctgctttcaaaagcagttgggagctagaactcaaaattgcaagtacagccagagg/t /DSCAM/Down syndrome cell adhesion molecule 3688/5/rs329302/133905576/[g/a]/ctcagggctgaagaaagcacttgaccaggagtcaggaccctggacagg gctaaggcctggaggcccagcttcccatctggcccttgcccaatggctggcccttccctcagccagagtgaa[-/a/g]g 20 gggagtgagtgcgggcctccgagctgagagctgaaggcatgggccctgggattcttgggaggctgggctaggatttttgg tggaagtgcgcaaagcctgaagtctgccctgggagctcc/a/PHF15/PHD finger protein 15/ 3689/8/rs1832/27670815/[g/a]/gaatatagggccggatgaactgttgtgcttgtgaattattgggttacatta ttgaattgt[a/g]acccatttaatgacgtgttctgcttagcgtctttaggccccacctaactcttccagctct/g/CCD C25/coiled-coil domain containing 25// 3690/1/rs2039943/102070433/[t/c]/catataatcagtaaaaagttattttcattgaaaacatgtgatttaca aagggatgacttg[c/t]tcagacacaaatttttgtcatcagataaagtggcaatgctaaatggatcagccagctgta/c /OLFM3/olfactomedin 3// 3691/19/rs8105687/3403683/[g/a]/gtctcgctggcctgcgacccagccagccagcaacctggaccggtgagt tgggcggggcgc[a/g]ttcgggcctctcctggcggctccaggtgacctcccgggggccacgtgctcacacgaaggc/a/ 30 NFIC/nuclear factor I/C (CCAAT-binding transcription factor)/ 3692/4/rs6533498/111332237/[a/c]/tggttaactcatttcagaaaataaaatacttggacctgaaatatttc agatcacttaagc[c/a]aagataaattcctgaattgccagaatggtgccacactcattttactttgttgtctaaaga/a /ELOVL6/"ELOVL family member 6, elongation of long chain fatty acids (FEN1"/"Elo 2, SUR4"/"Elo3-like, yeast)" 3693/18/rs6506345/5886376/[a/g]/cagcaagcattaaaaggaaaactataattctccaggaatcaggaatca gggttggaatca[g/a]agaggggaggtgggggtagggaggatgtccaaactccctacgtcatttaaaaaagagaga/a/ LOC729309/hypothetical protein LOC729309// 3694/3/rs2037580/155558851/[c/t]/atttttcaaggaaaaaaagtgatttcattgaggctactttgccaaaa tagccatagaatg[c/t]tggaataggaagacataagagatactttggggtttatttagcccaacttctttcttttat/t 40 /GPR149/G protein-coupled receptor 149// 3695/20/rs157106/55700177/[a/g]/cagcagaggtgggaataggacaggggaggcaggaccctcaccctcact ctcacccctctc[a/g]gaggaagaagctgcgagctaaggctgggtgcaccatctcccggtccagactgtccatttc/g/ TMEPAI/transmembrane// 3696/3/rs9823492/143893977/[g/a]/acttctaagattgctttagctgtctataatccagacaacattttcca atctggaacacat[a/g]tatctttgtaatgctttaccatggctgttgcacaaatgcatagtgcctctagctttgagc/g /PLS1/plastin 1 (I isoform)// 3697/2/rs6432957/167499892/[g/a]/gcatttattaaatactttcagaggagttctattataattgggtacat tgatgatcctgaa[g/a]ctgtgattgtgctaatgaagtttttgaaatttattatggtatgttaagaaatgtctaata/g /XIRP2/xin actin-binding repeat containing 2// 50 (266) JP 2010-88432 A 2010.4.22 3698/8/rs6473055/51369093/[a/g]/atataacttttgctatctctagagaaaaacaatttatgctgtgacatt actggaaagaac[g/a]tcttatcaagaaaaaattatgacctaaacaatgatgataaattaatttacgatctgttat/g/ SNTG1/"syntrophin, gamma 1"// 3699/2/rs2694618/61390488/[g/a]/gacaagttataaaccttccctacagatgtatacagcctaatttgggga tatcagtgggaa[a/g]gttctcaagtgtatgtatcagcgcagttaagacacatcctattgctaaaatgttgataaa/a/ USP34/ubiquitin specific peptidase 34// 3700/9/rs4744376/96616913/[a/g]/gaaccagttggtctcccggtattcgggtaagtatggcataaggatttt gcactgtcggac[g/a]taagggaattacagcctcattaatggctctcaagtcttgaactagacggtactctgtttg/g/ C9orf3/chromosome 9 open reading frame 3// 3701/10/rs2057435/77344641/[a/g]/atatattagtagacaggtgttattttagaaatacagggcaacatgac 10 ctcttgtgttgta[a/g]cctatacaaaggtaaaagtctatatggtgttatttaatgacaaaagaaaaataaaatcct/a /C10orf11/chromosome 10 open reading frame 11// 3702/6/rs6453850/76703920/[a/g]/tataagattcctttttgtaaagaagttatagggtagagttgaagatgg cacacaaatctg[a/g]ctttgaattccatctgcagcgtttggtaatagtttgaccagcaaaagacaaattacttat/g/ IMPG1/interphotoreceptor matrix proteoglycan 1// 3703/6/rs1929088/6352184/[g/t]/tttttgttgcagtgggcaagtgccacatataaacttcatgtggaaatat gcacaaatacc[g/t]aacagcgggcattcaaacacacttgtttgaagatgctaagctttttataatactttcttc/g/R P3-398D13.1/hypothetical protein FLJ33708// 3704/3/rs9851393/54309763/[g/a]/tttctgagtataagtatgaccaataatgtcattgtcaccaattctgat tttggatgatca[a/g]ttgggtcagtggggtctttttaaagtaacttaaccatgctgggtgtggtggctaacatct/g/ 20 CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 3705/6/rs809419/24634969/[a/g]/ggaaaatggaggaagtgacattaccaagtaaataatagatggaaacttc tcagagttagg[g/a]gaaaataattattctgcagattgaaagatttcactgcttaccaagtaggatgaatgaaaa/a/A LDH5A1/aldehyde dehydrogenase 5 family/ 3706/2/rs755503/134860924/[g/a]/ggggtagagaagtagttctatatgcttaggaaatatgtatatatggga tatctcaaaata[a/g]ggaaaagttggagtgaagattaaaatagaaaataacaaaatgttaacacactaagactac/a/ MGAT5/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransfer ase"/ 3707/18/rs4939804/44523898/[a/g]/tatgccttatatagtcaaactttagcctgcagtttagtgtgtactga tgccaaagccaca[a/g]tgtaatggtaatatgtcattttgaaatttctttgtagaaaatcatgcttttgcttttaca/a 30 /KIAA0427/KIAA0427/ 3708/2/rs906648/142204999/[t/g]/tgggagtcaccacactatacctggttcttgccttgaagttattgtttc gtaattccggat[g/t]ggctattagatgataacgtaaagactggcccctttaggagtatttacatgccaaaaagga/g/ LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)/ 3709/7/rs12667386/105533561/[t/c]/attctttcacttttagtgttcatgcattacaatgtgagtgggcctg gatttatggaataa[t/c]ttgtctagttttaaccaaatcaaccttcacaaaattgacccatggctttaaaatgtcttc/ c/SYPL1/synaptophysin-like 1/ 3710/3/rs6779362/198227527/[c/t]/acagagcagacccttcatggcgtgcaggtactcatggcccagccacg cctcataggtctg[t/c]gtggcgatgggcacaagctccgaggtagagtctttgaagagtagatccttctggccatag/c /MFI2/antigen p97 (melanoma associated) identified by monoclonal antibodies 133. 40 2 and 96.5/ 3711/8/rs4504638/10153131/[g/a]/atctgacttgtgtaaacccccataattagtaagcggcagagccagaat ggacgcagggac[g/a]gtctatgtctagagtcgttgttttgaactcctatgctgtgtctctctcaaagagaacaag/g/ MSRA/methionine sulfoxide reductase A/ 3712/10/rs2094405/114705679/[a/g]/gaaatctaggcactttttgcacacagccaggggcacctcgtgggat gtaaggaggcattc[g/a]aaacctggaaagacttctactgtaatctttaaaagcacagcctctggtgcaactattaaa/ a/TCF7L2/"transcription factor 7-like 2 (T-cell specific, HMG-box)"/ 3713/10/rs10509557/90653819/[c/t]/ccctgaaggttggctcggtaattcatggccagactaaaagtatgct taccttgacttctt[t/c]tatagctttctacagacttgaatgaagtgctccacccacacagtagtcagacttgcaacc/ c/STAMBPL1/STAM binding protein-like 1/ 50 (267) JP 2010-88432 A 2010.4.22 3714/2/rs1400819/180082686/[a/c]/gtaaaatgtttgacaaaagcaggttatcattttctagatttccatct gatgctattgatt[a/c]tattttcagtattatatttcttgacagaatcagttggttttttcaaacttacagtattat/c /ZNF385B/zinc finger protein 385B/ 3715/10/rs7915791/37880205/[c/t]/gtcaagctgtagagtaaccatgagccatcacaggcatctgaacagga gactgggatgatc[c/t]ggtttctgatttagaaaaatcacctgggactggagggaggagaatagatgagtggagagg/c /LOC219752/similar to transforming/ 3716/4/rs10014274/169941872/[a/g]/atattaaaaaaaattttggtctgagagctaggagcaagagcttagg gaaaggaggaataa[g/a]aggaggtagttggctaccaacagacatctgaattcttaaccaatgaagagaaaaaatgta/ a/PALLD/palladin/ 3717/8/rs1390248/80701079/[c/t]/actcactagtattggagctaaaataagggagagaacatataaatgaat 10 acaaaggagaca[c/t]tcacctgccttctctttctccttacatagagaaggttgattatctgctattgtgaagttt/c/ STMN2/stathmin-like 2/ 3718/3/rs7645818/36505422/[a/c]/taaaatcctctattaagttgcttatgtcagaacaacgatgcccaaact cttaggcatggg[a/c]tatgagtcctgccattaccctaaaaacccactttcccctgaactccccaagccctataac/a/ STAC/SH3 and cysteine rich domain/ 3719/1/rs2244634/14006741/[c/a]/cctcaaggatgcattcattctttcattcagtcattcagatttccagtg gcccattcttgc[a/c]tcagggactcggcacaggctgttcctggaacactcttcccccaggtggtcttgtggctca/a/ PRDM2/PR domain containing 2/ 3720/4/rs6850639/20620094/[t/c]/atttggatggctttgcaagtgagtgtcaataaaccctgggttcagagc ctccattatgaa[c/t]gaaataattatgaaattgaattctcctgatttcttttggccttaaagactttctttcctt/c/ 20 KCNIP4/Kv channel interacting protein 4 3721/8/rs11136641/3404260/[t/c]/aactgcccttggtgtgaacatgaagacagccatggaatgattgtttgt gatttcaaagac[c/t]aggcatggtctgaacagaggtttaaaggagtaagctgatgggaagaaatactaagtagcc/c/ CSMD1/CUB and Sushi multiple domains 1 3722/3/rs865808/185341633/[t/g]/tgagataccaagaggccaaccaggcagttatggtagactcaaaagaac actggacttaca[g/t]tcagaatacccagattcaggtcccaccattattaccaatgaccttgggcaagaaaatctt/t/ EIF2B5/"eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa" 3723/3/rs843358/185343937/[t/c]/gttgcagggggaactccaggaccacgtggctcagtacctgcatcacct cctttagactta[c/t]gttataggcatacctgtggggagactggggtgacaccagggccttcactggcctttcagc/t/ EIF2B5/"eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa" 30 3724/15/rs10444808/74059877/[a/g]/gttgaatatccctaatccaaaagtctaaaatctgaactacttctga tctcaagcatttag[g/a]ataaaggatactcaacctgtataatcaaatacagcaaatcagcagaaagtataaggaaga/ g/NRG4/neuregulin 4 3725/17/rs2251660/31276650/[g/t]/tgccctgaacagttccaaatgccaagaactggcgaattactactttg gtttcaatgggtg[g/t]tccaaaaggatcatcaaggtaaaccttgtagattttttttcacttaccacactctccttt/t /RDM1/RAD52 motif 1 3726/7/rs2214326/21822676/[g/a]/attccactaaccgaaggcctggacttgatatccatgttgacggatgat gctacaattgcc[g/a]cctggaataacgaaggactgcccagtgacagaatgtccaccgaaaatgccgctatcctaa/a/ DNAH11/"dynein, axonemal, heavy chain 11" 3727/1/rs12134319/223602215/[g/a]/cccaatcagaggaacaaaatgaaactccagaaacgagtcccacaga 40 aatgcagatctatg[g/a]gctgcctgacaaggaattttaaataactgtcataaagttgctcaatgagctaaaataaat/ a/DNAH14/"dynein, axonemal, heavy chain 14" 3728/4/rs4693496/83856392/[g/a]/cctttccctcaaataacacaaagcttctcttccgggtgtcggggagat catttactaggc[a/g]tgggaatcaaagctccctggaagaactcacggagaatgtcagctccttccacacagaagg/a/ SCD5/stearoyl-CoA desaturase 5 3729/16/rs758747/3567359/[t/c]/gatcagggcacttaccacgccaaccaaccaaccgtgtgggggccgagag cagtgcagccc[c/t]gaccttctgcagccccaccgagcccaccggctgtccctgtggctccgggtcctcacctct/t/N LRC3/"NLR family, CARD domain containing 3" 3730/9/rs4242670/27190738/[c/a]/aattacatctggtccaggggtaagaagtggagtgaattagatttggcg tatcaccccaat[a/c]atatgttaaaaataatatatgtgtgttatgttttcctgttggaaaacatttacatgggga/a/ 50 (268) JP 2010-88432 A 2010.4.22 TEK/TEK tyrosine kinase 3731/8/rs6987111/27656369/[a/c]/aaaacaaaacaaaaaaacaaacaaaaacaaatttacctttctttagtt tcctctgagctc[a/c]atttccattagtccaactacctccctgacatctttttggagatctcaagggtattttcag/a/ CCDC25/coiled-coil domain containing 25 3732/8/rs1460225/27664653/[a/c]/gggccaagaataaggcctccaaagctcttttaacaaagacatgtctgc tagccagcagca[a/c]tggaagggataaggacatgtgaaggaagttggaacacagaaggaaagaatataatgattg/a/ CCDC25/coiled-coil domain containing 25 3733/9/rs10813281/30514250/[t/c]/agtgttagtgtatgaaggcaaggacaagcactggtagctagcaagca actgcaatggcac[c/t]caggaacatacaatgcttcataagaggcaccattgctctgcaaaaaggttggaagacatc/c /LOC401497/similar to PRO2738 10 3734/7/rs2727464/129289697/[g/a]/ggacttcctgagaaagtgacttgctttgaaggaggtgaaagaggagc cacctggtaccaa[g/a]aggagaggagaaggtcactatagagggaacagccaagtgcaaagcacattaggagcttgc/g /UBE2H/"ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)" 3735/9/rs3410/27316060/[a/g]/tgtaatctttaacagggatgttaaaggtaagaagtcaggaagataaaccaa aatgattga[g/a]tatgataaagaattttgcatggcgattaaaatagaaaacctataaatgtagaaaaagcag/a/MOB KL2B/"MOB1, Mps One Binder kinase activator-like 2B (yeast)" 3736/11/rs3819331/111604620/[c/t]/gtttgggaaatgcaacaatccaaatggccatgggcacaattataaa ggtgagagaaaaac[c/t]gatgacatttcagcccttcaataaggatgaaagagtattcagcaaatgtagacataaaga/ c/PTS/6-pyruvoyltetrahydropterin synthase 3737/6/rs12193738/24676372/[c/t]/catggcagagcctgtgcctcaggctgcagccactctcccagcgtccc 20 acactcttgccat[c/t]ctacaatgcttgaacctttccatccagccaggctcttatactcctctgcacttcaacacg/c /KIAA0319/KIAA0319 3738/2/rs1394782/212909165/[g/a]/cattaaattcgtgttttaccatacttcaatttgttttcattgtgttt ttggcttatctgt[a/g]acagcttttcaatcagcttcctttaattgaggacttgacttggtttctaacttttagcat/g /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 3739/3/rs2250952/67710973/[t/g]/tcttgagagggtatccttcctgatcttggcctttaggtctttgggcaa atggaactataa[g/t]tccattgttcagtaaaattgaatgagaaagtgcatataaaatatgtagcatgatggctgg/t/ SUCLG2/"succinate-CoA ligase, GDP-forming, beta subunit" 3740/9/rs10962912/17209242/[c/t]/taaacaggagtttgtctcagtcattgatcatcatcagctcctggcag tgtcttttttttt[c/t]tttttaaggaacctttttttttttaggtcttgtaagtacatagaagtacatgtattaatt/c 30 /C9orf39/chromosome 9 open reading frame 39 3741/10/rs4746718/63836213/[g/a]/ctttataatatttaatggtgtgatgacttgactcatatctgccttcc ccactgttctgtc[a/g]tttccataaaaaggggccaagtctgtaccttttatccctagtatgtccccagtgccagat/g /ZNF365/zinc finger protein 365 3742/12/rs7953019/15512683/[c/t]/tgttattttggtttctcatccacattgtgctttctccagcacccagg ccttcacattcac[t/c]gtccttaggtcctgttctttctctccaactaatcatcaggtcaactcttaccagcccata/t /PTPRO/"protein tyrosine phosphatase, receptor type, O" 3743/5/rs40721/9221231/[t/c]/actctgctgtacttacggctctcctcctgtcacaccttccttttcagatcc ccaccccac[c/t]ccatctcacttcagcttctcacctcttgggcaactttcagtggagtgggcagtgagaggg/c/SEM A5A/"sema domain, seven thrombospondin repeats (type 1 and type 1-like), transme 40 mbrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A" 3744/15/rs6495228/31803566/[g/a]/atggcagtgcctgccaaccttcctcacacctcccctctgttggttct ctcagcagcacgg[a/g]ggacgatgaagaggaagaagaaatcgtgcatatgggcaatgcaattatgtcattttattc/a /RYR3/ryanodine receptor 3 3745/10/rs870353/49467478/[t/g]/tgtctctatttcattatgaatcccagg[g/t]cgttatttctgcccgg atcttactcaggagcttcagactcatgtgtcaaaccatctgcag/g/ARHGAP22/Rho GTPase activating pr otein 22 3746/10/rs7075804/49457051/[t/c]/tttgtttattcctctctcttttttagacccaatctcacactttctat tttaagggataga[t/c]gaatctaacctattcatgtttattatgagaaacaaaatgtttgtaccttcttttgccatc/c /ARHGAP22/Rho GTPase activating protein 22 50 (269) JP 2010-88432 A 2010.4.22 3747/10/rs1838577/49448428/[g/a]/tgagttaattaggaactgagcttcacactcccattagtgctgcagaa gaaaaattcaaca[a/g]cagatatttccttttttaaaatgtcctgggggacaacttgaaatgcttcttctgtgaaga/a /ARHGAP22/Rho GTPase activating protein 22 3748/3/rs6796887/116478304/[t/g]/gctttttaattttgttttcttgtacccagagaattacgattcaaact ttaggaactcaca[g/t]tattgacagcattttagacttaaagagaaccaggatgctggataagcctgacttttaggg/g /LOC645207/similar to Eukaryotic translation initiation factor 4E type 3 (eIF4E type 3) (eIF-4E type 3) (mRNA cap-binding protein type 3) (Eukaryotic translatio n initiation factor 4E-like 3) (Eukaryotic translation initiation factor 4E homo logous protein) (mR... 3749/1/rs4233511/154880141/[c/a]/gagacctggtcttaactctctgggttgggtctatgaagactgtgagg 10 gagatggacatcc[c/a]gggtcagacagaaatgatgtgacaagaggaaagtttcctgaacagctcaagaaattcaaa/a /BCAN/brevican 3750/11/rs7946009/127892632/[t/c]/tgtgaagcataaaagtgctcttttatctggctgtgcccagcacaca atgcaggctcgatg[c/t]gtgcttcagaaatatcccaacaacttttgaatgacaagaacctaccaccttcaatgcaag/ c/ETS1/v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 3751/16/rs1019800/75906703/[a/c]/tcttaaaactatgaaactggcacttagtgggtttctctgattgcctc cacagagggtctc[a/c]aatgtcatcaagggaataaagtagcaaagcctattgtaaactgaatttgcatagctcttg/c /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3752/18/rs2139868/4205843/[g/a]/ttcagtgaattttcagtctgcatcttcctacccaaatgtgttcctgct cccacttttggc[g/a]ggagaaatggaccaccaacatcaggaggagatgcactgccagagatgtgatgttttacct/a/ 20 LOC388458/hypothetical gene supported by BC040718 3753/2/rs12614597/2111801/[t/c]/tgtgtcaatgtggcgactgataatagaaagaaaagccattaattttgg tatgttttttgt[c/t]tccaaccactgtattcagttttctactaattttaatattccttggaagagtctctcttct/t/ MYT1L/myelin transcription factor 1-like 3754/16/rs2303785/56495289/[g/a]/cctactaccgcagctgcatggacagcacggtgaagtacatgaatttc tacaagatcccca[a/g]gtccgtgcagaaccgcgtcaagacctggtacgagtacacctggcactcgcaaggcatgct/g /CNGB1/cyclic nucleotide gated channel beta 1 3755/20/rs6088565/32718647/[c/a]/atgagccactatgcctggccaataattcttagttaccttggtatact tttcctatgggtg[a/c]taataaaagcatatcatcctgtataagacaaatattatttttcagtttcccgtatcaata/c /PIGU/"phosphatidylinositol glycan anchor biosynthesis, class U" 30 3756/13/rs7332615/72263161/[g/a]/gagaagagggacttgacgatgcaagaggagggatttacttgcatatg ttatggattggct[g/a]tgaaattcatgtatttttgtttgtttgtttgtttgtttgtttgtttgttttagatggagt/a /PIBF1/progesterone immunomodulatory binding factor 1 3757/14/rs1147446/65531731/[t/g]/aaagagaagttgaaagtggcctcagatgcattctctgtggagatcag aaaagagacatct[g/t]gaagacctggtgttactaaagaaacaaacttgtcactcttcatcaacaccctcagccact/t /LOC729850/hypothetical protein LOC729850 3758/3/rs13100100/33683118/[c/t]/ccatcgtatggatttaccacattttgtttatctattcaccaagtaat ggacatatgtaga[t/c]gtggggtgtctctattttttggctattataaataatgctgttatgaacacctgtgtgtag/t /CLASP2/cytoplasmic linker associated protein 2 3759/6/rs6931927/143597244/[a/g]/gttgcttttgtcaattgccttctttcagaaatagattagagtgatga 40 gtgagaatgccat[a/g]aatatcctaagggagttccccaaagaaaagagaaaatccttcagagttcccccacctggt/g /AIG1/androgen-induced 1 3760/6/rs4896628/143599392/[c/t]/ggatataatgatgttgttctttgcactttagagagcttcacaccaag ttcctgccccctt[c/t]tgagcgagtcacactctttatgggacttgtttgaagtccagccaagctggcaaccgtggg/t /AIG1/androgen-induced 1 3761/11/rs7932404/3844810/[g/a]/gttggctgtagtacatatcctcagtacctatgagagtgctggtcagag agtatgtgccca[g/a]tagatatttgttgaccaaatgaataacaatgaattgatctttggattgagtaggtgggga/a/ STIM1/stromal interaction molecule 1 3762/1/rs1539053/57872295/[t/c]/ctaggatttcttactttcagtttccctgcctttctgcactaactgcct agattaacccca[c/t]ggtccaggatgcgccagccatggcacactgtaagtttatatttgcaattctggtctcaat/c/ 50 (270) JP 2010-88432 A 2010.4.22 DAB1/disabled homolog 1 (Drosophila) 3763/10/rs2057436/77347493/[g/a]/ccagaatggtgcaatgagttctttatacctcacaacatggcaggaac atttaaaaaacaa[a/g]gtaaaaggaagtcactgggagcaaacagaagaagtgaagagctgacttagagcacagtga/g /C10orf11/chromosome 10 open reading frame 11 3764/9/rs3824544/131988371/[t/c]/gctggctggatttctggccctgctggcattcacagtttggcggggag gcagatgtcaggc[t/c]gggataagcgtcaagacagggctttgcacaatggactgggaatctccctggtctggggtg/t /FREQ/frequenin homolog (Drosophila) 3765/12/rs762718/11835595/[g/a]/aattaacttcctcctctgatgaatgttgacagtcttcctgccataggg atgttgtccaaa[a/g]tacgtgttcatgtgtatgtcaaactagagcttctcaggaggaaagctctttgtccattga/g/ ETV6/ets variant gene 6 (TEL oncogene) 10 3766/17/rs11077773/70571668/[t/c]/ggaccctttgatggcttggagtggggaaggctgtttctttgaaagt tgccaaatgtgtta[t/c]gttgtgtctcagagagagttatttctgtgactctcttggaaatgccttgactgaatgtgc/ t/KCTD2/potassium channel tetramerisation domain containing 2 3767/4/rs4697522/24617621/[t/c]/gagatttaaattcagataatttggcctcagtctatactctgataccaa agaatcaaaaag[c/t]acaaagaagaaaatacaaaccagttgtactataaatgtgaaataacacttaatatcttga/c/ LGI2/"leucine-rich repeat LGI family, member 2" 3768/8/rs7813723/142296265/[c/t]/atgggaatttcgatgcttctccccaaggggtggccctgttttgaggg acccagaagtcag[c/t]gcgactgatggccccagcttctaaggtgcaggattctctcgtctgcatttctaatcactg/t /SLC45A4/"solute carrier family 45, member 4" 3769/19/rs269940/60132169/[g/a]/agaatctaggattacagtcatagctgagattacaggaacaagacacca 20 ggtaatccaccc[g/a]tttgcattgagcttttgagtctttggaaataaaggtatcacggtctggcttgaggcttga/g/ NLRP7/"NLR family, pyrin domain containing 7" 3770/5/rs3777281/9230932/[c/t]/tttgactttgaacccagccttagcaccctattagaactctaaaactaag catgaggatac[c/t]ggaaatggacacacggggacacatgtcaagaatcaccatccaacagatgaaatggattag/c/S EMA5A/"sema domain, seven thrombospondin repeats (type 1 and type 1-like), trans membrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A" 3771/6/rs2298017/70634545/[c/t]/gaagatgggactgagtcgtcttggaattggggattgagggaggtggcg caatttatttcc[t/c]ttactcttccatctcccaatctcaagctgtggccgatgatcactctcttgcctctattca/c/ COL19A1/"collagen, type XIX, alpha 1" 3772/9/rs7852779/16802767/[c/t]/aaatttatttttaaaaactaacattccagttggattcattcaaaatac 30 gtttagctataa[c/t]ttctgaaaaatgttaagcaacaaaaataaaataaaaataaaactgctaattaacaggaca/c/ BNC2/basonuclin 2 3773/10/rs2659998/67963084/[a/g]/gtgtgataaatgctcaaccgtgacaatctaggaaactgacctagatt taataaagttttc[a/g]tgagaaaataatgctttaggtgagccctgctggataaattggagttagctaacaagaggt/a /CTNNA3/"catenin (cadherin-associated protein), alpha 3" 3774/1/rs11807525/188937320/[g/a]/aaacagaaggtgtatcttatcaatagtaatcaaaagagagctgtac tgcctaggttaatt[a/g]cacaatatagactaaagtctatataaagaaaacttccaatgataaaagaagacattgcct/ a/LOC440704/hypothetical gene supported by BC042042 3775/6/rs990386/102035896/[t/c]/gtgggaactatttaattattaattgataatggtcactctaattatagc aaaatatgaggg[c/t]tccttttggatttgcttagagtgcactggctgaagtagaatagccttctgcattaatttc/t/ 40 GRIK2/"glutamate receptor, ionotropic, kainate 2" 3776/9/rs515380/4026449/[a/g]/gataggatataaataaacagatgtataaataaagagtgggtttttgaaaa atgattgaca[a/g]cttgaattgaaagcaagactcctgttgtgaaagaagtagagaactcagcccaaattggta/a/GL IS3/GLIS family zinc finger 3 3777/1/rs171980/180693220/[t/g]/ccttgtcactggctgtgaggtgctgaaggaaggtgatgttgctgtctg catgttacaatt[t/g]taagtctgtaaaggagactcagtccttagggatctctctctgctctgcactcagtgtgta/t/ RGSL2/regulator of G-protein signaling like 2 3778/13/rs9523366/91035934/[g/t]/ttgtgtttggggggtggagggagcagctgcaagaaggaccacaaaga agtcttccaagat[g/t]ctggtgatggtgctttttgtgagtgtttgtctgaactgtccactgcttatgtgtgttatg/g /GPC5/glypican 5 50 (271) JP 2010-88432 A 2010.4.22 3779/11/rs4620711/43670419/[g/a]/ctttgtctaaccagccttggtttattttcaatctagcatttttagat gtatagcacttga[a/g]gtttcagaagaaggagaaaaaacagttcacaaattattttgcaaagtagaacaaaaaata/g /HSD17B12/hydroxysteroid (17-beta) dehydrogenase 12 3780/7/rs2040908/80297952/[c/a]/cctagggagactcagtaactggaaggttatcaggctgcaccatgctca gcacccaagcc[a/c]cctgtttccaaagacctttcacccaggcccttgttattaatgacctgtcttttgttcttg/c/S EMA3C/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (s emaphorin) 3C" 3781/3/rs10937101/183996408/[g/t]/tgaatcaccacgactttcagcaatgggtttattttaaaatgcagat aactaggacaaatt[t/g]ggggaaattgacaagcaaatcctaaggacaggttggagttataagcatatttaattcgtt/ g/ATP11B/"ATPase, class VI, type 11B" 10 3782/9/rs10119236/8506194/[a/g]/aaaaagcaatctcataatagttaaccacttttagtcaagaaaaagcaa aacaagatttac[g/a]gatgtctacatttcccaatgagaagcttttttggtaagaacagcctacagtatttttttt/a/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 3783/16/rs8059032/75915970/[g/a]/caagatagacaaaggcttagtccttgtggaacctaaattcttgtggg gaggaagataaca[g/a]ataaatgaccacataaaaatacatccatgcactgagaagagctatgaagaataaaacggg/a /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 3784/18/rs7227797/44377669/[g/a]/aagggaaccacagcctccagcgggagacagacctgtgactggataga tgaccagtcagct[a/g]acagtcaccagaaagccagccctgggaaggaaggcatgcaggctgggacttgaagggtag/a /KIAA0427/KIAA0427 3785/12/rs7955866/4349810/[a/g]/agggtgcccttccagcgaccctagatgaacttggcgaaggggcggcag 20 ccttccgggccc[a/g]ttcccccagcgtgcgtgttcactcgaccgcccctgaccacccctaatgggtcactggcca/g/ FGF23/fibroblast growth factor 23 3786/6/rs3135021/33153536/[a/g]/acttttcctgcttacacccttcctcctagacctctccacacccctcct aggacacaccta[g/a]aaggtactgacatcatgtcacctcctcatctttcagggtagcaaggttggaatctcctga/a/ HLA-DPB1/"major histocompatibility complex, class II, DP beta 1" 3787/11/rs486992/100490054/[a/g]/ttacaaaaaagttgccacaaactttgaaattacaataatttttaaga tttaatattttta[a/g]tctaatacttagtcaggattcagactttctccttccataccccgcatttaaacaccaggg/a /PGR/progesterone receptor 3788/11/rs543215/100479243/[a/g]/gaaataataaagtgcgtggaaattcccaaggatggagcagatctaaa tagtctttggact[g/a]gaatctaagacgacacagaatatactggctagagaacagaccactgggcactgaacacca/a 30 /PGR/progesterone receptor 3789/11/rs1518821/43828572/[t/g]/gggaaaatgaagacccagaatacactagggtctagtgtatttgcaca gtatgagatttca[g/t]acatggtgtcacatctgcctttaccgagcattaaattcaaccgtgtagccagcacacact/t /HSD17B12/hydroxysteroid (17-beta) dehydrogenase 12 3790/10/rs1380439/127758100/[t/c]/gccacatggtagcatgcatcggaacctcattccttcttatggctgg atgatattccattg[c/t]aagtgagaccataccacaatttgctatctgctcatctgttaatgatccaggtgattttga/ t/ADAM12/ADAM metallopeptidase domain 12 (meltrin alpha) 3791/5/rs2561143/38307208/[t/c]/taaatgcaacagtgataggattagaacttcattttgggaagactattc tggtagagagta[t/c]ggttgaagcaaaatgaaggcggagaacacatcatagaaatagcatcttttacatttattc/t/ EGFLAM/"EGF-like, fibronectin type III and laminin G domains" 40 3792/21/rs2826725/21481598/[g/t]/attagttcacatagtcatgctgcaccacatactttttaacgtttctt tccctggtgagtt[t/g]tagcctccaacctccatattgtacttctccatcaacaacaacaacaacaacaacaaaaaa/t /NCAM2/neural cell adhesion molecule 2 3793/1/rs1934346/238832099/[c/t]/cttaggtaccaaataaaacactttgcctccctagaaattttcagagc ttgcccaggcccc[t/c]aaaagctattttctgtcaacacttccactaagctgaacaggaagagaggttgcttgtctt/c /GREM2/gremlin 2 3794/12/rs10877760/60569006/[c/t]/attccaaaaggtggactcagttattttcaacaaaagcttttttaat gctacccctctcca[c/t]tggaggctaaactcccctggagtggttggagactgtgtttccagcagcaatgggctggcc/ c/FAM19A2/"family with sequence similarity 19 (chemokine (C-C motif)-like), memb er A2" 50 (272) JP 2010-88432 A 2010.4.22 3795/3/rs3774388/42232079/[g/t]/tgtactggttgaggagtttatagaacttgcaaagcagatccaagtcat gtgacagcagca[g/t]cccactacatgcttaagtcaaggaaagaaaggtcagggtcatagggtttattttacacaa/g/ TRAK1/"trafficking protein, kinesin binding 1" 3796/13/rs7317678/99338531/[a/g]/agttaacactactgaactgcacacttaaaaatgtctaagatggtgaa ttttatgttttat[g/a]tttttgccacaactaaaaagaaaaagttttactggggttggataatggtatctacttcaa/a /CLYBL/citrate lyase beta like 3797/6/rs225699/142572730/[c/t]/ctacagattctgtgcaatccctatcaaaatgccaaagacattcttcac agaatgacattt[t/c]accaaaaaaaagaaccctaagatttatgtagaatgatagaagaccctgaatagtaaaagc/c/ VTA1/Vps20-associated 1 homolog (S. cerevisiae) 3798/4/rs4699831/96185917/[t/c]/tcactgttttttccatgtttcctcagcatagcaggcagttactgtact 10 gcattgtcatta[c/t]tggattgtatgtttgtcttcacccactagaggataagctttgtcctgaaggcaagtgctg/t/ BMPR1B/"bone morphogenetic protein receptor, type IB" 3799/4/rs7694043/96157791/[t/c]/tgtcagtcacaggtaatgtttgaggtgtttcctagacagatgaatctt ggcacttagcat[c/t]agtatttcaatatttcatcagtatttcagtgttgccctaaaaactttcctttaagcctgt/t/ BMPR1B/"bone morphogenetic protein receptor, type IB" 3800/5/rs7446531/146091073/[c/t]/ttgccagttactggcacttaaaatggctgcaaaatctgtggtactgc tgggtacctgatg[t/c]ttgctgcagcctcaggactctgatgcctggactttttcagggtcttatagtatccattgg/t /PPP2R2B/"protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isofor m" 3801/1/rs11801346/188900774/[a/g]/ctggagatacatgttaagtattctgtatatctttaagggcctggtc 20 agaatggttatgaa[g/a]ttttctccagccatgcttacctacaccatgggtttcagaacaatgtagactcagaggaag/ g/LOC440704/hypothetical gene supported by BC042042 3802/1/rs10914782/34040532/[t/c]/aggatgcactggggtgtttttatttcccttactcctagtttattgag tacagacatatcc[c/t]taacttgcctctccaataagactgtaagttcttcctgttcccacagtgcagaggcgcaca/t /CSMD2/CUB and Sushi multiple domains 2 3803/10/rs7078010/89586538/[t/g]/gttattctttcaaatatttggtactacgttgtattctttcctttctt cttctggatctcc[g/t]atatcataaatgttagatattttggtggtgtcccaccagtccctcaggcacagctttttt/t /CFLP1/cofilin pseudogene 1 3804/10/rs9971071/28738040/[c/t]/ccgttagtgaaagacactgcttcctgcccagagcatcacccaccttg acagctaccttct[t/c]caaggagaaaaacacctcaaaaaattactgtgtatgtttttatgcccggtctggttggtg/t 30 /RPSAP10/ribosomal protein SA pseudogene 10 3805/11/rs2407047/98993821/[a/g]/ctaacagttcatctatagtgccctacacatagttttatcacagaatt tattacctacttt[a/g]ttcattattggttaacattcccatgtcctgtactagagaacatattactcaacaacaaag/g /CNTN5/contactin 5 3806/11/rs925149/94472789/[a/g]/ataaaagttttttatggttcacaaacttggctttcttttccctgtgtt tctgcgtgtccc[a/g]agaacatagtggatgcccaatctttcagaaacatcaaccgtagatatttcattatggggt/g/ ENDOD1/endonuclease domain containing 1 3807/11/rs765386/129794818/[t/c]/ttcaatagtcatatatggctcgtggctactgcactggaatgtgcaga tacaaagttctac[t/c]ggacggcatggcttattctgccttaatcctgacaccgtctccttgccaaccacccccacc/c /ADAMTS8/"ADAM metallopeptidase with thrombospondin type 1 motif, 8" 40 3808/11/rs1562353/3120229/[t/c]/tgggcccttgtggcagcagggcatggaggggt[c/t]gtggtggagag gtaggggcttcccagttgtacagaccagcagcccagaaagtgttctctt/c/OSBPL5/oxysterol binding pro tein-like 5 3809/3/rs1356240/2848869/[t/c]/ctttttaaaagaaatctattcctttaaccttgaaatcctaatttacata atccattagaa[c/t]ccaatcataaatttcattcatcacaactgtgtccattgaagtaaactggagttgtacatt/c/C NTN4/contactin 4 3810/6/rs7767578/6354844/[t/c]/cccctcccctttgcactgggcatttcagatgtggttttgcattcatttg tgtgattcctc[c/t]ataagcggatgtctccacactgctcctgagggcaagaaccaggtctgcattcactgggca/t/R P3-398D13.1/hypothetical protein FLJ33708 3811/13/rs983130/31720975/[a/g]/gctattttttctctgcaatttgagtttgttgtgttctaaagaggtaca 50 (273) JP 2010-88432 A 2010.4.22 aaaaaacatgca[a/g]ctggttagcagcatgctccagagacccagaactgccccagaatgatgggtctcaggagcc/a/ FRY/furry homolog (Drosophila) 3812/16/rs4522429/20293616/[g/a]/tcacccttgacagcgtcctggtgttcaaaaaggtaggattttgatcc tattgctagtgag[g/a]ggtctctggttcaaagtagtggaatcgtatgagctttgggtacaaattctggttctgcca/a /PDILT/protein disulfide isomerase-like protein of the testis 3813/2/rs3732178/61126705/[a/g]/ggaggagtcaggaagaaatgccccagcagagttattcgaatactattt cactgagataag[a/g]aaaggctttgtttatataggcttttctaaactcaaaatacttgaatttcaaactgttaat/g/ PEX13/peroxisome biogenesis factor 13 3814/3/rs355762/155495308/[g/a]/ctgtagatcataacattatcctgcctctgagaatgtagtgttcactct aattaggaaagc[a/g]cctgtatctgatggagccaaacattcataatacattattaaaacagaaattttatacctg/a/ 10 DHX36/DEAH (Asp-Glu-Ala-His) box polypeptide 36 3815/4/rs7672034/187075206/[c/t]/gggagggtagaggggctgaaggttaagtggatcaccaatggccaatg gtttaattaatca[c/t]gcctatctaacaaatactctataaagtccctgaggacagggtttgggaagcttctggaga/t /SORBS2/sorbin and SH3 domain containing 2 3816/13/rs913466/50515731/[c/a]/tcacacagctggtgtgacggaaaagaatccaccctccattctcattct ggaataacaacg[a/c]gatgttctttcgcagagggctcagaccaaatcaagactacacgatacagccactacgtcc/a/ GUCY1B2/"guanylate cyclase 1, soluble, beta 2" 3817/1/rs7520966/54417850/[t/c]/gcatgtgaggtttgggtaatggagatgatgggatatggggactgaaag ggaacataacag[t/c]atagcccatcctgtaagtggcctggttgcctactaaagcatccccacaaggactctgctt/c/ LOC606495/hypothetical protein LOC606495 20 3818/15/rs2414428/53794987/[c/t]/aatccttatgcctaaaagcaggagcgtgaagccctgagcagacgtgg ggccttgagagta[c/t]gtgaagcatttgcaaaagtgacctcagggcaactccaagccctaacggatactttagtgt/t /PRTG/protogenin homolog (Gallus gallus) 3819/11/rs9666607/35182731/[a/g]/ctacccagaaggaacagtggtttggcaacagatggcatgagggatat cgccaaacaccca[a/g]agaagactcccattcgacaacagggacagctggtaatggatggtttaacaagtaaatttg/g /CD44/CD44 molecule (Indian blood group) 3820/5/rs6874089/58510611/[a/g]/aagtgcatagaaacagagggatccggttccacacctccaactcagttt agactcatttat[g/a]ttgaatttgaattttggcagaagaaatcagttactcaaagtatttattttagcatatagg/g/ PDE4D/phosphodiesterase 4D 3821/2/rs2321733/134778532/[a/g]/caaatattcatctgggaacagactacttgctgaaacgaacaaattcc 30 caggcagttgaaa[a/g]cctttgtgtttcctactgggaataacctgcattcacaaattcattagccttttatgtgga/a /MGAT5/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransfe rase" 3822/7/rs2390256/20144407/[t/c]/ttgttacaagattataaaatatatttgtgtgtattaatattagaacca ttgtttcatcct[c/t]aaattacagagatcttgtttttcatttttttaaactcttattattctcaatcacaatcat/c/ 7A5/putative binding protein 7a5 3823/6/rs2571577/129839777/[c/t]/aggagtgcgggggtggaaacagacagacacctgacatgaaataaatc acctgatatacac[c/t]gccaaggtctaatttgtttttccacctgtttttcctcatgccatgtgtttttcattaaga/t /LAMA2/"laminin, alpha 2" 3824/5/rs1439598/124659359/[g/a]/gaatgttgtgagtaccttggaagagaagcaaggtaacttctgcacct 40 cgtccaataatca[a/g]tttacttgggggatttgtcatcagtcctcagagaagtgagtcacagcagttaccatcttc/a /LOC644659/similar to High mobility group protein 1-like 10 (HMG-1L10) 3825/7/rs6463224/1106944/[a/c]/tcccctctgcctccctgcctcccggcctccacaggggcttcttgtggtt aaaaaaaaaaa[c/a]aaaacaaaaccctttctgagcactttacccatctcgcccacaggcagagacgacaccccg/a/C 7orf50/chromosome 7 open reading frame 50 3826/3/rs10511389/120557547/[g/t]/ggctattctagatgaataagacacgggactgtcctcattgtcccca aggagctcacaact[t/g]agtaatggagatgaatcagaaacaagcaacacctcacacttggtgctagacacagagtag/ g/CDGAP/Cdc42 GTPase-activating protein 3827/14/rs1957547/80673891/[t/c]/ttgtctgctagatacactgattgtgtgtgttcatctgaaagagttca tccaagtaatgtg[c/t]ttgcattttaatacatatttcttgagaaaacatgttagtaattatttcagttactgcgtg/c 50 (274) JP 2010-88432 A 2010.4.22 /TSHR/thyroid stimulating hormone receptor 3828/1/rs4908600/7119246/[t/c]/ctttcttattgctactgcctgtctctctccttctgtctgcagcacaaca gcttagatgta[c/t]cacattgtcttattcattttttctggttactcccctccagttcactcttaagctgtctgg/c/C AMTA1/calmodulin binding transcription activator 1 3829/1/rs1355630/214542165/[g/a]/ttaggacattcactcacacattcaccaaatatatatgatcacctccc atgtgcaaagcac[a/g]gagccattttctgtctagattctctatgtagttgggcactttatctgtgttcccctctga/g /USH2A/"Usher syndrome 2A (autosomal recessive, mild)" 3830/7/rs3817530/129374460/[g/t]/tttagcttgaagaccataaagctgtgccaactttcatctcatcatct cactaaaacagag[t/g]ccactggaaataaagaggcaaaccacaggttcccaattgacactagaactagttaaaaga/g /UBE2H/"ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)" 10 3831/4/rs884701/123049856/[c/t]/aattagggcacattgtgatgagtacaaggagcatgttaatgttattga