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⮫ ᗋ ◊ ✲ 䝉䞁䝍䞊㻌
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㻺㼍㼠㼕㼛㼚㼍㼘㻌㻵㼚㼟㼠㼕㼠㼡㼠㼑㻌㼛㼒㻌㻿㼑㼚㼟㼛㼞㼥㻌㻻㼞㼓㼍㼚㼟㻌
㻺㼍㼠㼕㼛㼚㼍㼘㻌㻴㼛㼟㼜㼕㼠㼍㼘㻌㻻㼞㼓㼍㼚㼕㼦㼍㼠㼕㼛㼚㻌㼀㼛㼗㼥㼛㻌㻹㼑㼐㼕㼏㼍㼘㻌㻯㼑㼚㼠㼑㼞
⮫ᗋ◊✲ࢭࣥࢱ࣮ 2015 ◊✲ᖺሗ ᕳ㢌ゝ
ᖹᡂ 27 ᖺᗘࡢ◊✲ᖺಧࢆⓎ⾜ࡍࡿ࡟࠶ࡓࡗ࡚
ᮾி་⒪ࢭࣥࢱ࣮ 㝔㛗 Ṋ⏣⣧୕
1980 ᖺ㸦᫛࿴ 55 ᖺ㸧࡟ࠊᅜ❧ᮾி➨஧⑓㝔ෆ࡟⮫ᗋ◊✲㒊ࡀタ⨨ࡉࢀࡓࡇ࡜࡟ጞࡲࡗࡓ
⮫ᗋ◊✲㒊㛛ࡣࠊᅜ❧⑓㝔ࡢ⊂❧⾜ᨻἲே໬࡟క࠸ࠊ2003 ᖺ㸦ᖹᡂ 15 ᖺ㸧10 ᭶ 1 ᪥࡟ᮾ
ி་⒪ࢭࣥࢱ࣮ ⮫ᗋ◊✲㸦ឤぬჾࢭࣥࢱ࣮㸧ࢭࣥࢱ࣮࡜ࡋ࡚Ⓨ㊊ࡋࡓࠋⓎ㊊௨᮶ࠊ㡰ㄪ࡟
ᡂᯝࢆୖࡆ࡚ࡁ࡚࠸ࡿࠋ
ᅜ࡛ࡣࠊ2015 ᖺ 4 ᭶࡟᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ(AMED)ࢆタ❧ࡋࠊᇶ♏◊✲࠿ࡽᐇ⏝໬࡬
୍㈏ࡋ࡚⧅ࡄࣉࣟࢪ࢙ࢡࢺࡢᐇ᪋ࠊඹ㏻ᇶ┙ࡢᩚഛ㺃฼ά⏝ࢆ┠ᣦࡋ࡚ࠊᩥ㒊⛉Ꮫ┬ࠊཌ⏕
ປാ┬ࠊ⤒῭⏘ᴗ┬ࡢ◊✲㈨㔠ࢆࠊ⥲ྜㄪᩚࢆ⾜ࡗ࡚⥲ྜⓗ࡞ㄪᩚ㓄ศࡀ㛤ጞࡉࢀ࡚࠸ࡿࠋ
ࡉࡽ࡟ࠊ་⒪ἲ࡟ᇶ࡙ࡃ⮫ᗋ◊✲୰᰾⑓㝔ࡢᣦᐃࡀ㛤ጞࡉࢀ࡚࠾ࡾࠊᮏ㑥࡟࠾ࡅࡿ⮫ᗋ◊✲
ࡢ᪂ࡋ࠸௙⤌ࡳࡀฟ᮶ୖࡀࡾࡘࡘ࠶ࡿࠋ
ᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮࡜ࡋ࡚ࡶࠊࡇࢀࡽࡢᅜෆ≧ἣࡢኚ໬࡟༑ศ࡟ᑐᛂ࡛ࡁ
ࡿయไసࡾ࡜ᐇ⦼ࢆୖࡆ࡚࠸ࡃᚲせࡀ࠶ࡿࠋ᫖ᖺᮎ࡟ࡣ ISO 15189 ࢆཷᑂࡋࠊ⌧ᅾ⤖ᯝᚅ
ࡕ࡛࠶ࡿࡀࠊ⮫ᗋ᳨ᰝ㒊㛛ࡀ᳨య᳨ᰝࠊ⏕య᳨ᰝࢆྵࡵ࡚ᅜ㝿ㄆドࢆᚓࡿࡇ࡜࡟࡞ࡾࠊᑗ᮶
ண᝿ࡉࢀࡿᅜ㝿ඹྠ἞㦂ࡢ᪋タᇶ‽࡬ࡢᑐ⟇ࢆ㐍ࡵ࡚࠸ࡿࠋࡲࡓࠊᩥ㒊⛉Ꮫ┬࡜ཌ⏕ປാ┬
࡟ࡼࡾᖹᡂ 26 ᖺ 12 ᭶࡟ไᐃ࣭࿌♧ࡉࢀࡓࠊ
ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖ
࡟ᇶ࡙ࡁࠊ㝔ෆࡢ೔⌮ጤဨ఍つ⛬ࡢᨵಟࢆ⾜ࡗ࡚ࡁࡓࠋ
୍᪉࡛ࠊ㝔ෆࡢ⮫ᗋ◊✲ࡢ࢖ࣥࣇࣛࢆᩚഛࡍࡿࡓࡵ࡟ࠊ⮫ᗋ◊✲ᨭ᥼㒊㛛ࡢタ⨨ࡢ᳨ウࢆ
ጞࡵ࡚࠸ࡿࠋࢫ࣮࣌ࢫࠊ࣐ࣥࣃ࣮࣡࡜ࡶ࡟୙㊊ࡋ࡚࠸ࡿ୰࡛ࡢ❧ୖࡆࡔࡅ࡟ࠊ㞴⏘ࡀண᝿ࡉ
ࢀࡿࡀࠊ᪂ࡋ࠸᫬௦ࡢ⮫ᗋ◊✲࡟⪏࠼࠺ࡿࡼ࠺࡞యไసࡾࢆᐇ⌧ࡋࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ
ẖᖺ㛤ദࡋ࡚࠸ࡿឤぬჾࢩ࣏ࣥࢪ࣒࢘ࡣࠊᮏᖺࡣ 3 ᭶ 4 ᪥࡟㛤ദணᐃ࡛ࠊ➨ 11 ᅇࢆ㏄࠼
ࡿࠋࢸ࣮࣐ࡣࠗ㧗㱋⪅࡜་⒪ ࢧࢡࢭࢫࣇ࣭࢚ࣝ࢖ࢪࣥࢢ࡬ࡢᣮᡓ࡛࠘ࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮
ࡢࡍ࡭࡚ࡢ㒊㛛ࡼࡾⓎ⾲ࢆ࠾㢪࠸ࡋ࡚࠸ࡿࠋ͆㧗㱋⪅་⒪͇࡜࠸࠺ࡍ࡭࡚ࡢ㒊㛛࡟ඹ㏻ࡍࡿ
࣮࣮࢟࣡ࢻࡀ࠶ࡗࡓࡇ࡜ࠊࡑࡢ࣮࣮࢟࣡ࢻࡀ⌧ᅾࡢ᪥ᮏࡢ་⒪ࡢᢪ࠼࡚࠸ࡿၥ㢟࡜୍⮴ࡋ
࡚࠸ࡓࡇ࡜ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮ࡢ┠ᣦࡋ࡚࠸ࡿ᪉ྥᛶࡀࠊṇࡋ࠸᪉ྥࢆྥ࠸࡚ࡁ࡚࠸ࡓࡇ
࡜ࢆ≀ㄒࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋ௒ᚋࡢⓎᒎࢆᮇᚅࡋ࡚࠸ࡿ࡜ࡇࢁ࡛࠶ࡿࠋ
㛗ᖺࠊᮏ㝔࡟㈉⊩࠸ࡓࡔ࠸ࡓ⫈ぬ࣭ᖹ⾮ぬ◊✲㒊㛗ࡢ⸨஭ṇேඛ⏕ࡀࠊᖹᡂ 28 ᖺ 3 ᭶ᮎ
ࢆࡶࡗ࡚ᐃᖺ㏥⫋ࡉࢀࡲࡍࠋ㛗ᖺࡢࡈຌ⦼࡟ᩗពࢆ⾲ࡍࡿ࡜࡜ࡶ࡟ࠊឤㅰ⏦ࡋୖࡆࡲࡍࠋ
ᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮
ᖹᡂ 27 ᖺ ◊✲ሗ࿌ ┠ḟ
ᕳ㢌ゝ Ṋ⏣⣧୕ ᮾி་⒪ࢭࣥࢱ࣮⑓㝔㛗
Ϩ㸬ྛ◊✲㒊ࡢ◊✲ሗ࿌
i㸯 ᨻ⟇་⒪௻⏬◊✲㒊
‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 1
ࠝ⮫ᗋ␿Ꮫ◊✲ᐊࠞ
Mechanical prophylaxis is a heparin-independent risk for anti-platelet factor 4/heparin antibody
formation after orthopedic surgery. ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 2
Bito S, Miyata S, Migita K, Nakamura M, Shinohara K, Sato T,
Tonai T, Shimizu M, Shibata Y, Kishi K, Kubota C, Nakahara S,
Mori T, Ikeda K, Ota S, Minamizaki T, Yamada S, Shiota N,
KameiM, Motokawa S.
ᕷ୰⑓㝔࡟࠾ࡅࡿ⮫ᗋ◊✲άືࡢᨭ᥼ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 3
ᑿ⸨ ㄔྖ
ᶆ‽ホ౯㡯┠ࢆ⏝࠸ࡓᆅᇦデ⒪ᡤࡢໟᣓⓗホ౯◊✲
‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 5
ᯇᮧ┿ྖࠊᑿ⸨ㄔྖ
⬤ᙅ㧗㱋⪅ࡢデ⒪᝟ሗᥦ౪᭩ࣇ࢛࣮࣐ࢵࢺ㛤Ⓨ࡟㛵ࡍࡿ ࢖ࣥࢱࣅ࣮ࣗㄪᰝ ‥‥‥‥‥‥‥‥‥‥‥ 11
ᯇᮧ┿ྖࠊᑿ⸨ㄔྖࠊ᪂᳃ຍዉᏊ
ࠝ་⒪⤒Ⴀ᝟ሗ࣭㧗㱋⪅ࢣ࢔◊✲ᐊࠞ
㧗㱋⪅ࢣ࢔◊✲ᐊ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 14
་⒪⤒Ⴀ᝟ሗ◊✲ᐊ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 15
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍࣭Ꮫ⾡ㅮ₇఍ 2015.5.23 ༓௦⏣༊ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 19
ຍᡃྩᏕࠊ༡ಟྖ㑻ࠊ᪂ṇ⏤⣖Ꮚ
ࠝᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺᢏ⾡ᛂ⏝◊✲ᐊࠞ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 21
ࠝ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊࠞ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 23
Corrective and Preventative Actions (CAPA)࡟ࡼࡿ㐓⬺㜵Ṇ࡬ࡢྲྀࡾ⤌ࡳ ‥‥‥‥‥‥‥‥‥‥‥‥ 25
✄ྜྷ⨾⏤⣖ࠊᮏஂ⨾Ꮚࠊᔱᒸ ⥳ࠊ⸨ᕝ཭Ꮚࠊ㧘ᮌᜨ⨾ࠊ➉ୗᬛᜨࠊ▼஭཭㔛ࠊ㔠ග❶Ụࠊ
୰ᕝ⏤⨾ࠊ㏆⸨┤ᶞ
First-in-human ➨Ϩ┦་ᖌ୺ᑟ἞㦂ࡢᐇ᪋ࢆ㏻ࡋ࡚ࡢホ౯࡜⪃ᐹ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 27
㧘ᮌ ᜨ⨾ࠊ⸨ᕝ ཭Ꮚࠊ➉ୗ ᬛᜨࠊඵ௦ ᬛᏊࠊ✄ྜྷ⨾⏤⣖ࠊ㔠ග ❶Ụࠊ୰ᕝ ⏤⨾ࠊ
ᮏஂ⨾Ꮚࠊᔱᒸ ⥳ࠊ▼஭ ཭㔛ࠊ㏆⸨ ┤ᶞࠊ຾ᾏ Ꮫࠊ
༓⏣ ᫀஅࠊஂಖ⏣⠜ྖࠊ㇂ᆅ ㇏ࠊ㕥ᮌ ⩏ᙪࠊᵻᒣ ᖾᙪ
Portfolio ᐇ⏝∧ࡢసᡂ ̿ᶆ‽໬࣒࢝ࣜ࢟ࣗࣛ࡟ᇶ࡙࠸ࡓホ౯ࢶ࣮ࣝࢆ᳨ウ̿ ‥‥‥‥‥‥‥‥‥ 29
✄ྜྷ ⨾⏤⣖ࠊᚋ⸨ ⨾✑ࠊ῝ᕝᜨ⨾Ꮚ
i㸰 どぬ◊✲㒊
どぬ◊✲㒊
ࠝどぬ⏕⌮Ꮫ◊✲ᐊࠞ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 31
㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ⑕౛Ⓩ㘓ࢿࢵࢺ࣮࣡ࢡ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 32
ゅ⏣࿴⦾
࣮ࠝࣟࣅࢪࣙࣥ◊✲ᐊࠞ
᪂ࡓ࡞㧗⢭ᗘ║ෆࣞࣥࢬᗘᩘィ⟬⌮ㄽᘧࡢ㛤Ⓨ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 37
㔝⏣ᚭࠊ኱἟୍ᙪ
i㸱 ⫈ぬ࣭ᖹ⾮ぬ◊✲㒊
⫈ぬ࣭ᖹ⾮ぬ◊✲㒊 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 43
࣮࣡ࣝࢹࣥࣈࣝࢢ⑕ೃ⩌Ϩᆺࡢ᪂ࡓ࡞㑇ఏⓗཎᅉࡢ᳨ウ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 45
ᯇỌ㐩㞝ࠊົྎⱥᶞࠊ㞴Ἴ୍ᚨ
Exome ゎᯒࢆ⏝࠸ࡓ⑕ೃ⩌ᛶ㞴⫈࡟ᑐࡍࡿཎᅉ㑇ఏᏊྠᐃࡢヨࡳ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 47
ົྎⱥᶞ࣭௰㔝ᩔᏊ࣭᭷ᮏ཭ᏘᏊ࣭ᯇỌ㐩㞝
㞴⫈㑇ఏᏊ LOXHD1 ࡢ᪂つኚ␗యࡢศᏊ⑓ែࡢ᳨ド ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 50
㞴Ἴ୍ᚨ
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤Ⓨ࡟㛵ࡍࡿ◊✲ ‥‥‥‥‥‥‥ 52
༡ಟྖ㑻
ෆ⪥እഃቨ⥺⥔⣽⬊ࡢ෌⏕࡜⼗∵ෆ㟁఩ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 55
Ỉ㊊㑥㞝
㞴἞ᛶᮎᲈᛶࡵࡲ࠸ࡢ㔜⑕ᗘ࡟ᙳ㡪ࡍࡿᚰ⌮♫఍ⓗせᅉࡢ᳨ウ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 57
஬ᓥྐ⾜ࠊⲨ஭⨾ᕼࠊ∦ᒸᯞ㔛Ꮚࠊఀ㐩ዉ⨾ࠊ୕ᾆṇ⛱
㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿࣄࢺங㢌⭘࢘࢖ࣝࢫ㸦HPV㸧ࡢ㛵୚ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 60
ᚨ୸ ⿱ࠊ⸨஭ṇே
㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿࡀࢇᖿ⣽⬊ᵝ⣽⬊࣐࣮࣮࢝ࡢⓎ⌧࡜ࡑࡢ⮫ᗋⓗព⩏࡟㛵ࡍࡿ᳨ウ
-StageϨ/ϩ⯉ᡥᖹୖ⓶⒴࡟࠾ࡅࡿᚋⓎ㢕㒊ࣜࣥࣃ⠇㌿⛣࡟࠾࠸࡚- ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 63
⩚⏕᪼ ⸨஭ṇே
ࢹࢢ࢚ࣜࣥࡣ㢌㢕㒊ᡥᖹୖ⓶⒴⣽⬊ᰴ࡟࠾࠸࡚ EGFR ࢖ࣥࣄࣅࢱ࣮ࡢᢠ⭘⒆ຠᯝࢆቑ኱ࡉࡏࡿ ‥‥‥ 66
㤿ሙඃ ⸨஭ṇே
⮬ᐙ㦵⨨᥮ᆺ྾཰ᛶேᕤ㦵ࡢຠ⋡ⓗ࡞㦵෌⏕࡟ࡴࡅ࡚ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 68
ⴠྜ༤Ꮚࠊᆏᮏዲ᫛
i㸲 ேᕤ⮚ჾ㺃ᶵჾ㛤Ⓨ◊✲㒊
ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 75
Patients' perceptions of vocal problems: results from a survey in the Tokyo area. ‥‥‥‥‥‥‥‥ 77
Tsunoda K, Fujimaki Y, Nito T, Yamasoba T, Tayama N, Makiyama K,
Murofushi T, Tsunoda A, Ohshima K, Nishiyama K, Kano S, Niimi S.
Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory
neurons after injury in adult mice. ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 78
Kikuta S, Sakamoto T, Nagayama S, Kanaya K, Kinoshita M, Kondo K, Tsunoda K,
Mori K, Yamasoba T.
Prtformance Eveluation of Ad Hoc Network Protocol Implemented in Server Side Java Script ‥‥ 79
Atsushi Ito, Hiroyuki Hatano, Masahiro Fujii, Mie Sato, Yu Watanabe
Yuko Hiramatsu, Fumihiro Sato, Akira Sasaki
Bluetooth Low Energy ࢆ⏝࠸ࡓ࢔ࢻ࣍ࢵࢡࢿࢵࢺ࣮࣡ࢡࡢᵓ⠏ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 85
ຍ⸨ᣅஓࠊఀ⸨⠜ࠊ⸨஭㞞ᘯࠊ⩚ከ㔝⿱அࠊΏ㎶⿱ࠊᏱ㒔ᐑᰤ஧
i㸳 ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊
ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 87
ⁱฟᆺຍ㱋㯤ᩬኚᛶឤཷᛶ㑇ఏᏊ ARMS2-HTRA1 ࡢゎᯒ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 89
ᐙᓥ኱㍜㸪୰ᒣ┿ኸ㸪㔝⏣ᚭ㸪ᒾ⏣ᓅ
㑇ఏᛶ⥙⭷Ⰽ⣲ኚᛶᝈ⪅࡜㗹యᮞయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅ࡑࢀࡒࢀ࠿ࡽぢࡘ࠿ࡗࡓ &RUI 㑇ఏᏊࡢ᪂
つኚ␗ࡢྠᐃ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 95
ᒸᮏᬗᏊࠊ⁁⏣῟ࠊຍ⸨ගᘯࠊᅧྜྷ୍ᶞࠊྜྷṊ࿴ᩄࠊWilliam C.Sultanࠊᒣᓮṇᚿࠊゅ⏣࿴⦾ࠊ
ᒾ⏣ᓅ
21 ᆺ཮ᴟ⣽⬊␗ᖖࢆక࠺㯤ᩬኚᛶᐙ⣔ࡢཎᅉ㑇ఏᏊゎᯒ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 98
ᕝᮧ㞝୍ࠊ⸨ᕳᣅ㑻ࠊྜྷṊ࿴ᩄࠊゅ⏣࿴⦾ࠊᮧୖ ᬗࠊᒾ⏣ ᓅ
ϩ㸬ᴗ⦼㞟㸦Ꮫ఍Ⓨ⾲ࠊㄽᩥࠊ୺ദࢩ࣏ࣥࢪ࣒࢘㸧
Ϫ㸬◊✲㈝
ϫ㸬⤌⧊⾲
Ϭ㸬⥘㡿࣭つ⛬࡞࡝
࣭⮫ᗋ◊✲ࢭࣥࢱ࣮タ⨨㐠Ⴀ⥘㡿 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 235
࣭⛉Ꮫ◊✲㈝⿵ຓ㔠࡟ࡼࡿ◊✲ᐇ᪋つ⛬ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 238
࣭㑇ఏᏊ⤌᥮࠼ᐇ㦂⟶⌮つ⛬ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 239
࣭ື≀ᐇ㦂⟶⌮つ⛬ ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 242
࣭ື≀ᐇ㦂ᣦ㔪 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 251
㻌
ϭ㸬⮫ᗋ◊✲ࢭࣥࢱ࣮ධ㒊࣭㏥㒊௚ᡭ⥆᭩㢮
࣭ධ㒊࣭㏥㒊㛵ಀ᭩㢮 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 255
࣭ࢭࣥࢱ࣮ㅮᖌᐟἩ᪋タ฼⏝ᡭ㡰 㻌‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥ 263
⦅㞟ᚋグ ຍᡃྩᏕ ྡ㄃⮫ᗋ◊✲ࢭࣥࢱ࣮㛗
⮫ᗋ◊✲䝉䞁䝍䞊㛗
஦ົྲྀᢅ䚷㻔Ṋ⏣㻌⣧୕㻕
ྡ㄃⮫ᗋ◊✲䝉䞁䝍䞊㛗
㻔Ᏹ἞䚷ᖾ㶾㻕
ྡ㄃⮫ᗋ◊✲䝉䞁䝍䞊㛗
㻔ຍᡃ㻌ྩᏕ㻕
⮫ᗋ◊✲䝉䞁䝍䞊⤌⧊ᅗ
ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊
㻔ᒾ⏣㻌ᓅ㻕
ேᕤ⮚ჾ䞉ᶵჾ㛤Ⓨ◊✲㒊
㻔ゅ⏣㻌᫭୍㻕
⫈ぬ䞉ᖹ⾮ぬ◊✲㒊
㻔⸨஭㻌ṇே㻕
どぬ◊✲㒊
㻔ゅ⏣䚷࿴⦾䠅
ᨻ⟇་⒪௻⏬◊✲㒊
㻔䝉䞁䝍䞊㛗ే௵㻌㻕
㻌⚄⤒⏕≀Ꮫ◊✲ᐊ䚷㻔ᒾ⏣㻌ᓅ㻕
㻌どぬ⏕≀Ꮫ◊✲ᐊ䚷㻔ᒾ⏣㻌ᓅ㻕
㻌Ⓨ⏕་Ꮫ◊✲ᐊ䚷㻔ゅ⏣㻌᫭୍㻕
㻌㡢ኌ䞉ゝㄒ䝁䝭䝳䝙䜿䞊䝅䝵䞁◊✲ᐊ䚷㻔ゅ⏣㻌᫭୍㻕
㻌௦⏝⮚ჾ㛤Ⓨ◊✲ᐊ䚷㻔ゅ⏣㻌᫭୍㻕
㻌෌⏕་⒪◊✲ᐊ䚷㻔ⴠྜ㻌༤Ꮚ㻕
㻌ᖹ⾮ぬ㞀ᐖ◊✲ᐊ䚷㻔஬ᓥ㻌ྐ⾜㻕
㻌⫈ぬ㞀ᐖ◊✲ᐊ䚷㻔ᯇỌ㻌㐩㞝㻕
║⛉␿Ꮫ◊✲ᐊ
㻌䝻䞊䝡䝆䝵䞁◊✲ᐊ䚷㻔㔝⏣㻌ᚭ㻕
㻌どぬ⏕⌮Ꮫ◊✲ᐊ䚷㻔ゅ⏣㻌࿴⦾㻕
⮫ᗋ◊✲䞉἞㦂᥎㐍ᐊ䚷㻔ᵻᒣ㻌ᖾᙪ㻕
㻌ᡭ⾡ᨭ᥼䝻䝪䝑䝖ᢏ⾡ᛂ⏝◊✲ᐊ䚷㻔ᩧ⸨㻌ྐ㑻㻕
㻌་⒪⤒Ⴀ᝟ሗ䞉㧗㱋⪅䜿䜰◊✲ᐊ䚷㻔ᮏ⏣㻌⨾࿴Ꮚ㻕
㻌⮫ᗋ␿Ꮫ◊✲ᐊ䚷㻔ᑿ⸨㻌ㄔྖ㻕
㻌
㻌
㻌
㻌
䊠㻌 ྛ◊✲㒊䛾◊✲ሗ࿌㻌
㻌
㻌
㻌
㻌
㻌
ᨻ⟇་⒪௻⏬◊✲㒊㻌
㻌
㒊㛗㻌 㻌 㻌 䝉䞁䝍䞊㛗ే௵㻌
㻌
⮫ᗋ␿Ꮫ◊✲ᐊ㻌 㻌 㻌 㻌 㻌
㻌 㻌 㻌 㻌 㻌 㻌 ᑿ⸨㻌 ㄔྖ㻌 ᐊ㛗㻌
་⒪⤒Ⴀ᝟ሗ䞉㧗㱋⪅䜿䜰◊✲ᐊ㻌 㻌 㻌 ᮏ⏣㻌 ⨾࿴Ꮚ㻌 ᐊ㛗㻌
ᡭ⾡ᨭ᥼䝻䝪䝑䝖ᢏ⾡ᛂ⏝◊✲ᐊ㻌 㻌 㻌 㻌 ᩧ⸨㻌 ྐ㑻㻌 ᐊ㛗㻌
⮫ᗋ◊✲䞉἞㦂᥎㐍ᐊ㻌
㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᵻᒣ㻌 ᖾᙪ㻌 ᐊ㛗㻌
ᨻ⟇་⒪௻⏬◊✲㒊 ⮫ᗋ␿Ꮫ◊✲ᐊ㛗 ᑿ⸨ ㄔྖ
⮫ᗋ␿Ꮫ◊✲ᐊ
⮫ᗋ␿Ꮫ◊✲ᐊ࡛ࡣࠊᩥ㒊⛉Ꮫ◊✲㈝ࡸᅜ❧⑓㝔ᶵᵓ㐠Ⴀ㈝஺௜㔠◊✲㈝࡛⾜ࢃࢀࡿከ᪋
タඹྠ⮫ᗋ◊✲➼ࠊࡉࡲࡊࡲ࡞⮫ᗋ◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
࣭ 㹌㹆㹍ከ᪋タඹྠ◊✲㸦㹃㹀㹋᥎㐍◊✲஦ᴗ㸧࡜ࡋ࡚ᐇ᪋ࡉࢀࡓࠊ
ࠕேᕤᰤ㣴㸦୰ᚰ㟼⬦
ᰤ㣴ࡶࡋࡃࡣ⤒⭠ᰤ㣴㸧ࢆ⾜࠺㝿ࡢ་⒪⾜ⅭࡢᏳ඲ᛶࠊᝈ⪅ணᚋ࡟㛵ࡍࡿほᐹ◊✲ࠖ
㸦JAPOAN ◊✲㸧⤖ᯝࡀࠊேᕤᰤ㣴࡟㛵ࡍࡿⱥᩥㄅ࡛᭷ྡ࡞ Journal of Parenteral and
Enteral Nutrition (JPEN)࡟ཎⴭㄽᩥ࡜ࡋ࡚ᥖ㍕ࡉࢀࡲࡋࡓࠋBito S et. Al. Prospective
cohort study comparing the effects of different artificial nutrition methods on longterm survival in the elderly: Japan Assessment Study on Procedures and Outcomes
of Artificial Nutrition (JAPOAN). JPEN J Parenter Enteral Nutr. 2015
May;39(4):456-64.
࣭ 㹌㹆㹍ከ᪋タඹྠ◊✲㸦㹃㹀㹋᥎㐍◊✲஦ᴗ㸧࡜ࡋ࡚ᐇ᪋ࡉࢀࡓࠊࠕேᕤ㛵⠇⨨᥮⾡ᚋ
ࡢ㟼⬦⾑ᰦሰᰦ⑕ࡢᐇែ࡜ண㜵࡟㛵ࡍࡿ⮫ᗋ◊✲ࠖ㸦J-PSVT ◊✲㸧ࡢ⤖ᯝࡀࠊBlood
ㄅ࡟ཎⴭㄽᩥ࡜ࡋ࡚ᥖ㍕ࡉࢀࡲࡋࡓࠋBito S et al. Mechanical prophylaxis is a
heparin-independent risk for anti-platelet factor 4/heparin antibody formation after
orthopedic surgery. Blood. 2016 Feb 25;127(8):1036-43.
࣭ ཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠஦ᴗ ࠕ◊✲࣐࢖ࣥࢻࢆᣢࡘ⮫ᗋ་࡟ᑐࡍࡿ␿Ꮫᩍ⫱ࣉࣟ
ࢢ࣒ࣛࡢ㛤Ⓨ࡜ᇶ┙ᩚഛ㸦୺௵◊✲⪅ 㧗ᶫ ⌮㸧ࠖ㸸ᕷ୰⑓㝔࡟໅ົࡍࡿⱝ࠸་ᖌࡀ
⮫ᗋ◊✲ࡢᢏ⾡ࢆᏛࡧࠊᐇ㝿࡟ᐇ᪋ࡍࡿࡇ࡜ࢆᨭ᥼ࡍࡿࡓࡵࡢ◊✲஦ᴗ࡛ࡍࠋ
࣭ ⛉◊㈝஦ᴗ ࠕ࡜ࡶ࡟⪃࠼ࡿ࢖ࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺࠖᐇ㊶ࣔࢹࣝࡢᥦ♧࡜᭷ຠ
ᛶࡢ᳨ド (୺௵◊✲⪅ ᑿ⸨ㄔྖ)㸸ᝈ⪅ࡉࢇ࡟࡜ࡗ࡚᭱ၿ࡜࡞ࡿデ⒪㑅ᢥࣉࣟࢭࢫࢆ
᳨ドࡋࠊࡑࡢ᭷ຠᛶࢆほᐹࡍࡿࡓࡵࡢ◊✲஦ᴗ࡛ࡍࠋ3ᖺィ⏬ࡢ࠺ࡕࡢ஧ᖺࡢ◊✲ᮇ㛫
ࡀ⤊஢ࡋࡲࡋࡓࠋ
࣭ ⛉◊㈝஦ᴗ ࠕ⬤ᙅ㧗㱋⪅ࡢࢣ࢔⛣⾜᫬࡟࠾ࡅࡿデ⒪᝟ሗఏ㐩ࡢࡓࡵࡢᶆ‽ⓗࣇ࢛࣮
࣐ࢵࢺ㛤Ⓨࠖ
㸦୺௵◊✲⪅ ᯇᮧ┿ྖ㸧㸸ᝈ⪅ࡉࢇࡀධ㝔ࠊ࠶ࡿ࠸ࡣ㏥㝔ࡍࡿ㝿࡟ࠊ⑓
㝔࡜デ⒪ᡤࡢᝈ⪅ࡉࢇ࡟㛵ࡍࡿ᝟ሗᥦ౪ࡢෆᐜࢆྫྷ࿡ࡋࠊࡼࡾ඘ᐇࡋࡓෆᐜࢆ⏦ࡋ㏦
ࡿࣇ࢛࣮࣐ࢵࢺࢆ㛤Ⓨࡍࡿࡓࡵࡢ◊✲࡛ࡍࠋ3ᖺィ⏬ࡢ࠺ࡕ୍ᖺࡢ◊✲ᮇ㛫ࡀ⤊஢ࡋࡲ
ࡋࡓࠋ
࣭ ཌ⏕ປാ┬ࣔࢹࣝ஦ᴗ ࠕᖹᡂ27ᖺᗘ ே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ་⒪యไᩚഛ஦ᴗࠖ
᪥ᮏ඲ᅜ࠿ࡽ5ࡘࡢࣔࢹࣝ஦ᴗయ᪋タࡀ㑅ᐃࡉࢀࠊᮾி་⒪ࢭࣥࢱ࣮ࡀࡑࡢ୍ࡘ࡟㑅ࡤ
ࢀ஦ᴗࢆ⾜࠸ࡲࡋࡓࠋᙜ㝔࡛ࡣࠕ㝔ෆ೔⌮ࢥࣥࢧࣝࢸ࣮ࢩࣙࣥ஦ᴗࠖࢆ୰ᚰ࡟ࠊពᛮ
Ỵᐃ࡟ᑐࡋ࡚೔⌮ⓗ࡞᳨ウࡀᚲせ࡟࡞ࡿ஦౛࡟ᑐࡋ࡚ࠊࢳ࣮࣒࡛ពᛮỴᐃᨭ᥼ࢆ⾜࠺
஦ᴗ࡛ࡍࠋάⓎ࡞άືࢆᖺ㛫ࢆ㏻ࡋ࡚⾜࠺ࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ
―1―
[⮫ᗋ␿Ꮫ◊✲ᐊ]
Mechanical prophylaxis is a heparin-independent risk for anti-platelet factor 4/heparin
antibody formation after orthopedic surgery.
Published in Blood. 2016 Feb 25;127(8):1036-43. doi: 10.1182/blood-2015-06-651620.
Epub 2015 Dec 9.
Bito S(1), Miyata S(2), Migita K(3), Nakamura M(4), Shinohara K(3), Sato T(3),
Tonai T(3), Shimizu M(3), Shibata Y(3), Kishi K(3), Kubota C(3), Nakahara S(3),
Mori T(3), Ikeda K(3), Ota S(3), Minamizaki T(3), Yamada S(3), Shiota N(3), Kamei
M(5), Motokawa S(6).
Platelet-activating antibodies, which recognize platelet factor 4 (PF4)/heparin complexes,
induce
spontaneous
heparin-induced
thrombocytopenia
(HIT)
syndrome
or
fondaparinux-associated HIT without exposure to unfractionated heparin (UFH) or lowmolecular-weight heparin (LMWH). This condition mostly occurs after major orthopedic
surgery, implying that surgery itself could trigger this immune response, although the
mechanism is unclear. To investigate how surgery may do so, we performed a multicenter,
prospective study of 2069 patients who underwent
total knee arthroplasty (TKA) or hip
arthroplasty.
patients
Approximately
half
of
the
received
postoperative
thromboprophylaxis with UFH, LMWH, or fondaparinux. The other half received only
mechanical thromboprophylaxis, including dynamic (intermittent plantar or pneumatic
compression device), static
(graduated compression stockings [GCSs]), or both. We
measured anti-PF4/heparin immunoglobulins G, A, and M before and 10 days after
surgery using an immunoassay. Multivariate analysis revealed that dynamic mechanical
thromboprophylaxis (DMT) was an independent risk factor for seroconversion (odds
ratio [OR], 2.01; 95% confidence interval [CI], 1.34-3.02; P = .001), which was confirmed
with propensity-score matching (OR, 1.99; 95% CI, 1.17-3.37; P = .018). For TKA, the
seroconversion rates in patients treated with DMT but no anticoagulation and in
patients treated with UFH or LMWH without DMT were similar, but significantly higher
than in patients treated with only GCSs. The proportion of patients with •1.4 optical
density units appeared to be higher among those treated with any anticoagulant plus
DMT than among those not treated
with DMT. Our study suggests that DMT increases
risk of an anti-PF4/heparin immune response, even without heparin exposure. This trial
was registered to www.umin.ac.jp/ctr as #UMIN000001366.
© 2016 by The American Society of Hematology.
―2―
ࠝ⮫ᗋ␿Ꮫ◊✲ᐊࠞ
ᕷ୰⑓㝔࡟࠾ࡅࡿ⮫ᗋ◊✲άືࡢᨭ᥼
◊✲ศᢸ⪅ ᑿ⸨ ㄔྖ
ᮾி་⒪ࢭࣥࢱ࣮ ᩍ⫱◊ಟ㒊/⮫ᗋ␿Ꮫ◊✲ᐊ ᐊ㛗
◊✲せ᪨
ᕷ୰⑓㝔࡛ࡣࠊ኱Ꮫ⑓㝔࡟ẚ㍑ࡋ࡚ⱝ࠸་ᖌࡀ⮫ᗋ◊✲ࡢ᪉ἲㄽࢆ┤᥋Ꮫࡪᶵ
఍࡟ゐࢀࡿᶵ఍ࡣᑡ࡞࠸ࠋ௒ᅇࡢᡃࠎࡢ┠ⓗࡣࠊデ⒪⛉ࡸ⫋✀ࡢᯟࢆ㉸࠼࡚⮫ᗋ
◊✲ࡢ᪉ἲㄽࢆᏛࡪᶵ఍ࢆᕷ୰⑓㝔ࡢ୰࡟ࠕࢮ࣑ࠖࡢᙧᘧ࡛❧ࡕୖࡆࠊࡑࡢຠᯝࢆ
ほᐹࡍࡿࡇ࡜࡟࠶ࡿࠋᮾி་⒪ࢭࣥࢱ࣮ෆ࡛ࠕ⮫ᗋ◊✲ࢮ࣑ࠖࢆ❧ࡕୖࡆࠊࢮ࣑ཷ
ㅮࡍࡿࡶࡢࢆ་ᖌࡸ⸆๣ᖌ࠿ࡽເࡗࡓࠋ3 㐌㛫࡟୍ᗘ⛬ᗘࡢࢮ࣑ࢆ⥅⥆ⓗ࡟⾜࠺
ࡇ࡜࡛ࠊ㹃࣮ࣛࢽࣥࢢࢆ㏻ࡋ࡚ࡢ⮬ᕫᏛ⩦࡜ࡢ┦஌ຠᯝࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡓࠋᛁ
ࡋ࠸ᕷ୰⑓㝔ࡢ་ᖌ࡟࠾࠸࡚ࡣࠊ௨ୗ࡟ຠ⋡ⓗ࡟Ꮫࡧࢆ⾜࠸ࡘࡘ◊✲ᡂᯝࢆୖࡆ
ࡿ࠿࡜࠸࠺ࡇ࡜ࡀ௒ᚋࡢㄢ㢟࡜࡞ࡿࠋ
A. ◊✲┠ⓗ
⮫ᗋ◊✲ࢆ⾜࠺ሙ࡜ࡋ࡚ࠊ኱Ꮫ࡞࡝ࡢ◊✲ᶵ
㛵ࡼࡾࡶᕷ୰⑓㝔ࡢ࡯࠺ࡀࡍࡄࢀ࡚࠸ࡿ㠃ࡀ
࠸ࡃࡘ࠿࠶ࡿࠋ୍ࡘࡣࠊ⮫ᗋ◊✲࡛ᑐ㇟࡜࡞ࡿ
ᝈ⪅ࡢᩘࡸእⓗጇᙜᛶࡀᕷ୰⑓㝔ࡢ࡯࠺ࡀ㧗
࠸࡛࠶ࢁ࠺࡜⪃࠼ࡽࢀࡿࡇ࡜ࠊࡉࡽ࡟ࡣࠊ◊✲
ࢆ⾜࠺ഃ࡟࡜ࡗ࡚ࡶࠊࣜࢧ࣮ࢳ࣭ࢡ࢚ࢫࢳࣙࣥ
࡟ࡲ࡛Ⓨᒎࡉࡏ࡚࠸ࡃࡇ࡜ࡀ࡛ࡁࡿ᪥ᖖᝎࢇ
࡛࠸ࡿ⮫ᗋⓗ࡞␲ၥࡀ᝿㉳ࡋࡸࡍ࠸≧ἣ࡟࠶
ࡿࡇ࡜࡞࡝ࡀ࠶ࡆࡽࢀࡿࠋ୍᪉ࠊᐇ㝿࡟ࡣᕷ୰
⑓㝔࡛ⱝ࠸་ᖌࡀ⮫ᗋ◊✲ࢆ⾜࠺ࡇ࡜ࡣ㞴ࡋ
࠸ࡋࠊᐇ㝿࡟⮫ᗋ◊✲ࢆάⓎ࡟⾜࠺ᕷ୰⑓㝔ࡢ
་ᖌࡣᑡ࡞࠸ࠋࡇࡢཎᅉ࡜ࡋ࡚ࡣࠊ◊✲࡟㈝ࡸ
ࡍ᫬㛫ࡢ࡞ࡉࡸࠊ◊✲άື࡟ᑐࡍࡿホ౯࡞࡝ࡢ
┦ᑐⓗ࡞ᑠࡉࡉ࡞࡝ࠊ࠸ࡃࡘ࠿ࡢ⌮⏤ࡀ࠶ࡆࡽ
ࢀࡿࡀࠊࡑࡢ୰ࡢ୍ࡘ࡟ࠊ⮫ᗋ◊✲ࢆᐇ᪋ࡍࡿ
࠺࠼࡛ࡢࢫ࢟ࣝࢆᏛ⩦ࡍࡿᶵ఍ࡀ࡞࠸ࡇ࡜ࡀ
࠶ࡿࠋ
☜࠿࡟ᕷ୰⑓㝔࡟ࡣ኱Ꮫ⑓㝔➼ࡢᏛ⾡ᶵ㛵
࡟ẚ㍑ࡋ࡚⮫ᗋ◊✲ࡢ᪉ἲㄽࢆᏛࡪ㈨※ࡣᑡ
࡞࠸࡛࠶ࢁ࠺ࠋࡓࡔࠊ᫖௒ࡢ㹃࣮ࣛࢽࣥࢢ➼ࡢ
ᬑཬ࡟ࡼࡗ࡚ࠊ᝟ሗ㈨※࡟ࡘ࠸࡚ࡣඞ᭹ࡀྍ⬟
࡞≧ែ࡜࡞ࡾࡘࡘ࠶ࡿࠋ࠶࡜ࡣேⓗ㈨※࡛࠶ࡿ
ࡀࠊᕷ୰⑓㝔࡛ࡣデ⒪⛉㛫ࡸ⫋✀㛫ࡢᇉ᰿ࡀ┦
ᑐⓗ࡟పࡃࠊᑠࡉ࡞ࢢ࣮ࣝࣉࢆゐᡭᶓ᩿ⓗ࡟ᵓ
ᡂࡍࡿࡇ࡜࡛ࠊࣁࣥࢬ࡛࢜ࣥ⮫ᗋ◊✲ࡢ᪉ἲㄽ
ࢆᏛࡪሙࢆタࡅࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
௒ᅇࡢ┠ⓗࡣࠊᮾி་⒪ࢭࣥࢱ࣮࡟໅ົࡍࡿ
་ᖌࢆ୰ᚰ࡜ࡋࡓ་⒪ᑓ㛛⫋ࢆᑐ㇟࡟ࠊ㹃࣮ࣛ
ࢽࣥࢢ࡟ࡼࡿᏛ⩦ࢆಶู࡟⾜࠸࡞ࡀࡽࠊಶேಶ
ேࡀ❧᱌ࡋࡓ◊✲ィ⏬ࢆࣁࣥࢬ࡛࢜ࣥ㆟ㄽࡍ
ࡿࠕࢮ࣑ࠖᘧࡢሙࢆタࡅࡿࡇ࡜ࡀࠊⱝᡭ་⒪⫋
ࡢ⮫ᗋ◊✲᥎㐍࡟ᐤ୚ࡍࡿ࠿࡝࠺࠿࡟ࡘ࠸࡚
ࡢ࢔ࢡࢩ࣭ࣙࣥࣜࢧ࣮ࢳࢆ⾜࠺ࡇ࡜࡛࠶ࡿࠋ
B. ◊✲᪉ἲ
◊✲ࢹࢨ࢖ࣥ㸸࢔ࢡࢩ࣭ࣙࣥࣜࢧ࣮ࢳ
ᑐ㇟⪅㸸ᮾி་⒪ࢭࣥࢱ࣮࡟໅ົࡍࡿ་⒪⫋ဨ
ࢮ࣑⏕࡬ࡢⓏ㘓㸸2014 ᖺ 1 ᭶࡟ᮾி་⒪ࢭࣥ
ࢱ࣮་⒪ᑓ㛛⫋⫋ဨ࡟ࢮ࣑࡬ࡢධ㒊ࢆ࿧ࡧ࠿
ࡅࡓࠋ
ࢮ࣑ࡢෆᐜ㸸2014 ᖺ 4 ᭶࡟㹃࣮ࣛࢽࣥࢢࢩࢫ
ࢸ࣒ࡀ㛤ጞࡉࢀࡿࡇ࡜࡟క࠸ࢮ࣑ࢆ㛤ጞࡋࡓࠋ
ࢮ࣑ࡣࠊ㹃࣮ࣛࢽࣥࢢࡀ⾜ࢃࢀ࡚࠸ࡿ 4 ᭶࠿ࡽ
㸵᭶࡟࠿ࡅ࡚ࡣ 3 㐌㛫࡟୍ᗘࡢ㢖ᗘ࡛⾜࠸ࠊ㸶
᭶࠿ࡽࡣ 5 㐌㛫࡟୍ᗘ⛬ᗘࡢ㢖ᗘ࡛⾜ࡗࡓࠋࢮ
࣑ࡢෆᐜࡣࠊ๓༙࡟ࡘ࠸࡚ࡣ㹃࣮ࣛࢽࣥࢢࢥࣥ
―3―
ࢸࣥࢶࡢゎㄝ࡜ࠊࢮ࣑⏕ࡑࢀࡒࢀࡢ㐍ᤖࡢሗ࿌ࠊ
࠾ࡼࡧ㐍ᤖ≧ែ࡟ᑐࡍࡿ┦஫ࡢࣇ࢕࣮ࢻࣂࢵ
ࢡࢆ⾜ࡗࡓࠋ
ホ౯㡯┠㸸௨ୗࢆࠊࢮ࣑⏕ࡢ◊✲άື࡟㛵ࡍࡿ
ᣦᶆ࡜ࡋࡓࠋ
࣭ ◊✲௬ㄝࢆタᐃࡋࡓࢮ࣑⏕ࡢ๭ྜ
࣭ 㹃࣮ࣛࢽࣥࢢࢆ᏶㐙ࡋࡓࢮ࣑⏕ࡢ๭ྜ
࣭ ೔⌮ጤဨ఍࡟◊✲ィ⏬᭩ࢆᥦฟࡋࡓࢮ࣑
⏕ࡢ๭ྜ
࣭ ࢹ࣮ࢱ཰㞟࡜ศᯒࢆ⤊஢ࡋࡓࢮ࣑⏕ࡢ๭
ྜ
࣭ Ꮫ఍࡟ᢒ㘓ࢆᥦฟࡋࡓࢮ࣑⏕ࡢ๭ྜࠋ
㸦೔⌮㠃࡬ࡢ㓄៖㸧
ᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ⑓㝔࡟࠾ࡅࡿ⮫ᗋ◊✲
ᇶ┙᥎㐍ࡑࡢࡶࡢࢆ┠ⓗ࡟ࡋ࡚࠸ࡿࡶࡢ࡛࠶
ࡾࠊ࢔ࢡࢩࣙࣥ⮬యࡢ୺┠ⓗࡣ◊✲࡛ࡣ࡞ࡃ
ᩍ⫱ࡑࡢࡶࡢ࡟࠶ࡿࡓࡵࠊᮏ஦ᴗ⮬య࡟ࡘ࠸
࡚ࡢ೔⌮ᑂᰝጤဨ఍࡬ࡢ⏦ㄳࡣ⾜ࡗ࡚࠸࡞
࠸ࠋ୍᪉ࠊࡇࡢㄪᰝ࡛グ㏙ࡍࡿࡶࡢࡣ࠶ࡃࡲ
࡛ࡶ㞟ᅋ๭ྜࡢࡳ࡛࠶ࡾࠊࢮ࣑⏕୍ே୍ேࡢ
ಶ⚊ࢆࢹ࣮ࢱ໬ࡍࡿࡇ࡜ࡣ⾜ࡗ࡚࠸࡞࠸ࠋࡑ
ࡢࡓࡵࠊಶே᝟ሗ࡟࡞ࡾ࠺ࡿࢹ࣮ࢱࡣ⏕ᡂࡉ
ࢀ࡚࠸࡞࠸ࠋ
C. ◊✲⤖ᯝ
ࢮ࣑⏕ࡢⓏ㘓㸸10 ྡࡢࢮ࣑⏕࡜ 2 ྡࡢ࣓ࣥࢱ
࣮ࢆⓏ㘓ࡋࡓࠋࢮ࣑⏕ࡢ࠺ࡕࠊ8 ྡࡣ་ᖌ࡛࠶
ࡾࠊ㸯ྡࡣ⸆๣ᖌࠊ㸯ྡࡣ⌮Ꮫ⒪ἲኈ࡛࠶ࡗࡓࠋ
ࢮ࣑ࡢ㛤ദ㸸ࢮ࣑ࡣィ⏬࡟‽ࡌ࡚㛤ദࡉࢀࡓࠋ
ẖᅇࡢࢮ࣑࡬ࡢฟᖍࡢ୰ኸ್ࡣ㸲ྡ࡛࠶ࡗࡓࠋ
ࢮ࣑⏕ࡢάືᛶᣦᶆ㸸ࡑࢀࡒࢀࡢᣦᶆࡣ௨ୗࡢ
ࡶࡢ࡛࠶ࡗࡓࠋ
࣭ ◊✲௬ㄝࢆタᐃࡋࡓࢮ࣑⏕ࡢ๭ྜ㸸㸵ྡ
㸦70㸣㸧
࣭ 㹃࣮ࣛࢽࣥࢢࢆ᏶㐙ࡋࡓࢮ࣑⏕ࡢ๭ྜ㸸6
ྡ㸦60㸣㸧
࣭ ೔⌮ጤဨ఍࡟◊✲ィ⏬᭩ࢆᥦฟࡋࡓࢮ࣑
⏕ࡢ๭ྜ㸸4 ྡ㸦40㸣㸧
࣭ ࢹ࣮ࢱ཰㞟࡜ศᯒࢆ⤊஢ࡋࡓࢮ࣑⏕ࡢ๭
ྜ㸸2 ྡ㸦20㸣㸧
࣭ Ꮫ఍࡟ᢒ㘓ࢆᥦฟࡋࡓࢮ࣑⏕ࡢ๭ྜ㸸0 ྡ
㸦0㸣㸧
D. ⪃ᐹ
ᐇᆅ⮫ᗋ࡟࠸ࡑࡋࡴᕷ୰⑓㝔࡛ࡢⱝ࠸་ᖌ
࡟࡜ࡗ࡚ࠊ⮫ᗋ◊✲ࢆ᏶㐙ࡍࡿ࡟ࡣ࠸ࡃࡘࡶࡢ
㧗࠸ࣁ࣮ࢻࣝࡀ࠶ࡿࠋ௒ᅇࡢ㹃࣮ࣛࢽࣥࢢࢩࢫ
ࢸ࣒ࡢᥦ౪࡜࡜ࡶ࡟㛤ദࡉࢀࡓࢮ࣑ᙧᘧ࡛ࡢ
ࣁࣥࢬ࢜ࣥࢺ࣮ࣞࢽࣥࢢࡣࠊᙼዪࡽ࡟࠸ࡃࡘ࠿
ࡢຠᯝࢆࡶࡓࡽࡋࡓ࡜⪃࠼ࡽࢀࡿࠋ➨୍࡟ࡣࠊ
ᐃᮇⓗ࡟ྠࡌࡼ࠺࡟ᅔ㞴ࢆឤࡌ࡚࠸ࡿ௰㛫ࡢ
㐍ᤖࡸၥ㢟Ⅼ࡟ࡘ࠸࡚ඹ᭷ࡍࡿࡇ࡜࡛ࠊ࡜ࡶ࡟
㞴㢟ࢆ஌ࡾ㉺࠼࡚࠸ࡇ࠺࡜࠸࠺ᩥ໬ࡀ⏕ࡲࢀ
࡚ࡃࡿ࡜࠸࠺ࡇ࡜࡛࠶ࡿࠋࡶ࠺୍Ⅼࡣࠊ࢖ࣥࢱ
࣮ࢿࢵࢺࢆ㏻ࡌࡓࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࡔࡅ࡛
ࡣ࡞࠿࡞࠿ࢽࣗ࢔ࣥࢫࡀఏࢃࡽ࡞࠸␲ၥࡸၥ
㢟࡟ࡘ࠸࡚ࠊከேᩘ࡛㆟ㄽࢆࡍࡿࡇ࡜࡛▱㆑ࡸ
⪃࠼᪉ࡢᩚ⌮ࡀ࡛ࡁࡿ࡜࠸࠺ࡇ࡜࡛࠶ࡿࠋ௒ᅇ
ࡢࢮ࣑࡛ࡣࠊ௨ୖࡢࡼ࠺࡞Ⅼ࡟ࡘ࠸࡚ࡣ☜࠿࡟
Ⰻ࠸ຠᯝࢆࡶࡓࡽࡋ࡚࠸ࡓ࡜⪃࠼ࡽࢀࡓࠋ
୍᪉࡛ࠊṧᏑࡍࡿၥ㢟Ⅼ࡜ࡋ࡚ࡣࠊࡸࡣࡾࢱ
࢖࣒࣐ࢿࢪ࣓ࣥࢺࡢၥ㢟࡛࠶ࡿࠋ㹃࣮ࣛࢽࣥࢢ
ࢆཷㅮࡋࡓࡾࠊᐟ㢟ࢆᥦฟࡍࡿ࡜ࡇࢁࡲ࡛ࡣࠊ
ఱ࡜࠿᫬㛫ࢆ᤬ฟࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡀࠊᐇ㝿࡟
ィ⏬ࡉࢀࡓ◊✲ࢆᐇ⾜࡟⛣ࡋࡓࡾࠊࢹ࣮ࢱࡢ཰
㞟ࢆ⾜࠺࡜࠸࠺ࡇ࡜ࡣࠊᛁࡋ࠸୍⯡⑓㝔ࡢ་⒪
⫋࡟࡜ࡗ࡚ࡣࡸࡣࡾ㞴㢟࡛࠶ࡿࠋࡇࢀࡽࡢㄢ㢟
ࢆゎỴࡍࡿ࠺࠼࡛ࡢ௒ᚋࡢᥦ᱌ࡣࠊ๓ྥࡁࢥ࣍
࣮ࢺ◊✲ࡢࡼ࠺࡞ከ኱࡞ປຊࡀ࠿࠿ࡿ◊✲ࢆ
㑊ࡅࠊ㟁Ꮚ࢝ࣝࢸࡸ㹂㹎㹁ࢹ࣮ࢱ࡞࡝ࠊ᪥ࠎࡢ
デ⒪ࢆ㏻ࡌ࡚⑓㝔᝟ሗࢩࢫࢸ࣒࡟᱁⣡ࡉࢀࡿ
⮫ᗋࢹ࣮ࢱࢆ᭷ຠ࡟◊✲┠ⓗ࡟஧ḟ฼⏝ࡍࡿ
ࡇ࡜࡛࠶ࢁ࠺ࠋࡑࢀ࡟ࡼࡗ࡚ࠊ◊✲⪅ࡢ㈇ᢸࡣ
኱ᖜ࡟๐ῶࡉࢀࡿࠋࡓࡔࠊ஧ḟ฼⏝ࡀάⓎ࡟⾜
ࢃࢀࡿࡼ࠺࡟࡞ࡿࡓࡵ࡟ࡣࠊᑓ௵ࡢࢩࢫࢸ࣒࣭
࢚ࣥࢪࢽ࢔ࡸ⤫ィᐙࡀᚲせ࡟࡞ࡗ࡚ࡃࡿࠋ500
ᗋࢆ㉸࠼ࡿつᶍࡢ⑓㝔࡟࠾࠸࡚ࡣࠊ௒ᚋ✚ᴟⓗ
࡟ࡑࡢࡼ࠺࡞ேဨࡢ㞠⏝ࢆ᳨ウࡋ࡚࠸ࡃࡇ࡜
ࡀ᥎ዡࡉࢀࡿࠋ
㹃. ⤖ㄽ
ࢮ࣑ᙧᘧ࡛ࡢࣁࣥࢬ࢜ࣥ࡟ࡼࡿ⮫ᗋ◊✲ࢫ
࢟ࣝࡢᩍ⫱ࣉࣟࢢ࣒ࣛࡣࠊ㝈⏺ࡀ࠶ࡿࡀࠊ㹃
࣮ࣛࢽࣥࢢ࡟ࡼࡿ⮬ᕫᏛ⩦ࢆ⿵᏶ࡍࡿྍ⬟ᛶ
ࡀ♧၀ࡉࢀࡓࠋ
㹅. ◊✲Ⓨ⾲
1. ㄽᩥⓎ⾲
≉グ஦㡯࡞ࡋ
2. Ꮫ఍Ⓨ⾲
≉グ஦㡯࡞ࡋ
㹆.
1.
2.
3.