aggctggacttc[c/t]gctccaaaatataagatgtaattaagcacctctgttattctcagcaagcaaagactttta/c/ TRPC3/"transient receptor potential cation channel, subfamily C, member 3" 3832/10/rs1248077/121129035/[g/a]/tgttcatatccccttgttgcctggcgtatctcaagagaaatccttt ctaggggggatggt[g/a]tcttagctcctctacaccaggtagactatagtcatcccttccctgcaagttgctgtcctt/ a/GRK5/G protein-coupled receptor kinase 5 3833/2/rs6714952/58229192/[t/c]/ttatattatttgtttttttatttgaagttcaatttatcaatattttaa tagtttttttgt[c/t]gtttgtttgtttttctgtaaagatacctaagaaacctttgcctacctcaaggtcacaaag/t/ VRK2/vaccinia related kinase 2 3834/22/rs5762758/27439036/[t/c]/ccagcactcagcccccagcccctggcaaccactaatctactttctct 20 aaatattgatttg[c/t]ctattctgaatatttcatattgatgtaatcatacaatatgtagcctttcgtgtctggatt/t /CHEK2/CHK2 checkpoint homolog (S. pombe) 3835/1/rs901675/228456625/[t/c]/acttaaacacacagactgccctgagcattggaactcagtcgaagctta gactgactggtg[c/t]gccttttgtgacacacaggtaccttccaaccaggtacctgcccttatcaccactgactag/c/ GALNT2/UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltran sferase 2 (GalNAc-T2) 3836/11/rs11030106/3838306/[g/a]/ctctctacctctactttagccactctcaaaactttgtgataaatctg caatagaggtatt[a/g]tatatacatgcagaaagctgtgggaagcccagaggagtaagtgactaaccctgcctggga/a /STIM1/stromal interaction molecule 1 3837/9/rs2993129/38553171/[g/a]/catcattgtattttgcaatgtgagaaagacaaatttgcaggggcaggc 30 acagaataatac[g/a]atctggctctgtgtcccactgatgtggaactgtaatgggaaatgttaaaggtggggtgca/g/ ANKRD18A/ankyrin repeat domain 18A 3838/2/rs1919127/27654997/[t/c]/cgcaaacatctccatttgaggaacatacaatattgactcataaacaag ggcttcaggctg[c/t]gaaatctacagtgataaaaacagagcctcctaaagttatggaaactgaggatttgaatct/t/ C2orf16/chromosome 2 open reading frame 16 3839/3/rs1610008/67680446/[c/a]/gtaaaacactatgtgttcagggagtatcttagttcattctggctgccg taaggaaatacc[a/c]gagactgggtggcctataaacaacagaaatttgtttctcatagctttaggggctgggaag/c/ SUCLG2/"succinate-CoA ligase, GDP-forming, beta subunit" 3840/6/rs1340083/164618476/[a/g]/agccacacatatggattcttgactcatgagacaaatgtcattactaa ccatggtgggagg[g/a]gaggatagcttatccaaaatcagctagagagcacttggttattcacagctgaaggaaagg/g 40 /LOC728275/hypothetical protein LOC728275 3841/5/rs6862543/32142841/[g/a]/accacagaaaatgtttttgtccttgtgtgggctggatttcttccaagc tgtatttttatc[a/g]cataatatttatttcaataatttcaataacgactttcagtaatttaggatgaaatcgata/g/ PDZD2/PDZ domain containing 2 3842/10/rs7087438/15049115/[t/c]/ttaacggggagaggcccagaagaatgatttgcaggcagagtgggaga agaggtggtcgtt[t/c]agctgggcacattcagaattttctcttttattgagcaactgtgctctgctaaatgaatct/c /MEIG1/meiosis expressed gene 1 homolog (mouse) 3843/10/rs628116/13078224/[t/c]/atatggagtaggcaacagtaatgattaagaaggagaaaaggaagaata aaaacaggtgct[c/t]agaaccacattgggagcaaactacatgagaagcgttcagaaagttctaactttctaacca/c/ CCDC3/coiled-coil domain containing 3 50 (275) JP 2010-88432 A 2010.4.22 3844/4/rs1400918/138094233/[a/g]/tcttaacaatggactgcatatcccatgccatctatatacttacataa atactatatttat[a/g]tgaacttatgtgaaaagaaacaaggatcactgaagtgtgccacctctccttccatgtaga/a /LOC729578/hypothetical protein LOC729578 3845/11/rs3741353/3085350/[a/g]/acggggctgatcgtgtcaaatgtgggttgtggaggtgacgacaggcag gaacgtatgtga[a/g]gtgcggagcagcgaggggtgggcagcccagagggctgtgctgggctctcacctgtgacag/a/ OSBPL5/oxysterol binding protein-like 5 3846/3/rs6810120/155522740/[c/t]/aatgtgcacagcggtaaacctgttacgttgaagccgtattaccaaga tttccagagaaca[t/c]gtcaagatgcaactgaaatatatcagactgagacagaagtgacatgacttccaatctgaa/t /DHX36/DEAH (Asp-Glu-Ala-His) box polypeptide 36 3847/8/rs10105423/139422897/[t/g]/aaggcaggaactgggttagttaaaatagttagtgtttagtgggttc 10 agagtttcagctgg[g/t]gaagctttaaaagttctggagatggatcatggtgatggttccacaacaatgtgaatgtac/ g/FAM135B/"family with sequence similarity 135, member B" 3848/2/rs2888089/212927526/[c/a]/gtgtacacataaagtccatgttgacatatttacacatacacactagg aaataacttggat[a/c]ttcctgggtatctcattcttacaccagcaatttcaaaagaagcaatgctttttatcttta/c /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)/ 3849/1/rs6656366/213984466/[c/t]/aatgaagaatataatggcattttctattacattgtctccttgatctg agagtttttaaca[c/t]ttatgagtttagttatttacttctgtagtacccacataagtctatctttactttagaaac/t /USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 3850/12/rs7964528/53009051/[c/t]/tctaaataacagtaagttcccttcttttaggtactttacagtgggtc acatggtcacatt[t/c]ctttcttgaattaagtaatccagctctagctttcaagcagatttgtctaatctctctcag/c 20 /COPZ1/"coatomer protein complex, subunit zeta 1"/ 3851/16/rs3935368/25686730/[t/c]/ctgcatatgaaagtgttctctttggtttcttaatggtgccccagtca attagttcattcc[t/c]aatatgctgtgtccctggcactgtgccacccctaagggtgggtacatgaacgagtagagt/c /HS3ST4/heparan sulfate (glucosamine) 3-O-sulfotransferase 4/ 3852/7/rs10260856/37423118/[g/a]/gctcattcacttcctcagtttctccacaaacctagcttatgaaatca aatgactgcaagc[a/g]actagctgtaaaagctaaacccctactgagcactttctatgagcgtgatactctgccaag/a /ELMO1/engulfment and cell motility 1/ 3853/6/rs6455680/160367978/[a/g]/taatgttgttgtacctcaagcagaggatgggtacatttcttgattac aaataacatcata[a/g]cctgtttcctgtgcacctcttatataccagtgcagagccagtactttacagtccttcatc/g /IGF2R/insulin-like growth factor 2 receptor/ 30 3854/16/rs4784650/54864141/[g/a]/agatattggggcaattacttattctctctcagcctcagttttctctt ctgtcaaatgggt[a/g]taataaaatcccaccctttccacctgatcaagtgcatataaagattaatgatatcaatag/g /GNAO1/"guanine nucleotide binding protein (G protein), alpha activating activit y polypeptide O"/ 3855/15/rs8039195/26189679/[t/c]/aaaagtaaacaaaaattcagaaatggtgggaaaaattaaagttaaca caattaaccttta[c/t]ccacgctttatattttggtattgactcatttgacccatcaaatgacaatgtcaatgatac/c /HERC2/hect domain and RLD 2/ 3856/19/rs2288904/10603170/[t/c]/ctgggatcccctgactcacagggtttgctggggatgaggacagcagg gcagtcaccatct[t/c]gaagcacctcagccactccctgccaagagagatggagggaggtgagtccccaagtctagt/c /SLC44A2/"solute carrier family 44, member 2"/ 40 3857/1/rs1417609/119779329/[c/t]/actattggcatcagagtttgtgaagactttctcgatatgataaccat gtgttaaataata[c/t]gctgtagctagttctcctctcttccttttccacaggcggccacaatgtcctgttttgctc/c /LOC391073/similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/ 3858/1/rs11120616/213983186/[a/g]/tctgaaagactttcaccattttgacatgcttgtatccttatctcat actgtgtgaatgga[a/g]tcaaattttccagaagggtggattgatgatgaccaacggagaaggccagaggtgttacac/ g/USH2A/"Usher syndrome 2A (autosomal recessive, mild)"/ 3859/9/rs7045401/4483526/[g/t]/taactgatccagaaaaatcgcaagagctctaatgcagcctcccttttgg acttttcagca[t/g]gtggaacttaaagaagaaaaaaaactgtgaaatttattaactatcatgacaaaacatctt/t/S LC1A1/solute carrier family 1 (neuronal/"epithelial high affinity glutamate tran sporter, system Xag), member 1" 50 (276) JP 2010-88432 A 2010.4.22 3860/1/rs2791398/244032174/[a/g]/agcaacaaaattactgaatacccacagaatggggagatttgacttgg tagtgttcctggc[a/g]tggagttctagaagttctcagtggccacaagctcagcaggagacaactgctgtgaagcca/g /SMYD3/SET and MYND domain containing 3/ 3861/2/rs3087822/46705537/[g/a]/atatggccaaataaatacactgaattttagaaaaacatattactttga attcaaattgtc[a/g]tgaaaaccagaacagtgtttgtccatgttgcatgtaatgaaaataaatccctgctctgag/a/ CRIPT/cysteine-rich PDZ-binding protein/ 3862/1/rs1202812/58154568/[c/t]/gcagtggccagccctcctctctcccagacaatgaaattaccataaaga acttgtcagcca[t/c]gccttcactggtctcttgattccagttttcctatgacttgaatccattcgaacataggca/c/ DAB1/disabled homolog 1 (Drosophila)/ 3863/8/rs2294008/143758933/[c/t]/cccatttgaggccatataaagtcacctgaggccctctccaccacagc 10 ccaccagtgacca[c/t]gaaggctgtgctgcttgccctgttgatggcaggcttggccctgcagccaggtgaggcctt/c /PSCA/prostate stem cell antigen/ 3864/8/rs2920297/143760085/[t/c]/ccgctgagcgtcagaaatggggtgagtgagtaagtgagctcagggat ggggagggacaga[c/t]gggtggaggagtggaagatggaggatggggagggacagatgagtggaggagtggcagatg/t /PSCA/prostate stem cell antigen/ 3865/21/rs222954/26839258/[c/a]/tttgtcaaattaggaattaaaaagggactggtatatctagtagagaaa tgttgtcattta[c/a]tgtgttctgaaacatttaatctactctgaaatgatttgggagttgaggtaaattatcctt/a/ CYYR1/cysteine/tyrosine-rich 1 3866/7/rs17145586/21826841/[g/t]/agaggagagcaggacccagagcacagacttccttggttgatccctag gttggccttttgc[t/g]atgtgttgataatttccaacccctcctaaatacactcaaggggcctgtttttatcagtta/t 20 /DNAH11/"dynein, axonemal, heavy chain 11"/ 3867/10/rs1911355/67948325/[t/c]/ctgaatttactttgtgaagtctatatgaaggagatagcaaatagaca aaaatatgcttaa[c/t]gttgttcataataattaaaattactgtttaaatgttaccaaaagagcacataaatgaata/t /CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 3868/11/rs4755737/43748441/[g/a]/tttacaggatctgttaaccctgggcccagcattcttgcagggcagca atccactggagct[g/a]tgtcctttagatgggaatgctcctgtcaagttagcccagcccactcatatagtgcagcac/g /HSD17B12/hydroxysteroid (17-beta) dehydrogenase 12/ 3869/15/rs4321149/69656526/[a/g]/attacatgattgtcctaacaaaaaaaaaaaaaacctttagtacttta ttaagtatttctc[g/a]tattcaaaattatctcacctgtgtgctgaactagactgtaattccttttgtggaaggaaa/a /THSD4/"thrombospondin, type I, domain containing 4"/ 30 3870/18/rs4939811/44551770/[a/g]/tcagctggctggctccaggagcttccttcactggggaggaaggagca tggataggcaggc[a/g]tgggaatagcacaggccacagccacaaaagggaatggcctggggttttctccctctcgct/a /KIAA0427/KIAA0427/ 3871/5/rs10052776/11231648/[t/c]/gatatgctgggttgaacatcatggaaacaatcatgactatgaaactt cccctactcttaaggagcttataggttaatgtaggtgatagagaggcagagatgatacaacttgaatggaaaa[c/g/t] ctgtgatatgagtcctggtaggaggagtatgattaacaatgcgtcataatggaagatgatgctaacaaaatgaggcaaat gctggttatggaggtctgagaaatttgagatgtaagacat/c/CTNND2/"catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)" 3872/12/rs10846824/124139324/[t/c]/tttgaggagacgcctggccgcgatgccctggacccttcagaggtg agctggttccttgtg[c/t]cccagccattttgtgggtctcagttggatacggatttgacctgatcatagttactaggat 40 /c/AACS/acetoacetyl-CoA synthetase/ 3873/15/rs7179994/25997365/[g/a]/catccaacagcccaggaagaaccacacccggccaacaaccacacaga tgagctcagaagc[a/g]gaccttgctccagctgaacactgagatgctatggttagagccatacatgacaacttgtcc/a /OCA2/oculocutaneous albinism II/ 3874/16/rs4784289/51671757/[a/g]/tcccttccctgtagcctactcacacgcccatcaacatggataactga gaggcatacgcaa[g/a]gtgcggcaatcagtttctagtacagcagtttgttattacagttgctcaagaaatatgtgt/g /CHD9/chromodomain helicase DNA binding protein 9/ 3875/16/rs954044/75898834/[t/c]/gtgagtgattgaatttgacaagagacagtaatacaaagaccctgatca gggatttggaaa[c/t]gcatctgttaggcagcttcaaaggtgtgggctgacacattgaaccttgactacagttcta/c/ ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 50 (277) JP 2010-88432 A 2010.4.22 3876/16/rs274534/75901706/[g/a]/tcttaaacatcccacgatgttccagacactgtgccaattgtggaagct acaagtataaat[a/g]agtcattgtctgataacatagggtttgggggtgctctaaaagtacttcaggacagtagta/a/ ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 3877/18/rs178003/18338754/[g/a]/caaataagtaaaattgatgctttcgtgcctgggccctttaggacaagg aaaagaactcag[g/a]attgcaaactgctagtctgaactagggacttgacatttattatctgagtcactcatgtag/g/ LOC284232/similar to Ankyrin repeat domain protein 18A/ 3878/18/rs494470/18333237/[g/t]/ttctcaaacacagcaattaaaaaaatcaaacaatccaattggaaaacg ggataaaagata[g/t]gaagagacactacaccagagagtgtacacagatggcaaataagaatatgaaaaagatgtc/g/ LOC284232/similar to Ankyrin repeat domain protein 18A/ 3879/1/rs4846444/216077064/[a/c]/agtgcagtacccaaatagaagtaatccctgtaatattttttggatat 10 caaatggcttggc[c/a]tactcaaatgtgactagtttctatatgtcttctgcatgaatgtttagagctcctgaatct/c /SPATA17/spermatogenesis associated 17/ 3880/7/rs10247026/157923356/[c/t]/gtacctactttctctttgggatccagtctcctcagggcctggtaac ctttgcaatgcaaa[c/t]atctatttgtgtgttgatgaccctatgaggttgccaagtgctctgtgggtttcactgcct/ t/PTPRN2/"protein tyrosine phosphatase, receptor type, N polypeptide 2"/ 3881/6/rs4472357/96685008/[g/a]/aacctggtgtgaatgctaatgtcacattaataatgccattagttatat tctctccccacc[g/a]tcatcttgaatgtctcagtgacacaataacatgggctccatttagtgctttaaaaattaa/g/ FUT9/"fucosyltransferase 9 (alpha (1,3) fucosyltransferase)"/ 3882/13/rs1414714/91038793/[g/a]/aatttttaagttagaaagttctcacctattttattttctgtgtgata tgaggag[a/g]atacatcacctgtagagggggaaaaattgtttaggattatctcctctaatcctccaactc/g/GPC5/ 20 glypican 5/ 3883/1/rs2242420/21777116/[t/c]/aggccctgaagcctccgtggaacattctggatctgaccctcccagtct catctcctgacc[c/t]tcccactcccatctccttacctctggaaccccccaggccctacagtgctcatgtccctgt/c/ ALPL/alkaline phosphatase/ 3884/2/rs2673164/169861772/[g/a]/gagttagggagctctgtgcaatctttcctatgagtatacatcccagg ttaactatgcacc[a/g]aagagatcaaggtgtgcaggggttgagaggggtcctctgctgattgagagtgattcttta/a /LRP2/low density lipoprotein-related protein 2/ 3885/19/rs4807471/3399694/[t/c]/gacttcggatctgactgtctctgccctccctgccaccttctctagggc tcgggtgactcc[c/t]aggtgatggggcagccctgagccttcccatttctctggaaggagagtaggcaagggccag/c/ NFIC/nuclear factor I/C (CCAAT-binding transcription factor) 30 3886/19/rs1541925/58798359/[t/c]/tggtgagcagtggcgtttctccgcggggtgttttgaacctgatagca tgcggcagggggc[t/c]gagtagggagtgtggggctttggtagttgagaggagttgtgaagatgtggtggcccttct/c /LOC284379/"solute carrier family 7 (cationic amino acid transporter, y+ system) , member 3 pseudogene"/ 3887/9/rs4979142/114461245/[a/g]/taggtggagccaagtatggaacctagatcttccagtttgaaattcac tgttctttccatt[g/a]tgtcctgctaaggggtcacagaatgtcctcaacacagcccctggtgaggattagaaggaa/a /KIAA1958/KIAA1958/ 3888/6/rs2854028/33287667/[a/g]/gatggtgtactgcttttcactgacgccctccaggctgggcaaagcagg ctcctcaggacc[a/g]tcacctcctccggcacccccaccctccccgccacacccatcaggtcctccggtgtcagag/a/ RING1/ring finger protein 1/ 40 3889/3/rs6550342/35329050/[c/t]/tctaatttgtgcatgtgtatgtgtgcatgtgtgtgggtgtgtgtgtat cataatttacct[t/c]gttgctgtggttttgagctgtttcgatttgaagaaaattacctgacaattttatatgtga/c/ KRT8P18/keratin 8 pseudogene 18/ 3890/18/rs10503139/64851232/[g/t]/ataatcatacattatctagattaacacattgtaaagcaatgtcaat tcttgttagatttt[t/g]taagacatctgtgcccacttatcaaatcaatttttaaagattttaaaagtttatcatata/ g/CCDC102B/coiled-coil domain containing 102B/ 3891/19/rs2561537/45885420/[c/t]/gggtgaactctgggtgtgattctatctgggtgggcctgtgacgtcag tatcttgggcggg[t/c]gcctgaggaaacatagctgtcactgggtgtggccacgcatgtgcggctctagtgggttgt/c /NUMBL/numb homolog (Drosophila)-like/ 3892/2/rs351676/143427735/[t/c]/ccacatagatttctccatttgacagacaaggttgatgaacaagtggtg 50 (278) JP 2010-88432 A 2010.4.22 gatgctaaaaga[c/t]gtatctctgatcactgtaaggtgaataatatctaacgtcaaggggcagtaagaaaaatct/t/ KYNU/kynureninase (L-kynurenine hydrolase)/ 3893/1/rs769163/102076740/[a/g]/tagcttctatctgtataatgaaaagaactttttaatggaatatcagga gaagctagaaaa[a/g]taaaaccatcaagtttattaatacagacacttctagtttacagaatttcaagtctacatg/a/ OLFM3/olfactomedin 3/ 3894/9/rs1442514/17409319/[c/t]/aaaagatttatacttaatttttcttgaaaatagttgatggctatttat atattccatcta[c/t]agaataatgcttagtatagggctatagcgcatttcaaaataggtttagaatattttacaa/c/ C9orf39/chromosome 9 open reading frame 39/ 3895/12/rs2583999/69298785/[c/t]/tcctgactcataccatagacaagtttcctgttctatcgattttgtcc ttgtgaagacacg[t/c]aatccacataatactatttataaaagtgacaataacaacaatggcagctaaaattaatta/c 10 /PTPRB/"protein tyrosine phosphatase, receptor type, B"/ 3896/2/rs1043160/219746000/[c/t]/gtgtggccctggctgtggcatcggtggccgtaatacatcagtctttg gggctgtcctgca[c/t]ccctacacctgggccgcctgaccttggactgacctcccgttgcctcctggagccctgcat/c /C2orf24/chromosome 2 open reading frame 24/ 3897/8/rs7846408/52523096/[t/c]/caacacagcaacaaagactctggcaaacagcagttaacaggtttgctc aaggtcacatga[t/c]aagcaaatggaggagtggagatgtgagccaaggctttatggttccaaagtctacctccta/t/ PXDNL/peroxidasin homolog (Drosophila)-like/ 3898/15/rs4932305/88565223/[g/a]/gcctgctcctcattccctggagtgcccctgagcccatgtgtccaccc tcctgcagaacat[g/a]gagaacttcaccctggcaagggacgagaaggggaatgtcctcctggaagatggcaagggc/g /SEMA4B/"sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and 20 short cytoplasmic domain, (semaphorin) 4B"/ 3899/4/rs7678335/5503796/[g/a]/gcggtgtctggcacacaggagatgtgcggattattgtgcaaataagtaa atacacacaca[a/g]cgatgattccacaagacaggtagatgcaggtaaagctctgctgacttaggtttagaggag/g/S TK32B/serine/threonine kinase 32B 3900/20/rs157104/55697026/[t/g]/accccagagttagagtatcaggaagccacaaagaacggcaggcagcaa gggctgaatgac[t/g]accacatcatcatcctcagcacccagtggtcgacctcactctgccaggcagggaactttg/g/ TMEPAI/transmembrane/ 3901/1/rs12029239/206139249/[c/a]/tcgtttctggaagagaccaaaacatgggtgtgcatgtgtgcatgtg ctcatagatacaca[a/c]aatctcaggtcatgatatgggcatgcacttcaacacagaaaagggagtttggggagttaa/ a/CD34/CD34 molecule/ 30 3902/5/rs3910815/146091900/[t/c]/gaaaagtccttgatgctgactcattcattatcacaagaaaggaggag gcagctgaaatca[c/t]cactcatttattctgcttctaacttacggtgaaaggtcaaaggtaagtcactccacatag/c /PPP2R2B/"protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isofor m"/ 3903/13/rs12584534/94553551/[t/c]/gcctgggcgacagagcgagactccgtctcaaaaacaaaaaaacaga aaacaaaaacaaaa[c/t]ctgaagcttttcctagagaaccaagagcacttgcaaagggaattttcatggctctgatat/ t/ABCC4/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 4" 3904/13/rs1752056/38868475/[a/g]/attctgaggtactgggggttaggacctcaatatacctctgttttgga gatagggcgatgc[g/a]gtttagccaataacaccaggttaggatagttttcaaaattatggaggagctgaaccttgc/a /LHFP/lipoma HMGIC fusion partner/ 40 3905/7/rs6969900/21813982/[a/g]/tgtgtggaaggacgtaaaccttgccataaggtaattgcattaagcatt tgtggagttgac[a/g]ttcagcctgcaattacagctgagtaatttcatctttcagtcagagaagattcgctggggt/g/ DNAH11/"dynein, axonemal, heavy chain 11"/ 3906/8/rs13249456/2896758/[t/c]/gttttaatatacctgcaatgaaaatcttgctgtagaaatttagtgtgt atgtgagtggaa[c/t]tattcttctggtgggttttgcataacagactattattccataagactagagtttcagaaa/t/ CSMD1/CUB and Sushi multiple domains 1/ 3907/12/rs10877771/60652610/[g/t]/caaagtgagttgtgttttcttggccaaaccctgactgatgatatgc atggtatagaggaa[t/g]taggactgggtaacttaaggaggctagaaatggggaaaggactaagcagtaaataactgg/ t/FAM19A2/"family with sequence similarity 19 (chemokine (C-C motif)-like), memb er A2"/ 50 (279) JP 2010-88432 A 2010.4.22 3908/17/rs9754/31285944/[c/t]/accatgtcttttttctccgcagggtagaatggaggttgcactgttcaggc cggccactct[c/t]ctactggctgacaggatgccgcctgagatgaaacagggtgcgggtgcaccgtggagtcat/t/LY ZL6/lysozyme-like 6/ 3909/17/rs3202848/8017380/[a/g]/tagctatgaagttctgactgggataaccttgctgtttgtctattttgc agtcttgctatt[a/g]ctgtttgtctattttgcagtcttgctaaatttgtttgttcttgaaaattgtgatttggtt/g/ TMEM107/transmembrane protein 107/ 3910/13/rs9564009/62659967/[t/c]/catataacatcagggtaaaatgaaagacattaaacaacttccaggca tacaaataaacga[t/c]tgaaataaagatcttttctgacttttataaggtcaatatattctagaaaacaatgcaaca/c /LOC729287/hypothetical protein LOC729287/ 3911/8/rs4870844/124161424/[g/a]/ttgcaccataagtgttactattttgtccattcccttttcactgttgg 10 ttgttggggagaa[a/g]aaataatttttcctctacccttctagattctcaactggacccttgtaacaaaagatagat/a /WDR67/WD repeat domain 67/ 3912/6/rs3800270/151785755/[t/c]/ttggaaactgaggagggtagggtacaccttgataccatgggtagctc tgcagatagggcg[c/t]gactaagactttcctggcctccccttcactcctcaggactaagagtaaacctcagaaatc/c /RMND1/required for meiotic nuclear division 1 homolog (S. cerevisiae)/ 3913/4/rs11933482/7648612/[a/g]/ccctggccccatggggaatgggaacatgcctgacagctgctctttccc tttccccagcct[g/a]cattcctgccacggcaacccgcggtttctcattgagactgcatcctcacaaaccatggtt/g/ SORCS2/sortilin-related VPS10 domain containing receptor 2/ 3914/13/rs7990263/35359216/[a/c]/aactgccctaaatgttagcttggaatccaactggaaagacgaaatag ttctgcgttgctt[a/c]tatttttggcaaaatgagactctgtcttcatagataaatccagctacctacagttgtcag/a 20 /DCLK1/doublecortin-like kinase 1/ 3915/6/rs1147855/148886144/[t/c]/tctcaaggctaatttttaacattaaccttctgttccagcttataatg ccatgtacatttc[c/t]tccttcttgcaaaagcagtgattttattctagttcctttcccgtgactcagggcttcaca/c /SASH1/SAM and SH3 domain containing 1/ 3916/20/rs6044967/17652060/[g/a]/gcaaaggcaatgctgcagcccagttacttccacgaaggagttaagct gaagattgagccc[a/g]ttcacaaagaaagactgagtcgagagagctgccgggaaatcaagctgaagccttgctcaa/a /BANF2/barrier to autointegration factor 2/ 3917/12/rs4237913/94686419/[c/t]/caagccaaggagggtcagagagtgagaaagaacatggcacctgagag tgatccaagcagc[c/t]caacagatccagctagaggctacagctcaggaggcagggatgagacaagaggccaggggg/t /NTN4/netrin 4/ 30 3918/5/rs9326761/108497343/[g/a]/ttctccatttatgtgataattgttccctaaatccaaatttatgtaac aaaactatattct[a/g]tgtatttcccatgagtcaactagtttctctttagtgtctgccatttccagcattctttta/a /FER/fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) 3919/2/rs2584353/124875762/[g/t]/gactttcaataaattctatttgtacttacgttattgatggaggagat ttaatgcaaataa[g/t]tcacaggcaaggacatttgttcatcaaagtagaagaaggatgagaaaatggaatatagaa/t /CNTNAP5/contactin associated protein-like 5/ 3920/1/rs6703771/17849147/[t/c]/aaaaagccttggaaacagatgtttcccaagctagggactagcacaatt tgatatatagtt[c/t]gcattttttggatccttctggctggtgtgtgagagtgaattgcagataagaatggatacc/c/ ARHGEF10L/Rho guanine nucleotide exchange factor (GEF) 10-like/ 3921/11/rs5215/17365206/[c/t]/ccagtaggctgtggtcctcatcaagctggcgggccgtgcagagtggtgtg 40 ggcactttga[c/t]ggtgttgccaaacttggagtagtccacagagtaacgtccgtcctcctcagctacaatggg/t/KC NJ11/"potassium inwardly-rectifying channel, subfamily J, member 11"/ 3922/9/rs2360704/400312/[c/t]/ctcagttacaggcccccctcaagtaaccactattctgactcttattatta gaaattaata[c/t]tgcctgttgttgaatttcatagtcttttgctgaatgttgtgactgtgacatcctttagtg/t/DO CK8/dedicator of cytokinesis 8/ 3923/10/rs870552/133820578/[a/g]/gaagaaaatgtccttttctactgtgaacatttcctaccattggcatg atgaccatctctc[a/g]gagaacaagcctcagataagcatggggaccgcgcttttgcaaagatactatgtgtatccc/g /C10orf39/chromosome 10 open reading frame 39/ 3924/11/rs1238566/128120696/[g/a]/ttcctgacttgatgggcctgaggtcaccaagcatggctcagccgtg aatcacggaaaaga[a/g]gcggccattaagagctggaaaacggattcagggtctcccctgtccccatgccctgagagg/ 50 (280) JP 2010-88432 A 2010.4.22 a/FLI1/Friend leukemia virus integration 1/ 3925/3/rs7624495/104743744/[t/c]/ttagaagcctaaaaatcaattgaaggagaacaaattgtttgaagcat tctatctaatgca[c/t]tttatctgcagcattttttccccagatatcatactctgttagggttaatcacacaacaat/t /LOC644681/similar to synovial sarcoma/ 3926/9/rs10758574/4199925/[c/t]/accccaagttgagaaccactgctccaggccaagactgcaaagaggatc tgtgtacaaaca[c/t]aaaggagacaagacatcccatcccctcatccgtaatgttttccatcaatatcagtctatg/c/ GLIS3/GLIS family zinc finger 3/ 3927/15/rs4842882/83785187/[g/a]/gcttaaatagtgcaagtagatttcactgtagggactgatatagcagt tataagagcccac[g/a]gtttgaaagcaagagaaactctaaaaaaacaaaacaaaacaaactgatgtcattggtgtc/g /AKAP13/A kinase (PRKA) anchor protein 13/ 10 3928/15/rs1044246/88573204/[g/a]/ctgagccctttgtttaaaaaacaattccaaatgtgaaactagaatga gagggaagagata[a/g]catggcatgcagcacacacggctgctccagttcatggcctcccaggggtgctggggatgc/g /SEMA4B/"sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B"/ 3929/18/rs605144/8801004/[t/c]/cagtaaacggactaagacaggctgctgagtggtgtgctcagttaaactg gaagtttttgc[c/t]cacaagggactcactgggagagagctaacatcgaatctcgcctctgtaataaaggcaaat/t/K IAA0802/KIAA0802/ 3930/19/rs1997231/49812876/[a/g]/atttctaaataaggtggtgagaaaatgttgggtgaggggttgggtag gagtaaatggagc[a/g]aagcagatcccagaaccagaagacattagtagtatatggagagagacactcaacaggagc/g /LOC147710/hypothetical LOC147710/ 20 3931/3/rs2048806/55018110/[g/a]/cagttcatagtcttggtagaggagaatattctatttgtatttctgaac taagggaagaga[a/g]gcttattagaaattggctttttactgtggaatcaaactagatgatattaagattgaacaa/a/ CACNA2D3/"calcium channel, voltage-dependent, alpha 2"/delta subunit 3 3932/4/rs12645079/120413960/[c/t]/gagcaaaaggtcctggctcaaaaaaaaaaaaaaagacttgacaagg taattttataattc[t/c]tcttggaatggagtagcctagggtagtagaaagatcaggactttataaccagatagactt/ c/USP53/ubiquitin specific peptidase 53/ 3933/3/rs9867080/33595309/[a/g]/cagaatcaatagttatctgtgacttgaagataataggtgtctgaaata aagtaagccttt[a/g]aaatatcttggttccagaaatacatggaaactaaaggtgcaagttccagagaagttaaac/g/ CLASP2/cytoplasmic linker associated protein 2/ 3934/6/rs1047953/22294843/[g/a]/actgtgtcagtccaaagatacctgaagaattgtcctgtgctaacagca 30 gaaaagtttcca[g/a]ttgatttaaaatcaagtgatttgcaatgtagttacaaacaaaattattaagtgcctattt/g/ FLJ22536/hypothetical locus LOC401237/ 3935/10/rs17497526/71250126/[c/t]/cccaaccctgtgatggcagcttgctcagtgctgctgctgagtgggt gacaactccgatgg[t/c]tacaacctttagccaaaatgctgccaactcctctggtcttggcttgtcagtcatttagcc/ c/COL13A1/"collagen, type XIII, alpha 1"/ 3936/17/rs3935866/1817115/[a/g]/gggcctgcagaggggcctggctcctgggttgccacttgtgccacctcc ctgcccacttta[a/g]cctcttctgtttcctgcgtggcctctgaaatcatttgaattgagacctcggggtcaggag/g/ RTN4RL1/reticulon 4 receptor-like 1/ 3937/13/rs383353/112527549/[a/g]/tgtgagcagccctctctctcctgcttgtggcactttaccccgtcttg gttcttacctttg[a/g]cctctagaagtacgtgccagggaccatggcatggacgcaagtgcagaggacccaccgtgg/g 40 /ATP11A/"ATPase, class VI, type 11A"/ 3938/7/rs13232623/101284169/[a/g]/gagtttatacctttctgttccaaagcaaacaggatcgtctgccatg ttgaactggatgtc[a/g]gacaattctgaaatgtgtgcatggggcaaggctgtgtgtgatgataccagtttcatagga/ g/CUX1/cut-like homeobox 1/ 3939/2/rs3791289/134827909/[c/t]/gaaatatggaaatgaatagagaaataaagcagtttgatacctttatc ctattgagatgtg[c/t]ctgagctggaaaatttgcaacaacaaaaaaaaaaaatagttcctacactctgttttccag/c /MGAT5/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransfe rase"/ 3940/10/rs12415091/122646609/[t/g]/tcaagtaaggaattgaaaaaccaaggaggacctgacataagaggc ttctcctgtcaaact[g/t]ggggtagtctgagcatcacgaaaactaatggtggtattgatgtaagtgcagaataccaaa 50 (281) JP 2010-88432 A 2010.4.22 /t/BRWD2/bromodomain and WD repeat domain containing 2/ 3941/10/rs1866518/122651094/[g/a]/gtaacagattctagattgcaaaaatgtgttacgctttccccaagaa ctccttgtagaccc[a/g]tattttttcctttcttattcccagtacattctgttaaatgcccttggctctagggagcac/ g/BRWD2/bromodomain and WD repeat domain containing 2/ 3942/2/rs4852054/239944882/[g/a]/tagaattccaaggcaaggatgagctttcactgctccatcttcccagt gactcagtaatct[g/a]cttccgttcgtgtggactcacagatagttacgttatccgctgtgttattagtcccatact/a /HDAC4/histone deacetylase 4/ 3943/4/rs7686660/144222609/[t/g]/caggggaacatgataatctaattggatagaactggatcatgtgcaca gccctgagacaag[t/g]agctagaggagtactatgattggaaactctaccagaatatcacaatatgaattaaaaaat/g /LOC729675/hypothetical protein LOC729675/ 10 3944/7/rs6466375/110611661/[t/c]/tgccaatttccatctaaaatgacaccctgaaaggtatcatcatttac aaaaattatgttg[t/c]acagaatgaattgtgtgtagtattccaaagtacatatatattgataatttgaagtcagtg/c /IMMP2L/IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 3945/18/rs10503140/64857835/[c/t]/tgattgtactattattaattatatgtgtcagtttggttaaattacc taaactttcttata[t/c]cctcttcaatattttgatgtgctataatgtctcaactggccagaaaatgcatgattatat/ c/CCDC102B/coiled-coil domain containing 102B 3946/17/rs7225151/5077771/[a/g]/cactgaagcagagtgaagcctgtgctccacattgcttcatggccaaga cctcagggacaa[g/a]tggacacaccaggcagtgggagtggatatggcaaagccaaacccagatctcttctcaaaa/g/ C17orf87/chromosome 17 open reading frame 87 3947/7/rs2107145/110570697/[t/g]/tctttcacggggaacatctcagtgcttttaggataacacctgttgtt 20 atggatttatttt[t/g]ggaatttttgacctcaagtgtgaatgctgcatagccttgtgtcatgagtgtttacctcgc/g /IMMP2L/IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 3948/6/rs794120/164629961/[c/t]/caagtaaggcaaaataagctgtaacagaagctcacagtacatgccaca cacatccaggag[c/t]gtgtagaatgaggaaccaaaacaagaaacaagaaatggctccactcctgtgacacaaaga/t/ LOC728275/hypothetical protein LOC728275 3949/5/rs1444649/124667367/[c/t]/atgaccagactcgcttagacccaatgatgatgaaggaaatagaacac agaaatatgtaag[c/t]aggtacatcaagaacttctttttatggtattacgtcctcctctagagtagtaaacccaca/t /LOC644659/similar to High mobility group protein 1-like 10 (HMG-1L10) 3950/13/rs8002885/72296050/[a/g]/tctaagaagtcttgatctcttagtggggaatgctatttagaaattta ggatttgggtgct[a/g]tggtcatggctacattggtcattatttctaggccctttgagtaggcagagaaagtagagg/g 30 /PIBF1/progesterone immunomodulatory binding factor 1 3951/13/rs2031295/72271214/[c/t]/aaacattaaatgacctggtcatggtcacacagtaaatgagagtgtca aaatatcacctaa[c/t]gttctaatcctaacctgctagaaagtaaactctagaagggcaggcattgcctctcttggg/t /PIBF1/progesterone immunomodulatory binding factor 1 3952/2/rs13023991/158607190/[c/a]/ctagaaggggaagttgtctgatgtgtgtcatgatcacagatgccac ccttcccccatctt[a/c]aaacaagctccaccttcccatcctgttggattagcactgattaagggttgagaacaaaca/ a/UPP2/uridine phosphorylase 2 3953/6/rs2571584/129845178/[g/a]/aaaaagagtatcaattttgcaaggacataaactttagtatctatatc ccctgtccatttg[a/g]ttctgttaaaagcaatccctcaactgcccagatttaagcatcatacctcttattgccttg/a /LAMA2/"laminin, alpha 2" 40 3954/18/rs3786248/45372217/[g/a]/agatagactttgcctccaggaaatctgagtcctctccctggctgcac cactaactagtat[a/g]taagtctaggcatgtggctgaacctcactaagcctcagttttgtaaaatagggataataa/a /LIPG/"lipase, endothelial" 3955/2/rs1505359/212920079/[t/c]/agagtcatatcagataggcctaagtgctaacattgtaagatacagtg ttgggaaaaatgc[c/t]ttggcaatctttccaaaacacttgactctctcctcatggaaataataacacatttcattt/t /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 3956/12/rs6539496/79186733/[c/t]/ctttagcaatcagtgtgtctcattttctcttccctggaccttcctct ctggtgttcttgc[c/t]tctagtttttcccctctttcattctgccgaggtgtcctgtctttttggatttaacatgat/c /C12orf64/chromosome 12 open reading frame 64 3957/12/rs2400697/79189125/[g/t]/caggacaggggctccatattcttccagaaagcttttgggctcttaga 50 (282) JP 2010-88432 A 2010.4.22 gatcaaataaatt[g/t]cctcaagtggggccaaagggataaaatcccgtgggttcctctgtgagaaggctagccacc/g /C12orf64/chromosome 12 open reading frame 64 3958/12/rs4483657/79189528/[a/g]/tagaataaacctattttatgaattttggtgttcatatctcccatgcc atgacaaaaagtt[g/a]aggacattttgtctgtgcttatatctgaagttcacatctgcccagagggaaaagagtatt/a /C12orf64/chromosome 12 open reading frame 64 3959/9/rs1998513/8498015/[g/t]/cttaccagcccacattttgaagaagaggtgtaagaaaggaaaaacaaaa caaaacaaaac[g/t]ctatcacttacaaataatgacttctaatctctaaactatgttaaattatttaaagaacta/g/P TPRD/"protein tyrosine phosphatase, receptor type, D" 3960/4/rs6816078/147055240/[c/a]/tttccctgcccaccttctggtacacacagaagtcaacaatagagagc aaaaaaacaacaa[c/a]aattaacaaaaactgcaatcaaccaacaagctaaggtaattccaagggccaggatacccc/c 10 /LOC152485/hypothetical protein LOC152485/ 3961/17/rs11078741/1808311/[a/g]/taaaaccaaagcgaagtgatttgtccaaaatggtggagtcaagattc aaacaagattgcc[g/a]tggcatccgaccgtgggaggagacatctctctccttagaggccgctgctgcacagagacc/g /RTN4RL1/reticulon 4 receptor-like 1/ 3962/4/rs6533371/109766466/[c/t]/cagggtggtttgggaggaatggcccttctatttgaaactttaatatc cctttgatcctta[c/t]tatggtatctcctttacgtcagcaagtttcataggatagaaaccttggtattctagttcc/t /RPL34/ribosomal protein L34/ 3963/8/rs609020/12993322/[c/t]/cttgaataataccttgaagaaaaatatataaatatttgaactgttcccc tcctgtatttc[c/t]tctacctagggtaatgcaaagaaaacaaagtttgggcaaaccagatcagaaagatttgaa/t/D LC1/deleted in liver cancer 1/ 20 3964/4/rs17038733/109380418/[a/g]/acgttagatatgtttttccaaattttaattatttattttcctggct tagtggaactattc[g/a]ttaaattaactcattaccatttgtattagtccattttcacactgctgataaagacgtacc/ a/LOC644993/hypothetical LOC644993/ 3965/1/rs1276303/68033366/[c/t]/gtttcaatgtttttcctagaacctagtctacaagtgtagagttaggat tcaaatctagga[c/t]gtgtgaattcaaaggccttgcgctttttactatcccatgcagcttcaaacagtaatctct/c/ GNG12/"guanine nucleotide binding protein (G protein), gamma 12"/ 3966/17/rs1047268/30701608/[t/c]/tctttaaaagtctaatttcgactggttgtatctctttatgatttatt gccccactaacaa[c/t]atttgaaacaatataatattttaaaatgtataaataattatgaatttttgtttagaacaa/c /SLFN11/schlafen family member 11/ 3967/22/rs7291756/28656102/[g/a]/aattcctttcatactatttgatttccagataattttttaaagcctta 30 ggagtgtgtttgt[a/g]taatatttttgcttttgaaagtcaattaaggtaaattgtctacaacaaaattcacttcgt/a /MTMR3/myotubularin related protein 3/ 3968/20/rs8118127/8142378/[c/a]/ggaaatggtggtggtggtggtggtgtgtgtgtgtgtgtcttcataaga gtaacatgatta[a/c]gtttgcattatcacaaattgtcatgaaatataaaaagaatgcttagaatttaaaaattag/c/ PLCB1/"phospholipase C, beta 1 (phosphoinositide-specific)"/ 3969/12/rs10861233/103482436/[a/g]/ttgagagaattaaatgagatagtgcctctgaagctggaaccacag tgctcagggtttagc[g/a]ggtctgcaaacaatgtaactgttggtgttatgatattattcctgtggcccctcactgcaa /a/CHST11/carbohydrate (chondroitin 4) sulfotransferase 11/ 3970/19/rs1206032/47563136/[t/c]/ccttggttaggggctgggtagcaactcacaagccatatttgtatgtc aggaccccaaaaa[c/t]gtgcacaatgagattcaggctcttgggaacttacctcagtgtataaggcactttatttat/t 40 /MEGF8/multiple EGF-like-domains 8/ 3971/3/rs4328759/33577911/[c/t]/cactgagtaaatgagaagatgactacaatgaccttaaagtataaaatt tatctggcataa[c/t]agactaattagagaatcctcagatttctcaaaatgacaattgtcacaaataatttggtat/t/ CLASP2/cytoplasmic linker associated protein 2/ 3972/10/rs12571023/90685964/[t/g]/aattactcccatattacatatgaggaaacagaggctgagaaagttt aagtaactggccca[g/t]gtaacaccggttatatcagtgtcagatctgatattcaaacctgggttctcccaggtggtt/ t/ACTA2/"actin, alpha 2, smooth muscle, aorta"/ 3973/3/rs6773558/151861548/[c/t]/acagaaaacttttttacagattaagtcaatgatggctctaataagaa agatttatccccc[t/c]gcccccaccttgtttccagcggggttggaataagaaagatttcatcggcaggataatttt/t /C3orf44/chromosome 3 open reading frame 44/ 50 (283) JP 2010-88432 A 2010.4.22 3974/18/rs500903/30947301/[a/g]/aataggaatctcctggcagcgtctgtagaaaagcccaagggcttcttc ctaggaagagcc[a/g]tacatttttcattgccatcctaatttctttgcttactgaggtagcatttttgacagatga/g/ MAPRE2/"microtubule-associated