―4―
▱ⓗ㈈⏘ᶒࡢฟ㢪࣭Ⓩ㘓≧ἣ
≉チྲྀᚓ㸸࡞ࡋ
ᐇ⏝᪂᱌Ⓩ㘓㸸࡞ࡋ
ࡑࡢ௚㸸࡞ࡋ
ࠝ⮫ᗋ␿Ꮫ◊✲ᐊࠞ
ᶆ‽ホ౯㡯┠ࢆ⏝࠸ࡓᆅᇦデ⒪ᡤࡢໟᣓⓗホ౯◊✲
ᯇᮧ┿ྖࠊᑿ⸨ㄔྖ
㸦⮫ᗋ␿Ꮫ◊✲ᐊ㸧
せ ⣙
ࢃࡀᅜ࡟࠾࠸࡚ࠊデ⒪ᣦᶆࢆ⏝࠸ࡓデ⒪ࡢ㉁ホ౯ࡣࠊẚ㍑ⓗつᶍࡢ኱ࡁ࠸⑓㝔࡟࠾࠸࡚ࡣ
⾜ࢃࢀ࡚࠸ࡿࡀࠊࣉࣛ࢖࣐ࣜࢣ࢔ࢆᢸ࠺ᆅᇦࡢデ⒪ᡤ࡛ࡣ࡯࡜ࢇ࡝⾜ࢃࢀ࡚࠸࡞࠸ࠋ௒ᅇࡉ
ࡲࡊࡲ࡞ഃ㠃࡛␗࡞ࡿᆅᇦࡢ 2 デ⒪ᡤ࡟ᑐࡋ࡚ࠊࡇࢀࡲ࡛㛤Ⓨࡋ࡚ࡁࡓデ⒪ᣦᶆࢆ⏝࠸࡚ࠊ
ᆅᇦデ⒪ᡤ࡛ᥦ౪ࡉࢀ࡚࠸ࡿࣉࣛ࢖࣐ࣜࢣ࢔࡟ࡘ࠸࡚ࠊໟᣓⓗ࡞ホ౯ࢆ⾜ࡗࡓࠋホ౯࡟⏝࠸
ࡓデ⒪ᣦᶆࡣᡃࠎࡀ㛤Ⓨࡋࠊ2014 ᖺ࡟ᐇᆅ࡛౑⏝ࡋࡓ 5 ࢝ࢸࢦ࣮ࣜ㸦ᖜᗈ࠸デ⒪࠾ࡼࡧᶆ
‽ⓗデ⒪ࠊ࢔ࢡࢭࢫࠊࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࠊ㐃ᦠࠊᝈ⪅⫼ᬒࡢᑛ㔜㸧
ࠊ42 㡯┠࠿ࡽᵓᡂࡉࢀ
࡚࠸ࡿᣦᶆ࡛࠶ࡿࠋࢹ࣮ࢱ※ࡣ 3 㡯┠ࡀࣞࢭࣉࢺࠊ18 㡯┠ࡀデ⒪㘓ࠊ21 㡯┠ࡀᝈ⪅ㄪᰝ࡛
࠶ࡿࠋ2014 ᖺ 8 ᭶Ɇ2015 ᖺ 7 ᭶ࡢ 1 ᖺ㛫ࢆㄪᰝᮇ㛫࡜ࡋࠊࡇࡢ㛫ࡢ඲デ⒪㘓࠾ࡼࡧࣞࢭࣉ
ࢺࢹ࣮ࢱࢆᑐ㇟࡟⾜ࢃࢀࡓࠋ
ᝈ⪅ㄪᰝࡣ 2015 ᖺ 8 ᭶ࡢࡑࢀࡒࢀ 1 㐌㛫ࡢ඲ཷデᝈ⪅ࢆᑐ㇟࡜ࡋ࡚⾜ࢃࢀࡓࠋ୧デ⒪ᡤ
࡜ࡶ 2-3 ᪥ࡢᐇᆅㄪᰝᮇ㛫࡛デ⒪㘓ㄪᰝࡀ⤊஢ࡋࡓࡀࠊ㝔እฎ᪉ࢆ᥇⏝ࡋ࡚࠸ࡿ B デ⒪ᡤ
࡟࠾࠸࡚ࡣ⌧ᆅ࡛ฎ᪉ෆᐜࢆ☜ㄆࡍࡿᚲせᛶࡀ⏕ࡌࠊࡍ࡭࡚ࡀデ⒪㘓ㄪᰝ࡜࡞ࡗࡓࠋᝈ⪅ㄪ
ᰝࡣ A デ⒪ᡤ 44 ྡࠊB デ⒪ᡤ 126 ྡ࠿ࡽᅇ⟅ࡀᚓࡽࢀࡓࠋࡇࡢ୰࡛ᑜࡡࡽࢀࡓࠕࡇࡢࡼ࠺
࡞࢔ࣥࢣ࣮ࢺㄪᰝࢆᐃᮇⓗ࡟⾜࠺ࡇ࡜ࢆዲࡲࡋࡃᛮ࠺࠿ࠖ࡜࠸࠺㉁ၥ࡟ᑐࡋ࡚ࠊA デ⒪ᡤ࡛
ࡣ 72.7㸣㸦32 ྡ/඲ 44 ྡ㸧ࠊB デ⒪ᡤࡣ 67.5㸣㸦83 ྡ/඲ 123 ྡ㸧ࡀࠕࡑ࠺ᛮ࠺ࠖࠕ኱ኚࡑ
࠺ᛮ࠺ࠖ࡜ከࡃࡢᝈ⪅ࡀ⫯ᐃⓗ࡞ពぢ࡛࠶ࡗࡓࠋࡲࡓࠊࠕᐃᮇⓗ࡟እ㒊ホ౯ࢆཷࡅࡿࡇ࡜࡟
㛵ࡋ࡚ዲࡲࡋ࠸࡜ᛮ࠺࠿ࠖࠊࡢၥ࠸࡟ᑐࡋ࡚ࡶࠊA デ⒪ᡤ࡛ࡣ 72.7㸣㸦32 ྡ/඲ 44 ྡ㸧ࠊB
デ⒪ᡤ࡛ࡣ 72.1㸣㸦88 ྡ/඲ 122 ྡ㸧ࡀࠕࡑ࠺ᛮ࠺ࠖࠕ኱ኚࡑ࠺ᛮ࠺ࠖ࡜ከࡃࡀ⫯ᐃⓗ࡞ព
ぢ࡛࠶ࡗࡓࠋ௒ᅇࡢ◊✲ࢆ㏻ࡌ࡚ࠊ࠸ࡃࡘ࠿ᐇ⾜ୖࡢㄢ㢟ࡣ࠶ࡿࡶࡢࡢࠊࡇࡢࡼ࠺࡞デ⒪ᣦ
ᶆࢆ⏝࠸ࡓデ⒪ᡤ࡟࠾ࡅࡿࣉࣛ࢖࣐ࣜࢣ࢔ࡢホ౯࡟㛵ࡋ࡚ࠊ␗࡞ࡿࣉࣛࢵࢺࣇ࢛࣮࣒࡟࠾
࠸࡚ࡶࡑࡢ᭷ຠᛶ࣭ᐇ⾜ྍ⬟ᛶࡣᚓࡽࢀࡓࡶࡢ࡜⪃࠼ࡽࢀࡓࠋ
┠ ⓗ
ࡀᅜ࡟࠾࠸࡚ࠊデ⒪ᣦᶆࢆ⏝࠸ࡓデ⒪ࡢ㉁ホ౯ࡣࠊつᶍࡢ኱ࡁ࠸⑓㝔࡟࠾࠸࡚ࡣ୍⯡໬ࡋ
ࡘࡘ࠶ࡿࡀࠊࣉࣛ࢖࣐ࣜࢣ࢔ࢆᢸ࠺デ⒪ᡤ࡛ࡣ࡯࡜ࢇ࡝⾜ࢃࢀ࡚࠸࡞࠸ࠋಶࠎࡢデ⒪ᡤࡣࡑ
ࡢᆅ⌮ⓗ࡞఩⨨௜ࡅࠊ୺࡜ࡋ࡚ᥦ౪ࡋ࡚࠸ࡿデ⒪ෆᐜࠊ᪋タつᶍ࡟ࡼࡗ࡚኱ࡁ࡞ᕪ␗ࡀ࠶ࡿ
ࡶࡢࡢࠊࡑࡢ᰾࡜࡞ࡿࣉࣛ࢖࣐ࣜࢣ࢔ᶵ⬟࡟㛵ࡋ࡚ࡣ༢࡟⑌⑓⨯ᝈ᫬ࡢ་⒪ࢧ࣮ࣅࢫࡢᥦ
౪ࢆ⾜࠺࡟࡜࡝ࡲࡽࡎࠊ᪥ᖖࡢண㜵άື࣭೺ᗣቑ㐍ࠊ་⒪࣭௓ㆤ࣭⚟♴ࢧ࣮ࣅࢫࡢㄪᩚࠊᆅ
ᇦࡢேࠎ࡜ࡢ஺ὶࢆ㏻ࡌࡓᆅᇦࡢάᛶ໬࡞࡝ࠊከᒱ࡟ࢃࡓࡿᵝࠎ࡞άືࢆྵࡴ୍ᐃࡢඹ㏻
㒊ศࡀ࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋ
ࡇࢀࡲ࡛ᡃࠎࡣࠊࡇࢀࡽࡢඹ㏻㒊ศ࡟㛵ࡋ࡚ᶆ‽ⓗࣉࣛ࢖࣐ࣜࢣ࢔࡟㛵ࡍࡿデ⒪ᣦᶆࢆ
㛤Ⓨࡋࠊࡇࢀࡽࢆ⏝࠸࡚ᐇ᪋⋡ࢆᐇᆅ࡛ ᐃࡋࣇ࢕࣮ࢻࣂࢵࢡࢆࡍࡿᡭἲࢆ⏝࠸࡚ࠊ୍ᆅᇦ
࡟࠾ࡅࡿ」ᩘࡢデ⒪ᡤ࡟࠾࠸࡚ᐇᆅ࡛㐩ᡂ⋡ࡢ ᐃࢆ⾜࠸ࠊࡑࡢ᭷⏝ᛶ࠾ࡼࡧᐇ⾜ྍ⬟ᛶ
―5―
ࢆ᳨ドࡋ࡚ࡁࡓࠋࡋ࠿ࡋタ❧ẕయࠊ౑⏝ࡍࡿデ⒪㘓ࠊࣞࢭࣉࢺࢥࣥࣆ࣮ࣗࢱ࡞࡝ࡀ␗࡞ࡗ࡚
࠸ࡓሙྜ࡟ࡶᐇ㝿࡟ᐇ᪋ࡀྍ⬟࡛࠶ࡿ࠿࡟ࡘ࠸࡚ࡢ▱ぢࡣ㝈ᐃⓗ࡛࠶ࡗࡓࠋ࡜ࡾࢃࡅࠊ㟁Ꮚ
࢝ࣝࢸࢆ⏝࠸ࡓデ⒪㘓ㄪᰝ࡟ࡣࠊேⓗ࣭᫬㛫ⓗປຊࡀ࠿࠿ࡿࡇ࡜ࡀࡇࢀࡲ࡛ࡢ◊✲࡛᫂ࡽ࠿
࡟࡞ࡗ࡚࠾ࡾࠊࣉࣛ࢖࣐ࣜࢣ࢔࡟࠾ࡅࡿデ⒪ᡤࡢከᵝᛶ࠿ࡽᐇ⾜ྍ⬟ᛶࡀᢸಖࡉࢀࡿࡢ࠿
࡝࠺࠿࡟㛵ࡋ࡚ࡣ୙࡛᫂࠶ࡗࡓࠋ
ᮏ◊✲ࡣࠊ␗࡞ࡿᆅᇦ࣭タ❧ẕయ࣭࢝ࣝࢸ࣭ࣞࢭࣉࢺ࣓࣮࣮࢝ࢆ⏝࠸ࡿᆅᇦࡢ」ᩘࡢデ⒪
ᡤ࡟࠾࠸࡚ᶆ‽ⓗ࡞ࣉࣛ࢖࣐ࣜࢣ࢔࡟㛵ࡍࡿデ⒪ᣦᶆࢆ⏝࠸ࡓࠊデ⒪ホ౯ࢆ⾜࠸ࠊࡑࡢᐇ⾜
ྍ⬟ᛶ࡜௒ᚋࡢㄢ㢟࡟ࡘ࠸᳨࡚ウࡍࡿࡇ࡜ࢆ┠ⓗ࡟ࡋ࡚࠸ࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
௒ᅇᡃࠎࡣ༠ຊデ⒪ᡤ 2 ᪋タ࡟࠾࠸࡚ホ౯◊✲ࢆ⾜ࡗࡓࠋ୧デ⒪ᡤ࡜ࡶ࡟ࠊ㤳㒔ᅪ㏆㑹
ࡢఫᏯᆅ࡟఩⨨ࡋ࡚࠸ࡿࡀࠊ㸿デ⒪ᡤࡣෆ⛉୺య࡛࠶ࡾ㧗㱋⪅ࡢẚ⋡ࡶẚ㍑ⓗከ࠸ᆅᇦ࡛
㛗ᖺ㛤ᴗࡋ࡚࠸ࡿಶே❧ࡢデ⒪ᡤ࡛࠶ࡿࡢ࡟ᑐࡋࠊ㹀デ⒪ᡤࡣᑠඣ⛉ࡢẚ⋡ࡀከࡃ㥐๓ࡢ
ẚ㍑ⓗே㏻ࡾࡢከ࠸ᆅᇦࡢ」ྜࣅࣝෆ࡟఩⨨ࡋ࡚࠾ࡾࠊྠࣅࣝෆ࡟⸆ᒁ࠾ࡼࡧ௚ᑓ㛛⛉ࡢ
デ⒪ᡤࡀ㛤タࡋ࡚࠸ࡿἲே໬ࡉࢀ࡚࠸ࡿẚ㍑ⓗ㛤ᴗᖺᩘࡢ▷࠸デ⒪ᡤ࡛࠶ࡿࠋ౑⏝ࡋ࡚࠸
ࡿ㟁Ꮚ࢝ࣝࢸ࠾ࡼࡧࣞࢭࣉࢺࢥࣥࣆ࣮ࣗࢱࡢ࣋ࣥࢲ࣮ࡶࡑࢀࡒࢀ␗࡞ࡗ࡚࠸ࡿࠋ
ホ౯࡟⏝࠸ࡓデ⒪ᣦᶆࡣᡃࠎࡀ㛤Ⓨࡋࠊࡇࢀࡲ࡛࡟ᐇᆅ࡟࠾࠸࡚౑⏝ࡋ࡚ࡁࡓࣉࣛ࢖࣐
ࣜࢣ࢔࡟㛵ࡍࡿデ⒪ᣦᶆࢆ⏝࠸ࡓࠋࡇࢀࡽࡣ 5 ࢝ࢸࢦ࣮ࣜ㸦ᖜᗈ࠸デ⒪࠾ࡼࡧᶆ‽ⓗデ⒪ࠊ
࢔ࢡࢭࢫࠊࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࠊ㐃ᦠࠊᝈ⪅⫼ᬒࡢᑛ㔜㸧
ࠊ42 㡯┠࠿ࡽᵓᡂࡉࢀ࡚࠸ࡿࠋࡲ
ࡓࢹ࣮ࢱ※ࡣ 3 㡯┠ࡀࣞࢭࣉࢺㄪᰝࠊ18 㡯┠ࡀデ⒪㘓ㄪᰝࠊ21 㡯┠ࡀᝈ⪅ㄪᰝ࡛࠶ࡿࠋㄪ
ᰝᮇ㛫ࡣࠊ2014 ᖺ 8 ᭶Ɇ2015 ᖺ 7 ᭶࡜ࡋࠊࡇࡢᮇ㛫୰ࡢ඲ࣞࢭࣉࢺ࠾ࡼࡧデ⒪㘓ࢹ࣮ࢱࢆ
ᑐ㇟࡜ࡋࡓࠋᝈ⪅ㄪᰝࡣ 2015 ᖺ 8 ᭶ࡢࡑࢀࡒࢀ 1 㐌㛫ࡢཷデᝈ⪅඲ဨࢆᑐ㇟࡜ࡋࡓࠋᝈ⪅
ㄪᰝࡣ⮬ᕫグධᘧࡢ㉁ၥ⣬ࢆ⏝࠸ࡓ࢔ࣥࢣ࣮ࢺㄪᰝ࡛ࠊデ⒪ᡤࡢཷデཷ௜ࡢ㝿࡟グධࡢ༠
ຊࢆ౫㢗ࡋࠊ༠ຊࡀᚓࡽࢀࡓᝈ⪅࡟ᡭΏࡋࢆ⾜࠸ࠊࡑࡢሙ࡛グධࡋᅇ཰ࡍࡿ࠿ࠊᚋ᪥ㄪᰝ஦
ົᒁ࡬ࡢ㒑㏦࠿ࡢ࠸ࡎࢀ࠿ࢆ౫㢗ࡋࡓࠋA デ⒪ᡤࡣ㝔ෆฎ᪉࡛࠶ࡗࡓࡓࡵࠊࣞࢭࣉࢺㄪᰝࡢ
㡯┠ࡣ⸆๣᝟ሗࢆ⏝࠸࡚┤᥋ᐇ᪋⋡ࢆ⟬ฟࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡗࡓࡀࠊB デ⒪ᡤࡣ㝔እฎ
᪉ࡢࡓࡵ⌧ᆅ࡟࠾࠸࡚ฎ᪉ෆᐜࢆ㟁Ꮚ࢝ࣝࢸࡢグ㍕ෆᐜ࡛☜ㄆࢆ⾜࠺సᴗࡀⓎ⏕ࡋࡓࠋデ
⒪㘓ㄪᰝ࡟㛵ࡋ࡚ࡣᮇ㛫ෆ࡟ㄪᰝᑐ㇟ᝈ⪅ࡢศẕࡢୖ㝈ࢆ 100 ྡ࡟タᐃࡋࠊࡇࡢேᩘ࡟㐩
ࡋࡓ᫬Ⅼ࡛ࡑࡢ㡯┠࡟㛵ࡍࡿㄪᰝࡣ⤊஢ࡍࡿࡇ࡜࡜ࡋࡓࠋ
⤖ ᯝ
A デ⒪ᡤ࡛ࡣࣞࢭࣉࢺୖࡢ⸆๣᝟ሗࢆ⏝࠸࡚஦๓ᢳฟࢆ⾜࠺ࡇ࡜ࡀྍ⬟࡛࠶ࡗࡓࡀࠊB デ
⒪ᡤ࡟㛵ࡋ࡚ࡣ㝔እฎ᪉ࡢࡓࡵ⸆๣᝟ሗࢆᢳฟ୙⬟࡜࡞ࡾࠊ⌧ᆅ࡛デ⒪㘓ࢆ☜ㄆࡢୖ┠ど
࡛ヱᙜ⸆ࡀฎ᪉ࡉࢀ࡚࠸ࡓ࠿࡟㛵ࡍࡿ☜ㄆࡀᚲせ࡜࡞ࡗࡓࠋලయⓗ࡟ࡣࣞࢭࣉࢺࢹ࣮ࢱୖ
࡛ࡣฎ᪉ࡀ⾜ࢃࢀࡓࡇ࡜ࡣุ᫂ࡍࡿࡀࠊヱᙜ⸆๣ࡀᐇ㝿࡟ฎ᪉ࡉࢀ࡚࠸ࡿ࠿☜ㄆࡀᚲせ࡜
࡞ࡗࡓࠋලయⓗ࡟ࡣࠊB デ⒪ᡤ࡟࠾ࡅࡿ⌧ᆅㄪᰝ࡛ࡣ㝆ᅽ฼ᒀ๣ࠊ⢾ᒀ⑓⸆ࠊǃ2 ่⃭๣ࡀ
ฎ᪉ࡉࢀ࡚࠸ࡿ࠿ࡢ☜ㄆࡣ 289 ྡࡀࠊ⢾ᒀ⑓⸆࡛ࡣ 57 ྡࡀࠊǃ㸰่⃭๣࡛ࡣ 317 ྡࡢ☜ㄆ
ࡀᚲせ࡜࡞ࡗࡓࠋ
ࡲࡓデ⒪㘓ㄪᰝ࡟࠾࠸࡚ࡶ஦๓࡟ᑐ㇟ᝈ⪅ࢆࣞࢭࣉࢺ࠿ࡽࡢࢹ࣮ࢱࢆ⏝࠸࡚⤠ࡾࡇࢇࡔ
ୖ࡛⌧ᆅㄪᰝࢆ⾜࠺ணᐃ࡟ࡋ࡚࠸ࡓࡀࠊࡇࢀࡽ࡟㛵ࡋ࡚ࡶྠᵝࡢసᴗࡀⓎ⏕ࡋࡓࠋࠕ㝆ᅽ๣
ࢆෆ᭹ࡋ࡚࠸ࡿࡍ࡭࡚ࡢ㧗⾑ᅽᝈ⪅࡟ᑐࡋ࡚ࠊ᭱㏆ࡢ 1 ᖺ㛫࡛ࠊ⏕ά⩦័ᨵၿᣦᑟ㸦ῶ㔞ࠊ
―6―
㐠ື⒪ἲࠊ㣗஦⒪ἲࠊῶሷࠊ⠇㓇ࡢ࠸ࡎࢀ࠿㸧ࡀ⾜ࢃࢀࡓ࠿ࠊデ⒪㘓࡟グ㍕ࡀ࠶ࡿࠖ࡟㛵ࡍ
ࡿ㡯┠࡟࠾࠸࡚ࠊB デ⒪ᡤ࡟࠾ࡅࡿㄪᰝ࡛ࡣࠊ㝆ᅽ๣ࡀฎ᪉ࡉࢀ࡚࠸ࡿ࠿ྰ࠿ࢆㄪᰝࡍࡿࡓ
ࡵ࡟ 371 ྡࡢ࢝ࣝࢸࢆᐇ㝿࡟☜ㄆࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠿ࡗࡓࠋ
ࡑࢀࡒࢀࡢ㡯┠࡛ࡢᐇ᪋⋡ࡣ A デ⒪ᡤ࡛ࡣ 4.4㸣㹼69.0㸣ࠊB デ⒪ᡤ࡛ࡣ 0㸣㹼94.6㸣࡜
኱ࡁ࡞ࡤࡽࡘࡁࡀ࠶ࡗࡓࠋࡲࡓࠊA デ⒪ᡤ࡜ B デ⒪ᡤ࡛ࡣࠊㄆ▱⑕ᝈ⪅࡬ࡢ୺௓ㆤ⪅ࡢྠ
ᐃ㸦A デ⒪ᡤ 30% vs B デ⒪ᡤ 81.8㸣㸧ࠊ୺἞་ពぢ᭩ࢆグ㍕ࡋࡓᝈ⪅࡟㛵ࡍࡿࢣ࢔࣐ࢿࢪ
࣮ࣕࡢグ㍕㸦A デ⒪ᡤ 8.1㸣 vs B デ⒪ᡤ 94.6%㸧࡜ࠊ௓ㆤ⪅ࡢྠᐃ࡛ࡣ B デ⒪ᡤࡢᐇ᪋
⋡ࡀ㧗࠿ࡗࡓࡀࠊ୍᪉ࠊ᪂つ㢌③Ⓨ⑕ᝈ⪅࡟࠾ࡅࡿⓎ⑕ᵝᘧࡢグ㍕㸦A デ⒪ᡤ 58.3㸣 % vs
B デ⒪ᡤ 3 㸣㸧,᪂つ⭜③ᝈ⪅࡬ࡢ㤿ᑿ⑕ೃ⩌ࡢ☜ㄆ㸦A デ⒪ᡤ 12㸣ࠊB デ⒪ᡤ 1.3㸣㸧࡜
ྠ୍㡯┠ෆ࡟࠾࠸࡚ࡇࡢ 2 デ⒪ᡤࡢ㛫࡛ࡶ኱ࡁ࡞ᕪ␗ࡀㄆࡵࡽࢀࡓࠋ
ᝈ⪅ㄪᰝࡣ A デ⒪ᡤ 44 ྡࠊB デ⒪ᡤ 126 ྡ࠿ࡽ㏉⟅ࡀᚓࡽࢀࡓࠋࡇࡢ୰࡛ᑜࡡࡽࢀ
ࡓࠊ
ࠕࡇࡢࡼ࠺࡞࢔ࣥࢣ࣮ࢺㄪᰝࢆᐃᮇⓗ࡟⾜࠺ࡇ࡜ࢆዲࡲࡋࡃᛮ࠺࠿ࠖࠊ࡜࠸࠺㉁ၥ࡛ࡣࠊ
A デ⒪ᡤ࡛ࡣ 72.7㸣㸦32 ྡ/඲ 44 ྡ㸧ࠊB デ⒪ᡤࡣ 67.5㸣㸦83 ྡ/඲ 123 ྡ㸧ࡀࠕࡑ࠺ᛮ
࠺ࠖ
ࠕ኱ኚࡑ࠺ᛮ࠺ࠖ࡜⟅࠼࡚࠾ࡾࠊᝈ⪅ࡢከࡃࡀ⫯ᐃⓗ࡞ពぢ࡛࠶ࡗࡓࠋࡲࡓࠊ
ࠕᐃᮇⓗ࡟
እ㒊ホ౯ࢆཷࡅࡿࡇ࡜࡟㛵ࡋ࡚ዲࡲࡋ࠸࡜ᛮ࠺࠿ࠖࠊࡢၥ࠸࡟ᑐࡋ࡚ࡶࠊA デ⒪ᡤ࡛ࡣ 72.7㸣
㸦32 ྡ/඲ 44 ྡ㸧ࠊB デ⒪ᡤ࡛ࡣ 72.1㸣㸦88 ྡ/඲ 122 ྡ㸧ࡀࠕࡑ࠺ᛮ࠺ࠖ
ࠕ኱ኚࡑ࠺ᛮ࠺ࠖ
࡜ከࡃࡀ⫯ᐃⓗ࡞ពぢ࡛࠶ࡗࡓࠋࠖ
ᮏ◊✲ࡢ⤖ᯝ࠿ࡽࠊ␗࡞ࡿ㟁Ꮚ࢝ࣝࢸ࣭ࣞࢭࣉࢺࢥࣥࣆ࣮ࣗࢱࠊ࠾ࡼࡧ␗࡞ࡿ❧ᆅ᮲௳ୗ
࡟࠾࠸࡚ࠊ୍ᐃࡢㄢ㢟ࡣ࠶ࡿࡶࡢࡢࠊࡇࢀࡲ࡛࡟㛤Ⓨࡋࡓデ⒪ᣦᶆࢆ⏝࠸ࡓࣉࣛ࢖࣐ࣜࢣ࢔
ࡢデ⒪ホ౯ࡣᐇ⾜ྍ⬟࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
⾲㸯 ᑐ㇟᪋タࡢ≉ᚩ
㸿デ⒪ᡤ
㹀デ⒪ᡤ
ᡤ ᅾ ᆅ
ᮾி㒔
༓ⴥ┴
タ
ಶ ே
་⒪ἲே
タ ❧ ᖺ
᫛࿴ 44 ᖺ㸦1969 ᖺ㸧
ᖹᡂ 13 ᖺ㸦2001 ᖺ㸧
ᶆ ᴶ ⛉
ෆ⛉࣭ᑠඣ⛉
ᑠඣ⛉࣭ෆ⛉࣭⫶⭠⛉
ᙧ ែ
ᡞᘓ࡚ࠊ⫋ఫ୍యᆺ
ࣅࣝデ⒪ᡤ
㝔ෆฎ᪉
㝔እฎ᪉
㸿♫㸦ࣞࢭࢥࣥ㐃ືᆺ㸧
㹀♫㸦ࣞࢭࢥ୍ࣥయᆺ㸧
ฎ
❧
᪉
ẕ
ᙧ
య
ែ
౑⏝㟁Ꮚ࢝ࣝࢸ࣓࣮࣮࢝
―7―
―8―
―9―
᪂つࡢ㧗⾑ᅽᝈ⪅࡟ࡘ࠸࡚ึデ᫬࡟⢾ᒀ⑓࣭⬡㉁␗ᖖ⑕ࡢ᭷
↓ࠊᚰ㡢࡟ࡘ࠸࡚グ㍕ࡀ࠶ࡿ
㝆ᅽ๣ࢆෆ᭹ࡋ࡚࠸ࡿࡍ࡭࡚ࡢ㧗⾑ᅽᝈ⪅࡟ᑐࡋ࡚ࠊ᭱㏆ࡢ 1
ᖺ㛫࡛ࠊ⏕ά⩦័ᨵၿᣦᑟ㸦ῶ㔞ࠊ㐠ື⒪ἲࠊ㣗஦⒪ἲࠊῶ
ሷࠊ⠇㓇ࡢ࠸ࡎࢀ࠿㸧ࡀ⾜ࢃࢀࡓ࠿ࠊデ⒪㘓࡟グ㍕ࡀ࠶ࡿ
ࡍ࡭࡚ࡢ㧗⾑ᅽᝈ⪅࡟ᑐࡋ࡚ࠊᐙᗞ⾑ᅽ ᐃ⤖ᯝࡢグ㍕ࡀ࠶
ࡿ
ࡍ࡭࡚ࡢ⢾ᒀ⑓ᝈ⪅࡟ࡘ࠸࡚ཷデẖࡢ⾑ᅽࡀ ᐃࡉࢀ࡚࠸
ࡿࠋ
ࡍ࡭࡚ࡢ⢾ᒀ⑓ᝈ⪅ࡣ㐣ཤ 1 ᖺ௨ෆ࡟║⛉࡬⤂௓ࡀ⾜ࢃࢀ࡚
࠸ࡿࠊ࠶ࡿ࠸ࡣ║⛉㏻㝔ࡀ☜ㄆ࡛ࡁ࡚࠸ࡿ
ࡍ࡭࡚ࡢ⢾ᒀ⑓ᝈ⪅ࡣ㐣ཤ 1 ᖺ௨ෆ࡟㊊ࡢデᐹ㸦ࣔࣀࣇ࢕ࣛ
࣓ࣥࢺ࠶ࡿ࠸ࡣ᣺ືぬ㸧ࡀ⾜ࢃࢀ࡚࠸ࡿ
ᡂேẼ⟶ᨭႍᜥᝈ⪅࡟ࡘ࠸࡚ࠊ᭱㏆ࡢ 1 ᖺ㛫࡛㹎㹃㹄㸦ࣆ࣮
ࢡࣇ࣮ࣟ㸧್ࡢグ㍕ࡀ࠶ࡿ
㧗⾑ᅽ࣭⬡㉁␗ᖖ⑕࡟࡚㐣ཤ 12 ࢝᭶࡟ 4 ᅇ௨ୖ㏻㝔ࡋฎ᪉ࢆ
ཷࡅ࡚࠸ࡿᝈ⪅࡟ࡘ࠸࡚ࠊ1 ᖺ࡟ 1 ᅇ௨ୖࠊ௚㝔ࡶྵࡵࡍ࡭
࡚ࡢෆ᭹ฎ᪉⸆࡟ࡘ࠸࡚☜ㄆࡋグ㘓ࡋ࡚࠸ࡿ
㐣ཤ 12 ࢝᭶⥅⥆ࡋ࡚㧗⾑ᅽ࣭⬡㉁␗ᖖ⑕࣭⢾ᒀ⑓ࡢྠ୍⑌ᝈ
࡟࡚㏻㝔୰ࡢᝈ⪅࡟ࡘ࠸࡚ࠊᶆⓗ⑌ᝈ࡟ᑐࡍࡿ⸆๣ࡀኚ᭦࡟
࡞ࡗࡓḟࡢデᐹ᫬࡟ࠊኚ᭦⸆๣࡟㛵ࡍࡿ๪స⏝࣭ຠᯝ࡟ࡘ࠸
࡚グ㍕ࡀ࠶ࡿ
デ⒪᝟ሗᥦ౪᭩࡟ࡣ᪤ Ṕ࣭࢔ࣞࣝࢠ࣮Ṕ࣭⌧ᅾࡢฎ᪉⸆ࡀ
ࡍ࡭࡚グ㍕ࡉࢀ࡚࠸ࡿ
୺἞་ពぢ᭩ࢆⓎ⾜ࡋࠊせ௓ㆤㄆᐃࢆ࠺ࡅࡓᝈ⪅࡟ࡘ࠸࡚ࠊ
デ⒪㘓࡟⌧ᅾࡢᢸᙜࢣ࢔࣐ࢿࢪ࣮ࣕࡀ㸦ࢣ࢔࣐ࢿࢪ࣮ࣕ୙ᅾ
ࡶྵࡵ㸧グ㍕ࡉࢀ࡚࠸ࡿ
ᐃᮇⓗ࡟㏻㝔㸦1 ᖺ࡟ 3 ᗘ௨ୖࡢ㏻㝔ࡀ 3 ᖺ௨ୖ⥆࠸࡚࠸
ࡿ㸧ࡋ࡚࠸ࡿ 20 ṓ௨ୖࡢᡂேᝈ⪅࡟ࡘ࠸࡚ࠊྠᒃᐙ᪘ࡢ᭷
↓ࠊ⫋ᴗ(⏕άୖࡢᙺ๭)࡟ࡘ࠸࡚グ㍕ࡀ࠶ࡿ
― 10 ―
83
83
68
1
1.5
371
108
100
15
15.
0
100
100
100
16
73
73
73
45
73
73
73
14
73
73
73
15
317
317
80
3
3.7
78
78
76
47
61.
8
282
282
66
4
6.1
100
100
99
0
0.0
Ɇ
37
37
35
94.
6
100
100
100
52
52.
0
16.
0
61.
6
19.
2
20.
6
ࠝ⮫ᗋ␿Ꮫ◊✲ᐊࠞ
⬤ᙅ㧗㱋⪅ࡢデ⒪᝟ሗᥦ౪᭩ࣇ࢛࣮࣐ࢵࢺ㛤Ⓨ࡟㛵ࡍࡿ
࢖ࣥࢱࣅ࣮ࣗㄪᰝ
ᯇᮧ┿ྖ㸯ࠊᑿ⸨ㄔྖ㸯ࠊ᪂᳃ຍዉᏊ㸯
㸦⮫ᗋ␿Ꮫ◊✲ᐊ㸧
せ ⣙
ࢣ࢔⛣⾜ Care transition ࡜ࡣࠊ἞⒪ࡸࢣ࢔ࡀ⾜ࢃࢀ࡚࠸ࡿሙᡤࡀኚ໬ࡍࡿࡇ࡜ࢆࡉࡋࠊ
୍⯡࡟ࡣᛴᛶᮇ⑓㝔࡬ࡢධ㏥㝔ࡸࠊ᪋タ࡬ࡢධ㏥ᡤࠊ࡞࡝ࡢࡇ࡜ࢆ⾲ࡋ࡚࠸ࡿࠋࡇࢀࡽࡢ࠺
ࡕࠊᝈ⪅ࡢ≧ែࡀᝏ໬ࡋࠊ἞⒪ࡀ㞟୰ⓗ࡟⾜ࢃࢀࡿᚲせᛶࡀ⏕ࡌ࡚ᛴᛶᮇ⑓㝔࡟ධ㝔ࡍࡿ㝿
࠾ࡼࡧࠊ἞⒪ࡀ⤊஢ࡋ⮬Ꮿ࠶ࡿ࠸ࡣ᪋タ࡬㏥㝔ࡋࡓࡢࡕ⥅⥆἞⒪ࡀᚲせ࡟࡞ࡿ㝿࡟ከࡃࡢ
ၥ㢟ࡀⓎ⏕ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡿࠋ
ᮏ◊✲࡛ࡣࠊ࡜ࡾࢃࡅせ௓ㆤ㸰⛬ᗘ௨ୖࡢ⬤ᙅ㧗㱋⪅ࡀᚰ୙඲ࠊ⫵⅖㸪⬻⾑⟶㞀ᐖࠊᒀ㊰
ឤᰁ⑕࡞࡝ࡢᛴᛶᮇ⑌ᝈ࡟ࡼࡾձᛴᛶᮇ⑓㝔࡟ධ㝔ࡍࡿ㝿,㔜せ࡜ᛮࢃࢀࡿデ⒪᝟ሗ࠾ࡼࡧ
⏕ά࣭ࢣ࢔᝟ሗࠊ࠾ࡼࡧղ⑌ᝈࡀ㍍ᛌࡋࠊᛴᛶᮇ⑓㝔࠿ࡽ㏥㝔ࡍࡿ㝿࡟㔜せ࡜ᛮࢃࢀࡿデ⒪
᝟ሗ࠾ࡼࡧ⏕ά࣭ࢣ࢔᝟ሗ࡜ࡣఱ࠿ࠊࡉࡽ࡟ճࡇࢀࡽࡢ᝟ሗࡀ㏻ᖖࡢデ⒪᝟ሗᥦ౪᭩࡟ຍࢃ
ࡾ௜ຍⓗ࡞᝟ሗࣇ࢛࣮࣐ࢵࢺࡀసᡂࡉࢀࡿࡇ࡜࡟ࡼࡗ࡚ࠊᨵၿࡀᮇᚅࡉࢀࡿධ㝔୰ࡢデ⒪࣭
ࢣ࢔ෆᐜ࠾ࡼࡧ㏥㝔ᚋࡢデ⒪࣭ࢣ࢔ෆᐜ࡟ࡣ࡝ࡢࡼ࠺࡞ࡶࡢࡀ࠶ࡿ࠿ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜
ࢆ┠ⓗ࡜ࡋࡓࠋ
┠ ⓗ㸦ࡲࡓࡣ◊✲┠ⓗ㸧
㧗㱋ேཱྀࡀ⥲ேཱྀࡢ 20㸣ࢆ㉺࠼ࠊࡉࡽ࡟ቑຍࢆ⥆ࡅ࡚࠸ࡿ⌧ᅾࠊᅾ㝔᪥ᩘࡢ▷⦰࡜㏥㝔
࡟ࡴࡅࡓ᪩ᮇ࠿ࡽࡢㄪᩚࡣ་⒪ᶵ㛵ࠊ࡜ࡾࢃࡅᛴᛶᮇ⑓㝔࡟࠾࠸࡚ࡣᴟࡵ࡚㔜せ࡞ၥ㢟࡟
࡞ࡗ࡚ࡁ࡚࠸ࡿࠋࡲࡓࠊ⑌⑓ࡢ៏ᛶ໬࣭」㞧໬ࠊ࠾ࡼࡧᝈ⪅୍ே࡟࠿࠿ࢃࡿ་⒪࣭⚟♴࣭௓
ㆤ⫋࡞࡝ࡢከேᩘ໬࡟ࡼࡾࠊ་⒪᝟ሗ࡜࡜ࡶ࡟ࠊࢣ࢔యไࡢ☜❧࡟ᚲせ࡞ໟᣓⓗ㧗㱋⪅ᶵ⬟
ホ౯ࠊAdvance care planning ࡢྲྀᚓ≧ἣ࡞࡝ࠊ⒪㣴ୖ࣭௓ㆤୖ࡟୙ྍḞ࡞ࡉࡲࡊࡲ࡞᝟ሗ
ࡀồࡵࡽࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁ࡚࠸ࡿࠋࡇࢀࡽࡣ㏻ᖖࠊᝈ⪅࡟㛵ࢃࡿ」ᩘࡢᑓ㛛⫋ࡢ㛫࡛ಶู
࡟ྲྀᚓࡉࢀࠊࡇࢀࡽࡢ᝟ሗࡢከࡃࡣࠊධ㏥㝔ࡸ᪋タධᡤ࡞࡝ࡢ㝿ࡑࡢ㒔ᗘ᩿∦ⓗ࡟ྲྀᚓ࣭⵳
✚ࡉࢀ࡚࠸ࡗ࡚࠸ࡿࡢࡀᐇ᝟࡛࠶ࡿࠋ
ࢣ࢔⛣⾜ Care transition ࡜ࡣࠊ἞⒪ࡸࢣ࢔ࡀ⾜ࢃࢀ࡚࠸ࡿሙᡤࡀኚ໬ࡍࡿࡇ࡜ࢆࡉࡋࠊ
୍⯡࡟ࡣᛴᛶᮇ⑓㝔࡬ࡢධ㏥㝔ࡸࠊ᪋タ࡬ࡢධ㏥ᡤࠊ࡞࡝ࡢࡇ࡜ࢆ⾲ࡋ࡚࠸ࡿࠋࡇࢀࡽࡢ࠺
ࡕࠊᝈ⪅ࡢ≧ែࡀᝏ໬ࡋࠊ἞⒪ࡀ㞟୰ⓗ࡟⾜ࢃࢀࡿᚲせᛶࡀ⏕ࡌ࡚ᛴᛶᮇ⑓㝔࡟ධ㝔ࡍࡿ㝿
࠾ࡼࡧࠊ἞⒪ࡀ⤊஢ࡋ⮬Ꮿ࠶ࡿ࠸ࡣ᪋タ࡬㏥㝔ࡋࡓࡢࡕ⥅⥆἞⒪ࡀᚲせ࡟࡞ࡿ㝿࡟ከࡃࡢ
ၥ㢟ࡀⓎ⏕ࡍࡿࠋ
୍⯡ⓗ࡟ධ㝔᫬࡟ࡣࡇࢀࡲ࡛ࡢᝈ⪅ࡢ㌟య≧ἣࡸ⌧⑓Ṕࠊ᪤ Ṕࠊ᭹⸆≧ἣࠊ࢔ࣞࣝࢠ࣮
Ṕ࡞࡝᝟ሗࢆ୺య࡜ࡍࡿデ⒪᝟ሗᥦ౪᭩ࡀ࠿࠿ࡾࡘࡅ་࡟ࡼࡾᥦ౪ࡉࢀࡿࡇ࡜ࡀ୍⯡ⓗ࡛
࠶ࡿࡀࠊ㧗㱋⪅࡟࠾࠸࡚ࡣᝈ⪅ࢆ࡜ࡾࡲࡃ⎔ቃࡢ」㞧໬࡟ࡼࡾࠊ་ᖌࡢࡳ࡞ࡽࡎࢣ࢔࣐ࢿࢪ
࣮ࣕࡸ௓ㆤࢫࢱࢵࣇࠊ᫬࡟ࡣゼၥ┳ㆤᖌ࣭⸆๣ᖌ࣭⒪ἲኈ࡞࡝ࡢࡉࡲࡊࡲ࡞ᑓ㛛⫋࠿ࡽࡢ᝟
ሗࡶ἞⒪࡟ࡣ㔜せ࡟࡞ࡿࡇ࡜ࡶከ࠸ࠋᝈ⪅࡟ᥦ౪ࡉࢀࡿ἞⒪ࡸࢣ࢔ࡣࠊ἞⒪ࢆᥦ౪ࡍࡿሙࡀ
␗࡞ࡗࡓ࡜ࡋ࡚ࡶࠊ㐃⥆ᛶࢆࡶࡗ࡚෇⁥࡟⥅⥆ࡋ࡚ᥦ౪ࡉࢀࡿᚲせࡀ࠶ࡿࡀࠊࡑࡢࡓࡵ࡟ࡣࠊ
― 11 ―
᪥ࡈࢁ࠿ࡽࡢᝈ⪅ࡢ㑅ዲࠊ౯್ឤ࡞࡝ࡢᝈ⪅ᅛ᭷ࡢ᝟ሗࡀ୍ᐃࡢṇ☜ᛶࢆࡶࡗ࡚ⓗ☜࡟⛣
⾜ࡍࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋ
࡜ࡾࢃࡅࠊࡼࡾὀព῝࠸ࠊ⥅⥆ࡋࡓデ⒪ࡀᚲせ࡞៏ᛶ⑌ᝈࢆࡶࡘ⬤ᙅ㧗㱋⪅ࡢࢣ࢔⎔ቃࡀ
ኚ໬ࡍࡿ㝿࡟ࡣࠊࡇࢀࡽࡢ᝟ሗࢆ⑓㝔ࡢ་⒪ࢫࢱࢵࣇ࡜ᆅᇦࡢ་⒪࣭௓ㆤ⫋࡜ࡢ㛫࡛ࢱ࢖࣒
࣮ࣜ࠿ࡘ☜ᐇ࡟⛣⾜ࡍࡿࡇ࡜ࡀᚲせ࡛࠶ࡿࠋࡑࡋ࡚ࡑࡢࡇ࡜࡟ࡼࡗ࡚ࠊᛴᛶᮇ⑓㝔࡬ࡢධ㝔
ᮇ㛫ࢆ▷⦰ࡍࡿ࡜ྠ᫬࡟ࠊࡼࡾᝈ⪅ࢽ࣮ࢬ࡟༶ࡋࡓ἞⒪ࡀ⥅⥆ࡋ࡚⾜ࢃࢀࡿྍ⬟ᛶࢆ㧗ࡵ
ࡿࡇ࡜ࡀண ࡉࢀࡿࠋࡉࡽ࡟ࠊࡇࢀࡽࡢ᝟ሗࡀ෌ࡧ෇⁥࡟ᥦ౪ࡉࢀࡿࡇ࡜࡟ࡼࡗ࡚ࠊ㏥㝔ᚋ
ࡣࡼࡾᏳᐃࡋࡓ⒪㣴⏕ά࡟⛣⾜ࡍࡿࡢࡳ࡞ࡽࡎࠊᏳ඲࡛࠿ࡘᝈ⪅࠾ࡼࡧᝈ⪅ᐙ᪘࡟࡜ࡗ࡚
ࡼࡾᮃࡲࡋ࠸⒪㣴⏕άࢆ⥅⥆ࡍࡿࡇ࡜ࢆྍ⬟࡟ࡍࡿࡇ࡜ࡀண ࡉࢀࡿࠋ
ධ㏥㝔࡟࠾ࡅࡿࢣ࢔⛣⾜࡟㛵ࡋ࡚ࠊᅜእ࡛ࡣ 2000 ᖺ௦௨㝆ከࡃࡢ◊✲ࡀ⾜ࢃࢀࡿࡼ࠺
࡟࡞ࡗ࡚ࡁ࡚࠸ࡿࠋKriplalani ࡽ࡟ࡼࡿ࡜ࠊධ㝔᫬ᢸᙜ་࡜ᆅᇦࡢࣉࣛ࢖࣐ࣜࢣ࢔་ࡢ㛫ࡢ
┤᥋ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࡀ⾜ࢃࢀࡿࡢࡣࡈࡃᑡᩘ㸦3㸫20㸣㸧࡛࠶ࡾࠊ㏥㝔ᚋึᅇࡢእ᮶
ཷデࡲ࡛࡟㏥㝔ࢧ࣐࣮ࣜࡀᒆ࠸࡚࠸ࡿࡢࡶᑡᩘ㸦12-34㸣㸧࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࠊࡇࢀ
ࡽࡢ᝟ሗ⛣⾜ࡀ୙༑ศ࡛࠶ࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋࡲࡓࠊ୙㐺ษ࡞᝟ሗ⛣⾜࡟ࡼࡾࠊᝈ⪅‶㊊
ᗘࡢపୗࠊ๪స⏝ࡢⓎ⏕ࠊ෌ධ㝔⋡ࡀቑຍࡍࡿࡇ࡜ࡶ᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞ධ㏥
㝔᫬ࡢ᝟ሗఏ㐩࢚࣮ࣛࢆ㜵ࡄࡓࡵ࡟ࠊࢥࣥࣆ࣮ࣗࢱᢏ⾡ࢆ฼⏝ࡋࡓ㏥㝔ࢧ࣐࣮ࣜࡢᨵၿࡸࠊ
஦๓ࡢ᝟ሗඹ᭷ࡢヨࡳࡀ⾜ࢃࢀ࡚࠾ࡾࠊ࠸ࡃࡘ࠿ࡣᡂᯝࢆࡶࡓࡽࡋ࡚࠸ࡿࡶࡢࡶ࠶ࡿࡀࠊỴ
ᐃⓗ࡞ᨵၿ⟇࡟ࡣ⮳ࡗ࡚࠸࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋ
ᮏ㑥࡟࠾࠸࡚ࡣ㏥㝔ᨭ᥼࣭㏥㝔ㄪᩚ࡟㛵ࡋ࡚ࠊ㧗㱋⪅࡟࠾ࡅࡿ㏥㝔ᨭ᥼ࢶ࣮ࣝࡢ㛤Ⓨࡸࠊ
⑌ᝈูࡢᆅᇦ㐃ᦠࣃࢫ࡞࡝ࡢసᡂ࡟ࡼࡿデ⒪᝟ሗࡢ㐺ษ࡞ඹ᭷࡟㛵ࡍࡿヨࡳࡣࡇࢀࡲ࡛ᩘ
ከࡃ⾜ࢃࢀ࡚ࡁࡓࠋࡋ࠿ࡋᛴᛶᮇ⑓㝔ࡢධ㏥㝔᫬࡟ᥦ౪ࡉࢀࡿデ⒪᝟ሗ࡟㛵ࡍࡿෆᐜࡸࡑ
ࢀࡽࡀࡑࡢᚋࡢデ⒪㠃࡟୚࠼ࡿᙳ㡪࡟ࡘ࠸࡚ࡣ࡯࡜ࢇ࡝᳨ウࡀ࡞ࡉࢀ࡚࠸࡞࠸ࠋ2008 ᖺ࡟
ᘅ℩ࡽࡀ⾜ࡗࡓᛴᛶᮇᚰ➽᱾ሰ἞⒪ᚋࡢ 19 ౛ࡢデ⒪᝟ሗᥦ౪᭩ࡢㄪᰝ࡛ࡣࠊෙື⬦ᡤぢࡸ
἞⒪ෆᐜ࡟ࡘ࠸࡚ࡢグ㍕ࡣከࡃࡢሙྜ⾜ࢃࢀ࡚࠸ࡿࡶࡢࡢࠊḟᅇࡢෙື⬦㐀ᙳணᐃࡸ⚗↮
ᣦᑟ࣭ᚰ⮚ࣜࣁࣅࣜࡢ᭷↓࡞࡝௒ᚋࡢ⒪㣴࡟ᚲせ࡞᝟ሗࡀḞⴠࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞
ࡗ࡚࠸ࡿࠋࡉࡽ࡟ࠊ་⒪᝟ሗ௨ୖࡢᝈ⪅ࡢ㸿㹂㹊ࡸ௓ㆤయไ࡞࡝࡟㛵ࡍࡿ⏕ά᝟ሗࠊᝈ⪅ࡸ
ᝈ⪅ᐙ᪘ࡢ౯್ほࡸ㑅ዲࠊ௒ᚋࡢ⒪㣴యไ࡬ࡢᕼᮃࠊධ㝔୰ࡢࢣ࢔య㦂ࠊAdvance care
planning ࡢ≧ἣ࡞࡝࡟㛵ࡍࡿᐇドⓗ◊✲ࡣࡇࢀࡲ࡛࡯࡜ࢇ࡝⾜ࢃࢀ࡚࠸࡞࠸ࠋ
ࡇࢀࡽࡢඛ⾜◊✲࠿ࡽࡢ⤖ᯝࢆࡩࡲ࠼ࠊᮏ◊✲࡛ࡣࠊ࡜ࡾࢃࡅせ௓ㆤ㸰⛬ᗘ௨ୖࡢ⬤ᙅ㧗
㱋⪅ࡀᚰ୙඲ࠊ⫵⅖㸪⬻⾑⟶㞀ᐖࠊᒀ㊰ឤᰁ⑕࡞࡝ࡢᛴᛶᮇ⑌ᝈ࡟ࡼࡾձᛴᛶᮇ⑓㝔࡟ධ㝔
ࡍࡿ㝿,㔜せ࡜ᛮࢃࢀࡿデ⒪᝟ሗ࠾ࡼࡧ⏕ά࣭ࢣ࢔᝟ሗࠊ࠾ࡼࡧղ⑌ᝈࡀ㍍ᛌࡋࠊᛴᛶᮇ⑓
㝔࠿ࡽ㏥㝔ࡍࡿ㝿࡟㔜せ࡜ᛮࢃࢀࡿデ⒪᝟ሗ࠾ࡼࡧ⏕ά࣭ࢣ࢔᝟ሗ࡜ࡣఱ࠿ࠊࡉࡽ࡟ճࡇࢀ
ࡽࡢ᝟ሗࡀ㏻ᖖࡢデ⒪᝟ሗᥦ౪᭩࡟ຍࢃࡾ௜ຍⓗ࡞᝟ሗࣇ࢛࣮࣐ࢵࢺࡀసᡂࡉࢀࡿࡇ࡜࡟
ࡼࡗ࡚ࠊᨵၿࡀᮇᚅࡉࢀࡿධ㝔୰ࡢデ⒪࣭ࢣ࢔ෆᐜ࠾ࡼࡧ㏥㝔ᚋࡢデ⒪࣭ࢣ࢔ෆᐜ࡟ࡣ࡝ࡢ
ࡼ࠺࡞ࡶࡢࡀ࠶ࡿ࠿ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
◊✲ࢹࢨ࢖ࣥࡣ༙ᵓ㐀໬࢖ࣥࢱࣅ࣮ࣗ࠾ࡼࡧࣇ࢛࣮࢝ࢫ࣭ࢢ࣮ࣝࣉ࢖ࣥࢱࣅ࣮ࣗࢆ฼⏝
ࡋࡓ㉁ⓗ◊✲࡛࠶ࡿࠋ
2016 ᖺ 1 ᭶ࡼࡾࠊࢫࣀ࣮࣮࣎ࣝࢧࣥࣉࣜࣥࢢࢆ⏝࠸࡚ࠊᆅᇦࡢᅾᏯࢡࣜࢽࢵࢡ໅ົ་ᖌ
1 ྡࠊ⑓㝔໅ົෆ⛉་་ᖌ 1 ྡࠊゼၥ┳ㆤᖌ 1 ྡࠊࢣ࢔࣐ࢿࢪ࣮ࣕ1 ྡࠊᅾᏯㄪᩚ┳ㆤᖌ 1
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ྡࡢィ 5 ྡ࡟ࡼࡾಶูࡢ࢖ࣥࢱࣅ࣮ࣗࢆᐇ᪋ࠋ஦๓࡟タᐃࡋࡓ࢖ࣥࢱࣅ࣮ࣗ࢞࢖ࢻ࡟ᇶ࡙
࠸࡚ࠊࡑࢀࡒࢀ࠾ࡼࡑ 1 ᫬㛫ࡢ༙ᵓ㐀໬࢖ࣥࢱࣅ࣮ࣗࢆᐇ᪋ࡋࡓࠋ
ࡲࡓࠊࡇࢀࡽࡢ࢖ࣥࢱࣅ࣮ࣗෆᐜࢆࡶ࡜࡟ࠊࣔࢹ࣮ࣞࢱ࣮࢞࢖ࢻࢆసᡂࠊ2016 ᖺ 2 ᭶ 11
᪥࡟ᛴᛶᮇ⑓㝔࡟໅ົࡍࡿ⫋ဨ㸦་ᖌ࣭㏥㝔ㄪᩚ┳ㆤᖌ࣭ࢯ࣮ࢩ࣮࣮ࣕࣝ࣡࢝㸧ࢆᑐ㇟࡟ࢢ
࣮ࣝࣉ࢖ࣥࢱࣅ࣮ࣗࢆᐇ᪋ࠋ2 ᭶ 21 ᪥࡟ࡣࠊᆅᇦࡢࣉࣛ࢖࣐ࣜࢣ࢔ࢆᢸᙜࡍࡿከ⫋✀ࢆᑐ
㇟࡟ࢢ࣮ࣝࣉ࢖ࣥࢱࣅ࣮ࣗࢆ෌ᗘᐇ᪋ࡍࡿணᐃ࡛࠶ࡿࠋ
⤖ ᯝ
⌧ᅾಶู࢖ࣥࢱࣅ࣮ࣗ5 ྡࠊ࠾ࡼࡧᛴᛶᮇ⑓㝔࡟໅ົࡍࡿ⫋ဨ 8 ྡ࡟㛵ࡍࡿࢢ࣮ࣝࣉ࢖ࣥ
ࢱࣅ࣮ࣗ࡟㛵ࡋ࡚ࢹ࣮ࢱ཰㞟ࢆ⤊஢ࠋศᯒࡣ௒ᚋࠊᆅᇦࡢࣉࣛ࢖࣐ࣜࢣ࢔ࢆᢸᙜࡍࡿከ⫋✀
ࢆᑐ㇟࡟ࡋࡓࢢ࣮ࣝࣉ࢖ࣥࢱࣅ࣮ࣗࡀ⤊஢ᚋ࡟㡰ḟ⾜࠺ணᐃ࡛࠶ࡿࠋ
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ᨻ⟇་⒪௻⏬◊✲㒊
་⒪⤒῭᝟ሗ◊✲࣭㧗㱋⪅ࢣ࢔◊✲ᐊ㛗 ᮏ⏣ ⨾࿴Ꮚ
ᖺࠊ་⒪⤒῭᝟ሗ◊✲࣭㧗㱋⪅ࢣ࢔◊✲ᐊ࡛ࡣ▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗࢣ࢔
ᢏἲ㸸࣐ࣘࢽࢳ࣮ࣗࢻ+XPDQLWXGH࡟㛵ࡍࡿ◊✲࣭Ⓨ⾲࣭◊ಟ஦ᴗࢆᐇ᪋ࡋࡲࡋࡓࠋ◊
✲࡟ࡘ࠸࡚ࡣཌ⏕ປാ┬⛉Ꮫ◊✲㈝⿵ຓ㔠࡟ࡼࡿ㸰ࡘࡢㄢ㢟ࠊձ㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲஦ᴗ
㸦㞀ᐖ⪅ᨻ⟇⥲ྜ◊✲஦ᴗ㸦⢭⚄㞀ᐖศ㔝㸧㸧ࠕ⢭⚄㞀ᐖ⪅ࡢᆅᇦ⏕άᨭ᥼ࡢᅾࡾ᪉࡜ࢩࢫ
ࢸ࣒ᵓ⠏࡟㛵ࡍࡿ◊✲ࠖࡢศᢸ◊✲࡜ࡋ࡚ࠊࠕᆅᇦ♫఍࡛ᬽࡽࡍㄆ▱⑕㧗㱋⪅࡬ࡢໟᣓⓗ
࡞ࢣ࢔ᢏἲࡢຠᯝ࡟㛵ࡍࡿ᳨ウࠖ࠾ࡼࡧղ࢚࢖ࢬᑐ⟇◊✲஦ᴗ㸦࢚࢖ࢬᑐ⟇ᨻ⟇◊✲஦
ᴗ㸧ࠕ+,9 ឤᰁ⑕ࡢ་⒪యไࡢᩚഛ࡟㛵ࡍࡿ◊✲ࠖࡢศᢸ◊✲ࠕㄆ▱⑕ࢆྵࡴ㧗㱋 +,9
㝧ᛶ⪅ࡢ㛗ᮇ⒪㣴࡟㛵ࡍࡿㄢ㢟ᢳฟࠖࢆ⾜࡞࠸ࡲࡋࡓࠋձ࡟ࡘ࠸࡚ࡣࠊᮏᖺᗘࡣᆅ᪉㒔ᕷ
࠾ࡼࡧൢᆅ࡛⮬Ꮿ௓ㆤࢆ⾜࡞ࡗ࡚࠸ࡿᐙ᪘࡟ࢣ࢔ᢏ⾡◊ಟࢆ⾜࠸ࠊㄆ▱⑕㧗㱋⪅ࡢㄆ▱⑕
⾜ືᚰ⌮⑕≧࠾ࡼࡧ௓ㆤ⪅ࡢ௓ㆤ㈇ᢸឤࡢኚ໬࡟ࡘ࠸࡚ࡢ᳨ドࢆ⾜࡞࠸ࡲࡋࡓࠋ◊ಟᚋ
㸯࣭㸱ࣨ᭶ᚋࡢㄆ▱⑕⾜ືᚰ⌮⑕≧ࡣ᭷ព࡟ᨵၿࡀㄆࡵࡽࢀࠊࡲࡓ௓ㆤ㈇ᢸឤࡢቑᝏࡶ࠶
ࡾࡲࡏࢇ࡛ࡋࡓࠋ᮶ᖺᗘࡣᑐ㇟ࢆᨻ௧ᣦᐃ㒔ᕷ࡟ᗈࡆࡓ◊✲ࢆᐇ᪋ࡍࡿணᐃ࡛ࡍࠋղ࡟ࡘ
࠸࡚ࡣ +,9 ឤᰁ⪅ࡢవ࿨ࡀᢠ +,9 ἞⒪⸆ࡢ㐍Ṍ࡟ࡼࡾ㣕㌍ⓗ࡟ྥୖࡋࡓ୍᪉࡛ࠊ᪂ࡓ࡟
⏕ࡌࡓ +,9 ឤᰁ⪅ࡢ㧗㱋໬࡟క࠺㛗ᮇ⒪㣴ࡢሙࡢᅽಽⓗ࡞୙㊊࡟ᝈ⪅ࡣ┤㠃ࡋ࡚࠸ࡲ
ࡍࠋᮏ◊✲࡛ࡣࠊ࡜ࡾࢃࡅ⸆ᐖ࢚࢖ࢬᝈ⪅ࡢ㛗ᮇ⒪㣴ࡢሙࡢ☜ಖࡢࡓࡵ࡟ᚲせ࡜ࡉࢀ࡚࠸
ࡿㄢ㢟ࡢᢳฟ࡜ࡑࡢゎỴ⟇ࡢ᳨ウࠊ࠾ࡼࡧ⾑཭⑓ᛶ㛵⠇⑕➼ࡢ㌟యⓗၥ㢟࡟㛵ࡋ࡚ᙺ࡟❧
ࡘࠊ㉁ࡢ㧗࠸ࢣ࢔ᢏ⾡ࡢ㛤Ⓨࢆ⾜ࡗ࡚࠸ࡲࡍࠋ᪥ᮏࣉࣛ࢖࣐ࣜࢣ࢔Ꮫ఍࣭᪥ᮏ㞟୰἞⒪Ꮫ
఍࣭᪥ᮏ⢭⚄ಖ೺┳ㆤᏛ఍࣭᪥ᮏᅾᏯ་Ꮫ఍࣭᪥ᮏᚰ㌟་Ꮫ఍➼ከࡃࡢᏛ⾡ᅋయ࡛ࡢᩍ⫱
ㅮ₇ࡸࠊ኱Ꮫ་Ꮫ㒊࡛ࡢㅮ⩏ࡶ⾜࡞࠸ࡲࡋࡓࠋࡲࡓࠊᾏእ࡛ࡢ┳ㆤ࣭௓ㆤࡢᏛ఍࡟࠾ࡅࡿ
Ⓨ⾲ࡶ⾜࡞࠸ࡲࡋࡓࠋ᭦࡟ࠊ➨㸱ᅇ࡜࡞ࡿࢣ࢔࡟㛵ࡍࡿᕷẸබ㛤ㅮᗙࠕࠗࡼ࠸ࢣ࢔࡜ࡣఱ
࠿࠘ࢆ⪃࠼ࡿࠖࢆ㛤ദࠊࣇࣛࣥࢫ࠿ࡽ⪁ᖺ་Ꮫᑓ㛛་ &DQGLGD'HOPDV ඛ⏕ࢆᇶㄪㅮ₇
⪅࡜ࡋ࡚࠾㏄࠼ࡋࡲࡋࡓࠋࡉࡽ࡟ࠊᑐእⓗ࡞άື࡜ࡋ࡚ࠊ▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗ
ࢣ࢔ᢏἲ࣭࣐ࣘࢽࢳ࣮ࣗࢻࡢ◊ಟ఍ࢆᐃᮇⓗ࡟㛤ദࡋ࡚࠸ࡲࡍࠋ ᖺࡣ඲ᅜ࠿ࡽ ྡࡀ࣐ࣘࢽࢳ࣮ࣗࢻࡢ◊ಟ࡟ཧຍࡋࡲࡋࡓࠋ
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[ ་⒪⤒Ⴀ᝟ሗ◊✲ᐊ ]
Ϩ㸬ඛኳᛶ㞴⫈ඣࡢデ᩿࡜ேᕤෆ⪥἞⒪ࡢ 2015 ᖺࡢືྥ
2001 ᖺ࠿ࡽ᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡼࡗ࡚ඛኳᛶ㞴⫈ࡣ᪩ᮇⓎぢࡉࢀࡿࡼ࠺࡟࡞
ࡗࡓࠋࡑࢀ࠿ࡽ 14 ᖺࡀ㐣ࡂࡓࠋᮾி་⒪ࢭࣥࢱ࣮࡛ࡶ௵ព࡛ 6,700 ෇ࡢ᳨ᰝᩱ࡛⌧ᅾᐇ
᪋ࡉࢀ࡚࠸ࡿࠋ2007 ᖺ 4 ᭶ࡼࡾຍᡃ࡜ᯇỌ࡛㛤タࡋࡓࠕᗂᑠඣ㞴⫈࣭ゝㄒ㞀ᐖࢡࣜࢽࢵ
ࢡࠖ࡟ࡣᮾி࣭⚄ዉᕝ࣭༓ⴥ࣭ᇸ⋢ࢆ୰ᚰ࡟඲ᅜࡼࡾ㞴⫈ࢆ␲ࢃࢀࡓ᪂⏕ඣ࣭ஙᗂඣࡀ୧
ぶ࡟㐃ࢀࡽࢀ࡚ཷデࡋ࡚࠸ࡿࠋࡇࡢ 4 ࡘࡢᆅᇦࢆ Greater Tokyo ࡜࿧ࡪ࡜ேཱྀࡣ⣙ 3000
୓ே࡛࣮ࣚࣟࢵࣃࡢ୰ࡄࡽ࠸ࡢつᶍࡢᅜ࡟┦ᙜࡍࡿࠋ࢖ࣥࢱ࣮ࢿࢵࢺୖࠊࡇࡢእ᮶ࡣᑠඣ