protein, RP"/"EB family, member 2" 3975/17/rs2289681/40344614/[t/c]/ggccgcgctcaccgtgccgcgcagagactccaggtcgcaggtcaagg actgcaactggcg[c/t]cggtagtcgttggcttcgtgcttggcctggcggagcagctccgcgttgcgggcagcagcg/c /GFAP/glial fibrillary acidic protein/ 3976/17/rs1126642/40344589/[a/g]/ctccgccaggccaagcacgaagccaacgactaccggcgccagttgca gtccttgacctgc[a/g]acctggagtctctgcgcggcacggtgagcgcggccagggcaggacggggacgggcggagc/g /GFAP/glial fibrillary acidic protein/ 3977/17/rs2289674/40308935/[g/a]/agcatcagttggaggcagcttcagctccaggatcagccggtcaatct 10 tgttgatgcacac[a/g]gtgactgccagcctctcctgcaccgcatgcttgatcagccgctctgtgttcagcatcacc/a /EFTUD2/elongation factor Tu GTP binding domain containing 2/ 3978/3/rs11713787/74515167/[g/a]/taaatgggttttctttctccctattatatttttcaacactccaccta tctagttaccagc[a/g]caccattttaagtaatagatgcgtgttgaatgggtcaataaaggtaaagatgtaagaatg/a /CNTN3/contactin 3 (plasmacytoma associated)/ 3979/2/rs717827/40351005/[g/t]/ctgctggcacctcaatgttagcctagtaagacctgtgtcagacttctga catacaaacta[t/g]aagatgataaatttgcattgttttgcaccaattgtgaaaatttgttacagcagcattaga/t/S LC8A1/solute carrier family 8 (sodium/calcium exchanger) 3980/12/rs3847810/93103156/[g/a]/ttgtgaggaaaacaaggactatcctgagctggatccttcagttccaa gttgacttcatgg[a/g]ggataaccacgcccttccatttcatagtccccaacactgctgacagatgcagctggcagc/g 20 /PLXNC1/plexin C1/ 3981/4/rs11737767/154099328/[t/c]/tatggtcttatacaacttccctctgcccctgcccatatatagtgaa ttgttcaactctag[c/t]tcagaagggattagaattcatcgtgtaggtttctcagcacagaagccagggactgatttg/ t/FHDC1/FH2 domain containing 1/ 3982/8/rs10503501/14473514/[a/g]/tttctgactgcattttacaaaattaattatttgtaaaaatgcatttt ctccagaggcttc[g/a]agctctatattccaagctataatatttaattctgtcttctgcctaatgatctgaaaaggc/g /SGCZ/sarcoglycan zeta/ 3983/7/rs4730479/110567707/[a/g]/aatgacctggctaatatgaacctttggacaagatcatgtcttcctga gcccaggtgcatc[a/g]atactggatattttctgcatgcccattcaatctacagggttctgaaacctaaataaaatt/g /IMMP2L/IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)/ 30 3984/3/rs4234692/61879985/[a/g]/cggctcatctcctgcttcattttcggtgctgcgttgaggttggagata cagatgtggttg[g/a]tcatgcacagttaagtaggggagtgttttgggtctctgcaaagtaaggatgtggtagaaa/a/ PTPRG/"protein tyrosine phosphatase, receptor type, G"/ 3985/13/rs8002545/72242849/[c/t]/tttaagcacgtgcccgcagctggggacttttttagactatgtttata tctcaggtactta[c/t]atgtatatgttttttctattttaggttaagtaaatatacatataattatacataacatct/t /DIS3/DIS3 mitotic control homolog (S. cerevisiae)/ 3986/2/rs723713/51371279/[t/g]/tccttcccttataaatttatacagatgctgacctagcaatagattagca gaatgtttatt[t/g]aggtcttgtccatgtactatgtggattcaaattcctgaagagaattgttaaaatgcaaat/t/L OC730100/hypothetical protein LOC730100/ 3987/15/rs7176074/71620653/[t/g]/tccatagaattcagggggtccatgaacttccatggattttcactgac 40 ctctaattgaaat[g/t]tatcatttccttccactatgaatgtaaggccagcagaccacagtagttttagaccttctc/t /LOC283677/hypothetical LOC283677/ 3988/17/rs1002327/62305077/[g/a]/aatcagatcctagtgacttcaaactccagatttaagcacagaccaat gccacgcagtctg[a/g]ggcagaagaagccagagttggatgtcattcacatggcagactcaacaccttgaggtgtct/a /CACNG5/"calcium channel, voltage-dependent, gamma subunit 5"/ 3989/4/rs13116507/144258888/[g/a]/agatattgctgagaatgtgaataacataaggacagaaaattaacat tagatttggcaaaa[g/a]ggaggtagtggttgacatcaataaaagcagtttcaatgaagtagtggagaaataaatctc/ a/LOC729675/hypothetical protein LOC729675/ 3990/4/rs4270544/144263788/[t/c]/ctcccaatgggttgactgaatgatctaccagcatgtgattacatata atattgcatcaga[t/c]taaaggatacacttttcagcaaagaaggtgtgagtacaagtatatgacaatgagatccac/c 50 (284) JP 2010-88432 A 2010.4.22 /LOC729675/hypothetical protein LOC729675/ 3991/4/rs11100775/144293362/[g/a]/tttccttcttaatttcttcattggcccactggtcattcagaagtat attgttcaatttcc[a/g]tgtatatatatagtttcctaaattcttcctgttactgatttctatttttcttcttttgtg/ a/LOC729675/hypothetical protein LOC729675/ 3992/12/rs10846915/124605386/[c/t]/taaatgttattttcaccatttaattttactttgtatttctttgct gcactttcctctttg[t/c]tggcgagtttcatcttttgattatcagtttttcagtgtgtgtcaggtggttttatcactg /t/TMEM132B/transmembrane protein 132B 3993/9/rs10816027/8972620/[c/a]/tgaaaatatgacctaaagggaaaggacagaaaaaaaaataaaaaactc cacaatcatcat[a/c]ttataaatttgtttttataacttctgggataaagggtttctaaaatacttctatctcacc/c/ PTPRD/"protein tyrosine phosphatase, receptor type, D" 10 3994/8/rs1519369/139463091/[c/t]/agaaggaatgaaagactaaacaaatgcaagagaaaatgcacatatga atgactgaataaa[c/t]ccattactctcctttctgatcaaagttttctggggcacttggaatcagctcctacttagg/t /FAM135B/"family with sequence similarity 135, member B" 3995/9/rs9696174/72722349/[c/t]/acagtgttaagttgttatatcaacttaaaataatggcttatactatag attcacaagtct[t/c]atggtagcctcaaatccaaaacagagtaaatacacaaaaataaaaagcaagaaattaaat/t/ TRPM3/"transient receptor potential cation channel, subfamily M, member 3" 3996/7/rs41269/105407033/[a/g]/gcccagcatagagaccagttcatctacacttacgtggctcctaggttgc ctctgttcacc[a/g]gtagacacaagaatacctctttttcccccctcgacaatcttccataccctctcctttcac/g/F LJ23834/hypothetical protein FLJ23834 3997/2/rs881029/241051687/[g/a]/caccacccagatctggcccgggtcagggcatccctgatcaggtccctg 20 ggtccaagctct[a/g]agctagggaccacccgccccccaggacccccagtcgtgcactccccaagacagttccagg/a/ GPC1/glypican 1 3998/9/rs3853275/30433903/[t/c]/gaagacactaggctaagcttataggtaaacaggacaaagcatctgaca ctaaagtcatta[c/t]aatatattgggtcactcagatacataaatgacataaagtggtgagtggtaaggtatagat/t/ LOC401497/similar to PRO2738 3999/7/rs2713174/82913893/[c/t]/aaaagcagtggaaggtatagattcacacagcagatgctgcttagacac aattgttaccaa[c/t]gttaaactctctacgtgacccttcatagttttacaaagtgcatcaatatagtatgtaatt/c/ SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E" 30 4000/13/rs2274554/78838530/[c/t]/tactatggtttggagtgaccctgtgaattaagtatatcactggtaaa acccagctgcctg[c/t]aggccttcatagcttaaggcaaacctgctttggaatgtattaaaaggatattttaccctg/t /RBM26/RNA binding motif protein 26 4001/13/rs2351871/90970278/[g/a]/aaaataagatttagaaaaattggaggtctaggagcacaataaataga aattgctaatgaa[a/g]gatatgttgacttactggggatggatggaggcaagctagagatttgatcctgcaatccag/g /GPC5/glypican 5 4002/13/rs4771841/91013581/[g/t]/cacaaacatatgcacctgcacagatatggaccgcctgctaattaatg ttcaaacatataa[g/t]aaaaaataatatcgggaattatgatttgctgttccgtgtagtagcaattaaaaaaaattc/g /GPC5/glypican 5 4003/1/rs1288516/53520874/[t/c]/ttcagtcagtatgagctgaggctcaggaacctgcactttgagtagctc 40 cctcacccccca[c/t]cctttgatgagaggaccccagcaaagcactggtcagcttcagcttcctgtgttccagtgg/t/ LRP8/low density lipoprotein receptor-related protein 8 4004/16/rs11643269/75935068/[g/a]/aggcctcaagctggcctgatttctgagtctagtaacaaccactaca ctaggcctggattt[g/a]ccactgatggatattggaaggctctcaaattctccaggcctcagttttctagtctataaa/ a/ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 4005/10/rs12765810/20256180/[a/g]/cagaaaaatcaaccccaccttgtgaaagtaacacacaagacactga actgcagtaaaaca[g/a]ggtaggttatgagtcacgggcattgggagcacaggagagggagtgacaacacctaggaga/ g/PLXDC2/plexin domain containing 2 4006/5/rs9885024/124711331/[a/g]/tgctaaagcttttaacaaatcatttcatagcacaaacacttcttttc acaagaaggaaat[a/g]gaggcaatgggttcttgtctaagacgcactgttttcaacagaaataaagcagacacttaa/g 50 (285) JP 2010-88432 A 2010.4.22 /LOC644659/similar to High mobility group protein 1-like 10 (HMG-1L10) 4007/22/rs41156/28734653/[c/t]/gctggaaattgaaagcagctgtaccaaggtgaaatttgaatgtgtgaac gcattgttctg[t/c]ggagttcttttcaaagagatttcaaagccacaagttagataaggcccaagaagtaaagcc/t/M TMR3/myotubularin related protein 3 4008/14/rs3742569/54888459/[c/t]/atgctgctgggggtgacagtgcatctgaggaaaaaagtgggtctgct gagccatttgtac[c/t]gccagcctcttctgtggaaagtacattaccagtgcttgaggcatccagttggaagaagca/t /FBXO34/F-box protein 34// 4009/5/rs400277/108703636/[g/a]/agtaaacagcacgtgctaatgtgtattatttgaggagtattgtctgca tagagataatgt[a/g]tgtctcaagtctcatgagacttcctggtattctggattgaggtataatgctggattctga/a/ PJA2/praja 2// 10 4010/13/rs7321384/112366695/[c/a]/aaaacaaaaggtgtgtccttgaatgtgctgccggagcgtccagtgt ctcatagggcccca[c/a]gtgtgggacccaccaaagagaaagtgataggatatctatgagtcgatctcgtcaatgtcc/ c/FLJ26443/FLJ26443 protein// 4011/2/rs2122715/46699353/[c/t]/gttagaacaagatagtaaaaggaaaattaaactttattatttaataag tgcattacattg[t/c]gcctaaggttcacaatggtatcgactatcaatggtattaccgtaggagcctgttaatgct/t/ CRIPT/cysteine-rich PDZ-binding protein// 4012/2/rs1434094/178944294/[t/c]/acatgtttctgtgtatcaatgggatgttcattcccagaggattcact gtacctttgtcaa[c/t]agggtccttgtagggatgccatgcttatgtaaagctgttctcttcttgtaataaatgcag/c /OSBPL6/oxysterol binding protein-like 6// 4013/2/rs6706354/178947314/[a/g]/gtgtcttctatgattcctatttcagggtaacaaaagagtttatgaca 20 gagctgtttatag[a/g]aggagactagctaataaatatagaaagaatgagagaattaggaaagcaccgttcatgcgc/g /OSBPL6/oxysterol binding protein-like 6// 4014/2/rs12468466/178949170/[g/a]/caagagagagtcagctcaggatctgcataaccagctacctgttaga cactgacacctggt[a/g]ctcacagaacctctaattcagcacgtcccaaaagagttcatcaacaagccccaccactcc/ a/OSBPL6/oxysterol binding protein-like 6// 4015/20/rs1012646/19183890/[t/c]/caggagatgtatgtattgttcctctgccaagagtccccaggggagtt gagtggcttatca[c/t]ggtgacccatcagtttaactcttgctgcctgtcagtggtggctgctgttgagaattccct/c /SLC24A3/solute carrier family 24 (sodium/potassium/"calcium exchanger), member 3" 4016/20/rs708920/8327730/[a/g]/cctccaagatgctccaagatctaaatggaaaatcacgaagtcatactag 30 aaaaaaaaaaa[g/a]aagctataggtgaattttctttataaactaggcatgaataaagacttactaactgtgact/a/P LCB1/"phospholipase C, beta 1 (phosphoinositide-specific)"// 4017/2/rs1385776/140995660/[a/g]/gaatgatactaccacaaaagaacacataagcacacagcccatgaacc ctacaaagcaact[a/g]cacaaatgacactaaaaatcacctagctaacaacactacaacaagaataaaatctcacat/g /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)// 4018/3/rs3805005/4771424/[c/a]/ctctcctttgctttagagtacctttttaataagcctcatattggcttga agagccaccag[a/c]acaccttcttgccctcttggaggattaccaaggagcttcctaccacagtccccttccact/a/I TPR1/"inositol 1,4,5-triphosphate receptor, type 1"// 4019/17/rs12452184/77274831/[t/c]/ctgcgtggcatttgccccccccccccccgcctttaatctagagtgt tccccagtcagctt[c/t]tgtgttttgtgacatctactgtcccaagagcactggcctgtcattcggcagaccgtcctc/ 40 c/HGS/hepatocyte growth factor-regulated tyrosine kinase substrate// 4020/15/rs1394125/73946038/[a/g]/gaatgttagatctctatatcttcaatgtcccttaactgttctcttac ttacatctcttct[a/g]ttttctcccccatctcctttttttctctgttctaaggaaatgtcactgtttgtttttctt/g /UBE2Q2/ubiquitin-conjugating enzyme E2Q (putative) 2// 4021/2/rs4852808/71665963/[c/t]/cagtagccctgtgtgggtgcttgtgaggctatgcgtgttagaatgcaa ttttcaacaggt[c/t]gggcagggatggcctctctgggcaggtgccactggccccgtgagcagcagtagccatttc/c/ DYSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)"// 4022/14/rs7140154/104234577/[t/c]/acaggggagggggctgtcccaggcagactcagaacatgtcacagcg ggggcctccaggcc[c/t]attggtgctggccgagggcataggagctcccacactgtgctgtggaaggccctcctcgcc/ c/INF2/inverted formin// 50 (286) JP 2010-88432 A 2010.4.22 4023/3/rs1511650/104830900/[a/g]/ctcagctctcgcaatcaaccagacctttgccaatagggaatggagga ggtcccaaaaaga[g/a]atcatcagtgtggtagtattggcaaggggcttgtgctcaggagccctgtgtggaatgtac/a /LOC644681/similar to synovial sarcoma// 4024/14/rs10483429/32702906/[t/c]/ggcttgaactgacagtgtaaagaaaaaagtgagagaaaattaccat tgtactttaaattt[c/t]tctgattgaattgactgattatactgtcagaggagcattgggaagctggcagggttatgg/ t/NPAS3/neuronal PAS domain protein 3 4025/17/rs2242374/8641841/[a/g]/ctgaatggggaggacggaccaccagctccagaggaaagagtagtacag cagctgcccagc[g/a]aggcagctcagccccagccccaccaggcccgtcctggacagtttcctaagcaatgtagct/g/ FLJ35773/hypothetical protein FLJ35773 4026/16/rs2098421/48197316/[a/g]/aaggagcagatgtgctaatgacaaaactttccaaactgaaaacacaa 10 ggagcagattccc[a/g]ggaaaggtgtttccccaacctctacctggtgatgggacgaatgagaaaaacactagccaa/g /ZNF423/zinc finger protein 423 4027/1/rs1361493/70004123/[t/c]/cttctcttgactatttttcagacattctatctagactcctaaccatca tagttactttct[c/t]ctgcacagattgcagttgttagcttggttttagatattgcattatcaaataaaaatattt/c/ LRRC7/leucine rich repeat containing 7 4028/12/rs12816393/29663326/[t/c]/gcatacaaatcaggggaaaaaaaaactaaagctgttagtgatgtct gataacttcttttt[c/t]cattataccactatctaagactcactaataaactcagtgagtcttccaactggggggtaa/ t/TMTC1/transmembrane and tetratricopeptide repeat containing 1 4029/8/rs908843/139451045/[t/c]/agaatttcaatctggcaaacatggaaaggcctggctcacaaaatgtgc caaaaacccatt[c/t]cccaatgaagagccatggaggtgcaccctggccctgcccaacacacccgagccagtcaag/c/ 20 FAM135B/"family with sequence similarity 135, member B" 4030/15/rs8024968/25957284/[t/c]/tatgcacacattttcaggagatagagtcacagaacagggagagtaca gattcacagactt[c/t]tcaggaaagagattatgggtaaagatagaccacagtccatctaaggcaccaaggtgaagt/c /OCA2/oculocutaneous albinism II 4031/20/rs6075340/1842335/[g/a]/ctctgtctacctggttctctccttctcccctattctagctcgctctct cactctgcgtct[g/a]tctctcaggcatgtgtttctctgaggtctttatgatcatgatctttcttttttttgtttc/a/ SIRPA/signal-regulatory protein alpha 4032/12/rs751363/69300126/[t/c]/tagagtcatgagagctgcaattgtagaaactgtcttttgaaagagcat agcttttacaca[c/t]tagcttaccaggacatagttaaaactttgcttaagcttcaagaaaaaaactggaacatga/t/ PTPRB/"protein tyrosine phosphatase, receptor type, B" 30 4033/18/rs2241508/70337384/[c/t]/aatacaggagggcaggtcacggggccatcacccccacctgcttctct tggcagctgcaca[c/t]ggggggaaggggaaggggcgagagggacgctgtgcaggagacgccaacctgggccgcacc/t /CNDP2/CNDP dipeptidase 2 (metallopeptidase M20 family) 4034/6/rs7739802/162154323/[t/c]/atcatcctggttcagcatcccaggtgcgcacctgagcatgtgagtcc ccctttgcccaac[c/t]tccagtctcaggcgcctcacccaccacaggaggggatgtccccagcctcaccgggctgcg/t /PARK2/"Parkinson disease (autosomal recessive, juvenile) 2, parkin" 4035/2/rs3731900/219755219/[a/c]/tgcggctctcatcccccctccactttgtgaacacgcacttcaatggg gcagggtcccccc[a/c]agatggagtgaaatgctcccctggaggaccagtggagacactgagccccgagacagtgag/a /FAM134A/"family with sequence similarity 134, member A" 4036/12/rs1869892/60590973/[t/g]/acttcttatttttgccagtcctaaaaacaaagaaacagtcaaacatc 40 tgatctttgaaat[g/t]aatgcctcctaaaatagagttgtccaaatcattggcagtgttagagctttgaagaaacac/g /FAM19A2/"family with sequence similarity 19 (chemokine (C-C motif)-like), membe r A2" 4037/11/rs660994/102616867/[g/t]/aagctgatcatgatcagacagactccaggttactcctgccattttat atgcatcaccttt[t/g]cccatatttatttttctttagctacaccggagtactgtaagttttccaaatactccaaac/t /DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1" 4038/19/rs2853332/40438546/[g/a]/cacgcctggcactctctgctgtccctgattcgttttctccatacagc ttatctttgtctg[a/g]tatgtgacatagttaacattttatatttgtctttctttcctagttagaatctgaactcta/g /LSR/lipolysis stimulated lipoprotein receptor 4039/17/rs6505476/30835146/[g/a]/ggttacatcaagagaattcatatgcaaatcatggtggtgacatacag 50 (287) JP 2010-88432 A 2010.4.22 aggaaaaagaacc[g/a]tctattccatataacacttaacaatttacagggaccagagtagatgttcaataaatgaca/a /SLFN12L/schlafen family member 12-like 4040/9/rs544456/3899709/[g/a]/ataagatcatgaaaaatcagtgtcagtatggacacaacaaaactaatgat tatttagtaa[g/a]aaatgatgatttatggaaattgttcaaagaaacatagaatttcagagcaaaaaggaacta/a/GL IS3/GLIS family zinc finger 3/ 4041/17/rs741141/61978116/[a/g]/tcgccatagggcagctcgcagcatggtagctggcttccatcagagtga gtaagagagggc[g/a]agccagacgaaatcagtcttataacctaatccaggagtgacaccccatcacttttgctat/g/ PRKCA/"protein kinase C, alpha"/ 4042/8/rs1376759/63553374/[a/g]/taatggttaaaagcatgcatagattctggacctgtgtcaccttggttt aaatactggagc[g/a]actactaactagctggatacccggctctactagttaccagttgattaactatgtctcagt/g/ 10 NKAIN3/Na+/K+ transporting ATPase interacting 3 4043/19/rs2075762/18850859/[t/c]/gcacatggctgtcagcagggcagtggcgtgggggctttcttctcact ggcacctcccctc[c/t]cctctcgcagtacatcgtggcgtttgcagccaaggtgttgacaggccaggtgcacgagct/c /LASS1/"LAG1 homolog, ceramide synthase 1"/ 4044/4/rs7690190/16128817/[a/c]/aaatgattgtctcctgcatgcaaaatgctttgcacaatgcatatgtat gtcctggccagg[a/c]aggaagctcttagttcagtcccaggattcctgccttttcatattaacagaggacctaaca/a/ LDB2/LIM domain binding 2/ 4045/7/rs10486759/50781046/[t/c]/catctttttacctaaagaaaactttttaaaggcctcaaaaagttaat cactctttctaaa[c/t]gctaaagtagttaatcacactttctagatgctaaagtaaactctctggctaaattaggaa/c /GRB10/growth factor receptor-bound protein 10/ 20 4046/4/rs11737182/90117499/[t/c]/tctaataaccaagatgcctactaagtaacgaacaggtaggtagcaca tacagagtggata[t/c]gatgtgcaaagagatgaagccatagaaagtgaaactgcaaataaagggataccactgtct/t /FAM13A1/"family with sequence similarity 13, member A1"/ 4047/3/rs9310563/18410222/[t/c]/cacacttactccatggcctgttttataaatagttttactgaaatacta ccatacccagtg[c/t]cattcatttatagtctatggctgctttattactctacagtgtgaccgagatttaagtgct/c/ SATB1/SATB homeobox 1/ 4048/5/rs246103/108727773/[a/g]/tatttaagggatttaacctccctccctgcgggcgaatacccagttgtc ccagtacatttt[a/g]ttgatgagtccttttttgtttttgttttttgagacacagtctcgctttgttgcccaggct/g/ PJA2/praja 2/ 4049/5/rs1045706/108742197/[g/a]/gacagacagaacattcacctgaagatgcagcctgtggtccagggcat 30 atttgtagtgaac[a/g]aaataccaatgatagggaaaagaaccatggaagttctcctgaacaggtagtgaggccaaa/a /PJA2/praja 2/ 4050/9/rs2593681/114374109/[g/t]/ataaataagtctaaatttctagagtatgaaggaaatgtaagatcacg tagtcctggcatt[g/t]taggcttagagataattagtgccttgtctgagaccacaggagcagttccaggcttgggat/t /KIAA1958/KIAA1958/ 4051/18/rs664209/4329053/[t/c]/gatggggacaaaatagtcatttaacacaccgcagatcaatgatttcatt tagaatatgta[c/t]gcggaaggttagttaagaactaaagggtcctgactttagactcacaggaaactgggtttt/c/L OC388458/hypothetical gene supported by BC040718/ 4052/3/rs3774245/181081410/[a/g]/gcttcttccttcttttacagtgcacgtaaccagtgtttgactagctc attgtgagagata[g/a]aaaattcaaattggagaaggtccctacagctctacctttccaccagtccctgctgtttca/g 40 /PEX5L/peroxisomal biogenesis factor 5-like/ 4053/10/rs17295437/31189551/[t/c]/tgtgcctctcttttgacactcacgctggtagctcaatctttcctaa catctaatccaatc[c/t]gtcttgccaggctctttgattccctgtccagaacccactcccacttgcccttctgtaaat/ c/ZNF438/zinc finger protein 438/ 4054/2/rs1394431/98364441/[a/c]/tcgggaacgtccattttcattccatatttgtatggggagtggcagtgg gtatttgtatgt[a/c]atagatgatgcaggggatggcgaacggcacgggcatttttaagatggaatatgagagttc/a/ CNGA3/cyclic nucleotide gated channel alpha 3/ 4055/10/rs2763342/71238584/[a/g]/cacaaattagctgttgatgtaaggtccccctgttagaggctggggaa ggtttattagtca[a/g]ctctcctcgcagcgtccccggccctggacccagcaataggctcagcatttgctcaggggg/a /COL13A1/"collagen, type XIII, alpha 1"/ 50 (288) JP 2010-88432 A 2010.4.22 4056/10/rs7069578/84169867/[a/g]/ctgccgctctccctgaaggacctggtagagtacttccttttgaaata tctggctgcagtt[g/a]gcctatagctcagtctgggtttctggcttgttctgtgcatttgtttttcgtgcttcaatt/a /NRG3/neuregulin 3 4057/13/rs4772380/100855215/[c/t]/gtaaacactaccttcaaacatctgtgccccttccttgtctttcttg tcccatagctcatt[c/t]acatgcttatacgtgcaaggccttacaaggtgagctgatataagcacagctttccagatt/ c/NALCN/sodium leak channel 4058/5/rs12653662/59675294/[a/g]/tttggctacaagactggagggtcgaaagatgggaacaccaagatatt tctctcctctctc[g/a]gtgccttgagcagaatctctaccatcaaaaagctttctcccatgcctcctccagttacac/a /LOC653198/similar to phosphodiesterase 4D 4059/11/rs7131110/43803426/[t/c]/aatctattttttcctttttataccacagtgtattcattgtatgtcac 10 ttagccagaagtg[t/c]cttatgcgatgccctgcccatggagtagatgataaaagtttagatgaatggacagatggg/t /HSD17B12/hydroxysteroid (17-beta) dehydrogenase 12 4060/10/rs3781490/21121849/[t/c]/tatgtcttgtgatcagatgtgaataggacttgaggctttgacatgaa actctcagtgaca[t/c]gtgtaaaagcaatttgagcagaaaggtccataccatggccgtgtgttataaccaagcagc/c /NEBL/nebulette 4061/19/rs4805574/35705601/[g/a]/atcttaaggatttgttgattatttattttaatatggttctaaatata tatatttgtgttt[a/g]tacatgcacataggtatatatattttaaacagcaaccgttagtatcatctggaagggagt/a /ZNF536/zinc finger protein 536 4062/3/rs1447675/74233758/[a/c]/tgatgggatagcctataaactacgagtgtttctttgacctgcctctct tagaaatactct[a/c]tctgtctagtcttctttaaagtggaggatcactttggtgccactgccaatgggatcaaca/c/ 20 HSP90AB5P/"heat shock protein 90kDa alpha (cytosolic), class B member 5 (pseudog ene)" 4063/22/rs133036/39342384/[c/t]/tgcattttaaaactctggcttcagtgtggagaattgactgaagggagt tagagagaatga[c/t]ggacggaagaaaaccaattaagcatttatttaattggtttaactggaaatagggtggctt/c/ MKL1/megakaryoblastic leukemia (translocation) 1 4064/17/rs9901675/7425536/[a/g]/cttcttggcctcctcgccctggtgcttattgctttctgcatcatccgg agacgcccatcc[g/a]cctaccaggccctctgagcatttgcttcaaaccccagggcactgagggggttggggtgtg/g/ CD68/CD68 molecule 4065/13/rs2762051/49733716/[t/c]/gagacttgacaaattttcatagcctaaggctacagtctttattgcca gagcagtaagcca[c/t]ggaacatagtcattgtggtaggaaagatttttgtctgtctgacgtctttgtgggtatcat/c 30 /DLEU1/deleted in lymphocytic leukemia 1 (non-protein coding) 4066/11/rs9328566/673403/[a/g]/atttttgtaccaagtgtgaagtttaggtcatcctttgtctctgctgatg aacgtcctgtc[a/g]ctccaaggccatttgctggagtctactatgacactctagtctgacccagatcgtggggtc/g/D EAF1/deformed epidermal autoregulatory factor 1 (Drosophila) 4067/3/rs982953/24486257/[t/c]/ataaaaataagttacccaaacggttttccattctttactcgtacctcac tctttaccacg[c/t]gctcatagtttgttgctcttcaacacttttctctaaataagttaataaaatgtattcttc/t/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)" 4068/2/rs6736284/133978286/[c/t]/tggtgagtccttggttatatgaggaatctttctgggaagaagaaaag gcaatccctggtg[t/c]atctgttgtataaatctgggtttacaccaatagaatcttcttaaaacaaggtttgggggc/c 40 /NAP5/Nck-associated protein 5 4069/11/rs606561/99003084/[c/t]/cattcacatggtcagtgacaaatcttggcaatctcatggagtgtgggc accaacaatttt[c/t]gctgcctgcaacacgaacagcgagcctctcaggggacaggcttctatccaccaatctttc/c/ CNTN5/contactin 5 4070/10/rs580293/84668283/[g/a]/tcatatccattaatcaacttgccacgtaagttggcagaatgtactcat actgccagtgcc[g/a]agcaactccacagtatcttgaatattggtaaaagagaagataacttactttcccaagcaa/a/ NRG3/neuregulin 3 4071/13/rs1172484/47269211/[t/c]/gaccttgtcccatatgctaaaggacctgaaatctagagaacaacttg acacatctatttc[c/t]agccagagcagcagtgactggcaggaagacaaagaggaggcgggtctataaggaagacgt/c /LOC730174/similar to Nucleosome assembly protein 1-like 1 (NAP-1-related protei 50 (289) JP 2010-88432 A 2010.4.22 n) (hNRP) 4072/13/rs1172498/47279089/[g/a]/tatttttcagatcagttttagattcacagcaaaattgtgtggagagt acacagagtttcc[a/g]tattccctgccccgacacatgcatagttttctccattatcaacaccccccacaagactgg/a /LOC730174/similar to Nucleosome assembly protein 1-like 1 (NAP-1-related protei n) (hNRP) 4073/16/rs7190825/75885243/[t/c]/gttcacaacagggttcaaactcctctgagaacctaacgctgccactg atttgacaggagg[t/c]ggagtttagtctgtgatgctggcctgctgctcatctcctgctgggcagcccagttcctta/c /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18" 4074/1/rs3766306/17842165/[t/g]/ttcactgcagcaaaagttttaatggaagaagagtcatttgaaatctta tttgaatgcctg[g/t]gttcccctggggcttgaataatttgtttcttttattttgccagtattttttttcttttta/g/ 10 ARHGEF10L/Rho guanine nucleotide exchange factor (GEF) 10-like 4075/8/rs10955984/121736022/[a/g]/ctatggaactatttctgataacagcccatcccaaccccaaggaatt atacgctcactctc[a/g]atgtctgccaagatgagccgtttcgatccagcttggcacggcgtatgaatgatatcacag/ g/SNTB1/"syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic comp onent 1)" 4076/15/rs1866007/58605542/[c/t]/ttcgtgaatgaggccgcctgctctttctaaagaacaactttttttcc tcatatgcttctt[c/t]gaggactcttatttctgacccccacccaactttaattttataatttcatctgcttgattt/t /RORA/RAR-related orphan receptor A 4077/18/rs431856/38175145/[a/g]/taagggaacttcagataacaatttcatactgtcctttgggagagacag gattaagagata[a/g]tgggagctgtggtcaggggtcggggagtggagatgagagagaccttgaggcttcttcttc/g/ 20 LOC284260/hypothetical gene supported by BC011527; BC021928; BC011527; BC021928 4078/17/rs7503263/26768625/[g/a]/acaggcactgtcctttcccctcttttcccatctgtcttctattgtgg ctgctaaaacagc[a/g]taaaaatgctggggagtttcaacttcaccctactccaagccaagccctgaaacccctttt/a /RAB11FIP4/RAB11 family interacting protein 4 (class II) 4079/1/rs12406278/188861591/[a/g]/cataaataactataaatgcatgtacacatatatatgaatattttag aatcatgagttcac[g/a]cctatcccaccaatttcagtctatccccatggagttcttgttgcctttctctatttcatg/ g/LOC440704/hypothetical gene supported by BC042042 4080/1/rs4915896/63599614/[c/a]/agcagatgctcagaaaacatttgacgaataaatgatattgagtaaagg aagtgttactta[c/a]tatggtagcctttagagagagattttgttggcctggcgtgatagctcatgcctataatcc/a/ LOC441887/similar to DnaJ (Hsp40) homolog 30 4081/4/rs314091/189683236/[g/a]/attagactgacaataactagaaagaacaatagagcaatatacaaatag gaattatgatgt[g/a]gttttgataaacagtaaaatattgctaatgtgcagaaatttattatacaataaaagtggc/a/ LOC401164/hypothetical gene supported by AY494056 4082/14/rs942740/90228622/[a/g]/gtttttaaggctgatggaaacactgcttatgaatgtcattagatggag aaactttctaac[g/a]tccaatgtaaatcaagataccagtgagagtcaacaatatgaacaaatgctccatacttaa/g/ TTC7B/tetratricopeptide repeat domain 7B 4083/9/rs10116217/72504429/[a/g]/gatcactaagctgataagtgacagaatcaagatttgacctcagatct ggagcctctctag[g/a]ctttcttgctaaagtaaaacactgttagaggtaactaaatcttggagtgaggattggagg/a /TRPM3/"transient receptor potential cation channel, subfamily M, member 3" 4084/1/rs4649440/231382792/[g/a]/ccacacacacctggtgctcccaccaacacaaacatgtctctcataca 40 ccaagaagaaaac[a/g]tctacatatttaatcttctcaatcaccatcagcagaatcactgatgccttctgaaagctg/g /PCNXL2/pecanex-like 2 (Drosophila) 4085/2/rs7568834/71659620/[t/c]/tgctgtctccatcccgagcattattttattttcgtattattctttttc cagctaatatcc[c/t]ggcatttccaaagacaccgggtttcataatcttcctggcgttcccagggagctgggaagc/t/ DYSF/"dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)" 4086/7/rs39335/103240805/[g/a]/tgtattaatatgtagaaagagaaagggtttccagtgaccttccagggaa acaaacgtagt[g/a]tctacattaacatcctcatcattgacctaaaacagagggaaaagagcaagttaattaagt/a/R ELN/reelin 4087/2/rs935480/134812772/[g/a]/gccagggatgaaaaacaacaaaaatacaaaattttcatgatgatataa taggaagctctc[a/g]aaggttggattcaggtaaggaaatgggggaaagtttcctgataccctgacaaagacaggt/g/ 50 (290) JP 2010-88432 A 2010.4.22 MGAT5/"mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransfer ase" 4088/7/rs10255137/83008913/[g/a]/aacgggagattatggaaggggtgtcattttggcttaactttgccctc tttaagcagatag[a/g]agaactttggacaacaaatgcagtattgccagcaaatgcaagaaaacagcagtcatgatg/g /SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E" 4089/7/rs6962998/157179774/[c/a]/actttaaaaatcgtgagagggcctgaaaggttccatgcgggttcacc agcagaacagcac[a/c]cttcctcgtccacgccttggtgcacctgcggcaatatattctgggtggcagacggttatt/c /PTPRN2/"protein tyrosine phosphatase, receptor type, N polypeptide 2" 4090/4/rs4697525/24627723/[c/t]/gaagctgtagaaaccccacctaagcctttccaatggagatactcacca 10 atacctttggcc[c/t]catgttgtgacagtggaggcagttagtattttggttttatcttataacctgaaaaatgta/t/ LGI2/"leucine-rich repeat LGI family, member 2" 4091/12/rs4561260/19222293/[c/t]/cttcatactcctgcacacaacttccacggctcctggtgtgctgtgat taggtttctggaa[t/c]cattgagcactcacccccacccacgtttcagaaatctccttggtctattattccagtgtg/c /PLEKHA5/"pleckstrin homology domain containing, family A member 5" 4092/2/rs2115366/8381482/[t/c]/tgaatttttaggatttttattgtttgaaatctatcccaaattttaaaag atccatgatcc[t/c]gcttatgataagtctgtgccaactctaaaacagctattcttatcttcagctgcaggaaaa/c/C 2orf46/chromosome 2 open reading frame 46 4093/18/rs8084760/8782044/[g/a]/tttgcattttctgttcttgggtatgatcttcactcttgactacccagg taccgattagga[a/g]gaacaaacagtatcctcagggagaagtagtagataagttaaagggactcagaatgaacca/a/ 20 KIAA0802/KIAA0802 4094/8/rs4734546/102683746/[c/t]/agaagtaaaaggcatccctctcacagtggaagtgtttgtgatgttca tgttgtggactta[c/t]ctatcaggagcagttgcatttgcattcaaattcccgttggtaacgtctgcacagaaactt/t /GRHL2/grainyhead-like 2 (Drosophila) 4095/7/rs11763291/21846711/[t/c]/taggcctcataagaagtttcactctaagcagcttaggccgctttgag aagttccagtatt[c/t]gtggttttggcttctctgtctcttgcatgaattagaaagctccccctttactagatcctc/c /DNAH11/"dynein, axonemal, heavy chain 11" 4096/9/rs6597551/134040544/[g/a]/gttcagccttcctgtgtctggctcctgaccgctcgctagggttagga aggattaggccac[a/g]ggctctgaaggagcaagaggggcaggagggcaattgaggggcaattgagaggaacccaga/g /NTNG2/netrin G2 30 4097/8/rs2979715/80724814/[c/t]/atttcaatgattgagttcagtgtgaggaggtttatgcctagaaaaggt gctcaccaataa[c/t]gtgcctcagttcccataatagcaagatcgagaaggttctttagtctcccggaacgtcacg/c/ STMN2/stathmin-like 2 4098/14/rs3783684/56162653/[c/a]/ccagagcttgaagaagaaacacttatttcatgatttattttttctta taaagaagacttc[a/c]gaatgtctttgtaaatcccaaagttaaattatcccttgctaagaacataataatgtggta/a /C14orf101/chromosome 14 open reading frame 101 4099/6/rs379908/105630372/[c/t]/ggctcctggtcaatgagtgggcaaaatggttccctgaattggataaca cagtgcatacca[t/c]ggtgactgataaaattgatgtgtctgcaggagagccagccctattactgaagcctttaac/c/ LIN28B/lin-28 homolog B (C. elegans) 4100/19/rs10405617/10613968/[a/g]/gggttgggatgtcactaatccaaagagggtttctcagcaggggaag 40 gatgtggtcccagc[a/g]taggatggactcagggggtgggggctgctctgggaaggacacggagcagggacagctcgt/ g/SLC44A2/"solute carrier family 44, member 2" 4101/19/rs2738039/10654749/[a/g]/agggctggcagtgtatgaagagcagaggccctgcctcagtcctgcca ctcctcccatgtg[a/g]ctggaatgcccatagctgagtttgtcggtcttcttttctgttttccctgagaacgtaaaa/g /ILF3/interleukin enhancer binding factor 3 4102/3/rs2772480/67668411/[t/c]/ggctggctggggactcctaggaccctccaacctcacttttagacgtgc cttttctcagct[c/t]ctcttgtaagtgtgcaagcttcgattcctataataaatcccttgtctataagtcatagta/t/ SUCLG2/"succinate-CoA ligase, GDP-forming, beta subunit" 4103/14/rs149670/71701970/[t/c]/cagaataaaccactagaccacaacaaataaacgcaaagcccccaagga atcccagcaatg[t/c]gcttttgaattgtgagctaggagaaagatgttggctatacagcataactgcttgcagcta/t/ 50 (291) JP 2010-88432 A 2010.4.22 RGS6/regulator of G-protein signaling 6 4104/10/rs2281585/105361011/[t/c]/ctgaccagggaaagctgaaaggcttccaggctagcatggacaggag ccccatttccagcc[c/t]ctggcaatgccctggctggacacttttgccgggcagtctaaatgtttatgtctgccaatg/ t/SH3PXD2A/SH3 and PX domains 2A// 4105/17/rs9912533/2806774/[a/c]/ggggataggaagtggggtggcctctgtgtgttttgttggggtagagtt gccagcccctca[c/a]gcttccattccgcttcccttttctcctttttgtttttcctggatacacaagggtggcacc/a/ GARNL4/GTPase activating Rap/RanGAP domain-like 4/ 4106/18/rs1469580/64802946/[c/t]/tatataagacacataaatccttcactgtggaatatttaagttttatc tctcactctgtgt[c/t]ggtatttctaaaagagaagcattgaaatccaaagttaggtaaataattaaaataaaattg/c /CCDC102B/coiled-coil domain containing 102B// 10 4107/2/rs2241057/72215468/[c/t]/agaaggggctggagaaggccatccgggagaagctgcagtgcacacagg gcaaggactact[t/c]ggacgccctggacctcctcattgagagcagcaaggagcacgggaaggagatgaccatgca/c/ CYP26B1/"cytochrome P450, family 26, subfamily B, polypeptide 1"// 4108/11/rs2298525/120866225/[a/g]/attagagctgcaagtacaatgatctcactgtgggagagagttgggg ggaggagaaagtaa[g/a]gtatttatgagaggagtggtagagcttttgcatttttcaatcaatcagggaacccagggg/ g/SORL1/sortilin-related receptor// 4109/3/rs1023880/56026819/[t/c]/atcctggctctaatggagtttagactctagtggaggtgatggggagac agacaataaata[c/t]gtgacattcctaggatttcagagggtaatattttctacaaaagaagagaaggcagggagg/c/ ERC2/ELKS/RAB6-interacting/CAST family member 2 4110/2/rs1905925/141013082/[t/c]/tagtattgagtgttttctgcttctttctggaaacatcatggttcagc 20 tgcccttattctc[c/t]tgcacagcaattacttcatctaattatatttactgtatctatttcttttatggattacaa/c /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)// 4111/1/rs6672549/107676482/[g/a]/gtctctttatccttaattccctagtgccatagattttttaagctagt gggtcgttaaagg[a/g]aagatgtctcttttttaagaaacataaggatatttaagcaaaataccacaaaatggataa/g /NTNG1/netrin G1// 4112/16/rs7191801/25908174/[c/t]/aatgtaacaaaagtaaagtgaggcacaatacaaggttaaggagtttc tttgagcaaacag[t/c]gatttatgaagtgaatctattaatatgagtgatctggggacaccactgcggtgacataca/c /HS3ST4/heparan sulfate (glucosamine) 3-O-sulfotransferase 4// 4113/22/rs5750960/39289866/[c/a]/tcaagtacaagcaaattaatatggcagtggagttagactggattgga aaaaagaaatatg[c/a]ggttgtggggggaggttacaaagctacttcattaggcaaagtataatgtgttgatatcct/c 30 /MKL1/megakaryoblastic leukemia (translocation) 1// 4114/2/rs1344733/55981531/[c/t]/cttttcctcagagtgctatcctacttcattagtgccgctttgttgaaa aataagccacta[c/t]cctgcctcttattgagatacctattccttgggaccccaagaaaattcatgttagattttg/t/ EFEMP1/EGF-containing fibulin-like extracellular matrix protein 1// 4115/12/rs7960795/100743750/[t/c]/gtctcatagtttgtaaacattttttaaacaatgaaacctttcccag aaaacaagtccaca[c/t]gaaatagataagaggggctactcccaacccacaaggcagctgggagtaactcagtttggg/ c/GNPTAB/"N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits"/ / 4116/2/rs1385775/140995571/[t/c]/ttcccagacaagcaattgttaaaggactagatcaccaccagatcagt actagaagagagc[c/t]tgagggggttctttgaatggaaatgaaagaatgatactaccacaaaagaacacataagca/c 40 /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)// 4117/4/rs1425339/20909388/[g/a]/taaattaaacaaactcttgtaacatgaataaatcagcattaaatttca gtcaaatcaagc[a/g]cacactttagttgggatctggggtaaaatttgaaaagaaaatagacagaaatgtttattc/a/ KCNIP4/Kv channel interacting protein 4// 4118/12/rs12582396/12627386/[t/c]/aaaccccagtggtatgcaaacaccgtcatggggacttgcttcaagc catgggaagtttca[c/t]gcaaagccagtttctcagtagggcaaatgttgtgtaaaagtacaagaagtttgagaaact/ c/LOC644467/similar to ribosomal protein L19// 4119/11/rs2298813/120898894/[a/g]/ggctcagtgggaaagaacttggctagcaagacaaacgtgtacatct ctagcagtgctgga[g/a]ccaggtggcgagaggtcagccccctcccccaatcccgtcccctccaccctcattcccatt/ g/SORL1/sortilin-related receptor// 50 (292) JP 2010-88432 A 2010.4.22 4120/14/rs8012152/54495317/[c/t]/aggcttaagctcatttttctttttgctttacattctcccccaatgct tgcttacccatgc[t/c]catggtttaaattgctatacttatgccaatgattttcactttgtatctcttgaccagaat/t /WDHD1/WD repeat and HMG-box DNA binding protein 1/ 4121/11/rs1453541/58981797/[g/a]/ttcagcatgggggtaatgaccgtgttattaatggatatggttgtgtc catgggcagcgtc[a/g]tgaagggccggcagtagatgtaaacacaaggcacgaagtgaagagtcaccaccagcatgt/a /OR4D6/"olfactory receptor, family 4, subfamily D, member 6"/ 4122/2/rs929633/40357238/[t/g]/gtactgcccttgactgcaacctcccttaatatttctatcatctactttg ctggccttgat[g/t]taagtagaagtcactcagttgctttgatagatgagagtctctgtcctttaaacctgtagt/g/S LC8A1/solute carrier family 8 (sodium/calcium exchanger) 4123/7/rs2284290/107862002/[c/t]/tgccaaaggaggctcacttgattagagcattcacagtttaagttttt 10 actggaaagcaaa[c/t]aagaacaccagcagtttagatagactgaaactgtttgtttggagaaaacaaaaaactagt/c /NRCAM/neuronal cell adhesion molecule/ 4124/10/rs451123/119244291/[g/a]/ttgacccatgaattatttagaagtatgctgtttaacttccaagtgtt tgaagattttccc[a/g]tggtctttctgccctctgaattttagtaactgtctctgatattatttcatctccatgaga/g /EMX2OS/empty spiracles homeobox 2 opposite strand/ 4125/3/rs4678771/35401563/[c/t]/agttctgttcctccaagaattcagaagaaagctgtaattttcatgagt tcagctattgtg[t/c]ctgtcttacacgctattgtatcctcattactttgaatagcacttgataaatgatggatga/c/ KRT8P18/keratin 8 pseudogene 18/ 4126/11/rs688906/102534726/[t/c]/ttacaatttattatatatttttttcttaaaaaacatgcctccaaaaa ttcatttaatgat[c/t]tctgacatctttgaagctgatcaagtattgttagtagagaatttcttattccagcatgag/c 20 /DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1"/ 4127/11/rs589623/102587800/[c/t]/aataattcctttttcttgctactactaatggcagaatacacatgtaa aaaggtcatgtat[c/t]ggcttggtgtagcaccatatgctttacaagattcatggattaataaaaatgattttagaa/t /DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1"/ 4128/11/rs882937/93548520/[g/a]/gctgcataattcatagctggctgtggggagaaggaatgttcatttaat tcttgcccaatc[a/g]gaagggtgcccattagtttaaaaacataagtgcatgacacagagtttctgctgcttccat/a/ PANX1/pannexin 1/ 4129/8/rs4734560/102691766/[g/a]/atttgaagttagcttcacaaaatccccagggagagaatccagctgga aggtagcaataga[a/g]ggaggaagtagtaatcctacaggaaggagggcttgaactgggggaccctgggaatgctaa/a /GRHL2/grainyhead-like 2 (Drosophila)/ 30 4130/1/rs4915897/63604297/[g/a]/gagccgagatcgtgccattgctccccagcctgggcaacaagagaacaa gagcgaaactgc[g/a]tctcagaaaaaaaaaaaaaagacctgtacatgtttcttcttgcattgatctctccctttg/a/ LOC441887/similar to DnaJ (Hsp40) homolog/ 4131/8/rs2981092/73998473/[a/g]/ggtccattcaattggttggggggcttagaattttatttttggtttaca gactatacattt[a/g]tctgtaccaaacttattgaaattagcaacatgcacagaaatgggctaactggcaattaca/a/ KCNB2/"potassium voltage-gated channel, Shab-related subfamily, member 2"/ 4132/3/rs2669910/114795826/[t/c]/acgactaaaagggagaggagcatttagcactttaaagccacgagagc aggtgttctttta[c/t]agtcttttatattgacagctgaatgtttataaaacaaagtgcttgggtggctggaaaaac/t /SIDT1/"SID1 transmembrane family, member 1"/ 4133/12/rs4149577/6317783/[t/c]/gaggctagaagacacttgcaataacccaggtgtgaggcaacccaggaa 40 tgcggagaggac[c/t]gagagatcacagggggaggcctcgcaagatgaactgacacatgggatggcggcagggata/c/ TNFRSF1A/"tumor necrosis factor receptor superfamily, member 1A"/ 4134/2/rs6718486/180051118/[t/c]/accccaagtttccatcctgactctactgggatttgagttgtgcaacc tgacataaaccac[c/t]taaccttcccataacccaggttcttcattgttactatagttttgggagcagcttgaaggt/c /ZNF385B/zinc finger protein 385B/ 4135/4/rs2089503/48291244/[t/c]/gaatctcttctttttttccagaattgtacccactcccttgaattagtt accttcctccag[c/t]actccaccagaattataaaactcctttcaaacagcagttaatctaattagttaacttccc/c/ FRYL/FRY-like/ 4136/8/rs996955/139447407/[t/c]/tggattctaattattagtgaagcttgatttccattttttttttctttt tcaccaaagcaa[t/c]tgtaaatagacgttctaatactttctttccacatcctgatggctgtcttgtgcaccctgg/c/ 50 (293) JP 2010-88432 A 2010.4.22 FAM135B/"family with sequence similarity 135, member B"/ 4137/12/rs2270588/69812681/[a/g]/aggtgagaactaaatcacatttggtacaataagcaattctgttactt tcttttcacaatt[a/g]aagtccctacaaaaaattaaaatgcatggagtaccatgggaatcatgatataaaaatctc/g /TSPAN8/tetraspanin 8/ 4138/18/rs4798619/8271595/[a/c]/aggagtgcttgactgcaccataaactaagaacccacagcttcttttgc ctcaactctttc[c/a]gcaaccctgacctttctctagtggatgcaggaaagtttcaataaccctaagaaatgagtg/c/ PTPRM/"protein tyrosine phosphatase, receptor type, M"/ 4139/2/rs11896729/98592077/[c/t]/tggaggggagacgggcagccgggcagtggccggcgttccccggagct cggaccggttgga[c/t]tggactccgacgctaccgctccctctgctgaactattccggatgtaaaacactagggatc/t /UNC50/unc-50 homolog (C. elegans)/ 10 4140/3/rs7433810/74600103/[t/g]/cctgcaatgatacatataacatgttttgtattcaaaaacaacatttac agatgttaaaat[g/t]ctattgatatctcaagcaaaatcttgagtctagatgtttcttacggctggtaactgacag/g/ CNTN3/contactin 3 (plasmacytoma associated)/ 4141/14/rs1958022/32769255/[g/a]/tttgggatagccagagcacagaggacagatctgaaaacagaccaggt tttgataccagaa[a/g]aactgcatggtgtctatgatgttaaactacagagaattaacacataatagtttggcgctg/a /NPAS3/neuronal PAS domain protein 3/ 4142/15/rs1597196/25968517/[t/g]/aatgctgcatgagttcacgtgtatgaaatatctacaaaaggtaaata cagagacagaaag[g/t]aaattgcaggttccagagcctgtggggaggaaggcacggagagttattgcttaatgagca/g /OCA2/oculocutaneous albinism II/ 4143/21/rs378528/43325524/[t/c]/acccatgaaagccagccagcccttcctccttccctcaccaccctccgt 20 ctcttcggctgc[t/c]tgctctttagtgtagattagtggaagccattcacagaatgtagactcatgtataggtcac/c/ PKNOX1/PBX/knotted 1 homeobox 1 4144/11/rs2285391/113513880/[t/c]/agcccacgccttgctccttgccttcctaagaagctgccagcacagc aacacctgcctgag[t/c]ggtcctctcaccgatgcacagcatggggctggccacactcatcaccaacatgcagatgtg/ t/ZBTB16/zinc finger and BTB domain containing 16/ 4145/6/rs9347171/167344031/[t/c]/tgtctggagagtagggagaagggaagtgaggaagtaaatcctggaat ggtagacctggga[c/t]agatttcagtggagaaagacagtatcctgttcaaagtgaataaatgaaatattttgcagg/t /FGFR1OP/FGFR1 oncogene partner/ 4146/8/rs1045574/143760960/[g/a]/gccaggtctggtccgtggtgtcccccgcacccagcaggggacaggca ctcaggagggccc[a/g]gtaaaggctgagatgaagtggactgagtagaactggaggacaggagtcgacgtgagttcc/g 30 /PSCA/prostate stem cell antigen/ 4147/7/rs4909081/157893546/[g/a]/tcttcagaagttgaaataggaaaggaaaaggcaacacttagaccaaa tgctgaagtcaac[g/a]tgacatgtaggatgtgatttgttaagttacactgacatctggtggccttcagtgttagaa/a /PTPRN2/"protein tyrosine phosphatase, receptor type, N polypeptide 2"/ 4148/4/rs4862580/187030881/[g/a]/tttatagattaatttcaggaagagaaaaagagaaatgtggttgggga gagggagaaagag[a/g]gagggaggatcttttcttcctttctcctgagcttccatcttgtcccacagaggtgggtac/a /SORBS2/sorbin and SH3 domain containing 2/ 4149/3/rs4683045/45129872/[g/a]/ggctaacagctaataacatcctttgatatatttgtttcctaagccttt taaaacaaagca[a/g]gaaatattatcaaagagaaaacaagaggaaagtgaggggacgaaacagaaagtaggcaat/g/ CDCP1/CUB domain containing protein 1/ 40 4150/21/rs2269169/43055586/[c/a]/gccctggggacccaagggaacccctccctccttcctcacctcctcca gggcccagagtgg[a/c]gccccaaaaagagggtaccctcgccatgcgcacgtgcatcccactgacctgcacttccca/a /PDE9A/phosphodiesterase 9A/ 4151/16/rs7204290/55525540/[a/g]/ttgtttaaacagcttgctttaattatctcaagctacttggcaggaac acctttattccag[a/g]tttcgcataatcagttattctggcaagagtagattaacacgttagtgatctccaatagac/g /HERPUD1/homocysteine-inducible/ 4152/6/rs7751374/108088549/[a/g]/gagagacttttatttcagccttatgtgaatggggtgggtccgtttgg ctctttgatacct[g/a]agttaaatatcagaaagttcctaaggtggaaagtatgctaatatctagttctagtcattg/g /SOBP/sine oculis binding protein homolog (Drosophila) 4153/4/rs714462/160105220/[t/c]/ttataaaaaatggcattcggactagcatgcaaggggagaaaaggaata 50 (294) JP 2010-88432 A 2010.4.22 taaaaaattctt[t/c]gactggctattttagcttaaaagccacattccattttcattacagtcatgtattagtccg/c/ FLJ25371/hypothetical protein FLJ25371 4154/9/rs9942952/8983618/[g/a]/atgcaatgatatatttggatcaaaattttcctaaaattttcagggaaaa tcaactaagat[a/g]attatatttttcctgagcttaaatggaagaaaatcttatgtatcttagaatttttgagtt/g/P TPRD/"protein tyrosine phosphatase, receptor type, D" 4155/10/rs7079180/127780295/[c/t]/tgcttattagttactgaaaatgaatctgtattaatttttcagcaaa gtctcagctctggc[c/t]aacactatcatattctgtcacctataatcaacgcaggttttaataaaataaagaagtcaa/ c/ADAM12/ADAM metallopeptidase domain 12 (meltrin alpha) 4156/7/rs17282/141924465/[a/g]/gcagggagatgcttagtcctgacctgcctgactctgcctggaacaccag gctcctctgcc[a/g]tgtcatgctttgtctcctgggagcaggtgagtcctgagtacaggtgggacatccctgtat/a/T 10 RBV13/T cell receptor beta variable 13 4157/17/rs7219493/70555783/[t/c]/ctctgccaagttgggcttccacagctgcaggaagcgctccttgtgat atcacactgcttt[c/t]ctatagtcctggtcgcagaacttttatctgttaacagtcactggtttaggtccatattta/t /KCTD2/potassium channel tetramerisation domain containing 2 4158/17/rs10512598/70549727/[c/t]/atgacagccagatccctaaggaagcttaggaaggatgcgtatggcc aaaggccttgtggt[c/t]gattgaactgtaaataggtgcaggaatttaggctctgttcattcagcagtagagtgtagc/ c/ATP5H/"ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d" 4159/11/rs2510094/102486510/[c/t]/gaaatgatatatttcaaaataaagtttgaattcttttttggtgtac atcatgtgatatac[t/c]gatttattaattgcactgctccctccactggcaggattgcttaaaaaatgggttgcattt/ t/DYNC2H1/"dynein, cytoplasmic 2, heavy chain 1" 20 4160/1/rs12036544/231378780/[a/c]/tccttcttccttttcttctcccgtgctccacccagtgtggttgccc ccttctctgtgacc[c/a]agccataagtctaaagtccaagggccccaagcaatcgctatgcagacatcaactttgaaa/ a/PCNXL2/pecanex-like 2 (Drosophila) 4161/15/rs10520775/93627801/[c/t]/aagtttgggcttctaaggaagtccaagagtagctgactggtggata actaagcaacaatg[t/c]gaaatagggctccacggctgtctagcaacagacatgggtagagatccaagatggagggca/ t/LOC400456/hypothetical gene supported by BC040875 4162/2/rs10497264/166137627/[g/t]/tattttaaaaatttatgggtaagaaataaattcatccaataatttt taatctcctgtgta[t/g]gcagaaataatataaaagagaatactactgacaaatagttcacataaaaagcttcaaaat/ g/FAM130A2/"family with sequence similarity 130, member A2" 4163/5/rs3776221/142570426/[t/c]/ccatcatatggcactacagggaggtgggaccagctagactggcaggt 30 ggaaaggggttga[c/t]catttaggcataatttccagggacccctgggcaaatgcaagttacgggtttggggctatc/t /ARHGAP26/Rho GTPase activating protein 26 4164/9/rs632562/4030641/[a/g]/ataaggatatagaaggaatggaaaaaatctgaacgggaactcccagcact ttggagaact[a/g]ttaatgtggacgataaagacagagtttcttcagtggaactaagtggatagtgagttataa/a/GL IS3/GLIS family zinc finger 3 4165/13/rs553316/112886016/[t/c]/agtcttctttttgtaatttttatcggctgtcacggcatcattcttgg tgatctcttctct[t/c]gtgctcaaaccagactttaaactcttcttcagctgtttgtggagcacacagtcccaagta/t /PCID2/PCI domain containing 2 4166/17/rs410157/544990/[a/g]/gtcatctttctatttcactacacataggccacatgcaataacattttatt caactgagcc[g/a]ggcacaatggctcatgcctgtaatctcaacactttgggatgcctaggtgggaggatgact/g/VP 40 S53/vacuolar protein sorting 53 homolog (S. cerevisiae) 4167/13/rs9557286/99199677/[a/g]/gcctgtcctttatctgatgtccaacccttttcatgggtttccatgac aaatagagtggcc[a/g]gggtagaccaggagggccgttccttcccggtgcccctgctttgtaccaggaaccccacaa/g /CLYBL/citrate lyase beta like 4168/9/rs2145926/27183311/[t/c]/aaatttttgaaccccggccccatcctcacctcaaaaccattgaatccg aaactctgggga[t/c]gaggcccagaaacatcttttaacaaactctctgagtgattctgatggacacttaggtttg/c/ TEK/TEK tyrosine kinase 4169/6/rs10485268/102010156/[a/g]/ggagcaggctacattattaatagtgttataggagccatgccttaaa atcattagacctag[g/a]ttagaaatatacttcccaagttaatttaaaaaaaaaagtgactatttcggggagtcctta/ a/GRIK2/"glutamate receptor, ionotropic, kainate 2" 50 (295) JP 2010-88432 A 2010.4.22 4170/9/rs10968388/28200699/[a/g]/ctatgtaaatttgtgttttatgtagacgcagagagagaagagagaag aaagccactaggt[g/a]taaaactggtagagttttatgaatgttggactcacatccatgttcctgatacaaatcatt/g /LINGO2/leucine rich repeat and Ig domain containing 2 4171/3/rs1039631/63503089/[t/c]/ggcttaatatggggaatttacaacacgaaatttgcgagcagtgttact tatcttagtatc[c/t]ccaacgaagggggcatctgatgtttttgcttacctgtatgtattgtttattttctgaaca/t/ SYNPR/synaptoporin 4172/8/rs2030784/102684162/[t/c]/agagctaaactgcatatcagttgcctgggggacatagttgggcatga aaactcaaatgtt[c/t]gccaaagctaggtagggaaagttccagaatgcagaatgctagagaaagcaataaagaaag/c /GRHL2/grainyhead-like 2 (Drosophila) 4173/2/rs1438903/88524894/[c/t]/tttctaatagatgaacagttctgttacttagattaaattgaatttcag 10 tgcagcaaaaaa[t/c]ctactacagaaagaaatgtgctttgaggcctcatgcctcaaggagagctctgcatcctgg/t/ LOC344167/similar to forkhead box I2 4174/1/rs7535533/180763452/[g/a]/ctcaaggaacggaaggctaaaatcccattgcaatttctcacagctgt acagaagatcagt[a/g]tagagaccaatgaaaagatttgcaagtctctcatagaaaatgtaatcaagactttcttcc/a /RGSL1/regulator of G-protein signaling like 1 4175/9/rs991849/28188623/[g/a]/tatgccaagtgagttttaaaaatggaagtgtcttgaggaacttccagct gctgagaggtc[a/g]caaccatcacttaacaaaaatcatcattttttttccactatactttttggtttctcattt/a/L INGO2/leucine rich repeat and Ig domain containing 2 4176/6/rs1492577/150972824/[g/a]/catacctgcttcgtaggtgcttgtggtgaggggagttcacccagcat cgcgtcac[a/g]gcatcacctggagccatgagccgctttgggtacttttcttggggaactaaaggagagagg/a/PLEK 20 HG1/"pleckstrin homology domain containing, family G (with RhoGef domain) member 1" 4177/2/rs207818/216855159/[g/a]/tttgagattttgaaatgaattgaagatggaaccagcagcagggaaagg cacctctttatg[a/g]ccccttggtatactactaagagggctaaggtgcctggggcttttagtgccaccttccaga/g/ MARCH4/membrane-associated ring finger (C3HC4) 4 4178/7/rs4729707/100856824/[t/c]/atgcagactgaggccaaagtatgggtgagctatgaagagaatcagaa gcaggtcccagca[c/t]gtcagccgaggcagctcccagcgggcagttctggcctaggcatgccttgatcttgcattc/t /EMID2/EMI domain containing 2 4179/2/rs525428/169446158/[a/g]/caatgcctgtgcataaacctggccaaacctctctgctgggaaaggagt aaccctggcagg[g/a]ccacttcttcctctgtttgttggaagaaagatacaaccgctgctacttggggcccattgc/g/ 30 SPC25/SPC25 4180/4/rs6847164/120754182/[c/t]/ttatatacatattggatgtttctggcatatgaagttaggtaaatgta cacaaataagtaa[c/t]ggaaaagatgattgtgaacatgtccaatataaaagtagaaagcaacggatggaaatccag/t /PDE5A/phosphodiesterase 5A 4181/7/rs1637490/87466881/[c/t]/aaatcaattctgataacagaataagcatcgtaagtttcccctctaagt tttaaaatgttg[c/t]aaatatttcaaaaggtacttgtaaatctgtaattatgtattaaaaacaactatctgggtg/t/ ADAM22/ADAM metallopeptidase domain 22 4182/10/rs2026612/7845487/[a/g]/attcatgattgttggagaaatatttctttttcatccatagtttctact cagcgttgatct[a/g]ttttcttactaggacagatagtatgtatgaaggcccatcagcacctcttcaaaacctcag/g/ KIN/KIN 40 4183/1/rs2181453/78469110/[g/a]/gcacatagtaggcactcaataagtacttgttagttaaatgtatgaacc tgaggctatagt[g/a]tgaaagatattgagtgccaggctagtaagtttggaattcacttagtagacactaggcaac/g/ MGC27382/hypothetical protein MGC27382 4184/1/rs2473621/208726818/[c/t]/acagtataatcagcaaatcaagctttcctttaggctggcagcctgtg caggatttaatga[c/t]ggaggggagaggacacttacctgcccattgctcaagccaataggaagataatcaagaggc/c /HHAT/hedgehog acyltransferase/ 4185/2/rs2452477/143473225/[t/g]/gcttttattaaatcactggttcatttttaaaaacctgctcccgatgg ttttgcattttct[t/g]tgaatatcctgggtcatgatggtctatatctacatttggactttaacaataaataactgt/t /KYNU/kynureninase (L-kynurenine hydrolase)/ 4186/5/rs153415/153729890/[a/g]/actatatctgagtcctatcttcagcacataacttgttagctgtgtagc 50 (296) JP 2010-88432 A 2010.4.22 cttggacaagaa[a/g]tgttttctggaccttgtcttgaagtgaaggtgttgaactgggacctgcttccctcacagg/a/ GALNT10/UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra nsferase 10 (GalNAc-T10)/ 4187/9/rs1547635/2170149/[t/c]/aaaatcaggggtgaacgcaagaggtttaagaagactgcattttactcag gaattggattt[c/t]tggatcactgcagcaagaaccaaggtgttctctcaccctctcaaccacccctacccctca/t/S MARCA2/SWI/"SNF related, matrix associated, actin dependent regulator of chromat in, subfamily a, member 2" 4188/17/rs7215005/6608841/[g/a]/aaaaacatttgagctagttgtctataagtaactgcctccatcttttct tctctcattctt[a/g]ttcccactccagtctggctctccattttaaccaaatctgctcttgtcaaaatcaatgacc/g/ XAF1/XIAP associated factor-1/ 10 4189/8/rs7460331/131968018/[g/a]/tggttttttggtcagaagtttttttcatatggcatggaaagtgataa aactccattttcc[a/g]tcttggagaagagatggaaatgacagtccagctgtcctcgtctgaccatacattctgacc/g /ADCY8/adenylate cyclase 8 (brain)/ 4190/16/rs6498807/60358369/[t/c]/ttttaaaatgcaggactaacctttgagctgcaagcatacttcactgt tgggatccacgta[c/t]gtgctttggataaaacaatctgcagcaaaaggagagaatgggcattctatgcagcaagcc/t /CDH8/cadherin 8/ 4191/16/rs6498812/60481092/[c/t]/gaactctgtgaggtttactccccagccccttttaatatatgctttcc tggaatggttatg[t/c]aataacaatttatactatgggtgttcattctaatttacagaactctagacacacatgtgg/c /CDH8/cadherin 8/ 4192/9/rs4744378/96618967/[a/g]/ggttcccatttcgttctcctaaagggatgtgagtctaacaaaggcagc 20 agttcctgcaac[g/a]gtcaaggttctaacagggccacgaaggcctgtgcacatggtgtttcagttcaattctcct/a/ C9orf3/chromosome 9 open reading frame 3/ 4193/5/rs1505875/24588899/[t/c]/ttcggtcttgtctgtcttgcccaacaagagagtccatgtacatccagc attttgttgtca[c/t]attaaaatccaagaataaacacaaaaaaagaggaaaacatgggagattggagaggccaaa/t/ CDH10/cadherin 10/ 4194/3/rs11129942/42156400/[t/c]/tactgtggttcagctgagttttggcgtgaatggaatacggggccgtt tgagcttctggtt[c/t]acttgtgttttgaggcctgtggcacctgctacgtgacttgctggacataggtgtgagatt/c /TRAK1/"trafficking protein, kinesin binding 1"/ 4195/3/rs6787192/152976373/[t/c]/ggtctttctttggttatgccaagaaattgagaaagtgagcacagaga aaatgaggttgag[c/t]gttacaggaacagacacgggaaataacaaatcagatcaaacaggaatcagaaacaggaag/t 30 /LOC201651/similar to Arylacetamide deacetylase (AADAC)/ 4196/19/rs919803/35678944/[g/a]/gtattccagagacagaacagaaagtttgtagggactgagctacttcca ggatggcccagg[a/g]tcattgcatggtacagggtatggggacagagagccaggagcagtggaaaaggcaacccaa/a/ ZNF536/zinc finger protein 536/ 4197/19/rs371671/13731153/[g/t]/gatggggaaactgaggctcagagggtacagtggcctgctcaaagctag gatgtggtgggg[t/g]gagggctggacccgggccttggtccaccatgcatcctctctgaccccgggctggagcccc/g/ CCDC130/coiled-coil domain containing 130/ 4198/11/rs605093/128109442/[a/c]/tttccctatgatcttggtctctgcacacgcacgagaatagccttctt ccatctgagtact[a/c]agctcgatcctgcttagcttccaagatcagatgaggcacgttcagagcactgtggacatg/c /FLI1/Friend leukemia virus integration 1/ 40 4199/7/rs10488600/136255998/[t/c]/catgttaattattttgggaaaagcaattatagccaccttaagctca tcacaccttagatt[c/t]ctatcattgtttctcaaagcataagctcaaaaagcctctagtgactcagtttcctctgtg/ t/CHRM2/"cholinergic receptor, muscarinic 2"/ 4200/11/rs508653/100467410/[t/g]/atattgcctataagtagaggtaatgggcaatgtactgacctgtcatt aagtaacatgtgt[t/g]ggagtctaggctttgctgcccatctcctgtgtgaccacagctcttcctgggcatcagtct/t /PGR/progesterone receptor/ 4201/11/rs538915/100466392/[t/c]/aatcacacatctagtcaatgtcggagccagaagaaagacctgaaggt attctgaccctgg[t/c]gcagccattgttttctccttggcatgcttgccttagaaagtagcagagcatctaatgctg/t /PGR/progesterone receptor/ 4202/5/rs2456220/52202489/[g/t]/tattatcctaagatgaatcaggtcctaataggtatgtacaagtttttc 50 (297) JP 2010-88432 A 2010.4.22 aagggttctttg[g/t]agaactcccttcattgagatatctcacctacacccttgccctgagtgaatgcatcccact/g/ ITGA1/"integrin, alpha 1"/ 4203/11/rs931756/8692238/[g/a]/cagcagagtacatacttgctggacctcacagccaatgttttttgctccc ccaccacccca[a/g]cttttctcacaggggatggatctctaccttctctgggctactctgggcccatggtcaggc/g/S T5/suppression of tumorigenicity 5/ 4204/1/rs4310446/205743227/[c/t]/ttatgaagatgaaactgaggctcagcaagattaagcggtttgcctaa gacctcatagcca[c/t]taagtagaagacattgggttcaagattcaatctatgaacccaacatttttaatactatat/c /CR1/complement component (3b/4b) receptor 1 (Knops blood group) 4205/2/rs1562775/80416641/[g/a]/gactcaactctcccaattccaaatgctgtgtctccccttctatacctg cattttattatg[a/g]aaactttttaatgtacagaaaaattgaagaaattgtatagtgcacacccatgtactcatg/g/ 10 CTNNA2/"catenin (cadherin-associated protein), alpha 2"/ 4206/10/rs7088781/50253121/[t/c]/atagttcacaaggagagtttaagtgggaatattggtagatgcctaca atatttaagcata[c/t]ttttagctgctgtgtttaagtgcagtcaccaataatcaaacaaaaaacaaggccaaattc/t /DRGX/dorsal root ganglia homeobox/ 4207/10/rs12572851/50255183/[c/t]/gaacaggagagcctcgaggtctctggagtcctgcaggtggccagca gtgcaaagccaggg[c/t]caatatctttggaatctcctaagagaggaccttctcccaggcccagagcaacacaagatt/ c/DRGX/dorsal root ganglia homeobox/ 4208/15/rs8041258/67423676/[c/t]/cagctgaacttctagttgtattcaaaccattgactcttccctaaagt gtttatctgggct[c/t]attcagaggagtggcctctttggggtataccatagctgtcacgccagagagaggaaacct/c /PAQR5/progestin and adipoQ receptor family member V/ 20 4209/4/rs6834625/144080798/[g/a]/ttctatgttcaggcagccttcttgacactggggatgcagcagtaaac aagattgtccaaa[a/g]actctaccctgctgcaacctccatttgggatgggattggaaggaaataacctataacaaa/a /LOC729675/hypothetical protein LOC729675/ 4210/19/rs2387137/55829472/[a/g]/aaatgggataagtcattccaaagttatataatgtcataaggattaat gtcacacaccact[a/g]tagcttcactaagcagtacaggaccagaaggcaaccccttcctgctgtgtgtcccctaat/a /SYT3/synaptotagmin III/ 4211/8/rs6985068/10147230/[g/a]/tagaacacccaaaagaagttcgaatcgtacacccattctgctcctctc agtgaggtggac[a/g]gtcaaggattcagagtaggggtggctttggagtgggaaatgttaagatgtgaagagatca/g/ MSRA/methionine sulfoxide reductase A/ 4212/6/rs9380607/36904111/[g/a]/caacaacaaaccaaaaaaaaaaaaaaaaaaaaagaaaggtatgggtag 30 aggctggggtgt[a/g]ccatccgagagggagatacaaccctgcactcagggagcccggtctgaccaggagacatag/a/ CPNE5/copine V/ 4213/4/rs7662504/96147593/[a/c]/ttacctttgccttgctctgcttttcaggaactctgttaggaattatat gagacagaaaat[a/c]atattcaaaacaaattctatttttaatctagttagaagaaccttttttcaagatttggca/a/ BMPR1B/"bone morphogenetic protein receptor, type IB"/ 4214/10/rs1413620/116082745/[a/g]/acatctgaattatgacttcctgttcctgggatgatgctgggaacag ccaaaaagttttag[a/g]gccagattccttatccaatgggcaaggaaggggtggcctgttgaaacatcctgaaataca/ g/AFAP1L2/actin filament associated protein 1-like 2/ 4215/2/rs7568923/165157866/[c/t]/gctttcctgtaaaggcaccaagaaaccattaagccaaaaggcaaagc aaatagaatatgc[c/t]tataataaacctataactacaattatttatatttacataagtaagtacatggggatgtat/t 40 /GRB14/growth factor receptor-bound protein 14/ 4216/13/rs6492624/92077564/[c/a]/ttgaggggcaagaaatacttcattttcccaatgaagagagcatggca ttatttatcattt[a/c]tgcaatggcataattactcagcgtggcagctatagtttatagaaccatactacagcttgg/c /GPC5/glypican 5/ 4217/4/rs2973237/37148085/[a/g]/attttgatattcactgattcagtgataaattattattcactcaacaaa tatgtattgaac[a/g]tctcccaaattaaaactgccatgaaagagttagaacgtagcatctgtagatataattaag/a/ C4orf19/chromosome 4 open reading frame 19/ 4218/2/rs4853811/2000655/[c/t]/attaatacttttaggtgaaacaggtacttaaataaaaacaacaaattaa atccttaaagg[c/t]ccaaaattttgaaaaatataaaagaaattgaaatgcagtctctgccccagaaacctagca/c/M YT1L/myelin transcription factor 1-like/ 50 (298) JP 2010-88432 A 2010.4.22 4219/21/rs2051402/43045878/[c/t]/tcccagggagccgtgaagcacagcctagatccaaaataaaaggtgtc agccctccagatc[t/c]gtccccttacaaaaaacagaaaaacaaatatccagtaagacctaggagaagacagtgtgc/t /PDE9A/phosphodiesterase 9A/ 4220/11/rs7942007/31791994/[g/a]/gagagtgagatttcctcgttctctctggactggtctcaaggaaggtg ggggtgctgttct[a/g]cctcgtggggagcctcactccctctgccaagtaccggctctgggggcgaagcggcctagg/a /LOC729605/hypothetical LOC729605/ 4221/8/rs1541718/3924599/[t/c]/ttcttcatggagaattagctaaattgatacacagacacattgtttcagc gttcttgtggg[c/t]tcacattaatttattcctgtagtaaacttgctttctttccatagtatgaatagcccaatg/c/C SMD1/CUB and Sushi multiple domains 1/ 4222/5/rs3902690/63911893/[t/c]/agaggagtcaggaagccttactgcctataagaagtgagaaaccttact 10 acttactaccat[c/t]ggagagaaaggcagacaaatgtttcatcttcataaaaataagaaatggggaaggaatggg/c/ RGS7BP/regulator of G-protein signaling 7 binding protein/ 4223/11/rs6486334/16972133/[t/c]/tatggcagataattaagtccatgagtaattatggtaaactgtgggga acacaagcttaag[t/c]ataaagtagatgtttcctcaaagtcctcttcaactggggacgatacacacatcagtttta/c /PLEKHA7/"pleckstrin homology domain containing, family A member 7"/ 4224/18/rs2000811/72938316/[t/c]/gtggacaactttctcctcctggaacccatctctcttcttggctctcc tgatagtttccct[c/t]cctctcagctatcagtcacctgggaggattccatctcctctgcataacaaaagatgccac/t /MBP/myelin basic protein/ 4225/3/rs1928565/67662811/[a/g]/ttaaaatattgcttgcttttagttttaatccatttcctcctccctttc ccaaccctatca[a/g]tatatagaacaactgctcagaaaactgttggtttccaataatgcagttattaactatgac/a/ 20 SUCLG2/"succinate-CoA ligase, GDP-forming, beta subunit"/ 4226/14/rs11622943/32315848/[g/a]/tctaagtggagtctaaggaggctaaagtggctaacattgctacagg gcagagtgccaaag[a/g]ggaaagggctacacagacagggcgcaccggagatatacagagggatgctctcaagtactc/ a/AKAP6/A kinase (PRKA) anchor protein 6/ 4227/9/rs10521083/109112961/[c/a]/atacggtcgttgacattgtactgatgaagaaacaggcttagaaagg ttaagtaatttatg[c/a]atccaaacttgagttttctgctcttattatgtactaccaagggctttctcagaactgaaa/ a/RAD23B/RAD23 homolog B (S. cerevisiae)/ 4228/6/rs110691/124479205/[a/c]/atcttagaagcatgctgttcccgcgatagcctaatctgacttcaagga agaactcttaca[a/c]ataaagatagaatgcactgacaaaattcacccataaaccagaaggtacaagtgtgtgaac/c/ NKAIN2/Na+/K+ transporting ATPase interacting 2 30 4229/2/rs1030907/23468532/[t/c]/tgtgagggtgaaaacagataacctccataaacccacattacagtggcc tggggaagtgct[c/t]tgcaaagggggcttaggaaaagtagctgtggaagaagagacagcagcaacccctagagat/c/ KLHL29/kelch-like 29 (Drosophila)/ 4230/1/rs2072739/166536734/[g/a]/gcccacaaataaagactcttccccatggaggctacagcctgcatgac acattgctatggg[a/g]accaactccaaaattagcaaacactaagaacaggagaactccaaaacagagagaccagag/a /TBX19/T-box 19/ 4231/15/rs3794604/25945660/[a/g]/tgcctggccacgcgacggtaccctgtcacgcgatgccctcctggctt tgtggcctctcac[a/g]ggcctacactaagataatatgtgtgaaagccctagaaaagtgaaaaaacactacttagtc/g /OCA2/oculocutaneous albinism II/ 4232/17/rs13912/77298298/[g/a]/ggatgcagcatccgccccgtcggactccttgtcggggagaaggccctaa 40 ggaggaaccgc[a/g]gcccgcctgggccattcccccagggagccaagcgggggggcccaggtgcccgagggacgc/a/S LC25A10/solute carrier family 25 (mitochondrial carrier; dicarboxylate transport er) 4233/1/rs1285679/230778507/[t/g]/gcaaagcactgtaacatgaggttcaccttatacctagtactgtgtct gagtccctgacgg[t/g]actagacgtccactgatgttacgtagattgagactgttgtgcaaccatcaccatcatcca/t /LOC729336/hypothetical protein LOC729336 4234/12/rs2398513/129542529/[t/c]/gaacgaacctgaagcaaactgaattatctcctcaacgtcagatcaa acgtggacttgtcc[c/t]gtgcttggatgctgccttgcctgagcgaagaaattaaggaaaaaccaatttccccaaata/ t/RIMBP2/RIMS binding protein 2 4235/16/rs9923017/25864160/[g/a]/taaattgctttttcccccctttctcaataatatgtcttggaagtatt 50 (299) JP 2010-88432 A 2010.4.22 tacatgttaatgc[a/g]tttttcatgattgcataatattccatagatgactacaccagagtttgtttagtcagtcca/g /HS3ST4/heparan sulfate (glucosamine) 3-O-sulfotransferase 4 4236/6/rs3128917/33167974/[t/g]/cccctggaggtcacaggtgtcctcggccatgggaacgagggtcagata gtggaacctgtg[t/g]aatctgagtttcttgctgggcaggaagatggtctctgcaataccctcaatgactggctcc/t/ LOC646702/similar to HLA class II histocompatibility antigen 4237/6/rs3117222/33168927/[g/a]/catgttcccaataaccttcctgttacctgtttgcttcctgcattctgt gtagcatcctac[a/g]tattcacccattctccatcttctccttcatgcagcagaccatgtgtcaacatatgcggag/g/ LOC646702/similar to HLA class II histocompatibility antigen 4238/13/rs2273816/49192057/[a/g]/aatatgtctgtaaaaatgaacaactttgacataaaaagcggtaaata tggtttgtagggc[g/a]agaaagacaatgttaaatttgtctgaatatcttttaggaaaatgaaaacctgataaattc/a 10 /KPNA3/karyopherin alpha 3 (importin alpha 4) 4239/1/rs9651273/1021403/[a/g]/ttcatgaaggatagtggtctataattttttttaggtgtctttgtcaggt tttggtattgg[a/g]ttatattgcctcataaaacaagctgggaaataggccctcctttttttaaagagagacagg/g/C 1orf159/chromosome 1 open reading frame 159 4240/2/rs12616649/23744418/[a/g]/tttctggaaatgcctaaagcacttcagttcagttgttgccacggtcc tgcccctctctgc[g/a]ttatttttttctcctcctccctgtttgacgtcttccctccatcgtcccgcacccagctgg/g /KLHL29/kelch-like 29 (Drosophila) 4241/2/rs6751684/79877360/[a/c]/aggtccagggtttcaagccaaatatgtgaatcaggttgggaagaaaaa tgcatgtagcag[c/a]atcagttaggtaatgagaagtggcacagtgtgatcaaagcgggttactaggaatgcaaat/a/ CTNNA2/"catenin (cadherin-associated protein), alpha 2" 20 4242/3/rs1587972/116113331/[t/g]/tttatattagtttttgtcctcttactctgtctgtcttctctgggaat tcctaattcatat[g/t]tttgtacacttggtattgtcccataggttcctcatactttcatcatgctttttcagtctt/g /ZBTB20/zinc finger and BTB domain containing 20 4243/3/rs4687841/120436259/[g/a]/catcatattggatttatttacactaacatttaagtaattgagagacc cttaattctcaca[a/g]gagtctcagagttattttctttttcagtcaaggctgtcttgaagtgccaagggactacat/a /B4GALT4/"UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4" 4244/3/rs3773504/143899760/[a/g]/gattcagaccaaaatgtgttaagcttaatagcctttttacaagtttg ctttaataaattt[a/g]aagatgaaggcaatccctctagtcagacactttatataactattttcatctttatcaagt/a /PLS1/plastin 1 (I isoform) 4245/4/rs13109533/153955991/[c/t]/atatttactgtatgacccttcatagaaaaaagttgttgactcctgt 30 tctaggtgatctca[t/c]ccagtcagagatttaagtgcatttacacactgatgtcttctaaatttcttattcccagct/ t/ARFIP1/ADP-ribosylation factor interacting protein 1 (arfaptin 1) 4246/4/rs6822347/154003718/[t/g]/gttataggctaatttgcagttaggttaactattatcattgtgcaatg taaatctaagtaa[g/t]ttttgcttacctcaccctgattgaagtcagagaagccctcttgaaatggaagggaaatta/g /ARFIP1/ADP-ribosylation factor interacting protein 1 (arfaptin 1) 4247/6/rs9456484/160311179/[t/c]/gcggattattctagtggatcttgctctgggaaccatgattgtataac ccatcagtcccat[c/t]gagggctgttcacctcgcgcaactgctagcagtccagggcctggggaacttcgaatttca/c /IGF2R/insulin-like growth factor 2 receptor 4248/6/rs6917747/160322695/[a/g]/cctcacaatgaccttgtaggctagctgagttttgtcgaggaagttga gctgggagagact[g/a]gctcacacagcttgttagtcagcgctggggcaggaatctggcccaggcccttcatggcac/g 40 /IGF2R/insulin-like growth factor 2 receptor/ 4249/8/rs2245642/18478478/[g/t]/actagaggtagcatgactacaaaacccctctggccttataattacgct ataacagaaccc[g/t]gcacatgtggctctccacgcagtgtaacttagattccagacaaaaacatgaggtaggtaa/t/ PSD3/pleckstrin and Sec7 domain containing 3/ 4250/8/rs6983527/18504346/[a/g]/cacatggatgaaacaacctataatcctcccaaaaagataactagggag caattattcaac[a/g]gtatttagttggtgtgctataaaagcactgctctaagtgctctgacacttattaatccat/g/ PSD3/pleckstrin and Sec7 domain containing 3/ 4251/8/rs3757934/32728334/[t/g]/acattgcatccttcaggaaaatcagaccttaaaggtcaagtacaactc agaaaggtaagg[g/t]ctctgtttcttggccaggccagatcagactgaaaaatgtgcttgatctggaaacatgtta/g/ NRG1/neuregulin 1/ 50 (300) JP 2010-88432 A 2010.4.22 4252/8/rs1373796/123873449/[g/a]/gatataacttacatacccaagtgtcacccactttaagtgtacaattt attgacttttagt[g/a]tatttacaaaattatgcaaccattaccacaatgtgactttagaacatttttatcacccca/a /ZHX2/zinc fingers and homeoboxes 2/ 4253/9/rs10971712/33810938/[t/c]/ctgtatttcacagaatttttttattcatcctgctttcgcttatttaa tatcgccaatcca[c/t]gtgattcttagttttgggccatatagatgtaggatgggcaaagatagtttcttctgtcca/c /UBE2R2/ubiquitin-conjugating enzyme E2R 2/ 4254/9/rs10971750/33859781/[c/t]/tacaggtgtgagccaccgtgcctggccgggacataatgttttttaat gactttttgctta[t/c]gcattttagggtacatctttgcctagatattttttatttttaaattattttttgttttgt/t /UBE2R2/ubiquitin-conjugating enzyme E2R 2/ 4255/9/rs7856487/33860940/[a/g]/tttctttctcctcaatcccaatattaaatcaattacagagtctcattg 10 actatacttcct[g/a]tgtgtctcaaaaatacgttttgtgtttattccaactgcctctgtctttgctcacatgtgt/g/ UBE2R2/ubiquitin-conjugating enzyme E2R 2/ 4256/9/rs10971773/33888779/[a/g]/aatcactgcactacagcctaggtaacatagtgagactcccatctcta aagacagaaagaa[g/a]ttaaataaataaataaatcttaccttccatgttaggctaagtccaagagataagtcactg/g /UBE2R2/ubiquitin-conjugating enzyme E2R 2/ 4257/9/rs2799466/125587911/[c/t]/atcagctcttaggccgaatagtctaaagagattgagagtttatacct gcagatgaaaaaa[t/c]tacatttccacctacgtttccagactgccaagttactaagaaatacggaaagtgagcctt/t /DENND1A/DENN/MADD domain containing 1A 4258/10/rs734210/28728684/[g/a]/aatgtgatgtagtgatcggttgtgatctactcatcttttgttgccttt gcaaacttcagc[a/g]ttaatgaacaccctgagatgttactctagaagcatctgacttggaggatcctgattaacg/a/ 20 RPSAP10/ribosomal protein SA pseudogene 10/ 4259/11/rs481855/100474570/[c/t]/agtctggaaaaaaaggtaggtaaatctctataagccagaaaagaaaa aagaaatgaaagc[t/c]ggaggaacaaacttaactggactctgcagtgatccaaaaaagtttcagatacagatataa/c /PGR/progesterone receptor/ 4260/13/rs6650282/94546222/[c/t]/cagagtactcaatagaaaaattgttaagacacttaaataggtgctta cccaaatgatatt[t/c]aattggtcaataaacataaaaagatgaaaagtataagagcaaaacaaatgaaaattctat/c /ABCC4/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 4" 4261/14/rs4901055/50296750/[g/a]/ttcagcaatttcatttttaaggtcacttatttgtttttctaaggtgt gcgtttcgttctc[a/g]tgcctttgcttcatgttctcctgtgccttcttgcagctgaccacggtttcgtccagctgc/a /NIN/ninein (GSK3B interacting protein)/ 30 4262/14/rs7153562/50301048/[c/a]/acgtgcgcacaaattttcatagctgcgttactcataatagccaaaat cccccaaatgtcc[c/a]ttaaccggtgaattaataaacaaaatgtggtatatctacgcaatggaatattattcaaga/a /NIN/ninein (GSK3B interacting protein)/ 4263/22/rs4820378/38199155/[c/t]/cggggaggcctcagatgtgctgtcctctcattcccctccttagtcct gtgtgtgctgcta[c/t]cacagaatacctgagactgggtggtctgtaaacagcagaactttctcacggatctggagg/t /MGAT3/"mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransfera se"/ 4264/3/rs9854418/187759087/[c/t]/agcagaaactgtagcgtgtccactgaaagctgtccaagaagaaaata aaagatgaataga[c/t]gttttaaaacatcaaccactagtctaacaactaagtagacatagtaaattcacaagttgg/t /TBCCD1/TBCC domain containing 1 40 4265/14/rs10144553/72270600/[t/c]/ccataggaccaccactgtgctgggactagggacataggaggtgaac caaataaagacagg[c/t]cctgcctttaggaggcttacagtccaaagagacagatagtaaatgcaaaatacaaaatca/ c/DPF3/"D4, zinc and double PHD fingers, family 3" 