ࡢ㞴⫈㡿ᇦ࡛࢔ࢡࢭࢫᩘࡀ࠸ࡎࢀ࡛ࡶ 2008 ᖺࡼࡾ 2015 ᖺࡢ⌧ᅾ࡟⮳ࡿࡲ࡛ࡢ 6 ᖺ㛫㐃
⥆඲ᅜ➨ 1 ఩࡜࡞ࡗ࡚࠸ࡿࠋࡑࡢࡓࡵ࢖ࣥࢱ࣮ࢿࢵࢺ࡛ぢࡘࡅ࡚㞴⫈ࡸᑠ⪥⑕ࡢᝈ⪅ࡀእ
᮶ࡢࡓࡧ࡟ཷデࡍࡿࠋ኱Ꮫ⑓㝔࡟ཷデࡋ࡚࠸࡚ࡶᮾி་⒪ࢭࣥࢱ࣮ࡲ࡛㐲࠸࡟ࡶ࠿࠿ࢃࡽ
ࡎཷデࡍࡿࡇ࡜ࡀᖺࠎቑ࠼࡚࠸ࡿࠋ
ᗂᑠඣࡢ㞴⫈ࡢ་⒪ࡣḟࡢ㡰࡛㐍ࡵࡿࠋ⏘⛉࡛ࡢձ᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢࡀᐇ᪋ࡉ
ࢀࠊḟ࠿ࡽࢃࢀࢃࢀࡢ௙஦࡜࡞ࡾࠊղ᪩ᮇ⢭ᐦ⫈ຊ᳨ᰝ࠾ࡼࡧᖹ⾮ᶵ⬟᳨ᰝࠊճ㌟య㞀ᐖ
⪅ᡭᖒ㸦⫈ぬ㞀ᐖ㸧࡜⿵⫈ჾ஺௜ពぢ᭩ࡢⓎ⾜ࠊմ㞴⫈ඣ㏻ᅬ᪋タ࠶ࡿ࠸ࡣ⫈ぬཱྀヰἲࡢ
⚾❧࣭ᅜ❧࣭බ❧ࢁ࠺Ꮫᰯ࡬⏕ᚋ 6 ࣨ᭶ࡲ࡛࡟୧⪥⿵⫈ჾ⿦⏝ୗࡢᩍ⫱ࢆ౫㢗ࡍࡿࠊյ㞴
⫈ࡀ㔜ᗘ࡛ 1 ṓ 6 ࣨ᭶㹼2 ṓࡲ࡛ࡢ㛫⫈ぬゝㄒⓎ㐩ࡀ༑ศ࡛࡞࠸ሙྜࠊேᕤෆ⪥ᇙ㎸⾡ࢆ
2 ṓ๓ᚋ࡛⾜࠺ࠋࡓࡔࡋࠊ㞴⫈ࡀ 1㹼2 ṓ࡛ึࡵ࡚Ⓨぢࡉࢀࡓ㞴⫈ඣࡣࠊ⿵⫈ୗࡢᩍ⫱ࢆ⣙
6 ࣨ᭶ほᐹࡋ࡚⿵⫈ຠᯝࡀ୙༑ศ࡛࠶ࢀࡤேᕤෆ⪥ᇙ㎸⾡ࢆ⾜࠺ࠋն⿵⫈ჾ࠾ࡼࡧேᕤෆ
⪥⿦⏝ୗࡢ㞴⫈ඣࡢᑠᏛᰯ㑅ᢥࠊධᏛᚋࡢᏛᰯᩍ⫱࡛ࡢᚰࡢࢣ࢔ࠊշ㧗➼ᩍ⫱࣭ᩍ⫱ᨭ᥼
◊✲ࠊոᑵ⫋࡬࡜ࡘ࡞ࡆ࡚࠸ࡿࠋඛኳᛶ㞴⫈ࡢཎᅉࡣࠊ㑇ఏᏊኚ␗ࡀ⣙ 50㸣ࠊ࿘⏘ᮇ㞴⫈
ࡢ࠺ࡕࢧ࢖ࢺ࣓࢞ࣟ࢘࢕ࣝࢫࡀ 5㹼10㸣ࠊඛኳወᙧࠊᰁⰍయ␗ᖖࠊ᪂⏕ඣ㔜⑕㯤⑇ࠊ௬Ṛ
࡞࡝ࡀ࠶ࡿࠋேᕤෆ⪥ᡭ⾡ࡣ 2015 ᖺࡣ 50 ౛࡟ᐇ᪋ࡋࠊ඲ᅜ࡛ࡶࢺࢵࣉࢢ࣮ࣝࣉ࡟ධࡾࠊ
2015 ᖺ 12 ᭶࡛ 250 ௳ࢆ㉺࠼ࡓࠋ㏆ᖺ㞴⫈㑇ఏᏊ᳨ᰝࢆᕼᮃࡍࡿ୧ぶࡀቑ࠼ࠊᯇỌ㐩㞝ඛ
⏕ࡀᑐᛂࡋ࡚࠸ࡿࠋ
㸯㸬 ᪩ᮇⓎぢ࣭᪩ᮇᩍ⫱ᖺ㱋࡜᪩ᮇ௓ධ㸦⿵⫈ჾ࣭ேᕤෆ⪥㸧ࡢຠᯝཬࡧ ANSD ࡟㛵ࡍ
ࡿ◊✲
ᖹᡂ 25 ᖺᗘ⌧ᅾ 5㹼7 ṓ࡟࡞ࡗࡓᑠඣ࡛ࠊึデ᫬ࠊ㞴⫈࣭ゝㄒ㞀ᐖ࡛ཷデࡋࡓ 177 ྡ
୰ࠊࢃࡎ࠿ 31㸣ࡋ࠿᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢࢆཷࡅ࡚࠸࡞࠿ࡗࡓࡇ࡜ࡀุ᫂ࡋࡓࡀࠊᖹ
ᡂ 27 ᖺᗘࡶࡑࡢഴྥࡣኚࢃࡽ࡞࠸ࠋᮾி㒔ࡢࡇࡢࢫࢡ࣮ࣜࢽࣥࢢࡢᐇ᪋⋡ࡣ 50㸣࡜ప࠸
ࡇ࡜ࡢ཯࡛ᫎ࠶ࡿࠋ᪩ᮇᖺ㱋࡛ேᕤෆ⪥ᇙ㎸⾡ࢆཷࡅࡓ㞴⫈ඣࡢゝㄒᛶ IQ ࡣ೺⫈ඣ࡜ኚ
ࢃࡽ࡞࠿ࡗࡓࠋࢃࢀࢃࢀࡀ㐃ᦠࡋ࡚࠸ࡿᐩኈぢྎ⫈ࡇ࠼࡜ࡇ࡜ࡤࡢᩍᐊࡢᬑ㏻ᑠᏛᰯ࡬ࡢ
ᑵᏛ⋡ࡣ 80㸣࡜㧗ࡃࠊࢁ࠺Ꮫᰯࡣ 15㸣⛬ᗘ࡟㐣ࡂ࡞࠸ࠋAuditory Neuropathy Spectrum
Disorder (ANSD)◊✲ࡣ AMED ࡢ◊✲㈝࡟᥇ᢥࡉࢀࠊ᫖ᖺ࡜௒ᖺᗘ࡜ 2 ᅇ⌜఍㆟ࢆ⾜ࡗ
ࡓࠋ
㸰㸬 ㍍࣭୰➼ᗘ㞴⫈
᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡼࡗ࡚㍍㹼୰➼ᗘ㞴⫈ࡀ 0㹼1 ṓ࡛᪩ᮇ࡟Ⓨぢࡉࢀࡿࡼ࠺
― 15 ―
࡟࡞ࡾࠊ᪩ᮇ⿵⫈࡟ࡼࡗ࡚ゝㄒⓎ㐩ࡢ㐜ࢀࢆண㜵࡛ࡁࡿࡼ࠺࡟࡞ࡗࡓࠋ᪩ᮇ࡟⿵⫈ჾࢆ⿦
⏝ࡋ࡚౑⏝ᮇ㛫ࡀ㛗࠸࡯࡝ゝㄒຊࡀࢃ࠿ࡗ࡚࠸ࡿࡀࠊ1 ṓ௨ෆ࡛ࡢ☜ᐃデ᩿ࡣ㞴ࡋ࠸ࡢ࡛
ࣇ࢛࣮ࣟ࢔ࢵࣉࡋ࡞ࡀࡽࡢ᳨ᰝࡀ㘽࡜࡞ࡿࠋᮾி࡛ࡣ㍍࣭୰➼ᗘ㞴⫈ඣ࡟ࡣ 13 ୓ 2000 ෇
ࡀ᥼ຓࡉࢀࡿࡼ࠺࡟࡞ࡾࠊ኱ࡁ࡞㐍Ṍࡀࡶࡓࡽࡉࢀࡓࠋ
୍᪉ࠊ㞴⫈࡟ຍ࠼࡚Ⓨ㐩㞀ᐖࢆྜేࡍࡿሙྜࡶᑡ࡞ࡃ࡞࠸ࡇ࡜ࡀุ᫂ࡋࠊࡩࡉࢃࡋ࠸⒪
⫱ඛ࡜㐃ᦠࡋ࡚㐍ࡵ࡚࠸ࡿࠋ
㸱㸬ඛኳᛶ㞴⫈ඣࡢጼໃ཯ᑕ㐠ືࡢⓎ㐩࡟㛵ࡍࡿ◊✲
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㌿᳔Ꮚ║᣺᳨ᰝ⿦⨨ࢆ⏝࠸࡚◊✲ࡋ࡚࠸ࡿࠋࡇࡢ⿦⨨ࡣ౯᱁ࡀ⣙ 1000 ୓෇࡜㧗㢠࡛ࠊ඲
ᅜ࡛ࡶ 3 ྎࡋ࠿࣮ࣝࢳࣥ࡟౑⏝ࡉࢀ࡚࠸࡞࠸ࠋ㞴⫈ඣ࡛㤳ࡢࡍࢃࡾࡸṌ⾜㛤ጞࡀ㐜ࢀࡿሙ
ྜࠊᅇ㌿᳔Ꮚ║᣺᳨ᰝࢆᐇ᪋ࡋࠊㄏⓎࡉࢀࡿ║᣺ࡀஈࡋ࠸ሙྜࡣᮎᲈᛶ࡛࠶ࡿ࡜デ᩿࡛ࡁ
ࡿࠋᑠඣ⛉࡛ࡣ⢭⚄㐠ືⓎ㐩㞀ᐖ࡜ㄗデࡉࢀࡿࡇ࡜ࡀከ࠸ࠋ๓ᗞ㢕➽㟁఩ࡶᑟධࡋࠊෆ⪥
ወᙧඣ࡛ࡶࡇࡢ཯ᛂࡀฟ⌧ࡍࡿࡇ࡜ࢆぢฟࡋࡓࠋ᮶ᖺᗘࡣ୰ᅜࡢすᏳ࠿ࡽ␃Ꮫ⏕ࡀ᮶᪥ࡍ
ࡿࠋࡇࡢၥ㢟࡟ྲྀࡾ⤌ࢇ࡛ࡶࡽ࠺ணᐃ࡛࠶ࡿࠋ2015 ᖺ࡟ᮏ◊✲ࡢᡂᯝࡣ᪥ᮏᑠඣ⪥㰯ဗႃ
⛉Ꮫ఍ㄅ࡟ᥖ㍕ࡉࢀࡓࠋ
㸲㸬ඛኳᛶ┣ࢁ࠺ඣࡢᖹ⾮ࡢⓎ㐩◊✲࠾ࡼࡧᡂேࡢ┣ࢁ࠺⪅ࡢேᕤෆ⪥◊✲
㉸పయ㔜ฟ⏕ඣ࠾ࡼࡧඛኳᛶ㢼⑈⑕ೃ⩌࡟ࡣ┣ࢁ࠺ඣࡢ㢖ᗘࡀ㧗࠸ࠋどぬ࡜⫈ぬ࣭ᖹ⾮
ぬࡢ஧㔜㞀ᐖ࡛ࡣ≉ู࡞ᩍ⫱ࡀᚲせ࡛ࠊゐぬࡸ᣺ືឤぬࠊႥぬࠊ࿡ぬࢆ⏕࠿ࡋࡓᩍ⫱ࡢᕤ
ኵࡀᚲせ࡛࠶ࡿࠋࢃࢀࢃࢀࡢ㉸☢ṍᆺࡢ㦵ᑟ⣲Ꮚ࡟ࡼࡿ่⃭ࡀ᭷ຠ࡛࠶ࡿࡇ࡜ࢆぢฟࡋࠊ
᪥ᖖⓗ࡟㡢ᴦࡢయ㦂ࡢࡓࡵ࡟㈚ࡋฟࡋ࡚౑⏝ࡋ࡚ࡶࡽࡗ࡚࠸ࡿࠋ┣ࢁ࠺ඣ࡛ࡣ㤳ࡢࡍࢃࡾ
ࡸṌ⾜㛤ጞࡀࡑࢀࡒࢀ༢⊂㞀ᐖࡼࡾࡶࡉࡽ࡟㐜ࢀࡿࡇ࡜ࢆぢฟࡋࠊゐぬࢆ㏻ࡋࡓࣜࣁࣅࣜ
ࡢ᪉ἲࢆ◊✲୰࡛࠶ࡿࠋᡂேࡢ┣ࢁ࠺⪅ࡢேᕤෆ⪥ᇙ㎸⾡ࢆ᪤࡟ 7 ྡ࡟ᐇ᪋ࡋࠊQOL ࡢ
ᨵၿࡢ◊✲ࢆ㛤ጞࡋࡓࠋᑠඣ࡟ࡣ࢘࢜ࣝࣇ⑕ೃ⩌ࡢ 1 ౛࡟ᐇ᪋ࡋࡓࠋேᕤෆ⪥࡟ࡼࡗ࡚⫈
ぬࢆྲྀࡾᡠࡍ࡜ࠊゐ㏻ヂࢆ௓ࡉࡎ࡟఍ヰࡀྍ⬟࡜࡞ࡾࠊQOL ࡢᅇ᚟ࡣⴭࡋ࠸ࠋ
㸳㸬ேᕤෆ⪥ᇙ㎸⾡ࡢ EABR ◊✲
⾡୰࡟ࠊேᕤෆ⪥㟁ᴟࢆᤄධᚋࡢ EABR グ㘓ࢆࡇࡢ 2 ᖺ㛫⾜ࡗ࡚࠸ࡿࠋࡑࡢᡂᯝࡣ 2013
ᖺࡢ Polizter Ꮫ఍࡛Ꮫ఍㈹࡟㑅ࡤࢀࡓࠋ2015 ᖺ࡟ Acta Oto-Laryngologica ࡟ห⾜ࡉࢀࡓࠋ
ϩ㸬ඛኳᛶᑠ⪥⑕࣭እ⪥㐨㛢㙐⑕ࡢᡭ⾡ࡢ㛤Ⓨ࡜Ẽᑟ⿵⫈ჾ⿦⏝ࣉࣟࢪ࢙ࢡࢺࠊ㑇ఏ
Ꮚゎᯒࣉࣟࢪ࢙ࢡࢺ
㸯㸬⪥⛉࣭ᙧᡂእ⛉ྜྠᡭ⾡
ᑠ⪥⑕࣭እ⪥㐨㛢㙐ࡣ㑇ఏᏊኚ␗࡟ࡼࡿࡶࡢࡣᑡ࡞ࡃࠊ኱༙ࡀ✺↛ኚ␗࡟ࡼࡿࡶࡢ࡜⪃
࠼ࡽࢀ࡚࠸ࡿࡀࠊࡇࢀࡲ࡛ࡢ◊✲ࡣᑡ࡞࠸ࠋTreacher Collins ⑕ೃ⩌ࡣඃᛶ㑇ఏࡶ࠶ࡿࡀ
ከࡃࡣ✺↛ኚ␗࡟ࡼࡗ࡚⏕ࡲࢀ୧ഃᑠ⪥⑕࣭እ⪥㐨ወᙧࢆ࿊ࡍࡿࠋ∦ഃ࡜୧ഃࡢሙྜࡀ࠶
― 16 ―
ࡿࠋ∦ഃࡢሙྜࡣ཯ᑐࡣṇᖖ࡞ࡓࡵ∦ഃࡢ⪥௓ᙧᡂ⾡࡜እ⪥㐨ᙧᡂ⾡ࢆ⾜࠺ࠋ୧ഃࡢሙྜ
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1 ྎࢆ⿦⏝ࡍࡿࠋᑠᏛᰯධᏛᖺ㱋࡟࡞ࡗ࡚୧⪥࡟㦵ᑟ⿵⫈ჾࢆ౑⏝ࡉࡏࡿࠋࡇࢀࡲ࡛୧⪥
㦵ᑟ⿵⫈ࡢ᪉ྥឤࡸ㡢※ᐃ఩ࡣᡂ❧ࡋ࡞࠸ࡶࡢ࡜ࡉࢀ࡚ࡁࡓࡀࠊࢃࢀࢃࢀࡢ◊✲࡛ࡣᡂ❧
ࡍࡿࡇ࡜ࢆぢฟࡋࠊᑵᏛᚋࡢ୧⪥㦵ᑟ⿵⫈ჾࡢ⿦⏝ࢆ✚ᴟⓗ࡟㐍ࡵ࡚࠸ࡿࠋࡇࢀ࡟㛵ࡍࡿ
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ி་⒪ࢭࣥࢱ࣮࡛ᡭ⾡ぢᏛࢆࡋ࡚ࡶࡽࡗࡓࠋ᮶ᖺᗘࡶ෌᮶᪥ࡍࡿணᐃ࡛࠶ࡿࠋ∦ഃᑠ⪥⑕
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✲⪅࡜ࡋ࡚ཧຍࡋࠊ᫬㛫ᕪࡸ㡢ᅽᕪࡶᡂ❧ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋᝈ⪅ࡶ⿵⫈ჾ⿦⏝ࢆ
႐ࢇ࡛࠸ࡿࠋୡ⏺࡛ࡶᜍࡽࡃึࡵ࡚ࡢྲྀࡾ⤌ࡳ࡛ࠊ2015 ᖺࡢࢧࣥࣇࣛࣥࢩࢫࢥ࡛㛤ദࡉࢀ
ࡓࢥࣞࢠ࣒࢘ࡢ఍࡛Ⓨ⾲ࡋࡓࠋ2016 ᖺ࡟ㄽᩥࡀ ACTA ࡟ᥖ㍕ࡉࢀࡿணᐃ࡛࠶ࡿࠋ
㸰㸬㉸☢ṍᆺ㦵ᑟ⿵⫈ჾ㛤Ⓨ◊✲
ᚑ᮶ࡢ㟁☢ᘧ㦵ᑟ⿵⫈ࡣ㧗㡢ᇦࡢᛶ⬟ࡀ୙༑ศ࡛࠶ࡿࠋ㏆ᖺ㛤Ⓨࡉࢀࡓ㉸☢ṍᆺ㦵ᑟ➃
Ꮚࡣ 30,000Hz ࡲ࡛ࡢ㦵ᑟ่⃭ࡀྍ⬟࡛࠶ࡿࠋࡇࢀࢆ୧⪥㦵ᑟ⿵⫈ჾࡢࣉࣟࢺࢱ࢖ࣉ࡜ࡋ
࡚㛤Ⓨࡋࠊ≉࡟㡢ᴦࡢࡓࡵ࡟⏝࠸ࡿࡇ࡜ࢆ┠ⓗ࡟㛤ጞࡋࡓࠋᚑ᮶ࡢ㟁☢ᘧࡣప㡢㹼୰㡢ᇦࠊ
㉸☢ṍᘧࡣ୰㡢ᇦ㹼㧗㡢ᇦࡣࡇࢀࡲ࡛ࡢ࡝ࡢࢹࣂ࢖ࢫࡼࡾࡶඃࢀ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
2014 ᖺᗘࡣࢹࣂ࢖ࢫࡢᑠᆺ໬࡟ᡂຌࡋࠊࡑࡢ㧗࠸㡢㉁ࡀᝈ⪅ࡼࡾ႐ࡤࢀ࡚࠸ࡿࠋඹྠ㛤Ⓨ
ࡢࣇ࢙ࣞ࢖࡜ࢹ࢕࣮ࢩ࣮ࢩ࣮♫࡟ࡼࡿ࡜ࠊKAGA ࣔࢹࣝ࡜࠸࠺ྡ⛠࡛ୡ⏺㈍኎ࢆィ⏬ࡋ࡚
࠸ࡿࠋࣁ࣮ࣂ࣮ࢻࡢ᪂ᢏ⾡㛤Ⓨࡢࣞࣅ࣮ࣗ࡟ࡶᥖ㍕ࡉࢀࡓࠋࡇࢀ࡟ࡘ࠸࡚ࡶ᪉ྥឤ◊✲ࡢ
ணᐃ࡛࠶ࡿࠋ
㸱㸬Treacher Collins ⑕ೃ⩌ࡢ◊✲
୧ഃᑠ⪥⑕◊✲࡟ྲྀࡾ⤌ࢇ࡛ࡁࡓࡀࠊ300 ࢆ㉺࠼ࡿ㞴἞⑌ᝈࣜࢫࢺࡢ୰࡟ධࡗ࡚࠸࡞࠸
ࡇ࡜࡟Ẽࡀࡘࡁࠊ௒ᚋ⊂❧ࡋࡓࢸ࣮࣐࡛◊✲ࢆ㐍ࡵࡿィ⏬࡛࠶ࡿࠋ
Ϫ㸬୰ᯡ⫈ぬ◊✲
㸯㸬85 ṓ௨ୖࡢ㉸㧗㱋⪅ࡢ㞴⫈◊✲
1960 ᖺࡢ Kirikae ➼ࡢሗ࿌౫㢗ࠊຍ㱋࡟క࠺⪁ேᛶ㞴⫈ࡣᮎᲈ࡜୰ᯡࡢ㞀ᐖࡢྜࢃࡉ
ࡗࡓࡶࡢ࡛࠶ࡿ࡜ࡉࢀ࡚ࡁࡓࠋࡋ࠿ࡋࢃࢀࢃࢀࡢ◊✲࡛ࡣ㧗㱋⪅࡛࠶ࡗ࡚ࡶᮎᲈᛶ㞀ᐖ࡛
࠶ࡗ࡚୰ᯡᛶ㞀ᐖ࡛ࡣ࡞࠸ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ⣧㡢⫈ຊ᳨ᰝ࡛㜈್ࡀୖ᪼ࡋࠊㄒ㡢᫂
░ᗘ᳨ᰝ࡟ࡼࡿ༢㡢ࡢ⫈ࡁྲྀࡾࡢṇ⟅⋡ࡀ 50%௨ୗࡢ㉸㧗㱋⪅࡛࠶ࡗ࡚ࡶࠊᩥࣞ࣋ࣝࡢㄆ
― 17 ―
▱᳨ᰝ࡛ࡣ 90%௨ୖࡢṇ⟅⋡ࢆ♧ࡋࠊᮎᲈࡢෆ⪥ᛶ㞴⫈࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ80㹼
90 ṓ௦㸦Octogenarian㸧ࡢ㧗㱋⪅ࡢேᕤෆ⪥ᇙ㎸ᡭ⾡ࡢᡂᯝࡀⰋࡃࠊᚑ᮶ࡢ⪁ேᛶ㞴⫈ࡢ
࢖࣓࣮ࢪࢆࡍࡗ࠿ࡾኚ࠼ࠊ㧗㱋⪅ࡢேᕤෆ⪥ᇙ㎸⾡ࡣ Ageless ࡢ᫬௦࡜࡞ࡗ࡚࠸ࡿࠋ
㸰㸬Auditory Neuropathy (Auditory Nerve Disease)㸦AN㸧
1996 ᖺ࡟ Kaga ➼࡜ Starr ➼ࡀูࠎ࡟ሗ࿌ࡋࡓࡑࢀࡲ࡛▱ࡽࢀ࡚࠸࡞࠿ࡗࡓ᪂ࡋ࠸⫈
ぬ㞀ᐖ࡛ࠊ⫈ຊࡣⰋዲ࡞ࡢ࡟ࡶ࠿࠿ࢃࡽࡎࠊゝⴥࡢ⪺ࡁྲྀࡾࡀⴭࡋࡃᝏࡃࠊෆ᭷ẟ⣽⬊࡜
⼗∵⚄⤒ࡢ㛫ࡢࢩࢼࣉࢫࣞ࣋ࣝࡢ㞀ᐖࡀ␲ࢃࢀ࡚࠸ࡿࠋࢃࢀࢃࢀࡢࢡࣜࢽࢵࢡ࡟ࡣࡇࡢ⛥
࡞ඛኳᛶ࡜ᚋኳᛶࡢ⑌ᝈ⑕౛ࡀ඲ᅜྛᆅࡼࡾ⤂௓ࡉࢀ࡚ࡁ࡚࠸ࡿࠋ୰ᅜ࠿ࡽࡶᝈ⪅ࡀ⤂௓
ࡉࢀࡓࠋඛኳᛶࡢ AN ࡶ࠶ࡾ㛗ᮇⓎ㐩◊✲ࢆࡋ࡚࠸ࡿࠋ⫈ぬᶵ⬟ࡢ◊✲ࡢࡳ࡞ࡽࡎ㑇ఏᏊ
◊✲ࡶ⾜ࡗ࡚࠾ࡾࠊ OTOF 㑇ఏᏊ␗ᖖ࡜ OPA1 㑇ఏᏊ␗ᖖࡀぢฟࡉࢀ࡚࠸ࡿࠋඛኳᛶ
Auditory Neuropathy Spectrum Disorders (ANSD)ࡀ㉸పయ㔜ฟ⏕ඣ࡟ከ࠸ࡇ࡜ࢆぢฟ
ࡋࠊ࠿ࡘᵝࠎ࡞ࢱ࢖ࣉࡢ࠶ࡿࡇ࡜ࢆࡶࢃ࠿ࡗࡓࠋࡍ࡞ࢃࡕ DPOAE ࡜ ABR ࡀṇᖖ໬ࡍࡿ
ࢱ࢖ࣉࠊDPOAE ࡶ ABR ࡶᾘኻࡍࡿࢱ࢖ࣉࠊDPOAE㸦+㸧࡜ ABR㸦㸫㸧ࡀᣢ⥆ࡍࡿሙྜࠊ
┿ᛶ AN ࢱ࢖ࣉ࡜⫈ぬ㞀ᐖࢆḞࡃ Pseudo Type ࡟ศ࠿ࢀࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋANSD ◊✲
ࡣཌ⏕ປാ⛉Ꮫ◊✲㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲஦ᴗࡢឤぬჾ㞀ᐖศ㔝࡛ 2014 ᖺ࡟᥇ᢥࡉࢀࡓࠋ
ᡂே࡛ࡣ ᗘឤཷᛶ AN ࡢ 1 ౛ࢆⓎぢࡋࡓࠋ⫈ぬⓗ⌮ゎࡶⴭࡋࡃᝏ࠸ሙྜࠊேᕤෆ⪥ᇙ㎸
⾡ࡣ 3 ౛⾜࠸ࠊⰋ࠸⤖ᯝ࡛࠶ࡿࠋEABR ࡶⰋዲ࡛࠶ࡿࠋࡇࡢศ㢮ࡣ ANL ㄅ࡟ࣞࣅ࣮ࣗ࡜
ࡋ࡚ 2016 ᖺ 1 ᭶࡟ᥖ㍕ࡉࢀࡿணᐃ࡛ࠊୡ⏺ⓗ࡞ΰ஘࡟⤊Ṇ➢ࢆᡴࡘࡇ࡜࡟ࡘ࡞ࡀࡿࡇ࡜
ࢆᮇᚅࡋ࡚࠸ࡿࠋ
㸱㸬⫈ぬ⌮ゎࡢ㞀ᐖ࡜⓶㉁⫏
ᕥ༙⌫ഃ㢌㢌㡬ⴥࡢᦆയ࡟ࡼࡿ⫈ぬⓗ⌮ゎࡢ㞀ᐖ⑕౛ࢆ 2 ౛ࠊእ᮶࡛ゝㄒカ⦎ࢆ⾜࠸⬻
ࡢྍረᛶࢆほᐹࡋ࡚࠸ࡿࠋ኱⬻࡛ࣞ࣋ࣝ୧ഃࡢ⫈ᨺ⥺ࡀᦆയࡉࢀࡿ࡜ࠊ㡢ࡣ⪺ࡇ࠼ࡿࡀゝ
ⴥࡶ♫఍㡢ࡶ㡢ᴦࡶㄆ▱࡛ࡁ࡞ࡃ࡞ࡿࠋࡇࡢ≧ែࡣ⓶㉁⫏ࡸ⫈ぬኻㄆ࡜࠸࠺ࠋឤぬᛶኻ㡢
ᴦ⑕ࡣᕥྑࡢ࠸ࡎࢀࡢ∦ഃᛶࡢ኱⬻༙⌫㞀ᐖ࡛ࡶ⏕ࡌࡿࠋࡇࡢ⑕≧ࢆ࿊ࡍࡿ⬻⾑⟶㞀ᐖ౛
ࡣࡲࢀ࡛࠶ࡿࡀࠊ௚⑓㝔࠿ࡽ⤂௓ࡉࢀ࡚ཷデࡋ࡚࠸ࡿࠋࢃࢀࢃࢀࡢ㛤Ⓨࡋࡓࢸࢫࢺ࣭ࣂࢵ
ࢸ࣮࡛ࣜㄪ࡭ࠊࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ᪉ἲࡶᕤኵࡋ࡚࠸ࡿࠋ㡢ࡀ඲ࡃ⪺ࡇ࠼࡞࠸᏶඲⫏ࡢ⓶
㉁⫏⑕౛ࡢᏑᅾ࡛࠶ࡿࠋࡇࡢ⑕౛ࡣ⬻ᖿࣞ࣋ࣝࡀṇᖖ࡛ࡶ⫈ぬ཯ᛂ⾜ືࡀ⏕ࡌ࡞࠸࡜࠸࠺
㔜せ࡞♧၀ࢆ୚࠼࡚࠸ࡿṔྐⓗ࡞⑕౛࡛࠶ࡿࡓࡵࠊ2015 ᖺࡢ ACTA Otolaryngologica ࡟
ᥖ㍕ࡉࢀࡓࠋࡇࡢㄽᩥࢆㄞࢇࡔ࢝ࢼࢲࡢ◊✲⪅࠿ࡽࠊ᮶᪥ࡋ᳨࡚ᰝࢆࡋࡓ࠸࡜ࡢᡭ⣬ࡀᒆ
࠸ࡓࠋ
㸦ᩥ㈐㸸ຍᡃྩᏕ㸧
― 18 ―
ࠝ་⒪⤒Ⴀ᝟ሗ◊✲ᐊࠞ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍࣭Ꮫ⾡ㅮ₇఍ 2015.5.23 ༓௦⏣༊
CORLAS Meeting 2015
2015.8.25
San Francisco
― 19 ―
ࠝ་⒪⤒Ⴀ᝟ሗ◊✲ᐊࠞ
ඹྠ㏻ಙ㓄ಙグ஦ 㸦ୗグࡣࡑࡢ୍㒊㸧
ᆅ᪉⣬࡬ࡢᥖ㍕ከᩘ
㸦౛㸸⛅⏣᪂⪺ࠊ⚟ᓥẸሗࠊୗ㔝᪂⪺ࠊᇸ⋢᪂⪺ࠊ⚄ᡞ᪂⪺ࠊ᪥ᮏᾏ᪂⪺ࠊᚨᓥ᪂⪺ࠊ⌰⌫᪂⪺➼㸧
― 20 ―
ᨻ⟇་⒪௻⏬◊✲㒊 ᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺᢏ⾡ᛂ⏝◊✲ᐊ㛗 ᩧ⸨ ྐ㑻
ᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺᢏ⾡ᛂ⏝◊✲ᐊ࡛ࡣࠊᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺࢆ౑࠺ᡭ⾡ࡀ௒ᚋⓎᒎࡍࡿࡇ
࡜ࢆぢᤣ࠼ࠊື≀ࢆ౑ࡗࡓᡭ⾡ࡢࢺ࣮ࣞࢽࣥࢢࢭࣥࢱ࣮ࢆᖹᡂ ᖺ ᭶ ᪥࠿ࡽ✌ാࡉ
ࡏ࡚࠸ࡲࡍࠋᙜึࡣࢲࣦ࢕ࣥࢳ 66L ࡀタ⨨ࡉࢀࡲࡋࡓࡀࠊᖹᡂ ᖺ ᭶࠿ࡽࡣ 6L ༢⊂ࡢ
◊ಟ࡜࡞ࡗ࡚࠸ࡲࡍࠋࡑࢀ௨እ࡟ࡣ║⛉ᡭ⾡ࡢಟ⦎⏝㢧ᚤ㙾ࠊෆど㙾እ⛉ᡭ⾡ࢩ࣑࣮ࣗࣞࢱ
࣮ࠊᾘ໬ჾෆど㙾᳨ᰝࢩ࣑࣮ࣗࣞࢱ࣮ࡀ⨨࠿ࢀ࡚࠾ࡾࠊከ᪉㠃ࡢᡭ⾡ᡭᢏࡢྥୖࢆᅗࡿࡇ࡜
ࡀ࡛ࡁࡿࡼ࠺࡟࡞ࡗ࡚࠸ࡲࡍࠋ௒ᚋࡉࡽ࡟ෆ⏝ࢆ඘ᐇࡉࡏࠊ᪂ࡋ࠸ᡭ⾡ᡭᢏࡢ㛤Ⓨࡸᕤኵ࡟
ࡘ࡞ࡀࢀࡤ࡜⪃࠼࡚࠸ࡲࡍࠋ
ᖹᡂ ᖺࡢ㛤タ௨᮶ࠊྛ⛉ࡢ౑⏝≧ἣࡣ⾲ ࡸᅗ㸯ࡢࡼ࠺࡟࡞ࡗ࡚࠸ࡲࡍࠋࡲࡓ౑⏝ࡉ
ࢀࡓ㇜ࡢ㢌ᩘࡣ⾲ ࡟♧ࡍ㏻ࡾ࡛ࡍࠋ⌧᫬Ⅼ࡛ࡣࣟ࣎ࢵࢺᨭ᥼ᡭ⾡ࡢಖ㝤㐺ᛂࡀἪᒀჾ⛉
ࡔࡅ࡞ࡢ࡛Ἢᒀჾ⛉ࡢ౑⏝ࡀ┠❧ࡗ࡚࠸ࡲࡍࠋࣟ࣎ࢵࢺࡢᅜෆ౑⏝ྎᩘࡣࡲࡔቑຍࡋ࡚࠸
ࡿ࡟ࡶ㛵ࢃࡽࡎ㛤タᙜึ࡟ẚ࡭࡚✌ാ௳ᩘࡀῶᑡࡋ࡚࠸ࡿࡢࡣࠊ㒔ෆ࡟࣓࣮࣮࢝ࡀ᪂ࡋࡃ
ࢺ࣮ࣞࢽࣥࢢࢭࣥࢱ࣮ࢆタࡅࡓࡓࡵ࡛ࡍࠋ
௒ᚋᙜ◊✲ᐊ࡛ࡣࣟ࣎ࢵࢺࡢࢺ࣮ࣞࢽࣥࢢ࡟࡜࡝ࡲࡽࡎࠊ⭡⭍㙾ࡢࢺ࣮ࣞࢽࣥࢢ࡟ࡶᗈ
ࡃ౑⏝ࡉࢀࡿࡼ࠺࡟㐍ࡵ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡲࡍࠋࡲࡓἪᒀჾ⛉㡿ᇦ௨እ࡛ࡶಖ㝤㐺ᛂ
ࡀྔࡗࡓሙྜ࡟ࡣ㟂せࡣࡲࡓቑ࠼ࡿ࡜ᛮࢃࢀࡲࡍࠋ
⾲ ࢺ࣮ࣞࢽࣥࢢࢭࣥࢱ࣮✌ാᐇ⦼௳ᩘ
ᾘ໬ჾ⛉ Ἢᒀჾ⛉
፬ே⛉
⭡⭍㙾◊
ಟ
ィ
ᖹᡂ ᖺᗘ ᭶࠿ࡽ㸧
ᖹᡂ ᖺᗘ
ᖹᡂ ᖺᗘ
ᖹᡂ ᖺᗘ ᭶ࡲ࡛㸧
⾲ ㇜㢌ᩘ
㢌ᩘ
ᖹᡂ ᖺᗘ ᭶࠿ࡽ㸧
ᖹᡂ ᖺᗘ
ᖹᡂ ᖺᗘ
ᖹᡂ ᖺᗘ ᭶ࡲ࡛㸧
― 21 ―
― 22 ―
ᨻ⟇་⒪௻⏬◊✲㒊 ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ㛗 ᵻᒣ ᖾᙪ
㸯㸬ࡣࡌࡵ࡟
ᙜᐊ࡛ࡣࠊ2010 ᖺ㸦ᖹᡂ 22 ᖺ㸧௨㝆ࠊ⸆஦ᢎㄆࢆ┠ⓗ࡜ࡍࡿ἞㦂࡟㝈ࡽࡎࠊ࢚ࣅࢹࣥ
ࢫ๰ฟࢆ┠ⓗ࡜ࡋࡓ⮫ᗋ◊✲ࡢ CRC ཬࡧ஦ົᒁᨭ᥼ࢆ⾜ࡗ࡚࠸ࡿࡀࠊᮏᖺࡣᙜ㝔࡟࠾ࡅ
ࡿ⮫ᗋ◊✲඲యࡢရ㉁ࢆ☜ಖࡍ࡭ࡃࠊ⮫ᗋ◊✲ᨭ᥼ࢭࣥࢱ࣮タ⨨࡟ྥࡅ‽ഛࢆ㐍ࡵ࡚ࡁࡓࠋ
ࡲࡓࠊྡྂᒇ་⒪ࢭࣥࢱ࣮࡟࠾ࡅࡿ⮫ᗋ◊✲ရ㉁☜ಖయไᩚഛ஦ᴗࡢᰕ࡛࠶ࡿ“ࣔࢽࢱࣜࣥ
ࢢࣁࣈࢩࢫࢸ࣒”࡟㛵ࡋ࡚ࡶ 2012 ᖺ㸦ᖹᡂ 24 ᖺ㸧௨㝆ཧ⏬ࡋ࡚࠾ࡾࠊICH-GCP ‽ᣐࡢ◊
✲⪅୺ᑟࡢᅜ㝿ඹྠ⮫ᗋヨ㦂ࠊ་ᖌ୺ᑟ἞㦂࡬ࡢࣔࢽࢱࣜࣥࢢ࡟ᐤ୚ࡋ࡚࠸ࡿࡀࠊᮏᖺࡣ
ࡉࡽ࡟ J-GCP ᑐᛂࡢ་ᖌ୺ᑟ἞㦂࡟ࡘ࠸࡚ࠊ᪂ࡓ࡟ 2 ㄢ㢟ࡢࣔࢽࢱࣜࣥࢢࢆ㛤ጞࡋ࡚࠸
ࡿࠋ
ࡇࡢࡼ࠺࡟ᡃࠎࡢάືࡣࠊ᪤࡟἞㦂࡟≉໬ࡍࡿࡇ࡜࡞ࡃࠊᖺࠎᴗົࢆᣑ඘ࡋ࡚࠾ࡾࠊᮏ
✏࡛ࡣࠊ2015 ᖺ㸦ᖹᡂ 27 ᖺ㸧࡟࠾ࡅࡿᙜᐊࡢ἞㦂ཬࡧ⮫ᗋ◊✲ࡢᐇ⦼࡟㛵ࡋ࡚ᴫㄝࡍࡿࠋ
㸰㸬἞㦂ࡢᐇ⦼
2015 ᖺ㸦ᖹᡂ 27 ᖺ㸧࡟࠾ࡅࡿᙜ㝔ࡢ἞㦂࡟ࡘ࠸࡚ࡣࠊ2013 ᖺ㸦ᖹᡂ 25 ᖺ㸧࡟ᐇ᪋ࡋ
ࡓ〇⸆௻ᴗ࡜ᙜᐊ࡜ࡢ┦஫ぢᏛ఍ࡢᡂᯝࡶ࠶ࡾࠊ〇⸆௻ᴗ࡟ࡼࡿ᪂つ἞㦂ࡢ౫㢗ࡣᖺࠎቑ
ຍࡋ࡚࠾ࡾࠊࢥࣥࢫࢱࣥࢺ࡟ 20 ㄢ㢟㏆ࡃࡢ἞㦂ࢆཷク࡛ࡁࡿࡼ࠺࡟࡞ࡗ࡚࠸ࡿࠋࡲࡓࠊ
2014 ᖺ㸦ᖹᡂ 26 ᖺ㸧࠿ࡽ H7N9 ࢖ࣥࣇ࢚ࣝࣥࢨ࣡ࢡࢳࣥࡢ First in Human㸦FIH㸧ࡢ
་ᖌ୺ᑟ἞㦂ࢆ㛤ጞࡋ࡚࠸ࡿࠋᙜ㝔࡟࠾࠸࡚ FIH ࡢ἞㦂ࡣึࡢヨࡳ࡛࠶ࡗࡓࡶࡢࡢࠊᙜᐊ
ࡢᵻᒣᖾᙪᐊ㛗ࡢ㈐௵་ᖌࡢୗࠊᙜᐊࢫࢱࢵࣇ඲ဨࡀ୍୸࡜࡞ࡾࠊデ⒪㒊ࠊ┳ㆤ㒊ࠊ⸆๣
㒊ࠊ⮫ᗋ᳨ᰝ⛉ࠊ஦ົ㒊➼ࡢ㛵ಀ㒊㛛ࡢከ኱࡞ࡿ༠ຊࡶ࠶ࡾࠊᮏᖺ࡟↓஦⤊஢ࡍࡿࡇ࡜ࡀ
࡛ࡁࡓࠋࡇࡢ⤒㦂ࢆ㏻ࡋ࡚ࠊ㞴ᗘࡢ㧗࠸ FIH ࡢ་ᖌ୺ᑟࡢ἞㦂࡟ᑐࡋ࡚ࡶࠊᙜᐊࡣ༑ศ࡟
ᑐᛂ࡛ࡁࡿࡇ࡜ࢆ⿬࡙ࡅࡿࡇ࡜ࡀ࡛ࡁࠊࢫࢱࢵࣇ඲ဨ኱ࡁ࡞⮬ಙ࡜࡞ࡗ࡚࠸ࡿࠋ௒ᚋࠊከ
✀ከᵝࡢ἞㦂ࡢᐇ⦼ࢆ✚ࡴࡇ࡜࡟ࡼࡾࠊࡉࡽ࡟ᖜᗈ࠸἞㦂ࡢཷクࡀྍ⬟࡟࡞ࡿࡶࡢ࡜ᮇᚅ
ࡋ࡚࠸ࡿࠋ
㸱㸬⮫ᗋ◊✲ࡢᐇ⦼
ᮏᖺ࡟࠾࠸࡚ࡶࠊᅜ❧⑓㝔ᶵᵓࡢࢫࢣ࣮࣓ࣝࣜࢵࢺࢆά࠿ࡋࡓࠕEBM ᥎㐍ࡢࡓࡵࡢ኱
つᶍ⮫ᗋ◊✲㸦௨ୗࠊ
ࠕEBM ◊✲ࠖ㸧ࠖ࡟㛵ࡋ࡚ᨭ᥼ࢆ⾜ࡗࡓࠋࡉࡽ࡟ࠊඛ㏙ࡢ࡜࠾ࡾ⮫ᗋ
◊✲ᨭ᥼ࢭࣥࢱ࣮タ⨨࡟ྥࡅ‽ഛࢆ㐍ࡵࡿ࡭ࡃࠊ2015 ᖺ 11 ᭶ 26 ᪥࡟ྠࢭࣥࢱ࣮タ⨨ WG
ࢆ❧ࡕୖࡆࠊྠᖺ 12 ᭶ 9 ᪥ࡢ WG ࡟࠾࠸࡚ࠊ⮫ᗋ◊✲ᨭ᥼ࢭࣥࢱ࣮ࡢタ⨨ࡀᢎㄆࡉࢀࡓࠋ
ᙜࢭࣥࢱ࣮ࡣࠊᙜ㝔࡟࠾ࡅࡿ⮫ᗋ◊✲඲యࡢရ㉁ࢆ☜ಖࡍࡿࡇ࡜ࢆ┠ⓗ࡟タ⨨ࡉࢀࡿࡶࡢ
࡛࠶ࡾࠊ2016 ᖺ 3 ᭶࡟ᴗົࢆ㛤ጞࡍࡿࡇ࡜࡟࡞ࡗ࡚࠸ࡿࠋᙜᐊ࠿ࡽࡶேᮦ࡜ࣀ࢘ࣁ࢘ࢆ
ᥦ౪ࡍࡿࡇ࡜࡟࡞ࡗ࡚࠸ࡿࠋ
㸲㸬ࣔࢽࢱࣜࣥࢢࣁࣈࢩࢫࢸ࣒࡟ࡼࡿάື
ᙜᐊࡣࠊ2013 ᖺࡼࡾྡྂᒇ་⒪ࢭࣥࢱ࣮࡟࠾ࡅࡿ⮫ᗋ◊✲୰᰾⑓㝔஦ᴗ㸦⌧㸸⮫ᗋ◊✲
― 23 ―
ရ㉁☜ಖయไᩚഛ஦ᴗ㸧ࡢࣔࢽࢱࣜࣥࢢࣁࣈࢩࢫࢸ࣒࡟ཧ⏬ࡋ࡚࠸ࡿࠋ๓ᖺࡼࡾࠊICH-GCP
࡟ᑐᛂࡋࡓࠕ➨୍෌Ⓨᑠඣᛴᛶࣜࣥࣃᛶⓑ⾑⑓ᶆ‽ࣜࢫࢡ⩌࡟ᑐࡍࡿ➨Ϫ┦ᅜ㝿ඹྠ⮫ᗋ
ヨ㦂ࠖ࠾ࡼࡧ GCP ┬௧࡟ᑐᛂࡍࡿࠕ㭜༸ᇵ㣴୙ά໬඲⢏Ꮚ㫽࢖ࣥࣇ࢚ࣝࣥࢨ A㸦H7N9)
࣡ࢡࢳࣥࡢච␿ཎᛶ࠾ࡼࡧᏳ඲ᛶࡢ᳨ウ㸦➨ϩ┦་ᖌ୺ᑟ἞㦂㸧ࠖࡢࣔࢽࢱࣜࣥࢢࢆ⾜ࡗ࡚
࠾ࡾࠊᮏ᱁ⓗ࡟ࡑࡢάືࢆ㛤ጞࡋ࡚࠸ࡿࠋᮏᖺࡣ᪂ࡓ࡟ GCP ┬௧࡟ᑐᛂࡍࡿࠕ෌Ⓨཪࡣ
㞴἞ᛶ ALK 㝧ᛶᮍศ໬኱⣽⬊ࣜࣥࣃ⭘ᝈ⪅ࢆᑐ㇟࡜ࡋࡓ CH5424802 ࡢ➨ϩ┦ヨ㦂㸦་
ᖌ୺ᑟ἞㦂㸧ࠖ࠾ࡼࡧࠕᑠඣཬࡧⱝᖺᡂேࡢ㞴἞ᛴᛶࣜࣥࣃᛶⓑ⾑⑓ᝈ⪅࡟ᑐࡍࡿ࣎ࣝࢸࢰ
࣑ࣈే⏝ከ๣໬Ꮫ⒪ἲࡢᏳ඲ᛶཬࡧ⸆≀ືែࢆ᳨ウࡍࡿ➨Ϩ┦ヨ㦂㸦་ᖌ୺ᑟ἞㦂㸧ࠖࡢࣔ
ࢽࢱࣜࣥࢢࢆᐇ᪋ࡋࠊ࢔࢝ࢹ࣑࢔ࣔࢽࢱ࣮࡜ࡋ࡚ࡢ㈐ົࢆᯝࡓࡋࡓࠋ
㸳㸬♫఍ⓗάືᐇ⦼
ᙜᐊࡣࠊ኱Ꮫ⑓㝔ࠊᅜ❧㧗ᗘᑓ㛛་⒪◊✲ࢭࣥࢱ࣮㸦NC㸧➼ࠊ⮫ᗋ◊✲࣭἞㦂ࢆ࣮ࣜࢻ
ࡍࡿ඲ᅜ 60 ᪋タࡀຍධࡋ࡚࠸ࡿࠕ⮫ᗋ◊✲࣭἞㦂άᛶ໬༠㆟఍ࠖࡸࠊ㛵ᮾಙ㉺ᆅ༊⟶ෆ࡟
࠾ࡅࡿ NCࠊNHOࠊᅜ❧ࣁࣥࢭࣥ⑓⒪㣴ᡤࡢ 41 ᪋タࡀຍ┕ࡍࡿࠕ㛵ಙᆅ༊ᅜ❧⑓㝔➼἞
㦂㐃⤡఍ࠖࡢ஦ົᒁࢆᢸࡗ࡚࠸ࡿࠋᮏᖺࡣ 2 ᭶ 27 ᪥࡟ࠕ➨ 25 ᅇ㛵ಙᆅ༊ᅜ❧⑓㝔➼἞㦂
㐃⤡఍ࠖࠊ6 ᭶ 26 ᪥࡟ࠕ➨ 11 ᅇ㛵ಙᆅ༊ᅜ❧⑓㝔➼἞㦂㐃⤡఍ᐇົ⪅఍㆟ࠖࢆࡑࢀࡒࢀ㛤
ദࡋࡓࠋ࠸ࡎࢀࡢ఍࡜ࡶࠊከᩘࡢ㛵ಀ⪅ࡀཧຍࡋࠊ᭱᪂ࡢ▱ぢࡸࢺࣆࢵࢡࢫࡢ᝟ሗඹ᭷ࡀ
࡞ࡉࢀࡿ࡜࡜ࡶ࡟ࠊ఍ဨྠኈ࡛ࠊ㈗㔜࡞᝟ሗ஺᥮ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡓࠋᙜᐊ࡛ࡣࠊࡇࢀࡽ
ࡢάືࢆ㏻ࡋࠊ௒ᚋࡶ⥅⥆ࡋ࡚ࠊᅜẸࠊ⾜ᨻࠊ〇⸆௻ᴗᅋయࠊ◊✲⪅࡜࡜ࡶ࡟ࠊ᪥ᮏࡢ་
⒪Ỉ‽ࡢྥୖࠊ᪥ᮏⓎࡢ࢖ࣀ࣮࣋ࢩࣙࣥࢆୡ⏺࡟Ⓨಙࡍࡿࡇ࡜࡟ᑡࡋ࡛ࡶᐤ୚࡛ࡁࢀࡤ࡜
⪃࠼࡚࠸ࡿࠋ
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ࠝ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊࠞ
Corrective and Preventative Actions (CAPA)࡟ࡼࡿ㐓⬺㜵Ṇ࡬ࡢྲྀࡾ⤌ࡳ
✄ྜྷ⨾⏤⣖ࠊᮏஂ⨾Ꮚࠊᔱᒸ ⥳ࠊ⸨ᕝ཭Ꮚࠊ㧘ᮌᜨ⨾
➉ୗᬛᜨࠊ▼஭཭㔛ࠊ㔠ග❶Ụࠊ୰ᕝ⏤⨾ࠊ㏆⸨┤ᶞ
(㹌㹆㹍ᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ)
せ ⣙
ᙜᐊ࡛ࡣࠊ἞㦂ᐇ᪋ィ⏬᭩➼ࡢ㐓⬺㜵Ṇ࡬ࡢྲྀࡾ⤌ࡳ࡜ࡋ࡚ࠊ་⸆ရ〇㐀࡟࠾ࡅࡿရ㉁
⟶⌮㒊㛛࡛ྲྀࡾධࢀࡽࢀ࡚࠸ࡿ CAPA ࡢᴫᛕࢆᑟධࡋࠊၥ㢟ࡢ᰿ᮏⓗ࡞ཎᅉࢆぢᴟࡵࠊ෌
Ⓨ㜵Ṇ⟇ࢆ⪃᱌ࡋ࡚࠸ࡃ QM ࢩࢫࢸ࣒ࡢ☜❧࡜ࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝ࡜ࡋ࡚ࡢά⏝ࢆヨࡳࡓࠋ
5 Whys ࢆ⏝࠸࡚෌Ⓨ㜵Ṇ⟇ࢆ⪃᱌ࡋ࡚࠸ࡃࢶ࣮ࣝࢆ⪃᱌ࡋࠊᐇ㝿࡟㉳ࡇࡗࡓ஦౛࡟ࡘ࠸
࡚ࠊCAPA sheet ࢆ⏝࠸࡚෌Ⓨ㜵Ṇ⟇ࢆ᳨ウࡋࡓࠋࡲࡓࠊࡑࡢ᝟ሗࢆά⏝ࡋࡓ CRC ᩍ⫱⏝
ࡢࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝࢆసᡂࡋࡓࠋᢸᙜ⪅㛫࡛ᨵၿ⟇ࢆ⪃࠼ࡿࡇ࡜࡛ࠊ஫࠸ࡢᴗົࣉࣟࢭ
ࢫࡢ☜ㄆ࡜࡞ࡾࠊຠᯝⓗ࡞෌Ⓨ㜵Ṇ⟇ࢆㅮࡌࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡲࡓࠊ᝟ሗࢆ㞟⣙ࡍࡿࡇ࡜
࡛ࠊᐇ㊶ⓗ࡞ࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝ࡜ࡋ࡚ࡢά⏝ࡶྍ⬟࡛࠶ࡿ࡜⪃࠼ࡿࠋ
┠ ⓗ
⡿ᅜ࡛ࡣ Quality Management㸦QM㸧ࡀ㔜せどࡉࢀ࡚࠾ࡾࠊACRP Global
Conference2014 ࡛ࡣ CAPA ࡟㛵ࡍࡿㅮ₇➼ࡀከࡃⓎ⾲ࡉࢀ࡚࠸ࡓࠋCAPA ࡢᴫᛕࡣ་⸆
ရ〇㐀࡟࠾ࡅࡿရ㉁⟶⌮㒊㛛࡛ࡍ࡛࡟ᾐ㏱ࡋ࡚࠸ࡿࡀࠊ㏆ᖺࡣ἞㦂ᐇ᪋᪋タ࡟࠾࠸࡚ࡶ㐺
⏝ࡋ࡚࠸ࡃࡇ࡜ࡀồࡵࡽࢀ࡚ࡁ࡚࠸ࡿࠋࡑࡇ࡛ࠊᙜᐊ࡛ࡣ CAPA ࡢᴫᛕࢆᑟධࡋࠊࣉࣟࢺ
ࢥ࣮ࣝ㐓⬺➼࡟ࡘ࠸࡚ၥ㢟ࡢ᰿ᮏⓗ࡞ཎᅉࢆぢᴟࡵࠊ෌Ⓨ㜵Ṇ⟇ࢆ⪃᱌ࡋ࡚࠸ࡃ QM ࢩࢫ
ࢸ࣒ࡢ☜❧࡜ࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝ࡜ࡋ࡚ࡢά⏝ࢆヨࡳࡓࡢ࡛ሗ࿌ࡍࡿࠋ
᪉ ἲ
5 Whys ࢆ⏝࠸࡚෌Ⓨ㜵Ṇ⟇ࢆ⪃᱌ࡋ࡚࠸ࡃࢶ࣮ࣝࢆ⪃᱌ࡋࠊᐇ㝿࡟㉳ࡇࡗࡓ஦౛࡟ࡘ
࠸࡚ࠊCAPA sheet ࢆ⏝࠸࡚෌Ⓨ㜵Ṇ⟇ࢆ᳨ウࡋࡓࠋࡲࡓࠊࡑࡢ᝟ሗࢆά⏝ࡋࡓ CRC ᩍ⫱
⏝ࡢࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝࢆసᡂࡋࡓࠋ
⤖ ᯝ
ᙜ㝔࡛ࡣ་⒪Ᏻ඲⟶⌮ࢩࢫࢸ࣒ࡀᑟධࡉࢀ࡚࠾ࡾࠊ࢖ࣥࢩࢹࣥࢺ࣏࣮ࣞࢺࡢ⟶⌮ࠊ᝟ሗ
ඹ᭷ࡀࡉࢀ࡚࠸ࡿࠋ἞㦂࡟࠾࠸࡚ࡣࠊ㐓⬺࡬ࡢ෌Ⓨ㜵Ṇ⟇ࡣྛ⮬࡟௵ࡉࢀ࡚࠾ࡾࠊࡑࡢෆ
ᐜ࡟ࡘ࠸࡚ࡣ࣑࣮ࢸ࢕ࣥࢢ࡛ሗ࿌ࡍࡿࡢࡳ࡛࠶ࡗࡓࠋ௒ᅇࠊCAPA ࡢᴫᛕࡢᑟධ࡟࠶ࡓࡾࠊ
་⒪Ᏻ඲⟶⌮ࢩࢫࢸ࣒ࡢᑟධࢆ᳨ウࡋࡓࡀࠊࡑࡢᡭἲࡀ἞㦂ࡢ QM ࡜ࡋ࡚ࡣ୙༑ศ࡛࠶ࡿ
࡜⪃࠼ࠊ5 Whys ࢆ⏝࠸ࡓ CAPA sheet ࢆ⪃᱌ࡋࡓࠋࡲࡓࠊᐇ㝿࡟㉳ࡇࡗࡓ㐓⬺஦౛࡟ࡘ
࠸࡚ᢸᙜ⪅㛫࡛ 5 Whys ࢆグ㍕ࡋࠊ᰿ᮏⓗ࡞ཎᅉࡢぢᴟࡵ࡜෌Ⓨ㜵Ṇ⟇ࡢ⪃᱌࡟ྲྀࡾ⤌ࢇ
ࡔࠋࡇࡢྲྀࡾ⤌ࡳ࡟ࡼࡗ࡚ࠊ᳨ᰝ࣐ࢽࣗ࢔ࣝࡢグ㍕୙ഛࡸᥦ౪㈨ᮦࡢၥ㢟ⅬࡀⓎぬࡋࠊຠ
ᯝⓗ࡞෌Ⓨ㜵Ṇ⟇ࢆㅮࡌࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡲࡓࠊᢸᙜ⪅㛫࡛ྲྀࡾ⤌ࡴࡇ࡜࡛ࠊᴗົࣉࣟࢭ
― 25 ―
ࢫࢆ┦஫࡛☜ㄆࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋసᡂࡋࡓ CAPA sheet ࡢෆᐜࡣࢫࢱࢵࣇ㛫࡛᝟ሗඹ᭷
࡛ࡁࡿࡼ࠺ࢫࢱࢵࣇ࣑࣮ࢸ࢕ࣥࢢ࡛ሗ࿌ࡋࠊࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝ࡜ࡋ࡚ಖ⟶ࡋ࡚࠸ࡃࡇ࡜
࡜ࡋࡓࠋࡉࡽ࡟ࠊCRC ᩍ⫱ࢶ࣮ࣝ࡜ࡋ࡚ࠊ㐣ཤ࡟㉳ࡇࡗࡓ஦౛ࢆᥦ♧ࡋ 5 Whys ࢆ⏝࠸࡚
ண㜵⟇ࢆ⪃࠼࡚࠸ࡃ CAPA sheet for training ࢆ⪃᱌ࡋࡓࠋ
἞㦂ᐇ᪋᪋タ࡟࠾ࡅࡿ CAPA ࡢᴫᛕࢆᑟධࡋࡓ QM ࢩࢫࢸ࣒ࡣࣉࣟࢺࢥ࣮ࣝ㐓⬺ࡢຠᯝ
ⓗ࡞෌Ⓨ㜵Ṇ⟇ࡢ⪃᱌࡟᭷⏝࡛࠶ࡾࠊᢸᙜ⪅㛫࡛ᨵၿ⟇ࢆ⪃࠼ࡿࡇ࡜࡛ࠊ஫࠸ࡢᴗົࣉࣟ
ࢭࢫࡢ☜ㄆ࡜࡞ࡿࠋࡲࡓࠊ᝟ሗࢆ㞟⣙ࡍࡿࡇ࡜࡛ࠊᐇ㊶ⓗ࡞ࢺ࣮ࣞࢽࣥࢢࢶ࣮ࣝ࡜ࡋ࡚ࡢ
ά⏝ࡶྍ⬟࡛࠶ࡿ࡜⪃࠼ࡿࠋ
― 26 ―
ࠝ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊࠞ
)LUVWLQKXPDQ ➨Ϩ┦་ᖌ୺ᑟ἞㦂
ࡢᐇ᪋ࢆ㏻ࡋ࡚ࡢホ౯࡜⪃ᐹ
㧘ᮌ ᜨ⨾ࠊ⸨ᕝ ཭Ꮚࠊ➉ୗ ᬛᜨࠊඵ௦ ᬛᏊࠊ✄ྜྷ⨾⏤⣖ࠊ㔠ග ❶Ụࠊ୰ᕝ ⏤⨾ࠊ ᮏஂ⨾Ꮚࠊᔱᒸ ⥳ࠊ▼஭ ཭㔛ࠊ㏆⸨ ┤ᶞࠊ຾ᾏ Ꮫࠊ༓⏣ ᫀஅࠊஂಖ⏣⠜ྖࠊ
㇂ᆅ ㇏ࠊ㕥ᮌ ⩏ᙪࠊᵻᒣ ᖾᙪ
㹌㹆㹍ᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ
せ ⣙
ᙜᐊ࡛ࡣࡌࡵ࡚ )LUVWLQKXPDQ㸦),+㸧࡛࠶ࡿ⏕≀Ꮫⓗ〇๣ࡢ➨Ϩ┦་ᖌ୺ᑟ἞㦂ࢆᐇ
᪋ࡋࡓࡇ࡜࠿ࡽࠊ&5& ཬࡧ἞㦂஦ົᒁࡢ❧ሙ࠿ࡽࠊࡑࡢホ౯࡜ࠊ௒ᚋࡢ➨Ϩ┦་ᖌ୺ᑟ἞
㦂࡬ࡢཷࡅධࢀయไࢆ࡝࠺ᩚ࠼࡚࠸ࡃ࠿ࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊࡇࢀࡲ࡛ࡢ་ᖌ୺ᑟ἞㦂
➼ࡢ⤒㦂ࡸࠊ᪥ࡈࢁࡢ㛵㐃㒊㛛࡜ࡢ㐃ᦠࡀ෇⁥࡛࠶ࡗࡓࡇ࡜ࠊ㔜⠜࡞᭷ᐖ஦㇟ࡢⓎ⏕ࡀ࡞
࠿ࡗࡓࡇ࡜ࡶ࠶ࡾࠊ෇⁥࠿ࡘ㐺ṇ࡟ᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋ
),+ ἞㦂ࡣ≉࡟Ᏻ඲ᛶࢆ᭱኱㝈㔜どࡋ࡞ࡀࡽࠊࡼࡾៅ㔜࡟ᐇ᪋ࡍࡿᚲせࡀ࠶ࡿࠋࡑࡢࡓ
ࡵ௒ᚋࠊ),+ ἞㦂ࢆᐇ᪋ࡍࡿᶵ఍ࡀ࠶ࡿሙྜ࡟ࡣࠊ᭷ᐖ஦㇟࡞࡝᝿ᐃ࡛ࡁ࡞࠸஦㇟࡟ࡶᑐ
ᛂ࡛ࡁࡿࡼ࠺࡞ุ᩿⬟ຊ࡜ᐇ᪋యไᩚഛࡀᚲせ࡜⪃࠼ࡿࠋ
┠ ⓗ
ᙜ㝔ࡣ⑓ᗋᩘ ᗋࠊデ⒪⛉ ⛉࠿ࡽ࡞ࡿ᪋タ࡛࠶ࡿࠋᙜᐊ࡛ࡣࡌࡵ࡚ )LUVWLQKXPDQ
࡛࠶ࡿ⏕≀Ꮫⓗ〇๣ࡢ➨Ϩ┦་ᖌ୺ᑟ἞㦂ࢆᐇ᪋ࡋࡓࡇ࡜࠿ࡽࠊࡑࡢホ౯࡜ࠊ௒ᚋࡢ➨Ϩ
┦་ᖌ୺ᑟ἞㦂࡬ࡢཷࡅධࢀయไࢆ࡝࠺ᩚ࠼࡚࠸ࡃ࠿ࢆ᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊ἞㦂࡟ᑐࡍ
ࡿ㐃ᦠཬࡧᐇ᪋యไࡀ࡜ࢀ࡚࠸ࡓࡓࡵ෇⁥࡟㐍ࡵࡿࡇ࡜ࡀ࡛ࡁࠊ἞㦂ࢆ⤊஢ࡍࡿᐇ⦼࡟ࡘ
࡞ࡀࡗࡓࠋ
᪉ ἲ
἞㦂ᐇ᪋࡟࠶ࡓࡾୗグᴗົ࡟ࡘ࠸࡚ྲྀࡾ⤌ࢇࡔࠋ
ձ ἞㦂ㄪᩚ஦ົᒁ࡜ࡢ㐃ᦠ
ղ ೺ᖖே࢝ࣝࢸࡢసᡂ࡜ධ㝔➼ࡢ஦ົᡭ⥆ࡁࡢ☜ಖ
ճ ⿕㦂⪅ເ㞟ࢧ࢖ࢺࡢά⏝࡜ࢫࢣࢪ࣮ࣗࣝㄪᩚ
մ ᩆ࿨ᩆᛴ་࡬ࡢ༠ຊ౫㢗࡜ከデ⒪⛉ඹྠ࡟ࡼࡿ἞㦂ᐇ᪋యไࡢ☜ಖ
յ Ᏻ඲࠿ࡘ෇⁥࡞యไࢆᅗࡿࡇ࡜ࡀ࡛ࡁࡿ⑓Ჷࡢ㑅ᐃ࡜ㄪᩚ
ն ࢔࢝ࢹ࣑࢔ࣔࢽࢱ࣮ࡢཷࡅධࢀ
շ ◊✲㈝ࡢ㓄ศ
⤖ ᯝ
㞴᫆ᗘࡢ㧗࠸➨Ϩ┦་ᖌ୺ᑟ἞㦂ࢆᏳ඲࡟㐙⾜࡛ࡁࡿࡼ࠺ࠊࡇࢀࡲ࡛ࡢ་ᖌ୺ᑟ἞㦂ࡢ
― 27 ―
⤒㦂ࢆά࠿ࡋࠊ㛵㐃㒊㛛࡜ࡢ㐃ᦠࢆᅗࡾࠊయไᩚഛࢆ࠾ࡇ࡞ࡗࡓ⤖ᯝࠊୗグࡢ࡜࠾ࡾ෇⁥
࠿ࡘ㐺ṇ࡟἞㦂ࢆᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡲࡓࠊᐇ᪋୰࡟ࡣᙜึ᝿ᐃࡋ࡚࠸࡞࠿ࡗࡓ஦᯶
➼ࡶ㉳ࡇࡗࡓࡀࠊ἞㦂࡟ᑐࡍࡿ㐃ᦠཬࡧᐇ᪋యไࡀ࡜ࢀ࡚࠸ࡓࡓࡵ෇⁥࡟㐍ࡵࡿࡇ࡜ࡀ࡛
ࡁࠊ἞㦂ࢆ⤊஢ࡍࡿᐇ⦼࡟ࡘ࡞ࡀࡗࡓࠋ
ձ ἞㦂ㄪᩚ஦ົᒁ࡜ࡢ㐃ᦠ
࢔἞㦂ㄪᩚ஦ົᒁ࡜ඹྠ࡛ࢫࢱ࣮ࢺ࢔ࢵࣉ࣑࣮ࢸ࢕ࣥࢢࢆ㛤ദࠋ
࢖἞㦂㛤ጞ┤๓࡟ &5& ࡼࡾ་ᖌ࣭⑓Ჷᖌ㛗࡬ࢫࢱ࣮ࢺ࢔ࢵࣉ࣑࣮ࢸ࢕ࣥࢢ
ࢆ㛤ദࡋࠊලయⓗ࡞ᙺ๭ศᢸࢆ᫂☜࡟ࡍࡿࠋ
ղ ೺ᖖே࢝ࣝࢸࡢసᡂ࡜ධ㝔➼ࡢ஦ົᡭ⥆ࡁࡢ☜ಖ
࢔஦๓࡟་஦ㄢ࡬⿕㦂⪅᝟ሗࢆఏ࠼ࠊධ㝔ࡢᡭ⥆ࡁࢆࢫ࣒࣮ࢬ࡟࡞ࡿࡼ࠺㓄
៖ࠋ
࢖᳨ᰝࡢ࣮࢜ࢲ࣮ࢭࢵࢺࠊ⸆๣࣐ࢫࢱ࣮Ⓩ㘓ࠊほᐹ㡯┠ࡢࢸࣥࣉ࣮ࣞࢺࠊࣇ
࣮ࣟ࡟࡞ࡗࡓ࣮࣡ࢡࢩ࣮ࢺసᡂࠋ
ճ ⿕㦂⪅ເ㞟ࢧ࢖ࢺࡢά⏝࡜ࢫࢣࢪ࣮ࣗࣝㄪᩚ
࢔ເ㞟㛤ጞࡋࡓ᪥ࡼࡾᛂເ࠶ࡾࠊ▷ᮇ㛫ࡢࢫࢣࢪ࣮ࣗࣝࡢ୰࡛⿕㦂⪅᮶㝔ࡢ
᪥⛬ࢆ⤌ࡴࡇ࡜ࡀฟ᮶ࡓࠋ
մ ᩆ࿨ᩆᛴ་࡬ࡢ༠ຊ౫㢗࡜ከデ⒪⛉ඹྠ࡟ࡼࡿᐇ᪋యไ☜ಖ
࢔⥲ྜෆ⛉་ᖌࡼࡾ ,&࣭ᢞ୚๓デᐹ࣭ὀᑕ࣭ᢞ୚ᚋデᐹࡢᐇ᪋ࠋ
࢖ᩆ࿨་ᖌ࡟ࡼࡿኪ㛫ᖏデᐹࢆ⾜࠸ࠊグ㘓࡟ṧࡍࠋ
࢘ᚠ⎔ჾ⛉་ᖌ㸦ᙜᐊ㛗㸧ࢫࢡ࣮ࣜࢽࣥࢢ᳨ᰝࡢ␗ᖖ್ࡢ☜ㄆ࠾ࡼࡧ᭷ᐖ஦
㇟ࡢุ᩿ࠋ
յ Ᏻ඲࠿ࡘ෇⁥࡞యไࢆᅗࡿࡇ࡜ࡀ࡛ࡁࡿ⑓Ჷࡢ㑅ᐃ࡜ㄪᩚ
࢔ ᫬㛫ࣔࢽࢱࣜࣥࢢ࣭ᛴኚ᫬ᑐᛂྍ⬟ࠋ
࢖&5& ࡼࡾ⑓Ჷ┳ㆤᖌ࡬἞㦂ᴫせ࡜ᐇ᪋ෆᐜ࡟ࡘ࠸࡚ㄝ᫂ࠋ
ն ࢔࢝ࢹ࣑࢔ࣔࢽࢱ࣮ࡢཷࡅධࢀ
࢔6'9 ᅇ㸦㹼 ᅇ㸭᭶㸧
࢖┘ᰝ ᅇ
࢘'0 ࠿ࡽࡢࢡ࢚ࣜ⥲ᩘ շ ◊✲㈝ࡢ㓄ศ
࢔㛵㐃㒊㛛ࡢ㈐௵⪅࡜◊✲㈝ࡢ㔠㢠ࢆㄪᩚࡋྜពࡋࡓࠋ
⪃ ᐹ
ࡇࢀࡲ࡛ࠊ་ᖌ୺ᑟ἞㦂ࢆᙜ㝔࡛ࡣ ㄢ㢟⤒㦂ࡋ࡚࠸ࡿࡀࠊ➨Ϩ┦་ᖌ୺ᑟ἞㦂ࢆࡣࡌ
ࡵ࡚⤒㦂ࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋᙜヱ἞㦂ࡣᏳ඲ᛶࢆ᭱኱㝈㔜どࡋ࡞ࡀࡽࠊࡼࡾៅ㔜࡟ᐇ᪋ࡍ
ࡿᚲせࡀ࠶ࡾࠊ ᫬㛫┘どୗ࡟ࡼࡿ἞㦂ࡢᐇ᪋ࡀᚲせ࡛࠶ࡿࠋࡑࢀ࡟క࠸ࠊ἞㦂㈐௵་ᖌࠊ
ศᢸ་ᖌࠊ&5& ࡢ㈇ᢸࡣ኱ࡁࡃࠊࡑࡢᐇ᪋యไࡶ☜ᐇ࡟ᩚഛࡋ࡚࠾࠿࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
௒ᅇࡣ㔜⠜࠿ࡘ㔜኱࡞᭷ᐖ஦㇟ࡣⓎ⌧ࡇࡑࡋ࡞࠿ࡗࡓࡀࠊ௒ᚋࠊྠᵝࡢ἞㦂ࢆᐇ᪋ࡍࡿࡓ
ࡵ࡟ࡣࠊ᭷ᐖ஦㇟࡞࡝᝿ᐃ࡛ࡁ࡞࠸஦㇟࡟ࡶᑐᛂ࡛ࡁࡿࡼ࠺࡞ุ᩿⬟ຊ࡜ᐇ᪋యไᩚഛࡀ
ᚲせ࡜⪃࠼ࡿࠋ
― 28 ―
ࠝ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊࠞ
Portfolio ᐇ⏝∧ࡢసᡂ
̿ᶆ‽໬࣒࢝ࣜ࢟ࣗࣛ࡟ᇶ࡙࠸ࡓホ౯ࢶ࣮ࣝࢆ᳨ウ̿
✄ྜྷ ⨾⏤⣖㸯ࠊᚋ⸨ ⨾✑㸰ࠊ῝ᕝᜨ⨾Ꮚ㸱
(㹌㹆㹍ᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ㸯ࠊࢺࣛ࢖࢔ࢻࢪࣕࣃࣥᰴᘧ఍♫ ᪂⸆㛤
Ⓨᨭ᥼㒊㸰ࠊᗈᓥ኱Ꮫ⑓㝔 ⥲ྜ་⒪◊✲᥎㐍ࢭࣥࢱ࣮㸱)
せ ⣙
2013 ᖺᗘ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍ CRC ᾏእ◊ಟࡢ◊ಟဨ࡜ࡋ࡚࢜ࣛࣥࢲ࡟࠾ࡅࡿ CRC ࡢㄆ
ᐃไᗘࡸᩍ⫱࡟ࡘ࠸࡚▱ࡿᶵ఍ࢆᚓࡓࠋ࢜ࣛࣥࢲ࡟࠾ࡅࡿ Portfolio ࢆ⏝࠸ࡓ CRC ࡢᩍ⫱
ࣉࣟࢢ࣒ࣛࡣࠊᏛ⩦㌶㊧ࡢ୍ඖ໬࡜ࠊࢹ࢕ࢫ࢝ࢵࢩࣙࣥᙧᘧࡢᩍ⫱ࢆ㔜せどࡋ࡚࠸ࡿࠋࡑ
ࡇ࡛ࠊ᪥ᮏࡢ CRC ᩍ⫱࡬ࡢά⏝ࢆ┠ⓗ࡜ࡋࠊPortfolio ᐇ⏝∧ࢆసᡂࡋࡓࠋᅜ㝿ඹྠ἞㦂
ࡢᑐᛂࡶど㔝࡟ධࢀࠊⱥㄒ∧ࡢ CV ࡜ Training Log ࢩ࣮ࢺࢆྲྀࡾධࢀࡓᵓᡂࢆ⪃᱌ࡋࡓࠋ
Competencies㸦⬟ຊ㸧࡜ࡋ࡚ࠊ
ࠕ⮫ᗋ◊✲࣭἞㦂άᛶ໬ 5 ࠿ᖺィ⏬ 2012ࠖ࡟࠾ࡅࡿࠕ⮫ᗋ
◊✲ࢥ࣮ࢹ࢕ࢿ࣮ࢱ࣮㣴ᡂ࣒࢝ࣜ࢟ࣗࣛࡢᶆ‽໬࡟㛵ࡍࡿ◊✲⌜ࠖࡼࡾ⟇ᐃࡉࢀࡓึ⣭⪅/
ୖ⣭⪅ CRC 㣴ᡂ࣒࢝ࣜ࢟ࣗࣛ࡟ᥖࡆࡽࢀ࡚࠸ࡿ 14 ࡢ Content Areas㸦ᙺ๭࣭㈐ົ㸧 ࢆ
ྲྀࡾධࢀࠊྛ Competencies㸦⬟ຊ㸧ࡢ⮬ᕫホ౯࡜ࡑࡢෆᐜ࡟ࡘ࠸࡚ホ౯⪅࡜ࢹ࢕ࢫ࢝ࢵ
ࢩࣙࣥࡋࠊࢹ࢕ࢫ࢝ࢵࢩࣙࣥࡢෆᐜࡸࢥ࣓ࣥࢺࢆグ㘓ࡋ࡚࠸ࡃᙧᘧ࡜ࡋࡓࠋࡲࡓࠊྛᮇ㛫
࡟࠾ࡅࡿ⮬ᕫ㛤Ⓨࣉࣛࣥ㸦POP㸧࡜⾜ືィ⏬㸦PAP㸧ࢆタᐃࡋࠊẁ㝵ⓗ࡟⮬ᕫ฿㐩┠ᶆࢆ
ホ౯ࡋ࡚࠸ࡃࡇ࡜࡛ࠊྛࣞ࣋ࣝ࡟ᛂࡌࡓࢫ࢟ࣝ࢔ࢵࣉ࡜ࣔࢳ࣮࣋ࢩࣙࣥࡢྥୖ࡟⧅ࡀࡿ࡜
⪃࠼ࡿࠋ௒ᚋࡣࠊྛ᪋タ࡟࠾ࡅࡿά⏝࡜㐺ษ࡞ぢ┤ࡋࢆࡍࡿࡇ࡜࡛ࠊࡉࡽ࡞ࡿᐇ⏝໬ࢆᅗ
ࡾࡓ࠸ࠋ
┠ ⓗ
㏆ᖺࠊ᪥ᮏࡢᅜ㝿ඹྠ἞㦂ࡢቑຍ࡟క࠸ CRC ࡢᴗົࡀከᵝ໬࣭↹㞧໬ࡋ࡚࠸ࡃ୰࡛ࠊ
CRC ࡢேᮦ⫱ᡂཬࡧ☜ಖࡢᚲせᛶࡀồࡵࡽࢀࠊ
ࠕ⮫ᗋ◊✲࣭἞㦂άᛶ໬ 5 ࠿ᖺィ⏬ 2012ࠖ
࡟࠾࠸࡚◊ಟෆᐜ➼ࡢᩚഛࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋ➨ 35 ᅇ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍Ꮫ⾡⥲఍࡛ࡣࠊ
2013 ᖺᗘ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍ CRC ᾏእ◊ಟࡢ◊ಟဨ࡜ࡋ࡚ࠊ᪥ᮏࡢ CRC ᩍ⫱࡟ά⏝ࡍࡿ
ࡇ࡜ࡣ᭷┈࡛࠶ࡿ࡜ሗ࿌ࡋࡓࠋࡑࡇ࡛ࠊ௒ᅇࡣ᪥ᮏࡢ CRC ᩍ⫱࡬ࡢά⏝ࢆ┠ⓗ࡜ࡋࠊ
Portfolio ᐇ⏝∧ࢆసᡂࡋࡓࡢ࡛ሗ࿌ࡍࡿࠋ
᪉ ἲ
᪥ᮏ࡟࠾ࡅࡿ Portfolio ᐇ⏝∧ࡢෆᐜࢆ᳨ウࡋࠊ௨ୗࡢᇶᮏᵓᡂ࡛సᡂࡋࡓࠋ
1)Curriculum Vitae㸦CV㸧࡜ Training Log
2)ึ⣭⪅ CRC/ୖ⣭⪅ CRC 㣴ᡂ࣒࢝ࣜ࢟ࣗࣛ࡟ᇶ࡙࠸ࡓ Competencies ࡜ホ౯
3)⫋ᴗ࢔࢖ࢹࣥࢸ࢕ࢸ࢕ㄪᰝ
4)⮬ᕫ㛤Ⓨࣉࣛࣥ㸦POP㸧࡜⾜ືィ⏬㸦PAP㸧
― 29 ―
⤖ ᯝ
ᅜ㝿ඹྠ἞㦂࡟࠾࠸࡚ࠊCRC ࡢⱥㄒ∧ CV ࡢᥦ♧ࡸ Training ᐇ᪋ࡢ᭷↓ࡀồࡵࡽࢀࡿ
ࡇ࡜ࡀ࠶ࡿࠋࡑࡇ࡛ࠊPortfolio ᐇ⏝∧࡛ࡣࡑࡢࡼ࠺࡞ᅜ㝿ඹྠ἞㦂ࡢᑐᛂࡶど㔝࡟ධࢀࠊ
ⱥㄒ∧ࡢ CV ࡜ Training Log ࢩ࣮ࢺࢆྲྀࡾධࢀࡓᵓᡂࢆ⪃᱌ࡋࡓࠋPortfolio ᐇ⏝∧࡟࠾
ࡅࡿ Competencies㸦⬟ຊ㸧࡜ࡋ࡚ࠊࠕ⮫ᗋ◊✲࣭἞㦂άᛶ໬ 5 ࠿ᖺィ⏬ 2012ࠖ࡟࠾ࡅࡿ
ࠕ⮫ᗋ◊✲ࢥ࣮ࢹ࢕ࢿ࣮ࢱ࣮㣴ᡂ࣒࢝ࣜ࢟ࣗࣛࡢᶆ‽໬࡟㛵ࡍࡿ◊✲⌜ࠖࡼࡾ⟇ᐃࡉࢀࡓ
ึ⣭⪅/ୖ⣭⪅ CRC 㣴ᡂ࣒࢝ࣜ࢟ࣗࣛ࡟ᥖࡆࡽࢀ࡚࠸ࡿ 14 ࡢ Content Areas㸦ᙺ๭࣭㈐ົ㸧
ࢆྲྀࡾධࢀࡓࠋ࢜ࣛࣥࢲ∧࡜ྠᵝࠊ⬟ຊࣞ࣋ࣝࡣ㸵ẁ㝵ࡢホ౯࡛⮬ᕫホ౯ࡋ࡚࠸ࡃࡇ࡜࡜
ࡋࠊホ౯⪅࡟ࡼࡿ᭱⤊ホ౯ࡣࠕ฿㐩࡛ࣞ࣋ࣝࠖホ౯ࡍࡿࡇ࡜࡜ࡋࡓࠋホ౯ᮇ㛫ࡣࠊ➨㸯ᮇ
㸦1 ᖺᮍ‶㸧ࠊ
➨㸰ᮇ㸦1 ᖺ௨ୖ 3 ᖺᮍ‶㸧ࠊ➨㸱ᮇ
㸦3 ᖺ௨ୖ㸧ࡢ 3 ᮇ࡟ศࡅࠊྛ Competencies
㸦⬟ຊ㸧࡟ࡘ࠸࡚ྛᮇ㛫ࡢᮇᮎ࡟࠾ࡅࡿ฿㐩⬟ຊࣞ࣋ࣝࢆ᭩ࡁධࢀࡿࡼ࠺࡟ࡋࡓࠋ➨㸱ᮇ
࡟࠾࠸࡚ࡣಶேࡢࣞ࣋ࣝ࡟ྜࢃࡏ࡚ホ౯ᮇ㛫ࢆタᐃࡋ࡚࠸ࡃࡇ࡜࡜ࡋࡓࠋホ౯ࢩ࣮ࢺࡣྛ
ᮇ㛫࡟࠾ࡅࡿ┠ᶆ࡜ᮇ㤳ࠊ୰㛫ࠊᮇᮎ࡟࠾ࡅࡿ⬟ຊࣞ࣋ࣝࡢ⮬ᕫホ౯ࢆ୍ඖⓗ࡟᭩ࡁධࢀ
ࡿᙧᘧ࡜ࡋࠊ┠ᶆ⬟ຊࣞ࣋ࣝ࡬ࡢ฿㐩≧ἣࡢᢕᥱࢆᅗࡗࡓࠋࡲࡓࠊ࢜ࣛࣥࢲ࡛㔜せどࡉࢀ
࡚࠸ࡓࢹ࢕ࢫ࢝ࢵࢩࣙࣥᙧᘧࡢᩍ⫱ࢆྲྀࡾධࢀࠊᮇ㤳ࠊ୰㛫ࠊᮇᮎ࡟࠾࠸࡚⬟ຊࣞ࣋ࣝࢆ
⮬ᕫホ౯ࡋࡓᚋࠊホ౯⪅࡜ࡢࢹ࢕ࢫ࢝ࢵࢩࣙࣥࢆ⾜࠸ࠊ⮬ᕫホ౯࡟㛵ࡍࡿㄝ᫂ࢆ᭩ࡁධࢀ
࡚࠸ࡃࡇ࡜࡜ࡋࡓࠋ✚ᴟᛶࡢྥୖࡸከゅⓗ࡞どⅬࢆព㆑ࡋࡓ⫋ᴗ࢔࢖ࢹࣥࢸ࢕ࢸ࢕ࡢグ㍕
ࡣ᪥ᮏࡢ CRC ᩍ⫱࡟᭷┈࡛࠶ࡿ࡜⪃࠼ࠊPortfolio ᐇ⏝∧࡬ᑟධࡋࡓࠋ⮬ᕫ㛤Ⓨࣉࣛࣥ
㸦POP㸧࡜⾜ືィ⏬㸦PAP㸧࡛ࡣࠊྛᮇ㛫ࡢᮇ㤳࡟ࠊ⮬ศࡀ≉࡟ࢫ࢟ࣝ࢔ࢵࣉࢆᅗࡾࡓ࠸
⬟ຊ࡟ࡘ࠸࡚⮬ᕫ㛤Ⓨࣉࣛࣥ㸦POP㸸࠸ࡘࡲ࡛࡟ࠊఱࢆࠊ࡝ࡢỈ‽ࡲ࡛㸧࡜ࠊࡑࢀ࡟ᑐࡍ
ࡿ⾜ືィ⏬㸦PAP㸸┠ᶆࢆ㐩ᡂࡍࡿࡓࡵࡢᐇ⾜ィ⏬㸧ࢆ❧࡚ࡿࠋࡑࡢෆᐜ࡟ࡘ࠸࡚ホ౯⪅
࡜ࢹ࢕ࢫ࢝ࢵࢩࣙࣥࡋࠊࢹ࢕ࢫ࢝ࢵࢩࣙࣥࡢෆᐜࡸࢥ࣓ࣥࢺࢆグ㘓ࡋ࡚࠸ࡃࠋ୰㛫ࠊᮇᮎ
࡛ࡣ㐩ᡂ≧ἣሗ࿌㸦㐩ᡂ≧ἣࠊ≧ἣኚ໬ࠊࡑࡢ௚≉➹ࡍ࡭ࡁ஦㡯㸧ࢆ⾜࠸ࠊホ౯⪅࡜ࢹ࢕
ࢫ࢝ࢵࢩࣙࣥࡋࠊࡑࡢෆᐜࢆグ㘓ࡍࡿࠋホ౯⪅ࡣ᭱⤊ホ౯࡟࠾࠸࡚฿㐩ࣞ࣋ࣝࢆホ౯ࡋグ
㘓ࡍࡿࡇ࡜࡜ࡋࡓࠋホ౯᫬ᮇࡣྛ Competencies㸦⬟ຊ㸧ࡢホ౯ࢱ࢖࣑ࣥࢢ࡜ྜࢃࡏࠊ
POP/PAP ࡢホ౯࡟࠾࠸࡚ࡶࢹ࢕ࢫ࢝ࢵࢩࣙࣥᙧᘧࡢᩍ⫱ࢆྲྀࡾධࢀࡓࠋ
Portfolio ᐇ⏝∧ࡣࠊ࢜ࣛࣥࢲ∧࡜ྠᵝ࡟ྛ Competencies㸦⬟ຊ㸧ࡢ⮬ᕫホ౯࡜ࢹ࢕ࢫ
࢝ࢵࢩࣙࣥᙧᘧࡢᩍ⫱ࢆྲྀࡾධࢀ࡚సᡂࡋࡓࠋ Competencies㸦⬟ຊ㸧ࡣࠊᶆ‽໬࢝ࣜ࢟
࣒ࣗࣛ࡟ᥖࡆࡽࢀ࡚࠸ࡿ 14 ࡢ Content Areas ࡟ᇶ࡙࠸࡚ホ౯ࡍࡿࡇ࡜࡛ࠊ฼⏝⠊ᅖࡢᗈ
࠸ホ౯ࢶ࣮ࣝ࡟࡞ࡿ࡜⪃࠼ࡽࢀࡿࠋホ౯ᮇ㛫ࡣ 3 ᮇ࡟ศࡅࡿࡇ࡜࡛ࠊྛ⮬ࡢࣞ࣋ࣝ࡟ᛂࡌ
࡚タᐃ࡛ࡁࡿࡼ࠺⪃᱌ࡋࡓࠋྛᮇ㛫࡟࠾ࡅࡿ⮬ᕫ㛤Ⓨࣉࣛࣥ㸦POP㸧࡜⾜ືィ⏬㸦PAP㸧
ࢆタᐃࡋࠊẁ㝵ⓗ࡟⮬ᕫ฿㐩┠ᶆࢆホ౯ࡋ࡚࠸ࡃࡇ࡜࡛ࠊྛࣞ࣋ࣝ࡟ᛂࡌࡓࢫ࢟ࣝ࢔ࢵࣉ
࡜ࣔࢳ࣮࣋ࢩࣙࣥࡢྥୖ࡟⧅ࡀࡿ࡜⪃࠼ࡿࠋࡲࡓࠊᅜ㝿ඹྠ἞㦂࡬ࡢయไᩚഛࢆど㔝࡟ධ
ࢀ࡚ CV ⱥㄒ∧࡜ Training Log ࢆྲྀࡾධࢀࠊホ౯ࢩ࣮ࢺࡣᏛ⩦㌶㊧ࡢ୍ඖ໬ࢆព㆑ࡋ࡚స
ᡂࡋࡓࠋ௒ᚋࡣࠊྛ᪋タ࡟࠾ࡅࡿά⏝࡜㐺ษ࡞ぢ┤ࡋࢆࡍࡿࡇ࡜࡛ࠊࡉࡽ࡞ࡿᐇ⏝໬ࢆᅗ
ࡾࡓ࠸ࠋ
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㻌
㻌
㻌
㻌
どぬ◊✲㒊㻌
㻌
㒊㛗㻌 㻌 㻌 ゅ⏣㻌 ࿴⦾㻌
㻌
どぬ⏕⌮Ꮫ◊✲ᐊ㻌 㻌 㻌 ゅ⏣㻌 ࿴⦾㻌 㒊㛗ව௵㻌
䝻䞊䝡䝆䝵䞁◊✲ᐊ㻌 㻌 㻌 㔝⏣㻌 ᚭ㻌 ᐊ㛗㻌
║⛉␿Ꮫ◊✲ᐊ㻌 㻌 㻌 㻌
㸺どぬ◊✲㒊㸼
㸦ձどぬ⏕⌮Ꮫ◊✲ᐊࠊղ࣮ࣟࣅࢪࣙࣥ◊✲ᐊ㸧
どぬ◊✲㒊㛗 ゅ⏣࿴⦾
どぬ◊✲㒊࡛ࡣࠊどぬ࡟㛵ࡍࡿ⏕⌮Ꮫⓗ◊✲࠾ࡼࡧ║⑌ᝈ࡟㛵ࡍࡿᵝࠎ࡞ᇶ♏ⓗ࣭⮫ᗋⓗ
◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
どぬ⏕⌮Ꮫ◊✲ᐊ㸦ゅ⏣࿴⦾ᐊ㛗㸧࡛ࡣࠊᵝࠎ࡞࢖࣓࣮ࢪࣥࢢᢏ⾡㸦ගᖸ΅᩿ᒙィࠊ║ᗏ
⮬Ⓨ⺯ග㸧ࡸ㟁Ẽ⏕⌮Ꮫⓗ᳨ᰝ㸦⥙⭷㟁ᅗ㸧ࢆ⏝࠸࡚ࠊ⥙⭷ࡢ⏕⌮Ꮫⓗᶵ⬟ࢆᐈほⓗ࡟ホ౯
ࡍࡿ◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍࠋࡲࡓࠊᵝࠎ࡞㑇ఏᛶ⥙⭷⑌ᝈࡢヲ⣽࡞⑓ែࢆศᏊ㑇ఏᏛⓗ࡟ゎ᫂
ࡍࡿ࡭ࡃࠊ඲ᅜࡢ኱Ꮫࡸឤぬჾࢭࣥࢱ࣮ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊࡜ࡢඹྠ◊✲ࢆ⾜ࡗ࡚࠸ࡲ
ࡍࠋᮏᖺᗘࡼࡾ඲ᅜ୕༑ࡢ኱Ꮫࠊ◊✲ᶵ㛵ࡀཧ⏬ࡋࠊ኱つᶍඹྠ◊✲ࡀᮏ᱁ⓗ࡟ࢫࢱ࣮ࢺࡋ
ࡲࡋࡓࠋࡇࢀ࡟ࡼࡾࠊ㑇ఏᛶ⥙⭷⑌ᝈࡢ⑓ែࡢ⌮ゎࡀ᱁ẁ࡟῝ࡲࡿ࡜࡜ࡶ࡟ࠊ⮫ᗋ἞㦂࡟ྥ
ࡅࡓ‽ഛࢆᩚ࠼ࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋࡉࡽ࡟どぬ⏕⌮Ꮫ◊✲ᐊ࡛ࡣࠊ⡆౽࡞║ᗏ᧜ᙳ⿦⨨ࢆ㛤
Ⓨࡍࡿࡇ࡜࡛ᅾᏯࠊ㐲㝸ᆅ࡟࠾࠸࡚ࡶ㉁ࡢ㧗࠸║⛉デ⒪ࢆྍ⬟࡜ࡍࡿ ᐃࢩࢫࢸ࣒ࡢ㛤Ⓨ
࡟╔ᡭࡋࠊࣉࣟࢺࢱ࢖ࣉ⿦⨨ࢆ㛤Ⓨࡋ࡚࠾ࡾࡲࡍࠋ
࣮ࣟࣅࢪࣙࣥ◊✲ᐊ㸦㔝⏣ᚭᐊ㛗㸧࡛ࡣࠊ║ෆࣞࣥࢬᤄධ║ࡢ║ᗏどㄆᛶࢆホ౯ࡍࡿࡓ
ࡵࡢࣄࢺ║⌫ࣔࢹࣝࡢ㛤Ⓨࡸࠊ║ෆࣞࣥࢬࡀᤄධࡉࢀࡓ║⌫ࣔࢹࣝࢆ⏝࠸࡚ᐇ㝿࡟⥙⭷࡟
ᢞᙳࡉࢀࡿᫎീࡢ᧜ᙳࢆྍ⬟࡜ࡍࡿࢹࣂ࢖ࢫ㛤Ⓨ➼ࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
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ࠝどぬ⏕⌮Ꮫ◊✲ᐊࠞ
㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ⑕౛Ⓩ㘓ࢿࢵࢺ࣮࣡ࢡ
ゅ⏣࿴⦾
㸦どぬ◊✲㒊ࠊどぬ⏕⌮Ꮫ◊✲ᐊ㸧
せ⣙
඲ᅜࡢඹྠ◊✲᪋タ࠿ࡽ㞟ࡵࡽࢀࡓ㑇ఏᛶ⥙⭷ど⚄⤒⑌ᝈࡢ⾲⌧ᆺࠊ㑇ఏᏊᆺ࡟㛵ࡍࡿ
ࢹ࣮ࢱࢆ㞟✚ࡍࡿ඲ᅜึࡢ⑕౛Ⓩ㘓ࢩࢫࢸ࣒ࡀᵓ⠏ࡉࢀࡓࠋᖹᡂ 27 ᖺᗘᮎࡼࡾ㐠⏝ࡀ㛤ጞ
ࡉࢀࠊ௒ᚋࡢ἞⒪ᑟධࢆぢᤣ࠼ࡓᅜෆ࡟࠾ࡅࡿ኱つᶍࢥ࣮࣍ࢺࡢసᡂࠊ㑇ఏᏊᆺ⾲⌧ᆺ㛵㐃
ࢹ࣮ࢱ࣮࣋ࢫࡢసᡂ࡟࠾ࡅࡿᡂᯝࡀᮇᚅࡉࢀࡿࠋ
┠ⓗ
║⛉㡿ᇦ࡛ࡣ㑇ఏᏛⓗ࡞せᅉ࡟ࡼࡾ⥙⭷࠾ࡼࡧど⚄⤒࡟ኚᛶࢆ᮶ࡍ⑌ᝈࡀᩘከࡃᏑᅾࡍ
ࡿࠋࡇࢀࡽࡢ㑇ఏᛶ⥙⭷⑌ᝈࡣ㞴἞࡛࠶ࡾࠊඛ㐍ㅖᅜ࡛ࡣ୕኱୰㏵ኻ᫂ཎᅉࡢࡦ࡜ࡘ࡛࠶ࡿࠋ
ᝈ⪅ᩘࡣᮏ㑥࡛⣙ 5 ୓ேࠊୡ⏺࡛ࡣ⣙ 300 ୓ே࡜᥎ᐃࡉࢀࠊ௦⾲⑌ᝈ࡜ࡋ࡚ Stargardt ⑓
㸦ࢫࢱ࣮࢞ࣝࢺ⑓:STGD㸧ࠊ⥙⭷Ⰽ⣲ኚᛶ⑕(RP)ࠊ࣮ࣞ࣋ࣝඛኳ㯮ෆ㞀(LCA)ࠊ㯤ᩬࢪࢫࢺ
ࣟࣇ࢕(MD)ࠊ㗹య㸦ᮞయ㸧ࢪࢫࢺࣟࣇ࢕(CORD)➼ࡀᣲࡆࡽࢀࡿࠋ
୍㒊ࡢ⑌ᝈ࡟ࡘ࠸࡚ࡣḢ⡿ࢆ୰ᚰ࡟⸆≀⒪ἲࠊ㑇ఏᏊ἞⒪ࠊ෌⏕⣽⬊⛣᳜➼ࡢ⮫ᗋ἞㦂ࡀ
㛤ጞࡉࢀ࡚࠸ࡿࠋࡋ࠿ࡋᮏ㑥࡟࠾࠸࡚⮫ᗋ἞㦂ࢆྵࡵࡓ἞⒪ᑟධࡣ㐜ࢀ࡚࠾ࡾࠊࡇࢀࡣ⮫ᗋ
᳨ᰝࠊ㑇ఏᏊデ᩿ࣞ࣋ࣝ࡟࠾࠸࡚ᶆ‽໬ࡉࢀࡓデ᩿ᇶ‽࡟ᚑࡗࡓ἞⒪ᑐ㇟ࢥ࣮࣍ࢺసᡂࡀ
⾜ࢃࢀ࡚ࡇ࡞࠿ࡗࡓṔྐⓗ⫼ᬒ࡟㉳ᅉࡍࡿࠋ
ࡇࡢࡼ࠺࡞≧ἣࡢ୰ࠊ἞⒪ᑟධࢆぢᤣ࠼ࡓᅜෆ࡟࠾ࡅࡿ኱つᶍࢥ࣮࣍ࢺࡢసᡂࠊ㑇ఏᏊᆺ
⾲⌧ᆺ㛵㐃ࢹ࣮ࢱ࣮࣋ࢫࡢసᡂࡣ㔜せ࡞ㄢ㢟࡜࡞ࡗ࡚࠸ࡿࠋᙜ㝔࡛ࡣᩘᖺ๓࠿ࡽᅜෆࡢඹ
ྠ◊✲⤌⧊ࢆᣑ኱ࡋࠊᮏᖺᗘ࡟⮳ࡗ࡚඲ᅜ 30 వࡾࡢ኱Ꮫ◊✲ᶵ㛵ࢆ⤫ྜࡍࡿ⑌ᝈⓏ㘓ࢩࢫ
ࢸ࣒ࡀᵓ⠏ࡉࢀࡓࡢ࡛ࡇࡇ࡟⤂௓ࡍࡿࠋ
᪉ἲࠊ⤖ᯝ
ᅗ࡟⑕౛཰㞟ࡢࡓࡵࡢ⤌⧊ᅗࢆ♧ࡍࠋᮾி་⒪ࢭࣥࢱ࣮ࡢ⤫ᣓࡢୗࠊྛ⑌ᝈẖ࡟㈐௵⪅࡜
ࡋ࡚ࡢ⑌ᝈࢳ࣮࣒࣮ࣜࢲ࣮ࢆタࡅࡓ㸦ᅗ㸯㸧ࠋ⑌ᝈࢳ࣮࣒࣮ࣜࢲ࣮ࡢᙺ๭ࡣ௨ୗࡢ㏻ࡾ࡛࠶
ࡿࠋ
㸯㸧◊✲ィ⏬ࡢసᡂ࡜ࡋ࡚ࠊa ◊✲┠ⓗࠊデ᩿ᇶ‽ࠊࣜࢡ࣮ࣝࢺᇶ‽ࡢタᐃ㸦⑕౛ᩘࠊᐙ᪘
᥇⾑ࡢᚲせᛶࠊ࢔ࢵࣉ࣮ࣟࢻࡀᚲせ࡞᳨ᰝ㡯┠➼ࢆྵࡵࡿ㸧
ࠊb 㑇ఏᏊゎᯒࡢὶࢀࢆỴࡵࡿࠋ
㸦ࢲ࢖ࣞࢡࢺࢩ࣮ࢡ࢚ࣥࢫࠊExomeࠊከ᪋タ࡜ࡢඹྠ◊✲➼㸧ࠊc ඹྠ◊✲⪅࡟ୖグࢆศ࠿
ࡾࡸࡍࡃᗈሗࡋࠊ᳨యࡢ཰㞟࡟ດࡵࡿࠋ
㸰㸧࢔ࢵࣉ࣮ࣟࢻࡉࢀࡓ⑕౛ࡢࢹ࣮ࢱ☜ㄆ࡜ࡋ࡚ࠊ a Ⓩ㘓⑕౛ࡀࣜࢡ࣮ࣝࢺᇶ‽ࢆ‶ࡓࡋ
ࡓ࡚࠸ࡿ࠿㸽 bࠊ⑌ᝈศ㢮ࡣṇࡋ࠸࠿ࠋ cࠊ࢚ࢡࢯ࣮࣒ゎᯒ࡟ᚲせ࡞ᐙ᪘᥇⾑ࡀ⾜ࢃࢀ࡚
࠸ࡿ࠿㸽 ➼ࡢ᳨ドࢆ⾜࠺ࠋ
― 32 ―
㸦ᅗ㸯㸧
᪂つⓏ㘓ࢩࢫࢸ࣒࡛ࡣࠊ࠶ࡽࡺࡿ㑇ఏᛶ⑌ᝈ࡟ᑐᛂ࡛ࡁࡿࡼ࠺࡟ࠊᑐ㇟⑌ᝈࢆ 56 ศ㢮࡟
ᗈࡆࠊࡉࡽ࡟㑇ఏᏊᆺࢆ㔜どࡋࡓศ㢮ἲ࡜ࡋࡓ㸦ᅗ㸰㸧ࠋ
㸦ᅗ㸰㸧
⑕౛Ⓩ㘓ࠊ᳨యᥦฟ࠿ࡽ⤖ᯝᥦ♧ࡲ࡛ࡢὶࢀࢆࠊࢩࢫࢸ࣐ࢸ࢕ࢵࢡ࡟ᵓ⠏ࡋࡓ㸦ᅗ㸱㸧ࠋ
ྛ⑌ᝈࢳ࣮࣒࣮ࣜࢲ࣮ࡣࠊࡑࢀࡒࢀࡀ❧᱌ࡋࡓ⑕౛ࣜࢡ࣮ࣝࢺࣉࣛࣥ࡟ᇶ࡙ࡁࠊྛ᪋タ࡟
― 33 ―
⑕౛Ⓩ㘓ࢆ࿧ࡧ࠿ࡅࡿࠋᖹᡂ 27 ᖺᗘ⌧ᅾࠊ≉࡟㔜どࡋ࡚ࣜࢡ࣮ࣝࢺࢆ⾜࠺ࣉࣛࣥࡣ௨ୗࡢ
㏻ࡾ࡛࠶ࡿࠋ
ձ ⥙⭷Ⰽ⣲ኚᛶࠊLCA
ղ ࢜࢝ࣝࢺ㯤ᩬࢪࢫࢺࣟࣇ࢕㸦୕Ꮿ⑓㸧ࣉࣟࢪ࢙ࢡࢺ
㸨 RP1L1 ኚ␗⑕౛ 30 ౛௨ୖࡢኚ␗࣭⾲⌧ᆺ࡟ࡘ࡚ࡢሗ࿌
㸨 AR࣭OMD ࡢཎᅉ㑇ఏᏊࡢ᥈⣴
㸨 RP1L1 ኚ␗࡟ࡼࡗ࡚⏕ࡌࡿ OMD ௨እࡢ⾲⌧ᆺ
ճ ᮞయ୍ⰍぬࠊAchromatopsia
㸨 」ᩘࡢ᪂つ㑇ఏᏊኚ␗ࡀ㛵୚ࡢྍ⬟ᛶ
ࡇࡢ࠺ࡕ㑇ఏᏊ A ࡟ࡘ࠸࡚ࡣࠊከ◊✲᪋タ࡟ᶵ⬟ゎᯒࢆ౫㢗୰
մ ࢫࢱ࣮࢞ࣝࢺ⑓
㸨 㑇ఏᏊ἞⒪ᑟධࢆぢᤣ࠼ࡓ᪥ᮏே Stargardt ⑓ࡢ኱ࢥ࣮࣍ࢺసᡂ
⌧ᅾࠊ20 ᩘ᳨యࡀࢥࣟࣥࣅ࢔኱Ꮫ࡟࡚ゎᯒ୰
յ ຎᛶ BestrophinopathyࠊARB
㸨 ᪥ᮏ࡛ሗ࿌ࡢ↓࠿ࡗࡓ ARB ࡢ⑕౛࡟ࡘࡁࠊྡ኱ࢆ୰ᚰ࡟ኚ␗࣭⾲⌧ᆺࡢሗ࿌
ն ᏶඲ᆺඛኳ೵Ṇᛶኪ┣
㸨 AR ᐙ⣔࡟᪂つ㑇ఏᏊ B ࡀ㛵୚ࡢྍ⬟ᛶ
ᾏእඹྠ◊✲᪋タ࡜㑇ఏ᝟ሗࢆඹ᭷ࡋࠊᶵ⬟ゎᯒࢆ౫㢗ணᐃࠋ
շ ࣮ࣞ࣋ࣝど⚄⤒⑕
㸨 ࣑ࢺࢥࣥࢻࣜ࢔ DNA ࡟ኚ␗ࢆᣢࡘᐙ⣔ࢆᑐ㇟࡟ࠊX ᰁⰍయࡢ㛵୚ࢆ࢚ࢡࢯ࣮࣒࡟
ࡼࡾゎ᫂ࡍࡿࠋ
㸦ᅗ㸱㸧
ゎᯒ⤖ᯝ࡟ࡘ࠸࡚ࡣࠊᐙ⣔ෆ Segregation ࡀ⤊஢ࡋࡓࡶࡢ࠿ࡽྛࢳ࣮࣒࣮ࣜࢲ࣮ࢆ㏻ࡌ
― 34 ―
࡚୺἞་࡟㏻▱ࡉࢀࡿࠋ⑌ᝈ㛵㐃ኚ␗ࢆ♧ࡍሗ࿌ࢩ࣮ࢺࡀసᡂࡉࢀࠊࡇࢀ࡟ࡣ⑌ᝈ࡜ࡢ㛵ಀ
ࡀᙉ࠸ Major mutationࠊ࠾ࡼࡧᙉࡃࡣ࡞࠸ࡀ㛵୚ࡀ␲ࢃࢀࡿ Minor mutation ➼ࡀࣜࢫࢺ
࢔ࢵࣉࡉࢀ࡚࠸ࡿ㸦ᅗ㸲㸧ࠋ
㸦ᅗ㸲㸧
Ⓩ㘓ࢩࢫࢸ࣒ࡢ࡞࠿࡛ࠊඹྠ◊✲⪅ࡀ⌧ᅾⓏ㘓ࡉࢀ࡚࠸ࡿ⑕౛ࡢᴫせࢆ㜀ぴࡍࡿࡇ࡜ࡀ
࡛ࡁࡿࠋࡇࢀ࡟ࡣᐙ⣔ᅗࠊ⑕≧⤒㐣ࡢ࡯࠿ࠊ║ᗏࠊOCT ➼ࡢ⏬ീࡶྵࡲࢀࠊࡦ࡜ࡘࡢࣇ࢓
࢖ࣝ࡜ࡋ࡚⡆༢࡟⑓ែࢆᢕᥱࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㜀ぴࣇ࢓࢖ࣝࡢ୍㒊ࢆ㸦ᅗ㸳ࠊ㸴㸧࡟♧ࡍࠋ
㸦ᅗ㸳㸧⑕౛᝟ሗࣜࢫࢺࡢ୍㒊
― 35 ―
㸦ᅗ㸴㸧⏬ീࣜࢫࢺࡢ୍㒊
⤖ㄽ
ᮏᖺᗘ࠿ࡽᵓ⠏ࢆ㛤ጞࡋࡓ᪂つⓏ㘓ࢩࢫࢸ࣒ࡀࠊᮏᖺ 3 ᭶࡟ࡼ࠺ࡸࡃ㐠⏝㛤ጞࡉࢀࡿࡇ
࡜࡟࡞ࡗࡓࠋࡇࢀ࡟ࡼࡾࠊᕼᑡ⑌ᝈࡢ⑌ᝈ᝟ሗࠊ㑇ఏ᝟ሗࡀຠ⋡ࡼࡃࠊ࠿ࡘ኱つᶍ࡟㞟✚ࡉ
ࢀࠊ᪥ᮏே࡟࠾ࡅࡿ⥙⭷ど⚄⤒⑌ᝈࡢ㑇ఏᆺ⾲⌧ᆺࡢᤸᥱࡀ᪩ᮇ࡟ᐇ⌧ࡉࢀࡿࡇ࡜ࡀᮇᚅ
ࡉࢀࡿࠋ
― 36 ―
࣮ࠝࣟࣅࢪࣙࣥ◊✲ᐊࠞ
᪂ࡓ࡞㧗⢭ᗘ║ෆࣞࣥࢬᗘᩘィ⟬⌮ㄽᘧࡢ㛤Ⓨ
㔝⏣ᚭࠊ኱἟୍ᙪ
㸦どぬ◊✲㒊ࠊ࣮ࣟࣅࢪࣙࣥ◊✲ᐊ㸧
せ⣙
᪂ࡓ࡞║ෆࣞࣥࢬᗘᩘィ⟬ᘧࢆࠋ
┠ⓗ
ᮏ◊✲ࡣࠊゅ⭷࠾ࡼࡧ║ෆࣞࣥࢬࡢཌࡳࢆ⪃៖ࡋࡓ㧗⢭ᗘ࡞║ෆࣞࣥࢬᗘᩘィ⟬⌮ㄽᘧ
ࡢᥦ᱌ࢆ┠ⓗ࡜ࡍࡿࠋࡇࢀࡲ࡛ࡣ⾡๓࡟⾡ᚋࡢ║ෆࣞࣥࢬࡢ఩⨨ࢆṇ☜࡟᥎ᐃࡍࡿࡇ࡜ࡣ
ᅔ㞴࡜ࡉࢀࠊࡑࢀࢆᵝࠎ࡞ィ ್࠿ࡽ᥎ᐃࡍࡿィ⟬ᘧࡀᥦ᱌ࡉࢀ࡚ࡁࡓࠋࡋ࠿ࡋࠊᚑ᮶ࡢ║
ෆࣞࣥࢬࡢᗘᩘィ⟬ᘧࡢከࡃࡣゅ⭷๓㠃᭤⋡࠾ࡼࡧ║㍈㛗ࡢ್࠿ࡽᗘᩘࡢ⟬ฟࢆࡍࡿࡶࡢ
ࡀከࡃࠊࡑࢀࡽࡣࠊࣞࣥࢬࡢཌࡳࢆ⪃៖ࡏࡎ⢭ᗘࡀప࠸ࠊゅ⭷๓㠃࡜ᚋ㠃᭤⋡ࢆ୍ᐃẚ⋡࡜
ࡍࡿࡓࡵᒅᢡ▹ṇᡭ⾡║࡛ࡣㄗᕪࡀ኱ࡁࡃ࡞ࡿࠊゅ⭷๓㠃ᒅᢡ್ࡀ║ෆࣞࣥࢬ఩⨨ࡢ᥎ᐃ
࡟ㄗᕪࢆ⏕ࡌࡿࠊ࡞࡝ࡢၥ㢟࡟ࡼࡾィ⟬⢭ᗘࡣ㝈ࡽࢀ࡚࠸ࡓࠋࢃࢀࢃࢀࡣࠊ㏆ᖺ᪂ࡓ࡟㛤Ⓨ
ࡉࢀࡓ๓║㒊 OCT ࡟ࡼࡾ⾡๓࡟᧜ᙳࡉࢀࡓ๓║㒊⏬ീ᝟ሗ࠿ࡽ⾡ᚋࡢ║ෆࣞࣥࢬ఩⨨ࢆ㧗
࠸⢭ᗘ࡛ண ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡇ࡜ࢆ๓ᥦ࡟ࠊࡑࡢ║ෆࣞࣥࢬ఩⨨᝟ሗࢆ⏝࠸ࠊゅ⭷ࠊ║ෆ
ࣞࣥࢬࡢཌࡳࢆ⪃៖ࡋࡓࡓࡼࡾ⢭ᗘࡢ㧗࠸║ෆࣞࣥࢬィ⟬⌮ㄽᘧࡢᥦ᱌ࡋࠊࡑࡢ᭷⏝ᛶࢆ
᳨ドࡍࡿࠋ
᪉ἲ
࠙㸯ࠚ᪂ࡓ࡞║ෆࣞࣥࢬィ⟬ᘧࡢ⟇ᐃ
ᅗ㸯 ║ගᏛ⣔࡟࠾ࡅࡿࢫࢿࣝࡢἲ๎࡟ᇶ࡙ࡃග⥺㏣㊧ἲ
― 37 ―
― 38 ―
― 39 ―
― 40 ―
― 41 ―
― 42 ―
㻌
㻌
㻌
㻌
⫈ぬ䞉ᖹ⾮ぬ◊✲㒊㻌
㻌
㒊㛗㻌 㻌 㻌 ⸨஭㻌 ṇே㻌
㻌
⫈ぬ㞀ᐖ◊✲ᐊ㻌
ᯇỌ㻌 㐩㞝㻌 ᐊ㛗㻌
ᖹ⾮ぬ㞀ᐖ◊✲ᐊ㻌
஬ᓥ㻌 ྐ⾜㻌 ᐊ㛗㻌
෌⏕་⒪◊✲ᐊ㻌 㻌 㻌 㻌 㻌 ⴠྜ㻌 ༤Ꮚ㻌 ᐊ㛗㻌
ࠝ⫈ぬᖹ⾮ぬ◊✲㒊ࠞ ⫈ぬᖹ⾮ぬ◊✲㒊 㒊㛗
⸨஭ṇே
ᮏᖺࡣࠊ1+2 ࢿࢵࢺ࣮࣡ࢡ◊✲࠙ឤぬჾࠚඹྠ◊✲ࠊ࠾ࡼࡧ㞴⫈㑇ఏᏊࡢ◊✲ࡶ࠸ࡃࡘ࠿
ࡢࣉࣟࢪ࢙ࢡࢺ࡛㐍⾜ࡋ࡚࠸ࡿࠋ◊✲ဨ࡟ࡼࡿᇶ♏ⓗ◊✲࡛ࡣࠊㄽᩥࡶᥖ㍕ࡉࢀᐇ⦼ࡀୖ
ࡀࡗ࡚ࡁ࡚࠸ࡿࠋ୍᪉ࠊ㢌㢕㒊⒴࡟ᑐࡍࡿᇶ♏◊✲࡜ከ᪋タඹྠ◊✲ࡸࠊ෌⏕་⒪◊✲ᐊ
ࡢ⒕⑞◊✲ࡶ⾜ࢃࢀ࡚࠸ࡿࠋ
⫈ぬ㞀ᐖ◊✲ᐊ㛗 ᯇỌ㐩㞝
௒ᖺᗘࡣ࢚ࢡࢯ࣮࣒ゎᯒ࡜࠸࠺᪉ἲࢆ⏝࠸ࡓࣄࢺ඲㑇ఏᏊࡢゎᯒࢆ୰ᚰ࡟㐍ࡵࡓࠋᴟࡵ
࡚⭾኱࡞᝟ሗ㔞ࡢࢹ࣮ࢱࢆᢅ࠺ࡓࡵ࡟ࠊ࠶ࡽࡺࡿഃ㠃࡛ከ኱࡞ປຊࢆせࡋࡓࡀࠊṇ☜࡟ゎ
ᯒ࡛ࡁࡿὶࢀࢆ☜❧࡛ࡁࡓࠋࡇࢀ࡟ࡼࡾ᪂ࡓ࡞㞴⫈ᐙ⣔ࡢゎᯒࢆࠊ୙Ᏻ࡞ࡃࠊ㐜ࢀ࡞ࡃࠊ
ุᐃࢆୗࡏࡿయไࢆᩚ࠼ࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡇࡢ⤖ᯝࠊ᪂つࡢ㞴⫈࠶ࡿ࠸ࡣ᪂つࡢ㞴⫈ཎᅉ
㑇ఏᏊࡢೃ⿵ࢆḟࠎ࡜Ⓨぢࡀ⥆࠸࡚࠸ࡿࠋࡑࡢ་Ꮫ⏕≀Ꮫⓗ᳨ドࡢࡓࡵࡢࠊ⣽⬊ࠊື≀ᐇ
㦂ࡶ㐍ࡳࠊ☜ドࡀᚓࡽࢀࡘࡘ࠶ࡿࠋࡉࡽ࡟ࠊ᪂ࡓ࡞἞⒪ἲ㛤Ⓨࡢ◊✲࡜ࡋ࡚ࠊ៞ᛂ⩏ሿ኱
Ꮫ࡜ඹྠ࡛ Pendred ⑕ೃ⩌࡟ᑐࡍࡿ἞㦂ᐇ᪋࡟ྥࡅࡓ‽ഛࢆ㐍ࡵࡓࠋࡑࡢࡓࡵࡢᇶ♏᝟ሗ
࡜ࡋ࡚ࡢࠊᮏ㞴⫈ᝈ⪅ࡢከᩘ౛࡟ࡘ࠸࡚ࠊ㛗ᮇ࡟ࢃࡓࡿ⫈ຊ⤒㐣ࡢゎᯒࢆ㐍ࡵࡓࠋ
≉ᚩⓗ࡞⫈ຊᅗ㸦࣮࢜ࢪ࢜ࢢ࣒ࣛ㸧ࢆ࿊ࡍࡿ㞴⫈⪅࡟࠾ࡅࡿࠊ≉ᐃࡢ㞴⫈㑇ఏᏊࡢ㛵୚
ࢆ᳨ウࡋࡓࠋලయⓗ࡟ࡣ㇂ᆺ㸦୰㡢ᇦ㞀ᐖ㸧ࠊప㡢㞀ᐖᆺ㸦ప㡢ᇦ㞀ᐖ㸧ࠊ㧗㡢㞀ᐖᆺ㸦㧗
㡢ᇦ㞀ᐖ㸧ࡢ㞴⫈⪅࡟࠾࠸࡚ࠊࡑࢀࡒࢀ TECTA 㑇ఏᏊࠊWFS1 㑇ఏᏊࠊCDH23 㑇ఏᏊࡢ
ኚ␗ࢆゎᯒࡋࡓࠋࡇࡢ⤖ᯝࠊࡑࢀࡒࢀ୍ᐃࡢ㢖ᗘ࡛ྠᐃࡉࢀࡿࡇ࡜ࡀุ᫂ࡋࠊࡇࢀࡽࡢ㞴
⫈ᝈ⪅ࡢ⑓ែࡢண ࠊ㑇ఏᏊ᳨ᰝࡢጇᙜᛶࠊ㑇ఏᏊ᳨ᰝ๓࡟ᝈ⪅࡟ཎᅉࡀุ᫂ࡍࡿྍ⬟ᛶ
࡟ࡘ࠸࡚ࡢㄝ᫂࡟ά⏝ྍ⬟࡜࡞ࡗࡓࠋࡲࡓࠊᑠඣ㞴⫈඲య࡟࠾ࡅࡿ IP-III ᆺࡢෆ⪥ወᙧࡢ
㢖ᗘ࡜ࠊᮏෆ⪥ወᙧࢆᣢࡘ㞴⫈⪅࡟࠾ࡅࡿ POU3F4 㑇ఏᏊ
ࡢኚ␗ࢆゎᯒࡋ࡚ࠊᮏෆ⪥ወᙧࡢ㢖ᗘࡣ㠀ᖖ࡟ప࠸ࡀࠊᮏෆ⪥ወᙧࢆ᭷ࡍࡿ㞴⫈⪅࡛ࡣ඲
౛࡟ POU3F4 㑇ఏᏊࡢኚ␗ࡀྠᐃࡉࢀࡿࡇ࡜ࡀุ᫂ࡋࡓࠋࡲࡓࠊᮏෆ⪥ወᙧ࡛ࡣ๓ᗞỈ⟶
ᣑ኱ࢆ඲౛࡟ㄆࡵࠊࡑࡢ≉ᚩ࡜ࡋ࡚ෆ⪥ഃࡢᣑ኱ࡀ㢧ⴭ࡛࠶ࡾࠊ୰㢌⵹❐ഃࡢᣑ኱ࢆㄆࡵ
ࡿ Pendred ⑕ೃ⩌/DFNB4 ࡜␗࡞ࡿࡇ࡜ࢆึࡵ࡚☜ㄆ࡛ࡁࡓࠋࡇࡢᙧែⓗ≉ᚩࡀࠊᮏ㞴⫈
࡛ࡣ㐍⾜ࠊኚືࢆ࿊ࡉ࡞࠸ཎᅉ࡛࠶ࡿ࡜᥎ ࡉࢀࡓࠋࡇࢀࡽࡢ⤖ᯝ࠿ࡽࠊෆ⪥ወᙧࡢ␿Ꮫ
᝟ሗࠊ㑇ఏᏊ᳨ᰝࡢ㐺ᛂุ᩿ࠊ⑓ែ࡜ணᚋࡢ᥎ ࢆྥୖ࡛ࡁࡓࠋ
ᖹ⾮ぬ㞀ᐖ◊✲ᐊᐊ㛗 ஬ᓥྐ⾜
௒ᖺᗘࡣᖺ㛫⣙ 250 ྡࡢ㞴἞ᛶࡵࡲ࠸ᝈ⪅࡟ᑐࡋ࡚ධ㝔ࡢୖ㞟ᅋࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ἞⒪
― 43 ―
ࢆ⾜ࡗࡓࠋ⾲ᅾឤぬ࠾ࡼࡧయᛶឤぬ᳨ᰝࢆᑟධࡋࠊ᪂ࡋ࠸ࡵࡲ࠸ࡢ⑌ᝈᴫᛕ࡜ࡋ࡚ࡢయᛶ
ឤぬࡵࡲ࠸ࡢ◊✲ࢆ⾜ࡗࡓࠋࡲࡓႥぬㄆ▱ᶵ⬟࡜ᖹ⾮ᶵ⬟࡜ࡢ㛵ಀ࡟ࡘ࠸᳨࡚ウࢆ⾜ࡗࡓࠋ
࠶ࡓࡽࡋ࠸἞⒪ᡭẁ࡜ࡋ࡚㞴἞ᛶ∦ഃ๓ᗞ㞀ᐖ௦ൾ୙඲ᝈ⪅࡟ᑐࡋ࡚ tDCS(┤ὶ㟁Ẽ่⃭)