4266/12/rs964841/60572303/[t/c]/ctgtcttctcaaacttaatatgttccaaagacaattaactcatttcca ctttctctccat[t/c]gtagtaatgacaccaatattcatctagttttttaaaccaaatatcttgactatgtccttg/c/ FAM19A2/"family with sequence similarity 19 (chemokine (C-C motif)-like), member A2" 4267/4/rs11097197/89911004/[t/c]/aagctttgcaaaaagcagttgtgagatgtgagaaagcttagctgatc tccagtgttaaaa[c/t]aagtattaacttcttcaactccatccctaccactttttacatgttttatccatatgttta/c /FAM13A1/"family with sequence similarity 13, member A1" 50 (301) JP 2010-88432 A 2010.4.22 4268/1/rs6428904/243430046/[g/a]/attcacgagattgttctaacacccacaaggaatgcacactctcgtta atcccacacgact[a/g]tttctttagtggcttatttgtgtttaatttccaagataggggcggtgatattcccaaatc/g /KIF26B/kinesin family member 26B 4269/6/rs11756544/15505420/[c/t]/tattactatactgctgtcacagagtgcccacactttaatgatgtttt tgaaagtcaaata[c/t]tagcacagtagatcccctttctgcattaatttttatcacaccctatgtgatatggtcaat/c /JARID2/"jumonji, AT rich interactive domain 2" 4270/4/rs3733526/120747775/[g/a]/atgggtctaagaggccggtcaaattcagaggcagagattttcctggt tggtgttccaggg[a/g]cactgttatctgcacgaggactctgctgcaagggacaagagcaagattcggtgtggcctc/a /PDE5A/phosphodiesterase 5A 4271/9/rs4744381/96640910/[c/t]/gatccacaaatatgtttctccatttatttagaggttctattgtttttc 10 tcatcagtgttt[t/c]gtaatttacaacatagaggtcctgtatgtattttaccagattgatacctaagtatttcac/t/ C9orf3/chromosome 9 open reading frame 3 4272/2/rs4241120/112569189/[g/a]/atagccttagcctttctcctgtggcccttcctcccctttttttcttc ttgtttctctttc[a/g]tttctcttttcttttctttctttctttttttttttttttttttttttttttttttttttt/a /TMEM87B/transmembrane protein 87B 4273/10/rs10491052/108384604/[a/c]/ataatcagtagtcaggaaagtcttgtgtataattaattgaaaaat acttcaatctaataa[c/a]tcaaaagaaatcatttctgaaactaaatccaggctggcaaacatctagactattataaaa /a/SORCS1/sortilin-related VPS10 domain containing receptor 1 4274/18/rs321663/8626000/[g/a]/ataaaaatcctgaaggtgatgccgggaccttccagtcaaatcagttgcc taagtttctaa[a/g]agtgtaacatatctgacatttaaatgtgaatagcatcgtttctccatgattcaatcctta/a/R 20 AB12/RAB12 4275/17/rs6608/7405137/[t/c]/ggagctccgaattcttgcgtgtgtgtagatgaggggcgggggacgggcgcc aggcattgt[c/t]cagacctggtcggggcccactggaagcatccagaacagcaccaccatctagcggccgctc/c/TNF SF13/"tumor necrosis factor (ligand) superfamily, member 13" 4276/13/rs9301921/93432990/[g/a]/aatggcttaaatgagatggaacagattttctcagctggtgggtcata aaatgaactgtta[a/g]tcagaatctgtaacactagtttttccgtcagcatcacctctcctgccaaatggtattgag/a /GPC6/glypican 6 4277/7/rs10250570/146704296/[a/g]/actcggtagtgagagcacagagggcagtcccagtgttcagagagtt tatggcagatagtc[a/g]aaggagagaaatgaggaacaaggaagtataactgtgtgacaggagactatcatacaactt/ g/CNTNAP2/contactin associated protein-like 2 30 4278/4/rs7693781/187058887/[a/g]/aaaatgtgtgattagatgagttggaagaaactgcctacaatttactg aaatactttgtgt[a/g]tatgtacgtatgagtgggagagagagagggagggagagggagacagggaaacagagagag/g /SORBS2/sorbin and SH3 domain containing 2 4279/1/rs10917275/19448622/[c/t]/ggctgtaccatatagcctaggtgtgtagtaggctaaaccatctagat ttacataagtaca[t/c]gctacaacgtttgcacaagagggcatttctcaggatgtattcccatcattaagtgatgca/t /KIAA0090/KIAA0090 4280/11/rs3741355/3084956/[a/g]/gttccggaagcagaggtagccatgcctcatcctagggggagcacgcag ggcccagggggt[g/a]gcttttgtccccatcacttggcagtgagtccaggagctgtcttttaggtaaacaggctcc/a/ OSBPL5/oxysterol binding protein-like 5/ 4281/15/rs8024732/40358010/[a/g]/tctgcatactccgtatctataggcgtcagaaacagtggctttccaag 40 aagtccacctatc[a/g]ggcattattggattcagtcacaacagatgaagacagcaccaggttccaaatcatcaatga/a /GANC/"glucosidase, alpha; neutral C"/ 4282/15/rs11070370/40364832/[g/a]/taggactcagtacagggaaggcaggggactctaaggtgggacactg agccattccccact[g/a]tctttaacccaagtggctttacttattggacttctgggagtctgctgatatttaaaagaa/ g/GANC/"glucosidase, alpha; neutral C"/ 4283/16/rs6564438/75968688/[c/t]/acaggctttagatttaacagaaaaagggagactgcagcctccagatg taactgacaaatt[c/t]agtgttaggatgagtgcacaattaatttttaatagttcagtgtgaagagctttaaagatc/t /ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 4284/1/rs995634/223371594/[t/g]/ggtattatcaacattgctttcccatacttctgactttctgctcttatt tccctataggtg[t/g]ggttatcactttatagactaagttaccatatcacagataactttacattcactgtataga/g/ 50 (302) JP 2010-88432 A 2010.4.22 RP11-328N1.1/similar to CG7092-PA/ 4285/5/rs159030/94238376/[g/t]/tcatgtcctctaaactgtgcatgccttgagagctggactatgtcttaat catacttataa[t/g]tctggggtgagcagagcagccactcgataagtaatgaatgcttcaaaaagcattcctatt/t/M CTP1/"multiple C2 domains, transmembrane 1"/ 4286/1/rs650112/223485079/[g/a]/ttgccccactttatgagggccgatttattgtttagcttgtaatgagta ccatatttggtc[a/g]tagtcacttgaatgtttcaaagtttacattttggaacaatcagtcttattttaaaaagga/a/ DNAH14/"dynein, axonemal, heavy chain 14"/ 4287/16/rs17248982/60344326/[a/c]/aaataacaataactataaattagatcaaactgccttctctgaaagc ccacttacttacag[c/a]aacatagacagctttctaagggaggtaatgatctggaccttgaaggaaaagtagtatgtg/ a/CDH8/cadherin 8/ 10 4288/11/rs353646/35148690/[t/c]/tctcctgcatcatgtaatgaataaaatgtcccaagtgcctccctctga gcgataaatgag[c/t]tcaactgaaaacactgactgtttgaggccacttttggatttggagaggagacttcccgtg/t/ CD44/CD44 molecule (Indian blood group)/ 4289/11/rs353630/35144767/[t/c]/tgcaaggcaccccaacgtcttggcgcctggctggaccccctgatttct ctgccttttttc[c/t]gtggagcctggagcctgtcatggcagtcaacgctgaaccaacatggaggggcctgtcaca/t/ CD44/CD44 molecule (Indian blood group)/ 4290/18/rs1785933/31973189/[g/a]/caaaatgtcattattcgggatgtgaaggagctatcattttgagagaa atgctcatatgcc[a/g]tcttcattcaacactttttcaacttaccccagaccttcaccttctaaagaattagattct/g /ELP2/elongation protein 2 homolog (S. cerevisiae)/ 4291/1/rs11208199/63615560/[g/a]/tagaatttttttgtgtgtgacctgaatttcatatcactgttgcttcc 20 ctgtttgtttaca[g/a]taatgcttttttgttaaagtttgtttcctctaaaattaatatagccataatagttttctt/a /ALG6/"asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-gluco syltransferase)"/ 4292/13/rs1220597/23716013/[c/t]/agaaaactggggggttagcttattgtatttatatacatcttcaaaaa acttttggtatgc[t/c]cagagtccctatgctttaattttcttctgaattaccttgctgtatgagtttcccagggtt/t /SPATA13/spermatogenesis associated 13/ 4293/21/rs2269160/43048665/[t/g]/gcggccagtcccaggggctgcactgctgcaaacctgctcaaaacctc cagccgccacgtg[g/t]caacttgctccccagctctgagagtgcaggaccggggcgcagagacgacagaagaggctt/g /PDE9A/phosphodiesterase 9A/ 4294/9/rs1475508/396117/[g/a]/ttaatgaaatataaagtgtgctcccaggatacaaatacaggacaggaatt 30 actgaggacc[g/a]gtaaatctaatacttccctccctgacatcacttgtagttccaggccagcaaaagtctgac/a/DO CK8/dedicator of cytokinesis 8/ 4295/7/rs10954664/81613491/[c/t]/agatactcatgtactacagcccagagctgaactatcatgctggtgac acaaatggaaata[c/t]ctccctagaagaaagaaacattcatgacgttcactaaaaggaactgctcatttcttctac/t /CACNA2D1/"calcium channel, voltage-dependent, alpha 2"/delta subunit 1 4296/7/rs10488616/37899584/[g/t]/ttgttgtttttagaggaaagtccagatttcttcacagggcatagctc ttgataatccttc[t/g]tctacttacttggccaacttcatctccagtatattttcacccagtcacttcttcctgccc/g /TXNDC3/thioredoxin domain containing 3 (spermatozoa) 4297/1/rs783622/42139575/[t/c]/atctcatctggacccctctttggaagaactgattgtaaatgcagccccc ttcttagcatc[c/t]ccacttagatgactcaacacacgcataactcggctcagcaccttcccacatgcatgacca/t/H 40 IVEP3/human immunodeficiency virus type I enhancer binding protein 3 4298/3/rs9880413/123832505/[g/a]/aaactcacccagaagtggtgttatatgtgttcaatgtcatatggctg gtcacaggttgag[g/a]ctgatctgttcttctgattccaagtcctgatagcttcctgctttccagcctcagggcatg/a /PARP15/"poly (ADP-ribose) polymerase family, member 15" 4299/3/rs1106346/123836727/[t/c]/aagtctgagactattgtttgccttattctgatcagccaaattacttg cttccttaccatt[c/t]ttcccagcacaacttctattaaagccgtgctgattgacatatggcactgagtctgcatct/c /PARP15/"poly (ADP-ribose) polymerase family, member 15" 4300/3/rs12489170/123837482/[g/a]/gacagcaatgggagaaagcacatgtacgttgtgcgagtacttactg gagtcttcacaaag[a/g]gacgtgcaggattagtcacccctccacccaagaatcctcacaatcccacagatctctttg/ a/PARP15/"poly (ADP-ribose) polymerase family, member 15" 50 (303) JP 2010-88432 A 2010.4.22 4301/4/rs4235326/24618589/[c/t]/ctttggcaacatggtcaccaggcctgcaaaggaggaagtgcatggatt gagaaaatcctg[c/t]cctgcccttgtcaacttggggaccaccccatggccaaacaagatgtcaaatgaggtgtgc/t/ LGI2/"leucine-rich repeat LGI family, member 2" 4302/7/rs3750170/69871075/[a/g]/attgaatgtaactgctttgccatttttgtgctcttgccacagatcagt caatgactagca[a/g]ccttccttaatcatctttgcaagagttcccattgctcctcgccactttggatgcttgctt/g/ AUTS2/autism susceptibility candidate 2 4303/16/rs3785217/7653117/[c/t]/cagagccaccctctgccaaggtctgatgaaagagagggagcaacagat atttagtttggg[t/c]cccaaaccacaggactgatcacttagccatatcaaaaccgctccatcccattctttcatg/t/ A2BP1/ataxin 2-binding protein 1 4304/1/rs11576197/190936860/[g/a]/ctctgggtaaggcaactattctctgtgccacaaaaaaagtgtttta 10 ttcagttttttctg[g/a]aggaaataaggctaatgctgttttctatggagaaaagcataatttccaaattaatgatta/ g/LOC388720/similar to ubiquitin and ribosomal protein S27a precursor 4305/2/rs3748985/2139612/[c/t]/atatttttcctcagtctccctcgagacctccccgatgatcctgctgtct cagcagggctc[t/c]ccaacagccgctttgctctgttcccaagatgacagctcttgctcagcactgggagggacc/c/M YT1L/myelin transcription factor 1-like 4306/4/rs6831604/40755806/[g/a]/taaagctctgaagatgtaaaaggctatcagaacatgagacaggcttag tgtgtaggggct[g/a]agatcctgatgaaccctggagaacaaagggtcatatctcaccaacaagaaatcaaaattt/g/ APBB2/"amyloid beta (A4) precursor protein-binding, family B, member 2" 4307/7/rs995596/95343497/[t/c]/aaacaggggaatttatttccacataggagcattt[c/t]ggaagaagag acaaagtttcagatatatctggattttcactttctgggggaagcattagg/t/DYNC1I1/"dynein, cytoplasmi 20 c 1, intermediate chain 1" 4308/16/rs8046202/56483672/[g/a]/ctgctctgggcatgtccttgaatgaccacaaaagcctgttagtattg atcttggcgttgc[a/g]agtccatttcagtgaggaggcgaatttgcaaatatggagtccatgaatcacaagggtcca/g /CNGB1/cyclic nucleotide gated channel beta 1 4309/15/rs4129470/96800150/[c/t]/acgtgctgcgctcagcatgcgacaccgtgccacagtgaggaagtatt tccctaagttaat[c/t]gttgacagttcctaaacgtttcagaagcttactcgttaaaactaatgtggtttctgtttc/t /FLJ39743/hypothetical protein FLJ39743 4310/18/rs2287500/8776354/[a/g]/gctcgtcagacagagggacagctcactgtaggcactgtccacctcctg tttccgcagacc[g/a]ggagcacctggaagtaggctgattggtgagtgcgcagtggcttcttgtccagtcgcagag/g/ KIAA0802/KIAA0802 30 4311/3/rs9856967/33623719/[a/g]/taggttatgacaaaaaaagaatactgatgattacatgtcagtggcaac atgtaggaggct[g/a]ttagatgtctaatacagatgtaatggagaaaaaacaatcttaattttactggagggctag/g/ CLASP2/cytoplasmic linker associated protein 2 4312/9/rs2039331/8978375/[a/g]/aaagccaggatttcttacggtttttcttaaagaaaaatagccctaatag atgtcactgca[a/g]caattgatgggagttaaagaaacagattaattggactccatatttctttatttaaacatc/a/P TPRD/"protein tyrosine phosphatase, receptor type, D" 4313/7/rs1639304/83017558/[g/a]/tcactgggtgccacacacatgcacaggaattcagaagttagcttactg gaaatggataga[a/g]taaccattgtaagatcataacaatttgattagttcttcaaaacaaggatttggatcaaca/g/ SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E" 40 4314/7/rs1693389/83014198/[c/t]/cattttcaaatgtcaccattcttgctttataatcagacattaggcttg cttaatttcatc[c/t]taaatttgtcatgcactttttgtttaaacaagtttgagtaaggtatcttcatcaataaaa/c/ SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E" 4315/21/rs914187/41541619/[t/c]/ctaaaattatcctctgatttcattcggtgcctgcgtcaggagggagaa acatgggaaggt[c/t]gtttgtcttgggcagggaaagcatcacaagggcgcgttgtgtgtctggcttaccgtctct/c/ BACE2/beta-site APP-cleaving enzyme 2 4316/8/rs1478023/14072885/[a/g]/cataccttccataaattatacagtaacatttttgacattaaca[a/g] 50 (304) JP 2010-88432 A 2010.4.22 ctgccaaaatgaatttagcgaatgtgagattaccagaagacactaggattattatccttt/a/SGCZ/sarcoglycan zeta 4317/7/rs929346/80300840/[t/c]/tcaactatcagtaagccataggtaattaaatttgaagatgctttatggc t[c/t]ggaaaactagataaaaatccctggaccagaaaggtcttaagttgatgtagctattgctcc/t/SEMA3C/"sem a domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C" 4318/3/rs1532590/33518632/[g/a]/cagatgtaaaacttaatcgggcctggattatgtgactaccttgagcta ccaaaccaatga[g/a]tttaggttttatcggatagtgaggagtgctgactgccttaaaacctaatgctttaggaaa/a/ CLASP2/cytoplasmic linker associated protein 2 4319/3/rs2878373/33529661/[t/c]/attcaaccgtgtttggtagtggtacatctatggcatttcactgaaagt 10 ttaaaaatgata[t/c]ctaatatttgtagtttagttatctaccttttgacccaaataaggcctgtagcatccctac/c/ CLASP2/cytoplasmic linker associated protein 2 4320/3/rs4679072/33549244/[c/t]/attttttgtaattattagttttttagagacagaatctcatttgttgtc cagtctttagta[t/c]gggactcttcacaggcatcatcatagtatactgtagccttgaactccaagcctcaaagga/t/ CLASP2/cytoplasmic linker associated protein 2 4321/12/rs7965541/100644420/[a/c]/tgaagttaggggaatctatgagtgaaggaaatccccctgtgcagga ggctagtataccat[c/a]aataaggttatatttgaatataaaacataaaccctgtagatttcattgtgtcttatttca/ c/CHPT1/choline phosphotransferase 1 4322/11/rs680485/99007288/[t/c]/cagtttgttaagtaccctgaaagtgcactctgtattttactaatgcta ttactatacagg[c/t]tgatattacactgtacataaatggctcattatatgggtctgaaacacatcaaagttattt/t/ 20 CNTN5/contactin 5 4323/9/rs2756900/27193625/[c/t]/ccactaaccccaaccccaggaaaagtatgtgatttgagctagatagag atcctctctgga[c/t]gccatactgtgcccaccatttgtgattgataaagtctgttgagtgtaattaagtgagcaa/t/ TEK/TEK tyrosine kinase 4324/13/rs401709/112501031/[c/t]/ttaaaaaataagtatagttgatattctaagacaggagagaaaatagt cacatcaaatgct[t/c]aattaaaacccaagatggcaggaaaagagtataagtcacaaaagaaacaaagactatgaa/t /ATP11A/"ATPase, class VI, type 11A" 4325/12/rs7300416/97678033/[a/g]/tctgtatatatgcatagaaaatagcaatatggatcaaatgtgaatag tagttatcactgc[g/a]tattgagactggatgatttctatttttgtattttggaactttatttaaatgaggattaat/g /ANKS1B/ankyrin repeat and sterile alpha motif domain containing 1B 30 4326/8/rs10107611/3937950/[g/t]/ctgtgtggggagtatcttatacatagcgggggtcaaagaaaagaccac tgaggaatgctg[g/t]gaacatttttgtgacttgttggttattgcatagtttgaacaagttgtgttctgaatattt/g/ CSMD1/CUB and Sushi multiple domains 1 4327/9/rs7029148/845091/[g/a]/tgctgcgattacaggggtgagccaccatgcccggccagggactgatggct ttgatagcct[a/g]ttttagatagtgtctcaattttgtttatctcagggatagtctttgcttatatgtcaagta/g/DM RT1/doublesex and mab-3 related transcription factor 1 4328/7/rs2270294/38423669/[g/t]/tatcacatgcaagttccctaataaaggcacgtctccagctgtcacagg tagaacaaagca[g/t]taacaggtctgattactcgcaagttctacaacccttctactgtgctatacctgtggctat/g/ AMPH/amphiphysin 4329/8/rs890534/14186652/[c/t]/caatcaatgtgttttccttaatttggaattttttttaatactagagtgc 40 atatttggtcc[t/c]aagttactgttgaaattgttgtgtacatctttactattttcactaatagaatattcatta/c/S GCZ/sarcoglycan zeta 4330/12/rs1512735/84240895/[t/c]/tctgaaatggctccatttatgtgaggcttgagaaaggaaagaggcct cttgtgaactttt[c/t]aaccacagagaggagtgttctctaaaaagatatattcagagtgctataacaagtgctaca/t /LOC727999/hypothetical protein LOC727999 4331/8/rs1003299/17314004/[a/g]/tttcatgattgtgaagcgacaacttaattccctagtgcaaaatcaata caatttaaattt[a/g]ctgtcggaactgacattctccagcaaactaaaagatttcttcttccaatgacatgagatc/a/ MTMR7/myotubularin related protein 7 4332/3/rs9880228/168706556/[a/c]/cactgtcatagacttcaaccttaacagctacaagttatgtttccaaa aattgttattagt[a/c]tcttcagagcaccaagccagaaaacacatccatcgtctcaaaatcgtggagagtcctggg/a 50 (305) JP 2010-88432 A 2010.4.22 /WDR49/WD repeat domain 49 4333/4/rs756359/189579217/[a/g]/caaacagtaatggagatgtaaattaaatactatcttcaaaaggagcca tgaggaagggga[g/a]tgaggtgacaagaaatacaggaaaagcaaggcacatagaagtttcagtaatactcataac/g/ LOC401164/hypothetical gene supported by AY494056 4334/9/rs487750/137743561/[g/a]/gatgcctgttcccttataggaagagtgtgaagatgtaaccagacagca tgcctgaggcac[a/g]cggaacagggcctgcaggtgagtgcttcagctacagcaggtgtagggtggccagcagttt/a/ KCNT1/"potassium channel, subfamily T, member 1" 4335/18/rs276926/26875276/[g/a]/gtaaactgaaaagctgaaaatgcttttaaatatattacaaaagaacac attctctaagcc[a/g]tttccatttgtagtcacttcataagctcagatactttgttggaacagttcccgggcaaat/g/ DSC3/desmocollin 3 10 4336/16/rs4787747/25650052/[g/t]/acatgactgatcttagctatcagtcttcagcctcctgccattggagg tcagattgaaatg[t/g]catggcccagggccctacatgaacaaaaacagctgttcactgcatatcacattgttagca/g /HS3ST4/heparan sulfate (glucosamine) 3-O-sulfotransferase 4 4337/14/rs7159824/54842289/[t/c]/actgaattagctcaatagcaggatttttcccgatctgaattttatcc cccacatttctcc[c/t]ggttactgcaagtactgtatctgtgtataagggtacactgatttggctgtaaagtcatga/c /FBXO34/F-box protein 34 4338/9/rs638203/27193134/[c/t]/acaggcctgtcctgataaaccagctgcctatagggctgcacggtaatcc tatgtaaatac[c/t]tgtccattcaaccaaccttgagattctgggagggtcaccagttcatgagaaaaggctggg/t/T EK/TEK tyrosine kinase 4339/4/rs3846232/4297960/[g/a]/ctgtgttagagtggaggtgaaggtccacagtgggaggagtgacagcttt 20 gtggccagacc[a/g]gatgtccagtagttcctcattcacagggactgagatcctttcagtatagtctccagagtt/a/T MEM128/transmembrane protein 128 4340/2/rs3770841/36569193/[g/a]/ctgatcaacttaaactcaaaatatttataaaacaaaatgcatgctttc tggcaaatttca[g/a]aaacatgttacatgtcccgtattgctcaaagcacatcaaatttagattaaactgatggta/a/ CRIM1/cysteine rich transmembrane BMP regulator 1 (chordin-like) 4341/18/rs10084072/68598219/[t/c]/tgttctcacctggtggaaagggcaaggctgctctctgggccctctt tatcattagaggac[c/t]aacacctatgatgagagctgtacttatgagctaatcacctctcaaatgcctcacctcctt/ c/NETO1/neuropilin (NRP) and tolloid (TLL)-like 1 4342/10/rs915349/84467878/[c/t]/gctgaagggagaaagggagatatttgagttgaagaaattagggtaaag ccagtgggtgta[t/c]cagataggagctagcagactagtatatgtggatctcgtcctctttatttttattttttta/t/ 30 NRG3/neuregulin 3 4343/10/rs2050458/84474196/[g/a]/cctcattcaacagcataattttccctatttctcccaggatattgtac aatcaactaacag[a/g]gtgcagcatttctgccggctaaaggaagtgggcagctttgatcagaattcacaataatat/a /NRG3/neuregulin 3 4344/11/rs485642/95617867/[g/a]/ttatacatccatactgaactgtagaaacaatgaataatacaagcaaaa ccaaaaaagcca[a/g]tgcaactgatatcaacaagaaattcaatactcctctgacatacaaaatataatactcagt/a/ MAML2/mastermind-like 2 (Drosophila)/ 4345/16/rs17770042/75903312/[c/t]/tgaatctattggtagaatgagtgcataaagaaagattttggaaaac aatagccaggcaaa[c/t]atgaccttattccactgtggtgaaacgacaattttgtattactggagatattgctgtagt/ t/ADAMTS18/"ADAM metallopeptidase with thrombospondin type 1 motif, 18"/ 40 4346/21/rs2839616/43298468/[c/t]/ctcggctctcctccccacctcgaggacttcggtggcaaggatcaggc tccggaaaactca[c/t]tggagccatgctggtgaggtctgaggaggggttaggagctgaggcgctgggtcccccttt/t /PKNOX1/PBX/knotted 1 homeobox 1 4347/4/rs4343763/187038584/[t/c]/aactacattgattccttgaaaaaagccatcttattaaaacaaaacaa ggaatattatgcc[c/t]tgttgaagctgacctatcaaaatgtaaaagaaataaagtaatgaatggtgtcttggaaaa/c /SORBS2/sorbin and SH3 domain containing 2/ 4348/6/rs820089/35132673/[a/g]/gaaccctgatactgaccagtcaaaataaacagtgattccattttggtcc aagctgaagac[a/g]gtactccctgagatcctggggaaagccccctcctgacccatcagacagggttcatgggca/g/A NKS1A/ankyrin repeat and sterile alpha motif domain containing 1A/ 4349/9/rs870272/123993381/[t/c]/ctgcagccactcccacactcacgcacacatctcttca[c/t]gcttat 50 (306) JP 2010-88432 A 2010.4.22 gctggtgtgagagcagttggatgggaatacacacacacctgtgtctgtgcacac/t/C9orf18/chromosome 9 op en reading frame 18/ 4350/16/rs6497910/25917161/[t/c]/tcgaaaaaaatatataatattcttataaaactgagcactgtatcaaa gtacatttggata[c/t]ggtagtgcagagagagattatcatcttaattctagatagtatacttctgttactaaggat/t /HS3ST4/heparan sulfate (glucosamine) 3-O-sulfotransferase 4/ 4351/10/rs3998531/73010773/[t/c]/ctgtccccaggggagcaggtggacagcaggctaggatttggcctcat ctctacttccttc[c/t]accagtgtagacgtggctgaaaagaacattgtctgccaagggtctgtctcacacacctgc/t /CDH23/cadherin-like 23/ 4352/7/rs7805063/116828305/[t/c]/ttctggaagcaaacagacctgtaccaaagttttatataatatccagc attcaaccaaaag[c/t]taccaggcatcgtaaattgtagaactaagaaacaagattaatgaaatcgaaaagctaata/c 10 /ASZ1/ankyrin repeat/ 4353/7/rs2191883/35239816/[c/t]/aaggggaaaatatttttttgtttgaaataaattataaacatcctctaa agcccaggcaat[t/c]gatacagtctacgattacaaatatcaacaagatttttaaatcctccaggacatgagctat/t/ TBX20/T-box 20/ 4354/12/rs10845827/13750331/[g/a]/gtgcttcaaggaggcagtaaacaattctctaccttggcaggctttg gtaatcatctagct[a/g]tgccaccaagacctctagaggtcccctccacctatttgatttgatgagtctcttacagtg/ g/GRIN2B/"glutamate receptor, ionotropic, N-methyl D-aspartate 2B"/ 4355/10/rs10509267/67947835/[t/g]/ctcatgtaaaggttacttaaataacaaaaacccttccttatctcat atacctagatgttt[g/t]atatacttggctttagggttactagccctagcaaacggaggacttgggtaggagcagtta/ t/CTNNA3/"catenin (cadherin-associated protein), alpha 3"/ 20 4356/8/rs800907/116498839/[a/g]/caaaaatttatttccctgtgcctttttcatttcgtttggcgttttacc atagctcttagc[a/g]caagccagtgaatacattatggctacagggaatacacttttagacaaaatgttctcatat/g/ TRPS1/trichorhinophalangeal syndrome I/ 4357/4/rs4132266/144305695/[g/a]/tctctcaccctcctgattcaatctaacaaatattaagagtgctatct ttaaactgtattt[g/a]gaatcttaacacttctttccacctccactgttaataaccctggtccaagccacaaccaac/a /LOC729675/hypothetical protein LOC729675/ 4358/1/rs3766178/1468043/[a/g]/tgtggctgctgaagcgccagggacggtcttcatgatcgcctggcaggag aaaaggtcata[a/g]gaaaatgtcgtcccagaagttattgcacgatttctgcttgggtcacgttggccagagctg/g/S SU72/SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)/ 4359/3/rs1372555/19346584/[a/c]/ttgaattctttagcctattatgcaagatctctaataaattttgctgaa 30 agtttactctca[a/c]ttttgtctcccgcagcatccattacacaccaccacgcataatgtgtgtaatatttttctc/a/ KCNH8/"potassium voltage-gated channel, subfamily H (eag-related), member 8"/ 4360/9/rs2593396/17407026/[c/a]/atgcagttaaggtttgggtataaggctactctgggaataaagtcagaa cacaattcttaa[a/c]tggcataacactaatccttcaccattaaagtgtttatatgtattgtttgaatcaaagcac/c/ C9orf39/chromosome 9 open reading frame 39/ 4361/2/rs1474406/141516543/[g/a]/gaactgtgaaagcactgagattttattatgtttgtaaactaaaacat tagcctgctacac[a/g]ttcatggatgctggcaggagacatgaaacttcagagacaaagtacagtttattactaaga/a /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)/ 4362/5/rs12520862/76556268/[t/g]/atattatcaaatacaagacagtgttgaagtttccctatctcataaac attttcatttaaa[g/t]atttttttaatcatctttcaaataagatctagctattgcaatcaattgatatgtttctta/g 40 /PDE8B/phosphodiesterase 8B/ 4363/8/rs800897/116491112/[t/g]/cagcaggcaactgcaaatgagaagaagatagaaggacgcccgtcggga ctttggagggca[t/g]tgttattttcccaaagaaagacggccaagggcagaggcatggattctttgcagagcactt/g/ TRPS1/trichorhinophalangeal syndrome I/ 4364/8/rs11136286/144173868/[c/t]/acctttgtccagctgtgccctgctccactccctctccacccctctc ccctgagcagacgc[c/t]ccaggggtccttccaggccgctcccagcagagggctcacccggcctggccacactgtctc/ t/LY6E/"lymphocyte antigen 6 complex, locus E"/ 4365/13/rs8000417/93396157/[c/t]/tgttgatatttttgtttttgttaatgggtagcaacaagatgttggaa tttcatttgttca[c/t]caatgatatcagtcactactgaattgcataatagatgtcaaaatactcgacgttttttct/t /GPC6/glypican 6/ 50 (307) JP 2010-88432 A 2010.4.22 4366/20/rs725466/19984075/[c/t]/cagagaattaaaaattaaaccatgcatctacctgggactttggatggg cccctcggtaag[c/t]gagggggctagaaaaattaaactcaccagcccaagaaagtgacaagctttctctacacaa/t/ C20orf26/chromosome 20 open reading frame 26/ 4367/13/rs6420299/48868939/[a/g]/gatgctattcctttacctgtattccaaataggattcacagatagaaa gaaatgaaatcaa[g/a]tgtacatggcaaaaaattgtgcctgtaagattcattttttaaaattaaatgggatggagg/a /CAB39L/calcium binding protein 39-like/ 4368/4/rs6837863/37067053/[c/t]/taaaaaggaatttaacataatgcctgctaatactaaaaggtggtgaaa aaaataaaacca[t/c]gagaagggatggaggctggggctgcaatgacagatgatcaagaaacacccctctgagaag/c/ KIAA1239/KIAA1239/ 4369/2/rs1053807/26653926/[a/g]/ctcttccttgattgaaccatagatggtccagcagcatcggaagtacta 10 tcaagacaagac[a/g]ggcacagtgcctcgagtcccctactttgcgatgcccgtgagggagccggaacggtacccc/a/ LOC339778/hypothetical protein LOC339778/ 4370/2/rs754943/142205148/[g/a]/tgcatacataacccaatgataccatgttctgtattatgaaaataaagg aggacccttagc[a/g]aatggtctttgtttggggcagcctcccacttttccaatctgtgccataatctcctgttcc/a/ LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)/ 4371/5/rs2408382/124683833/[a/g]/tctcaccatcatcaatatttgagcattcaggttgctccactatcttg acaacatggtatt[a/g]ccagtattttaaatgtagctattttagagggtgtgaagtggtatcttattgaaggtttaa/g /LOC644659/similar to High mobility group protein 1-like 10 (HMG-1L10)/ 4372/6/rs638393/124470479/[t/c]/caaatatttcagtgtacagtacagtgttgttaactataggcacaacgt tgcatgcagatc[t/c]ctaggacgtattcatcttacataactgaaattttacactcattgaacagcaatctcttat/c/ 20 NKAIN2/Na+/K+ transporting ATPase interacting 2 4373/10/rs2384716/37876934/[t/g]/tggctgccaggctcctgtcagccatgcagtgagaaagctgctttcat ctttgtttggcct[g/t]gatgctggtcctctgccccactctgcacctgacttgctggtcccaagtcccccttgtcag/t /LOC219752/similar to transforming/ 4374/13/rs2875504/42405268/[g/a]/atgtgatcctgaattggatcctgaaatagaaaaggagcactggaggg aaactgatggaat[a/g]tgaataaggtctgtagtttatattaatagtattgtaccaatgttaattttctgattttga/g /EPSTI1/epithelial stromal interaction 1 (breast)/ 4375/14/rs2619671/80169911/[t/c]/tcaaaccaggtcctcaataaataattaaataaatgactacctgtttc tagttaaaataaa[c/t]gtgtgcccatgggaggtgtcccatccattcttggtattaaaaaaatgtgaatccctatgt/t /C14orf145/chromosome 14 open reading frame 145/ 30 4376/22/rs739363/38090829/[g/t]/ccgagtcttttttaaaaacggattccagatggcgcttggtggagatct atgtcaaactca[g/t]aaaaacaaatcagaaggaatctcagaatcttggatttcaggatccttggctactggattc/t/ SYNGR1/synaptogyrin 1 4377/22/rs9614037/28451285/[a/g]/gggatcaagcagcctcctcagcctccctgtctgcttctcggctgctt ggggagtggaaat[g/a]aacgtgtcccctaaccaggattgttcgtgggctctgagtagcggcttcacagcaagcggt/g /CABP7/calcium binding protein 7 4378/15/rs10518997/71343997/[g/a]/tagcaaaaaaattaatgcagcataaagtaaaataagcttgagctat aattattgacctag[a/g]tagatctaagatgcctatgatgttgagtaaaagaagcaagtgagaggtggagaaatgcag/ a/NEO1/neogenin homolog 1 (chicken) 4379/12/rs1370938/64040509/[t/g]/tgaaaaaataaataatttgtaaggccatttttggctcccagcttcta 40 caattcttcccta[t/g]gccttgttgatattcaccttctctgaattcctgtctatgtgatttatgtttcctctaaaa/g /MSRB3/methionine sulfoxide reductase B3 4380/8/rs1507081/59182822/[t/g]/gtataatgcataataataagcgcctctggattatttttaatgcatcag atcctgtgctat[g/t]gtctgtgtaagagaaaggaaccctgattacagttttggagagtgttcctggtgcccccag/g/ FAM110B/"family with sequence similarity 110, member B" 4381/5/rs2967790/137039660/[t/c]/gaaggaagggcatcctctcagtttctgactttaaggcaggaagggtc ctatgcacacaca[c/t]gcattcaaggaagccaaggcctccctgagcctaagggagagtccagtatattgtgccagt/c /KLHL3/kelch-like 3 (Drosophila) 4382/5/rs2967789/137034740/[t/c]/aaatctcttcacagactcctaccccactcccagcctcatttcccacc attctccacggtc[c/t]ttgattcttatcacagagtttacttttctccccaggtacgagctattccaaacttccaag/c 50 (308) JP 2010-88432 A 2010.4.22 /KLHL3/kelch-like 3 (Drosophila) 4383/4/rs3112854/186412560/[a/g]/tgtcattagacaagtttctggttgaatgaggactgtctctttgttct aagagacccaggc[a/g]tggactttcatgatcatggggctgtacctcatgggcaggacatgtatctctgaatcgcat/g /SNX25/sorting nexin 25 4384/3/rs7631150/62450495/[g/t]/tgcaagtaagtaaatgttatttcaagaccattgttattttaaaacgta aatattactcat[t/g]ttaaccttttcctcttaatagctattctccagcacaactgtcttcattgtattgaacatt/t/ CADPS/Ca2+-dependent secretion activator 4385/2/rs11885626/233562641/[g/a]/tgctatgcagcagagaaatgagtctagacagagagaagttagaggc catgatggggaaaa[g/a]taaagctgttttatatgtatactttcaaaaactgtggtttcccaaagaattaggtatgga/ a/NGEF/neuronal guanine nucleotide exchange factor 10 4386/7/rs3779320/77529523/[a/g]/tctctataggccctccccacatgcctccccatgttctgagccactcca ggaacccaccca[a/g]tgtggacacccacctcggataactagagcttctacttagctccagccatgggggcccagg/a/ MAGI2/"membrane associated guanylate kinase, WW and PDZ domain containing 2" 4387/18/rs1313578/26831745/[g/t]/gggtgagcacaaaatgttacaagagcacagaagtagagcattaaaat tcaaatccaaaca[g/t]ggtaggtggaatagaacaggtaactggaaaaactctgagctaagagactagggactagta/g /DSC3/desmocollin 3 4388/1/rs1231918/223560451/[a/g]/tagcaaaatgctgctattgaggttgctgcttatgtaaatgtcaggcc tatacttgcctgc[a/g]gcacacaaattagttcacactctccagcatgagtgctgatgaaatatcacattgccctgg/g /DNAH14/"dynein, axonemal, heavy chain 14" 4389/5/rs2366281/63537289/[c/t]/tggatcatcagcatataagttttaggtgaagctgtgagagtagatgag 20 attaccatgcag[t/c]gtatgaatggagtgagagttaagtagttcctatcatacaggaacatttataggatagaca/c/ RNF180/ring finger protein 180 4390/6/rs820074/35142732/[g/a]/tcccggttcagctgctcaaggttcttaagaaagcaggacctgctaaaca agagtggaacc[a/g]cctgcctcacagggtttgctacccagcatcagcctgagggcaggaatcaggcgctcagtg/a/A NKS1A/ankyrin repeat and sterile alpha motif domain containing 1A 4391/18/rs10503142/64862553/[a/g]/gcttccaaaaacaattaatacaatattctcattttgccacagtaac tttggttcttaacc[g/a]caggaccattgtgcagattaaatgaaagcattgaaaactgtgccaaaggcatagtgtgct/ a/CCDC102B/coiled-coil domain containing 102B 4392/1/rs7542399/216093200/[c/a]/aacatgattattcctgatggtaatatgaacatctaggtttagtagag gatcatgagagta[a/c]tgtttataatgcttcgcttattcattaccttattttttatgtcagtgaaattacacttaa/a 30 /SPATA17/spermatogenesis associated 17/ 4393/4/rs177357/23053543/[a/g]/tgaaagaggtgagattgtctggatcagagtataaggggaaaagtggtgg atgttaaacag[a/g]gccatgccatgaagtagcttatgtgccaagcttaggagtttggacttttgccccaaatgc/a/L OC643751/similar to cell division cycle 42/ 4394/5/rs1445823/13953345/[t/c]/catggcccagatgggtctggaagtctctccactggcaacttccctctt ccagaaacgaga[c/t]agatacaaaaggaacttcagtaacatgaaggtatactacttttattttttccccccattc/c/ DNAH5/"dynein, axonemal, heavy chain 5"/ 4395/10/rs242980/119271233/[t/c]/ttctcttatttctgttaagtaacctgttaaatctcttggatttttcc catttaataactg[c/t]tttacttattatcaaagtaaagcatggctagcatagaaaatgaaaacatacaaaaggaaa/c /EMX2OS/empty spiracles homeobox 2 opposite strand/ 40 4396/2/rs16843022/210090954/[c/t]/cctggtccagcctttgggaaaccagattacattctttcatctcata gtttcatgggcatg[c/t]atttttaccagggaaagagaatttgtacatgataatatttctaaatcatactctaaatca/ t/MAP2/microtubule-associated protein 2/ 4397/9/rs2233568/35947355/[t/c]/gaggatcccctcagctgaggggaggaaaaaggtcttctccacctgctc tgcccacctcac[t/c]gtggtgatcgtcttctacgggaccttattcttcatgtatgggaagcctaagtctaaggac/c/ OR2S2/"olfactory receptor, family 2, subfamily S, member 2"/ 4398/7/rs2535368/82995143/[a/g]/ctaacttattctttttcttggttttcttaaccttagatgtttaagtac tcaattacttta[g/a]gcagaaaacaggttttaaatataatcactgtgtaaatatttttatattaattgccacaaa/a/ SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E"/ 50 (309) JP 2010-88432 A 2010.4.22 4399/1/rs7530353/218177944/[c/t]/atttctgtaatgtttgttatcttttccctagccaccggagttctgac agttcatgttcat[t/c]gttttatctgaaaatttcttctgtcacctggggtaattattatttttcttcaatgtattt/c /LOC728528/similar to solute carrier family 30 (zinc transporter)/ 4400/3/rs6439924/141652347/[c/a]/cacaccccttcacccacactgttctaacccaaggaaccaagtaaaaa tatttagaactga[a/c]tgtgaaataaactctgcttgatattgtcatgttccatttttcacgtcaccaggctggcag/c /CLSTN2/calsyntenin 2/ 4401/8/rs2244163/143781502/[c/a]/gcacaaccagcggagcactgcttcgcaaccatgaaaaaacgtggaaa tatttctaatagg[a/c]aataaagaccgagagaaggcaatcacgcaattccaatgcctgacaccgaggcccttctgt/c /LY6K/"lymphocyte antigen 6 complex, locus K"/ 4402/9/rs7031694/71412996/[c/t]/cacagaatcttcttaattacaatgatgaacactgttgactgcaaactc 10 agtcataacata[t/c]agaagtgtttactaaggtggaaatggccacagtgataaactaatgcacccgtaccagatt/c/ APBA1/"amyloid beta (A4) precursor protein-binding, family A, member 1"/ 4403/17/rs4791759/7618652/[a/g]/aatagtgcataatgaatactgtaatgaattaacagagagaatgggttg agcatgttagac[a/g]gtctggggatacttctctgcgtccagaaaccctcatggcagtctgtgccccactgttcaa/a/ DNAH2/"dynein, axonemal, heavy chain 2"/ 4404/1/rs11211328/46853252/[t/c]/ccattcagcaggaacttgttctcttgaaaaaaactcacagatgtgaa aggtcatctcatc[c/t]atcccgactcttcgacttctcacccaaagaagtccccagggtgggaccccagtttccaga/c /MOBKL2C/"MOB1, Mps One Binder kinase activator-like 2C (yeast)"/ 4405/1/rs12029680/46853328/[t/c]/cttctcacccaaagaagtccccagggtgggaccccagtttccagagc aaagagatttctg[c/t]gcttcatttgccatctccattttaaactctgcttggggcaagtgcttccaaaatccctca/c 20 /MOBKL2C/"MOB1, Mps One Binder kinase activator-like 2C (yeast)"/ 4406/4/rs2292433/189575463/[t/c]/aaggctgttgaaatattcgcaaatacaacccagctctagaaatcagg aagtggtgctcta[c/t]ggatatgcaggagggagtgctgaaagaacagctcatgaggtagtgcaggcagaggcaggt/c /LOC401164/hypothetical gene supported by AY494056/ 4407/17/rs12051822/46078584/[a/g]/aaacaggatggtcagggtaggcttcattgagaaagaaagacttcag gatgtctgggggag[g/a]agtgttccaggaagagagaagagcaagtgcaaaggccctgagacaggagcagcaagtgca/ g/ABCC3/"ATP-binding cassette, sub-family C (CFTR"/"MRP), member 3" 4408/21/rs2253861/40187781/[c/t]/ccagggacgctgatttcaggcggttgaaggaggaaggggctgtcctt cttctagactctt[c/t]ggtgagcatccaggaagatgccgtgtctgcatggggacaaggtgttgtggagggtcccaa/c /PCP4/Purkinje cell protein 4/ 30 4409/21/rs2276524/40188764/[a/g]/cttctgtcacgtcatgaaaaagaatcttttcgttggttgcttagaga atgacctacctcc[g/a]tctgtctgttcatttgaccatcaacccatctacccatccgtccacccatttatctactca/a /PCP4/Purkinje cell protein 4/ 4410/4/rs11935545/183551277/[t/c]/aatgagatccatttccatcaccgtctgtgtagcacaccattaaaaa taactaacagacaa[c/t]gtctttttaaatgacacattattttacttaaatctttacatctgaatcctgttcctgctt/ t/ODZ3/"odz, odd Oz"/ten-m homolog 3 (Drosophila) 4411/10/rs11812567/60218282/[a/g]/atgtcagcaacatttgcattataaggcactaaaaatataataattt atcattttataacc[a/g]aatcatgttcaatcagtaggaaatagtggcaaaagttattttagtgtctatcttagcatt/ a/BICC1/bicaudal C homolog 1 (Drosophila)/ 4412/11/rs2285676/17364601/[c/t]/gtggctccaagaagtgcctgtggtcaggccccagctctacttggtcc 40 