࡟ࡼࡿᖹ⾮ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࡢቑᙉຠᯝ࡟ࡘ࠸࡚ி㒔኱Ꮫ࡜ඹྠ◊✲ࢆ⾜ࡗࡓࠋࡲࡓᮥ
ᯘ኱Ꮫ⢭⚄⛉࡜ࡢඹྠ◊✲࡛ rTMS(☢Ẽ่⃭)࡟ࡼࡿ἞⒪◊✲ࡶ⾜ࡗࡓ㸦⌧ᅾᢞ✏୰㸧ࠋ
ᖇி኱Ꮫබ⾗⾨⏕Ꮫᩍᐊ࡜ࡢඹྠ◊✲࡛ࡵࡲ࠸ࡢ㞴἞໬ࡢᚰ⌮♫఍ⓗᐜ᫆࡟ࡘ࠸࡚⤫ィᏛ
ⓗᡭἲࢆ⏝࠸࡚᫂ࡽ࠿࡟ࡋࡓࠋ
෌⏕་⒪◊✲ᐊᐊ㛗 ⴠྜ༤Ꮚ
ᙜ◊✲ᐊࡣࠊᙧᡂእ⛉㡿ᇦ࡛ࡢ⮫ᗋᛂ⏝ࢆ┠ᣦࡋࡓ◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ㏆ᖺࡣࠊᙧᡂእ⛉࣭
ᩚᙧእ⛉㡿ᇦ࡟࠾࠸࡚౑⏝㢖ᗘࡀ㧗࠸ேᕤ㦵࡟㛵ࡍࡿື≀ᐇ㦂ࢆ⾜ࡗࡓࠋḟୡ௦ேᕤ㦵࡜
ࡋ࡚ࠊ⏕య㦵࡟㏆࠸⤌ᡂࢆᣢࡗࡓࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃࢱ࢖ࢺ㸭ࢥ࣮ࣛࢤࣥ」ྜయ㸦௨ୗ HA/Col㸧
ࡀᐇ⏝໬ࡉࢀࡓࡀࠊ㢌⵹㡿ᇦ࡛ࡢᏳ඲ᛶ࣭᭷ຠᛶࡣド᫂ࡉࢀ࡚࠸࡞࠸ࠋ⚾ࡓࡕࡣࠊࣛࢵࢺ
㢌㡬㦵࡟ HA/Col ேᕤ㦵ࢆ⛣᳜ࡋࠊࡑࡢ㦵⒵ྜࢆ⤌⧊Ꮫⓗ࡟᳨ウࡋࠊ᭷ຠᛶࢆ᳨ウࡋࡓࠋࡲ
ࡓࠊ㦵㧊⏤᮶㛫ⴥ⣔ᖿ⣽⬊࡟ࡼࡿ⓶⭵⒕⑞ᙧᡂᢚไ◊✲ࡣࠊᅜ❧ᡂ⫱་⒪◊✲ࢭࣥࢱ࣮࡜
ࡢඹྠ◊✲࡛⮫ᗋᛂ⏝ࡀᐇ᪋ࡉࢀ࡚࠾ࡾࠊ௒ᚋࡣ௚ࡢ⣽⬊㸦MUSE ⣽⬊࡞࡝㸧࡟ࡼࡿ⒕⑞
ᢚไຠᯝࡶ᳨ドணᐃ࡛࠶ࡿࠋ
― 44 ―
ࠝ⫈ぬ㞀ᐖ◊✲ᐊࠞ
࣮࣡ࣝࢹࣥࣈࣝࢢ⑕ೃ⩌Ϩᆺࡢ᪂ࡓ࡞㑇ఏⓗཎᅉࡢ᳨ウ
ᯇỌ㐩㞝ࠊົྎⱥᶞࠊ㞴Ἴ୍ᚨ
㸦⫈ぬ㞀ᐖ◊✲ᐊ㸧
せ ⣙
⮫ᗋᡤぢ࠿ࡽࡣ :6 ࡜デ᩿ࡉࢀࡓᝈ⪅࠿ࡽ 3$; 㑇ఏᏊ࡟␗ᖖࡀ࡞ࡃࠊ('15% 㑇ఏᏊࡢ࣑
ࢫࢭࣥࢫኚ␗࣍ࣔ᥋ྜయࡀㄆࡵࡽࢀࡓࠋࡇࡢࡇ࡜ࡼࡾࠊ:6 ࡢ୍㒊ࡢᝈ⪅ࡀ ('15% 㑇ఏᏊࡢ
≉ᐃࡢኚ␗ࡢຎᛶ㑇ఏ࡜ࡋ࡚Ⓨ⑕ࡍࡿྍ⬟ᛶࡀ♧ࡉࢀࡓࠋᮏᐙ⣔࡛ㄆࡵࡽࢀࡓ ('15% 㑇ఏ
Ꮚኚ␗ࡣ +LUVFKVSUXQJ ⑓ࡢཎᅉ㑇ఏᏊ࡜ࡉࢀ࡚࠸ࡿࡀࠊᮏᐙ⣔࡛ࡣ +LUVFKVSUXQJ ⑓ࡣⓎ
⑕ࡏࡎࠊࡇࢀࡣᮏ⑌ᝈࡀከᅉᏊ㑇ఏ࡛࠶ࡿࡓࡵ࡜⪃࠼ࡽࢀࡓࠋ
┠ ⓗ
࣮࣡ࣝࢹࣥࣈࣝࢢ⑕ೃ⩌:6ࡣ⚄⤒ሐ⣽⬊ࡢⓎ⏕␗ᖖ࡟ࡼࡾឤ㡢㞴⫈࡜ⓑ㧥ࠊ⹿ᙬ␗Ⰽ
⑕ࠊ⓶⭵ࡢⓑᩬ࡞࡝ࡢⰍ⣲␗ᖖࢆ୺⑕≧࡜ࡍࡿᖖᰁⰍయඃᛶ㑇ఏ㸦$'㸧࠶ࡿ࠸ࡣᖖᰁⰍయ
ຎᛶ㑇ఏ㸦$5㸧ࡢ⑌ᝈ࡛࠶ࡿࠋ⮫ᗋ⑕≧࠿ࡽ :6 ᆺ࡟ศ㢮ࡉࢀࠊࡇࢀࡲ࡛࡟ ✀㢮ࡢཎ
ᅉ㑇ఏᏊࡀྠᐃࡉࢀ࡚࠸ࡿ㸦⾲㸧
ࠋ:6 ࡣෆ║ゅ஋㞳ࡀ࠶ࡾࠊ࡯ࡰ඲౛ࡀ 3$; 㑇ఏᏊኚ␗㸦$'㸧
࡛Ⓨ⑕ࡍࡿࠋ:6 ࡣෆ║ゅ஋㞳ࡣ࡞ࡃࠊ:6 ࡣ :6 ࡟ᅄ⫥ࡢወᙧࡀຍࢃࡾࠊ:6 ࡣ :6 ࡟
+LUVFKVSUXQJ ⑓ࢆక࠺ࠋ('15% ኚ␗ࡲࡓࡣ ('1 ኚ␗ࡣࡇࢀࡲ࡛࡟ :6 ࡢ 㸫㸣࡟ $' ࠶
ࡿ࠸ࡣ $5 ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠾ࡾࠊ:6 ࡢࡈࡃ୍㒊࡛ࡶ୙᏶඲ᾐ㏱ࡢ $' ࡜ࡋ࡚ሗ࿌ࡀ࠶ࡿࠋ
௒ᅇࠊ⮫ᗋⓗ࡟ࡣ :6 ᆺ࡜デ᩿ࡉࢀࡓඣ࡟ᑐࡋ࡚ 3$; ௨እࡢ㑇ఏⓗཎᅉࡢゎ᫂ࢆ⾜ࡗࡓࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
㛗ዪࡣ೺⫈ࠊẕ᪉ࡢ᭮♽ẕࡣ㞴⫈㸦ヲ⣽୙᫂㸧࡛࠶ࡗࡓࠋ ṓዪඣࠊ኱ࡁ࡞㡢࡟཯ᛂࡋ࡞
࠸ࡇ࡜࡟୧ぶࡀẼ௜ࡁࠊ㞴⫈ࡀ␲ࢃࢀ࡚ᙜ㝔ཷデࡋࡓࠋ$%5 ࡛ࡣ FOLFN 㡢࡟ࡼࡾ G% ࡛୧
ഃ཯ᛂࢆㄆࡵࡎࠊ$665 ࡛ࡣྑ G%ࠊᕥ G% ࡜㜈್ࡀୖ᪼ࠊ⣧㡢⫈ຊ᳨ᰝ࡟࡚୧ഃ G%
࡛࠶ࡗࡓࠋ୧ഃࡢ⹿ᙬࡀ㟷ࡃࠊෆ║ゅ஋㞳ࡀㄆࡵࡽࢀࡓ:LQGH[㸸㸦㸼㸧ࠋࡲࡓࠊ
㰯᰿㒊ࡀ┠❧ࡗࡓࡀࠊⓑ㧥ࡣㄆࡵ࡞࠿ࡗࡓࠋ║⛉᳨ᰝ࡛ࡣ୍ഃ୙ྠど࡜ᙅどࡀㄆࡵࡽࢀࡓࠋ
ᅄ⫥ࡢወᙧࠊ⭠⟶㐠ື␗ᖖࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࠋഃ㢌㦵 &7 ࡛ࡣෆ⪥ወᙧࢆㄆࡵ࡞࠿ࡗࡓࠋ
௨ୖࡢᡤぢ࠿ࡽ :6 ᆺ࡜デ᩿ࡉࢀࡓࠋ▱ⓗⓎ㐩ࡣᖺ㱋┦ᙜ࡛࠶ࡾࠊ ṓ᫬࡟ྑேᕤෆ⪥␃⨨
⾡ࢆ᪋⾜ࡋࡓࡀゝㄒⓎ㐩ࡶ㡰ㄪ࡛࠶ࡿࠋ୧ぶ࡜඗ࠊ࠾ࡼࡧ௚ࡢぶ㢮࡟ࡣ :6 ࡢ⑕≧ࡣ࡞࠿ࡗ
ࡓࠋ㑇ఏᏊゎᯒࡣᮎᲈ⾑ '1$ ࡢࢧ࣮ࣥ࢞ἲ࡟ࡼࡿ᳨ᰝ࡛⾜ࡗࡓࠋ
― 45 ―
⤖ ᯝ
ዪඣ࠿ࡽࡣ ('15% 㑇ఏᏊ࣑ࢫࢭࣥࢫኚ␗ࡢ࣍ࣔ᥋ྜయࡀㄆࡵࡽࢀࡓࠋࡲࡓࠊ୧ぶ࡟ࡣྠ
㑇ఏᏊኚ␗ࡢ࣊ࢸࣟ᥋ྜయࡀࡑࢀࡒࢀㄆࡵࡽࢀࡓࠋ3$; 㑇ఏᏊࠊ0,7) 㑇ఏᏊࠊ62; 㑇ఏ
Ꮚ࡟ኚ␗ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࠋᮏ⑕౛ࡣࠊ⮫ᗋⓗ࡟ࡣෆ║ゅ஋㞳ࡀࡳࡽࢀࡿ௚ࡣ :6 ࡢࢧࣈ
ࢱ࢖ࣉ࡟≉ᚩⓗ࡞ᡤぢࡶ࡞ࡃࠊ:6 ࡜デ᩿ࡉࢀࡓࠋࡋ࠿ࡋ㑇ఏᏊゎᯒ࡛ࡣࠊࡇࢀࡲ࡛࡟ :6
࡛ࡢሗ࿌ࡀ࡞࠸ ('15% 㑇ఏᏊኚ␗ࡢ࣍ࣔ᥋ྜయࡀㄆࡵࡽࢀࡓࠋࡇࡢࡓࡵࠊ㑇ఏᏊゎᯒ⤖ᯝ
࡜⮫ᗋᡤぢࡢ㛵㐃࡟ࡘ࠸᳨࡚ウࡋࡓࠋ
ࡲࡎ ('15% 㑇ఏᏊኚ␗ࡢᖖᰁⰍయຎᛶ㑇ఏᙧᘧ㸦$5㸧࡟ࡼࡿ :6 ࡜ࡋ࡚ࡢ᳨ウࢆ⾜ࡗࡓࠋ
:6 ࡣ 㸣௨ୖ࡟ 3$; 㑇ఏᏊኚ␗ࡀㄆࡵࡽࢀ࡚࠾ࡾࠊࡍ࡛࡟ ㏆࠸ኚ␗ࡀሗ࿌ࡉࢀ࡚࠸
ࡿࠋᮏ⑕౛ࡣ 3$; ࡢ㑇ఏᏊゎᯒ࡛ࡇࢀࡽࡢኚ␗ࢆㄆࡵ࡞࠿ࡗࡓࡶࡢࡢࠊ:6 ࡢ⮫ᗋ⑕≧ࢆ
࿊ࡋࡓࡇ࡜࠿ࡽࠊ:6 ࡢࡈࡃ୍㒊ࡢ⑕౛࡟ ('15% 㑇ఏᏊኚ␗ࡢຎᛶ㑇ఏࡀྵࡲࢀ࡚࠸ࡿྍ⬟
ᛶࡀ♧၀ࡉࢀࡓࠋ
ḟ ࠸ ࡛ ྠ ୍ ࡢ ('15% ኚ ␗ ࢔ ࣞ ࣝ ࡢ ࣊ ࢸ ࣟ ᥋ ྜ య ࡜ ࣍ ࣔ ᥋ ྜ య ࡟ ࡼ ࡿ :6 ࠾ ࡼ ࡧ
+LUVFKVSUXQJ ⑓ࡢⓎ⑕࡜㠀Ⓨ⑕ࡢ᳨ウࢆ⾜ࡗࡓࠋᮏᐙ⣔࡛ྠᐃࡉࢀࡓ ('15% 㑇ఏᏊࡢ࣑ࢫ
ࢭࣥࢫኚ␗ࡣ࣊ࢸࣟ᥋ྜయ࡜ࡋ࡚ +LUVFKVSUXQJ ⑓ࢆ༢⊂࡛࿊ࡋࡓᝈ⪅࡛ሗ࿌ࡉࢀ࡚࠸ࡿࠋ
ࡋ࠿ࡋࠊᮏᐙ⣔࡛ࡣࡇࡢኚ␗ࡢ࣍ࣔ᥋ྜ࡛࠶ࡿⓎ➃⪅࡜࣊ࢸࣟ᥋ྜ࡛࠶ࡿ୧ぶࡣ
+LUVFKVSUXQJ ⑓ࢆᣢࡓ࡞࠿ࡗࡓࠋ('15% 㑇ఏᏊࡣ⫾⏕ᮇࡢ⚄⤒ሐࡢⓎ⏕ࠊ≉࡟⭠⟶ࡢ⚄⤒
࡜࣓ࣛࣀࢧ࢖ࢺࡢⓎ⏕࡟㠀ᖖ࡟㔜せ࡞ᙺ๭ࢆᢸࡗ࡚࠾ࡾࠊ:6 ࡜ +LUVFKVSUXQJ ⑓ࡢཎᅉ㑇ఏ
Ꮚࡢ ࡘ࡜ࡉࢀ࡚࠸ࡿࠋࡉࡽ࡟ᮏኚ␗ࡣ㔞౫Ꮡᛶ࡜࠸ࢃࢀ࡚࠾ࡾࠊ࣊ࢸࣟ᥋ྜ࠿࣍ࣔ᥋ྜ
࠿࡟ࡼࡗ࡚௜㝶ࡍࡿ :6 ࡢ⑕≧ࡸ +LUVFKVSUXQJ ⑓ࡢᾐ㏱⋡ࡶ␗࡞ࡾࠊྠࡌ ('15% ኚ␗ࢆ᭷
ࡍࡿᐙ⣔ෆ࡛ࡶྛ⑕≧ࡢ᭷↓ࡀ␗࡞ࡿࡇ࡜ࡶከ࠸࡜ሗ࿌ࡉࢀ࡚࠸ࡿࠋᮏ⑕౛࡟ࡣ :6 ࡢ⮫ᗋ
⑕≧ࡀ࠶ࡾࠊ୧ぶ࡟ࡣ࡞࠿ࡗࡓࡢࡣࠊ('15% ࡢኚ␗࢔ࣞࣝࡢ㔞౫Ꮡᛶ࡟ࡼࡿࡶࡢ࡛࠶ࡿࡇ࡜
ࡀ᥎ᐹࡉࢀࡓࠋ
:6 ࢆకࢃ࡞࠸ +LUVFKVSUXQJ ⑓ࡣ ('15% 㑇ఏᏊኚ␗ࡸ 5(7 㑇ఏᏊኚ␗࡞࡝」ᩘࡢ㑇ఏᏊᗙ
࡛ࡢ᫆⨯ᝈᛶ࢔ࣞࣝࡢ┦ຍⓗస⏝࡟ࡼࡾⓎ⑕ࡍࡿከᅉᏊ⑌ᝈ࡜ࡉࢀ࡚࠸ࡿࠋᮏ⑕౛ࡢ⮫ᗋ
⑕≧ࡢ୰࡟ +LUVFKVSUXQJ ⑓ࡀྵࡲࢀ࡞࠿ࡗࡓ⌮⏤ࡣࠊ+LUVFKVSUXQJ ⑓ࡢⓎ⑕࡟ᚲせ࡞௚ࡢ
㑇ఏᅉᏊࢆᣢࡓ࡞࠿ࡗࡓࡓࡵ࡜⪃࠼ࡽࢀࡓࠋ
ᮏ◊✲ࡣᡂ⫱་⒪◊✲ࢭࣥࢱ࣮⪥㰯ဗႃ⛉Ᏺᮏ೔Ꮚඛ⏕࡜ࡢඹྠ◊✲࡛࠶ࡿࠋ
― 46 ―
ࠝ⫈ぬ㞀ᐖ◊✲ᐊࠞ
Exome ゎᯒࢆ⏝࠸ࡓ⑕ೃ⩌ᛶ㞴⫈࡟ᑐࡍࡿཎᅉ㑇ఏᏊྠᐃࡢヨࡳ
ົྎⱥᶞ 1࣭௰㔝ᩔᏊ 2࣭᭷ᮏ཭ᏘᏊ 2࣭ᯇỌ㐩㞝 13
㸦1 ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ ឤぬჾࢭࣥࢱ࣮ ⫈ぬ㞀ᐖ◊✲ᐊ
㝔 ⪥㰯ဗႃ⛉
3 ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮
2
༓ⴥ┴ࡇ࡝ࡶ⑓
⮫ᗋ㑇ఏࢭࣥࢱ࣮㸧
せ ⣙
㑇ఏᛶ㞴⫈ࡀ␲ࢃࢀࡿᝈ⪅࡟࠾࠸࡚ࠊ㞴⫈㑇ఏᏊࡢಖ㝤᳨ᰝࡸ᪤▱ࡢ㞴⫈㑇ఏᏊࢆᑐ㇟
࡜ࡋࡓḟୡ௦ࢩ࣮ࢣࣥࢧ࣮࡟ࡼࡿゎᯒ࡛ࡣཎᅉࡀྠᐃ࡛ࡁ࡞࠸ࡇ࡜ࡶከ࠸ࠋࡇࡢ୰࡟ࡣᮍ
▱ࡢཎᅉ㑇ఏᏊࡢᏑᅾࡀ⌮⏤࡛࠶ࡿሙྜࡶྵࡲࢀࡿࠋ௒ᅇࠊ」ᩘࡢᑠወᙧࢆ࿊ࡍࡿ⑕ೃ⩌
ᛶ㞴⫈ᝈ⪅࡟ᑐࡍࡿ඲㑇ఏᏊࡢ࢚ࢡࢯࣥ㡿ᇦ㸦Exome㸧ࡢゎᯒࢆᐇ᪋ࡋࠊཎᅉೃ⿵ኚ␗ࡢ
ྠᐃࢆヨࡳࠊDLX5 ࡢ᪂⏕ኚ␗ࢆཎᅉೃ⿵࡜ࡋ࡚ྠᐃࡋࡓࠋ
┠ ⓗ
ඛኳᛶ㞴⫈ࡣ᪂⏕ඣ 1,000 ே࡟ 1 ேࡢ๭ྜ࡛Ⓨ⑕ࡋࠊࡑࡢ⣙༙ᩘࡣ㑇ఏᏊ⑌ᝈ࡜⪃࠼ࡽࢀ
࡚࠸ࡿࠋወᙧࢆక࠺㞴⫈ࡢཎᅉࡣࡲࡔᩘ✀㢮ࡋ࠿▱ࡽࢀ࡚࠾ࡽࡎࠊከࡃࡣཎᅉ୙࡛᫂࠶ࡿࠋ
ᙜ◊✲ᐊ࡛ࡣࡇࢀࡲ࡛᪤▱ࡢ⑕ೃ⩌ᛶ࣭㠀⑕ೃ⩌ᛶ㞴⫈㑇ఏᏊ 119 ✀ࢆᑐ㇟࡜ࡋࡓ⥙⨶ⓗ
㑇ఏᏊゎᯒࢆ⾜ࡗ࡚ࡁࡓࡀࠊࡇࢀ࡟ࡣෆ⪥ወᙧࡢཎᅉ㑇ఏᏊࡀྵࡲࢀ࡚࠸࡞࠸ྍ⬟ᛶࡀ࠶
ࡿࠋᮏ◊✲࡛ࡣࢱࣥࣃࢡ㉁ࢆࢥ࣮ࢻࡍࡿ඲㑇ఏᏊ(⣙ 20,000 ✀)ࡢࢥ࣮ࢻ㡿ᇦ㸦Exome㸧ࢆ
ᑐ㇟࡜ࡋࡓゎᯒࣃ࢖ࣉࣛ࢖ࣥࢆᵓ⠏ࡋࠊෆ⪥ወᙧ࡞࡝ࢆ࿊ࡍࡿ㞴⫈ཎᅉ㑇ఏᏊࢆ᥈⣴ࡍࡿ
ࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋᮏ◊✲ࡢᡂᯝࡣෆ⪥Ⓨ⏕࡞ࡽࡧ࡟ෆ⪥ወᙧⓎ⑕ࡢศᏊᶵᗎ࡟ᑐࡍࡿ⌮
ゎࢆ῝ࡵࠊࡼࡾṇ☜࡞㞴⫈㑇ఏᏊデ᩿ἲࡸ἞⒪ἲࡢ㛤Ⓨ࡬࡜ࡘ࡞ࡀࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ
᪉ἲ
ᑐ㇟ࡣ୧⼗∵๓ᗞపᙧᡂࠊཱྀ၁ཱྀ⵹⿣ࠊඛኳᛶ⮻⵹ᙧᡂ୙඲ࢆ࿊ࡋࡓዪඣ࡛࠶ࡿࠋᝈ⪅
ࡣ⏕ᚋᚎࠎ࡟㡢࡟ᑐࡍࡿ཯ᛂࡀపୗࡋࠊ1 ṓ 11 ࠿᭶ ࡢ ABR ࡛୧ഃ࡜ࡶ 105dB ࡢ㡢่⃭
࡛↓཯ᛂ࡛࠶ࡗࡓࠋᝈ⪅࡟ࡣ GJB2 ኚ␗࠾ࡼࡧ m.1555A>G, m.3243A>G ኚ␗ࡣ࡞࠿ࡗࡓࠋ
ࡲࡓྜేࡍࡿወᙧࡢ≉ᚩ࠿ࡽࠊ᪤▱ࡢ㠀⑕ೃ⩌ᛶ㞴⫈㑇ఏᏊࢆᑐ㇟࡜ࡋࡓゎᯒ࡟ࡼࡾཎᅉ
ኚ␗ࡀྠᐃࡉࢀࡿྍ⬟ᛶࡣప࠸࡜ண᝿ࡉࢀࡓࠋ
ᝈ⪅࠾ࡼࡧ೺⫈⪅୧ぶࡢ᳨య⾑ᾮ⏤᮶ DNA ࠿ࡽࠊAgilent ♫〇 SureSelect Exome V4
࠾ࡼࡧ Illumina ♫〇 Hiseq2000 ࢩ࣮ࢣࣥࢧ࣮ࢆ⏝࠸ DNA 㓄ิࢆᚓࡓࠋࣜࣇ࢓ࣞࣥࢫ㓄ิ
hg19/GRCh37 ୖ࡟࣐ࢵࣆࣥࢢᚋࠊ᳨ฟࡉࢀࡓኚ␗ࡢ࠺ࡕබඹࢹ࣮ࢱ࣮࣋ࢫ(1000Genome,
ESP6500, HGVD)ୖࡢ㢖ᗘࡀ㧗࠸ࡶࡢࢆ㝖ࡁࠊ࢔࣑ࣀ㓟㓄ิ࡟ᙳ㡪ࡢ࠶ࡿኚ␗࡟ࡘ࠸࡚ື
― 47 ―
≀✀㛫ಖᏑᛶࠊin house ࢹ࣮ࢱ࣮࣋ࢫ࡜ࡢẚ㍑࠾ࡼࡧᐙ⣔ෆゎᯒ࡟ࡼࡾཎᅉೃ⿵ࡢ⤠ࡾ㎸
ࡳࢆᐇ᪋ࡋࡓࠋ㑅ᢥࡉࢀࡓኚ␗ࡣ Sanger ἲ࡟ࡼࡾ☜ㄆࡋࡓࠋ
⤖ᯝ
Exome ゎᯒ࡟ࡼࡾ DLX5 ࡢ᪂つ࣑ࢫࢭࣥࢫኚ␗(c.569C>A; p.S190Y)ࡀ᪂⏕✺↛ኚ␗࡜ࡋ
࡚ྠᐃࡉࢀࡓࠋDLX5 ࡣᙧែᙧᡂ࡟㛵ࢃࡿ㌿෗ᅉᏊ࡛࠶ࡾࠊྠ࢔࣑ࣀ㓟ṧᇶࡣ࣓࣍࢜ࢻ࣓࢖
ࣥ࡟఩⨨ࡋ⬨᳝ື≀ 99 ✀඲࡚࡛ಖᏑࡉࢀ࡚࠸ࡓࠋࡲࡓࠊ❧యᵓ㐀ண ࠿ࡽࠊp.S190Y ኚ␗
ࡣ DLX5 ࢱࣥࣃࢡ㉁ࡢ DNA ⤖ྜ㒊఩࡟᪂ࡓ࡞Ỉ⣲⤖ྜࢆᙧᡂࡋࠊDNA ⤖ྜ⬟࡟ᙳ㡪ࢆ୚
࠼ࡿࡇ࡜ࡀண ࡉࢀࡓ㸦ᅗ㸯㸧ࠋ
ᅗ㸯
DLX5 ࡣ BMP ࡞࡝࡜ඹ࡟㦵ᙧᡂ࡟㔜せ࡞ᙺ๭ࢆᯝࡓࡍࡇ࡜ࡀ▱ࡽࢀࠊࡲࡓ Dlx5/Dlx6 ୧
Ḟኻ࣐࢘ࢫࡀෆ⪥࣭ୖ㢡࣭ୗ㢡పᙧᡂࢆ♧ࡍࡇ࡜࠿ࡽࠊ௒ᅇྠᐃࡉࢀࡓኚ␗ࡀᮏ⑕౛ࡢ⑕
≧ࡢཎᅉ࡛࠶ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡓ㸦2002 Science 298:381-385㸧ࠋᮏ㑇ఏᏊࡣ⿣ᡭ⿣㊊ࢆ
୺⑕≧࡜ࡋឤ㡢㞴⫈ࡶ࿊ࡍࡿ SHFM1D ࡢཎᅉ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠾ࡾ(2012 JMedGenet 49:
16-20. 2014 BirthDefResA 100:764. 2014 EurJHumGenet 22: 1105)ࠊ௒ᅇゎᯒᑐ㇟࡜ࡋࡓ
ᝈ⪅ࡢ⑕≧࡜୍⮴ࡋ࡞࠸Ⅼࡶ࠶ࡗࡓࠋ୍᪉ࠊDLX5 ࡢ enhancer 㒊఩ࢆ㏫఩࡟క࠸Ḟᦆࡋࡓ
ᐙ⣔ࡀ୍౛ሗ࿌ࡉࢀ࡚࠾ࡾ㸦2010 HumGenet 127: 19-31㸧ࠊ㞴⫈࠾ࡼࡧ㢌㒊㢦㠃␗ᖖࡢ⑕
≧ࡀ㢮ఝࡋ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡓ㸦ᅗ 2㸧ࠋ௒ᅇࡢ DLX5 ኚ␗ࢆ⑓ⓗኚ␗࡜ྠᐃࡍࡿࡓࡵ࡟ࡣࠊ
ྠᵝࡢ⑕≧ࢆࡶࡘ」ᩘࡢ⑕౛ࡢゎᯒࡀᚲせ࡜⪃࠼ࡽࢀࡓࠋ
― 48 ―
ᅗ㸰
― 49 ―
ࠝ⫈ぬ㞀ᐖ◊✲ᐊࠞ
㞴⫈㑇ఏᏊ LOXHD1 ࡢ᪂つኚ␗యࡢศᏊ⑓ែࡢ᳨ド
㞴Ἴ୍ᚨ
㸦⫈ぬ㞀ᐖ◊✲ᐊ㸧
せ ⣙
LOXHD1 ࡣෆ⪥ࡢ᭷ẟ⣽⬊ࡢ୙ືẟࡢ⣽⬊⭷࡟ᒁᅾࡋࠊࡑࡢ㑇ఏᏊࡢ⑓ⓗኚ␗ࡣ㐍⾜ᛶ
㞴⫈ࡢཎᅉ࡜࡞ࡿࠋᡃࠎࡣ 2014 ᖺ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࡟࠾࠸࡚ࠊ⣧㡢⫈ຊ᳨ᰝ࡛୧ഃ
ᛶ࡟㧗㡢₞ഴᆺࡢឤ㡢㞴⫈ࢆ࿊ࡋࡓᝈ⪅࡟࠾࠸࡚ LOXHD1 ࡢ᪂つ㑇ఏᏊኚ␗(p.V1892F)
ࢆሗ࿌ࡋࡓࠋLOXHD1 ࡣࠊ୙㣬࿴⬡⫫㓟㓟໬㓝⣲ lipoxygenase ࡀ᭷ࡍࡿ PLAT ࢻ࣓࢖ࣥ
ࡢࡳࡀከᩘ┤ิࡋࡓᵓ㐀ࢆࡶࡕࠊᮏኚ␗ࡶࡇࡢ PLAT ࢻ࣓࢖ࣥ࡟ㄆࡵࡽࢀࡓࠋLOXHD1 ࡢ
⫈ぬ࡟࠾ࡅࡿᶵ⬟ࡣࡲࡔ୙࡛᫂࠶ࡿࡀࠊPLAT ࢻ࣓࢖ࣥࡣ Ca
2+
౫Ꮡⓗ࡞⬡㉁⭷࡬ࡢ⤖ྜ
࡟ാࡃ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ
ᮏ◊✲࡛ࡣᮏኚ␗ࡢ㞴⫈ࡢཎᅉ࡜ࡋ࡚ࡢ᳨ドࢆ┠ⓗ࡜ࡋ࡚ࠊLOXHD1 ࡢ PLAT ࢻ࣓࢖ࣥ
ࡢ⺮ⓑ㉁❧యᵓ㐀ࢆண ࡋࡓ࡜ࡇࢁࠊPLAT ࢻ࣓࢖ࣥࡢෆഃ࡟఩⨨ࡋ࡚࠸ࡓ 1892 ␒┠ࡢࣂ
ࣜࣥ(V)ࡀࣇ࢙ࢽࣝ࢔ࣛࢽࣥ(F)࡟⨨᥮ࡉࢀࡿࡇ࡜࡟ࡼࡾࠊ࢔࣑ࣀ㓟ഃ㙐ࡢཎᏊྠኈࡢ≀⌮ⓗ
┦஫స⏝࡟ࡼࡿ⾪✺ࡀ⏕ࡌࡿࡇ࡜ࡀゎࡗࡓࠋࡇࢀ࡟ࡼࡾ LOXHD1 ࡢ PLAT ࢻ࣓࢖ࣥࡢșࣂ
ࣞࣝᵓ㐀㸦ᶡ≧ࡢᵓ㐀㸧ࡀኚᙧࡋ࡚⬡㉁⭷࡜ࡢ⤖ྜ⬟ࡀపୗࡋࠊ᭷ẟ⣽⬊୙ືẟࡢᶵ⬟ࡀ
㞀ᐖࡉࢀ࡚㞴⫈ࢆⓎ⑕ࡋࡓ࡜ண ࡉࢀࡓࠋ
┠ ⓗ
p.V1892F ኚ␗࡟ࡼࡾ LOXHD1 ࡢ PLAT ࢻ࣓࢖ࣥࡢ❧యᵓ㐀ࡀ࡝ࡢࡼ࠺࡟㞀ᐖࡉࢀࡿࡇ࡜
࡟ࡼࡾ㞴⫈ࡢཎᅉ࡜࡞ࡾ࠺ࡿ࠿᳨ドࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࠊLOXHD1 ࡢ PLAT ࢻ࣓࢖ࣥࡢ⺮
ⓑ㉁❧యᵓ㐀ࢆண ࡋࠊᮏኚ␗࡟ࡼࡿᙳ㡪ࢆゎᯒࡋࡓࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
LOXHD1 ࡢ ⤖ ᬗ ᵓ 㐀 ࡀ ᮍ ▱ ࡢ ࡓ ࡵ ࠊ ࢔ ࣑ ࣀ 㓟 㓄 ิ ࡢ 㧗 ࠸ ಖ Ꮡ ᛶ ࢆ ♧ ࡋ ࡓ ࢧ ࣥ ࢦ
lipoxygenase ࡢ PLAT ࢻ࣓࢖ࣥࡢ⤖ᬗᵓ㐀(PDB:2fnq)ࢆ㗪ᆺ࡟ࠊṇᖖᆺ࡜ኚ␗ᆺࣄࢺ
LOXHD1 ࡢ PLAT ࢻ࣓࢖ࣥࡢ❧యᵓ㐀ண ࢆ⾜ࡗࡓࠋᮏᵓ㐀ண ࡟౑⏝ࡋࡓࣉࣟࢢ࣒ࣛࡣࠊ
Swiss Model㸦ศᏊࣔࢹࣜࣥࢢ㸧ࠊ࠾ࡼࡧ UCSF Chimera㸦ศᏊ⾲♧㸧ࢆ⏝࠸ࡓࠋ
― 50 ―
⤖ ᯝ
V1892 ࡣࠊșࣂࣞࣝࢆᵓᡂࡍࡿ 7 ࡘࡢșࢩ࣮ࢺ㸦ᖹ㠃≧ࡢᵓ㐀࡛ᮏᶡ≧ᵓ㐀ࡢഃቨ㠃ࢆ
ᵓᡂ㸧ࡢ࠺ࡕ N ᮎ➃࠿ࡽ 4 ␒┠ࡢșࢩ࣮ࢺ࡟࠶ࡾࠊࡑࡢ࢔࣑ࣀ㓟ഃ㙐ࡣșࣂࣞࣝࡢෆ㒊࡟
఩⨨ࡋࡓ(ࢫࢸࣞ࢜ᅗ 1, ▮༳)ࠋ
㟁Ⲵࢆᣢࡓ࡞࠸࢔࣑ࣀ㓟ྠኈ࡛ࡣࠊ࢔࣑ࣀ㓟ࢆᵓᡂࡍࡿྛཎᏊࡢ༙ᚄ㊥㞳㸦ࣇ࢓ࣥࢹࣝ
࣮࣡ࣝࢫ༙ᚄ㸧ࢆ࡜ࡿ᪉ྥ࡟≀⌮ⓗ࡞┦஫స⏝ࡀാࡃࠋࡇࡢኚ␗㒊఩ࡢ࢔࣑ࣀ㓟ࡢࣇ࢓ࣥ
ࢹ࣮ࣝ࣡ࣝࢫ༙ᚄࢆ᳨ウࡋࡓ࡜ࡇࢁࠊṇᖖᆺࡢ V1892 ࡣ࢔࣑ࣀ㓟ഃ㙐ࡀșࣂࣞࣝෆࡢ௚ࡢ
࢔࣑ࣀ㓟ഃ㙐࡜⾪✺ࡋ࡞࠸ࡀࠊ⨨᥮ࡉࢀࡓ F1892 ࡛ࡣ⾪✺ࡍࡿࡇ࡜ࡀゎࡗࡓࠋ୍᪉ࠊV1892
ࡣ Ca2+ ⤖ྜ㒊఩࠿ࡽ㞳ࢀࡓ㊥㞳࡟࠶ࡗࡓࡓࡵࠊᮏኚ␗ࡣ Ca2+ ࡢ⤖ྜ࡟ࡣᙳ㡪ࡋ࡞࠸ࡇ࡜
ࡀゎࡗࡓ(ࢫࢸࣞ࢜ᅗ 1, ྑ 3 ࡘࡢ⌫㸧
ࠋ
ࢫࢸࣞ࢜ᅗ㸯
ศᏊࣔࢹࣜࣥࢢ࡟ࡼࡿ LOXHD1 ࡢᵓ㐀ࠋᖹ㠃≧ࢺ࣏ࣟࢪ࣮㸸
șࢩ࣮ࢺࠋࣛ࢖ࣥ≧ࢺ࣏ࣟࢪ࣮㸸࣮ࣝࣉࠋ⌫≧ᵓ㐀㸸Ca2+
― 51 ―
ࠝ⫈ぬ㞀ᐖ◊✲ᐊࠞ
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤Ⓨ࡟㛵ࡍ
ࡿ◊✲
༡ಟྖ㑻
㸦⮫ᗋ◊✲ࢭࣥࢱ࣮ ⫈ぬᖹ⾮ぬ◊✲㒊㸧
せ ⣙
୰⪥ᖖᅾ⳦ྀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊ୰⪥࡟⅖⑕ࡢ↓࠸⪥⛉ᡭ⾡㸦⫏࡟ᑐࡍࡿேᕤෆ⪥ࠊ⪥
◳໬⑕࡟ᑐࡍࡿ࢔ࣈ࣑㦵ᡭ⾡ࠊ࣋ࣝ㯞⑷࡟ᑐࡍࡿ㢦㠃⚄⤒ῶⲴ⾡ࠊ୰⪥ወᙧ࡟ᑐࡍࡿ㰘ᐊ
ᙧᡂ⾡㸧ࢆ⾜ࡗࡓ 66 ⑕౛࠿ࡽ୰⪥ࢫ࣡ࣈࢧࣥࣉࣝࢆ᥇ྲྀࡋࠊ16S rRNA ࣓ࢱࢤࣀ࣒ゎᯒࢆ
᏶஢ࡋࡓࠋ࠸ࡎࢀࡢࢧࣥࣉࣝ࠿ࡽࡶ⣽⳦ࡢᏑᅾࢆ♧ࡍ 16S rRNA 㡿ᇦࡀ PCR ࡼࡾᚓࡽࢀࡓࠋ
ᡂே୰⪥ᖖᅾ⳦ྀࡣࠊ㛛࡛ࣞ࣋ࣝ Proteobacteria 55%ࠊActinobacteria 29%ࠊFirmicutes
12%ࠊBacteroidetes 2%࡜࠸࠺⤖ᯝ࡛࠶ࡗࡓࠋ៏ᛶ୰⪥⅖ࡢ⣽⳦ྀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊ៏
ᛶ୰⪥⅖ᝈ⪅ 88 ౛ࡼࡾᡭ⾡᫬࡟୰⪥ࢫ࣡ࣈࢧࣥࣉࣝࢆ᥇ྲྀࡋࠊ16S rRNA ࣓ࢱࢤࣀ࣒ゎᯒ
ࢆ᏶஢ࡋࡓࠋ⪥₃ࡢ࡞࠸஝⇱ࡋࡓ㠀άືᛶ៏ᛶ୰⪥⅖⪥㸦㠀άືᛶ COM㸧࡛ࡣࠊࢥࣥࢺࣟ
࣮ࣝ⩌࡟㢮ఝࡋࡓ⣽⳦ྀ࡛࠶ࡗࡓࡀࠊ⪥₃ࡢ࠶ࡿάືᛶ៏ᛶ୰⪥⅖⪥㸦άືᛶ COM㸧࡛ࡣࠊ
Proteobacteria ࡢ๭ྜࡀపୗࡋࠊFirmicutes ࡢ๭ྜࡀቑຍࡋ࡚࠸ࡓࠋ⌧ᅾࡲ࡛࡟୰⪥ᖖᅾ
⳦ྀࢆୡ⏺࡛ึࡵ࡚᫂ࡽ࠿࡟ࡋࠊ㞴ᇵ㣴ᚤ⏕≀ࡢ៏ᛶ୰⪥⅖࡬ࡢ㛵୚ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ㠀
άືᛶ COM ࡛ࡣᖖᅾ⳦ྀ࡟㢮ఝࡋࡓ⣽⳦ྀ࡛࠶ࡗࡓࡀࠊάືᛶ COM ࡛ࡣ⣽⳦ྀࡣᖖᅾ⳦
ྀ࡜ࡣ᫂ࡽ࠿࡟ኚ໬ࡋ࡚࠸ࡿࡇ࡜ࡀุ᫂ࡋࡓࠋ
┠ ⓗ㸦ࡲࡓࡣ◊✲┠ⓗ㸧
ே㛫ࡢయ࡟ࡣࠊከ✀ከᵝ࡞⣽⳦ྀࡀᏑᅾࡍࡿࡀࠊࡑࡢከࡃࡀᚑ᮶ࡢᇵ㣴ἲ࡟ࡼࡿ⣽⳦᳨
ᰝ࡛ࡣྠᐃᅔ㞴࡞㞴ᇵ㣴ᚤ⏕≀࡜ࡉࢀࡿࠋḟୡ௦ࢩ࣮ࢡ࢚ࣥࢧ࣮ࢆ⏝࠸ࡓ 16S rRNA ࣓ࢱ
ࢤࣀ࣒ゎᯒ࡛ࡣࠊ㞴ᇵ㣴ᚤ⏕≀ࡶྵࡵࡓ඲࡚ࡢ⣽⳦ྀ࡟ྵࡲࢀࡿ DNA ࢆ୸ࡈ࡜ゎᯒࡋࠊ⣽
⳦ࢆ᳨ฟ࣭ྠᐃࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࠋᮏ◊✲ࡢ┠ⓗձࡣୡ⏺࡛ึࡵ࡚ேࡢ୰⪥ᖖᅾ⳦ྀ
ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡛࠶ࡿࠋ┠ⓗղࡣ៏ᛶ୰⪥⅖ࡢᝈ⪅ࢆᑐ㇟࡟୰⪥⣽⳦ྀࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜࡛࠶ࡿࠋᚑ᮶ࡢᇵ㣴ἲ࡛ࡣྠᐃࡉࢀ࡞࠸㞴ᇵ㣴ᚤ⏕≀ࡀ⑓ⓗ⣽⳦࡜ࡋ࡚㛵ࢃࡗ࡚࠸
ࡿࡇ࡜ࡀண᝿ࡉࢀࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ㸦ࡲࡓࡣ᪉ἲ㸧
◊✲ࢹࢨ࢖ࣥࡣࠊ୰⪥࡟⅖⑕ࡢ࡞࠸⪥⛉ᡭ⾡⑕౛࡜ࠊ៏ᛶ୰⪥⅖ࡢ㰘ᐊᙧᡂ⾡⑕౛࠿ࡽࠊ
୰⪥⢓⭷ࢫ࣡ࣈࢆヨᩱ࡜ࡋࠊ16S rRNA ࣓ࢱࢤࣀ࣒ゎᯒࢆ⾜࠺ほᐹ◊✲࡛࠶ࡿࠋ16S rRNA
࣓ࢱࢤࣀ࣒ゎᯒࡣࢧࣥࣉࣝࡼࡾ DNA ᢳฟᚋ 16S 㑇ఏᏊࡢྍኚ㡿ᇦ V4 ࢆྵࡴ㡿ᇦࡢ PCR
― 52 ―
ቑᖜ࠾ࡼࡧࢩ࣮ࢡ࢚ࣥࢫࢆ⾜࠸ࠊࡑࢀࡒࢀࡢ㓄ิ㛫ࡢ㢮ఝᗘ࠿ࡽ⳦✀ࡢ≉ᐃࡸ⳦ྀ඲యࡢ
ᵓ㐀ࢆゎᯒࡋࡓࠋ┠ⓗձࡢ୰⪥ᖖᅾ⳦ྀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊ୰⪥࡟⅖⑕ࡢ↓࠸⪥⛉ᡭ⾡
㸦⫏࡟ᑐࡍࡿேᕤෆ⪥ࠊ⪥◳໬⑕࡟ᑐࡍࡿ࢔ࣈ࣑㦵ᡭ⾡ࠊ࣋ࣝ㯞⑷࡟ᑐࡍࡿ㢦㠃⚄⤒ῶⲴ
⾡ࠊ୰⪥ወᙧ࡟ᑐࡍࡿ㰘ᐊᙧᡂ⾡㸧ࢆ⾜ࡗࡓ 66 ⑕౛࠿ࡽ୰⪥ࢫ࣡ࣈࢧࣥࣉࣝࢆ᥇ྲྀࡋࠊ16S
rRNA ࣓ࢱࢤࣀ࣒ゎᯒࢆ᏶஢ࡋࡓࠋ┠ⓗղࡢ៏ᛶ୰⪥⅖ࡢ⣽⳦ྀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊ៏ᛶ
୰⪥⅖ᝈ⪅ 88 ౛ࡼࡾᡭ⾡᫬࡟୰⪥ࢫ࣡ࣈࢧࣥࣉࣝࢆ᥇ྲྀࡋࠊ16S rRNA ࣓ࢱࢤࣀ࣒ゎᯒࢆ
᏶஢ࡋࡓࠋ
⤖ ᯝ㸦ࡲࡓࡣᡂ⦼㸧
࠸ࡎࢀࡢࢧࣥࣉࣝ࠿ࡽࡶ⣽⳦ࡢᏑᅾࢆ♧ࡍ 16S rRNA 㡿ᇦࡀ PCR ࡼࡾᚓࡽࢀࡓࠋᑠඣࡢ
୰⪥ᖖᅾ⳦ྀࡣࠊ㛛࡛ࣞ࣋ࣝ Proteobacteria 62%ࠊActinobacteria 33%ࠊBacteroidetes 2%ࠊ
Firmicutes 2%࡜࠸࠺⤖ᯝ࡛࠶ࡗࡓࠋᡂேࡢ୰⪥ᖖᅾ⳦ྀࡣࠊ㛛࡛ࣞ࣋ࣝ Proteobacteria
55%ࠊActinobacteria 29%ࠊFirmicutes 12%ࠊBacteroidetes 2%࡜࠸࠺⤖ᯝ࡛࠶ࡗࡓࠋᒓ
࡛ࣞ࣋ࣝࡣ 62 ⳦✀ࡀ୰⪥ᖖᅾ⳦࡜ࡋ࡚᫂ࡽ࠿࡟࡞ࡗࡓࠋ⪥₃ࡢ࡞࠸஝⇱ࡋࡓ㠀άືᛶ៏ᛶ
୰⪥⅖⪥㸦㠀άືᛶ COM㸧࡛ࡣࠊ┿⌔⭘ࡢ࡞࠸༢⣧៏ᛶ୰⪥⅖࡛ Proteobacteria (46%)ࠊ
Actinobacteria (28%)ࠊFirmicutes (22%)ࠊBacteroidetes (3%)࡛࠶ࡾࠊ┿⌔⭘ࢆక࠺┿⌔
⭘ ᛶ ୰ ⪥ ⅖ ࡛ Proteobacteria (62%) ࠊ Actinobacteria (25%), Firmicutes (10%) ࠊ
Bacteroidetes (3%)࡛࠶ࡗࡓࠋ୍᪉ࠊ⪥₃ࡢ࠶ࡿάືᛶ៏ᛶ୰⪥⅖⪥㸦άືᛶ COM㸧࡛ࡣࠊ
┿⌔⭘ࡢ࡞࠸༢⣧៏ᛶ୰⪥⅖࡛ Proteobacteria (40%)ࠊFirmicutes (29%)ࠊActinobacteria
(26%)ࠊBacteroidetes (3%)࡛࠶ࡾࠊ┿⌔⭘ࢆక࠺┿⌔⭘ᛶ୰⪥⅖࡛ Firmicutes(41%)ࠊ
Actinobacteria (30%)ࠊProteobacteria (23%)ࠊBacteroidetes (4%)࡜ Firmicutes ࡢ๭ྜࡀ
ቑຍࡋࠊProteobacteria ࡢ๭ྜࡀపୗࡋ࡚࠸ࡓࠋ
ࡲ࡜ࡵࡿ࡜ࠊ⌧ᅾࡲ࡛࡟୰⪥ᖖᅾ⳦ྀࢆୡ⏺࡛ึࡵ࡚᫂ࡽ࠿࡟ࡋࠊ㞴ᇵ㣴ᚤ⏕≀ࡢ៏ᛶ
୰⪥⅖࡬ࡢ㛵୚ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ㠀άືᛶ COM ࡛ࡣᖖᅾ⳦ྀ࡟㢮ఝࡋࡓ⣽⳦ྀ࡛࠶ࡗࡓࡀࠊ
άືᛶ COM ࡛ࡣ⣽⳦ྀࡣᖖᅾ⳦ྀ࡜ࡣ᫂ࡽ࠿࡟ኚ໬ࡋ࡚࠸ࡿࡇ࡜ࡀุ᫂ࡋࡓࠋ
― 53 ―
ᅗ㸯㸸16S rRNA ࣓ࢱࢤࣀ࣒ゎᯒ⤖ᯝ
― 54 ―
ࠝ⫈ぬ㞀ᐖ◊✲ᐊࠞ
ෆ⪥እഃቨ⥺⥔⣽⬊ࡢ෌⏕࡜⼗∵ෆ㟁఩
Ỉ㊊㑥㞝
㸦⫈ぬᖹ⾮ぬ◊✲㒊㸧
せ ⣙
࣐࢘ࢫ࡟࠾࠸࡚QLWURSURSLRQLFDFLG13࡟ࡼࡿᛴᛶෆ⪥࢚ࢿࣝࢠ࣮୙඲ࣔࢹࣝࢆస
ᡂࡋࡓࠋࡑࡢ⤖ᯝ࣐࢘ࢫ࡟࠾࠸࡚13ᢞ୚ᚋࡢ⫈ᛶ⬻ᖿㄏⓎ཯ᛂ$%5㜈್ୖ᪼ࡀㄆࡵࡽࢀ
ࡓࠋࡉࡽ࡟⤌⧊Ꮫⓗ࡞᳨ウࢆ⾜ࡗࡓ࡜ࡇࢁࠊࡑࡢཎᅉࡀ⼗∵እഃቨ⥺⥔⣽⬊࡟≉␗ⓗ࡟⏕
ࡌࡿ࢔࣏ࢺ࣮ࢩࢫ࡟ࡼࡿࡶࡢ࡛࠶ࡿࡇ࡜ࢆගᏛ㢧ᚤ㙾ୗ࡟☜ㄆࡋࡓࠋࡇࡢ13ࣔࢹ࣐ࣝ࢘
ࢫࢆ13ᢞ୚ᚋࣨ᭶ࡲ࡛⤒㐣ほᐹࡍࡿ࡜ࠊప㡢ᇦ࠿ࡽ୰㡢ᇦࡲ࡛ࡢ$%5㜈್࡟᭷ព࡞ᨵၿ
ࡀㄆࡵࡽࢀࡓࠋࡉࡽ࡟ࠊ⼗∵ෆ㟁఩HQGRFRFKOHDUSRWHQWLDOࢆ ᐃࡋࡓ࡜ࡇࢁࠊ13ᢞ
୚࡟ࡼࡗ࡚పୗࡋࡓ㟁఩ࡀᨵၿࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࡢ㟁఩ࡢᅇ᚟ࡣ⼗∵እ
ഃቨ࡟࠾ࡅࡿFRQQH[LQ࠾ࡼࡧ1DN$73DVHࡢ෌Ⓨ⌧࡟ࡼࡗ࡚⏕ࡌࡿࡇ࡜ࢆ☜ㄆࡋࡓࠋ௨ୖ
࡟ࡼࡾࠊ⮬Ⓨⓗ࡞⼗∵እഃቨ⥺⥔⣽⬊ࡢ෌⏕࡟ࡼࡿ⼗∵ෆ㟁఩ࡢᅇ᚟࡟ࡼࡾ⫈ຊࡢᨵၿࢆ
᮶ࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
┠ ⓗ㸦ࡲࡓࡣ◊✲┠ⓗ㸧
࣑ࢺࢥࣥࢻࣜ࢔ࡢ㟁Ꮚఏ㐩⣔ࡢ୙ྍ㏫ⓗ㜼ᐖ๣࡛࠶ࡿ QLWRURSURSLRQLF DFLG13ࢆෆ⪥
࡟ᒁᡤᢞ୚ࡋసᡂࡋࡓᛴᛶෆ⪥࢚ࢿࣝࢠ࣮୙඲ࣔࢹࣝࢆ⏝࠸࡚ࠊ⼗∵እഃቨ⥺⥔⣽⬊ࡢ⮬
Ⓨⓗእഃቨ෌⏕ࡢ࣓࢝ࢽࢬ࣒ࢆゎᯒࡋࠊࡉࡽ࡟እഃቨ⥺⥔⣽⬊෌⏕ࡀ⼗∵ෆ㟁఩࡟୚࠼ࡿ
ᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ㸦ࡲࡓࡣ᪉ἲ㸧
QLWURSURSLRQLFDFLG13࡟ࡼࡿᛴᛶෆ⪥࢚ࢿࣝࢠ࣮୙඲ࣔࢹࣝࢆ &%$&D- ࣐࢘ࢫࢆ⏝࠸
࡚సᡂࡍࡿࠋࡑࡢᚋ⤒᫬ⓗ࡟⫈ᛶ⬻ᖿㄏⓎ཯ᛂ$%5ࢆ඲㌟㯞㓉ୗ࡟⾜࠸ࠊ$%5 㜈್ኚ໬
ࢆ⏕ࡌࡿ࠿☜ㄆࡍࡿࠋ࣐࢘ࢫ࡟࠾࠸࡚ 13 ᢞ୚ᚋ $%5 㜈್ୖ᪼ࡀㄆࡵࡽࢀࢀࡤࠊࡲࡎග
Ꮫ㢧ᚤ㙾ୗ࡟እഃቨ⥺⥔⣽⬊ࠊ⾑⟶᮲ࠊ࠾ࡼࡧࢥࣝࢳჾ࡜ࡽࡏࢇ⚄⤒⠇ࡢほᐹࢆ⾜࠺ࠋ⥆
࠸࡚ࠊ⤒᫬ⓗ࡞⼗∵ෆ㟁఩㸦HQGRFRFKOHDUSRWHQWLDO(3㸧ࡢ ᐃࢆ⾜࠺ࠋࡉࡽ࡟ࠊ⤒᫬ⓗ࡞⼗
∵እഃቨ࡟࠾ࡅࡿ FRQQH[LQ ࠾ࡼࡧ 1DN$73DVH ࡢⓎ⌧ࢆච␿ᰁⰍ࡟ࡼࡾ☜ㄆࡍࡿࠋ
ͤ1 ⾜࠶ࡅࡿ
⤖ ᯝ㸦ࡲࡓࡣᡂ⦼㸧
QLWURSURSLRQLFDFLG13࡟ࡼࡿᛴᛶෆ⪥࢚ࢿࣝࢠ࣮୙඲ࣔࢹࣝࢆ &%$&D- ࣐࢘ࢫࢆ
― 55 ―
⏝࠸࡚సᡂࡋࡓࠋࡑࡢ⤖ᯝ࣐࢘ࢫ࡟࠾࠸࡚ࣛࢵࢺ࡟࠾࠸࡚ほᐹࡉࢀࡓ 13 ᢞ୚ᚋࡢ $%5 㜈
್ୖ᪼ࡀྠᵝ࡟ㄆࡵࡽࢀࡓࠋࡉࡽ࡟⤌⧊Ꮫⓗ࡞᳨ウࢆ⾜ࡗࡓ࡜ࡇࢁࠊෆ⪥ᒁᡤⓗ࡞࣑ࢺࢥ
ࣥࢻࣜ࢔ᶵ⬟㜼ᐖ࡟ࡼࡾ㧗ᗘࡢ⫈ᛶ⬻ᖿㄏⓎ཯ᛂ$%5㜈್ୖ᪼ࡀㄆࡵࡽࢀ+R\DHWDO
1HXURUHSRUWࠊࡑࡢཎᅉࡀ⼗∵እഃቨ⥺⥔⣽⬊࡟≉␗ⓗ࡟⏕ࡌࡿ࢔࣏ࢺ࣮ࢩࢫ࡟ࡼ
ࡿࡶࡢ࡛࠶ࡿࡇ࡜ࢆගᏛ㢧ᚤ㙾ୗ࡟☜ㄆࡋࡓࠋࡇࡢ 13 ࣔࢹ࣐ࣝ࢘ࢫࢆ 13 ᢞ୚ᚋ ࣨ
᭶ࡲ࡛⤒㐣ほᐹࡍࡿ࡜ࠊప㡢ᇦ࠿ࡽ୰㡢ᇦࡲ࡛ࡢ $%5 㜈್࡟᭷ព࡞ᨵၿࡀㄆࡵࡽࢀࡓࠋ⤌
⧊Ꮫⓗ࡟ࡣእഃቨ⥺⥔⣽⬊ࠊ≉࡟ , ᆺࠊ,9 ᆺ࡟࠾࠸࡚⣽⬊ศ⿣ࢆక࠺⮬Ⓨⓗ࡞෌⏕ࡀㄆࡵ
ࡽࢀࡓࠋࡉࡽ࡟ࠊ⼗∵ෆ㟁఩HQGRFRFKOHDUSRWHQWLDOࢆ ᐃࡋࡓ࡜ࡇࢁࠊ13 ᢞ୚࡟ࡼ
ࡗ࡚పୗࡋࡓ㟁఩ࡀᨵၿࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡉࡽ࡟ච␿⤌⧊Ꮫⓗ᳨ウ࡟ࡼࡾࠊ
⼗∵እഃቨ࡟࠾ࡅࡿ FRQQH[LQ ࠾ࡼࡧ 1DN$73DVH ࡢ෌Ⓨ⌧ࡀぢࡽࢀࡓࠋ௨ୖ࡟ࡼࡾࠊ⮬
Ⓨⓗ࡞⼗∵እഃቨ⥺⥔⣽⬊ࡢ෌⏕ࡣ⼗∵ෆ㟁఩ࡢᅇ᚟࡟ࡼࡾ⫈ຊࡢᨵၿࢆ᮶ࡋ࡚࠸ࡿࡇ࡜
ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
― 56 ―
ࠝᖹ⾮ぬ㞀ᐖ◊✲ᐊࠞ
㞴἞ᛶᮎᲈᛶࡵࡲ࠸ࡢ㔜⑕ᗘ࡟ᙳ㡪ࡍࡿᚰ⌮♫఍ⓗせᅉࡢ᳨ウ
஬ᓥྐ⾜ࠊⲨ஭⨾ᕼࠊ∦ᒸᯞ㔛Ꮚࠊఀ㐩ዉ⨾ࠊ୕ᾆṇ⛱
㸦ᖹ⾮ぬ㞀ᐖ◊✲ᐊ㸧
せ ⣙
୍⯡ⓗ἞⒪࡟ࡶ࠿࠿ࢃࡽࡎࡵࡲ࠸࡟ࡼࡿ⏕ά㞀ᐖࢆッ࠼ࡿ㞴἞ᛶᮎᲈᛶࡵࡲ࠸ᝈ⪅ࢆᑐ
㇟࡜ࡋ࡚㔜⑕ᗘ࡟ᙳ㡪ࡍࡿᚰ⌮♫఍ⓗせᅉࢆ᳨ウࡋࡓࠋ㞴἞ᛶࡵࡲ࠸࡟࠾࠸࡚㌟యឤぬ࡟
ᑐࡍࡿ◚ᒁⓗᛮ⪃ࡣ㔜⑕ᗘ࡟ᙳ㡪ࢆ୚࠼࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾㄆ▱ࡢṍࡳࡀᙳ㡪ࢆཷ
ࡅࡿ⑓ែ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡑࡢ௚ࡢ⫼ᬒᅉᏊࡢ୰࡛ࡣࡵࡲ࠸㔜ᗘ⩌࡛ࡣᑵປࡋ࡚
࠸ࡿࡶࡢࡀከࡃ௒ᚋࡢ᳨ウ஦㡯࡟እⓗ࡞せᅉ࡜ࡋ࡚⫋ሙ࡛ࡢே㛫㛵ಀࡸࢧ࣏࣮ࢺ࡞࡝ࡢ♫
఍ⓗ⎔ቃᅉᏊࡀ⪃࠼ࡽࢀࡓࠋ
┠ ⓗ
ࡵࡲ࠸ࡣᵝࠎ࡞せᅉ࡛⏕ࡌࡿࠋཎᅉࡣ࣓ࢽ࢚࣮ࣝ⑓ࡸ๓ᗞ⚄⤒⅖࡞࡝ࡢ๓ᗞ⑌ᝈ࡟ࡼࡿᮎ
ᲈ๓ᗞᛶࡵࡲ࠸⬻⾑⟶㞀ᐖ࡞࡝ࡢ୰ᯡ⚄⤒⑌ᝈ࡟ࡼࡿ୰ᯡᛶࡵࡲ࠸⢭⚄་Ꮫⓗ࣭ᚰ⌮ⓗせ
ᅉ࡟ࡼࡿࡵࡲ࠸࡟ศࡅࡿࡇ࡜ࡀฟ᮶ࡿࠋࣉࣛ࢖࣐ࣜࢣ࢔እ᮶ᩆᛴእ᮶ࡵࡲ࠸ᑓ㛛እ᮶࡟࠾
ࡅࡿࡵࡲ࠸ࡢཎᅉࡢ๭ྜࡣ࠾࠾ࡴࡡ୍⮴ࡋᮎᲈ๓ᗞᛶࡀ 㸣୰ᯡᛶࡀ 㸣⢭⚄㞀
ᐖࡀ 㸣௚ࡢཎᅉࡀ 㸣ཎᅉ୙᫂ࡀ 㸣࡛࠶ࡗࡓ ࠋⓎ⑕ࡢཎᅉ࡜ࡋ࡚ᚰ⌮
♫఍ⓗࢫࢺࣞࢫࡣ㔜せ࡞ࡶࡢ࡛࠶ࡿࠋ἞⒪ࡣ୍⯡ⓗ࡟ࡣ⸆≀἞⒪ࡀ⾜ࢃࢀࡿࡀ୍㒊ࡢ⑕౛
࡛ࡣ⑕≧ࡢᨵၿࡀᚓࡽࢀࡎ㞴἞໬ࡍࡿࠋࡵࡲ࠸⑕≧ࡢ㞴἞໬࡟ࡣᝈ⪅ࡢㄆ▱ࡢၥ㢟ࡀᙳ㡪
ࡋ࡚࠸ࡿྍ⬟ᛶࡀ࠶ࡿࠋ௒ᅇ≉࡟㌟య⾲⌧ᛶ㞀ᐖ࡛ὀ┠ࡉࢀ࡚࠸ࡿ㌟యឤぬቑᖜ࡜㌟యឤ
ぬ࡟ᑐࡍࡿ◚ᒁⓗᛮ⪃࡟ὀ┠ࡋࡓࠋ
㌟యឤぬቑᖜ࡜ࡣ㌟యឤぬࢆᙉࡃ᭷ᐖ࡟ᨭ㞀࠶ࡿࡶࡢ࡜ࡋ࡚ឤࡌࡿഴྥࡢࡇ࡜ࢆ࠸࠺ ࠋ
ࡇࡢഴྥࡣ⏕ୗ᫬࠿ࡽഛࢃࡗࡓᏳᐃⓗ࡞▱ぬ≉ᛶ࡛࠶ࡿ࡜ྠ᫬࡟≉ᐃࡢឤぬ࡟ࡘ࠸࡚␗
࡞ࡗࡓ≧ἣ࡛ࡣ␗࡞ࡗࡓ⛬ᗘ࡛ឤ▱ࡋ࠺ࡿ࡜࠸࠺≧ែ≉ᛶࡢ୧᪉ࡢᛶ㉁ࢆྵࢇ࡛࠸ࡿࠋ㌟
యឤぬ࡟ᑐࡍࡿ◚ᒁⓗᛮ⪃ࡣ㌟య⑕≧࡟ᙳ㡪ࢆཬࡰࡍせᅉࡢ୍ࡘ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋᮏ◊
✲࡛ࡣࡑࡢㄪᰝࢆ┠ⓗ࡜ࡋࡓ㸳ᅉᏊ 㡯┠࠿ࡽ࡞ࡿࠕ㌟యឤぬ࡟ᑐࡍࡿ◚ᒁⓗᛮ⪃ᑻᗘࠖ
ࢆ⏝࠸ࡓࠋྛᅉᏊࡣࠕ㌟యឤぬ࡟ᑐࡍࡿὀពࠖࠕ᪥ᖖ⏕άୖࡢᨭ㞀ࠖࠕ㔜⠜࡞⑓Ẽࡢᠱᛕࠖ
ࠕ⑕≧࡟ᑐࡍࡿ↓ຊឤࠖ࠾ࡼࡧࠕ⤯ᮃឤ࡛ࠖ࠶ࡿࠋ
ᮏ◊✲࡛ࡣ㞴἞ᛶࡵࡲ࠸ᝈ⪅ࢆᑐ㇟࡜ࡋ࡚ᝈ⪅ࡢ♫఍ⓗ⫼ᬒࢆྵࡵࡓ⮬グᘧ㉁ၥ⣬ࢆ⏝࠸
ࡵࡲ࠸ࡢ㔜⑕໬࡟࠾ࡅࡿᚰ⌮ⓗせᅉ࡟ࡘ࠸᳨࡚ウࢆ⾜ࡗࡓࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
㒔ෆ༢୍་⒪᪋タ⪥㰯ဗႃ⛉እ᮶࡟࡚ ࣧ᭶௨ୖ୍⯡ⓗ἞⒪ࢆ⾜ࡗࡓ࡟ࡶ࠿࠿ࢃࡽࡎࡵ
ࡲ࠸⑕≧ࡀ㑄ᘏࡋࡓᝈ⪅ࡢ࠺ࡕ ᖺ ᭶࠿ࡽ ᭶ࡢ㛫࡟ධ㝔࡟ࡼࡿ✚ᴟⓗ࡞἞⒪ࢆ
― 57 ―
ᕼᮃࡋࡓ㞴἞ᛶᮎᲈᛶࡵࡲ࠸ 210 ౛(ዪ 75%, ᖹᆒᖺ㱋 65 ṓ)ࢆᑐ㇟࡜ࡋࡓࠋ᳨ウࡋࡓ㡯
┠ࡣᛶู,ᖺ㱋,ᑵປࡢ᭷↓(↓⫋㸭ᑵປ),᭱⤊ᏛṔ(▷኱௨ୗ㸭኱Ꮫ௨ୖ),ᚰ⌮ᑻᗘ࡛࠶ࡿࠋᚰ
⌮ᑻᗘ࡟ࡣ,(a)㌟యឤぬ࡟ᑐࡍࡿ◚ᒁⓗᛮ⪃ᑻᗘ(Somatosensory Catastrophizing Scale,
SSCS), (b) ㌟ య ឤ ぬ ቑ ᖜ ᑻ ᗘ (Somatosensory Amplification Scale), (c) ㌟ య ⑕ ≧ ホ ౯
(Medical Symptom Checklist), (d) ⮬ᕫホᐃᘧᢚ࠺ࡘᑻᗘ(Self-rating Depression Scale,
SDS)ࡢࡑࢀࡒࢀ࡟ࡘ࠸࡚⮬グᘧ㉁ၥ⣬ࢆ⏝࠸࡚ᑜࡡࡓࠋࡵࡲ࠸ࡢ㢖ᗘࢆ㐌࡟୍ᅇ௨ୖࢆࡵ
ࡲ࠸㔜ᗘ⩌,ࡑࢀᮍ‶ࢆࡵࡲ࠸㍍ᗘ⩌࡜ᐃ⩏ࡋ,ࡑࢀࡒࢀࡢᅉᏊ࡜ࡢ㛵㐃ࢆ⤫ィᏛⓗ࡟᳨ウ
ࡋࡓࠋ
⤖ ᯝ
ࡵࡲ࠸㍍ᗘ⩌࡟ẚ࡭࡚,ࡵࡲ࠸㔜ᗘ⩌ࡣ᭷ព࡟ⱝࡃ(p=0.001),ᑵປࡋ࡚࠾ࡾ(p=0.001),᭱
⤊ᏛṔࡣ኱Ꮫ௨ୖ࡛࠶ࡗࡓ(p=0.013)ࠋࡲࡓ,ᚰ⌮ᑻᗘࡢ SSCS (p<0.0001)࡞ࡽࡧ࡟ SDS
(p=0.049)ࡢᖹᆒⅬࡣࡵࡲ࠸㔜ᗘ⩌ࡀ㍍ᗘ⩌ࡼࡾࡶ᭷ព࡟㧗࠿ࡗࡓࠋࡵࡲ࠸ࡢ㔜⑕ᗘ࡟ᙳ㡪
ࡍࡿᅉᏊࢆ᳨ウࡍࡿࣟࢪࢫࢸ࢕ࢵࢡᅇᖐศᯒ࡛ࡣㄝ᫂ኚᩘ࡜ࡋ࡚ SSCS ࡢྜィ್ࢆᢞධࡋ
ࡓࣔࢹࣝ㸯࡜ SSCS ࡢྛᅉᏊࡢ್ࢆᢞධࡋࡓࣔࢹࣝ㸰ࢆ⾜࠸,ᑵປࡋ࡚࠸࡞࠸ሙྜ࡟ẚ࡭ᑵ
ປࡋ࡚࠸ࡿ࡜ࡵࡲ࠸ࡣ 3 ಸ㔜⑕໬ࡋࡸࡍࡃ(ࣔࢹࣝ 1 OR 3.47,95%CI:1.51-8.00; ࣔࢹࣝ 2
OR 3.18, 95%CI:1.36-7.45),ࣔࢹࣝ㸯࡟࡚ SSCS ࡢྜィⅬࡀ 1 Ⅼୖ᪼ࡍࡿࡈ࡜࡟ࡵࡲ࠸ࡣ
3㸣(95%CI: 1.01-1.05)㔜⑕࡟ഴࡁࡸࡍ࠸ഴྥࢆ,ࣔࢹࣝ㸰࡟࡚ SSCS ࡢ➨஧ᅉᏊ㸦⏕άୖࡢ
ᨭ㞀㸧ࡀ 1 Ⅼୖ᪼ࡍࡿࡈ࡜࡟ࡵࡲ࠸ࡣ 11%㔜⑕໬࡟㌿ࡌࡿഴྥ(OR 1.11, 95%CI:1.03-1.19)
ࢆㄆࡵࡓࠋ
― 58 ―
― 59 ―
㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿࣄࢺங㢌⭘࢘࢖ࣝࢫ㸦+39㸧ࡢ㛵୚
ᚨ୸ ⿱ࠊ⸨஭ṇே
⫈ぬᖹ⾮ぬ◊✲㒊
せ⣙
Ḣ⡿࡛ࡣᛶάືࡢከᵝ໬ࠊάⓎ໬࡟క࠸ +39 ࡟㛵㐃ࡋࡓ୰ဗ㢌⒴ࡀቑຍഴྥ࡟࠶ࡿࠋ௒
ᚋࠊᮏ㑥࡟࠾࠸࡚ࡶḢ⡿ࡢὶࢀࢆ㏣㝶ࡋࠊ+39 㛵㐃୰ဗ㢌⒴ࡀቑຍࡍࡿ࡜⪃࠼ࡽࢀࡿࠋ+39
㛵㐃ࡢ୰ဗ㢌⒴ࡣ㠀ႚ↮⪅ࡸẚ㍑ⓗⱝᖺ⪅࡟ከࡃⓎ⏕ࡋࠊࡲࡓணᚋࡀⰋዲ࡛࠶ࡿ࡞࡝ࠊࡇ
ࢀࡲ࡛ࡢ㢌㢕㒊⒴࡜ࡣ␗࡞ࡿ⮫ᗋീࢆ࿊ࡍࡿࠋ+39 㝧ᛶࡢ୰ဗ㢌⒴ࡣࠊᚑ᮶ࡢ㢌㢕㒊⒴࡜ࡣ
␗࡞ࡿⓎ⒴࣓࢝ࢽࢬ࣒࡟ࡼࡗ࡚Ⓨ⏕ࡋࡓ࡜⪃࠼ࡽࢀࠊࡇࢀࡽࡢ୰ဗ㢌⒴⑕౛࡟ᑐࡋ࡚ࡣࠊ
᪂ࡓ࡞἞⒪ᡓ␎ࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋ
⫼ᬒࠊ┠ⓗ
ࣄࢺங㢌⭘࢘࢖ࣝࢫ㸦KXPDQSDSLOORPDYLUXV+39㸧ࡣࣃ࣏ࣂ࢘࢖ࣝࢫ࡟ᒓࡍࡿ࢘࢖ࣝࢫ
࡛ࠊṇ஧༑㠃యᵓ㐀ࡢ࢟ࣕࣉࢩࢻᵓ㐀ෆ࡟஧ᮏ㙐⎔≧ '1$ ࢆࢤࣀ࣒࡜ࡋ࡚ᣢࡗ࡚࠾ࡾࠊ
✀㢮௨ୖࡢᆺࡀ▱ࡽࢀ࡚࠸ࡿࠋ኱ࡁࡃపࣜࢫࢡ⩌࡜㧗ࣜࢫࢡ⩌࡟ศ㢮ࡉࢀࠊపࣜࢫࢡ⩌࡟
ࡣࢱ࢖ࣉ 㸪ࠊ㸪㸪 ࡞࡝ࡀᒓࡋࠊ␼ࡸᑤᆂࢥࣥࢪ࣮࣐ࣟࡢⓎ⏕࡟㛵㐃ࡋ࡚࠸ࡿࠋ
୍᪉ࠊ㧗ࣜࢫࢡ⩌࡟ࡣࢱ࢖ࣉ 㸪㸪ࠊ㸪ࠊ࡞࡝ࡀྵࡲࢀࠊࡑࡢᣢ⥆ឤᰁࡣᏊᐑ㢕
⒴࡞࡝ࡢᝏᛶ⭘⒆ࡢཎᅉ࡟࡞ࡿ࡜ࡉࢀ࡚࠸ࡿ㸯㸧ࠋ㢌㢕㒊⒴࡜ +39 ࡜ࡢ㛵㐃࡟ࡘ࠸࡚ࡣ௨๓
ࡼࡾ♧ࡉࢀ࡚ࡁࡓࡀࠊ᭱㏆ࡢႚ↮⋡ࡸ㣧㓇㔞ࡢపୗ࡟క࠸ࠊᨵࡵ࡚ +39 㛵㐃ࡢ㢌㢕㒊⒴ࠊ
≉࡟୰ဗ㢌⒴ࡀὀ┠ࡉࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁࡓࠋᙜ⛉࡛ຍ⒪ࡋࡓ㢌㢕㒊⒴⑕౛ࢆᑐ㇟࡟㹆㹎
㹔ឤᰁࡢ᳨ウࢆ⾜࠺࡜࡜ࡶ࡟ࠊ୰ဗ㢌⒴࡜㹆㹎㹔ࡢ㛵㐃࡟ࡘ࠸࡚ゝཬࡍࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
ᑐ㇟ࡣᙜ⛉࡟࡚ຍ⒪ࡋࡓ㢌㢕㒊ᡥᖹୖ⓶⒴⑕౛ ౛࡛ࠊཎⓎ㒊఩ู࡛ࡣୗဗ㢌 ౛ࠊ
ႃ㢌 ౛ࠊ୰ဗ㢌 ౛ࠊཱྀ⭍ ౛࡛࠶ࡗࡓ ౛࡜ࡋࡓࠋᛶูࡣ⏨ᛶ ౛ࠊዪᛶ ౛࡛ࠊ
ᖺ㱋ࡢ୰ኸ್ࡣ ṓ࡛࠶ࡗࡓࠋ⑓ᮇศ㢮࡛ࡣࢫࢸ࣮ࢪϩࡀ ౛㸦㸧
ࠊࢫࢸ࣮ࢪϪࡀ ౛
㸦㸧ࠊࢫࢸ࣮ࢪϫࡀ ౛㸦㸧࡜㐍⾜⒴ࡀ኱㒊ศࢆ༨ࡵࡓࠋᡭ⾡ࡶࡋࡃࡣ⏕᳨࡟࡚᥇
ྲྀࡉࢀࡓ᳨యࡣࠊ㏿ࡸ࠿࡟㸫 ᗘ࡛ಖᏑࡋࠊࡑࡢᚋ '1$ ࢆᢳฟࡋࡓࠋ㹆㹎㹔ࡢ᳨ฟ࡜ࢱ࢖
― 60 ―
ࣆࣥࢢࡣ 3&5+XPDQ3DSLOORPDYLUXV'HWHFWLRQ6HW ࠾ࡼࡧ 3&5+XPDQ3DSLOORPDYLUXV7\SLQJ
6HWඹ࡟ࢱ࢝ࣛࣂ࢖࢜ᰴᘧ఍♫ࢆ⏝࠸ࡓࠋ'HWHFWLRQVHW ࡛ࡣ㹆㹎㹔ࠊࠊ࠾ࡼࡧ ᆺ
ࢆࡑࢀࡒࢀ≉␗ⓗ࡟ቑᖜࡍࡿࣉࣛ࢖࣐࣮ࢆ⏝࠸࡚㹎㹁㹐ࢆ⾜࠸ࠊ㹆㹎㹔ࢆ᳨ฟࡋࡓࠋࡲࡓ
7\SLQJ6HW ࡛ࡣࡲࡎ㹆㹎㹔ࡢ ( ࡜ ( ࢆྵࡴ㡿ᇦ㸦㹼ES㸧ࢆࢥࣥࢭࣥࢧࢫࣉࣛ࢖࣐
࣮࡟࡚ቑᖜࡋࡓࠋቑᖜࡉࢀࡓ '1$ ࣇࣛࢢ࣓ࣥࢺࡣᩘ✀㢮ࡢไ㝈㓝⣲࡛ฎ⌮ࡋࠊࡑࡢ㟁ẼὋ
ືࣃࢱ࣮ࣥ࡟ࡼࡾ㹆㹎㹔ࡢࢱ࢖ࣉࢆุูࡋࡓࠋ
㧗ࣜࢫࢡ㹆㹎㹔࡛࠶ࡿࢱ࢖ࣉ ࠾ࡼࡧపࣜࢫࢡ㹆㹎㹔࡛࠶ࡿࢱ࢖ࣉ ࡢྜィ ✀㢮ࡢ㹆㹎㹔ࡀ᳨ฟྍ⬟࡛
࠶ࡿࠋ
⤖ ᯝ
ᑐ㇟⑕౛ ౛୰ࠊ ౛㸦㸧࡟㹆㹎㹔ࡢឤᰁࢆㄆࡵࠊ࠸ࡎࢀࡶ୰ဗ㢌⒴࡛࠶ࡗࡓࠋ୰ဗ
㢌⒴ࡢࡳ࡛ࡣ ౛୰ ౛㸦㸧࡟㹆㹎㹔ࡀ᳨ฟࡉࢀࡓࠋ㹆㹎㹔ࡢࢱ࢖ࣆࣥࢢࡢ⤖ᯝࡣࢱ
࢖ࣉ ࡀ ౛ࠊࢱ࢖ࣉ ࡀ ౛࡛࠶ࡗࡓࠋ㹆㹎㹔ឤᰁࡢ᭷↓࡜⭘⒆ࡢள㒊఩࡜ࡢ㛵ಀࢆ
ࡳ࡚ࡳࡿ࡜ࠊ㹆㹎㹔㝧ᛶ୰ဗ㢌⒴࡛ࡣཱྀ⵹ᡥ᱈ ౛ࠊ⯉᰿ ౛࡛࠶ࡗࡓࡀࠊ㝜ᛶ⑕౛ࡣཱྀ
⵹ᡥ᱈ ౛ࠊ⯉᰿ ౛࡛ࠊࡑࡢ௚ࡢ ౛ࡣᚋቨࠊ㌾ཱྀ⵹࡛࠶ࡗࡓࠋࡇࢀࡲ࡛ࡢሗ࿌࡜ྠᵝࠊ
ཱྀ⵹ᡥ᱈࡜⯉᰿ࡀ㹆㹎㹔ឤᰁ࡜ᙉ࠸㛵㐃ࡀ࠶ࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋႚ↮≧ែ࡜ࡢ㛵㐃ࢆぢࡿ
࡜ࠊ㹆㹎㹔㝧ᛶ⑕౛ࡣ㠀ႚ↮⪅ࡀ ౛ࠊႚ↮⪅ࡶࡋࡃࡣ㐣ཤࡢႚ↮⪅ࡀ ౛࡛࠶ࡗࡓࡀࠊ
㹆㹎㹔㝜ᛶ⑕౛࡛ࡣ㠀ႚ↮⪅ࡀ ౛ࠊႚ↮⪅ࡶࡋࡃࡣ㐣ཤࡢႚ↮⪅ࡀ ౛࡛࠶ࡗࡓࠋ㹆㹎
㹔㝧ᛶ⑕౛ࡣ᭷ព࡟㠀ႚ↮⪅ࡀከ࠸ഴྥࡀㄆࡵࡽࢀࡓࠋࡲࡓ㹆㹎㹔ឤᰁࡢ᭷↓࡜㹒ศ㢮ࠊ
㹌ศ㢮ࠊ⑓ᮇศ㢮࡜ࡢ㛵㐃ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࠋ
⪃ᐹࠊ௒ᚋࡢ᳨ウㄢ㢟
ࣄࢺங㢌⭘࢘࢖ࣝࢫ㸦+39㸧ࡣࣄࢺ࡟ᐜ᫆࡟ឤᰁࡍࡿࡓࡵࠊዪᛶࡢ⣙ ̺ࡣ୍⏕ࡢ࠺
ࡕ୍ᗘࡣᛶჾ࡟ +39 ឤᰁࡀ⏕ࡌࡿ࡜ࡉࢀ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊከࡃࡢሙྜࡣ⮬ᕫࡢච␿
ຊ࡛᤼㝖ࡉࢀ⣙ 㸫ࡀᣢ⥆ឤᰁ࡜࡞ࡾࠊᩘᖺ࠿ࡽ ᩘᖺᚋ࡟㧗ᗘࡢ⣽⬊␗ᆺࢆ㉳ࡇࡍ
ࡢࡣ ⛬ᗘ࡛࠶ࡿࠋ᭱⤊ⓗ࡟Ꮚᐑ㢕⒴ࡲ࡛⮳ࡿࡢࡣឤᰁ⪅ࡢ⣙ 㸣⛬ᗘ࡜ࡉࢀ࡚࠸ࡿࠋ
ࡇࡢࡼ࠺࡟኱㒊ศࡢ +39 ឤᰁࡀ୍㐣ᛶឤᰁ࡟⤊ࢃࡿࡢࡣࠊ1. ⣽⬊ࡸ࣐ࢡࣟࣇ࢓࣮ࢪ࡞࡝ࡢ
⣽⬊࡜ࠊ࢖ࣥࢱ࣮ࣇ࢙ࣟࣥ࡞࡝ࡢࢧ࢖ࢺ࢝࢖ࣥࡀᶵ⬟ࡋ࡚⏕ࡌࡿᐟ୺ࡢච␿ᛂ⟅࡟ࡼࡿࠋ
㧗ࣜࢫࢡ +39 ࡀᐟ୺⣽⬊ࡢ '1$ ࡟⤌ࡳ㎸ࡲࢀࡿ࡜ࠊ+39 ࡢ୰ࡢ ( 㑇ఏᏊࡀษ᩿ࡉࢀࠊࡑ
ࡢ ( 㑇ఏᏊ࡟ࡼࡾⓎ⌧ࡀᢚไࡉࢀ࡚࠸ࡓࠊ+39 ⏤᮶ࡢ⒴⺮ⓑ (ࠊ( ࡀ㧗Ⓨ⌧ࡍࡿࠋ(ࠊ(
ࡣࠊ⒴ᢚไ㑇ఏᏊ࡜ࡋ࡚᭷ྡ࡞ S ࡸ5E ࡜࠸ࡗࡓ㑇ఏᏊࡢാࡁࢆ୙ά໬ࡍࡿࡓࡵࠊࡑࡢ⤖
ᯝࠊ⒴໬࡟ࡘ࡞ࡀࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋࡑࡢ௚ࠊ࢔࣏ࢺ࣮ࢩࢫࡢᢚไࠊࢸ࣓ࣟ࢔ࡢቑ㛗ࠊ
⣽⬊ቑṪࡢஹ㐍࡞࡝ࡢ⒴໬࡟㛵㐃ࡋࡓാࡁࡶሗ࿌ࡉࢀ࡚࠸ࡿࠋ
― 61 ―
㢌㢕㒊⒴࡜ +39 ࡜ࡢ㛵㐃࡟ࡘ࠸࡚ࡣᮏ㑥࡟࠾࠸࡚ࡶ௨๓ࡼࡾ♧ࡉࢀ࡚ࡁࡓࡀࠊ᭱㏆ࡢႚ
↮⋡ࡸ㣧㓇㔞ࡢపୗ࡟క࠸ࠊᨵࡵ࡚ +39 㛵㐃ࡢ㢌㢕㒊⒴ࠊ≉࡟୰ဗ㢌⒴ࡀὀ┠ࡉࢀࡿࡼ࠺
࡟࡞ࡗ࡚ࡁࡓࠋ࡜࠸࠺ࡢࡶḢ⡿ࢆ୰ᚰ࡜ࡋ࡚ࠊ+39 ࡀ㝧ᛶ࡛࠶ࡿ୰ဗ㢌⒴ࡢⓎ⏕⋡ࡀୖ᪼ࡋ
࡚࠸ࡿ࠿ࡽ࡛࠶ࡿࠋࡑࡢ⌮⏤࡜ࡋ࡚ࡣࠊⱝᖺ⪅ࡢᛶάືࡢάⓎ໬ࠊከᵝ໬ࡀᣲࡆࡽࢀ࡚࠾
ࡾࠊYDJLQDOVH[SDUWQHUV ࡸ RUDOVH[SDUWQHU ࡢᩘ࡜ +39 ឤᰁ⋡ࡸ୰ဗ㢌⒴ࡢⓎ⏕⋡
࡜ࡢ┦㛵ࡀ♧ࡉࢀ࡚࠸ࡿࠋࡲࡓࢫ࢙࣮࢘ࢹࣥ࡟࠾࠸࡚ࡶཱྀ⵹ᡥ᱈ཎⓎࡢᡥᖹୖ⓶⒴ࡀᛴቑ
ࡋ࡚࠾ࡾࠊ+39 ࡢ㝧ᛶ⋡ࡶࡲࡓୖ᪼ࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋ
ࡇࢀࡽࡢ +39 㛵㐃㢌㢕㒊⒴ࡣࡇࢀࡲ࡛ࡢ㢌㢕㒊⒴࡜ẚ㍑ࡋࠊ࠸ࡃࡘ࠿ࡢ⮫ᗋୖࡢ≉ᚩࡀ
࠶ࡿࠋ౛࠼ࡤ +39 㝧ᛶ㢌㢕㒊⒴ᝈ⪅ࡣࠊ㠀ႚ↮⪅࡛ẚ㍑ⓗⱝᖺ⪅࡟Ⓨ⏕ࡍࡿࡇ࡜ࡸணᚋࡀ
Ⰻዲ࡛࠶ࡿࡇ࡜࡞࡝ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋணᚋࡀⰋዲ࡛࠶ࡿ⌮⏤ࡣࡣࡗࡁࡾ࡜ࡣゎ᫂ࡉࢀ࡚
࠸࡞࠸ࡀࠊ+39 㝧ᛶ㢌㢕㒊⒴࡛ࡣ ILHOGFDQFHUL]DWLRQ ࡀ⏕ࡌ࡚࠾ࡽࡎ㔜」⒴ࡀⓎ⏕ࡋ࡟ࡃ
࠸ࡇ࡜ࡸࠊ⒴ᢚไ㑇ఏᏊ࡛࠶ࡿ S ࡀ ( ࡛ᢚไࡉࢀ࡚࠸ࡿࡶࡢࡢࡑࡢ㑇ఏᏊኚ␗ࡀᑡ࡞ࡃ
㸧ࠊ໬Ꮫ⒪ἲࡸᨺᑕ⥺἞⒪࡟ᑐࡍࡿឤཷᛶࡀ㧗࠸ࡇ࡜࡞࡝ࡀ⪃࠼ࡽࢀ࡚࠸ࡿࠋ+39 㛵㐃㢌
㢕㒊⒴࡛ࡣࠊᚑ᮶࠿ࡽᥦၐࡉࢀ࡚ࡁࡓⓎ⒴࣓࢝ࢽࢬ࣒࡜ࡣ␗࡞ࡿᶵᗎࡀാ࠸࡚࠾ࡾ⮫ᗋⓗ
࡟ࡶ⏕≀Ꮫⓗ࡟ࡶᚑ᮶ࡢ㢌㢕㒊⒴࡜ࡣ␗࡞ࡿ≉ᚩࢆ♧ࡋ࡚࠸ࡿࠋ
௒ᚋࠊᮏ㑥࡟࠾࠸࡚ࡶ⡿ᅜ࡛ࡢഴྥࢆ㏣ᚑࡋ +39 㛵㐃ࡢ㢌㢕㒊⒴ࡀቑຍࡍࡿࡇ࡜ࡀண᝿
ࡉࢀࠊ⌧᫬Ⅼ࡛ࡢ +39 ឤᰁࡢ㢖ᗘࡸࢱ࢖ࣆࣥࢢࢆ᳨ウࡍࡿࡇ࡜ࡣ㔜せ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋ
ᡃࠎࡣᙜ⛉࡟࡚἞⒪ࢆ⾜ࡗࡓ㢌㢕㒊⒴࡟ࡘ࠸࡚ +39 ឤᰁࡢ᭷↓ࢆ᳨ウࡋࡓࡀࠊ⤖ᯝࡣ୰ဗ
㢌⒴ࡢࡳ࡟ +39 㝧ᛶ⑕౛ࡀㄆࡵࡽࢀࠊࡑࡢ㢖ᗘࡣ ࡛࠶ࡗࡓࠋ㢌㢕㒊⒴ࡢ +39 ឤᰁ࡟ࡘ࠸
࡚ࡣࠊႃ㢌⒴ࡸཱྀ⭍⒴࡛ࡢ᳨ฟࡶሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊ᭱㏆࡛ࡣ࡯࡜ࢇ࡝ࡀ୰ဗ㢌⒴࡟࠾ࡅ
ࡿሗ࿌ࡀከ࠸ࠋࡲࡓᡃࠎࡢ +39 ࢱ࢖ࣆࣥࢢࡢ⤖ᯝࡣ኱㒊ศࡢ⑕౛ࡀ +39 ࡛࠶ࡾࠊࡑࢀ௨
እ࡛ࡣࢱ࢖ࣉ ࡀ ౛ㄆࡵࡽࢀࡓࡔࡅ࡛࠶ࡗࡓࠋ+39 ࡢࢱ࢖ࣉࡣ ✀㢮௨ୖࡀ▱ࡽࢀ࡚
࠸ࡿࡀࠊⓎ⒴࡜㛵㐃ࡋ࡚࠸ࡿࡢࡣ࠸ࢃࡺࡿ㧗ࣜࢫࢡ⩌࡟ศ㢮ࡉࢀࡿ +39 ࡛࠶ࡿࠋ୰࡛ࡶ +39
ࡢឤᰁࡀ኱㒊ศࢆ༨ࡵ࡚࠾ࡾࠊ⡿ᅜ࡛ࡢሗ࿌࡛ࡣ㢌㢕㒊⒴᳨࡛ฟࡉࢀࡿ +39 ࡣ ௨ୖࡀ
+39 ࡛࠶ࡿࠋ+39 ࡢឤᰁ࡜㛵㐃ࡀ῝࠸Ꮚᐑ㢕⒴ࡢሙྜࡣࠊ⡿ᅜ࡛ࡣ +39ࠊ ࡢឤᰁࡀ኱
㒊ศࢆࡋࡵࡿࡀࠊᮏ㑥࡛ࡣ 㸪 ࡢࡳ࡞ࡽࡎ 㸪ࠊ㸪 ࡜࠸ࡗࡓ௚ࡢ㧗ࣜࢫࢡࢱ࢖
ࣉࡢ +39 ࡶẚ㍑ⓗ㢖ᗘࡀ㧗ࡃ᳨ฟࡉࢀ࡚࠸ࡿࠋ+39 㛵㐃ࡢ㢌㢕㒊⒴ࡀᛶάື࡜ᐦ᥋࡞㛵㐃ࡀ
࠶ࡿࡢ࡛࠶ࢀࡤࠊᮏ㑥ࡢ㢌㢕㒊⒴࡟࠾ࡅࡿ +39 ࡢࢱ࢖ࣉࡣᏊᐑ㢕⒴ࡢࢱ࢖ࣉูࡢ๭ྜ࡜ྠ
➼ࡢศᕸࢆ♧ࡍ࡜᥎ ࡉࢀࡿࠋ௒ᚋࡢከ᪋タ࡛ࡢゎᯒࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋ
᭱㏆࡟࡞ࡾ +39 㝧ᛶ୰ဗ㢌⒴ࡢணᚋࡀⰋዲ࡛࠶ࡿ࡜ࡢሗ࿌ࡀ⥆࠸࡚࠸ࡿࠋ௒ᚋࡢࡉࡽ࡞
ࡿ᳨ウ࡟ࡼࡗ࡚ࠊ+39 ឤᰁࡢ᭷↓࡜㸦໬Ꮫ㸧ᨺᑕ⥺἞⒪࡟ᑐࡍࡿឤཷᛶࡸணᚋ࡞࡝࡜ࡢ㛵㐃
ࡀ᫂☜࡟࡞ࢀࡤࠊ+39 ឤᰁࡢ≧ែࡀ἞⒪᪉㔪ࢆỴᐃࡍࡿୖ࡛㔜せ࡞ࣂ࢖࣐࣮࣮࢜࢝࡟࡞ࡿྍ
⬟ᛶࡀ࠶ࡿࠋࡲࡓ +39 ᳨ᰝࡢಖ㝤㐺ᛂࡸࡼࡾ⡆౽࡛౵くࡢᑡ࡞࠸᳨ฟ᪉ἲࡢ㛤Ⓨ࡞࡝࡟ࡘ
࠸࡚ࡶ᳨ウࡍࡿ࡭ࡁ࡜⪃࠼ࡽࢀࡿࠋ
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⫈ぬᖹ⾮ぬ◊✲㒊
㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿࡀࢇᖿ⣽⬊ᵝ⣽⬊࣐࣮࣮࢝ࡢⓎ⌧࡜ࡑࡢ
⮫ᗋⓗព⩏࡟㛵ࡍࡿ᳨ウ
-StageϨ/ϩ⯉ᡥᖹୖ⓶⒴࡟࠾ࡅࡿᚋⓎ㢕㒊ࣜࣥࣃ⠇㌿⛣࡟࠾࠸࡚⩚⏕᪼ ⸨஭ṇே㸦⫈ぬᖹ⾮ぬ◊✲㒊㸧
࠙せ⣙ࠚ
㏆ᖺ⒴ᖿ⣽⬊ࡢᴫᛕࡀᥦၐࡉࢀࠊ㢌㢕㒊⒴࡟᪊࠸࡚ࡶ Side Population㸦SP㸧⣽⬊ࡣࠊ
⒴ᖿ⣽⬊ࢆከࡃྵࢇࡔ⣽⬊࡜ሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊࡑࡢᙺ๭ࡣ༑ศ࡟ゎ᫂ࡉࢀ࡚࠸࡞࠸ࠋ
⒴ᖿ⣽⬊ࡣ἞⒪᢬ᢠᛶࠊ෌Ⓨࠊ㌿⛣࡟㛵୚ࡋ࡚࠸ࡿ࡜࠸ࢃࢀ࡚࠸ࡿࠋ
StageϨ/ϩ⯉⒴ࡣࠊ㏻ᖖ⯉㒊ศษ㝖⾡ࡀ⾜ࢃࢀࡿࡀࠊࡑࡢ࠺ࡕ⣙ 14-48㸣࡟ཎⓎᕢࡣไ
ᚚࡉࢀ࡚࠸ࡿ࡟ࡶ࠿࠿ࢃࡽࡎࠊᚋⓎ㢕㒊ࣜࣥࣃ⠇㌿⛣ࡀ⏕ࡌࡿࠋᚋⓎ㢕㒊ࣜࣥࣃ⠇ࡣ⏕
Ꮡ⋡ࢆపୗࡉࡏࡿࠋ
ᚋⓎ㢕㒊ࣜࣥࣃ⠇㌿⛣࡟࠾࠸࡚⒴ᖿ⣽⬊࡜ࡢ㛵㐃࡟ࡘ࠸᳨࡚ウࡋࡓࠋ
ࡑࡇ࡛ᡃࠎࡣձ⯉ᡥᖹୖ⓶⒴⣽⬊ᰴ࡟࠾ࡅࡿ SP ⣽⬊ࡢ᭷↓㸪ղSP ⣽⬊࡟࠾ࡅࡿ⒴ᖿ
⣽⬊㛵㐃㑇ఏᏊࡢⓎ⌧㸪ճSP ⣽⬊ࡢᶵ⬟࡜ࡋ࡚ࠊቑṪ⬟࣭㐟㉮⬟࣭ᾐ₶⬟, մ⯉⒴⮫ᗋ
᳨య࡟࠾ࡅࡿྠ㛵㐃㑇ఏᏊࡢⓎ⌧࡜ࡑࡢ⮫ᗋⓗព⩏࡟ࡘ࠸᳨࡚ウࡋࡓࠋ
࠙ᑐ㇟࠾ࡼࡧ᪉ἲ࣭⤖ᯝࠚ
ձ DNA ⤖ྜⰍ⣲ Hoechst33342 ࢆ⏝࠸⯉⒴ᡥᖹୖ⓶⒴⣽⬊ᰴ(SAS,HSC4,SCC4)ࢆ
flowcytometry ࡟࡚ sorting ࡋࡓ⤖ᯝ㸪SP ࡣ SAS ࡟࡚ 0.9㸣ࠊHSC4 ࡟࡚ 0.9%ࠊSCC
㸲࡟࡚ 10.2㸣ࠊࡑࢀࡒࢀㄆࡵࡽࢀࡓࠋABC transporter 㜼ᐖ๣࡟࡚ࡑࢀࡒࢀ SP ࡢ๭
ྜࡀⴭ᫂࡟ῶᑡࡍࡿࡇ࡜࠿ࡽ⒴ᖿ⣽⬊ᵝ⣽⬊࡜⪃࠼ࡽࢀࡓࠋ
ղ SCC4 ࡢ SP ⣽⬊࡜ non SP ⣽⬊ࢆ Microarray ࡟࡚ゎᯒࡋࡓࠋSP ⣽⬊࡛ࡣ
Oct3/4,Ntohc1,CD44,ABCG2 ࡀ non SP ⣽⬊ࡼࡾⓎ⌧ࡀ㧗࠿ࡗࡓࠋࡘࡂ࡟ RT-PCR
࡟࡚⒴ᖿ⣽⬊㛵㐃㑇ఏᏊࡢⓎ⌧ࢆ SCC4 ࡢ SP ⣽⬊࡜ non SP ⣽⬊ࡢ㛫࡛ẚ㍑ࡋࡓ⤖
ᯝࠊSP ⣽⬊࡛㌿෗ᅉᏊ Oct3/4ࠊNanog ࡢⓎ⌧ࡀ㧗ࡃ㸦ᅗ㸯㸧ࠊච␿⤌⧊໬ᏛᰁⰍ࡟
࡚ࡶྠᵝࡢ⤖ᯝࡀ♧ࡉࢀࡓࠋ
ճ SCC4 ࡢ SP ⣽⬊࡜ non SP ⣽⬊ࡢ㛫࡛ࠊ㸲㸶᫬㛫࡟࠾ࡅࡿ proliferation assay,
migration assay, invasion assay ࢆ⾜࠸ࠊẚ㍑ࡋࡓࠋ⣽⬊ቑṪ⬟࡟᫂ࡽ࠿࡞᭷ពᕪࡣ
ㄆࡵ࡞࠿ࡗࡓࠋ㐟㉮⬟࡜ᾐ₶⬟ࡣ SP ⣽⬊ࡀඃ఩࡟㧗࠿ࡗࡓࠋ
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մ ៞᠕⩏ሿ኱Ꮫ⑓㝔⪥㰯ဗႃ⛉࡛ึᅇ἞⒪࡜ࡋ࡚⯉㒊ศษ㝖ࡢࡳࢆ⾜࠸ࠊ3 ᖺ௨ୖ⤒㐣
ほᐹࡋࡓ stage I/II ⯉ᡥᖹୖ⓶⒴౛ࡢ࠺ࡕཎⓎᕢᶆᮏࢆධᡭࡋ࠼ࡓ 50 ౛ࢆᑐ㇟࡟ࠊ
Oct3/4 ࡜ Nanog ࡢⓎ⌧ࢆච␿ᰁⰍ࡟࡚ホ౯ࡋ㸪ᚋⓎ㢕㒊ࣜࣥࣃ⠇㌿⛣(delayed neck
metastasis: DNM)࡜ࡢ㛵ಀ࡟ࡘ࠸᳨࡚ウࡋࡓࠋDNM ࡣ 13 ౛(267%)࡟ㄆࡵࡽࢀࠊ
Oct3/4ࠊNanog ࡢⓎ⌧࡜ࡢ㛫࡟ṇࡢ┦㛵ࡀㄆࡵࡽࢀࡓࠋ⮫ᗋ⑓⌮ᏛⓗᅉᏊ࡜ DNM ࡛
ࡣ, muscular invasion, vascular invasion, Mode of invasion(3.4 v.s 1.2)ࡀṇࡢ┦㛵
ࡀㄆࡵࡽࢀࡓࠋ༢ኚ㔞ゎᯒ࡛┦㛵ࡀㄆࡵࡽࢀࡓ Oct3/4 expression, Nanog expression,
Mode of invasion, vascular invasion, muscular invasion ࢆ logistic regression ࡟ࡼ
ࡿከኚ㔞ゎᯒࢆ⾜࠺࡜ࠊDNM ࡟ᑐࡍࡿ⊂❧┦㛵ᅉᏊࡣ Oct3/4 expression ࡜
vascular invasion ࡛࠶ࡗࡓ(ᅗ㸰)ࠋ
࠙⪃ᐹࠚ
㢌㢕㒊⒴ᖿ⣽⬊ࡢᣦᶆ࡜ࡋ࡚ Oct3/4 ࡜ Nanog ࡣ᭷⏝࡞ೃ⿵࡜࡞ࡾ࠺ࡿྍ⬟ᛶࡀ♧၀ࡉ
ࢀࡓࠋࡉࡽ࡟ࡇࢀࡽࡢᣦᶆࢆⓎ⌧ࡍࡿ⒴ᖿ⣽⬊ᵝ⣽⬊ࡢᏑᅾࡀࠊ⣽⬊㐟㉮⬟࠾ࡼࡧᾐ₶
⬟ࡢஹ㐍ࢆ௓ࡋ࡚ࠊstage I/II ⯉ᡥᖹୖ⓶⒴ࡢ DNM ࡟ᐤ୚ࡋ࡚࠸ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ
ᅗ㸯
― 64 ―
ᅗ㸰
― 65 ―
㹙⫈ぬᖹ⾮ぬ◊✲㒊㹛
ࢹࢢ࢚ࣜࣥࡣ㢌㢕㒊ᡥᖹୖ⓶⒴⣽⬊ᰴ࡟࠾࠸࡚ EGFR ࢖ࣥࣄࣅࢱ࣮ࡢᢠ⭘⒆ຠ
ᯝࢆቑ኱ࡉࡏࡿ
㤿ሙඃ ⸨஭ṇே
㸦⫈ぬᖹ⾮ぬ◊✲㒊㸧
せ⣙
㢌㢕㒊ᡥᖹୖ⓶⒴࡛ࡣࠊEGFR ࡀ㧗Ⓨ⌧ࡋ࡚࠾ࡾࠊࡲࡓ EGFR ࡢ㧗Ⓨ⌧࡜ணᚋ࡜ࡢ┦㛵
㛵ಀࡀゝࢃࢀ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊEGFR ࢖ࣥࣄࣅࢱ࣮༢๣࡛ࡢዌຠ⋡ࡣỴࡋ࡚㧗࠸࡜
ࡣ࠸࠼࡞࠸ࠋࡑࡢཎᅉࡢ୍ࡘ࡜ࡋ࡚ࠊEGFR ࡜ IGF1R ࡜ࡢࠊPI3kinase/Akt pathway ࢆ௓
ࡋࡓ cross talk ࡢᏑᅾࡀ⪃࠼ࡽࢀ࠺ࡿࠋࡇࡇ࡛ࠊ
ᡃࠎࡣࠊ࢔ࣇࣜ࢝ࡢ᳜≀ Mundulea sericea
⏤᮶ࡢኳ↛≀࡛࠶ࡿࢹࢢ࢚ࣜࣥࡀ㢌㢕㒊ᡥᖹୖ⓶⒴⣽⬊ᰴ࡟࠾࠸࡚ࠊEGFR ࢖ࣥࣄࣅࢱ࣮
ࡢᢠ⭘⒆ຠᯝࢆቑ኱ࡉࡏࡿࡇ࡜ࢆሗ࿌ࡍࡿࠋ
┠ⓗ
㢌㢕㒊ᡥᖹୖ⓶⒴࡛ࡣࠊEGFR ࡀ㧗Ⓨ⌧ࡋ࡚࠾ࡾࠊࡲࡓ EGFR ࡢ㧗Ⓨ⌧࡜ணᚋ࡜ࡢ┦㛵
㛵ಀࡀゝࢃࢀ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊEGFR ࢖ࣥࣄࣅࢱ࣮༢๣࡛ࡢዌຠ⋡ࡣỴࡋ࡚㧗࠸࡜
ࡣ࠸࠼࡞࠸ࠋࡑࡇ࡛ᡃࠎࡣࠊ㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿ EGFR ࢖ࣥࣄࣅࢱ࣮⪏ᛶᶵᵓࡢゎ
᫂࡜ࡑࡢඞ᭹ἲ࡟ࡘ࠸᳨࡚ウࡋࡓࠋ
᪉ἲ
㸯ࠊ
ᑐ㇟ࡣᙜ⛉࡟࡚ຍ⒪ࡋࡓ㢌㢕㒊ᡥᖹୖ⓶⒴ 86 ౛࡛࠶ࡿࠋᡭ⾡ࡶࡋࡃࡣ⏕᳨࡟࡚᥇
ྲྀࡉࢀࡓ᳨యࡣࠊ㏿ࡸ࠿࡟࣮80 ᗘ࡛ಖᏑࡋࠊࡑࡢᚋ DNA ࢆᢳฟࡋࡓࠋCycleave PCR
ἲ࡟࡚ࠊEGFR sensitive mutation ࡜࠸ࢃࢀ࡚࠸ࡿࠊEGFR ࡢ exon19 ࡢḞኻ࠾ࡼࡧ
L858, G719X, L861Q ࡢⅬ✺↛ኚ␗ࡢ᳨ฟࢆヨࡳࡓࠋ
㸰ࠊ
CycleavePCR ἲ࡟࡚ࠊEGFR resistant mutation ࡜࠸ࢃࢀ࡚࠸ࡿࠊEGFR ࡢ
T790M ኚ␗ࡢ᳨ฟࢆヨࡳࡓࠋ
㸱ࠊ
㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾ࡅࡿ EGFR ࢖ࣥࣄࣅࢱ࣮⪏ᛶᶵᵓࡢゎ᫂࡜ࡑࡢඞ᭹ἲ࡟ࡘ
ࡁࠊ㐣ཤࡢᩥ⊩ࢆᇶ࡟ࠊ௬ㄝ໬ࡋࡓࠋ㸦ᩥ⊩ review㸧
㸲ࠊ
㢌㢕㒊ᡥᖹୖ⓶⒴⏤᮶⣽⬊ᰴ HSC-4 ࢆ⏝࠸࡚ࠊࢹࢢ࢚ࣜࣥࡣ㢌㢕㒊ᡥᖹୖ⓶⒴⣽
⬊ᰴ࡟࠾࠸࡚ EGFR ࢖ࣥࣄࣅࢱ࣮ࡢᢠ⭘⒆ຠᯝࢆቑ኱ࡉࡏࡿ࠿ྰ࠿ࢆ᳨ウࡋࡓࠋ
⤖ᯝ
㸯ࠊ㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾࠸࡚ࠊEGFR sensitive mutation ࡣ᳨ฟࡉࢀ࡞࠿ࡗࡓࠋ㸦0/86㸧
㸰ࠊ㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾࠸࡚ࠊEGFR resistant mutation ࡣ᳨ฟࡉࢀ࡞࠿ࡗࡓࠋ㸦0/86㸧
㸱ࠊ㢌㢕㒊ᡥᖹୖ⓶⒴࡟࠾࠸࡚ࠊEGFR ࡜ IGF1R ࡜ࡢࠊPI3kinase/Akt pathway ࢆ௓ࡋࡓ
cross talk ࡢᏑᅾࡀ EGFR ࢖ࣥࣄࣅࢱ࣮⪏ᛶᶵᵓࡢ୺࡛࠶ࡿ࡜௬ㄝ໬ࡋࡓࠋ
― 66 ―
㸲ࠊ≉␗ⓗ EGFR ࢖ࣥࣄࣅࢱ࣮࡛࠶ࡿ AG1478 ࡣ HSC4 ⣽⬊࡟࠾࠸࡚⇥㓟໬ᆺ AKT ⺮ⓑ
Ⓨ⌧ࢆ᭷ព࡟ࡣῶᑡࡉࡏ࡞࠿ࡗࡓࠋ
㸳ࠊAG1478 ࡜ࢹࢢ࢚ࣜࣥ࡜ࡢే⏝࡟ࡼࡾ⇥㓟໬ᆺ AKT ⺮ⓑⓎ⌧ࡣ᫂ࡽ࠿࡟ῶᑡࡋࠊࡑࢀ
࡟క࠸࢔࣏ࢺ࣮ࢩࢫࡀㄏᑟࡉࢀࡓࠋ
⪃ᐹ
௨ୖࡢ⤖ᯝࡼࡾࠊࢹࢢ࢚ࣜࣥࡣ㢌㢕㒊ᡥᖹୖ⓶⒴⣽⬊ᰴ࡟࠾࠸࡚ EGFR ࢖ࣥࣄࣅࢱ࣮ࡢ
ᢠ⭘⒆ຠᯝࢆቑ኱ࡉࡏࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋ
― 67 ―
>⫈ぬᖹ⾮ぬ◊✲㒊@
⮬ᐙ㦵⨨᥮ᆺ྾཰ᛶேᕤ㦵ࡢຠ⋡ⓗ࡞㦵෌⏕࡟ࡴࡅ࡚
ⴠྜ༤Ꮚ 1ࠊᆏᮏዲ᫛ 2
㸦෌⏕་⒪◊✲ᐊ 1ࠊ៞᠕⩏ሿ኱Ꮫᙧᡂእ⛉Ꮫᩍᐊ 2㸧
せ⣙
ᙜ◊✲ᐊ࡛ࡣࣛࢵࢺࡢ㢌⵹Ḟᦆࣔࢹࣝࢆ㛤Ⓨࡋࠊ2010 ᖺࡼࡾேᕤ㦵⛣᳜ࡢ᭷ຠᛶࡢᐇ㦂
ࢆ⾜࠸ሗ࿌ࡋ࡚ࡁࡓࠋ᫖ᖺࡣࠊ⏕య㦵࡟㏆࠸⤌ᡂࢆᣢࡗࡓࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃࢱ࢖ࢺ㸭ࢥࣛ
࣮ࢤࣥ」ྜయ㸦௨ୗ HA/Col㸧ࡀࠊ㢌⵹㢡㢦㠃㡿ᇦ࡟࠾࠸࡚ࡶ᭷ຠ࡛࠶ࡿࡇ࡜ࢆሗ࿌ࡋࡓࠋ
௒ᅇࡣࠊHA/Col ࢆࣛࢵࢺ㢌⵹㦵Ḟᦆ㒊࡟⛣᳜ࡍࡿࡇ࡜࡛ࠊேᕤ㦵ࢆ㊊ሙ࡜ࡋ࡚㦵᪂⏕ࡀ⏕
ࡌࡿࡇ࡜ࡀ☜ㄆ࡛ࡁࡓ࡜ྠ᫬࡟ࠊ◚㦵⣽⬊ࡀேᕤ㦵⾲㠃࡟ᏑᅾࡋࠊHA ࢆ㊊ሙ࡜ࡋ࡚◚㦵⣽
⬊ࡀศ໬ㄏᑟࡉࢀ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊ㦵⭷࡛⿕そࡋࡓ᳨య࡟࠾࠸࡚ࠊRANKL
㝧ᛶ⣽⬊࡜◚㦵⣽⬊ࡀከࡃⓎ⌧ࡋ࡚࠾ࡾࠊ㦵⭷࠿ࡽ RANKL ศἪಁ㐍స⏝ࡀാ࠸࡚࠸ࡿྍ
⬟ᛶࡀ♧၀ࡉࢀࡓࠋ
⫼ᬒ࠾ࡼࡧ┠ⓗ
ཱྀ⵹⿣࡟ᑐࡍࡿ἞⒪࡜ࡋ࡚㢡⿣㒊࡬ࡢ⛣᳜㦵࡟ࡣ⭠㦵࡞࡝⮬ᐙ㦵⤌⧊ࢆ⏝࠸ࡿࡢࡀ୍⯡
ⓗ࡛࠶ࡿࡀࠊ༑ศ࡞᥇㦵㔞ࡀ☜ಖ࡛ࡁ࡞࠸࡞࡝ࡢၥ㢟ࡶ࠶ࡿࠋࡑࡢ㝿ࠊࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃ
ࢱ࢖ࢺ㸦HA㸧ࡸșᆺࣜࣥ㓟୕࢝ࣝࢩ࣒࢘㸦ș-TCP㸧࡟௦⾲ࡉࢀࡿࢭ࣑ࣛࢵࢡࢫேᕤ㦵ࡢ㑅
ᢥࡶ࠶ࡿࡀࠊHA ࡣ㠀྾཰ᛶᮦᩱ࡛࠶ࡿࡓࡵࠊ㢡⿣ᙧᡂᚋࡢṑ⛉▹ṇ᫬ࡢၥ㢟ࡸேᕤ≀ࡀṧ
Ꮡࡍࡿࡇ࡜࡛⾡ᚋឤᰁ࡞࡝ࡢࣜࢫࢡࡀṧࡿࠋࡲࡓࠊș-TCP ࡣ྾཰ᛶᮦᩱ࡛࠶ࡿࡀ༑ศ࡞㦵
⤌⧊࡟そࢃࢀࡓ≧ែ࡛࡞࠸࡜ᮦᩱࡢࡳࡢ྾཰ࡀ㉳ࡇࡿ࡜࠸ࡗࡓၥ㢟ࡶ࠶ࡿࠋ
୍᪉ࠊḟୡ௦ேᕤ㦵࡜ࡋ࡚ࠊ⏕య㦵࡟㏆࠸⤌ᡂࢆᣢࡗࡓࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃࢱ࢖ࢺ㸭ࢥࣛ
࣮ࢤࣥ」ྜయ㸦௨ୗ HA/Col㸧ࡀᐇ⏝໬ࡉࢀࡓࠋHA/Col ࡣ྾཰ᛶࢆ♧ࡋࠊࢫ࣏ࣥࢪ≧ࡢ≀
ᛶࢆ᭷ࡍࡿࡓࡵࠊ⾑ᾮࡸ㦵㧊ᾮ࡞࡝ࢆྵᾐࡉࡏࡸࡍ࠸࡜࠸࠺ᛶ㉁ࡶ࠶ࡾࠊ⮫ᗋ἞㦂ࡢ⤖ᯝ
࡛ࡣᚑ᮶ࡢșTCP ேᕤ㦵࡟ẚ࡭ࠊඃࢀࡓ㦵ᙧᡂ⬟ࢆ᭷ࡍࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋࡋ࠿ࡋࠊ
㢌⵹㢡㢦㠃㡿ᇦ࡛ࡢ᭷ຠ࡞౑࠸᪉ࠊ⭷ᛶ㦵ࡢ㦵ᙧᡂࡢ࣓࢝ࢽࢬ࣒࡟㛵ࡋ࡚ࡣࡲࡔ▱ࡽࢀ࡚
࠸࡞࠸ࠋ ࡑࡇ࡛ࠊᮏ◊✲࡛ࡣࣛࢵࢺ㢌㡬㦵࡟ HA/Col ேᕤ㦵ࢆ⛣᳜ࡋࠊ㦵⭷ࡢ᭷↓࡟ࡼࡿ
ᕪ␗ࢆ⤌⧊Ꮫⓗ࡟᳨ウࡋࠊ᭷ຠᛶࢆ♧ࡍࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
1㸧
ᐇ㦂ື≀
࢜ࢫ Slc:SD ࣛࢵࢺ 㸺ධⲴ᫬㸼య㔜 200g 11 ༉
― 68 ―
2㸧
ᇙ᳜ᮦᩱ࠾ࡼࡧࢧ࢖ࢬ
HA/Col ேᕤ㦵㸦Ț⥺⁛⳦῭ࡳ㸧ȭ4™1~2mm
3㸧
⛣᳜㦵
㢌㡬㦵ᕥྑ࡟ࢺࣞࣃࣥࢆ⏝࠸࡚ȭ4mm ࡢ㦵඲ᒙḞᦆ๰ࢆసᡂࡋࠊୗグࡢ⩌ᵓᡂ࡛⛣᳜㦵ࢆ
ᇙ᳜ࡍࡿࠋ
࣭Ḟᦆ⩌㸸 HAP/Col ⿵ሸ࡞ࡋࠊ㦵⭷⿕そ↓ࡋ
࣭Ḟᦆ⩌㸸 HAP/Col ⿵ሸ࡞ࡋࠊ㦵⭷⿕そ᭷ࡾ
࣭HAP/Col ⿵ሸ⩌ࠊ㦵⭷⿕そ↓ࡋ
࣭HAP/Col ⿵ሸ⩌ࠊ㦵⭷⿕そ᭷ࡾ
࣭HAP/Col ⿵ሸ+PRP ⩌ࠊ㦵⭷⿕そ᭷ࡾ
4㸧 ๰ฎ⌮࡜ホ౯
㦵⭷࡜⓶⭵ࢆ⦭ྜ㛢๰ࡋࠊ๰㒊࡟ᑐࡋ࡚㌾⭯ࡢእ⏝࣭࣮࢞ࢮ⿕そ࡞࡝ࡢࢻࣞࢵࢩࣥࢢࡣ⾜
ࢃࡎ 4ࠊ8 㐌┠࡟᳨యࢆᅇ཰ࡋࠊ⤌⧊Ꮫⓗ᳨ウ㸦࣐࣍ࣝࣜࣥᅛᐃᚋࠊ⬺⅊ᶆᮏ㹆㹃ᰁⰍࠊච
␿ᰁⰍ㸧࡞ࡽࡧ࡟࣐࢖ࢡࣟ㹁㹒࡟ࡼࡿホ౯ࢆ⾜ࡗࡓࠋ
⤖ᯝ
㦵⭷Ꮡᅾୗࡢ⬺⅊ᶆᮏ㹆㹃ᰁⰍ㸸㸲㐌┠࡛ࡣᇙ᳜≀ࡀࡲࡔࡽ≧࡟Ꮡᅾࡋࠊ⥺⥔ᛶ⤖ྜ⤌⧊
ࡢቑ⏕࡜␗≀ᕧ⣽⬊ࢆㄆࡵࡓࠋ 㐌㛫࡛ࡣḞᦆ㒊ࡣᮍࡔ㦵࡛ࡣ⿕そࡉࢀ㑰ෆࡀࠊᚎࠎ࡟㦵᪂
⏕ࡀ㐍ࢇ࡛࠸ࡿ≧ែ࡛࠶ࡗࡓࠋ
࢜ࢫࢸ࢜࢝ࣝࢩࣥᰁⰍ㸸◚㦵⣽⬊ࡢ࣐࣮࣮࢝࡜ࡋ࡚࢝ࢸࣉࢩࣥ .㦵ⱆ⣽⬊ࡢ࣐࣮࣮࢝࡜ࡋ
࡚࢜ࢫࢸ࢜࢝ࣝࢩࣥ࡟ࡼࡿච␿ᰁⰍࡢ⤖ᯝ࡛ࡣࠊ㦵Ḟᦆ⩌࡛ࡣ࡯࡜ࢇ࡝㝧ᛶ⣽⬊ࢆㄆࡵࡎࠊ
ࢃࡎ࠿࡟㦵Ḟᦆ㒊᩿➃࡟࢜ࢫࢸ࢜࢝ࣝࢩࣥ㝧ᛶ⣽⬊ࢆㄆࡵࡓࠋ୍᪉ࡢ +$3&RO ⿵ሸ⩌࡟࠾
࠸࡚ࡣ࢝ࢸࣉࢩࣥ . 㝧ᛶ⣽⬊ࡀ☜ㄆ࡛ࡁࠊ⯆࿡῝࠸ࡇ࡜࡟ࡑࢀ࡜ࡣᑐഃࡢ㒊ศ࡟࢜ࢫࢸ࢜
࢝ࣝࢩࣥ㝧ᛶ⣽⬊ࢆㄆࡵࡓࠋ
࣐࢖ࢡࣟ㹁㹒㸸㦵Ḟᦆ⩌࡛ࡣ㦵ᱱࢆࡲࡗࡓࡃㄆࡵ࡞࠿ࡗࡓࠋ+$3&RO ⿵ሸ༢⊂⩌࡛ࡣࠊ⛣᳜
ࡋࡓ㹆㸿ࡢᵓ㐀ࡀࠊ㸶㹕࡟ῶᑡࡋ࡚࠸ࡿഴྥࢆㄆࡵࡓࡀࠊ㸯㸰㹕࡟ࡣ᪂⏕㦵࡟⨨᥮ࡉࢀ࡚
ࡁ࡚࠸ࡿ⌧㇟ࢆㄆࡵࡓࠋ
⪃ᐹ
㦵ࣜࣔࢹࣜࣥࢢ࡜ࡣࠊ㦵ࢆቯࡍാࡁࢆࡍࡿࠕ◚㦵⣽⬊ࠖࡀ㦵ࢆ྾཰㸦㦵྾཰㸧ࡍࡿ୍᪉࡛ࠊ
㦵ࢆసࡿാࡁࢆࡍࡿࠕ㦵ⱆ⣽⬊ࠖࡀࠊ◚㦵⣽⬊࡟ࡼࡗ࡚྾཰ࡉࢀࡓ㒊ศ࡟᪂ࡋ࠸㦵ࢆసࡿ
㸦㦵ᙧᡂ㸧ࡇ࡜࡛࠶ࡿࠋࡇࡢࣜࣔࢹࣜࣥࢢࡀ⤯࠼ࡎ⥆ࡅࡽࢀࡿࡇ࡜࡛ࠊ ᖺ㛫࡟ 㹼㸣
ࡢ㦵ࡀ᪂ࡋ࠸㦵࡟ධࢀ᭰ࢃࡗ࡚࠸ࡿࠋ+$3&RO ࡢ⮬ᐙ㦵⨨᥮࡟࠾࠸࡚ࡶࡇࡢ㦵ࣜࣔࢹࣜࣥࢢ
― 69 ―
ࡀ⏕ࡌ࡚࠸ࡿࡇ࡜ࡣᐜ᫆࡟᥎ ࡛ࡁࡿࠋࡑࡋ࡚ࠊࡇࡢࣂࣛࣥࢫࡀᔂࢀࠊ◚㦵⣽⬊࡟ࡼࡿ྾
཰ࡀಁ㐍ࡋࡓ≧ែࡀ㦵⢒ࡋࡻ࠺⑕ࡸ㛵⠇࣐ࣜ࢘ࢳ࡛࠶ࡿࠋ୍᪉◚㦵⣽⬊ࡀാࡃ࡞ࡗࡓࡶࡢ
ࡀ኱⌮▼⑓࡜࡞ࡿࡼ࠺࡟ࡇࢀࡽࡢࣂࣛࣥࢫࡣ㔜せ࡛࠶ࡿ࡜ࡉࢀ࡚࠸ࡿࠋ
௒ᅇࡣࠊ◚㦵⣽⬊ࡀேᕤ㦵⾲㠃࡟Ꮡᅾࡋࠊ+$ ࢆ㊊ሙ࡜ࡋ࡚◚㦵⣽⬊ࡀศ໬ㄏᑟࡉࢀ࡚࠸ࡿ
ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ◚㦵⣽⬊ࡢศ໬ㄏᑟࡢഐࡽ࡛ࠊ㦵ⱆ⣽⬊ࡣᏑᅾࡏࡎࠊ୧⪅ࡢ㛵㐃ࡢ㏣
ồࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓࠋࡲࡓࠊ㦵⭷࡛⿕そࡋࡓ᳨య࡟࠾࠸࡚ࠊ5$1./ 㝧ᛶ⣽⬊࡜◚㦵
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ࡢ⾲⣬࡟⥆ࡁࠊᮏᖺᗘࡣ J Neurosci.࡟᥇ᢥࡉࢀ࡚࠸ࡿࠋ
67 ࡢᑠᯘ⌮㤶ඛ⏕ࡣゅ⏣࡜ඹ࡟ࠊཱྀ⵹⿣ࠊ㌾ཱྀ⵹㯞⑷࡟ࡼࡿ㰯ဗ⭍㛢㙐୙඲ࡢ
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Ann Allergy Asthma Immunol.࡟Ⓨ⾲ࡋࡓࠋ
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ᖺᮎ࡛ ౛࡜ணᐃ㏻ࡾ㐍⾜ࡋ࡚࠸ࡿࠋ᮶ᖺᗘ࠿ࡽࡣᰣᮌ་⒪ࢭࣥࢱ࣮ࡶ
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ࡋ࡚ࡢ㡢ኌ㞀ᐖᑐ⟇ࡀ㛤࠿ࢀࡿ࡜ண᝿ࡉࢀࡿࠋ
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ኚ␗యࡢᙳ㡪ࠊኚ␗యࢆⓎ⌧ࡍࡿ㑇ఏᏊᨵኚ࣐࢘ࢫࢆ⏝࠸ࡓື≀ᐇ㦂ࢆ⾜ࡗ࡚࠸ࡿࠋᾏእ
࠿ࡽࡢ◊✲⏕ࡸ◊✲ဨࡶᅾ⡠ࡍࡿࡼ࠺࡟࡞ࡾࠊ◊✲ሗ࿌఍ࡸ௒ᖺᗘࡣ᪥ᮏ་⒪◊✲㛤Ⓨᶵ
ᵓ㸦AMED㸧ࡢ◊✲஦ᴗ࡬࡜⛣⾜ࡋࠊデ᩿ࡸ἞⒪࡟ྥࡅࡓ◊✲యไࡀࡼࡾồࡵࡽࢀࡿࡼ࠺
࡟࡞ࡗࡓࠋ
㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ඲࢚ࢡࢯ࣮࣒ゎᯒ
ᖹᡂ㸰㸱ᖺᗘ࡟ཌ⏕ປാ┬ࡢ㞴⑓࣭ࡀࢇ➼ࡢ⑌ᝈศ㔝ࡢᐇ⏝໬◊✲஦ᴗ࡜ࡋ࡚Ⓨ㊊ࡋࡓ
ḟୡ௦ DNA ࢩ࣮ࢡ࢚ࣥࢧ࣮ࢆ⏝࠸ࡓ㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ⥙⨶ⓗ㑇ఏᏊゎᯒࡣ㸲ᖺࡢᮇ
㛫ࢆ⤒࡚ࠊAMED ࡢ◊✲஦ᴗ࡜ࡋ࡚⥅⥆ࡉࢀࠊ㸰㸴ࡢ║⛉ᩍᐊࡸ║⛉㛵㐃᪋タࡀཧຍࡍࡿ
ࢥࣥࢯ࣮ࢩ࢔࣒࡬࡜ᡂ㛗ࡋࠊ࣮࢜ࣝࢪࣕࣃࣥయไ࡛㸱㸴⑌ᝈࡢ⑕౛᝟ሗ཰㞟࡜⾑ᾮ࣭ၚᾮ
ࡢ཰㞟ࢆ⾜ࡗ࡚࠸ࡿࠋᑐ㇟࡜࡞ࡿ⑌ᝈࡣᴟࡵ࡚⛥࡞ࡇ࡜࠿ࡽࠊ඲ᅜⓗ࡞ඹྠయไ࡟ࡼࡗ࡚
⑕౛ᩘࢆ☜ಖࡋࠊᅜ㝿ⓗ࡞➇தຊࡶቑࡋ࡚ࡁࡓࠋ
ᮏᖺᗘࡣデ᩿యไࢆぢ┤ࡋࠊ࢜ࣥࣛ࢖ࣥ⑕౛᝟ሗࢩࢫࢸ࣒ࢆⱥㄒ໬ࡋ࡚ࠊ඲࢚ࢡࢯ࣮࣒
ゎᯒࢆ◊✲㒊ෆ࡛⾜࠼ࡿయไࢆᵓ⠏ࡋࡓࠋࢤࣀ࣒ࡢ㸯㸣ࢆ༨ࡵࡿ㑇ఏᏊ࢚ࢡࢯࣥࢆ㸷㸷㸣
௨ୖࡢ཰⋡࡛࢟ࣕࣉࢳ࣮ࣕࡋࠊࡇࢀࢆᖹᆒ㸯㸮㸮ᅇ௨ୖ཯᚟ࡋ࡚ࢩ࣮ࢡ࢚ࣥࢫࡍࡿ࢚ࢡࢯ
࣮࣒ࢩ࣮ࢡ࢚ࣥࢫἲࡀ⏝࠸ࡽࢀ࡚࠸ࡿࠋࡇࡢ᪉ἲ࡟ࡼࡗ࡚ࡇࢀࡲ࡛ᅔ㞴࡛࠶ࡗࡓᐙ⣔༢఩
ࡢཎᅉ㑇ఏᏊ᥈⣴ࡀྍ⬟࡜࡞ࡾࠊࡇࡢ㸲ᖺ㛫࡛཰㞟ࡋࡓ඲᳨య㸦⣙㸯㸪㸰㸮㸮DNA ᳨
య㸧ࡢ඲࢚ࢡࢯ࣮࣒ࢩ࣮ࢡ࢚ࣥࢫࡀ⾜ࢃࢀࡓࠋࡑࡢ⤖ᯝࠊ᪂つ㑇ఏᏊኚ␗㸦᪤▱㑇ఏᏊ㸧
ࡸ᪂つ㑇ఏᏊࡀከᩘⓎぢࡉࢀࡓࠋ௒ᖺᗘࡣຎᛶ㑇ఏᏊᙧᘧࡢ㯤ᩬࢪࢫࢺࣟࣇ࢕࣮ࠊ࣮ࣞ࣋
ࣝ㯮ෆ㞀ࠊ⥙⭷Ⰽ⣲ኚᛶࠊ㗹య࣭ᮞయࢪࢫࢺࣟࣇ࢕࣮ࠊඛኳᛶኪ┣ࠊ඲Ⰽ┣࡞࡝ࢆ୰ᚰ࡟
ゎᯒࡋࠊ᫂ࡽ࠿࡟ࡉࢀࡓ୍㒊ࡢཎᅉ㑇ఏᏊኚ␗࡟ࡘ࠸࡚ࡣኚ␗యࡢᶵ⬟ゎᯒࡸࢱࣥࣃࢡ㉁
ᵓ㐀ゎᯒࠊࣀࢵࢡ࢖࣐ࣥ࢘ࢫࡀస〇ࡉࢀࡓࠋᖹᡂ㸰㸶ᖺᗘ࡟බ㛤ணᐃࡢ㑇ఏᏊኚ␗࡜⑓ែ
ࡢබ㛤⏝ࢹ࣮ࢱ࣮࣋ࢫࡶ‽ഛ୰࡛࠶ࡿࠋⓎぢࡉࢀࡓ㑇ఏᏊኚ␗ࡣデ᩿࢟ࢵࢺ࡜ࡋ࡚ၟရ໬
ࡀィ⏬ࡉࢀ࡚࠾ࡾࠊᖹᡂ㸰㸶ᖺᗘࡢ㛤ጞࢆࡵࡊࡋ࡚࠸ࡿࠋ
ᖹᡂ㸰㸴ᖺᗘ࡟ᮾி་⒪ࢭࣥࢱ࣮࡜ National Eye Institute, NIH ࡜ࡢඹྠ◊✲ዎ⣙ࢆ
⤖ࡧࠊAsian Eye Genetics Consortium (AEGC)ࢆ❧ࡕୖࡆࡓࡀࠊ࢔ࢪ࢔ྛᅜࡢ║⛉Ꮫ఍
࡛ࡇࡢάືࢆ⤂௓ࡋࡓ࡜ࡇࢁࠊ኱ࡁ࡞㈶ྠࢆᚓ࡚ࠊ࢔ࢪ࢔඲ᇦࡢ୺࡞║⛉᪋タ࡜ඹྠ◊✲
ࡀጞࡲࡗ࡚࠸ࡿࠋ
― 87 ―
ຍ㱋㯤ᩬኚᛶࡢⓎ⑕ᶵᗎ࡜࢝ࢽࢡ࢖ࢨࣝࣔࢹࣝࡸ࣐࢘ࢫࣔࢹࣝࡢゎᯒ
ຍ㱋㯤ᩬኚᛶࡣ⡿ᅜ࡛ࡣ᭱ࡶኻ᫂⋡ࡢ㧗࠸║⑌ᝈ࡛࠶ࡾࠊ᪥ᮏ࡛ࡶ㧗㱋໬ࡀ㐍ࡴࡇ࡜࡟
ࡼࡗ࡚ᝈ⪅ᩘࡣቑຍഴྥ࡟࠶ࡿࠋ⥙⭷ࡢ࡯ࡰ୰ᚰ࡟఩⨨ࡍࡿ㯤ᩬࡣ୍㒊ࡢ㟋㛗㢮ࡸ㫽㢮࡛
Ⓨ㐩ࡋ࡚࠾ࡾࠊ㏻ᖖࡢᐇ㦂࡟⏝࠸ࡽࢀࡿ࣐࢘ࢫࡸࣛࢵࢺ࡟ࡣᏑᅾࡋ࡞࠸ࠋᡃࠎࡣ⏕ᚋࡲࡶ
࡞ࡃ㯤ᩬ࡛ࢻ࣮ࣝࢮࣥࡀほᐹࡉࢀࡿୡ⏺࡛၏୍ࡢ㟋㛗㢮ࣔࢹࣝ㸦Umeda et al, IOVS
2005, Umeda et al, FASEB J 2005㸧ࢆ◊✲ᮦᩱ࡟ࡋ࡚ࡁࡓࠋࡇࡢ࢝ࢽࢡ࢖ࢨࣝࡣ⑓ែึ
ᮇ࡟࠾ࡅࡿ⥙⭷ࡢ≧ែࢆㄪ࡭ࡿࡇ࡜࡟฼⏝ࡋ࡚࠸ࡿࡀࠊྠ᫬࡟ᅜෆእࡢ኱Ꮫࡸ〇⸆௻ᴗࡢ
᪂⸆ࡢ㛤Ⓨ࡟ࡶ฼⏝ࡉࢀ࡚࠸ࡿࠋࡇࢀࡲ࡛࡟㸴ࡘࡢ⸆ຠヨ㦂ࡀ⾜ࢃࢀࡓࠋࡲࡓᚎᨺ๣࡟ࡘ
࠸࡚ࡶྡྂᒇᕷ❧኱Ꮫࡸᮾ໭኱Ꮫ࡜ࡢඹྠ◊✲࡟ࡼࡗ࡚⑌ᝈ࢝ࢽࢡ࢖ࢨࣝ࡟ᑐࡋ࡚ヨ㦂ࡀ
ᐇ᪋ࡉࢀ࡚࠸ࡿࠋ
ຍ㱋㯤ᩬኚᛶࡣከᅉᏊ⑌ᝈ࡜⪃࠼ࡽࢀ࡚࠾ࡾࠊ㑇ఏᏊࡸ⎔ቃࡀ㛵୚ࡍࡿ࡜⪃࠼ࡽࢀ࡚࠸
ࡿࠋ≉࡟㑇ఏᏊゎᯒ࡟ࡘ࠸࡚ࡣᡃࠎࢆྵࡵࠊከᩘࡢㄽᩥࡀⓎ⾲ࡉࢀࠊ⣙㸱㸮✀㢮ࡢ㑇ఏᏊࡀ
ឤཷᛶ㑇ఏᏊ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠸ࡿࠋࡇࡢ୰࡛ࡶ᭱ࡶ┦㛵ࡢ㧗࠸㸦p ್ࠊ࢜ࢵࢬẚ㸧HTRA1
㑇ఏᏊࡣࢭࣜࣥࣉࣟࢸ࢔࣮ࢮࢆࢥ࣮ࢻࡍࡿࠋᝈ⪅࡛ࡣ HTRA1 ࡢⓎ⌧ࡀቑຍࡍࡿ࡜⪃࠼ࡽ
ࢀ࡚࠾ࡾࠊࡇࡢቑຍࡢཎᅉࡀࡇࢀࡲ࡛୙࡛᫂࠶ࡗࡓࠋᡃࠎࡣ HTRA1 ࡢ㌿෗㡿ᇦࢆ◊✲ࡋࠊ
኱ࡁ࡞ሷᇶ㓄ิࡢḞᦆࡀᏑᅾࡍࡿࡇ࡜ࠊࡉࡽ࡟ࡑࡢḞᦆ࡟ࡼࡗ࡚ᢚไᅉᏊࡀ⤖ྜ࡛ࡁ࡞࠸
ࡇ࡜࡟ࡼࡗ࡚㌿෗άᛶࡀୖ᪼ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ(Iejima et al., JBC 2014)ࠋ㓄ิࡢḞ
ᦆ㡿ᇦ࡟ࡣ᪂ࡓ࡟㌿෗ಁ㐍ᅉᏊࡀ⤖ྜࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟ࡋࠊࡇࢀࡽࢆ㉁㔞ศᯒィ࡟
ࡼࡗ࡚ྠᐃࡋࡓࠋ௒ᚋ HTRA1 ࡢᢚไࡀ㔜せ࡟࡞ࡗ࡚ࡃࡿ࡜⪃࠼࡚࠸ࡿࠋ
ࡉࡽ࡟ HTRA1 ࡢቑຍࡀຍ㱋㯤ᩬኚᛶ࡜㛵ಀࡍࡿ࠿᳨ドࡍࡿࡓࡵ࡟ࠊHTRA1 ࢆ㧗Ⓨ⌧
ࡍࡿ㑇ఏᏊᨵኚ࣐࢘ࢫࢆస〇ࡋࡓ⤖ᯝࠊࣄࢺ࡜ྠᵝ࡞⬦⤡⭷࠿ࡽ⥙⭷࡟ࡴࡅ࡚ࡢ⾑⟶᪂⏕
ࡀほᐹࡉࢀࡓ(Nakayama, et al., IOVS 2014)ࠋࡇࢀࡽࡢ࣐࢘ࢫࡣࡉࡽ࡟㸯ᖺ㛫㣫⫱ࡉࢀࠊ
୺ὶ↮࡟ࡼࡿႚ↮ᐇ㦂ࡀ⾜ࢃࢀࡓࠋຍ㱋࡜ႚ↮ࡣຍ㱋㯤ᩬኚᛶࡢࣜࢫࢡᅉᏊ࡜⪃࠼ࡽࢀ࡚
ࡁࡓࡀࠊ௒ᅇࡢᐇ㦂࡛ࡣ HTRA1 㑇ఏᏊᨵኚ࣐࢘ࢫ࡜ṇᖖ࣐࢘ࢫ࡜ࡢᕪࡣほᐹࡉࢀ࡞࠿ࡗ
ࡓࠋ᪥ᮏே࡟ከ࠸ⁱฟᆺຍ㱋㯤ᩬኚᛶࡢ⑓ែࢆ෌⌧ࡍࡿ࣐࢘ࢫࣔࢹࣝ࡜ࡋ࡚ࠊ௒ᚋከࡃࡢ
◊✲࡟฼⏝ࡉࢀࡿ࡜ண᝿ࡉࢀࡿࠋᖹᡂ㸰㸶ᖺᗘࡣࡇࡢ HTRA1 ࡢᢚไࢆヨࡳࡿࠋ
― 88 ―
ࠝศᏊ⣽⬊⏕≀Ꮫ◊✲㒊ࠞ
ⁱฟᆺຍ㱋㯤ᩬኚᛶឤཷᛶ㑇ఏᏊ $506+75$ ࡢゎᯒ
ᐙᓥ኱㍜ 㸪୰ᒣ┿ኸ 㸪㔝⏣ᚭ 㸪ᒾ⏣ᓅ 㸦ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊 ࠊᮾி་⒪ࢭࣥࢱ࣮║⛉ 㸧
せ ⣙
ⁱฟᆺຍ㱋㯤ᩬኚᛶ㸦ZHW$0'㸧ࡣࠊ࡜ࡾࢃࡅ᪥ᮏே࡟ከ࠸ࢱ࢖ࣉࡢ $0' ࡛ࠊຍ㱋࡜࡜ࡶ
࡟⥙⭷ࡢ㯤ᩬ㒊࡟⬦⤡⭷ഃ࠿ࡽ⾑⟶᪂⏕ࡀ⏕ࡌࠊ㯤ᩬࡢ⥙⭷⤌⧊ࢆയᐖࡍࡿࡇ࡜࡛ࠊ᭱⤊
ⓗ࡟ᴟᗘࡢどຊపୗࡸኻ᫂ࢆᣍࡃ⑌ᝈ࡜ࡋ࡚▱ࡽࢀ࡚࠸ࡿࠋZHW$0' ࡢࣜࢫࢡᅉᏊ࡜ࡋ࡚ࠊ
ႚ↮ࡸ㧗⬡⫫㣗࡞࡝ࡢ⏕ά⩦័ࡸ࠸ࡃࡘ࠿ࡢ⎔ቃせᅉࡀ▱ࡽࢀ࡚࠸ࡿࡀࠊ୍᪉࡛ࠊ࠸ࡃࡘ
࠿ࡢ㑇ఏᏊኚ␗ࡀࣜࢫࢡᅉᏊ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠸ࡿࠋඛ⾜◊✲࡟࠾࠸࡚ࠊࢤࣀ࣒࣡࢖ࢻ㛵
㐃ゎᯒ*HQRPHZLGHDVVRFLDWLRQVWXG\*:$6࡞࡝ࢆ⏝࠸ࡓゎᯒ࡟ࡼࡾࠊ≉࡟ࠊࣄࢺᰁⰍ
యࡢ T ࡟఩⨨ࡍࡿ $506+75$ 㡿ᇦࡢኚ␗ࡣ ZHW$0' ࡢ⑌ᝈ࡜ᙉࡃ┦㛵ࡋ࡚࠸ࡿࡇ࡜
ࡀሗ࿌ࡉࢀ࡚࠾ࡾ'Z:HQ$HWDO6FLHQFHࠊᡃࠎࡢࢢ࣮ࣝࣉ࡟࠾࠸࡚ࡶࠊ᪥
ᮏேࡢ ZHW$0' ᝈ⪅ࢆᑐ㇟࡜ࡋࡓゎᯒ࡟ࡼࡾࠊ$506+75$ 㡿ᇦࡢኚ␗ࡀᙉࡃ┦㛵ࡋ࡚࠸
ࡿࡇ࡜ࢆሗ࿌ࡋ࡚࠸ࡿ*RWR$$NDKRUL0HWDO-2%',ࠋࡋ࠿ࡋࠊ⌧ᅾࡲ
࡛࡟ࠊࡇࡢ㡿ᇦࡢ࡝ࡢኚ␗ࡀ࡝ࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛⑌ᝈࡢⓎ⑕࡟ᐤ୚ࡋ࡚࠸ࡿࡢ࠿࡜࠸
ࡗࡓࠊ⏕≀Ꮫⓗ࡞࣓࢝ࢽࢬ࣒ࡣ᫂ࡽ࠿࡟࡞ࡗ࡚࠸࡞࠸ࠋࡇࡢࡼ࠺࡞⫼ᬒ࠿ࡽࠊᮏ◊✲࡛ࡣࠊ
ࡇࡢ㡿ᇦࡢኚ␗ࡀ⑌ᝈ࡟ཬࡰࡍ࣓࢝ࢽࢬ࣒ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊZHW$0' ᝈ⪅ࡢྠពࡢࡶ
࡜࡟᥇ྲྀࡋࡓᝈ⪅⏤᮶ࡢ᳨యࢆ⏝࠸࡚ࠊ$0' ᝈ⪅࡟࠾ࡅࡿ $506+75$ 㡿ᇦࡢヲ⣽࡞ゎᯒ
ࢆ⾜ࡗࡓࠋ
ᝈ⪅⏤᮶ࡢ '1$ ࡢ T 㡿ᇦࡢヲ⣽࡞ࢩ࣮ࢡ࢚ࣥࢫࢆㄪ࡭ࡓ⤖ᯝࠊ$506 ࡢ➨ ࢚ࢡࢯ
ࣥୖὶ EDVH ࡢ఩⨨࡜ࠊ$506 ࡢ➨ ࢚ࢡࢯࣥ࡜ +75$ ୖὶࡢ࢖ࣥࢺࣟࣥ㡿ᇦ࡟ࡲࡓࡀ
ࡿ఩⨨࡟ $0' ᝈ⪅࡟᭷ព࡟┦㛵ࡍࡿ≉ᚩⓗ࡞ኚ␗ࡀྠᐃࡉࢀࡓࠋࡉࡽ࡟ࠊࡇࡢኚ␗ࡀ $506
࠾ࡼࡧ +75$ ࡢࣉ࣮ࣟࣔࢱ࣮㡿ᇦࢆྵࡴࡇ࡜࠿ࡽࠊࡇࡢኚ␗ࢆྵࡴ᩿∦ࢆࢡ࣮ࣟࢽࣥࢢࡋࠊ
ࡇࢀࡽࡢ᩿∦ࢆ⥙⭷⣽⬊ࡢ FHOOOLQH ࡛࠶ࡿ $53(㸪5*&㸪: ࡟ᑟධࡋࠊ/XFLIHUDVH
DVVD\ ࢆ⏝࠸࡚ࣉ࣮ࣟࣔࢱ࣮άᛶࢆㄪ࡭ࡓࠋࡑࡢ⤖ᯝࠊ$506 ࡢࣉ࣮ࣟࣔࢱ࣮࡟ࡘ࠸࡚ࡣࠊ
࠸ࡎࢀࡢ⣽⬊࡛ࡶάᛶࡣࡳࡽࢀ࡞࠿ࡗࡓࡀࠊኚ␗ࢆྵࡴ +75$ ࣉ࣮ࣟࣔࢱ࣮᩿∦ࢆᑟධࡋ
ࡓ⩌࡛ࡣࠊ⥙⭷ࡢ⚄⤒⣔ࡢ⣽⬊ᰴ࡛࠶ࡿ 5*&: ࡟࠾࠸࡚ṇᖖᆺ࡜ẚ㍑ࡋ࡚ࣉ࣮ࣟࣔ
ࢱ࣮άᛶࡀୖ᪼ࡍࡿ⤖ᯝ࡜࡞ࡗࡓ,HMLPD'HWDO-%&ࠋ୍᪉࡛ࠊ⥙⭷Ⰽ⣲ୖ
⓶⣽⬊ᰴ࡛࠶ࡿ $53( ࡟ +75$ ࣉ࣮ࣟࣔࢱ࣮ࢆᑟධࡋࡓ⩌࡛ࡣࠊ+75$ ࣉ࣮ࣟࣔࢱ࣮άᛶ
ࡑࡢࡶࡢࡣࡳࡽࢀࡓࡀࠊṇᖖᆺ࡜ࡢ㛫࡟᭷ព࡞ᕪࡣࡳࡽࢀ࡞࠿ࡗࡓࠋࡲࡓࠊ&$* ࣉ࣮ࣟࣔ
ࢱ࣮࡛࣐࢘ࢫ +WU$ ࢆᙉไⓎ⌧ࡉࡏࡿࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࢆస〇ࡋࠊ+WU$ ࡢⓎ⌧
ୖ᪼ࡀ⥙⭷࡟ཬࡰࡍᙳ㡪ࢆㄪ࡭ࡓ⤖ᯝࠊ+WU$ ࢆᙉไⓎ⌧ࡉࡏࡓ࣐࢘ࢫ࡟࠾࠸࡚ࠊ⣙ 㸣
ࡢಶయ࡟࠾࠸࡚ࠊ⥙⭷࡟᪂⏕⾑⟶ࡀほᐹࡉࢀࡓ1DND\DPD0,HMLPD'HWDO,296
ࠋ
௨ୖࡢᐇ㦂⤖ᯝࡼࡾࠊ࣐࢘ࢫࣔࢹࣝ࡟࠾࠸࡚ +WU$ ࡢⓎ⌧ୖ᪼ࡀ⥙⭷࡟࠾ࡅࡿ⾑⟶᪂⏕
ࢆㄏⓎࡍࡿࣜࢫࢡ࡜࡞ࡿࡇ࡜ࡀ♧၀ࡉࢀࠊ$0' ᝈ⪅ࡢከࡃ࡟ࡳࡽࢀࡿ +75$ 㑇ఏᏊୖὶࡢ
― 89 ―
ኚ␗ࡀࠊୗὶ࡟࠶ࡿ +75$ ࡢⓎ⌧ୖ᪼ࢆಁࡍࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
┠ ⓗ
ຍ㱋㯤ᩬኚᛶ$0'ࡣࠊග⥺᭚㟢࡞࡝ࡢ⎔ቃⓗせᅉࠊႚ↮ࡸ㧗⬡⫫㣗࡞࡝ࡢ⩦័ⓗせᅉࠊ
࠸ࡃࡘ࠿ࡢឤཷᛶ㑇ఏᏊࡢኚ␗࡟ࡼࡿ㑇ఏⓗせᅉ࡟ࡼࡾ⏕ࡌࡿከᅉᏊ⑌ᝈ࡛࠶ࡿࡇ࡜⪃࠼
ࡽࢀ࡚࠾ࡾࠊ≉࡟㑇ఏⓗせᅉ࡟㛵ࡋ࡚ࡣࡇࢀࡲ࡛࡟࠸ࡃࡘ࠿ࡢឤཷᛶ㑇ఏᏊࡀⓎぢࡉࢀሗ
࿌ࡉࢀ࡚࠸ࡿ㸦.ODYHU&&HWDO㸦㸧$UFK2SKWKDOPRO̽.OHLQ%(
HWDO㸦㸧$P-(SLGHPLRO̽0H\HUV60HWDO㸦㸧$P-
2SKWKDOPRO̽㸪+DPPRQG&-HWDO㸦㸧2SKWKDOPRORJ\̽㸧
㏆ᖺࠊ࢔࣓ࣜ࢝ேࡢ $0' ᝈ⪅ࢆᑐ㇟࡜ࡋࡓࢤࣀ࣒࣡࢖ࢻ㛵㐃ゎᯒ*:$6࡟ࡼࡗ࡚ ␒ᰁ
Ⰽయ࡟Ꮡᅾࡍࡿ⿵య + ᅉᏊ&)+ࡢ㑇ఏᏊከᆺࠊ≉࡟ࠊ+ ᅉᏊࡢ <+ ࡢ㑇ఏᏊᆺ
UVࡀࠊࡇࡢ⑌ᝈ࡜ᙉࡃ┦㛵ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀ.OHLQ5-HWDO
6FLHQFH+DJHPDQ*6HWDO31$6ࠊࡇࢀࡲ࡛
ࡢ◊✲࡟ࡼࡾࠊ<+ ࡣḢ⡿ே࡞࡝ࡢⓑே࡛ࡣࠊ⑌ᝈ࡜ᙉࡃ┦㛵ࡋ࡚࠸ࡿࡶࡢࡢࠊ᪥ᮏே
ࡸ୰ᅜே࡞࡝ࡢ࢔ࢪ࢔ே࡛ࡣࠊ<+ ࡢ┦㛵ࡣほᐹࡉࢀ࡚࠸࡞࠸ࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ
2NDPRWR+HWDO0RO9LV*RWRK1HWDO+XP*HQHW
ࠋ
୍᪉࡛ࠊ᭱㏆ࠊᰁⰍయ ␒࡟࠾ࡅࡿࠊ/2&$506DJHUHODWHGPDFXORSDWK\
VXVFHSWLELOLW\࡜ +75$+75$VHULQHSHSWLGDVH㑇ఏᏊ㡿ᇦࡢ㑇ఏᏊከᙧࡀࠊZHW$0'
ᝈ⪅࡜ᙉࡃ┦㛵ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣࠊࡇࢀࡲ࡛࡟ࠊ᪥ᮏேࡢ ZHW$0' ᝈ⪅
ࢆᑐ㇟࡜ࡋࡓ *:$6 ࡟࡚ゎᯒࢆ⾜ࡗࡓ⤖ᯝࠊḢ⡿ே࡛ᙉࡃ┦㛵ࡋࡓ⿵య + ᅉᏊࡢ㑇ఏᏊከᆺ
ࡣ┦㛵ࡏࡎࠊ$506+75$ ࡢ㑇ఏᏊ㡿ᇦࡢ㑇ఏᏊከᆺࡀᙉࡃ┦㛵ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ
*RWR$$NDKRUL0HWDO-2%',ࠋࡇࢀࡲ࡛ࡢゎᯒ࡟ࡼࡾࠊ*:$6 ࡟ࡼࡗ࡚ࠊ
ZHW$0' ࡟࠾࠸࡚ᰁⰍయ ␒ࡢ T 㡿ᇦ࡟ᙉ࠸┦㛵ࡀほᐹࡉࢀ࡚࠾ࡾࠊࡇࡢ㡿ᇦࡢࢱࢢ
613 ࡛࠶ࡿ UV ࡀᙉࡃ┦㛵ࡍࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋ௨ୖࡼࡾࠊUV ࡜㐃㙐
୙ᖹ⾮ࢆඹ᭷ࡍࡿ㡿ᇦࡣࠊ$506 ࡜ +75$ ࡢ 㑇ఏᏊ࡟ࡲࡓࡀࡗ࡚࠸ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ
ࡀࠊ⌧ᅾࡢ࡜ࡇࢁࠊࡇࡢ㡿ᇦࡀ࡝ࡢࡼ࠺࡟⑌ᝈࡢⓎ⑕࡜㛵ࢃࡗ࡚࠸ࡿ࠿ࡣศ࠿ࡗ࡚࠸࡞࠸ࠋ
ࡇࡢࡼ࠺࡞⫼ᬒࢆ㋃ࡲ࠼ࠊᮏ◊✲ࡣࠊࡇࡢ㡿ᇦ࡟࠾ࡅࡿ $0' ᝈ⪅࡟᭷ព࡞ኚ␗ࢆㄪ࡭ࠊࡑ
ࢀࡽࡢኚ␗ࡀ࡝ࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛ $0' ࡢⓎ⑕࡟ᐤ୚ࡍࡿ࠿ࢆヲ⣽࡟ࡋࡽ࡭ࡿࡇ࡜ࢆ┠
ⓗ࡜ࡋ࡚ᐇ㦂ࢆ⾜ࡗࡓࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
࠙$0' ᝈ⪅≉␗ⓗ࡞ኚ␗ࡢ᳨ฟࠚ࢖ࣥࣇ࢛࣮࣒ࢻࢥࣥࢭࣥࢺ࡟ࡼࡾ◊✲㊃᪨ࢆ༑ศ࡟ㄝ
᫂ࡋ࡚ྠពࢆᚓࡓ ZHW$0' ᝈ⪅ ே࠾ࡼࡧࠊࢥࣥࢺ࣮ࣟࣝ⩌࡜ࡋ࡚ⓑෆ㞀ᝈ⪅ ேࡼ
ࡾ᥇⾑ࢆ⾜࠸ࠊࡑࢀࡒࢀࡢᝈ⪅᳨యࡼࡾࢤࣀ࣒ '1$ ࢆᢳฟࡋࡓࠋࡑࢀࡒࢀࡢᝈ⪅⏤᮶ࡢ '1$
࡟ᑐࡋ࡚ࠊඛ⾜◊✲࡟ࡼࡾ ZHW$0' ᝈ⪅≉␗ⓗ࡞ኚ␗ࡢᏑᅾࡀண᝿ࡉࢀࡿ ␒ᰁⰍయࡢ
$506 ࠾ࡼࡧ +75$ ࡢ㑇ఏᏊ࡟ࡲࡓࡀࡿ NES ࡢ㡿ᇦࡢࢩ࣮ࢡ࢚ࣥࢫࢆ⾜࠸ࠊࡇࡢ㡿ᇦ
࡟ྵࡲࢀࡿ 613V ࡸ LQVHUWLRQࠊGHOHWLRQ ࡟ࡘ࠸࡚ࠊ$0' ᝈ⪅⩌࡟┦㛵ࡢ㧗࠸ࡶࡢࢆ᳨ฟࡋ
ࡓࠋ
࠙$0' ឤཷᛶ㑇ఏᏊࡢࣉ࣮ࣟࣔࢱ࣮άᛶࡢ ᐃࠚࢩ࣮ࢡ࢚ࣥࢫࡢ⤖ᯝࢆ㋃ࡲ࠼࡚ࠊ$0'
― 90 ―
ᝈ⪅࡟≉ᚩⓗ࡞ኚ␗ࡀ᳨ฟࡉࢀࡓࠊ$506 㑇ఏᏊࡢ࢚ࢡࢯࣥ㸯ୖὶ ES ࡟ࡲࡓࡀࡿ㡿ᇦ
࡜ࠊ$506 ࡢ࢚ࢡࢯࣥ㸰ࡢ୍㒊ࢆྵࡴࠊ+75$ 㑇ఏᏊࡢ࢚ࢡࢯࣥ㸯ୖὶ⣙ NES ࡟ࡲࡓࡀ
ࡿ㡿ᇦࢆࢡ࣮ࣟࢽࣥࢢࡋࠊࣝࢩࣇ࢙࣮ࣛࢮ࢔ࢵࢭ࢖࡟ࡼࡗ࡚ࠊࣉ࣮ࣟࣔࢱ࣮άᛶࢆ ᐃࡋ
ࡓࠋ
࠙+WU$ ࡢⓎ⌧㒊఩ࡢゎᯒࠚ࣐࢘ࢫ⥙⭷⤌⧊ෆ࡟࠾ࡅࡿ +WU$ ࡢⓎ⌧ࣃࢱ࣮ࣥࢆㄪ࡭ࡿࡓ
ࡵࠊș࢞ࣛࢡࢺࢩࢲ࣮ࢮࢆ࣏࣮ࣞࢱ࣮㑇ఏᏊ࡜ࡋ࡚⤌ࡳ㎸ࢇࡔ +WU$ ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫ
ࡢ࣊ࢸࣟᆺࢆ⏝࠸࡚ࠊ࣐࢘ࢫ⥙⭷⤌⧊࡟࠾ࡅࡿ +WU$ ࡢⓎ⌧ࣃࢱ࣮ࣥࢆච␿ᰁⰍ࡟ࡼࡾ᳨
ฟ࣭ྠᐃࡋࡓࠋ
⤖ ᯝ
࠙$506+75$ ࡢࣉ࣮ࣟࣔࢱ࣮㡿ᇦࡢゎᯒࠚ ࢩ࣮ࢡ࢚ࣥࢫ࡟ࡼࡾຍ㱋㯤ᩬኚᛶᝈ⪅ࡢࢤ
ࣀ࣒㓄ิࢆㄪ࡭ࡓ⤖ᯝࠊ$506 ࡢ➨ ࢚ࢡࢯࣥ࠿ࡽ ES ୖὶࡢ఩⨨࡟ࠊ ࡘࡢ & ࡀ $ ࡟ࡍ
࡭࡚⨨ࡁ᥮ࢃࡾࠊ$ ࡀ ಶ㐃⥆ࡍࡿ ZHW$0' ᝈ⪅࡟┦㛵ᛶࡢ㧗࠸≉ᚩⓗ࡞㓄ิࡀ᳨ฟࡉࢀࠊ
ࡲࡓࠊ+75$ ࡢ➨ ࢚ࢡ
ࢯࣥࡼࡾ NES ୖὶࡢࠊ
$506 ➨ ࢚ࢡࢯࣥ࡟ࡲ
ࡓࡀࡿ఩⨨࡟ࠊSE ࡟
ࢃࡓࡗ࡚Ḟᦆࡸ⨨᥮ࡀ⏕
ࡌ࡚࠸ࡿ ZHW$0' ᝈ⪅ࡢ
ࢤࣀ࣒࡟┦㛵ᛶࡢ㧗࠸ኚ
␗㒊఩㸦LQGHO ኚ␗㸧ࢆ
☜ㄆࡋࡓ㸦ᅗ 㸧ࠋ
ࡉࡽ࡟ࠊࡇࡢኚ␗㒊఩
ࢆྵࡴᙧ࡛ $506 ࠾ࡼࡧ
+75$ ࡢࣉ࣮ࣟࣔࢱ࣮㡿
ᇦࢆࢡ࣮ࣟࢽࣥࢢࡋࠊ
ᅗ 㸸ARMS2-HTRA1 ࡢࢩ࣮ࢡ࢚ࣥࢫ⤖ᯝ
ࣄࢺ⥙⭷Ⰽ⣲ୖ⓶⣽⬊ࡢ
⣽⬊ᰴ࡛࠶ࡿ $53(ࠊࣛࢵࢺ⥙⭷⚄⤒⠇⣽⬊ࡢ⣽⬊ᰴ࡛࠶ࡿ 5*&ࠊ࣐࢘ࢫど⣽⬊⣽⬊ᰴ࡛
࠶ࡿ : ࢆ⏝࠸࡚ࣝࢩࣇ࢙࣮ࣛࢮ࢔ࢵࢭ࢖࡟ࡼࡾࣉ࣮ࣟࣔࢱ࣮άᛶࢆㄪ࡭ࡓ⤖ᯝࠊ$506
ୖὶࡢኚ␗ࢆྵࡴ㓄ิ࡟࠾࠸࡚ࡣࠊࡍ࡭࡚ࡢ⣽⬊ᰴ࡛࡯࡜ࢇ࡝ࣉ࣮ࣟࣔࢱ࣮άᛶࡣ࡞ࡃࠊ
ࢥࣥࢺ࣮ࣟࣝ⩌࡜ẚ㍑ࡋ࡚ࡶ᭷ព࡞ᕪࡣ࡞࠿ࡗࡓࠋ୍᪉ࠊ+75$ ୖὶࡢ LQGHO ኚ␗ࢆྵࡴ
㓄ิࡢࣉ࣮ࣟࣔࢱ࣮άᛶࢆㄪ࡭ࡓ⤖ᯝࠊ$53( ࡛ࡣ᭷ព࡞ᕪࡣࡳࡽࢀ࡞࠿ࡗࡓࡶࡢࡢࠊ
5*& ࡜ : ࡛ࡣࠊࢥࣥࢺ࣮ࣟࣝ⩌࡜ẚ㍑ࡋ࡚ࠊZHW$0' ᝈ⪅࡟ከࡃࡳࡽࢀࡿ LQGHO ᆺࡢ㓄
ิࢆࡶࡘࣉ࣮ࣟࣔࢱ࣮ࡢάᛶࡀ᭷ព
࡟㧗࠸⤖ᯝ࡜࡞ࡗࡓࠋࡇࢀ࡟ࡼࡾࠊ
LQGHO ᆺࡢ㓄ิࢆࡶࡘ࡛ࡣࠊ +75$
ࡢⓎ⌧ࡀ᭷ព࡟ୖ᪼ࡋ࡚࠸ࡿࡇ࡜ࡀ
♧၀ࡉࢀࡿ⤖ᯝ࡜࡞ࡗࡓ㸦ᅗ 㸧
ࠋ
ࡉࡽ࡟ࡣࠊෆᅾᛶࡢࣄࢺ +75$ ࡢ
― 91 ―
Ⓨ⌧ࢆㄪ࡭ࡿࡓࡵࠊ೺ᖖ⪅࠾ࡼࡧ $0' ᝈ⪅⏤᮶ࡢ L36 ⣽⬊ࢆస〇ࡋࠊ㑇ఏᏊᆺࡈ࡜ࡢ +75$
ࡢⓎ⌧ࢆㄪ࡭ࡓ⤖ᯝࠊ1RUPDOLQGHO࣊ࢸࣟᆺ࠾ࡼࡧ LQGHOLQGHO࣍ࣔᆺࡢ㑇ఏᏊᆺ
ࡢ L36 ⣽⬊࡟࠾࠸࡚ࠊ1RUPDO1RUPDOṇᖖᆺ࡟ẚ࡭࡚ +75$ ࡢ㧗࠸Ⓨ⌧ࡀぢࡽࢀࡓࠋ
ࡉࡽ࡟ࠊ$506 ࣉ࣮ࣟࣔࢱ࣮ࡢኚ␗㡿ᇦࡀࠊ+75$ ࣉ࣮ࣟࣔࢱ࣮࡟୚࠼ࡿᙳ㡪ࢆㄪ࡭ࡿࡓ
ࡵࠊኚ␗㡿ᇦࢆྵࡴ $516 ࣉ࣮ࣟࣔࢱ࣮᩿∦࡜ LQGHO ࢆྵࡴ +75$ ࣉ࣮ࣟࣔࢱ࣮᩿∦ࢆ㐃
ᅗ 㸸HTRA1 SURPRWHU ࡢάᛶ
⥆ࡋ࡚࣋ࢡࢱ࣮࡟ࢡ࣮ࣟࢽࣥࢢࡋࠊࣝࢩ
ࣇ࢙࣮ࣛࢮ࢔ࢵࢭ࢖ࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ
$506 ࣉ࣮ࣟࣔࢱ࣮ࡢ㓄ิࡢ᭷↓ࡸኚ␗
ࡢ㐪࠸࡛άᛶ್࡟ᕪࡣ࡞ࡃࠊ$506 ࣉࣟ
࣮ࣔࢱ࣮ࡢኚ␗ࡣࠊࡑࡢୗὶࡢ +75$ ࡢ
Ⓨ⌧࡟ࡣᙳ㡪ࢆཬࡰࡉ࡞࠸ࡇ࡜ࡀศ࠿ࡗ
ࡓࠋ
࠙+WU$ ࡢⓎ⌧㒊఩ࡢゎᯒࠚḟ࡟ࠊ๓㏙
ࡢ⤖ᯝࡼࡾࠊ$0' ᝈ⪅࡟࠾࠸࡚ +75$ ࡢ
ࣉ࣮ࣟࣔࢱ࣮άᛶࡢୖ᪼ࡀ⏕ࡌ࡚࠸ࡿྍ
⬟ᛶࡀ♧၀ࡉࢀࡓࡇ࡜࠿ࡽࠊș࢞ࣛࢡࢺ
ࢩࢲ࣮ࢮࢆ࣏࣮ࣞࢱ࣮㑇ఏᏊ࡜ࡋ࡚⤌ࡳ
㎸ࢇࡔ +WU$ ࣀࢵࢡ࢔࢘ࢺ࣐࢘ࢫࡢ࣊ࢸ
ᅗ 㸸ARMS2 ࣉ࣮ࣟࣔࢱ࣮㡿ᇦࡀ HTRA1
ࣟᆺࢆ⏝࠸࡚ࠊ⥙⭷࡟࠾ࡅࡿ +WU$ ࡢⓎ
࡟୚࠼ࡿᙳ㡪
⌧㒊఩ࡢ᳨ฟࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ+WU$
ࡢࣉ࣮ࣟࣔࢱ࣮άᛶࢆ♧ࡍș࢞ࣛࢡࢺ
ࢩࢲ࣮ࢮࡣ⥙⭷እ㢛⢏ᒙ࡟ከࡃⓎ⌧ࡋ࡚