ctgaaaaagcacc[c/t]ggctaagggctgggcctggccagcagggagggcagttgatgagagagggtgttcccgctg/c /KCNJ11/"potassium inwardly-rectifying channel, subfamily J, member 11"/ 4413/17/rs2945395/22909096/[t/c]/actggctcctatgtaatgtttgtgtgcagcagttggagctctgccgc acggatcatgggg[c/t]gatgtttttactcctgtattctgtgcccccgagtcaggcttttcttccatggattttggg/t /KSR1/kinase suppressor of ras 1/ 4414/6/rs4527692/21268426/[t/c]/aagtcacctatctccaggtttgaaagtttccgtggaagaatcaataag tcgcttttggct[c/t]taaaatggctcctgagcagtcacctttttgttttcatcccatctgttgttttcgaatggg/t/ CDKAL1/CDK5 regulatory subunit associated protein 1-like 1/ 4415/8/rs3808480/97386585/[t/c]/acagtgtgctccatcgcataccaccaggtggttccatcctaacggcac tatactactctc[c/t]ttgacacatccaatcattcctccttgtaataaaagaaagcttctgctttccgtgacattg/c/ 50 (310) JP 2010-88432 A 2010.4.22 PTDSS1/phosphatidylserine synthase 1/ 4416/3/rs9637365/127852856/[t/c]/gtacgggaagatctgccttccaagcagaagcaaggttcttaattctg cccactggagcaa[t/c]gctcacctccaagaatgaataaatatttcagagaggcagattttgcttcacttaaaaaaa/c /TXNRD3/thioredoxin reductase 3/ 4417/21/rs2830266/26800371/[g/a]/caaaggttcagatgataggaaggttcagatttccctctccatctaga aaaggggcccttg[g/a]gaaatttgaagtcctctttcttttccctagctagactttaattctcacccattaatttta/g /CYYR1/cysteine/tyrosine-rich 1 4418/5/rs3763009/150392333/[t/c]/ttaagagattggctctggatttacaaagacctggattcaaatccaag cttagccattctc[c/t]ttgctagatgaccttcagcaagttatcccctctgagcctcagattccttacctgtgaaat/c /TNIP1/TNFAIP3 interacting protein 1/ 10 4419/1/rs7527268/7096482/[c/t]/gaaaggagtgagtgcttcttgcatccaagtgcctggcagaaatgaagtc actttggtgag[c/t]gaggttttacttctccgtcctttggtccaaggctactgggagggtcagatggtgaaatac/t/C AMTA1/calmodulin binding transcription activator 1/ 4420/8/rs4360298/70865695/[a/c]/taaacacaactgctgcccaggaagactgagtaacaactgagtgagtag aaccagaaagaa[c/a]aaaggccagaggcataccatgacttcaggggatttgaagagaacagagagctgttgccag/c/ SLCO5A1/"solute carrier organic anion transporter family, member 5A1"/ 4421/5/rs2305049/133971836/[t/g]/tcaccaagaaaatgtttcattccatggtagaaagaaatgaggacatt aaaaagacccaca[g/t]gtataaatgacagttttctttaagaaaatgataatgggcttgtatagttggacaatagta/g /SAR1B/SAR1 gene homolog B (S. cerevisiae)/ 4422/19/rs8099879/17091287/[a/c]/caggaatgagcgagtgctgagatggagtcacaggacactgaggcagc 20 agggaggccgagg[a/c]ggggagcctgggcggtcctcctatgcctgagtgcgctcccatccttactctggaactgcc/a /MYO9B/myosin IXB/ 4423/2/rs1463616/141027191/[g/a]/aaactccccaactgattgcctcattgacaagattataaacaatcatt atgagaaatgaca[a/g]cttggtccctgccatggctgggtatgatagaatgttactgatttcaaagaaatgtggtaa/a /LRP1B/low density lipoprotein-related protein 1B (deleted in tumors)/ 4424/5/rs2973696/177680750/[c/t]/tgtgcttgatgccgctcaaccgtccactcaagaatggttaagatggg acctttcatgcta[c/t]gtattctaccacagtttttacagaatagtttagaaatttacaaatacagtgtaatcttcc/c /COL23A1/"collagen, type XXIII, alpha 1" 4425/7/rs10250971/157173700/[t/c]/aaatgggctatttgttgagtttttccaggcatacacttaaaagtga atatacaagaaagg[c/t]aataaattgtctatttgccatctttaagcactcctaaaacatcagttttaaagaaatact/ 30 t/PTPRN2/"protein tyrosine phosphatase, receptor type, N polypeptide 2" 4426/8/rs6558551/1769902/[a/g]/agcccttgcgagactgaatgcatttgcttctcttttcactgttttttct tttctgggagc[a/g]tgcagaggaggggagaagatcccacggagacggtctcagtccgaggtgagcagagcgtaa/a/A RHGEF10/Rho guanine nucleotide exchange factor (GEF) 10 4427/19/rs745952/55189335/[a/g]/gcagagcagggagcagcataaacatggtttctgtgtcttagagctcac agtctagtggga[a/g]gggccaatagtgaatcaaacagttgcacaaactatgacaagtgctctgaatagaagcggc/g/ VRK3/vaccinia related kinase 3 4428/18/rs8084058/70328445/[a/g]/gcacatccatgaacagggctgtctgggggcagcctgggtggtcgtga aataggactcagt[a/g]gccttgagtcctcatttaggccctgatgttctttagcctgcctggcctttggcaaatcgc/a /CNDP2/CNDP dipeptidase 2 (metallopeptidase M20 family) 40 4429/19/rs8101040/55255711/[a/c]/tgtctccgagtctgaaagaaatggaaaataccaataccacctgtccc aggacaaagcaag[c/a]tgattacttggaagtggcagtgtaaacctaaaaaaaaaaaaaaaatttcaaactcgatgt/c /FLJ26850/FLJ26850 protein 4430/4/rs3796938/109730683/[t/c]/ttgtcatgttgaagcagggtgaccgttcaaactgttgggcagaaaaa tttctctgccctg[c/t]gtttctgctgtgaggagttcttgtcttcctgaggaagcattacagctaatcatgatgtgg/c /FLJ37673/hypothetical protein FLJ37673 4431/14/rs8009997/54491661/[g/t]/aatatgtatttgcacataaatagaataattttggaaagttccacaag aaacttgttgcag[t/g]gattgtttttggagacagaaattagttggatgaaactacttattatcactcttctttttg/t /WDHD1/WD repeat and HMG-box DNA binding protein 1 4432/3/rs1534725/62420416/[c/t]/atagttacactgcactggctactctctctttctgagtaatcaccatgc 50 (311) JP 2010-88432 A 2010.4.22 ttgtaaactacc[c/t]gttgagaatatgtatctccctcatgcaaatgtccaataaacagcattgtccatcttatcc/c/ CADPS/Ca2+-dependent secretion activator 4433/4/rs1517945/138157786/[t/c]/aaaaaaaaataggtttcatattttcccatctctattttaagcacctc cttcctctgggtt[c/t]ctatattatggcctatctgctatcatgtaaatccaaagcttgaataaattttatgcatta/t /LOC729578/hypothetical protein LOC729578 4434/6/rs12190255/151028118/[c/t]/tgcctctattgtcacccactcttccccaaaacactacgtcattaga agagaaagctaata[t/c]aatagaaaaaatagaacttttcttcctgcctgtatcaaggcagtaatgatttgatttaat/ c/PLEKHG1/"pleckstrin homology domain containing, family G (with RhoGef domain) member 1" 4435/17/rs7207916/42234514/[a/g]/tgagaccactcaacgaagcctcatctaccatgtgcccagtattgaaa 10 agtttcatgccag[a/g]ttcacaaactgttaaacataagatattctatccagctcattaagctgtacactgacaagt/a /WNT3/"wingless-type MMTV integration site family, member 3" 4436/17/rs2289534/75654214/[a/g]/cattgtttggtaagatttcagcgattcttaaatcctttccaacactg cggcgctgggagg[a/g]gagaggcttttctgctcagatttcctggcaggattaagtagaaacagagcagggtaaaga/a /CCDC40/coiled-coil domain containing 40 4437/17/rs2289672/40287770/[a/g]/tccagattacgtggaacaggtgagaacagggctctgacgccagggtc gaaaggaggcagg[a/g]atgccacagtttaactgccgggtctctaagagcacacatctttctggggagcatttatgt/g /EFTUD2/elongation factor Tu GTP binding domain containing 2 4438/3/rs11929640/114771120/[g/a]/aggactcaaatatttatcttggtcctctctaccctccttgacatag tgttatacccatac[g/a]gaaacgtggacagataaatgaatgagtggtcagaaggatggagaaggagtcacagcattt/ 20 a/SIDT1/"SID1 transmembrane family, member 1" 4439/12/rs10785430/42105565/[g/a]/aagaaaaacaatgaactctccctcactcagactcaaactttaaagt atgacatgttaaca[g/a]acaagagtgctatcataccgatgtccatggttcctgatgccatgacacatcagcagggca/ a/ADAMTS20/"ADAM metallopeptidase with thrombospondin type 1 motif, 20" 4440/21/rs222972/26800448/[t/c]/tttcttttccctagctagactttaattctcacccattaattttacttt aattctaggtca[c/t]cacgcctctagcctacagtcatgctcccatcgaaatgcccctgcttaatttatctgcatt/t/ CYYR1/cysteine/tyrosine-rich 1 4441/1/rs10917454/19668438/[t/c]/ctatatgtttatttcagtgtgtactttctatatacagcaattgatat tgttttccattca[c/t]ggtaaggacaaagtttccttcctaaataatttaagttaaaaagtgaggaaacttaaagaa/t /CAPZB/"capping protein (actin filament) muscle Z-line, beta"/ 30 4442/21/rs2284976/43061181/[a/g]/ttcaggggatatcacctgggctggggtggccagaaaggctggaagga ggggacccaaaca[g/a]gaccttgaaggttcattctccattgagaagggagcctgtcctccctgaaggcagccaagc/g /PDE9A/phosphodiesterase 9A/ 4443/9/rs4740745/397575/[t/c]/acagtgcttctcaggccaagagacaccacacatccagggcttctgaatcc ttttacctct[t/c]atctatctgattactcagggacatgtggcagtatctagcctagaagtcaacagacagaga/c/DO CK8/dedicator of cytokinesis 8/ 4444/8/rs1877673/22638219/[t/c]/cccaagaaacaccagccttcgaccccagtctccaaggctcatgagtgg gggtcaaggccc[c/t]aatttccccgtaaatgcctgaagcgtttgttccaccccagaattcaccccggtggtggct/c/ PEBP4/phosphatidylethanolamine-binding protein 4/ 4445/5/rs4701085/178606682/[g/a]/actcacaggaaataaaaaagaccttccctgaggaagcctagacacct 40 catgtgccagaca[a/g]agattttaaataaattgtcttaaatgtgttcaaagaactaaaagaaaccatgggcaaata/a /ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2"/ 4446/5/rs467604/178600590/[a/g]/actcaagctcactcctgccattaaactctcctgagatttgagtttcct cctctttcacaa[a/g]accggaaatcccttgtaagttaagccaagctcattaacgttgtcttctgcggcatccata/g/ ADAMTS2/"ADAM metallopeptidase with thrombospondin type 1 motif, 2"/ 4447/4/rs6812694/20924160/[t/c]/accaaagaaatataaaatgtaaaaagcaatatacaacaatctccttga caattattcatg[c/t]ttatatgctgtagtttaattactaacaattctaactactcacttgttattaactttgatt/c/ KCNIP4/Kv channel interacting protein 4/ 4448/1/rs1567449/216085579/[a/g]/gaatttcttatagggcacatttttttaagagaaattttaatctcttc aagaaagttcagg[a/g]taacgaatgaaaaacataaaattgctgagctgcagaaaccaagcagtagtctgggtttta/g 50 (312) JP 2010-88432 A 2010.4.22 /SPATA17/spermatogenesis associated 17/ 4449/9/rs2027393/4059813/[t/c]/cacctcaagctggagaaggcatagtgtccttggagttagtttttcttct aaaatgcacaa[c/t]ggtattttagaatgattcccaaatctttcataaaagagctttggcaaaataacaaaacag/t/G LIS3/GLIS family zinc finger 3/ 4450/1/rs7544659/173913664/[a/g]/ggcaaagggctaccgaaatgaaaggtgtttttattaagtagagaaga aggaagatcaaga[a/g]tgacagagagaggaaagagaagccagggggctaggagtaagtgccagcaggaatgagtgc/a /TNR/"tenascin R (restrictin, janusin)"/ 4451/11/rs1470899/83663719/[a/g]/cacaactttcagaaaatattccttcactagtaaatgttctgaatttc tcaggaaacaaca[a/g]gaaaataaaaagctgtcttttaagttaccttccaaaatcccagtcattcctctctgaaat/g /DLG2/"discs, large homolog 2, chapsyn-110 (Drosophila)"/ 10 4452/6/rs380779/2809294/[g/a]/atgttgactttggcccaggccctggggatataaagatgaaaaggtaattc tgccctgtaa[g/a]ctctttgggcaactgggagtgatcctgtattcagtgtgtcaagtccacctccccttgggg/a/MG C39372/hypothetical protein MGC39372/ 4453/13/rs387298/109957629/[g/a]/ctgcccccgggaagcatgttgctggctcatggtgccttcacattcct gcctgtgcgcccc[a/g]cctccacaatgagtttctaaagaacaacggggcaaaggccgccaaggataagggccaaaa/g /COL4A2/"collagen, type IV, alpha 2"/ 4454/5/rs1982301/179482982/[c/t]/cgtattctcaagtagttaagttcaagtttccgtgtttgtttattgct tcaaattgtgttg[t/c]tgagattcatattcatcctgggttgcgttttgtttttctttttcaatctccctaagctac/c /RASGEF1C/"RasGEF domain family, member 1C"/ 4455/10/rs10905806/6192316/[a/g]/gtaatgatggggcttgttcaaaacagcaacctcccagtagaagtttt 20 gactcattttgat[a/g]ttgaacattattttcctagacaggcacagaacctgattaatgtttacatttgccttcata/a /RBM17/RNA binding motif protein 17/ 4456/18/rs496344/22454126/[t/c]/tttagccacaataaggaattcagtcatcagtccccgcattccacagaa tcttagtgtcta[t/c]attgtgccagacattgtgttaaggtctgattatgagacagaaaaaataccataaaacaaa/t/ KCTD1/potassium channel tetramerisation domain containing 1/ 4457/3/rs6767291/58383950/[c/t]/tctcccctcctcctggtatttcactggttgctctccagaagtcctctt cagaggaatgct[c/t]atcacacatgcttattctccgttttcccacttcaacagttacttcaggtttaaagtcctt/c/ PXK/PX domain containing serine/threonine kinase 4458/20/rs1238232/8332822/[c/t]/aaaacataggtcagttaactcttagaacagagcatttattccatgaaa tcacaaaaccca[c/t]tgctttcaatgaaagttgattgtcaatattccttcaataaaatttgtctgcaaagaaaaa/c/ 30 PLCB1/"phospholipase C, beta 1 (phosphoinositide-specific)"/ 4459/11/rs713503/16956458/[t/g]/ttactcatgtaactgttttgcatcaggtctctgtgaacaaggaccatg ccttgcttttgt[g/t]tcccgtgtttccttcaagcaataggagtaggtggccactaattactgcagaatttaattg/t/ PLEKHA7/"pleckstrin homology domain containing, family A member 7"/ 4460/8/rs10107716/3947005/[c/t]/tactgtcacagatatgcagaaatcccaagtcagtcttctgagatcagc aagttttacctg[c/t]gctgcactaatttctgaagtaatgctcattgaaacaaataagaaatatataaaaacaaaa/c/ CSMD1/CUB and Sushi multiple domains 1/ 4461/12/rs2374448/104170239/[g/a]/tgttaaatcatgcactttaaaatgttcaattttatgttatatctca gtgcaaaaataata[g/a]agtttttaaaatgggttctaggctgggcactgcggcttatgcctgtaattccaacacttt/ g/OCC-1/overexpressed in colon carcinoma-1/ 40 4462/21/rs7279886/43042997/[c/a]/ggagcaacttgggatgagttcatgatatgttagatgacaaagcaggt tgcagcagactga[c/a]tttggtgcaattccatctttgtttaaaagtacaaaggggctgggcgcagtggctcacgcc/c /PDE9A/phosphodiesterase 9A/ 4463/21/rs2833573/32245680/[t/c]/gtgaatccctactggtaaggaaaacagaaattgagagttctataccg agaagattgagaa[c/t]gcaacgttgttggactaaagctgtcctttgctctcatgggggtccctgggatggatgggt/c /HUNK/hormonally upregulated Neu-associated kinase/ 4464/14/rs7143719/80657402/[a/c]/attaaaggcgtctagacagagaaatcatgtggcctgtgcaggtggga gaatcggaatgcc[c/a]tcagccttctcaatggcgacattgaagaagaccatagatagaatacacctgttgaattct/a /TSHR/thyroid stimulating hormone receptor/ 4465/7/rs3778677/80249040/[t/c]/acaatagactgcatcatttaatgtcttcaggctagaaaattttcctta 50 (313) JP 2010-88432 A 2010.4.22 cattcctatcac[c/t]agagggttaaataggggcaacactcagggatgtggtctgactgtaattgttttcaagtca/t/ SEMA3C/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3C"/ 4466/7/rs663302/103185721/[a/c]/ttttcagaagtgaatattttttctgtaaggtaggatgttcaactagga atgaatgttcgg[a/c]taggatgaatctaggaatatccaattctgttaagagttccctgttagaaagtgcatgtga/a/ RELN/reelin/ 4467/8/rs2350620/62660161/[t/c]/caccctgcgtatctctgttttgtggtccttccccactaggggttttgt tataatccttca[c/t]gcgcttatcttagtcctaactcttgcagggtggtaccgtgtcttaaaagcaggctgaatc/c/ ASPH/aspartate beta-hydroxylase/ 4468/7/rs16622/141932985/[g/a]/atacaagtctttttcttgggattacaacatcagggtctgttgttttcta 10 ttacaggacac[a/g]tggatgctggaatcacccagagcccaagacacaaggtcacagagacaggaacaccagtga/g/T RBV10-3/T cell receptor beta variable 10-3/ 4469/9/rs2383024/17477945/[g/t]/tttgacatcactgacagcatgtaatgtattctaaaactttttcattat agttcttttggc[g/t]taacctaattttttattttttaaatggactggaataaataaaagccaaaacatatttgtc/g/ C9orf39/chromosome 9 open reading frame 39/ 4470/16/rs10500334/6195417/[c/t]/tcaaagctgataagtcacctgagatgaaattgaacaaggttgtcgtg acaaagtaattaa[t/c]ggcattttttgactttcagatgactttaggggaagcacacttcttctctgcgtctgcttc/c /A2BP1/ataxin 2-binding protein 1/ 4471/7/rs1693381/83011868/[c/t]/ggaaacgatgtaaatcatgaccttcagtttttcccataaataaaatga aaatattattca[c/t]atctacaacattgagttgtcacaatagttaaataagataatgcatataaattacttagga/c/ 20 SEMA3E/"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, ( semaphorin) 3E"/ 【０１９３】 〔実施例５〕抗体製剤群のDAS28ESR有効性判定に関連するSNPの探索 Human Hap 300 Bead ChipならびにHuman CNV 370-Duo Bead Chipに搭載されているSNP が抗体製剤群のDAS28ESR有効判定の個人差に関連するか否か、フィッシャーの正確確率検 定で解析した。 有意水準0.1%において262SNP(71遺伝子)が抗体製剤群のDAS28ESR有効判定に関連してい た。また、有意水準0.1%∼1%の範囲でも1022SNP（580遺伝子）が有意に相関していた（表 １７）。 30 【０１９４】 〔表１７〕 整理番号/染色体番号/NCBI_SNPリファレンス/染色体位置/SNPの種類/配列/TNF阻害薬治療 有効SNP(DAS28ESR)/遺伝子シンボル/遺伝子名 4472/3/rs982953/24486257/[t/c]/ataaaaataagttacccaaacggttttccattctttactcgtacctcac tctttaccacg[c/t]gctcatagtttgttgctcttcaacacttttctctaaataagttaataaaatgtattcttc/t/T HRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) onc ogene homolog 2, avian)" 4473/3/rs3903470/24483025/[g/a]/tgcagtatctccaaagtgtgcctgtagttgagattggagggtactcta aacaagaattag[g/a]taaatgtgtgcatactgaacacggagccagcagaactcttccccactgggtttccggaac/g/ 40 THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on cogene homolog 2, avian)" 4474/15/rs1562253/99911601/[g/a]/aaccttattcccagagacagtaactaagtcatgccatggggcaaagt gggctttgcagac[a/g]cagttgaagttcaggagcttgagatggggtggtgatcctggattttttcaggcaaaaaca/a /-/4475/5/rs1363602/169539456/[t/c]/aacagatccatgaagagggaggctgagagactcactctgtgtcctcg agtttgccctgac[c/t]gactttatggagattccaggagtgactctggtcttgtctgggtcatcacagggcattttg/t /-/4476/6/rs4896886/147095325/[t/c]/tggatgaaagagagcccaggtggttggttcaccatttcatgctacca agattactcctca[c/t]gggctcaatgtagctggccctgatttaatatgtaaggggtcttggtgaatgaatcactta/c 50 (314) JP 2010-88432 A 2010.4.22 /C6orf103/chromosome 6 open reading frame 103 4477/8/rs6468553/98446725/[c/a]/ctattttcaaacactggagtccattaagttttgcaacttccaggggaa gttttgaatagt[a/c]aactgcattaattttgatcaatttcagctcttagcccagcagcagctacccgtccctcac/c/ -/4478/8/rs6982054/56771942/[c/t]/gagggtagccaccctcacatgactcgacatgctgaagggggcaacctt tttgtcttaatc[t/c]tgatactgggagacagaaagaaaattatcttaggatatgtaaacacaaattggccttaac/t/ -/4479/5/rs10037701/147521356/[t/c]/agtatatagctagatggaaagaaaataaaaaaaagtaggggaggta ggtgttgccattct[c/t]attctagcactgcggaaggtcaacagcattctctctcagggtgctgcaaccttttataca/ c/-/- 10 4480/2/rs6755974/107072418/[a/g]/aactcctaagtatccaaaaacattgtgattgaaagctgccttgagtt aaaaatgttaaca[a/g]aagaagaagtgttgcaggtttaatatccatgcaactgcttccatgaaagagacataggag/g /-/4481/18/rs999861/4629465/[a/g]/tgcctggaaaatgatcaatgtggagtctgcagaatagcagactgatgca atataaaaaag[a/g]gataatttcacagcctgttttttaaagtatagtgatactggttgtggggatggcagcatt/a//4482/3/rs3732410/122898410/[g/a]/aaaaggcacaggagaaagaaagacatctcagggaggagctaaagcaa cagaaagatgact[a/g]taatcgcttgcaagaacagtttgatgagcaaagcaaggaaaatgagaatattggagacca/g /GOLGB1/golgin B1 4483/3/rs7153/122865987/[t/c]/gctcattctgtgttttacgggccatctatagacttagttgttactctttg 20 gaccactccc[t/c]tcaaaacttggaattctctcacctctaacatcagaacatcaattccagtggaacagtctt/t/GO LGB1/golgin B1 4484/6/rs162990/155754137/[a/g]/cagatcagtagggtaactatagtttacaataatgtattgtacactttg aaatagaggagt[g/a]gaatctgaatggttctatcaaaaggaaaagacaagtatttaagatgatggatatcccaaa/g/ -/4485/6/rs335419/155716021/[t/g]/tgctagtacttctctgccccagcctgggagatattctttccacacagg gaactgttggga[t/g]atttacctgtccaagcctttgtgacaggtttttaagtctctgtcccaccgaaaatcatga/g/ -/4486/3/rs1609729/28278115/[c/t]/taaaacaataaacaataaactatgggtcagaggggcctgatctgggaa gactcaaagttc[t/c]ggtggctctggtgtgcattttaaacacaacttccaaaattggactaaaatggcaaattga/c/ 30 C3orf68/chromosome 3 open reading frame 68 4487/8/rs6994118/98438230/[a/c]/actctaggcatagtcatgtaaaagtcaatcaatcaatacatggattaa agtgtattttga[a/c]tatataacactaagcagtatcacatcctgtgggagcctccaaggtaaaccagtaacaaaa/a/ -/4488/21/rs13049429/41026989/[c/t]/ctggaggggcaaaaggccaggtagttgctgcactcgtaaataaccc actggagaggcact[t/c]acagggaggcaggctggagacaagtgccaggggaggtatgaaccaggagcttggaaagaa/ t/DSCAM/Down syndrome cell adhesion molecule 4489/13/rs9517243/97726512/[t/g]/ttgatgaaatgaggaagcaagatgctaagaacaagacccatttctca attattgagtgtt[g/t]tagagtctctgaaaaagatatttagaagcaccagagcctgctaattttgcctggggttta/t /FARP1/"FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-deriv 40 ed)" 4490/5/rs12655663/147645416/[c/t]/aatcaatggacagtgtgaaaacagtgaaaaatttgagcacagagca aattgcgtgaatta[c/t]gcatagcattattgctgtggttatcttttacctcttggtaaaaaaaaatctggtatttct/ t/SPINK5L3/serine PI Kazal type 5-like 3 4491/5/rs1423246/59697213/[g/a]/ggatgaatcaatagatagataaatatatcacacctaaattatcaagtt tccctgaacagc[a/g]aaggcttagagcaggcactcttgtaccaagggcgctgagattacaacatttcttgaactt/g/ LOC653198/similar to phosphodiesterase 4D 4492/5/rs4580739/59691437/[a/g]/gtaaattggtgtctgatccacctgttctctttcttatccatctacccc cacaaaacacac[a/g]ccttctcccatgtttctagtgccatattttcttacccaacatgacatgctccttcctcac/a/ LOC653198/similar to phosphodiesterase 4D 50 (315) JP 2010-88432 A 2010.4.22 4493/2/rs2030677/107046172/[a/g]/ttcactaggaggcacaccagtaaaacatgtctggcagaaacagaaga aaaagccagaggt[a/g]gacacagctaattgtatttatgtcaggttttgagaataatcaatatgcctttgctttatt/g /-/4494/2/rs2030675/107045906/[t/c]/aagagttctttatttgactgccatcctttgctgtttacaagtgcgga tactttgatggtc[c/t]aggaagagagagtgtgcattgtgtgctcttaatgagcacttgtgcactcagccatgcgca/c /-/4495/7/rs6980283/146381187/[t/g]/attattgtagggataaggctaatgatgaaagtgcacatgatagatac tttcacataattt[g/t]ggtataagccttttttgcaggggttggctaaggtagatagctagtggatcagatactcag/g /CNTNAP2/contactin associated protein-like 2 4496/4/rs3923442/88408757/[g/a]/gatcagaactttcggcctatttaatgattgactgtagactcaccgcct 10 aaatcgctttag[g/a]cccttcctgatttctttttgttccagggtcatggactagtacttattttcatgggtgact/g/ -/4497/1/rs12030672/50507982/[c/a]/atgtaaaaatgcagaaaaataggacccacattgagaagacgcatatt cattaggaactga[c/a]acagatattagaattaggaaatatagacaataaatagttatgactgtattctctctgttg/a /-/4498/11/rs1933343/30267568/[a/g]/gatagaaaatgtaggtggaaaattctatgccaggcagagggaataag attttacatggca[g/a]ggaggggtgaaaacaccaaatgtactgaattgatggtgaagtgcagcatcagaagtaggc/a /-/4499/11/rs1222208/30317953/[c/a]/aacaatttctgttgtgtgtagatcctagtagagaagttaggtcacaa atgttggtctcac[a/c]caatgttggtcacaaatattaaggtagaaatgcatgtatatatttgaataaaatgtcatc/c 20 /-/4500/6/rs517924/109131382/[c/t]/tttatattgaactttaataagtcaaggatgcatattgtcatctttaag tctagaagcata[c/t]atttaattccacagaaagagaagtcttgtgctcatgttagaaggtagtcttgatttgtct/t/ -/4501/2/rs10498150/224085278/[t/c]/ctttaacactactgtcctctgggaaatcctccttgacactccagcc taggttaacctcct[c/t]gggatatgccagttacactgcacttctttaaaacactcatcctagccatcaggtttcata/ c/-/4502/3/rs7611318/28259900/[g/a]/cgcacccagcctaattatggtacttctgaacttgaagtgacctttaaa gtaatctcatac[g/a]gatgaggagactgagaatgagagaggttaaagatttccatatatctacactttttgaatt/g/ C3orf68/chromosome 3 open reading frame 68 30 4503/8/rs4244456/19754748/[t/c]/aggtaacttctgtgtgcctcaagctctttgtctgaaaacggagctgag tggtcctcccct[c/t]gctggttattgggaggatgaaatgttgctccacgtgaaatgcttgggagagggccttgag/c/ -/-// 4504/3/rs9819530/122870474/[g/t]/ttttgttctcagatccaaagtttcctacaattttcttataacttaaa gcaaaatcaacac[t/g]ttctctgtttcagagtaccaaatgtctcagtcatcactgtttcctactcatgttttgatt/t /GOLGB1/golgin B1// 4505/21/rs3804025/40986377/[t/c]/agcagacgtaaaaccacaattttctcaaaaaagttaacacaatggct acagttacagtgc[c/t]ggtaactaatctctcttcatcagtcaacccaccaaaggatgtctgaatcaagccattata/c /DSCAM/Down syndrome cell adhesion molecule// 4506/8/rs9649913/98455684/[g/a]/cccaaccttaaaggacattacagtggggaaagatggaatgaagcaaac 40 aacaaattctac[a/g]cagagcagaagaaaaacaaatgctcaaatagagggaaaatcaaagctctgggggaacaaa/g/ -/-// 4507/4/rs11930234/153854819/[c/t]/ttccctatgtccccctgaggcttcatttcctatctcagacgtggcc tgcttgagtcaaga[t/c]gacttctttgctgctgttgatgggagttgtgggtttacaatctgtgtgcacttggaccac/ t/-/-// 4508/7/rs6970317/139660894/[g/t]/catgtaaattcagtaaaactcattccgactttaattaaacagcccag agcacaggtccta[t/g]tagtggtgggctggtttcatctcttatgtgaaagaggtttactgaaaaaagagcagcgtg/t /-/-// 4509/6/rs259405/147145109/[c/t]/tgacttaatgattttaggttcagtggattcctatttgcctatctcgtc tgaggacaaaac[c/t]gtgaaacattctttctccctgattccagaaaccatctagatactttgaggacattccttg/t/ 50 (316) JP 2010-88432 A 2010.4.22 C6orf103/chromosome 6 open reading frame 103// 4510/3/rs6800659/28245673/[g/a]/ttgtcacagatgaagttatgtcccctgccttaaagctcacatgttgaa gctgtaaccctc[g/a]atgtgactgtgtttggagacagggcctgaaaagaggcaactaaggttagataatgtcata/g/ -/-// 4511/5/rs37775/52663553/[c/a]/tgcttctttgtttacaaaaccccaaacaggtaactttttcactggattct agtttcatca[a/c]gtaatttccttttgtttacacaaatatgggatgcaaacaaatgaaaaagacaaacttttg/a/-/ -// 4512/1/rs1020368/102014029/[a/g]/aaaagcttttaaaaaatagcaagtagcaccaaatgtctaaggcatat gatacatgcagga[a/g]aatattgaaagtactaaaaagtatgtgggagagtattgatctagatgctaaggattctgg/g /LOC730029/similar to 40S ribosomal protein SA (p40) (34/67 kDa laminin receptor 10 ) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-as sociated protein MGr1-Ag) 4513/3/rs11129315/28283335/[g/a]/aattaattgatttaaatataaaatttaattttatagtattctttctt tgctagtgatatt[g/a]ttggtggtgaataaagccgctaaaataaatgactgaagtatactggtagatattaacaca/g /C3orf68/chromosome 3 open reading frame 68// 4514/5/rs37691/59758842/[a/g]/gaagtttagcaaaccccaagaagaataaatataaagaaaaccacacccag gcacattgta[g/a]taaaactgcagcacatccaagataaagaggaaatattaagggcatccagaggaaagacac/a/-/ -// 4515/5/rs789389/59742783/[c/t]/gttctaattttttcaagtcacactcattctaggttgtaataaagcatgc actggtataat[c/t]ttcattgctgataaaaaggataacttccagaagggttcattttccattaactgtaaaaat/c/- 20 /-// 4516/5/rs3776578/36687743/[c/t]/ataaagtgttgtgaaagtctccactttcatgttaaaaagtactatatg ctgcataacatt[t/c]ttcagaaagggttattatggaagggccgagggtcaaagttccaaggtcctgaaagtatta/t/ SLC1A3/"solute carrier family 1 (glial high affinity glutamate transporter), mem ber 3"// 4517/6/rs162989/155751623/[c/t]/gaatgactggttgatgaagcatggtgagcagggctttattcttgacag tagcatgcagga[c/t]ctttgcctgtaagtttgtatagtttgcataaagtgggattaggcttaagcaatagtatta/c/ -/-// 4518/22/rs854961/18658004/[g/a]/ttctgacccctgacattcggacctccagcagagcctgcagtttgagac ctctggttcagg[a/g]gctgggactgatggggcccttggggattcccgtgctgctggaggaagatgggggcatggg/g/ 30 -/-// 4519/10/rs2960374/86605061/[t/c]/atgaacatatccagcaaacctgaaggtaaccttctgcctgtttatca tttcatcctctgc[t/c]tttccaactccctattcccaggcaagtactgatctgctttctgttactgtaaattactct/c /-/4520/13/rs9319110/84510389/[t/c]/acacttgtgaagacagatatgtgttgtaataattagaaaagccatat ttacattgattaa[c/t]tggactatatttgacaaatagataaaaccacttatttaatatcagataaatctaatctat/c /-/4521/5/rs918592/59733060/[a/g]/ccgtgggcttgccgtgagagggaggctccatcctcttttttaacataag ggcaggagggt[a/g]tgcacactccagagatgtgtgtcatttactctttgcagcttcagcaattgagtagactga/a//- 40 4522/5/rs171710/52478988/[a/c]/ttgaagctgtagttctgcaactcacttactgcgtgactttggacatctt atatcacccct[a/c]caggtttcacttttagcatctgaaaaatgaagagattaaagtaaatgatatataaggacc/c//4523/22/rs2050140/35301903/[c/a]/atgctcttatcccatctgggatttgactcatcattaggatgaattag gatcattaggatc[a/c]atccgcattaggggatacagtctacagtcacagacctgcacagacctgctgggttgcaag/c /CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 4524/13/rs2806967/52532090/[c/t]/ggatatttgttttgtcacttgtttctctcttccttgcttttggtctg gttttggggaagc[c/t]gcaaggagacacatgcttctaccttcacatagcaattcagtgacaaatagaaacatgaat/c /-/4525/22/rs5752867/27843729/[g/a]/ttgttatatcttcagttatataaaccatgaggaacaaatggagaaag 50 (317) JP 2010-88432 A 2010.4.22 ggaaaggacttca[g/a]ctgatagtggagtgattcataaatcgataacatagatggaaaactaaggtccacagagat/a /KREMEN1/kringle containing transmembrane protein 1 4526/15/rs934192/52182570/[a/g]/ggtagattttgtcctctgtgactgaagttcattgtctggcagtttctg agggtacaaatc[a/g]gggagagaaagccctctttctgcagtatttttctcagaagtatttgtttcattccgatca/g/ UNC13C/unc-13 homolog C (C. elegans) 4527/1/rs12406116/107245624/[c/t]/atcagaaaggaataagtccaggaagacaaattgtgcttcttatgac tataagagatgtag[c/t]gctcagtagagtgacattacttttccagcaaaataaatcagagaacctcccccaaatatt/ t/-/4528/8/rs7465067/144916943/[a/g]/taaggagaacacacttggaacagcagctgcaaggggagtcaccttct gattaagctgaca[a/g]tgacctaggcattccccaaaaccatcattttctattgaaataaaactggagaatgaagtc/g 10 /-/4529/8/rs7462131/144918819/[g/a]/ctaaaaaaaccaaacaaaacaaaactgaaaaaagaaataacaaacgt gcaaacatttgat[a/g]aataatccaaatatttctctctccatttttacaggggtaaatttccataattatgaagag/a /-/4530/8/rs4074060/144923639/[g/a]/ggggacatacactaagtaaattattcctgtttatctgaaattcaaat ttaggccaagcgc[g/a]gtggccttgtaatcccagcacattgggaggctgagatgggaggattgcttgagcccagga/a /-/4531/8/rs4875051/144932865/[a/g]/ccatcaccatcccttcatcattcatcagtcatcgtttccatacattc acccacttcatcc[a/g]tctcgccccagtattggtttgcgctttcgccaattcataattatcttattaacttgagtc/g /LOC642574/similar to CG3104-PA 20 4532/17/rs4790823/1151041/[c/t]/gagtggactgctcacccccggattgtttggaacccccttgaccccagc agcacaaacaca[t/c]aggccagaggcgagcacgtacattcaggtttatttatttccatgctaagacacacagcgg/t/ TUSC5/tumor suppressor candidate 5 4533/10/rs1925562/68392092/[g/t]/aaaacttagaggagttgaggaggcagacatttggggcaagagtatta taggcagaaggag[t/g]tgtaagtacggagaccatgaggaagttctcttcctgtaataagccaaagagaggctagtg/t /LRRTM3/leucine rich repeat transmembrane neuronal 3 4534/8/rs10481092/98511712/[t/c]/agattgctttgcatgaacttacttaccgccacgtgaattccatcctt atagagcctttgg[c/t]gcttccctgccatgccaggtttctcttgaagaaaagtggtatctgaataagtatttacag/t /-/4535/8/rs2331465/98497948/[g/a]/aaatcgtgggaatttcagtagacctgacatgcagaggagatccagttt 30 aggggaataagc[a/g]tagcctttgaaatagcatagatctgagtttaaatagcagaagtaactagaaaatagttag/g/ -/4536/3/rs4353759/24487960/[c/a]/gcttatcagtgcatactaaattaataattgatagtcttttagaatttg ggcctccaacat[c/a]tatctaatgcaatgttgtggttttaaatcctttttcaggccttcttgatttggacccacc/c/ THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on cogene homolog 2, avian)" 4537/5/rs252046/52686504/[a/g]/gtttgatttccaaaagctactctgttaatacctcttaaatttagaggca taattgaagaa[a/g]aatgaaacttggagttcccaaatctttaacgaccctcccaggagccaggttagaaactct/g//4538/5/rs26956/59826742/[t/g]/atggactgaagttagatatagagcaactcatgtctcttttagttgctggt 40 gattgcaaat[g/t]tatctccatggccaaattgcttttgaggcactatatgtgatatttatctgtattgtggga/t/PA RT1/prostate androgen-regulated transcript 1 4539/11/rs1981405/77653856/[a/g]/tatatatatatatatatatgtggtatagaaggcccgtttattacata gggtcttagaatc[a/g]catgaatatgaacccacaacattaatgactttagtctaaacgtggtcttggataagtaaa/a /GAB2/GRB2-associated binding protein 2 4540/2/rs1427588/137208796/[a/g]/ttgatcagtttcataatatgaactaggaattgctgatcacagctgac atcttttatctcg[a/g]tggggctcctctcctacaacctcaaaatacctgataggccattttcccacctttataaag/a /-/4541/13/rs7986263/52570948/[g/t]/ttaagtttattggaaaagagctggaagcttctggacagactcagtag ctataattttttt[t/g]tgtggagatattcatttaatgttaactacagtattgctgtttaatattcatagactgtaa/g 50 (318) JP 2010-88432 A 2010.4.22 /-/4542/13/rs2799347/52538172/[t/g]/gaaatctgagattttaccttctttcaagctaacgtggcctgacacat ttgcaaagatgct[g/t]gcagaagacgtgggtattttgggtcagatacatggactttattactcatggcatagcaaa/t /-/4543/8/rs4735460/98456244/[c/t]/atactggtccctggaagtgacactaagggtctgagctgcaagcattca catcattaaaca[t/c]aaaggaaagtaagagcaaaggcagagttcatgaaacatgttagatgtggtgaaagagaac/c/ -/4544/20/rs6082056/212997/[a/g]/caggtgaaagcagtaactatggacatggacagaggggagggcagggcag ccaggaacccc[g/a]ctctcaaatgtccagtcagaaagagagtcgggaactcccactccttgtgtctttccagta/g/C 20orf96/chromosome 20 open reading frame 96 10 4545/5/rs4868200/172080787/[c/t]/aatggctgctgggtaggcagccaacaagtgtccccagctcctgagtt caaactttgaccc[t/c]gcctcttctgtcaccgtgggcaagtcactccacctctccaggcctcggtttccccacctg/t /-/4546/19/rs349036/49031800/[c/t]/gtgaagctgcatgtgttgggaggcgcttcagattagagagaggggagt taagtggttctt[c/t]ccaggaatttcctaagagatgaagaccagtggtctttggagtcaccaaaggactccacca/c/ ZNF283/zinc finger protein 283 4547/5/rs17132963/97957145/[t/g]/aagcaaagagatccaagaagtagataggtcttggtggtgctcacagt ggaactggagaat[g/t]cacatgcagctacagacaggtcagcatctacttcgccttctgtttatgctgaacaatagc/g /-/4548/5/rs6595959/97938006/[t/c]/ctctcctcattatcagcaatgtagtggtgcttttcatttcatggattt 20 attgtttgtgac[c/t]gtttatgttatatgtgagcatcaggtaatgggtgacaggcaagattgcaaacctgaggag/c/ LOC642909/similar to C-terminal binding protein 2 4549/1/rs943918/14598636/[c/t]/tggttacgtgactgaacccagtacacgcccccaggtgactcgtgagccc atctcaaagct[c/t]gggattggtcctaatgggtggctggctgcttgcctgttactgagagagtcctagatgtct/t//4550/1/rs12405445/14604606/[t/c]/gagaggaagcgggagaggcaatgggataaacactctggttctagagt ccaaaagacctgc[c/t]tcagcacttcctagctgtgtgtcatttgggcaagttacttaccatattaatcagcatcct/c /-/4551/2/rs721358/224075200/[t/c]/tgtctaaaatacatgattgagttttatcatgttaagggtaagttcatt atctgcctactg[c/t]tcaaactcagcgataaaaatagtgcaaagaaaaagatgtgttgaaatataacactatatt/c/ 30 -/-/ 4552/2/rs2894511/224174071/[c/a]/atatgctcatctttaaaatcattatcttggaactgcactttgctgta aagttgaagcaga[a/c]tactcattgcagttgtttaaaccacagcctaagaagtgctaccctttgcttaactattca/a /SCG2/secretogranin II (chromogranin C)/ 4553/12/rs1495653/25957139/[g/a]/taataaggacccatcatttcagctagagagcaatatcaaagacacaa cttcaaactcagt[a/g]ccaggtgaagaattaagtaaatcaataacaaaattatctggaaaatcctcagatatttgg/a /-/-/ 4554/6/rs6942280/42225344/[a/c]/agattcaatgaaagagtgggttaaggtgctcagcagagggtccagctc atggtagatact[c/a]agtacctgtgtgctctgtccccctaccttgtaggtagccaaagctccctaccctgctttg/c/ -/-/ 40 4555/19/rs189445/49023550/[t/c]/cggctggctttactggggcccgactggaaccggcagtgagggtggggg tggcatcggggg[c/t]gctggaggtggggagggctgggtcacggacagagcgtgtcgtgtccggatcctcaagcct/t/ ZNF283/zinc finger protein 283/ 4556/6/rs9486920/109135395/[t/c]/gtgtctattttttcaccaatcccacgtgcagcacaatgcctgtttac acagcaggcactc[c/t]gtcaatgtgtacctcaaggaagaagcaatgaatggaccaatgaatgtgcttgctcttgaa/c /-/-/ 4557/5/rs30094/52458935/[t/c]/gtgacaagaaacagagaatgaattaggtatggctaaaggcagtgactgga agaaatagaa[c/t]ctttatatatgtatactccactgaatgggggggctgcttagtaactctaatgggatattc/c/-/ -/ 4558/11/rs2510044/77586662/[a/g]/ctaagctcagccctgtcccctgttccagaggaggagccaccatctag 50 (319) JP 2010-88432 A 2010.4.22 cgccctggccagc[a/g]tggtccagcacctcccattggagctcatggatggtgttgtccggaacctcagcaatgatg/a /USP35/ubiquitin specific peptidase 35/ 4559/19/rs1047854/1432481/[t/c]/gaggctggagcaccccaaaagccaggggaaagtggagggagagaaacg tgacactgtccg[c/t]ctcgggcaccgcgtccaacctcagagtttgcaaataaaggttgcttagaaggtgctcagt/c/ PCSK4/proprotein convertase subtilisin/kexin type 4 4560/14/rs4901140/37255412/[g/a]/taaaatggattaaaacacatgacccagatatataatatttacaagaa acaaatttaaaac[a/g]taatgatatagccagtttgaaaataaaagggttaaaaatacacaaacaccattcaaagaa/a /-/-/ 4561/1/rs4920552/19036154/[c/t]/ggtacccatggggcatggtcattctggggactggagatgatgtgtgaa aagtacctggca[c/t]acagcaggtgctccttgaaaggcaattctttttgttattgtatataaaaggcatcatgag/t/ 10 -/-/ 4562/18/rs7244407/60272693/[g/a]/ggggggaaacaactttcaacccattctaccatcatgcaagcaaagac agttgagtgaaac[g/a]tttaaaggatataaaggaaaaaatagtaaacagcaacctagaattatatatacagcaaga/g /-/-/ 4563/8/rs10086002/10429327/[t/c]/tcttgaccagaaaacattaactgtcctccctgattagagtttgttat aatactccattta[c/t]tctagtcacctctcaaggatcatggaatgagacatcatctctccactgaagactgcttgc/t /UNQ9391/tryptophan/serine protease 4564/5/rs12659024/45453447/[t/c]/attgcctccagcaggtgactggaaagaatacagtgtgatattcttaa ttgtgatatccaa[c/t]ataaagctgagaattttttagaccttctgaatgtactcaaaaatataaataaatataaca/c /HCN1/hyperpolarization activated cyclic nucleotide-gated potassium channel 1/ 20 4565/7/rs7792748/139655801/[c/t]/actccactatgactggggtccttataagatcaggaaacagagacaga gatacacacaaca[c/t]agagggaagacaatgtgaagagatctagggagaatgtcccgtgatgacggaggcagagat/t /-/-/ 4566/1/rs2095904/9369958/[g/a]/tctgtgtcacgacgtgggtagaagctggggccacaggaggctttcactc gctcctcttct[a/g]acatcagtactattgaatacttgggcagagaggcattttcttcttgctttgtgcactgtt/a//-/ 4567/6/rs12203803/22120215/[t/c]/cccttgcctaaagctgtcattttacctcctctacaggaaataagcag gatgtagggcctg[t/c]tggtttttgttggtaatgacctcccacagcaaccttttctgttctcgcaatgagaaatcc/t /FLJ22536/hypothetical locus LOC401237 4568/14/rs6571751/20840570/[g/a]/acagcccctccatcgtttaaggagcatgcgacaaatgaaaacagagg 30 tgaagtagccagt[a/g]aacccagtgaactgtgagttcttctcatttatcccatgttgttattcctgccactttaat/a /RPGRIP1/retinitis pigmentosa GTPase regulator interacting protein 1 4569/10/rs2447027/14043369/[c/t]/tctggtgtggtgatgagctcatacccttgagaatgaagaaaatttcc atctgaggctggg[t/c]ggtgaggcttccaaaataggccagctggttttcaaaagggccagtggtgggtatgacagt/t /FRMD4A/FERM domain containing 4A 4570/8/rs4404876/10440498/[g/a]/aacaagcagttttcagaccagcagtagtccctgttccacacttcagaa gcatttccctac[a/g]agacccagactttaatcaccaagaaatagaggccacctggctaccaagcccaggctttct/g/ LOC346702/similar to hCG1643218 4571/1/rs10493454/69432428/[g/a]/ttgcttgactcaagggtcctaaatgaccaaggctttttacaaaatat tgtcatctgtacc[a/g]tcaagaattttggctgtgtaccttttctaagagtgttgttctattatcttttgcattttg/g 40 /-/4572/8/rs6474040/49202234/[t/c]/tggactgggaggcctgaggcatgagccatgccagcagcttgggcatgt tctgcattttgt[c/t]actttcttccttcatccatgttttgggtccagagcacaacctcctctcctagtgcctgtc/t/ -/4573/13/rs9319107/84509744/[c/t]/aataatatagtcgtacactagttcaaacattttatatttcctcaaat gtttcctttaagt[c/t]ttactgattatgagcataaaaaccagttttactcaaatactgtatgacatgttactatca/t /-/4574/3/rs11712251/28201212/[a/c]/atttggaaataattttggagtttactttctctattctcctatatcct gtaagaatgcctc[a/c]tacaatagctgatgcctataactggctttaatgaaacagaaatcagtgtcagattttaaa/a /-/- 50 (320) JP 2010-88432 A 2010.4.22 4575/1/rs6679498/209779313/[t/c]/cctgtcctggaagcacatacaccaatacaacacctcctaacaagcaa gtcccattcagtc[t/c]tcaagcaaagttcagctcccactctgcacctctgcgacacccttgccttcacgtgaatgt/c /-/4576/19/rs2218396/33928232/[t/c]/tttacattaatctctgagtgttcttggcctcattgaagacccacttc caaaaattagaca[c/t]cttctcagaaattgggaggaatataattttttgcttcaattctcaccaaactgcccagaa/c /-/4577/19/rs379758/48990002/[g/a]/aaaaaatctattcattttccaactccttgcactacctctgccatcatc tcttgcctaggt[a/g]tatcatctctgcctagactggggcagtagccacctcacaggtctagcttccattcttgcc/g/ -/4578/2/rs10191970/39606453/[a/g]/acagttctcaccatttgtgaccaccttttgaccaggcaattctacct 10 gcctcatgtccct[a/g]gccaaaaggctagtcccctttgtcatctattctttttcagttccttgcccatgtactgca/g /LOC728730/hypothetical protein LOC728730 4579/19/rs3764561/15585294/[a/g]/aatgaagagggagaccctccaagggcagccatgggatgcggcaccca gctgcgcaaaaat[a/g]cacatgagttcttcttcctttgcagttcatgctgagatcaccaacacatgggaccacaca/g /-/4580/19/rs8107048/15591767/[a/c]/gaggctaataatcctcactaaaaggtggtaggagcatgtaatggact catgtctctgaca[c/a]ttagtaggtggtcagaaggagtcaatttccacatttttctcacagaagccctgtaaactc/c /CYP4F8/"cytochrome P450, family 4, subfamily F, polypeptide 8" 4581/14/rs242400/55729825/[a/g]/aaattagcaatcatggccacaatcacggttttagcaaaataaattctt gtcaaatcagat[a/g]atgggttaaattcaaggaggaggtagcttcaactgatcgaggtaatagagaaaatcagca/a/ 20 PELI2/pellino homolog 2 (Drosophila) 4582/11/rs2511188/77598578/[c/t]/cctcctcccccacttcttccttctccgttctctcctccttcccttct tcctccctctcta[c/t]cctttcctcctgactgctctgcccaccagcttccttggagtccaggccttcgatgtacag/c /USP35/ubiquitin specific peptidase 35 4583/1/rs11800413/235069500/[g/a]/atggcagtcttcataatagctctgccatagaatcagggtggggcac atgggaagcttcaa[a/g]tataatgatcgttcatctctgtgatacactgattattgtcatgttttatacttcacataa/ g/MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 4584/4/rs800421/24395009/[t/c]/ataaaaaacttctaaagagtttttccaagtagttgtagcatttcacagt ctcactattaa[t/c]gtatgaaagttctagtcactccatatccttgcccacattgccattgtcagtgtttttatt/t//- 30 4585/14/rs7153837/24542222/[a/g]/tgacaaaagaagcaagaacagcaagatcagagaaaagctctggccag tttctttctaaat[g/a]acctctgagctggaggggaggagaccagttgttaagcctaaaaataaaggaagctgtaga/g /STXBP6/syntaxin binding protein 6 (amisyn) 4586/22/rs134585/27795869/[c/t]/ctgttgtacaataggaccattttcatgggcgtgcaacctgtatatcaa cataggccccct[t/c]gcttggaagggccccacacatgctttatcttttcatcttctgctgtcactgtcttgaaat/t/ -/4587/22/rs134665/27825079/[a/g]/ggtcaggtagttaggctggtggatttcatggagcatgtgaaaggagaa gccatcctgggc[a/g]aggattttcacttctcttgttgaggcttttcaggaataggaatgctgatttccttagcac/g/ KREMEN1/kringle containing transmembrane protein 1 4588/12/rs12579818/92876840/[a/g]/acttggaatgtaaactgatatctcttgggggaaaggaggaaggtct 40 ctacctacaaatat[a/g]agcatttgactctggggaagataagaaaggtattattattatttgaatgggagtagatgg/ g/-/4589/8/rs12681370/144886230/[g/a]/cacaggttcctgaatgttggccctggctaggaaggtgcccagagga gcgtgcccctgggc[g/a]ctgacaggatggatgccggccagctggactacatgggtgctagccggagccacttggctg/ a/FAM83H/"family with sequence similarity 83, member H" 4590/1/rs2859228/170879864/[g/a]/gagagcctggatggggcaaggtaaagtgcattgtaggattgagggtg tttattggttaga[a/g]gtctaggaagaggcagctgaaccagtgagtcatatatggacagctgtcctggggatggac/a /-/4591/5/rs3913348/20983113/[g/t]/gaatgcaatacccattgcaacaccagaaagttttttttgtggatattg gcaaattgattc[g/t]gaagtttctatggagagacataagacccaagatatgcaacataataataaaagagaagaa/t/ 50 (321) JP 2010-88432 A 2010.4.22 -/4592/9/rs386880/6134333/[c/t]/gacacatgaaaaagaataaaaaacaacttagaaggtaaataaattaatct aaatgaattt[c/t]gactgtataaaacagccccagtaaagttttagggcatacacactgtgtaaatgtaaacag/t/-/ 4593/10/rs10508415/10747950/[t/c]/gaagccaaggccatgaagcttataatagtgtttcacccaccgtgcc aaggcccggtgata[c/t]gaagagtcagggactttctcagcaggcttcatcattctcaccgcttgcaaagcagagaaa/ c/-/4594/9/rs662454/102874693/[a/g]/acgctgtgccacaagtaatgaagttgagagagaaagattaactgaggg aatagagaggaa[g/a]agatgcattcagtagatgctgggcaagtggaattggcagtaaaattgctattgattgggc/g/ RP11-35N6.1/plasticity related gene 3 10 4595/9/rs632924/102872718/[t/c]/tctaggactaaggattgagcactggctacttcctctgtctgcctggtt catatcttccac[c/t]cgaagtgataccttctcaataacggcctaccctggtttcctcgtttaaatcatgatcttt/c/ RP11-35N6.1/plasticity related gene 3 4596/15/rs4238458/71037538/[c/t]/taaggcctcatctctaaaaaaaatttttttagttaaaaataatcagt atcagattaaata[t/c]aggcaggtattatggggaaaatctagaagggttctgcattcagatttggcttatgaaaca/t /-/4597/5/rs2162804/63660182/[a/g]/ctctctagcatacatgatgagcatgaaaataccttttctctaacttgt atgctggttcgt[a/g]ggtgtgcaattgggaagggagttagagttgcaggtttaatagataacttcagttgcctag/g/ -/4598/9/rs2279619/539518/[c/t]/agctgttggagccagaataggaaaaggaaggaaaaaactgtcctccctaa 20 ggactgctag[c/t]tttttattttgaaggaaggaaaactgcttaacatgaacgggaccccgtcttgaagcactg/t/KA NK1/KN motif and ankyrin repeat domains 1 4599/13/rs7997435/36009150/[t/c]/ttaagttcaaaggacaatttattttagtcatattcactcatgtcttt gattacagcccca[c/t]tgatgtttgcagttttcaaggactctcaacgctttcttttccatgtgtttcttgttcatt/t /-/-/ 4600/1/rs332833/61476951/[g/a]/gagaagacctaagtttggcagcgcactaagttgaggatgagaaaagaaa aaagaaattct[a/g]tcttttctggtgcttttccctcttggtttctccactaaaaatcaatagcgtggtcgatag/g/N FIA/nuclear factor I/A 4601/6/rs7749023/42169711/[c/a]/acaggctccccaggagactgaggtttgtgtgcagcaagtttgctggga gtgccctcaaga[a/c]gcacactggcatgggagagggagaagtgagcacagggaaaagctgggctgcctgcacttg/c/ 30 -/-/ 4602/12/rs1362599/14793360/[g/t]/actgactggacttctcagctccgttccaggcttaaattgatagctta tatttaatgctct[g/t]tgggctcttgtgcacctagcaaaggttggcatggccctggtcctggtatggaggctgcca/g /-/-/ 4603/2/rs2001872/137238514/[a/g]/agcttaagaagttccctaaatcaaaggtgtcaaaaaccagaagggtt tggaacaagtgtc[a/g]gagagtaagcaaacgactttctgagctgtgactctgctcctcgactgcccacgtgctctc/a /-/-/ 4604/5/rs10514865/58711295/[g/t]/aatttgggatattaaaatatttatattcaaagatattcaccgtaaaa atacctataatat[g/t]gagaacctaggtatattctatgtatttcacatgaactaatgtttaaataaattttcatat/g /PDE4D/phosphodiesterase 4D/ 40 4605/8/rs2247105/98429971/[a/g]/aacagttatgtaggctgcaagcacccacagcagccctataaaggtagc catgcttcctac[a/g]aatctgagagctgcagagaatgaaacacccctctcctgccctgatgcattccagatttgg/a/ -/-/ 4606/5/rs40512/59841224/[t/c]/tcctaggattttttctctcatttcatctttctttcccttcatccaccttt gacttcacct[c/t]ctgcttcttggctacacttctggccttgcatgcccacagcttctgcatttttctctccca/t/PA RT1/prostate androgen-regulated transcript 1/ 4607/3/rs9854418/187759087/[c/t]/agcagaaactgtagcgtgtccactgaaagctgtccaagaagaaaata aaagatgaataga[c/t]gttttaaaacatcaaccactagtctaacaactaagtagacatagtaaattcacaagttgg/c /TBCCD1/TBCC domain containing 1/ 4608/3/rs1549599/37506369/[g/a]/tgcccctcccctgtccaggtgtgctctcaccattactccatccacaag 50 (322) JP 2010-88432 A 2010.4.22 tcgcacgcttca[a/g]tagaagtaaaaattgccttgctgagaaaattaaatttatgttcaagtgctatttcattgt/g/ ITGA9/"integrin, alpha 9"/ 4609/20/rs1535882/1548524/[c/t]/gccatggctcagtgggcaggaaaaaagattttaaccgaaggcagtgct cacctgtgagtc[c/t]ccccagcagtagcgtcatcagcaggaaaggactaggaaggtggggccaggaggctggcac/t/ SIRPB1/signal-regulatory protein beta 1/ 4610/8/rs2679768/98430864/[a/c]/cattagcagaaattaattatctactgctttcaacactaaggattatgc tgatctatgcaa[a/c]ccaaaaaagccagaaaacctgaggggtcttgacaggaggctgctgttctggcaggtagaa/a/ -/-/ 4611/8/rs4520131/98426257/[c/t]/aagcaaaataaggctaaataacacttcactcttggctgaaaatttgag tccaaaactgaa[c/t]gaagaacttagatgaacaaaatgaggtcatagggaggagtctgttcctacgttgaacaaa/c/ 10 -/-/ 4612/5/rs4394088/59663312/[c/a]/gctcaccctgtggggaaggggaaggcaagaggagggtttaattaggat cctctgaaatgc[c/a]gggctgggcagggaatattgttgctcaagtctaagggcagtatggtttagaagtaaattc/c/ LOC653198/similar to phosphodiesterase 4D/ 4613/1/rs3753472/201398156/[g/a]/aggagaggtagacagtgatagccctagacaggagagagggaggagac ttctagctacaga[a/g]gtgggtccctcccctcttctctcctcacccctcacccttctgaccacccagagcccccgg/a /ADORA1/adenosine A1 receptor/ 4614/10/rs11101435/49587067/[c/t]/agccttttaaaagagaagcagcaacaagtgaaaaaaaaacaaacaa acaacacccccccc[c/t]cccaaacaggctttagtgtgaaagtttgcatttcaacttgacgtctagctgcctgtatgc/ t/C10orf64/chromosome 10 open reading frame 64/ 20 4615/9/rs4842152/136786830/[g/a]/aatgacccgataagccgcagtttggcaggtccgagggtctatgcagg gatctgggcatga[a/g]acagaggcctgggctggataattccaggaggattagcagctctggaatcgactcttggta/a /COL5A1/"collagen, type V, alpha 1" 4616/5/rs37692/59758639/[c/t]/aaattatttaatcttagaaaggaagagtggggaaaataatcaggaagatg aactaagatt[t/c]aggaataggtaggacaataccaaatagtcttaacgtaaatgtaattggaatcctagaaag/c/-/ 4617/2/rs1075454/68195947/[c/t]/aaattttaagttcttcaaaatcagagattgtgtcccacccttccacag atcctgaagcaa[c/t]gctgggaaatagtaactaaatttgtgttgagcacataccgtaggccagtcacagccctaa/t/ -/4618/11/rs7107174/77675584/[t/c]/cccatgatacaaaaatgaaaaattgctgttggattactgacacataa 30 tgcaaggagaata[c/t]gggacatgagtcctgaatatgctattaaagagaaagctttttcaggactgttctaacgtc/t /GAB2/GRB2-associated binding protein 2 4619/15/rs11856413/72986945/[g/a]/gcactctgagtctgtgtgtggtaggctatgtgtcagggctcttgac ttctctagccccca[a/g]gggatgtgcttgtgactggctggaaagaaactccagatccttgtagaactcccaaatctc/ a/-/4620/2/rs6728104/224096725/[g/a]/tgagccccaacctaatcaatataatcactatttttgtcagcactgcc ttttgttttctta[a/g]catctactaatcagaggaagatggttgtttatttccactggttccatcagcatttaactt/a /-/4621/1/rs7525122/25267340/[t/g]/tcttccaattttttttccatcttttgatttttctccccatccagaaca ctgcactgtact[g/t]tagggcctggagtttatgaggctccaggccctacactggcttttgggcttgtatggggta/g/ 40 -/4622/14/rs10151365/50837158/[t/c]/accatactctgatttgcggggttatgaaggtctacaaattgttaga tatctttctgcttt[t/c]ctcattagacaagccagcttaagacaaatgccaaacaaagcccttgaatttcccagtatg/ c/-/4623/14/rs4981223/20041624/[g/a]/ggatcaacattgtaaccctcctggttttattcacccagagtataggg actgataatgata[a/g]tgctgctttggatagtctcctatctagggctaaatgatcagatttgcaaaatccagatat/g /-/4624/11/rs1893447/77650830/[c/t]/ccttcagagaattatgtagatctcataattccctaggcaaaactgga gctctttgaatcc[c/t]agcctagccatccacactataccagtttaaggtgcaatcttgtgattattgccgctgatc/c /GAB2/GRB2-associated binding protein 2 50 (323) JP 2010-88432 A 2010.4.22 4625/11/rs2450129/77618033/[c/t]/gtagaacacaacctggcaagttctagaaactcgaagctgctcaggct gcagcaagcacat[c/t]agaaggcagggctgagagaagacactggaggccaggccaggactaaagggaacggggagc/c /GAB2/GRB2-associated binding protein 2 4626/5/rs789615/59774233/[c/t]/aataataaataaatagccaatacaatattaaaggccaaaagtaagggtt tagataagcac[t/c]ataaaagtgggaatgtaaagcaaagcctgggtaacagtagaaatcagagaacattgaaat/c//4627/2/rs7598826/100839866/[a/g]/gggcaggtgatggagagtggtagggcgtgcatttctgccagaattgg gagtggctggtgc[g/a]gcatggataggacaggctgtccaagcacaagcttaagatgttgtcattcctggccgggca/g /NPAS2/neuronal PAS domain protein 2 4628/2/rs1371552/224074704/[t/c]/tccagtcctactgctggaccaacctatcagcagtacttgggttaaaa 10 atccaaccaacca[c/t]aaaattccacagaaactgaagtacttggcaaataccgttcatgtgtcctggtctgcaagc/c /-/4629/17/rs4889875/76266095/[t/c]/tttgctgggcagttttctcttcctcaacttgttaaattctattcatg catcgagtcttgc[c/t]gttgatgtcattttctttggaaactgttcctaaatccttaatcctttctaccttacaaaa/c /KIAA1303/raptor 4630/18/rs3850809/3888792/[a/c]/taagaagacaccagagaaaaatcacgctttccaacatgaactagaaat aaagttattcat[a/c]tattattattattattctccaataagacaataattgaaaccatggaagccatatatattc/a/ -/4631/11/rs2301160/1053767/[c/t]/caacccaacttaataaacacacggtatactatttcctgctattctttg tcctatgtttcc[c/t]ggttattttgataatgtactttaccactgtggccagttcttctcctgactctttcacata/t/ 20 -/4632/20/rs6044421/16770692/[a/g]/gtcattcttctaaaacaatttagtttcctccatggcaatatgaattg caatttgtgaatt[g/a]gaagaatcagatttcaaaatttttttgaacctaataattctattttatcttttaattctg/g /-/4633/20/rs6044417/16765706/[t/g]/gaatatagatgccagactcagtctttatgacagtgcaggcttcctta cggctgcattgag[g/t]atgtctaaagtgatacagttctgtaagacgacctttctcataagagcaacttcattattt/g /-/4634/20/rs6135909/16740200/[g/a]/agctaatttaagctttgtcatgctctatgaggttagtattatcatct ctgcaaaataaga[a/g]agccacttttgggcagaaatctataaacaggaaactttttttactgaaagaaaagaagag/a /-/- 30 4635/5/rs42301/103248266/[c/t]/ctaatatattaggaaaagctgggcttgacttgatggtttggaaagacag atgatttagaa[c/t]aatgtgcatgaactaagattgaaggcactatgtgaccagaggcatctcggtagatgctca/t//4636/2/rs1401568/134709392/[t/c]/caactctgactgcaccttagagtctcttgggattgctttaaattata ctgctttcctggc[c/t]ctgtgtagaccaattgaattatgatcttggggagggctaccatttgtatttaaaacgtct/c /-/4637/18/rs3889622/60289608/[t/c]/agcacatttaaggtaggctaggctaagctatgatgtttgctacactg gatacattaaaag[c/t]atttttgatttccgatattttcaacttcagtgggttaactggaatataatccaattacaa/t /-/4638/10/rs2211084/86796037/[g/a]/tctaccctctagcagcttacagctcatgggcatggacatgaacagct 40 catacaatgtgac[a/g]aaagtgtgattaagggacaagatccaagtgctacttgaagttagccatgttaaccacatt/a /-/4639/2/rs4392257/107081285/[t/c]/cgccttgttccatcccattcagaggctcagtccaaatggaccccata gagttttcagcaa[c/t]gattagtgaatgattctgtctcctgtcactagccttctgcaactgggaagaaccttcccc/c /-/4640/2/rs2302561/71075330/[g/a]/aacgagcaccgatgccggggcgggagcccgcgcgggccggggtcgtgc agtctcaccgac[a/g]gccagcgtgatgaaggccacctggatgaagagcgacagccagctcagcaggtacatgaac/a/ TEX261/testis expressed 261 4641/16/rs5882/55573593/[g/a]/cttctgtgctccagggaggactcaccatgggcatttgattggcagagcag ctccgagtcc[a/g]tccagagcttcctgcagtcaatgatcaccgctgtgggcatccctgaggtcatgtctcgta/g/CE 50 (324) JP 2010-88432 A 2010.4.22 TP/cholesteryl ester transfer protein 4642/19/rs4280366/33917635/[t/c]/atcttgttgagtttctttgccactcacactctgaattatatttctgt catttcagacatt[t/c]ctttttggttagaatccacttcttgggagctagtaagatactttggaggtgacaaaacac/t /-/4643/19/rs2870526/33918744/[t/c]/ccctgctccagggcaaatggtctactctctggcctgagactaaaatg tctgcagaagaca[t/c]tattgccaggttgccacacaatgactgccttggtatgagcccagattaaaaatagtatca/t /-/4644/12/rs11113836/107274251/[t/c]/cttttgatctggttataaaaaataactggagaaaagcaaaataaa ttgcaataaacttga[c/t]gccaaaacataaaacttgctattgattttataagagcaagctatgagctcagacaaatca /c/-/- 10 4645/12/rs2280697/51804087/[c/a]/agggcctggcttgggggtgatggactctcacgtcttggatgcatggg ttgagtcaccagg[a/c]atgatctcattcacgacttattcttctctggctcaggcaactttctgggggctggtgaca/a /SOAT2/sterol O-acyltransferase 2 4646/7/rs7800262/139672377/[c/t]/ctctcctccctccactgactcaattcagaggtctggagacataaaga ctgaagaaaaagg[c/t]ggacagaagctaatttaagggagtgagatttcgagtgaagttaaggacccacgtcttctg/t /-/4647/1/rs514163/164151771/[a/g]/agcacaaaatcagccaccactcactgggcagctcttgtgccaacactg tcctgccactct[g/a]cctgtaaagtctcattcaatactctaggcaaaacaaggaggttagccctgggttatggat/g/ -/4648/1/rs7515225/48779373/[t/c]/tgcttgctacctcccacctactccccttgcccttcacattccagaaac 20 actgagcttctt[c/t]tgcctccaggcctgtgcccatacatgccatctttctagatcactcttcctcccttcacat/c/ -/4649/6/rs10499303/155656931/[t/c]/tactatttttaacatatgggtcccaactaacctagctccatttact cacaagtcagccct[c/t]gttgatccctgtcagcacctctgtcagcattggtctggttagatacatcatataagcatt/ c/TFB1M/"transcription factor B1, mitochondrial" 4650/14/rs1952629/33805185/[c/t]/acataaacgccatggaagtagactatagagctgataaccattccctg gaggccactgaag[c/t]ccacagtacatggacatggcagtttgaggtttttttgtgacaggatccggtttattctgc/t /-/4651/12/rs1118582/43827201/[a/g]/ttcaaaagaaaccataaacattagtttgatggaacaattgtccagtt tcaatttgcctct[a/g]ccaaagacaatgttcctcagggagtctgttttattagctgaggtcctgaagtaaagacac/a 30 /-/4652/20/rs2209313/1547142/[t/c]/ttggaaataggggataatagttgcagctttcacacagggatgttgtga ggattagtggag[c/t]taaaacaggcaaaatgctaataactgtgtctacatggtaggaagagctcaattgttaaac/c/ SIRPB1/signal-regulatory protein beta 1 4653/2/rs2118891/212387888/[g/a]/gaaatcagaggtgtaggcacagcacctgtggtgtttccatcagtttg taatggtgtattc[a/g]tgtgtataaatgtggcatatgtaattaaggtcctgtgccatagcaactgtaagcacaggc/g /ERBB4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 4654/7/rs2350835/9425020/[t/g]/tgagctttatccatgttgttgcaggtattggctgatcatttcatgttat ttactacctaa[g/t]attctgttgtaaggacacaccacaatttctttattcattcatctgttagaggacacctgg/g//- 40 4655/7/rs4509227/9413865/[c/t]/ggaaaaaagtcacaaggttgctgagcgtcctaaatggccagtgagaacg ctggacaaaga[c/t]aaatggaagagataagaaggaccctttgatagaccctgatctctctttccacagcatttt/t//4656/6/rs9450431/87132204/[t/c]/ccaatccttcttgttcattaacttttgaaatgtcatatgccattgcca ataactggatgc[c/t]ggatatatgtctttcagtctagtgagattaaaaatgattagttcaaagtgcttaacttta/c/ -/4657/5/rs1355096/10279025/[a/g]/tgtgtgactttagtgggagggcagctcttgctctatgcctctcagttg ccttccactgta[a/g]ccagtcctgtaactggtctgggcacactcggagggggatccatggtagctccttgccatg/g/ -/4658/3/rs11720453/103897817/[t/c]/tacattcttctctttggggggtccatactttaggcagatgaacttt 50 (325) JP 2010-88432 A 2010.4.22 agagaacaacttca[t/c]cctgtggtttgggggagacagacaattaagagttggtgggagatggggtgggtggtcaga/ c/-/4659/3/rs1589287/103892606/[t/g]/ttattgcttcttccttggttcttgaacctatggaataattctgagct gcatcagtctaag[g/t]gttcttcttctgatgaatgtatgcttttgaaggggtgttgatctactaagacaagaaagc/g /-/4660/3/rs1609976/103881839/[c/t]/tgaataactaggaaaaaaagtcaaccactggagaaaagaagagcctg ggagtcatcagta[c/t]acccagacaaactttttctctattctccttctgcagctccaagagactacctggggcact/t /-/4661/10/rs1933938/86696661/[t/c]/aaaataattggcctctatgtctgaaatcatcacagaggcttaaatgc cactgctaggtgg[c/t]caaaaatttatgttgaatgttctcgtggatgaattggctttatacccagagttagcagtg/c 10 /-/4662/10/rs6585903/86638705/[c/a]/agaaatctatataacaaatcaataatagatgagtgctcttagaaaat gcaaactgaacta[c/a]ggctgggttcactaatctgcccactaaatgtagttcagagggttaaattcaccctgcctt/a /-/4663/2/rs2138648/45151924/[c/a]/aggcatcagatttcagatgttcacatttgtcctttggtggtccctgta tgagacctctct[a/c]aaggttccgtattttgtggcacttgggcacctggcagggtttggaggctctgctgagaaa/a/ -/4664/13/rs7997510/50921534/[a/g]/ctttcccgcaaacttttggtaagccttatagacaagaactaaagtgt tctctgggggcag[a/g]tatcaactgggaaaaggaaaatacaggtttaaattacaaatgtcctcagcctctccatga/g /INTS6/integrator complex subunit 6 20 4665/3/rs9831010/28308600/[t/c]/tcagtctacttctctcaaaaacaaagagtgtttttagcgggaatttgc aaggtattttaa[c/t]tcattttctttccccagtgcattctaggagctaggatccatggcatgttgagccttgcca/t/ C3orf68/chromosome 3 open reading frame 68 4666/13/rs3024718/112861854/[g/a]/acatgctttgggaccctcaggtgggaagaggctccagagaccactg ccgcgggtcaactc[g/a]tttgccttctcctcctggaaatcgcagagcctgctgcaatgtataagtttcttctttatg/ a/PROZ/protein Z 4667/14/rs242413/55697554/[g/a]/cgtgtgattctagtcatggaaccttaataacagtcttctatgccagac ctgtgtgacaac[a/g]taagttcatcttccattatcttacacatctctactggctgttgagaggtttcatatttct/g/ PELI2/pellino homolog 2 (Drosophila) 4668/9/rs4563961/136809823/[t/c]/tgccacgccgtggtgagacggcaggtggttttctggggcccccagct 30 ctgtgtcagccag[t/c]gtggccctacctgttctcttttcaaaactctgggggcttccagccaggattgctttggaa/t /COL5A1/"collagen, type V, alpha 1" 4669/16/rs1865975/64942283/[t/g]/ctcgcggcccctcccaggaggttcaggttcagcggggctggctgggg ctgcagcactgtg[g/t]tttttacaagttcctaggtgactctcgccatcaggagacagaggagccctgctgagtggg/g /-/4670/1/rs1341511/64263481/[g/a]/gagctcacattatacgacttctagaggtcattcaacttggagattccc tgagtctaggtt[a/g]tggagaaaagttgtctctggcaccagactaatctgctgcccttcctaggggtggaaatat/a/ ROR1/receptor tyrosine kinase-like orphan receptor 1 4671/17/rs7208502/76284923/[c/t]/tattaatccaagtaagcagaattcccatgtagattcattccacagcc ttttcttgggtga[c/t]gactctgtgcccagaagcaaggggctgactgggacctgagaggcctcttcttagtggcca/t 40 /KIAA1303/raptor 4672/2/rs10196805/67169754/[a/g]/atattgatatggcagaatttgtctattttactgttgttggacatttg agttgatgagtcc[g/a]ttgaattttgtatctttacctaatagatgtgcttcattattatttctaatagttttccta/a /-/4673/8/rs7812549/19751449/[g/a]/aagtacatttttatttgtggatactcatatgagtgaccagtcattatg gtcatattagca[a/g]ttagttgcctggtatctaaataggcactaatgtgttttttttcctgctactgatgttttt/g/ INTS10/integrator complex subunit 10 4674/7/rs2350842/9400633/[a/c]/gtgtcagaactctctgtctccttctctcatctctctctcagaaggattc tgagagtcatc[a/c]atgtttgaatcatatgcaaaaaataaaaccaatcaccgttgagaatcagggtatcttaca/c//- 50 (326) JP 2010-88432 A 2010.4.22 4675/8/rs2261824/140676724/[a/g]/ccttggagcctgagttcaagagtgccagggccaaccaatgactttct ccaaagatgcaaa[a/g]tatccaagaatgcagggacctgggggtccccagaccttggcttgactccttgcctggcct/g /-/4676/11/rs4758331/8285806/[t/c]/tacatttccaggatctcagaaaccttatgtatacccctttccagctgt attctcttcctg[t/c]tccctaggaagaggtatccaccactctgactcttagggcagaggtccccaacccctaggc/c/ -/4677/12/rs4128893/94647740/[c/t]/aagagaaaagctgaggttactgatagatatctgacttctggtgcaca aatcgtgtctcca[c/t]ggtatttcatttgtgtcttgccaattttgtaatagctggaagcatacttcaatttgtcct/t /NTN4/netrin 4 4678/9/rs11103509/136793924/[c/t]/actccatcggtcctgctgatggatggagctcggggccagctctcag 10 ctctcactgcagga[c/t]gcaggtgccccaaaccccactgggaggaaaggtggccagagcgtttactgagctcagcgt/ c/COL5A1/"collagen, type V, alpha 1" 4679/9/rs3109676/136771019/[t/c]/tccttctgcactcaaatccacattcattccaacagcaggaagagaaa actcccgccccgc[t/c]ggacaccaggaggccgcagtacttggagcgcccaccaggtgtcagaaggaaatcgcggca/t /COL5A1/"collagen, type V, alpha 1" 4680/4/rs6816797/75477542/[g/a]/gacaacacttcaaaattacttactgttttacaatttacaaaatacttt cacatctattaa[a/g]tctgtttcgacacacactttgatatagaaggtaagattcataattattacctaaaaaaga/g/ -/4681/3/rs4681141/149106957/[a/g]/gaaaatgcattgcctgaaaaaaagttgacatgtatgcctactgactt tgtaaactgaaac[g/a]gctaacaaatcttggaaatgattcagaattgcctctggtaatagtcatattattagttta/a 20 /-/4682/10/rs10509507/86804174/[g/a]/ataaagctccaaatctgcagctgacatgtgaaacagtcctgctgct tcctagacatgtaa[a/g]gccccagttttaggaagctctgaagttcacagtgataagtggtgaggactaacgagaaga/ a/-/4683/2/rs10496410/107046670/[t/c]/gataaataaccttttcatatgaagcctctaggctgaaaccatttgt gtttcacatagagg[c/t]gatgtcttttagagaaatctcaggcaattagagctgatacccacacctcctttgcacgga/ c/-/4684/7/rs1882079/37357791/[c/t]/cagttctctgtactaccctaacatccttcctagatagacaaactaata aattcctcatta[c/t]gctaaatcagcttgagttgtttctgtcccttacaattgaaaaactcctaatatatcaacc/c/ ELMO1/engulfment and cell motility 1 30 4685/16/rs1123494/64953045/[t/g]/ccatgcctagcacagggctaggaaaagcctgagcaccaaatgtattt tttaaataacaaa[g/t]gaacataaaacattggtgaacaatggcaagttatcagaagaagggtggtgctatagaatg/g /-/4686/1/rs1887283/182243532/[t/g]/gttggtagaggaaagattaaagaaaaacagtagggtagagctctttt caaaatgtttgag[g/t]aacctgggataagcttgaggaccctgggggccatggccactgtgaaccaatttcacagag/t /GLT25D2/glycosyltransferase 25 domain containing 2 4687/3/rs13079598/29295837/[g/a]/ggtggagatggacttgggagagcactccaggaagagggaatgacaga agcctctgagagc[a/g]tgttcctgtcctgaaagtagctcagagtgactccggtataggatgtgaggggcagagttg/a /-/4688/13/rs3764124/112945321/[t/c]/tggtattgatttgcttttgtagacttttggaacagcgatcgtaatc 40 aatcctgagaaaga[c/t]aaagacatggtccaagacctgttggacttcaaggacaaggtggaccacgtgatcgaggtc/ c/CUL4A/cullin 4A 4689/13/rs7994324/112954498/[c/t]/cccctgagaggcatccggaaaacacgagcaggatccgggcgatggg aaaggctggtgcac[t/c]gaacgctgggaacttgaaaatgcagcaaccacaattttaaggatcagtagaaagtttgga/ t/CUL4A/cullin 4A 4690/17/rs9789000/14421734/[a/g]/ctggggggttggaatggggattacatgtaaaggggcctgggggagtt tgttgggggaaat[a/g]caaatgttctaaatctgatttgtggtcatgatgtacttcttaataaggttaccaaaaatt/g /-/4691/20/rs2268086/32112399/[a/g]/gcacatggaagattgaaggtgcactaattgtgcctttgagcactggt taagagctactca[a/g]tttgcccagtcatagtcttaggtaagtacagtagcattcaggaatgaatctggtgtccat/a 50 (327) JP 2010-88432 A 2010.4.22 /RALY/RNA binding protein 4692/15/rs11632283/35395326/[g/t]/aatagtaacaatgtattgagtgattatagcatgtggataaatgaaa tagataacaggagg[t/g]aggaattggagatactctgtaatagggtatatgtaagacacatgaagcaatgtagtatat/ g/-/4693/9/rs1329411/73419679/[g/a]/atgaggcaaccaggcccagtaacatagttctaatgggaagctcattaa aatagaaggata[a/g]tacttttttgcaccatgtctcccatagaacagaattaaaatgatgggttgttttccaaca/g/ -/4694/5/rs6869495/59686293/[g/a]/accacaattggaggttggggcattctgaaccatttttagtctgggatg ttgcccagtact[a/g]ggacgtttttctggctcaaataaatttttttcaatgtaattggtctctgggttagttttc/g/ LOC653198/similar to phosphodiesterase 4D 10 4695/16/rs8061475/11795149/[t/c]/ggcaagcctcagaaggctgcaaacccagatgataagacattaaagtt gttgaagctccta[t/c]tggatactttatgaaacagtttctcccttttactgaaaaggaaaatttcatgagagacag/t /-/4696/11/rs2513726/57555518/[a/g]/ggctggtaggtttcctcacacccatcttgccaatctacctcttgtct cagctaacatttt[a/g]tggcccaaatgtcattgaccatttctcctgtgatgcctcacccttgctagccttgtcgtg/a /OR6Q1/"olfactory receptor, family 6, subfamily Q, member 1" 4697/11/rs921135/57555299/[a/g]/tgcccaagatgctggctggttttattggggtggatggtggcaagaata tctcttatgctg[a/g]ttgcctatcccagctcttcatcttcacctttcttggggcaactgagtgtttcctactggc/a/ OR6Q1/"olfactory receptor, family 6, subfamily Q, member 1" 4698/8/rs6990880/4868194/[t/c]/tgccaccgcactccagcctgggcgacagatgttaaatcaaggttagcct 20 gaagatccctc[c/t]ttacatacgtaatttcagcctaaaggcttttctgtacatcatgaactataacaagtagag/t//4699/11/rs4944196/77686379/[a/g]/aggaggtcatggctggaacacagtaaacaaaggggaaagtagaacaa gcaaaaggcaggg[g/a]tagattgaagtttagattttatcttaaataaaatccctcaataggggcatgattaataaa/a /GAB2/GRB2-associated binding protein 2 4700/11/rs4945261/77667908/[a/g]/attatccttccccaaggaagataaaaatcacagaattcctaggttag gatatctagttca[g/a]gaatgactggctacataatttgcagagcccagtgtaaaatgaaaacgcagaacttcctgt/a /GAB2/GRB2-associated binding protein 2 4701/11/rs2511175/77652729/[g/a]/gtaaggaaaatgagaacagcttttatttaccaatctaacatatctcc acaaaattctcta[a/g]aaagtccaacattgtaactgaaaaaggtctgaattattattgacatgctgttgtgttaaa/g 30 /GAB2/GRB2-associated binding protein 2 4702/19/rs1386502/48985196/[g/a]/aggacagatccacagtattgggtctcagaaccacagacagcaactca actaacggaggac[g/a]aaagacagggaaatgaagaaatgccatcttgaacagtgtggaacaggacaagaggctaga/a /-/4703/15/rs2732026/22767581/[a/c]/ctactctcgtcgcctttctcatgaagttttgttttcttgtgctgtaa agataaatttgac[a/c]actctgcagtgatttattttcttctttcacttacaaggtcatgactacattgtatcacat/c /SNURF/SNRPN upstream reading frame 4704/2/rs2364722/177833033/[a/g]/atatttttgctttcatttacagaaaacataccattagcaattgaata aatcttggcctat[a/g]ccttaaagcccttttaataaatgtttgttggcgcttatttaaaagcaggtagcagtgaaa/g /NFE2L2/nuclear factor (erythroid-derived 2)-like 2 40 4705/5/rs26953/59850071/[c/t]/aagctgacaattcagtatcctcttctttcctggttgctttatagcccact cttagttgtt[c/t]tctttctatatttcctacaatttttagctgtgaggctgtgtattcgttgcttaaaaattc/c/PA RT1/prostate androgen-regulated transcript 1 4706/9/rs4842153/136787135/[c/t]/catggtgtcggggccatgcatatgcgtgtgttttaaggcattaagta tgcccagaagatc[t/c]gctgcagaagaaaagatggtggtgagagaggggcttggagctgaggggtcgattccaaag/t /COL5A1/"collagen, type V, alpha 1" 4707/20/rs714509/16743657/[g/t]/ttctgagagagaatttatggcacttccatggcacaaagagacaaatat ttcacatatgtt[g/t]ttgggaaccaggataaagaagaaacgggttgttatttttttaactaatctgaaggtacat/t/ -/4708/19/rs1725489/43269866/[a/g]/gagatgctcttggcaaatcaaaggctagtctaagggcaaaatactgt 50 (328) JP 2010-88432 A 2010.4.22 gtggtaattaatg[g/a]ccccgatcagaacagcatctgcagggggttcaacaatctccagctgatcagagaatggaa/g /SIPA1L3/signal-induced proliferation-associated 1 like 3 4709/6/rs9374035/108966286/[g/a]/tcgccaaactgaggcaggaggggcacaccacagagcacttgacgacc acgggtacccagc[g/a]ggaagaaagcacaagaaattctattttgttgtattagtgatctgaaaaattagaaataaa/a /-/4710/3/rs6792725/24495287/[g/a]/ttttccggatttggaaacatctccccctaccccatgagggcgaagatc atcatgatgaaa[a/g]agcagctataactgatgaaaagcttagggggtggggagagattaagaggtagaactaaag/g/ THRB/"thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) on cogene homolog 2, avian)" 4711/14/rs2354922/61972945/[c/t]/ctgtgtactctgcccagtactttgtgaatcatacacttttacagtct 10 tcctggtagtaat[c/t]ggcccatttccagccctctgtgactgttagaccctattacctctaattattgtgtgttct/c /-/4712/15/rs11634716/22857739/[g/a]/catggcccggaggtcaaagttcacatccagtgatcgaaggccaggg tcttgagccatcgg[a/g]ttgctggggggatcaggtctggaggctgcaaactagaactgcccattgtggtgttgggac/ a/-/4713/14/rs1911216/81969086/[g/a]/ggtattaccccaagggacatagagagctactaaagtgaagttgcctg cccaaggaagcca[a/g]tgactttgagcctgggtaccaatacttactatgttgcttcttctgccaggagccacaacc/a /-/4714/6/rs6927999/156913513/[c/t]/ctgtacagggcaggcaatggagccaagtgtctgcatctatacaagga ccttatgggcaag[t/c]accccatgtcctccagcacaaccctcagaccctaattaactcccccatctaaaccttagg/t 20 /-/4715/15/rs516667/100021554/[t/c]/cacgataaagagcttttatcagaaaacagcaatagcatctcaacaca gttgggaagaaga[c/t]gaatatgactactatttgtattgttactcaaaattattctgggattacaaatacatgaaa/t /TARSL2/threonyl-tRNA synthetase-like 2 4716/17/rs9905663/70397218/[c/a]/agaacgtgtcctctgcaccctgcagaggcccagatgacacagcaccc aacgccccaacat[a/c]tacacagccctgttgagctttgcaaacttgcagttaaaaaaacaacaaaaacaaaacaaa/c /FADS6/fatty acid desaturase domain family 4717/15/rs220030/22750861/[g/a]/aatcctaatttacactcaccctcaggtcttcctatgtgcggtac[a/g ]aaaaagctggtttggaaaagttaaatgcgccataaccacaatcaatgcaaatacgccaga/a/LOC647795/hypoth etical protein LOC647795 30 4718/8/rs10957053/59476240/[t/c]/aatttccctgttgccaacctataggtgactggccagagtgctatctt aagtatctcccag[c/t]ctataaggagcttaataataaagcttaaattataaatagaagagaataatatgatgatta/t /-/4719/21/rs7281682/34446885/[c/a]/ttgactcaacttcctgtccaatcgtgaaacctgttctcagggcccct ggaactcacagtc[a/c]tcagtggtctctgatcacctccacctcttctgtaaacatttcctgcttgttgctccagtg/c /-/4720/21/rs7280506/34450098/[c/t]/attatgttctttctgttcttagaagagacctgacctgagagattctc agcaaagcacaac[t/c]aataatagaattaaaatgataacagtttggattatttagcctaacagaaaatgatggctt/c /-/4721/21/rs2284612/35135749/[c/t]/gtcacctgaggtcaggtggcattttcttaagcctgttttctaaggca 40 aatgcctcctact[t/c]gaaactagaaggcagataggttgagctcccctctttgctccggcagcagtggccaccttg/c /RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncog ene) 4722/8/rs10282765/98480578/[t/c]/tgtccactgggaatgcatcctgctgtaagtaacaggcattccaactt acagtggctcaaa[c/t]aagtcaagatttaactttctcatattatgaaatatctgggggtagcctgccactggtgtt/t /-/4723/8/rs1457047/59461536/[t/c]/aacagatgtgtactaagatcatgggatttgttacttgctctaatgcat gttaccaacttt[c/t]tatttctatttgtcaaaatacattttttcttagttgaaattaatgtatgaagcatatttt/c/ -/4724/9/rs3922914/136738552/[g/a]/caggctggggaaggtgctgggacaggggctaggcgggtccaggtcac 50 (329) JP 2010-88432 A 2010.4.22 ctgtcacacacgg[a/g]agggacactcttgggccctctgcccttgctaacagcttatgctggctcttcctggaaggt/a /COL5A1/"collagen, type V, alpha 1" 4725/11/rs6590293/127414453/[c/a]/gaatttaactcaaattattgtccttcctcatgttgacccctagggt gagcaaggactgta[a/c]aatacaaaacaatgaataaacaaataccaaggccacatccgtggtatacagtggaaagtg/ a/-/4726/11/rs713069/127492127/[t/c]/tcagagcagggcagatttgaaagcatttccgaaggtgcacacagacc catcaacataggg[c/t]ggaggcgtcactagcacatagatcc/c/-/4727/17/rs3923514/76129805/[c/t]/agggctgacttgtctcacctgggtgattccatgactgtggcatgtgg tgggctggccact[t/c]ggggctgcagttccaatttccaatgtctccagttcttcacaagcaaggacatctattgtc/t /-/- 10 4728/17/rs4889863/76165063/[g/a]/ccacctactttgactgaaagacttcagaattcttttctcatgacggt ctactgatgccac[g/a]ttcacttcgttagtctgaaaatatcttttttgtttgtgtgtttttgtttttttgagacag/a /KIAA1303/raptor 4729/9/rs7045455/1813605/[t/c]/taccacaggcatcaataacaatagttccctgaaggtcttaaacttttct gattgcaaaac[c/t]gattcccatatattgacttgtttgatgcttattcatccccatgtgctaacaaagtcagct/c//4730/9/rs2361093/596676/[a/g]/atatatttatatatttatatatattacatatatatatatgtttagaaaat aaaagatgca[a/g]tatgtcagtgctttcttatgacagttgcagctacaaaggaagattaaagctttttaaaaa/g/KA NK1/KN motif and ankyrin repeat domains 1 4731/8/rs16911045/140673825/[g/a]/aattgcaagagaacgttaatatgttggtgtctgtgacgacatctga 20 actcctgaagtcgg[a/g]tgcataaagtttggatgttttgttctgcctagagtgggacagcgacccttctacccctcc/ a/-/4732/6/rs11967698/120652337/[g/a]/gtttcctattgtaatgggtactcaaagactctttctatcaaccagg gtcttcttgtgttt[a/g]cacaggaaggacaaaagtttcctatgataggtcacatacaataaaatgccttattcaagt/ a/-/4733/11/rs7124405/70568809/[t/c]/cagtgttcacgctgtaacctgcctgccacttgggaatgacaagcatc ttgctgaatttcc[c/t]ggggacaaatgtcattatcttcactttgcacttgcagaaaaacatgactcagaagcaaat/c /-/4734/10/rs686374/78837467/[t/c]/gtgccaagcttcagcttccccaccaccttaatgaggcggcatgtttgt ccccatcttaca[c/t]ggaagaggctgagactcaagggttgatgggccacagccatcagcttggaagttctggagc/t/ 30 KCNMA1/"potassium large conductance calcium-activated channel, subfamily M, alph a member 1" 4735/9/rs567900/102864509/[g/a]/aataataattgtgcaaatggggctcattgattgcctggattttagttt agccctcattag[g/a]ctacatacaggctaatattcctttaatattggtagacctgagttttgcagaataagcaaa/a/ RP11-35N6.1/plasticity related gene 3 4736/3/rs1379656/28502629/[c/t]/gtactattcctgaaacaggataattatttgtaagtgggatttgaatta gttgtaaatgta[t/c]attgcaaactctagggcaaccaccaaaaagtttttaaaaaagtataactgataattggta/c/ ZCWPW2/"zinc finger, CW type with PWWP domain 2" 4737/3/rs6445190/61045494/[c/t]/gagttttgaatacatttatatagttatacaaccatcacctctacatag ttttagaacact[t/c]ctatcaatccaaactgttacctcatgccctttgcagttaatccccactccccacaccagg/c/ 40 FHIT/fragile histidine triad gene 4738/4/rs7661111/30668113/[a/g]/aaagcacagtctctgaaatagaacaagcattgtcactttcaacagtag tgatgcagaggt[a/g]ggtcattgcatgagtctcctggtataaacatatatgaacttttctgtactggggattaga/g/ PCDH7/protocadherin 7 4739/21/rs2268284/35142549/[t/c]/ctagcaagagaggtatcatgcagtccattctacagatgggaaaactg tgaaacgcagttt[t/c]agacttgaagctccaaactcctttctcgctcaccgaggctacctgagcaccctggttcac/t /RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncog ene) 4740/8/rs4076358/144982227/[a/g]/gtcctcaacccttacatcctttctctctggagtgcccctcaaaggtc acttactcctgtg[a/g]cttcaagagaaaggacatagtagaaagagtggagttagccagtcctgtgaatcacacact/a 50 (330) JP 2010-88432 A 2010.4.22 /PUF60/poly-U binding splicing factor 60KDa 4741/2/rs11887399/226131368/[c/t]/tttagaggctttaggggaaaccctttgtccatttttccagcttctt tagctgcatatact[t/c]cttgtggaaatcagtaaatgatagcatttctgattggtttatgacccccgtcctccatct/ c/KIAA1486/KIAA1486 protein 4742/19/rs2288419/60385056/[g/a]/gggacgcctctcactcccgtgcctgcttcccaggctcagtacgtatt cctgcatcagtgc[a/g]tcctgcggttcctccaacagtcagcccaggccccagccgagaaggaagtcccgtatgagg/g /PTPRH/"protein tyrosine phosphatase, receptor type, H" 4743/15/rs705/22770605/[c/t]/ctgcaggctccatctactctttgaagcttctgcccagcttgcattgtttct aggagaacc[c/t]gcgtcatacctttatctatagccttcccctaggtcttcagaagcatcaagttttaactgt/t/SNU RF/SNRPN upstream reading frame 10 4744/11/rs621313/88553311/[c/t]/ttctagagagtattaaaattgaacacattcatgaagagagaaaaagga aaaagttctgct[t/c]gacaattaataagtaattaggaaaataatactcatacagttgtggatagcatctggtatt/t/ TYR/tyrosinase (oculocutaneous albinism IA) 4745/2/rs718159/97785966/[a/g]/actgaatatagaaaggatgataaatcttaggaataataccaatggcatt aatgtaatccc[a/g]cgtaagtttcgaaaaacctttccaagtataaattcagtaagaaaagctggcctatagtag/g/T MEM131/transmembrane protein 131 4746/2/rs7570009/97770115/[t/c]/gaattatctatgtaaaaagcatgtcctagacatttacttcgtctttat cttcactacatg[c/t]tgtgtaatgaatttgtctgagctaggtgctctgaatgaatcgttagtctgagctagttag/c/ TMEM131/transmembrane protein 131 4747/2/rs3821053/97758319/[a/g]/agggcggtcaccactctactgcttgggagtaagcggccaccaaaaccc 20 cgcttccagcag[a/g]tgctaggagcaacatgacaggaaaaacacaacctaattaaaatggtagagttccttctca/g/ TMEM131/transmembrane protein 131 4748/18/rs4625812/17525302/[a/g]/attaatagaattaaatggagaaacacaaaatctacaactatatttta aaatgcttctatc[g/a]ataaaagataaaagtgagctatagtctgaaaaacattatcaatagtaaccaaatttaaat/a /ABHD3/abhydrolase domain containing 3 4749/15/rs488156/71412948/[g/a]/cttccagctacagccctgtagctagtggcaagctgttctgatactagt gaccgaagatga[g/a]tactttttgtccacagctcatcacctgcagtcacccccacctgtggcccccatcaagggc/g/ HCN4/hyperpolarization activated cyclic nucleotide-gated potassium channel 4 4750/17/rs6565478/76306599/[a/g]/ccctctctaggtaggatgagctttgctccaggttacctgcctttcct taatttactgaac[a/g]taaagttggagttttatgtggttttgcatttttggtttaggataatttttaattcttcgg/g 30 /KIAA1303/raptor 4751/20/rs4239713/14472404/[g/a]/agttgaaaatatcattaagtcaaaaattttaagatagtattatatca aaacaccacttac[g/a]ttacaatatcagatgtctttgaagcacaagtccttctctctgtagataatacttagggaa/g /MACROD2/MACRO domain containing 2 4752/22/rs134558/27787622/[a/g]/tttctaaccaactgccatgcaccaagaagagctcattcacagggaaat caatatactctg[a/g]ggaccataaaagcaacacgaaaacattaatgctgccggcctccatttcctgggaccaact/g/ C22orf31/chromosome 22 open reading frame 31 4753/15/rs3784664/68150256/[a/g]/ctcacacaaaattcagtcaactgaatgcagctcatccacatcctgga gtgaataccttag[g/a]tatggcttcaaaatatcctgtgtattttgtgacaagctacaacgtccctcttcctctcct/g /TLE3/"transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)" 40 4754/15/rs8032946/68133223/[g/a]/cactgcctttaggacacagctccttaactcgcactccacacgccctc aatttgccctctt[a/g]atctatctcttcatcctgcatgaactatggggctgaggccatccatgaacacgctgaata/a /TLE3/"transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)" 4755/9/rs4135168/112056706/[g/a]/agggtgacaggaactttaaaaaaagcactacagcctggggcccaaag gccctgataatca[g/a]ttaatcctcaaaataacaatccaaagtcattgatcgaaagttacactaatttgattgtta/a /TXN/thioredoxin 4756/1/rs3930248/182220626/[c/t]/tgtagcggtgacagtgcacctgttgacctgggagcatcatcagccaa ggggatccctaca[c/t]gtgctgtgatcacatctccaatacgtgtttcccttagtcctaattcaattttgaatctga/c /GLT25D2/glycosyltransferase 25 domain containing 2 4757/16/rs1532624/55562980/[t/g]/gacttaatcacccatttgtcctgagttctatagacttgcccaacgcc 50 (331) JP 2010-88432 A 2010.4.22 acacagcttgtga[g/t]gctgcagcccaaaggggcagagatttgccaaagtatgctcataactaatcatcaagtgtc/t /CETP/cholesteryl ester transfer protein 4758/11/rs6592772/77693211/[c/a]/actcgatttcgccaagggccaggctcccaaggcaagaatctagagta gaagtcacattac[a/c]atcttagactctggagagacaaagaagaaatatttttcctgaagtttcttaaccaggctc/c /GAB2/GRB2-associated binding protein 2 4759/4/rs6830655/178951238/[g/a]/tattgaaaacattgtcatttagatacacactcccagaaaaagtatct attcttccctgag[a/g]aagacatacaggactgccatgggctttgtgtaaacaaagtgatttcaagctgacaagaca/g /LOC285501/hypothetical protein LOC285501 4760/13/rs2316442/112925488/[a/g]/cagaactctcttccagcaaaaacaagctttttgagagcaggacccg tgccattcatgcct[a/g]tccctggtccccaacgcacagtgctgagttggacagaaacaccccatgtttactaggtta/ 10 g/CUL4A/cullin 4A 4761/15/rs11634827/52301170/[g/a]/gattggttatcttataccttgctttaatgttccataatgctaaaaa aaataagattaatc[a/g]catagccctatcgaacaattgttttggcaacacagaaataaacagaaacactgcattttc/ a/UNC13C/unc-13 homolog C (C. elegans) 4762/22/rs4820242/35312621/[a/g]/caatctatataataaaatgcctcctacatgcttcataaaagtgatct gagggcaatggca[g/a]tccttgtgctgttgggaaggggaggtggcagggcctggagcagaggcggggttgctcctg/a /CACNG2/"calcium channel, voltage-dependent, gamma subunit 2" 4763/20/rs4809776/48352524/[t/c]/tcccgccaggcagatgccttcctgtgagagtcaggaagtgggggccg ccttgttttttcc[t/c]gggctctctttctgctggtgagcatggtcatgggatggattttcttgcagcaaccttggc/t /LOC284751/hypothetical LOC284751 20 4764/19/rs2927707/8276921/[g/a]/tggaccttggggcctggggcctcgggctctggtgaggagctgacacat ttaggatgggga[g/a]agtgataggtctgggaggaattcaggaggcggggcaacaggacttggtgactgagcagat/g/ CD320/CD320 molecule 4765/11/rs2186775/70966737/[g/a]/tcacatacacacattcaaacagaaacaaccccccatacaccctccac acactcctctagt[g/a]tctgggggcttcagactctcacagcttgaagaggagacacgcatctctgctgagcgagcc/g /LOC727727/hypothetical LOC727727 4766/1/rs12060264/235054986/[a/g]/cccccaagcggctatgtaacaagaatgaatgaatttcccttatggg aaggggtggggttg[g/a]gggtattctgttctgcctaacagtgaatattttctttcaaacggaaaagaaataatggag/ a/MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 4767/2/rs7568979/56317890/[a/g]/tcactcagatatagctcattcacttccaccaaagtcagatatcctctt 30 tagattactggc[g/a]tgtcttagagagcagaggtaatctactagtaattcaccaagattatccttattacaatta/g/ CCDC85A/coiled-coil domain containing 85A 4768/7/rs4730037/104129973/[c/t]/atcctgttcttgactcttcggaggatattaatcagaagttcatctgt gtgccaggaaaaa[c/t]acatacgagtgtgttttgttttataattctcttctctgcattattttggattccttcagt/c /LHFPL3/lipoma HMGIC fusion partner-like 3 4769/3/rs782437/128899892/[t/c]/aggggcctggctatctccttcctgggagccacaagccacattcctagg acttttggtgga[c/t]tgagatcttaagctgtcaaaaaatcaaggccattgtgcttgtgccagaactgccacttga/t/ MGLL/monoglyceride lipase 4770/9/rs2281731/3845616/[c/t]/agctgggggatcaggaagggcttcagagaggaggtgtcattccacctgc gccttgaagga[c/t]ggagaggatgtggacctatgagaatgagagcaaaaacctagcagagcagaggcatgcttg/c/G 40 LIS3/GLIS family zinc finger 3 4771/12/rs1596518/39484411/[g/a]/tagtacctgaaataaaattttatggaattattaaataaaatgactag catttgtaaaatg[a/g]caggtggcttgtgaactgtttatgtacacatatcttgtcaacatttgttttgaattttat/g /CNTN1/contactin 1 4772/13/rs916732/31645122/[t/c]/tagattagaatctaacaaacaagtaagcaaggagaaatagaaagtaaa tgtttgaaaatt[c/t]gattcaatagtatccaaaagtctatggagaatttaaataacaactttggccactttgatt/c/ FRY/furry homolog (Drosophila) 4773/19/rs2287671/11469931/[g/t]/cgacctcaaacccgggtctgcgtgtcttgtgtctcaggcgcagtgtc cttggctccctca[t/g]tctcttgctcccggcatgggagtcagccaggggagagccgagcagagggaacagcttttg/t /ZNF653/zinc finger protein 653 50 (332) JP 2010-88432 A 2010.4.22 4774/4/rs11936348/66027549/[t/c]/actaattgttttgtatatttagctcatttgattgttgtaatcattgt atgtcacagatac[c/t]atttatttccactttacatgtgaaaaacctgaggccctgtgatatttacgtaatttactc/c /EPHA5/EPH receptor A5 4775/2/rs10495753/25529199/[t/c]/aagatggatatttgcatgcttaaaattataaagtgttgacaaatgtc ataggcgaagact[c/t]gaagcacttaaaaaaaaatcccagaagaaagactaagttaagcttaaagacttagccaaa/c /DTNB/"dystrobrevin, beta"/ 4776/1/rs4113643/209076544/[g/a]/ccctcatcttccctgtccactttctagcactttccaaaaaaagaggt ctagactacagcc[a/g]tgctaaacagagactatccccatcaggaacatgaaaaccatgtataagtcacagcacttc/a /KCNH1/"potassium voltage-gated channel, subfamily H (eag-related), member 1"/ 4777/19/rs1725474/43276212/[t/c]/aatgctcatatcccatctgctgggagatgcaggtccactcgagactg 10 tctgcttggcggc[c/t]ggggacggccatctggggcaggctggctggcttggaaggcagcccagacctctcgctctg/c /SIPA1L3/signal-induced proliferation-associated 1 like 3/ 4778/9/rs3128625/136913439/[a/g]/gaaactctagaagtatttaaggaagaaaataatgccaccctaacccc accactccacaac[a/g]agccactaggagtttccaagcgaatccccgctgttcctggcctgtgtcacacttcacgcc/g /FCN2/ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 4779/2/rs1963400/226069015/[g/t]/caaggataagcatgttgaaggtatataccagggagtggtagagatga ttgatcacaaaat[g/t]taagctgcatttaggaagacaagatttacagcaattgagaaacacagaaaagattgcaag/g /KIAA1486/KIAA1486 protein/ 4780/3/rs1870258/28365045/[a/g]/gagggagtgagaaaaaaatgacgtgtctttttggaccggcaacagcta cggaggttggcc[a/g]cggcattgcccgcatccctatcctccacccgtccctggcgagtcactcacccagaagcca/g/ 20 AZI2/5-azacytidine induced 2/ 4781/6/rs6921573/167186435/[c/t]/ccaactgatggtgacagcaggaaatgcacctgccctgccccctcgcc cggatactttcta[t/c]tctgctatgaaaaacagagtaaaatttgagaggaaagggaaagtacccccgtagccacaa/t /RPS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2"/ 4782/14/rs7157940/93632946/[t/c]/atttttaatgtttttatagtcccaggagggatgcagagttctttatt aatgcagctttat[t/c]caaaccagatcctgaataaagtcaaaactcaaccaacaggtggaagtccaagaatccgag/c /FAM14B/"family with sequence similarity 14, member B"/ 4783/9/rs4877950/87530274/[t/c]/aggatggtagggggctaatgaacatcagcctctccctctcaaattacc tccacaaacctc[t/c]ccataggcaccgccaactacctgatataagcaaaaaagctctacaagtgtaatggaaaat/c/ AGTPBP1/ATP/GTP binding protein 1 30 4784/1/rs9424977/72497932/[c/t]/tactagtgtattatattccacagcaatgcagtgcatgttctcaatgaa tcaaagctatta[c/t]ggaaagggagcttatacatggagaaaatacatctcattatatccttctaaagggtatcat/t/ NEGR1/neuronal growth regulator 1/ 4785/15/rs2279378/72383547/[c/t]/catctccaccactccgaagctgtgtgaccttggataaatcactccac ctctctgctcctg[c/t]ctcctcattgttaagtagagggaacactgtcaccctgtccacctcttgagactatgggga/c /CCDC33/coiled-coil domain containing 33/ 4786/16/rs8050801/82682771/[g/a]/ccatctgttctcacaaagctgtcaccacctggatgaaaagccaccaa cacactagatatg[a/g]tgcaaagttgggctgcgaaagagcaggagctgtcacccaaaccccgtgtgcagtgactcc/a /MBTPS1/membrane-bound transcription factor peptidase/ 4787/12/rs1426369/107148156/[g/a]/caaaatataaaacataaccatattctataaagtccctgtgtctggg 40 ctcctttttgcagt[g/a]tattccaatgaaaaccattccctgaagcttacttggcttcgacacagatgtcccctggtt/ a/WSCD2/WSC domain containing 2/ 4788/12/rs1426367/107147013/[g/t]/ttgatgaatttgctcattcccagtgccctacccccaggccattact agggcttccatttt[g/t]ccacgtcactcttgcagtttctacacactggggaggtttgacagttatgtggctcatcag/ t/WSCD2/WSC domain containing 2/ 4789/8/rs5003154/82149508/[t/c]/cagatctactgaatcagactctgcattctaataagacccccaggtgat tcacactaaatt[t/c]ggggaaaaacagccttaaaccactgtcacatctgcaccatgctggctcaatttgcaggca/t/ PAG1/phosphoprotein associated with glycosphingolipid microdomains 1/ 4790/4/rs2070022/155724398/[t/c]/tggcagacagaagcttctctctgcaaccttgaagactattggtttga gaacttctcttcc[c/t]ataccacccaaaatcataatgccattggaaagcaaaaagttgttttatccatttgatttg/t 50 (333) JP 2010-88432 A 2010.4.22 /FGA/fibrinogen alpha chain/ 4791/2/rs2540283/102776059/[c/t]/acggtgacctctgacccatgccttctgaagaacagtttgaaagatga attggaatcatcc[c/t]tgtgatcccctaggaactggaaaactgagaaagtgaggtgatgagcagcagagcagaagc/c /TMEM182/transmembrane protein 182 4792/2/rs2732811/102773131/[c/t]/gccctcagcatatgtttgctaaattaagtggcttctggttgtcagca ctgtgcccatttg[c/t]taagcaagcctggcaaggcccctcttagaggcccctgatgagacaccagtttgagttgtt/c /TMEM182/transmembrane protein 182 4793/10/rs1572430/86189487/[g/a]/tgttttgaaaagaaacttttttgagctaaggaacaaaagagtggaga atcctttttggat[a/g]tgagattgttaacttctcttgaggcagaaataaattatatgattgaattatccagacatt/a /KIAA1128/KIAA1128 10 4794/10/rs1904601/49590614/[g/t]/tctgtattattttattaagtcctacatgcctatgaaacatggtttct attacattctgac[g/t]gactaataaaaccctgccagagccagagtgctcagccttcttaattaatagttggtggtg/t /C10orf64/chromosome 10 open reading frame 64 4795/3/rs9853769/98548526/[a/g]/gactccataaatgaatgaaggagagtctgatgataacttgagtcttct agttgggcttac[g/a]tggagcaagaaattggaaggattccatgatgttcaccaacatttttattactgttgaaaa/g/ EPHA6/EPH receptor A6 4796/3/rs9825320/98526743/[a/g]/aataatatagggctttcatgaggaataaataggttaattcattacttt gctagggttgcc[g/a]taatcaagcaccatcgactatgtggctcaaacaacagaaatgtatttcttgcctatttgg/g/ EPHA6/EPH receptor A6 4797/12/rs1674091/112012971/[g/a]/agtcctggccacgtgatactatcctgtatagccgagcagccaccaa 20 gtgggtgtgtgtgc[a/g]ctgcacctgtgtgcatgtgtgattgtgcctctgcatgtgtgcaggtgtgggcctcccagg/ a/DTX1/deltex homolog 1 (Drosophila) 4798/21/rs2186290/35141586/[t/g]/ttctctttaatttcttctcaccaatcctgaaagacacgacgagataa tatctactttcaa[g/t]aaatcaattaattttatttaaaatccctaagattttaatatagtacatgcaaaacaataa/t /RUNX1/runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncog ene) 4799/10/rs9415037/73174430/[t/c]/catgtcagcccctgacattctggttctcactgaagcagggctcagcc cataccagctccc[c/t]ggtgagagcaggagaagctgggtagcatccgccctgctcatcctggtcatcaccagctct/c /CDH23/cadherin-like 23 4800/17/rs8075751/16881961/[g/a]/ccatgggaggccctggaaacctgtagcattcacacattcctccagat 30 gaattttattatc[a/g]atgattagcagaaaaagggcgagatgagagcccagctctcaggtgtggagaactgcttgg/a /LOC100128283/similar to hCG1775427 4801/9/rs3118571/136457999/[g/a]/tccttctcggatgtaagagaaaaataggagaggaacccactttacag taacctttggggt[a/g]tcttcaccttcctaagtgctccatcgctgcaggaaggagggctcctggccctgtgatgtg/a /RXRA/"retinoid X receptor, alpha" 4802/15/rs8028632/73108315/[t/c]/tctccctcctcgtgagacctcatggttgtcttgtcagtcaaatgctc tgaaaccccattg[c/t]ctgaagctctaggttcaaactttgctccttcaggtgttcagagctgccccaggggccccc/c /PPCDC/phosphopantothenoylcysteine decarboxylase 4803/15/rs6494654/65468961/[c/t]/gtgaatggaatgaattctgagtggaatcctattcctagacaagaacc attgggaaattca[c/t]ggaatgataaaggcagcattctagaataaggcagtacaaaagatggcttaaaacgaattt/t 40 /IQCH/IQ motif containing H 4804/5/rs2339745/172292640/[a/g]/tttgctgttgattgacaggggtgtccccaggaccccaacactcaaag tcatggagaagac[a/g]ccaggccttagtgggcagcagagcatggtcagagtctgcagagtgggatgacccagcaat/g /ERGIC1/endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 4805/2/rs1405085/39635071/[g/t]/aggccctgttctgagtaggggaaacagtgatattctaggttcccaggg attagtacaagt[g/t]caaagccatgttcaataatttgtgaaaggtataaatatttttccttctctagtacacagt/t/ LOC728730/hypothetical protein LOC728730 4806/2/rs4670944/39631613/[g/a]/taccacaacttactacagcaagtcaatgggctgataagataaacgctg ttatgtttcaaa[a/g]ttgtgccaagtttatgttgataaagtgactttcttctgggaatctaaaaaacagtgccta/a/ LOC728730/hypothetical protein LOC728730 50 (334) JP 2010-88432 A 2010.4.22 4807/13/rs1327651/49995000/[c/t]/cttcatccctgaagtgcaggccagtcctacctccttcacaatgacgt gctgacatcatgg[c/t]gcaaatttgcaaacattttttgccttattaagaaaattattcaaacctagaaaaatgcaa/t /LOC730194/hypothetical protein LOC730194 4808/7/rs310586/150524562/[g/a]/tgcacccggcactctgaccttcacgcatccatccattctctgcggtca gatacatggaag[g/a]accggtgtgagagcatacaccccagtcagaattatgactccgagaccctccgggaggaga/g/ LOC392843/similar to IQ motif containing with AAA domain 4809/6/rs721101/155674536/[c/t]/ttgaaaccaaccgactcctaagaacagactggataagaatgcagcact tttctatagtta[c/t]tgaacattgaatatctgaataagcaatactagtttcacattcagaatcttcagtattgct/t/ TFB1M/"transcription factor B1, mitochondrial" 4810/5/rs2366981/38414240/[a/g]/ctcacttgcgaacagggataagggaaatctattctgtggctctatgac 10 aacatgtacccc[a/g]ggatcctcgcatgctgtaactggtctccaggcagatgggcaatgaaaaacacagcggccc/g/ EGFLAM/"EGF-like, fibronectin type III and laminin G domains" 4811/1/rs3820571/235127056/[g/t]/tttgaagtccaaatattttgctgtggggaagatttccaaggatcagg taagctagctgtt[g/t]cattatatgtggcttgcctagttcaaatgaaattctagaacctctctcattttaaatgtg/t /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 4812/1/rs2789352/235070620/[t/g]/agtaagtaaaacatactggaatgcaatgcaaccagaaaacatggagt tttaatccactaa[g/t]atgggaaaatgccaacattatgttgagcaggggaaaagagttacagaataccaggtataa/g /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 4813/13/rs3936015/19928892/[g/t]/agtttccctgtgctgggtcacccaggaaggtgcagaaaggccatgaa gagtggggggtgg[t/g]caggtcgtgtaacaggagcatagctggctaggaagagaaggaagagctggggttgctaag/t 20 /CRYL1/"crystallin, lambda 1" 4814/9/rs7030075/569035/[c/a]/atgtctgcagctgaaaataggaaaaattgactatatgcatgtttgaacac atagacataa[a/c]aaatgccagctgaagcagagtattccgcatgcaagccaagaaaaatcgggttcagtgagg/a/KA NK1/KN motif and ankyrin repeat domains 1 4815/5/rs6882998/154124843/[c/t]/taactggtctcctatcactcctacttaaagccctctggtaacttctt agcagagtaaaat[t/c]cagagtccttagagtgttctctaagaccgcacttgatctggtctctgtccacctaacctc/c /LARP1/"La ribonucleoprotein domain family, member 1" 4816/9/rs4978125/20769843/[c/t]/attgtatagctcattcttctgggcattttaattcatgattttgggagt gaattgctcttt[c/t]acctacagtgtgccttggaaatggctttagcacatggaggggatccttggctcctaggct/c/ KIAA1797/KIAA1797 30 4817/22/rs878734/41993678/[g/a]/gagggcagagagggcatgccacccgctctccctctgaggttcggaggc acagaggatacc[a/g]caggtgctccagtgggtggggccagtgccttatccctgccccagcctgccaccctggtcg/a/ SCUBE1/"signal peptide, CUB domain, EGF-like 1" 4818/15/rs2279357/72417676/[t/c]/accaccagctcctggtgtaaccctgcacagtgcctgataatgcaccc ttagtgctgcatt[c/t]ccttgatttaggcctagaccttaacttgtctacaaacctcagtcctatcccatcccatca/c /CYP11A1/"cytochrome P450, family 11, subfamily A, polypeptide 1" 4819/10/rs1870167/88019566/[g/a]/agtgaaatgggaccttgtattacaggcatctttcagggtttccatgg agtacacctaggc[a/g]atggtcaataaatgtgggtcccatatcttagagggcttagagggacagcaaaaagcaaaa/g /GRID1/"glutamate receptor, ionotropic, delta 1" 4820/7/rs2467805/158423340/[a/c]/aggccaaggctgcagtgagccctgattgtgccattgtcctccagcct 40 gggtgacagagtg[a/c]atactgtttctaaaaagaaaaaagaaaggaaatatataatcagaggagaaaaaagaacaa/a /WDR60/WD repeat domain 60 4821/7/rs6965685/158419223/[t/c]/caggtttcttatgagaagcagtctgctgcagatgagctcacaactac aagcatgaagaaa[t/c]agtctaccttggtgcaaaaagtaggagtcacacactaagaacttgagacagttgtacaat/t /WDR60/WD repeat domain 60 4822/11/rs7102217/119692643/[t/c]/ggccctcctgcctcagcctcccaaaagtgttgggctacaggcatga gccaccatgcccag[t/c]tcagttcattactctagtttctagaaaaccaagcaccttttctttgtggagactggagaa/ t/LOC649133/hypothetical protein LOC649133 4823/6/rs9390399/146976076/[a/c]/aaatgatgaacttttaaagttaaaaggccatttaaataatttttgta aaaccaagtgaat[c/a]aaacgtaacacagcatgactttaactattttaatttaaaaaatattttaagattttcaat/a 50 (335) JP 2010-88432 A 2010.4.22 /C6orf103/chromosome 6 open reading frame 103/ 4824/2/rs1052431/102701401/[g/a]/accactagagtgtcgcttgtttagagacattatgaaaatggccacta aggctaacacagc[a/g]cccaggctgggggggccgcaagggctgacctcctgggcaacccccgagaggagaggggcg/g /MFSD9/major facilitator superfamily domain containing 9/ 4825/9/rs4740817/551143/[t/c]/agggtaagccagggaaataaatggactagaaactatgccctaccaggaat agttgaaagg[c/t]tatcggggtggaaaggagagcaaagttaattctcaacttcaggggggcaggattggaatt/c/KA NK1/KN motif and ankyrin repeat domains 1/ 4826/12/rs2243396/112017507/[c/t]/cagatgcttctccaccctgccaccacctgttcatggtctaaatccc tgtactgtccctct[c/t]tgcagggccctgagcaccccaaccccgggaagaagttcaccgcaagaggattccctcgcc/ t/DTX1/deltex homolog 1 (Drosophila)/ 10 4827/19/rs17798650/49040759/[a/c]/atacagtcatcaacaggcaaggcacatgaaaaccccgcacaaccaa gaatgatttgggcc[c/a]aaatgtcagtagatttgagtttggaaaaaccttcttgtagttgttaaggctcaatggctc/ c/ZNF283/zinc finger protein 283/ 4828/19/rs705507/43302561/[g/a]/tagacatcttgtgggttctgtagctaggttcttcctctggaaggtttg tgccagagatct[g/a]tggatcttcatgctattaccttggaaagacaagagatacttattaaccttggacactgat/a/ SIPA1L3/signal-induced proliferation-associated 1 like 3/ 4829/16/rs7186194/82183721/[t/g]/gcagcagaagatgcacacattgcctggaaatgttttatttgattttg gtgtccctcaacc[g/t]caaatctatcatttaggctattccagccacatatgtctaagagacagtgtttatttcccc/g /CDH13/cadherin 13/ 4830/7/rs6968634/131518382/[g/a]/ccaatcaaaggagcatcttcgagaagaatcctgctatctaaaacagg 20 ctttagcaagtta[a/g]ttagctagaagttgatgagtaaagaatccttgacacacacacccacattcatttccaccc/a /PLXNA4/plexin A4/ 4831/6/rs9403527/144089526/[t/c]/aaatccattcattggtcagtggacatttgggctgcatccatctcttg gctattgtggata[c/t]tgctgctctgaacataggtgtgctgtaattagttttatgttaaccattctagtaggtatg/c /PHACTR2/phosphatase and actin regulator 2/ 4832/2/rs6754391/24222523/[t/c]/caccgtttaactctaatagtcatgatgtgtattgtaactacccctgaa aaactagcctga[t/c]gagcatgagaaagatacatgagtgaccttttaagcttgtggtagaatttcactgactagg/c/ LOC375190/hypothetical LOC375190/ 4833/20/rs6033643/13153338/[t/c]/cttagtcagaaatatgcaatggtgagtttatttacctgaattgtagt atgtttgtattca[c/t]ttaaaaagggacacattcttatttaaggatatatcaaggacgcccaataaagtagtagta/c 30 /C20orf82/chromosome 20 open reading frame 82/ 4834/9/rs4135183/112055423/[a/g]/attgctatacttctatgtaccctgctgcagctctccccatgtctcca cctctagaggtgg[a/g]gttcagggatttgcataactaaaaaatttatgaaagtgttgtcctacctttctcaggaac/g /TXN/thioredoxin/ 4835/5/rs12518180/175992222/[c/t]/cacacctctgtaataatttctgagaaaactgttaaagggagttgca cctaggaaacggga[c/t]tgagagggttcagggaaggaagtttcacattccattgccttccttactggtgctgtttga/ c/EIF4E1B/eukaryotic translation initiation factor 4E family member 1B/ 4836/1/rs6703366/55446008/[g/t]/gacttgagcatggtggggtggtatcctggaaccagccccctatggcta tcaagggacaac[t/g]gtatcgtattgcttagtaagtaatggttttataaaatattcttgatataaacttaagtga/t/ USP24/ubiquitin specific peptidase 24/ 40 4837/1/rs557435/55293452/[a/g]/ttatggtatggggggtcctaggcatggagtcttttaattctttagacaa tcctgggagca[g/a]ctgtccctgtttcacagagggcggggccacacagctggtgagtgggcagccaagactctg/g/P CSK9/proprotein convertase subtilisin/kexin type 9 4838/11/rs10899469/77695961/[c/t]/tacaacctctacaacctcatgtgcacctagagtcctagaagtgggt cctttgcattattc[t/c]ctaccaaaggaatcaaaactctctggaaaggggttgattctatgttgtgaagttaaaaaa/ c/GAB2/GRB2-associated binding protein 2/ 4839/20/rs6034006/1467511/[g/t]/cagttgagtcatccccaggtgagtttcccaactgagaccccaggcaac atatagcagaga[t/g]aagtcattcttgtaccctgtctgaattccttacccacagtgtcattgatcataataagat/t/ SIRPD/signal-regulatory protein delta 4840/2/rs10168801/218288795/[g/a]/taaatgttgttttaagtcaataagttttgtagagttttgttatgca 50 (336) JP 2010-88432 A 2010.4.22 gaaaaactaaacca[g/a]tgcagcccataatagccctctacagctatacagaataatctcgtgattccttgtccctga/ g/DIRC3/disrupted in renal carcinoma 3 4841/3/rs9310864/28425375/[c/t]/cagctcagttgttcacatagactgtcaatacctgctttagacttagaa ttatctgaatct[c/t]ttttggtacagggaaagacatctgaaagaaaggaatacagagcccagaaatagattcata/c/ ZCWPW2/"zinc finger, CW type with PWWP domain 2" 4842/5/rs173591/59807480/[c/t]/tagttattaccccttattgattatctactgaatgtcactctatgttagg caccttctata[c/t]gacatttcactcagctttccctgcaacgctatgtgatgcgggtggtaattgtcttttttt/c/P ART1/prostate androgen-regulated transcript 1 4843/6/rs4413610/42176953/[t/c]/tattcatcacccaaagatgccatttgctgagcaactactaagcgctag gcacgtgctgga[c/t]gctttgcctaaatcagtatgtcaccaccacaagaggccttccctgactaccctgttaaag/t/ 10 LOC100128918/hypothetical protein LOC100128918 4844/7/rs1724528/145729032/[c/a]/cttttcgtaacttcttaaatgtgttctggaagactttctggtttgct tgttagtcattac[a/c]atcaaacaataccaagtcactaaaattatgacatagattgggtgagtttgggtttgccac/c /CNTNAP2/contactin associated protein-like 2 4845/7/rs2075464/134163131/[t/c]/tgcccttgttgggttataaaaactaagtgacctggggatatccaatt cagattctgtaga[t/c]ggtcctgagtttgtgttaaatccggtagctttaaacagaagaatgaatgaaaaaagtcat/t /CALD1/caldesmon 1 4846/7/rs2840183/86161394/[t/c]/gagtgagttatttggtcagttgttagagatatttcccattcttatttt caaaactgtatg[t/c]atctaagtgagggaaataattctggtgtcaatccaaacagaattaacctctcacctccac/t/ GRM3/"glutamate receptor, metabotropic 3" 20 4847/11/rs240572/64489314/[t/c]/tcccccctacccccaaacaaggtttagttattcctcctactcccacca aacaaaacaaaa[c/t]taagtttgacacagttctaagggcaaatccattcctgcacaagtggcattttaaaggttg/t/ LOC283129/hypothetical protein LOC283129 4848/15/rs2855523/22762706/[g/a]/aagccctcctgggagggcaggagagttgctgactgaattcagtgaca tgtccagtgattc[a/g]atcttgtcaacataatgaatccccaacaaaaatcatcgacatctggagttctggtgagct/a /SNURF/SNRPN upstream reading frame 4849/15/rs2554430/22745575/[a/g]/ttgcagacatgaggcaacatgtcaggcgtttttatggttctttttat atgttctgttaag[a/g]attggcaaatccaggccaagtgtggtggctcacgcctgtaatcccagcactttgggaggc/g /LOC647795/hypothetical protein LOC647795 4850/1/rs12087284/170778592/[a/g]/aataaagaaaggtgccaagcatagtaaagctctgaaagaaaggagg 30 aaactggaaaggat[g/a]gatggaaagagatttaaggaagtcatttaagtggtcaacaatataaaatgtcttagataa/ g/C1orf9/chromosome 1 open reading frame 9 4851/21/rs2244084/40198919/[g/a]/gctagggcaatgaaaccctgagctgcctaaaggtcagaatccaccat agtgagagatagc[a/g]agtgctgctgtgaataccagaggcacatgggtggtggcgccttcaaggtaaaaactcaaa/a /PCP4/Purkinje cell protein 4 4852/20/rs2249317/1480595/[t/c]/ttaatttccggtttggccctgttcccttgaaccacaagacaggtccat ttggtaaggtat[c/t]gggtacgctgcaactcaagatgattgactccccagttgatacagtctgtgacatctccgt/c/ SIRPD/signal-regulatory protein delta 4853/14/rs6575101/89601545/[a/g]/tcttagtttgggttcccttagaagcagagcttgagccaagaatttga gtgtaagcagttt[g/a]ttgggaggagcaagggatacaggtcggtgcaagggaaagtgaatcgaggaaggaaagtaa/g 40 /KCNK13/"potassium channel, subfamily K, member 13" 4854/9/rs4742236/676753/[a/g]/tgaggggaaatggcagcatcacgtcataagtgcaatgattgttacctatg agcctatccg[a/g]taagggatctgagtgggcccaagcatcacacacgtgctggagctgagtgttctctgagga/g/KA NK1/KN motif and ankyrin repeat domains 1 4855/5/rs252818/106753590/[c/t]/tgatactgtgactattatactctaatccttagaaaaatttgtgaacaa agaatattagca[t/c]acaatgtgatatgtgagtacacaacacagattgcatgccatggattcactcgatcatcac/c/ EFNA5/ephrin-A5 4856/6/rs9368392/22128881/[t/g]/ttcttgtaagtaggtaatatgagtatagttcaaacattttgtttttag gatatcaaaatt[g/t]taggaaccttcattgggtcctttcatagtgatgaatcagaaaaaagatgaaagagtacag/t/ FLJ22536/hypothetical locus LOC401237 50 (337) JP 2010-88432 A 2010.4.22 4857/9/rs1049927/112058576/[g/a]/taaagggagagagcaagcagcgagtcttgaagctctgtttggtgctt tggatccatttcc[a/g]tcggtccttacagccgctcgtcagactccagcagccaagatggtgaagcagatcgagagc/a /TXN/thioredoxin 4858/6/rs9394866/42182084/[g/a]/ctgccgccaagactcttttcaggaacacctgggggagtgtcctttgct ggcaggctcagg[a/g]gagtctccttctcaggcaggcgggggcccttcttgccctccttgctctgaggggccactg/g/ LOC100128918/hypothetical protein LOC100128918 4859/10/rs11258541/13789234/[a/g]/cttcccctctctgctggttaactttcgacagctggcagtttcctta tcaaaacagagacc[g/a]tagtctgtgcctcctccgcctcttgcttgacacacacacacacatacacacacacacgca/ a/FRMD4A/FERM domain containing 4A 4860/6/rs9394865/42181936/[t/c]/gggcttagcctccttctctgctgctgaggagagccgggcctccagctc 10 attccggatctg[c/t]cgcacactgggagttggagagtcttggggaatgtagtccacagagggcagggtcaggctg/t/ LOC100128918/hypothetical protein LOC100128918 4861/8/rs10808814/78063574/[t/c]/ttttaccaagagtaaaccttctttcaaaactggagtcaacagtctca aaccctgccattg[c/t]tttatcaattaagtttatgggatattctaaatcctttgctatcttttcaacaatgtttac/c /PXMP3/peroxisomal membrane protein 3 4862/19/rs324125/57579094/[g/a]/gatgtaaacatgtcgaaaaacctatcaacaattccttagtttcaccac ttcaaaaaattt[a/g]ttctagtgtcaaatcccacattttaaataaatacagaaatgattttgatgattctccatt/g/ LOC400713/zinc finger-like 4863/8/rs4265143/82135843/[t/c]/acattccaaattatatctgttttgcataaattaagtagactttgtaga aaagactggatt[c/t]attatcatgtaaaatacagccattagcagaaaatctagtaactctattcccagacataac/t/ 20 PAG1/phosphoprotein associated with glycosphingolipid microdomains 1 4864/3/rs604300/128925542/[t/c]/agggttggtttctcctgcaggctctccttgccttgtaaatggctgcca tctccctgcatc[t/c]tcacataatcttccctctatgtctgggttctaatcccctctccttacaggacaccagtca/t/ MGLL/monoglyceride lipase 4865/3/rs3344/62389174/[c/t]/agctgtattgctgatctaacgtgctgttccagttccttcttttggctctaa gtgggacta[c/t]tctggatacagtcaggggagaagagggtcctggatgtctaacaagcttttcccatcattg/c/CAD PS/Ca2+-dependent secretion activator 4866/15/rs3784807/71418883/[g/a]/ccaggcagcctggggcaagctttccccagtctgtgggaggcaagctc cctagccccaacc[a/g]agggcatcctccttcacgttccgtgagctacaacaaggtcttcagaatcagctaacataa/g /HCN4/hyperpolarization activated cyclic nucleotide-gated potassium channel 4 30 4867/1/rs2275568/235082251/[g/a]/tcttgttactagacatagaccaaagcttgccgtattacagtattaca aaggcgctgcttc[a/g]taagtagtttttcctactagactccaatctccctaaggagaacacgcgcgtacacacaca/a /MTR/5-methyltetrahydrofolate-homocysteine methyltransferase 4868/6/rs9356791/22126560/[a/g]/aacagaactctatttaatgtcattactgaccatgaaattggcagtttg atattttaggat[g/a]acttttgcttgttagatgtttgtctttggaatgttttgagaactatggcccccgtataag/a/ FLJ22536/hypothetical locus LOC401237 4869/14/rs2287015/75115115/[t/c]/aggagactgtggcgatggtgaatgaaggtcccaaccaggaagagagc gatgacacccctg[c/t]gccggagtccgcactccaagcggaccccagcgtctcggtccatcccagcgtctcggtcca/t /FLVCR2/feline leukemia virus subgroup C cellular receptor family 4870/6/rs3799568/166955825/[c/t]/tccatattagtgaatactgaattggaatttgttcttctttttgctcc 40 tttatatactcat[c/t]ttaaagacattaagcttaattccttatttgtggtcacaatttctgtgatatgccttatgc/t /RPS6KA2/"ribosomal protein S6 kinase, 90kDa, polypeptide 2" 4871/3/rs938391/122817836/[a/g]/tctttcacactcagtagccccagtggggtccagaacaagggttctcat ttattaatgtgc[a/g]taagaatcagatggggagtgtgttaagcatgtaaattccaggagtccatcattccctcag/a/ FBXO40/F-box protein 40 4872/6/rs4441926/77337162/[a/g]/ttcattcagtcaataaatatttatggagagcaaaccaggagaaaaata gttgtagtatga[g/a]gagagagaagtaattagattcaaatgatactcaactagaacttaaagattaataaaatgt/g/ LOC643281/hypothetical LOC643281 4873/6/rs9388724/130041921/[c/t]/gtttttaaaagttgaagtccagtgccttacttacattattctgaata tcaattgtctcta[c/t]agaatactgtaggcataggatccatttgggttttatctctactgaccctaaaaacacact/t 50 (338) JP 2010-88432 A 2010.4.22 /ARHGAP18/Rho GTPase activating protein 18 4874/21/rs8131586/21381641/[g/a]/gttgtgtcctcatctactgtcgctgctcccctcttcagagcacagtc cacacagctcttt[a/g]tcctcctgggttctgataacctgttctcctattggtcctttggactaaggggtcgcaaca/a /NCAM2/neural cell adhesion molecule 2 4875/21/rs8128171/21382821/[g/a]/ttcatatagacgtgcattccagattttgtgtttatgatttctttctt caggataaaatat[a/g]gggggttgttgactttgacattcagggcttggcaaacttagttgagcctttccagtctta/a /NCAM2/neural cell adhesion molecule 2 4876/9/rs3824574/134063698/[a/g]/cacataggtgccgcccagcgccgggcgcagcagccgcatgcgcaggt cggtgagggtgaa[a/g]aactccttgaggcccttggcgctctccagccgcgtgtagaggttgtccatgttgcgcagg/a /NTNG2/netrin G2 10 4877/2/rs1431080/226083329/[t/c]/tcattaatggccctaactattgttcttaatatttctgggggggttct ggattagctacat[c/t]agaaacatctggatatagttttaaaaacacaaattcatcttctacacccacagagattct/t /KIAA1486/KIAA1486 protein 4878/7/rs2788478/158365380/[a/g]/aagaaagacataaagaaaagcgacacaaagaaggttttcattttgat gatgagaggcacc[a/g]aagcaacgtggatagaaaagagaaatcggcaaaagatgagcccaggaaaagggaatccca/g /WDR60/WD repeat domain 60 4879/17/rs758142/53095785/[c/t]/atagtcagaaataacttcccgaaagaggggcgagcggggctggggtgc ctttcccggcta[c/t]acaagcctctgccacaggcacgcaggcatcaaatgtttaccacagacctgggcagaccat/c/ MSI2/musashi homolog 2 (Drosophila) 4880/1/rs7527281/215269714/[a/c]/cacttgactcagaaacaatctattctaggggatattttcccaagcta 20 aatgcactacagg[a/c]ctttcctattcataacattctttagctggtctgcaactcccttaagtgaaaagaaaagga/c /ESRRG/es