࠾ࡾࠊ+WU$ ࡢࢱࣥࣃࢡ㉁ࡣど⣽⬊ࡢෆ
⠇࠾ࡼࡧእ⠇࡟ከࡃⓎ⌧ࡋ࡚࠸ࡓᅗ ࠋ
࠙ࣉ࣮ࣟࣔࢱ࣮⤖ྜศᏊࡢྠᐃࠚ๓㏙ࡢ
ᅗ 㸸࣐࢘ࢫ⥙⭷࡟࠾ࡅࡿ HtrA1 ࡢⓎ⌧
⤖ᯝࡼࡾࠊ+75$ ୖὶࡢ LQGHO ኚ␗ࡀ
+75$ ࡢⓎ⌧ㄪ⠇࡟ᐤ୚ࡋ࡚࠸ࡿࡇ࡜ࡀ
ண᝿ࡉࢀࡿࡇ࡜࠿ࡽࠊ/&0606 ࢆ⏝࠸࡚ࠊ
ࡇࡢ㡿ᇦ࡟⤖ྜࡍࡿศᏊࡢྠᐃࢆ⾜ࡗࡓࠋࣅ࢜ࢳࣥᶆ㆑ࡋࡓ LQGHO ࡜ྠࡌ㓄ิࡢ᩿∦ࢆ
'\QD%HDGV ࡟྾╔ࡉࡏࠊࡇࡢ '\QD%HDGV ࡜ : ⣽⬊ࡢࢱࣥࣃࢡ㉁ /\VDWH ࢆΰ࿴ࡋࠊ࣏ࣜ
࢔ࢡࣜࣝ࢔࣑ࢻ㟁ẼὋື࡟ࡼࡾࠊࡇࡢ LQGHO 㓄ิ࡟⤖ྜࡋࡓࢱࣥࣃࢡ㉁ࢆ༢㞳ࡋࠊ/&0606
࡛ྠᐃࡋࡓ⤖ᯝࠊ࠸ࡃࡘ࠿ࡢೃ⿵ศᏊࡀྠᐃࡉࢀࠊ≉࡟ࠊ1)ȡ% ࡸ +,) ࡢไᚚᅉᏊ࡛࠶
ࡿ /\ULF ࡀ㧗࠸ࢫࢥ࢔ࢆ♧ࡋࡓ㸦ᅗ 㸧ࠋ
― 92 ―
࠙+WU$ ࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࡢゎᯒࠚ&$*ࣉ࣮ࣟࣔࢱ࣮ࢆ⏝࠸࡚࣐࢘ࢫ +WU$ ࢆᙉ
ไⓎ⌧ࡉࡏࡿࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࢆస〇ࡋࠊࡇࡢ࣐࢘ࢫࡢ⥙⭷ࢆゎᯒࡋࡓ⤖ᯝࠊ⏕
ᚋ⣙ ᖺࡢ࣐࢘ࢫ࡟࠾࠸࡚ࠊ⣙ 㸣ࡢ☜❧࡛ $0' ࡟㢮ఝࡋࡓ⥙⭷ࡢ᪂⏕⾑⟶ࡀほᐹࡉࢀࠊ
+WU$ ࡀ⥙⭷࡟࠾࠸࡚⾑⟶᪂⏕ࢆㄏⓎࡉࡏࡿస⏝ࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓᅗ 㸧ࠋ
ᅗ 㸸LQGHO ኚ␗㡿ᇦ⤖ྜೃ⿵ศᏊ
ᅗ 㸸HtrA1 ࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࡢゎᯒ⤖ᯝ
ࡲ࡜ࡵ
ᮏ◊✲࡛ࡣ $0' ᝈ⪅࡜┦㛵ᛶࡢ㧗࠸ $506+75$ 㡿ᇦࡢኚ␗࡟╔┠ࡋࠊZHW$0' ᝈ⪅
⏤᮶ࡢ᳨యࢆ⏝࠸࡚ࠊ$0' ᝈ⪅࡟࠾ࡅࡿ $506+75$ ࡢࢩ࣮ࢡ࢚ࣥࢫࢆㄪ࡭ࡓ⤖ᯝࠊ$506
ࡢ➨ ࢚ࢡࢯࣥୖὶ࡜ࠊ$506 ࡢ➨ ࢚ࢡࢯࣥ࡜ +75$ ୖὶࡢ࢖ࣥࢺࣟࣥ࡟ࡲࡓࡀࡿ఩⨨
࡟ $0' ᝈ⪅࡟᭷ព࡟┦㛵ࡍࡿኚ␗ࡀྠᐃࡉࢀࡓࠋḟ࡟ࠊࡇࡢኚ␗ࡀ $506 ࠾ࡼࡧ +75$ ࡢ
ࣉ࣮ࣟࣔࢱ࣮㡿ᇦ࡟┦ᙜࡍࡿࡇ࡜࠿ࡽࠊࡇࡢኚ␗ࢆྵࡴ᩿∦ࢆࢡ࣮ࣟࢽࣥࢢࡋࠊࡇࢀࡽࡢ
᩿∦ࢆ⥙⭷⣽⬊ࡢ FHOOOLQH ࡛࠶ࡿ $53(㸪5*&㸪: ࡟ᑟධࡋࠊࣉ࣮ࣟࣔࢱ࣮άᛶࢆ
ㄪ࡭ࡓࠋࡑࡢ⤖ᯝࠊ$506 ࣉ࣮ࣟࣔࢱ࣮᩿∦࡟ࡘ࠸࡚ࡣࠊ࠸ࡎࢀࡢ⣽⬊࡛ࡶάᛶࡣࡳࡽࢀ
࡞࠿ࡗࡓࡀࠊ+75$ ࣉ࣮ࣟࣔࢱ࣮᩿∦ࢆᑟධࡋࡓ⩌࡛ࡣࠊ5*&: ࡟࠾࠸࡚ṇᖖᆺ࡜ẚ
㍑ࡋ࡚ኚ␗ᆺࡢࣉ࣮ࣟࣔࢱ࣮άᛶࡀୖ᪼ࡍࡿ⤖ᯝ࡜࡞ࡗࡓࠋࡉࡽ࡟ࠊ+WU$ ࢆᙉไⓎ⌧ࡉ
― 93 ―
ࡏࡿࢺࣛࣥࢫࢪ࢙ࢽࢵࢡ࣐࢘ࢫࢆస〇ࡋࠊࡇࡢ࣐࢘ࢫࡢ⥙⭷ࢆゎᯒࡋࡓ⤖ᯝࠊ$0' ࡟㢮ఝ
ࡋࡓ⥙⭷ࡢ᪂⏕⾑⟶ࡀほᐹࡉࢀࡓࠋ௨ୖࡢ⤖ᯝࡼࡾࠊ+75$ ୖὶ࡟ࣉ࣮ࣟࣔࢱ࣮άᛶࢆୖ
᪼ࡉࡏࡿኚ␗ࡀᝈ⪅࡟᭷ព࡟Ꮡᅾࡋ࡚࠾ࡾࠊࡇࡢάᛶୖ᪼ࡀ⑌ᝈࣜࢫࢡࢆୖ᪼ࡉࡏࡿ୍ᅉ
࡟࡞ࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋ
― 94 ―
ࠝศᏊ⣽⬊⏕≀Ꮫ◊✲㒊ࠞ
㑇ఏᛶ⥙⭷Ⰽ⣲ኚᛶᝈ⪅࡜㗹యᮞయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅ࡑࢀࡒࢀ࠿ࡽぢࡘ࠿ࡗࡓ &RUI
㑇ఏᏊࡢ᪂つኚ␗ࡢྠᐃ
㸯
㸰
㸱
ᒸᮏᬗᏊ ࠊ⁁⏣῟ ࠊຍ⸨ගᘯ ࠊᅧྜྷ୍ᶞ㸲ࠊྜྷṊ࿴ᩄ㸳ࠊ:LOOLDP&6XOWDQ㸯ࠊ
ᒣᓮṇᚿ㸴ࠊゅ⏣࿴⦾㸵ࠊᒾ⏣ᓅ㸯
㸦㸯ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊ࠊ㸰ᖇி኱Ꮫ་Ꮫ㒊║⛉Ꮫㅮᗙࠊ㸱᫛࿴኱Ꮫ་Ꮫ㒊ᑠඣ⛉Ꮫㅮ
ᗙࠊ㸲㏆␥኱Ꮫ་Ꮫ㒊║⛉Ꮫᩍᐊࠊ㸳᪥ᮏࢯࣇࢺ࢙࢘࢔࣐ࢿࢪ࣓ࣥࢺᰴᘧ఍♫ࠊ㸴⟃Ἴ኱
Ꮫ་Ꮫ㒊ᩚᙧእ⛉ࠊ㸵どぬ◊✲㒊ࠊ
㸧
せ ⣙
ᮏ◊✲ᐊ࡛ࡣ᪥ᮏேࡢ㑇ఏᛶ⥙⭷ኚᛶ⑌ࡢཎᅉ㑇ఏᏊࢆྠᐃࡍࡿ㑇ఏゎᯒࢆ⾜ࡗ࡚࠸ࡿࠋ
௒ᅇࠊ⥙⭷Ⰽ⣲ኚᛶᝈ⪅࡜㗹యᱰయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅ࢆྵࡴ ᐙ⣔ࡢ඲࢚ࢡࢯࣥ㓄ิゎ
ᯒ㸦:(6㸧࠿ࡽࠊཎᅉ㑇ఏᏊೃ⿵࡜ࡋ࡚ &RUI ࡀぢࡘ࠿ࡗࡓࠋ&RUI ࡣ⧄ẟ㑇ఏᏊ࡛࠶
ࡾࠊࡍ࡛࡟඲㌟ᛶ⑌ᝈ࡛࠶ࡿ࿧྾୙඲ᛶ⬚㒌␗ᙧᡂ⑕࡜㯤ᩬ㒊ࡢ␗ᖖࢆక࠺⥙⭷ኚᛶࡢཎ
ᅉ㑇ఏᏊ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠸ࡓࡀࠊ࢔ࢪ࢔ே࠿ࡽࡣึࡵ࡚ࠊࡲࡓ⥙⭷Ⰽ⣲ኚᛶᝈ⪅࠿ࡽࡣ
ึࡵ࡚ࡢሗ࿌࡛࠶ࡿࠋࡲࡓࠊ௚࡛ࡣሗ࿌ࡉࢀ࡚࠸࡞࠸࢔࣑ࣀ㓟఩⨨ࡢኚ␗ࡀ࠶ࡗࡓࠋ&RUI
ࢱࣥࣃࢡ㉁ࡣ⥙⭷ど⣽⬊ࡢእ⠇̺ෆ⠇࡟ᒁᅾࡋ࡚࠸ࡓࠋኚ␗ᆺࢱࣥࣃࢡ㉁ࡢⓎ⌧ゎᯒࡢ⤖
ᯝࠊᝈ⪅࠿ࡽぢࡘ࠿ࡗࡓ㑇ఏᏊኚ␗࡟ࡼࡗ࡚ࢱࣥࣃࢡ㉁㔞ࡀῶᑡࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
ࡇࢀࡽࡢ⤖ᯝ࠿ࡽࠊᝈ⪅࡛ࡣ &RUI ࢱࣥࣃࢡ㉁ࡢ㔞ࡀ୙㊊ࡍࡿࡓࡵ࡟ど⣽⬊ࡢእ⠇̺ෆ
⠇ࢆᨭ࠼ࡿ⧄ẟ㒊ศࡢᙧᡂ࣭⥔ᣢࡀ࡛ࡁࡎ࡟ど⣽⬊ࡀኚᛶࡋࠊ⥙⭷Ⰽ⣲ኚᛶཪࡣ㗹యᮞయ
ࢪࢫࢺࣟࣇ࢕࣮ࡢ⑕≧ࡀ⌧ࢀࡿ࡜⪃࠼ࡽࢀࡓࠋ
┠ ⓗ
ࣄࢺࡣእ㒊᝟ሗࡢ ๭௨ୖࢆどぬ࡟౫Ꮡࡋ࡚࠸ࡿ࡜ゝࢃࢀ࡚࠾ࡾࠊ⥙⭷ኚᛶ⑌ᝈ࡛ぢࡽࢀ
ࡿࡼ࠺࡞どຊࡢᣢ⥆ⓗపୗࡸኻ᫂ࡣ⏕άࡢ㉁࡟኱ࡁ࡞ᙳ㡪ࢆ୚࠼ࡿࠋ㑇ఏᛶ⥙⭷ኚᛶ⑌ᝈ
࡟ࡣ⌧ᅾᑐฎ⒪ἲࡋ࠿࡞ࡃࠊཎᅉ㑇ఏᏊࡢᶵ⬟ゎᯒࡀ᪂ࡋ࠸἞⒪᪉ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡀࡿ࡜
⪃࠼ࡽࢀ࡚࠸ࡿࡀࠊ᪤▱ࡢཎᅉ㑇ఏᏊ࡟ࡣኚ␗ࡀぢࡽࢀ࡞࠸ᝈ⪅ࡶከ࠸ࠋࡲࡓ㑇ఏᏊኚ␗
ࡢ㢖ᗘࡣே✀㛫࡛␗࡞ࡗ࡚࠾ࡾࠊ᪥ᮏேᝈ⪅ࡢཎᅉ㑇ఏᏊྠᐃࡣ᪥ᮏཬࡧ࢔ࢪ࢔࡛᭷ຠ࡞
἞⒪᪉ἲࡢ㛤Ⓨ࡟㔜せ࡞ᇶ┙᝟ሗ࡜࡞ࡿࠋᮏ◊✲ࡣࠊ᪥ᮏேᝈ⪅ࢆᑐ㇟࡜ࡋ࡚⾜ࢃࢀࡓ :(6
ࡢ⤖ᯝࢆࡶ࡜࡟ࠊ᪂つኚ␗ࡀぢࡘ࠿ࡗࡓ &RUI ࡟ࡘ࠸࡚ሗ࿌ࡍࡿࠋ
ᑐ㇟࠾ࡼࡧ᪉ἲ
⥙⭷Ⰽ⣲ኚᛶᝈ⪅ࢆྵࡴᐙ⣔㸯࡜㗹యᱰయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅ࢆྵࡴᐙ⣔㸰࡟ᑐࡋ࡚ :(6
ࢆ⾜ࡗࡓᅗ㸯ࠋྛᝈ⪅࠿ࡽᚓࡽࢀࡓ㑇ఏᏊኚ␗࠿ࡽ᪤▱ࡢ୍ሷᇶከᆺ㢖ᗘࢹ࣮ࢱ࣮࣋ࢫ
࡟ሗ࿌ࡀ࠶ࡿࡶࡢࢆ㝖ࡁࠊࡲࡓ㑇ఏᙧᘧ࡟ࡼࡿ⤠ࡾ㎸ࡳࢆ⾜ࡗࡓࠋཎᅉ㑇ఏᏊೃ⿵࡜࡞ࡗ
ࡓ &RUI ࡢ P51$ ࡜ࢱࣥࣃࢡ㉁ࡀ⥙⭷࡛Ⓨ⌧ࡋ࡚࠸ࡿ࠿࡝࠺࠿ࢆࡑࢀࡒࢀ 573&5 ࡜࢙࢘
― 95 ―
ࢫࢱࣥࣈࣟࢵࢸ࢕ࣥࢢ࡛☜ㄆࡋࡓࠋࡲࡓࠊච␿⤌⧊ᰁⰍ࡟ࡼࡾࢱࣥࣃࢡ㉁ࡢᒁᅾࢆ☜ㄆࡋ
ࡓࠋ㑇ఏᏊኚ␗ࡀᶵ⬟࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ࡟㔝⏕ᆺ㑇ఏᏊ࡜ኚ␗ᆺ㑇ఏᏊࡢ F'1$
ࢆࡑࢀࡒࢀⓎ⌧࣋ࢡࢱ࣮࡟ࢧࣈࢡ࣮ࣟࢽࣥࢢࡋࠊᇵ㣴⣽⬊࡛Ⓨ⌧ࡉࡏ࡚Ⓨ⌧㔞ࢆ᳨ウࡋࡓࠋ
⤖ ᯝ
⥙⭷Ⰽ⣲ኚᛶᝈ⪅㸦ࠊ㸧࡜㗹యᱰయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅㸦㸧࠿ࡽ &RUI 㑇ఏ
Ꮚࡢ」ྜ࣊ࢸࣟኚ␗㸦S90S<+㸧࡜ຎᛶ࣍ࣔኚ␗㸦S<&㸧ࢆྠᐃࡋࡓ㸦ᅗ㸯㸧ࠋ
ᅗ䠍㻌 ⥙⭷Ⰽ⣲ኚᛶᝈ⪅ᐙ⣔䠄㻲㼍㼙㼕㼘㼥㻌 㻝䠅䛸㗹యᮞయ䝆䝇䝖䝻䝣䜱䞊ᝈ⪅ᐙ⣔䠄㻲㼍㼙㼕㼘㼥㻌
㻞䠅䚹㯮ሬ䜚䛿Ⓨ⑕⪅䜢♧䛩䚹䜰䝇䝍䝸䝇䜽䛷♧䛥䜜䛯ಶே䛾䝀䝜䝮䛻ᑐ䛧䛶඲䜶䜽䝋䞁
ゎᯒ䜢⾜䛳䛯䚹ୗ䛻グ㍕䛥䜜䛶䛔䜛䛾䛿 㻯㻞㻝㼛㼞㼒㻞 䛾䜰䝭䝜㓟ኚ␗䚹㻌
&RUI ࡣ ᖺ࡟㗹యᱰయࢪࢫࢺࣟࣇ࢕࣮ࢆక࠺࿧྾୙඲ᛶ⬚㒌␗ᙧᡂ⑕ࡢཎᅉ㑇ఏ
Ꮚ࠾ࡼࡧ㯤ᩬ㒊ࡢ␗ᖖࢆక࠺⥙⭷ኚᛶࡢཎᅉ㑇ఏᏊ࡜ࡋ࡚ሗ࿌ࡉࢀ࡚࠸ࡓࠋ㗹యᮞయࢪࢫ
ࢺࣟࣇ࢕࣮ࡣ㗹యࡢኚᛶࡀඛ⾜ࡍࡿࡢ࡟ᑐࡋࠊ⥙⭷Ⰽ⣲ኚᛶࡣ㏻ᖖᮞయど⣽⬊࠿ࡽኚᛶࡀ
㐍ࡴࠋ⮫ᗋࢹ࣮ࢱ࠿ࡽࡶ )DPLO\࡜ )DPLO\ ࡢ㐪࠸ࡣ᫂ࡽ࠿࡛࠶ࡾࠊ௒ᅇࡢ౛ࡣ &RUI
ࡀཎᅉ࡜࡞ࡿ⥙⭷Ⰽ⣲ኚᛶ࡟ࡘ࠸࡚ࡢ᪂ࡋ࠸ሗ࿌࡜࡞ࡿࠋ
⥙⭷ኚᛶ⑌ᝈࡢཎᅉ㑇
ఏᏊࡢከࡃࡣ⥙⭷࡛Ⓨ⌧
W/ͬϮϭŽƌĨϮͬĂĐdh
W/ͬĂĐdh
ࡋ࡚࠸ࡿࡓࡵࠊ&RUI
㑇ఏᏊ࡟ࡘ࠸࡚ࡶ⥙⭷࡛
KE>
ࡢⓎ⌧ࢆ᳨ウࡋࡓ࡜ࡇࢁࠊ
࣐࢘ࢫ⥙⭷࡛ࡣど⣽⬊ࡢ
ෆ⠇̺እ⠇࡟Ώࡗ࡚ࢱࣥ
/^ͬK^
ࣃࢡ㉁ࡢᒁᅾࡀ☜ㄆࡉࢀ
ࡓ㸦ᅗ㸰㸧ࠋࣄࢺ࡜ྠࡌ㟋
㛗㢮࡛࠶ࡿࢧࣝࡢ⥙⭷⤌
⧊ᰁⰍ࡛ࡶෆ⠇̺እ⠇㒊
ศ࡟ᰁⰍࡀ☜ㄆࡉࢀࡓࠋ
ᅗ䠎㻌 㻯㻞㻝㼛㼞㼒㻞 䝍䞁䝟䜽㉁䛾ᒁᅾ䚹ど⣽⬊ෆ⠇䇲እ⠇䠄㻵㻿㻛㻻㻿䠅䛷
䜰䝉䝏䝹໬䝏䝳䝤䝸䞁䠄㼍㼏㼀㼁㻮㻭䠅䛸୍㒊ඹᒁᅾ䛩䜛䚹㻰㻭㻼㻵 䛷ᰁ
Ⰽ䛥䜜䛶䛔䜛䛾䛿ど⣽⬊䛾᰾䛜䛒䜛⥙⭷እ㢛⢏ᒙ䠄㻻㻺㻸䠅䚹㻌
ど⣽⬊ࡢෆ⠇̺እ⠇࡟ࡣ
⧄ẟᵓ㐀ࡀ࠶ࡾࠊ&RUI ࡀ⧄ẟᙧᡂ࡟ᚲせ࡞ࡇ࡜࡜ᒁᅾࡣࡼࡃྜ⮴ࡋ࡚࠸ࡿࠋࡋ࠿ࡋ௨
๓ࡢሗ࿌࡛ࡣ &RUI ࢱࣥࣃࢡ㉁ࡢᒁᅾࡣ⧄ẟᇶᗏ㒊࡟ࡢࡳⅬ≧࡟ぢࡽࢀ࡚࠾ࡾࠊ௒ᅇࡢ
― 96 ―
⤖ᯝ࡜ࡣᢠయࡢ㐪࠸ࠊࡲࡓ࣐࢘ࢫࡢ㐌㱋࡞࡝ࡀᙳ㡪ࡋ࡚࠸ࡿྍ⬟ᛶࡀ࠶ࡿࠋ
&RUI ࢱࣥࣃ
>ZZĐĂƉ
ࢡ㉁ࡣ 1 ᮎഃ࡟ࣟ
>ZZ >ZZ >ZZ
࢖ࢩࣥࣜࢵࢳࣜࣆ
࣮ࢺ㸦/55㸧ࢆࡶࡘ
zϭϬϳ,
zϭϬϳ
sϭϭϭD
▷࠸ࢱࣥࣃࢡ㉁࡛
࠶ࡿᅗ㸱ࠋࡇࢀ
ࡲ࡛࡟ሗ࿌ࡉࢀ࡚
࠸ࡿ㑇ఏᏊኚ␗ࡀ
/55 㡿ᇦࡸ & ᮎഃ
ϮϱϲĂĂ
ᅗ䠏㻌 㻯㻞㻝㼛㼞㼒㻞 䝍䞁䝟䜽㉁䛾䝗䝯䜲䞁ᵓ㐀䛸ኚ␗䛾఩⨨䚹㻸㻾㻾㻦㻌 䝻䜲䝅䞁䝸
䝑䝏䝸䝢䞊䝖䚹㻌
ࡢ㡿ᇦ࡟఩⨨ࡋ࡚࠸ࡓࡢ࡟ᑐࡋࠊ௒ᅇྠᐃࡋࡓኚ␗ࡣ࠸ࡎࢀࡶ /55FDS ࢻ࣓࢖ࣥ࡜࠸࠺ࢱ
ࣥࣃࢡ㉁ࡢᢡࡾࡓࡓࡳ࡜❧యᵓ㐀ࡢ఩⨨࡟㔜せ࡞㡿ᇦ࡟఩⨨ࡋ࡚࠸ࡓࠋᩥ⊩ⓗ࡟ࡣ <
࡟┦ᙜࡍࡿࢳࣟࢩࣥṧᇶࡣ /55FDS ࡢᮎ➃࡟࠶ࡿ࢔ࢫࣃࣛࢠࣥ㓟࡜Ỉ⣲⤖ྜࢆసࡾࠊ<
࡜ 9 ࡝ࡕࡽ࡟┦ᙜࡍࡿ࢔࣑ࣀ㓟ࢆ௚ࡢ࢔࣑ࣀ㓟࡟⨨᥮ࡋࡓሙྜࡶࢱࣥࣃࢡ㉁ࡢᏳᐃᛶ
ࡀపୗࡍࡿࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡿࠋ
㑇ఏᏊኚ␗ࡀࢱࣥࣃࢡ㉁ᶵ⬟࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ࡟㔝⏕ᆺࢱࣥࣃࢡ㉁࡜ኚ␗ᆺ
ࢱࣥࣃࢡ㉁ࡢⓎ⌧ᐇ㦂ࢆ⾜ࡗࡓ⤖ᯝࠊኚ␗ᆺࢱࣥࣃࢡ㉁ࡣ㔝⏕ᆺࢱࣥࣃࢡ㉁ࡢ༙ศ⛬ᗘࡢ
Ⓨ⌧㔞ࡋ࠿ぢࡽࢀ࡞࠿ࡗ
␗ᖖ࡞ࡓࢇࡥࡃ㉁ࡣ⣽⬊
td
ෆࡢࣘࣅ࢟ࢳ࣭ࣥࣉࣟࢸ
࢔ࢯ࣮࣒ࢩࢫࢸ࣒࡟ࡼࡗ
࡚ศゎࡉࢀࡿࡇ࡜ࡀ▱ࡽ
ࢀ࡚࠸ࡿࠋࢱࣥࣃࢡ㉁ศ
ゎ ࡟ ࡼ ࡗ ࡚ ኚ ␗ ᆺ
zϭϬϳ,
sϭϭϭD
ŵŽĐŬ
ࡓࠋ
&ůĂŐ
d
&RUI ࡢࢱࣥࣃࢡ㉁㔞
ࡀᑡ࡞ࡃ࡞ࡗ࡚࠸ࡿࡢ࠿
࡝࠺࠿ࢆ☜࠿ࡵࡿࡓࡵ࡟ࠊ
ࣉࣟࢸ࢔ࢯ࣮࣒㜼ᐖ๣ࢆ
ῧຍࡋࡓ≧ែ࡛ࢱࣥࣃࢡ
ᅗ䠐㻌 㔝⏕ᆺ䛸ኚ␗ᆺ 㻯㻞㻝㼛㼞㼒㻞 䝍䞁䝟䜽㉁䛾Ⓨ⌧㔞ẚ㍑䚹ᕥ䛿
௦⾲ⓗ䛺౛䚸ྑ䛿 㻟 㝵䛾ᐇ㦂䛾ᖹᆒ್䚹Ⓨ⌧㔞䛿䜰䜽䝏䞁䛾
Ⓨ⌧㔞䛷ᖹᆒ໬䛧䛶䛔䜛䚹㻌
㉁㔞ࢆẚ㍑ࡍࡿᐇ㦂ࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊࣉࣟࢸ࢔ࢯ࣮࣒㜼ᐖ๣Ꮡᅾୗ࡛ࡣ <+ ኚ␗య
ࡢࢱࣥࣃࢡ㉁㔞ࡀᅇ᚟ࡍࡿഴྥࡀぢࡽࢀࡓࠋ
ࡇࢀࡽࡢ⤖ᯝ࠿ࡽࠊ⥙⭷Ⰽ⣲ኚᛶᝈ⪅࠾ࡼࡧ㗹యᱰయࢪࢫࢺࣟࣇ࢕࣮ᝈ⪅࠿ࡽྠᐃࡉࢀ
ࡓ &RUI 㑇ఏᏊࡢኚ␗ࡣࢱࣥࣃࢡ㉁ࡢᏳᐃᛶࢆపୗࡉࡏࠊ&RUI ࡢ୙㊊࡟ࡼࡾど⣽⬊
ࡢᶵ⬟࡟㔜せ࡞⧄ẟᙧᡂ࣭⥔ᣢࡀ␗ᖖ࡟࡞ࡾど⣽⬊ࡢኚᛶࢆᘬࡁ㉳ࡇࡍ࡜⪃࠼ࡽࢀࡓࠋ
ᮏ◊✲⤖ᯝࡣ⌧ᅾㄽᩥᢞ✏୰࡛࠶ࡿࠋ
― 97 ―
ࠝศᏊ⣽⬊⏕≀Ꮫ◊✲㒊ࠞ
21 ᆺ཮ᴟ⣽⬊␗ᖖࢆక࠺㯤ᩬኚᛶᐙ⣔ࡢཎᅉ㑇ఏᏊゎᯒ
ᕝᮧ㞝୍ ࠊ⸨ᕳᣅ㑻 ࠊྜྷṊ࿴ᩄ ࠊゅ⏣࿴⦾㸲ࠊᮧୖ ᬗ ࠊᒾ⏣ ᓅ 㸦 ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊ࠊ 㡰ኳᇽ኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉║⛉Ꮫㅮᗙࠊ ᪥ᮏࢯࣇࢺ࢙࢘࢔ࠊ
㸲
どぬ◊✲㒊㸧
せ ⣙
㡰ኳᇽ኱Ꮫ║⛉ࢆཷデ୰ࡢᖖᰁⰍయඃᛶ㑇ఏᙧᘧࢆ࡜ࡿ㯤ᩬࢪࢫࢺࣟࣇ࢕࣮ᐙ⣔࡟ࠊ&5;ࠊ
,03'+ࠊ$,3/ࠊ/&$ ࡞࡝ࡢ᪤▱㯤ᩬኚᛶཎᅉ㑇ఏᏊኚ␗ࡀㄆࡵࡽࢀ࡞࠸ࢣ࣮ࢫࡀ࠶ࡗࡓ
ࡓࡵࠊᮏᐙ⣔࡟࠾ࡅࡿ㯤ᩬࢪࢫࢺࣟࣇ࢕࣮ࡢ᪂つኚ␗࠶ࡿ࠸ࡣ᪂つ㑇ఏᏊࡢ᥈⣴ࢆ┠ⓗ࡜
ࡋ࡚ࠊᮏᐙ⣔ࡢ㑇ఏᏊゎᯒࢆ⾜ࡗࡓࠋᮏᐙ⣔㸱ୡ௦ィ㸶ྡ࠿ࡽၚᾮࢆᥦ౪㡬ࡁࠊࢤࣀ࣒ '1$
ࢆᢳฟࡋࠊH[RPH ゎᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ㸱✀㢮ࡢೃ⿵㑇ఏᏊࡲ࡛⤠ࡾ㎸ࡳࠊࡇࡢ࠺ࡕ
᭱ࡶྍ⬟ᛶ࡜ࡋ࡚㧗࠸㸯✀㢮ࡢ㑇ఏᏊ ; ࡟ࡘ࠸࡚ࠊ⥙⭷࡟࠾ࡅࡿⓎ⌧ゎᯒࢆ⾜ࡗࡓࠋࡑࡢ
⤖ᯝࠊ㑇ఏᏊ ; ࡣ࣐࢘ࢫ࠾ࡼࡧ࢝ࢽࢡ࢖ࢨࣝ⥙⭷ࡢࢩࢼࣉࢫ࡛Ⓨ⌧ࡋ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡾࠊ
ࡑࡢ⏘≀࡛࠶ࡿ⺮ⓑ㉁ ; ࡣ࣐࢘ࢫ⥙⭷࡟࠾࠸࡚⥙⭷ࢩࢼࣉࢫᙧᡂᮇࢆቃ࡟ⴭࡋࡃୖ᪼ࡍࡿ
ࡇ࡜ࡀࢃ࠿ࡗࡓࠋࡲࡓࠊ⺮ⓑ㉁ ; ࢆච␿⤌⧊໬ᏛᰁⰍࡋࡓ࡜ࡇࢁࠊ࣐࢘ࢫ࡜࢝ࢽࢡ࢖ࢨࣝ
⥙⭷ษ∦ࡢ཮᪉࡛እ⥙≧ᒙ࡟ࢩࢼࣉࢫ⺮ⓑ㉁ᵝࡢࣃࢱ᳨࣮࡛ࣥฟࡍࡿࡇ࡜ࡀ࡛ࡁࠊྛ✀⣽
⬊࣐࣮࣮࢝ࢆ౑ࡗ࡚ඹᰁⰍࡋࡓ⤖ᯝࠊ⺮ⓑ㉁ ; ࡣ 21 ᆺ཮ᴟ⣽⬊ࡢど⣽⬊ഃࡢࢩࢼࣉࢫ࡟≉
␗ⓗ࡟ᒁᅾࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ௨ୖࡼࡾࠊ㑇ఏᏊ ; ࡣ့ஙື≀ࡢ⥙⭷࡛Ⓨ⌧
ࡋ࡚࠾ࡾࠊ⥙⭷ࢩࢼࣉࢫ࡟ఱࡽ࠿ࡢᶵ⬟ࢆᯝࡓࡋ࡚࠸ࡿࡇ࡜ࡀ♧ࡉࢀࠊᮏኚ␗ࡀᮏ⑌ᝈ࡟
㛵୚ࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡓࠋ
◊✲┠ⓗ
㯤ᩬࢪࢫࢺࣟࣇ࢕࣮ࡣࠊ/HEHU ඛኳ┣ࡸ 6WDUJDUGW ⑓࡞࡝ࡀ࠶ࡾࠊཎᅉ㑇ఏᏊኚ␗࡟ࡘ
࠸࡚᫂ࡽ࠿࡟ࡉࢀ࡚ࡁ࡚࠸ࡿࠋࡇࡢᗘࠊᖖᰁⰍయඃᛶ㑇ఏᙧᘧࢆ࡜ࡿ㯤ᩬࢪࢫࢺࣟࣇ࢕࣮
ᐙ⣔㸦ᅗ㸯㸧ࡀ㡰ኳᇽ኱Ꮫ║⛉ࢆཷデࡋࠊ㯤ᩬኚᛶཎᅉ㑇ఏᏊࡢ &5;ࠊ,03'+ࠊ$,3/ࠊ/&$
࡞࡝ࡢ㑇ఏᏊ᳨ᰝࡀᐇ᪋ࡉࢀࡓࠋࡋ࠿ࡋࠊࡇࢀࡽࡢ㑇ఏᏊ࡟ከᆺࡣㄆࡵࡓࡶࡢࡢ᪤▱ࡢཎ
ᅉ㑇ఏᏊኚ␗ࡣぢࡽࢀ࡞࠿ࡗࡓࠋࡑࡢࡓࡵࠊᮏᐙ⣔࡟࠾ࡅࡿཎᅉ㑇ఏᏊࡀ᪂つࡢኚ␗࠶ࡿ
࠸ࡣ᪂つ㑇ఏᏊ࡛࠶ࡿྍ⬟ᛶࡀ㧗ࡃ࡞ࡾࠊཎᅉ㑇ఏᏊࡢࢫࢡ࣮ࣜࢽࣥࢢࢆヨࡳࡿࡇ࡜࡜࡞
ࡗࡓࠋᡃࠎࡣࡍ࡛࡟ࠊࡇࡢᐙ⣔㸱ୡ௦ࡢࢤࣀ࣒ '1$ ࢆ඲ H[RQ 㓄ิゎᯒ㸦H[RPH ゎᯒ㸧ࡋ࡚ࠊ
ᮏᐙ⣔࡟࠾ࡅࡿ㯤ᩬኚᛶ≉␗ⓗ࡞᪂つ㑇ఏᏊ ; ࡢኚ␗ࢆྠᐃࡋࡓࠋ
ࡇࡢ㑇ఏᏊ ; ࡢኚ␗࡟ࡘ࠸࡚ࡼࡾヲ⣽࡟ゎᯒࡋࠊᮏኚ␗࡜ᮏ⑌ᝈⓎ⑕࡟㛵ࡍࡿศᏊᶵᵓ
ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚◊✲ࢆ⾜ࡗࡓࠋ㑇ఏᏊ ; ࡣ⬨᳝ື≀ࡢ⬻⚄⤒࡟࠾࠸࡚ࢩ
ࢼࣉࢫᙧᡂ࡟㔜せ࡞ࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊࡑࡢ⏘≀࡛࠶ࡿ⺮ⓑ㉁ ; ࡣࢩࢼࣉࢫᚋ⣽⬊࡜๓
⣽⬊ࡢศ໬ไᚚࢆᢸࡗ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡗ࡚࠸ࡿࠋᮏᖺᗘࡣࠊ㑇ఏᏊ ; ࡢࠊ⥙⭷࡟࠾ࡅࡿ
Ⓨ⌧࡜ᒁᅾ࡟ࡘ࠸࡚ヲ⣽࡟ゎᯒࢆ⾜ࡗࡓࠋࡉࡽ࡟ࠊᝈ⪅ (5* ࢆ ᐃࡋࠊ⥙⭷ෆᒙࡢ␗ᖖ࡟
ࡘ࠸࡚ࡶ᳨ウࡋࡓࠋ
― 98 ―
᪉ ἲ
⏕ᚋ㸮ࠊ㸵ࠊࠊ ᪥┠ࡢ࣐࢘ࢫ
⥙⭷࠿ࡽ⺮ⓑ㉁ᢳฟᾮࢆㄪ〇ࡋࠊ⺮ⓑ
㉁ ; ࡟ᑐࡍࡿᢠయࢆ⏝࠸ࡓ࢙࢘ࢫࢱࣥ
ࣈࣟࢵࢸ࢕ࣥࢢࢆ⾜࠸ࠊ⺮ⓑ㉁ࣞ࣋ࣝ
࡛ࡢⓎ⌧ࢆ☜ㄆࡋࡓࠋࡇࡢ࡜ࡁᚓࡽࢀ
ࡓࣂࣥࢻࡢ⃰ࡉࢆ ,PDJH- ࢆ౑⏝ࡋ࡚
ᐃ㔞໬ࡋࠊྛࢫࢸ࣮ࢪ࡟࠾ࡅࡿ⺮ⓑ㉁
; ࡢⓎ⌧㔞ࢆẚ㍑ࡋࡓࠋࡲࡓࠊ࢝ࢽࢡ
࢖ࢨࣝ⥙⭷ࡢ⺮ⓑ㉁ᢳฟ≀ࢆ⏕໬Ꮫⓗ
࡟ศ⏬ࡋ࡚ࢩࢼࣉࢫ㢛⢏⏬ศࢆㄪ〇ࡋࠊ
ࡇࢀࡶ࢙࢘ࢫࢱࣥࣈࣟࢵࢺ࡟ࡼࡗ࡚ゎ
ᯒࡋࠊ⺮ⓑ㉁ ; ࡢศᕸࢆ⏕໬Ꮫⓗ࡟᳨
ドࡍࡿࡇ࡜ࢆヨࡳࡓࠋࡉࡽ࡟ࠊ࣐࢘ࢫ
ᅗ㸯 ᐙ⣔ᅗ
NCMD ࢆ␲ࢃࢀࡓᝈ⪅ࡢᐙ⣔ࠋᖖᰁⰍయඃᛶ㑇
ఏᙧᘧࡢⓎ⑕࡛࠶ࡿࡇ࡜ࠋⓎ➃⪅ III-2ࠋExome
ゎᯒᑐ㇟⪅ࡣ I-1,2,3,5, II-1,2, III-1,2 ࡛࠶ࡿࠋ
ࡲࡓࡣ࢝ࢽࢡ࢖ࢨࣝࡢ║⌫ࢆ㸲㸣ࣃ࣒ࣛ࣍ࣝ࢔ࣝࢹࣄࢻ࡛ᅛᐃࡋ࡚෾⤖ษ∦ࢆస〇ࡋࠊᢠ
⺮ⓑ㉁ ; ᢠయࡸ཮ᴟ⣽⬊࣐࣮࣮࢝➼ࡢྛ✀࣐࣮࣮࢝ᢠయ࡜ඹ࡟ච␿⤌⧊໬ᏛᰁⰍࢆ⾜࠸ࠊ
ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾࡛ほᐹࡋࡓࠋ୍᪉ࠊᝈ⪅ࡢ⥙⭷ෆᒙ࡟࠾ࡅࡿ㞀ᐖ࡟ࡘ࠸࡚ㄪ࡭ࡿࡓ
ࡵࠊᙜ㝔࡟࡚඲ど㔝⥙⭷㟁ᅗ㸦(5*㸧ࢆᱰయ཯ᛂ࣭ᱰయ㗹య཯ᛂ࣭㗹య཯ᛂ࣭IOLFNHU࣭㛗
ᮇ㛫ග่⃭࡟ࡘ࠸࡚ ᐃࡋࡓࠋ
⤖ ᯝ
㑇ఏᏊ ; ࡀ⥙⭷࡛Ⓨ⌧ࡋ࡚࠸ࡿ࠿࡝࠺࠿☜ㄆࡍࡿࡓࡵࠊ(3 㐌㱋㸦:㸧ࡢྛ࣐࢘
ࢫ࡜࢝ࢽࢡ࢖ࢨࣝࡢ⥙⭷ 51$ ࢆ 573&5 ࡋ࡚ゎᯒࡋࡓ㸦ᅗ㸰$㸧
ࠋࡑࡢ⤖ᯝࠊ࣐࢘ࢫࡢྛ㐌㱋
࠾ࡼࡧ࢝ࢽࢡ࢖ࢨࣝ⥙⭷࡛㑇ఏᏊ ; ࡢⓎ⌧ࢆ☜ㄆࡋࡓࠋࡉࡽ࡟ࠊ㑇ఏᏊ ; ࡢ㑇ఏᏊ⏘≀࡜
ࡋ࡚ࠊ⺮ⓑ㉁ ; ࡀ⥙⭷ࡢ⺮ⓑ㉁ᢳฟ≀୰࡟ྵࡲࢀ࡚࠸ࡿ࠿࡝࠺࠿☜ㄆࡍࡿࡓࡵࠊ⏕ᚋ㸮᪥
┠㸦3㸧ࠊ㸵᪥┠㸦3㸧ࠊ ᪥┠㸦3㸧ࠊ ᪥┠㸦3㸧ࡢ࣐࢘ࢫ⥙⭷࠿ࡽ⺮ⓑ㉁ᢳฟ≀ࢆ
ㄪ〇ࡋࠊ࢙࢘ࢱࣥࣈࣟࢵࢸ࢕ࣥࢢ࡟ࡼࡿゎᯒࢆヨࡳࡓ㸦ᅗ㸰%㸧ࠋࡑࡢ⤖ᯝࠊ࣐࢘ࢫࡢ⥙⭷
ᢳฟ≀୰ࡼࡾ⺮ⓑ㉁ ; ࢆ᳨ฟࡋࡓࠋࡉࡽ࡟⺮ⓑ㉁ ; ࡢࣂࣥࢻࢆᐃ㔞໬ࡋࡓ࡜ࡇࢁࠊ3 ࠿ࡽ
3 ࡢ⥙⭷ࢩࢼࣉࢫᙧᡂᮇࢆቃ࡟ⴭࡋࡃ⺮ⓑ㉁㔞ࡀୖ᪼ࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࠊ⺮
ⓑ㉁ ; ࡀ⥙⭷ࢩࢼࣉࢫࡢᙧᡂ࡜⥔ᣢ࡟࠾࠸࡚㠀ᖖ࡟㔜せ࡞ᙺ๭ࢆᢸࡗ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉ
ࢀࡓ㸦ᅗ &㸧
ࠋࡲࡓࠊ⺮ⓑ㉁ ; ࡣࢩࢼࣉࢫ࡟Ⓨ⌧ࡋ࡚࠸ࡿ⺮ⓑ㉁࡛࠶ࡿࡓࡵࠊ࢝ࢽࢡ࢖ࢨ
ࣝ⥙⭷ᢳฟ≀ࢆ⏕໬Ꮫⓗᡭἲ࡟ࡼࡾศ⏬ࡋࠊ᰾⏬ศ࣭୰㛫⏬ศ࣭ࢩࢼࣉࢫ㢛⢏⏬ศ࡟ศࡅ
࡚࢙࢘ࢫࢱࣥࣈࣟࢵࢺࡋࡓࠋࡑࡢ⤖ᯝࠊ⺮ⓑ㉁ࡣ⥙⭷࡟࠾࠸࡚ࡶࢩࢼࣉࢫ㢛⢏⏬ศ࡟㇏ᐩ
࡟Ꮡᅾࡋ࡚࠸ࡿࡇ࡜ࡀ⏕໬Ꮫⓗ࡟᫂ࡽ࠿࡜࡞ࡗࡓ㸦ᅗ '㸧ࠋࡉࡽ࡟ࠊ࣐࢘ࢫ⥙⭷ษ∦ࢆ⺮
ⓑ㉁ ; ᢠయ࡛ච␿ᰁⰍࡋࠊ⥙⭷ࡢ࡝ࡢ㒊ศࡢࢩࢼࣉࢫ࡟ᒁᅾࡋ࡚࠸ࡿ࠿☜࠿ࡵࡓࠋࡑࡢ⤖
ᯝࠊ⺮ⓑ㉁ ; ࡣ⏕໬Ꮫⓗᡭἲ࡛᫂ࡽ࠿࡟ࡋࡓ㏻ࡾ㸦ᅗ '㸧
ࠊእ⥙≧ᒙ㸦23/㸧ࡢࢩࢼࣉࢫᙧ
ᡂ㒊఩࡟ࢩࢼࣉࢫᵝࡢᙧែ᳨࡛ฟࡉࢀࠊⓎ⏕ẁ㝵ࡈ࡜࡟Ⓨ⌧㔞ࢆゎᯒࡋࡓ࢙࢘ࢫࢱࣥࣈࣟ
ࢵࢺࡢ⤖ᯝࡢ㏻ࡾ㸦ᅗ %&㸧ࠊ3 ௨㝆ࡢ⥙⭷ࢩࢼࣉࢫᙧᡂࡀ᏶஢ࡋࡓษ∦࡛ࡢࡳ᳨ฟࡉࢀ
ࡓ㸦ᅗ (㸧ࠋ
― 99 ―
௨ୖࡼࡾࠊ⥙⭷࡛ࡢ㑇ఏᏊ ; ࡢⓎ⌧࠾ࡼࡧࡑࡢ⏘≀࡛࠶ࡿ⺮ⓑ㉁ ; ࡀ⥙⭷ࡢࢩࢼࣉࢫ࡟
ᒁᅾࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
ḟ࡟ࠊ⺮ⓑ㉁ ; ࡀ࡝ࡢ⣽⬊ࡢࢩࢼࣉࢫ࡛Ⓨ⌧ࡋࠊᶵ⬟ࡋ࡚࠸ࡿࡢ࠿ゎᯒࡍࡿࡓࡵࠊ࣐࢘
ࢫ࡜࢝ࢽࢡ࢖ࢨ
ࣝࡢ⥙⭷ษ∦ࢆ
⏝࠸ࡓච␿⤌⧊
໬ᏛᰁⰍࢆ⾜ࡗ
ࡓ㸦ᅗ㸱㸧ࠋࡣࡌ
ࡵ࡟ど⣽⬊ᮎ➃
ࡢ࣐࣮࣮࡛࢝࠶
ࡿ 36' ᢠయ࡜
ᱰయ཮ᴟ⣽⬊࣐
࣮࣮࢝ࡢ 3.&Ș
ᢠయ࡛ච␿ᰁⰍ
ࡋࡓࠋࡑࡢ⤖ᯝࠊ
࣐࢘ࢫ࠾ࡼࡧ࢝
ࢽࢡ࢖ࢨࣝࡢ୧
᪉࡟࠾࠸࡚ࠊ⺮
ⓑ㉁ ; ࡀ཮ᴟ⣽
⬊࣐࣮࣮࢝ࡢᰁ
Ⰽീ࡜㔜࡞ࡿ఩
⨨࡟᳨ฟࡉࢀࡿ
ࡇ࡜ࢆぢฟࡋࡓ
㸦ᅗ㸱$ࠊⓑ▮༳
ࡢࢻࢵࢺ㸧ࠋࡉࡽ
࡟ࠊ⺮ⓑ㉁ ; ࡀ
ࢩࢼࣉࢫᙧᡂ㒊
఩࡟ᒁᅾࡋ࡚࠸
ࡿ࠿࡝࠺࠿ㄪ࡭
ࡿࡓࡵࠊ21 ᆺ཮
ᴟ⣽⬊ࢩࢼࣉࢫ
࣐ ࣮ ࢝ ࣮ ࡢ
P*OX5 ᢠ య ࡜
ど⣽⬊ 21 ᆺࢩ
ࢼࣉࢫ࣐࣮࣮࢝
࡛࠶ࡿ &W%3 ᢠ
య࡜ඹ࡟ච␿ᰁ
Ⰽࡋࡓࠋࡇࡢඹ
ᰁⰍ࡟ࡼࡾࠊ⺮
ᅗ㸰 ࣐࢘ࢫ࠾ࡼࡧ࢝ࢽࢡ࢖ࢨࣝ⥙⭷࡟࠾ࡅࡿ
㑇ఏᏊ X ࡢⓎ⌧ゎᯒ
E16, P7, 5 㐌㱋㸦5W㸧࣐࢘ࢫ࡜࢝ࢽࢡ࢖ࢨࣝࡢ⥙⭷ RNA ࡟࠾ࡅ
ࡿ RT-PCR ࡟ࡼࡾࠊ㑇ఏᏊ X ࡀ࣐࢘ࢫࡢྛ㐌㱋࠾ࡼࡧ࢝ࢽࢡ࢖
ࢨࣝ⥙⭷࡛Ⓨ⌧ࡋ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡗࡓ㸦A㸧ࠋࡉࡽ࡟ࠊ⥙⭷࡟࠾
ࡅࡿ⺮ⓑ㉁ X ࡢⓎ⌧ࡀⓎ⏕ẁ㝵ⓗ࡟࡝ࡢࡼ࠺࡟ኚ໬ࡍࡿ࠿ㄪ࡭
ࡿࡓࡵࠊP0, P7, P21, P60 ࣐࢘ࢫ⥙⭷ᢳฟ≀ࢆ࢙࢘ࢫࢱࣥࣈࣟࢵ
ࢺ࡟ࡼࡗ࡚ゎᯒࡋࡓ㸦B㸧ࠋ࡞࠾ࠊ࣐࢘ࢫࡢ⬻ࢧࣥࣉࣝࡣ࣏ࢪࢸ࢕
ࣈࢥࣥࢺ࣮ࣟࣝࠊ⭈⮚ࢧࣥࣉࣝࡣࢿ࢞ࢸ࢕ࣈࢥࣥࢺ࣮ࣟࣝ࡜ࡋ࡚
౑⏝ࡋࡓࠋ᳨ฟࡋࡓࣂࣥࢻࢆᐃ㔞໬ࡋ࡚Ⓨ⏕ẁ㝵ࡈ࡜࡟ẚ㍑ࡋࡓ
⤖ᯝࠊ࣐࢘ࢫ⥙⭷࡟࠾࠸࡚ P7 ࠿ࡽ P21 ࡟࠿ࡅ࡚᭷ព࡟⺮ⓑ㉁㔞
ࡀቑຍࡋ࡚࠸ࡓ㸦*:p<0.05㸧㸦C㸧ࠋࡉࡽ࡟࢝ࢽࢡ࢖ࢨࣝ⥙⭷ᢳฟ
≀ࢆ᰾⏬ศ࡜ࢩࢼࣉࢫ㢛⢏⏬ศ㸦୰㛫⏬ศࢆ S2, S3 ࡛♧ࡍ㸧࡟
ศࡅ࡚࢙࢘ࢫࢱࣥࣈࣟࢵࢺ࡟ࡼࡗ࡚⺮ⓑ㉁ X ࢆ᳨ฟࡋࡓ⤖ᯝࠊࢩ
ࢼࣉࢫ㢛⢏⏬ศ࡟࡚㇏ᐩ࡟ X ࢆ᳨ฟࡋࡓ㸦D㸧ࠋ࣐࢘ࢫ⥙⭷ษ∦
ࢆ⏝࠸࡚⺮ⓑ㉁ X ࡟ᑐࡍࡿච␿ᰁⰍࢆ⾜ࡗࡓ⤖ᯝࠊP21 ௨㝆ࡢ࣐
࢘ࢫ⥙⭷ࡢእ⥙≧ᒙ㸦OPL㸧࡟ࢩࢼࣉࢫ⏝ࡢࢻࢵࢺ≧ࡢࢩࢢࢼࣝ
࡜ࡋ᳨࡚ฟ࡛ࡁࡓ㸦E㸧ࠋ
ⓑ㉁ ; ࡢ
― 100 ―
ࢩࢢࢼࣝࡣᱰయࢩࢼ
ࣉࢫᙧᡂ㒊఩࡟఩⨨
ࡍࡿ 21 ᆺ཮ᴟ⣽⬊
ࢩࢼࣉࢫ࣐࣮࣮࢝࡜
᏶඲࡟୍⮴ࡋࡓ㸦ᅗ
㸱%ࠊⓑ▮༳ࡀ♧ࡍࢻ
ࢵࢺ㸧ࠋ୍᪉ࠊ㗹యࢩ
ࢼࣉࢫᙧᡂ㒊఩ࡢ
21 ᆺ཮ᴟ⣽⬊ࢩࢼ
ࣉࢫࡢࢩࢢࢼࣝ࡜ࡣ
㔜࡞ࡽ࡞࠸ࡇ࡜࠿ࡽ
㸦ᅗ㸱%ࠊ㯮▮༳ࡀ♧
ࡍࢻࢵࢺࡢ࠿ࡓࡲ
ࡾ㸧ࠊ⺮ⓑ㉁ ; ࡣ 21
ᆺ཮ᴟ⣽⬊ࡢᱰయࢩ
ࢼࣉࢫ࡟≉␗ⓗ࡟ᒁ
ᅾࡋ࡚࠸ࡿࡇ࡜ࡀ᫂
ࡽ࠿࡜࡞ࡗࡓࠋࡲࡓࠊ
࢝ࢽࢡ࢖ࢨࣝ࡟࠾࠸
࡚ࡣど⣽⬊ࡢᱰయ⣽
⬊࡜㗹య⣽⬊ࡢศᕸ
ᐦᗘࡀ⥙⭷ࡢ୰ᚰ௜
㏆࡜࿘㎶㒊࡛␗࡞ࡿ
ࡓࡵࠊࡇࢀࡽࡢ㐪࠸
࡟ࡼࡿ⺮ⓑ㉁ ; ࡢᒁ
ᅾ࡟ኚ໬ࡀ࠶ࡿ࠿࡝
࠺࠿☜࠿ࡵࡿࡓࡵࠊ
⥙⭷ࡢ୰ᚰ㒊࡜࿘㎶
㒊ࢆࡑࢀࡒࢀほᐹࡋ
ࡓࡀࠊ௒ᅇ⾜ࡗࡓほ
ᐹ࡟࠾࠸࡚ࡣ୰ᚰ㒊
࡜࿘㎶㒊࡟ࡼࡿ⺮ⓑ
㉁ ; ࡢᒁᅾࣃࢱ࣮ࣥ
ࡢኚ໬ࡣぢฟࡏ࡞࠿
ࡗࡓࠋ
⺮ⓑ㉁ ; ࡀ 21 ᆺ཮
ᴟ⣽⬊࡛Ⓨ⌧ࡋ࡚࠸
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞
ࡾࠊᡃࠎࡣ⺮ⓑ㉁ ;
ࡢኚ␗యࡀ 21 ᆺ཮
ᅗ㸱 ࢝ࢽࢡ࢖ࢨࣝ⥙⭷ษ∦࡟࠾ࡅࡿච␿⤌⧊໬ᏛᰁⰍ
ど⣽⬊ᮎ➃࣐࣮࣮࢝㸦PSD95㸧࡜཮ᴟ⣽⬊࣐࣮࣮࢝㸦PKC
Ș㸧࡜ඹ࡟⺮ⓑ㉁ X ࢆච␿ᰁⰍࡋࡓ㸦A㸧ࠋࡑࡢ⤖ᯝࠊⓑ▮
༳ࡀ♧ࡍࡼ࠺࡟⺮ⓑ㉁ X ࡢࢻࢵࢺࡣ཮ᴟ⣽⬊࣐࣮࣮࢝ࡀ♧
ࡍᶞ≧✺㉳ࡢୖ࡟㔜࡞ࡗ࡚ぢ࠼ࡓࠋON ᆺ཮ᴟ⣽⬊ࢩࢼࣉ
ࢫ࣐࣮࣮࢝㸦mGluR6㸧࡜ど⣽⬊ ON ᆺࢩࢼࣉࢫ࣐࣮࣮࢝
㸦CtBP2㸧࡜ඹ࡟ච␿ᰁⰍࡍࡿ࡜ࠊ⺮ⓑ㉁ X ࡢࢻࢵࢺࡣⓑ
▮༳࡛♧ࡋࡓᱰయࢩࢼࣉࢫࡢ཮ᴟ⣽⬊ഃࡢࢩࢼࣉࢫ࣐࣮࢝
࣮࡜㔜࡞ࡾࠊ⺮ⓑ㉁ X ࡣ ON ᆺ཮ᴟ⣽⬊ࡢᱰయࢩࢼࣉࢫ࡟
ᒁᅾࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ୍᪉ࠊ㯮▮༳ࡀ♧ࡍ
㗹యࢩࢼࣉࢫഃ࡟⺮ⓑ㉁ X ࡢࢩࢢࢼࣝࡣ↓࠸ࠋྛษ∦ඹ࡟
୰ ᚰ ௜ ㏆ 㸦 center 㸧 ࡜ ୰ 㛫 㒊 㸦 cent.-peri. 㸧 ࡜ ࿘ ㎶ 㒊
㸦periphery㸧ࢆࡑࢀࡒࢀほᐹࡋࡓࠋ
እ㢛⢏ᒙ㸸ONL, እ⥙≧ᒙ㸸OPL, ෆ㢛⢏ᒙ㸸INL, ෆ⥙
≧ᒙ㸸IPLࠋ
― 101 ―
ᴟ⣽⬊࡛ఱࡽ࠿ࡢ␗ᖖࢆⓎ⏕ࡉࡏ࡚ኚᛶ࡟⮳ࡾࠊࡑࡇ࡟᥋⥆ࡋ࡚࠸ࡓど⣽⬊࠿ࡽࡢ㟁Ẽࢩ
ࢢࢼࣝࡢఏ㐩ࡀࡿࡇ࡜࡟ࡼࡗ࡚ど⣽⬊ࡲ࡛ኚᛶࡀᣑ኱ࡍࡿࡇ࡜࡛ࠊᮏ⑌ᝈࡀⓎ⑕ࡋ࡚࠸
ࡓࡢ࡛ࡣ࡞࠸࠿࡜௬ᐃࡋࡓࠋࡑࡇ࡛ࠊᝈ⪅ࡢ⥙⭷㟁ᅗࢆ ᐃࡋ࡚ࠊ⥙⭷ෆᒙ࡟࠾ࡅࡿ㟁Ẽ
ఏ㐩➼ࡢࢹ࣮ࢱ࠿ࡽ཮ᴟ⣽⬊࡞࡝ࡢ஧ḟࢽ࣮ࣗࣟࣥ࡟㞀ᐖࡀ㉳ࡇࡗ࡚࠸ࡿࡇ࡜ࡀ᳨ฟ࡛ࡁ
࡞࠸࠿ࠊᝈ⪅࡟ࡈ༠ຊࡢୖ࡛ヨࡳࡓࠋࡑࡢ⤖ᯝࠊᝈ⪅ ,,ࠊ,,ࠊ,,, ࡢ㸱ே࡛ᱰయ཯
ᛂࡀ኱ᖜ࡟ῶ⾶ࡋ࡚࠸ࡓࠋࡲࡓࠊẚ㍑ⓗ⑕≧ࡢ㐍⾜ࡀ⦆ᚎ࡞ ,, ࡟࠾࠸࡚ࡣ IOLFNHU(5*
࡛ࢃࡎ࠿࡞ࡀࡽ࡟ᛂ⟅ࡀぢࡽࢀࠊ㛗ᮇ㛫ග่⃭࡟ࡼࡿ᫂㡰ᛂ (5* ࡛ࡣ 21 ᆺ཮ᴟ⣽⬊⏤᮶ࡢ
E Ἴࡣῶ⾶ࡋ࡚࠸ࡿ࡟ࡶ࠿࠿ࢃࡽࡎࠊ2)) ᆺ཮ᴟ⣽⬊⏤᮶ࡢ G Ἴࡣ᳨ฟࡉࢀࡿ࡜࠸࠺㠀ᖖ࡟
⌋ࡋ࠸ഴྥࢆ♧ࡋࡓࠋ
௨ୖࡢᝈ⪅ (5* ࡢ⤖ᯝࡼࡾࠊ21 ᆺ཮ᴟ⣽⬊ࡢ␗ᖖࢆక࠺ࠊ࠶ࡿ࠸ࡣⓎ➃࡜࡞ࡿど⣽⬊ኚ
ᛶࢆᘬࡁ㉳ࡇࡍ㠀ᖖ࡟⌋ࡋ࠸⾲⌧ᆺࢆ♧ࡍ⑕౛࡛࠶ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋࡲࡓࠊᮏ◊✲࡛ྠ
ᐃࡉࢀࡓ㑇ఏᏊ ; ࡣ 21 ᆺ཮ᴟ⣽⬊ࡢᱰయࢩࢼࣉࢫ࡟≉␗ⓗ࡟ᒁᅾࡋ࡚࠸ࡿࡇ࡜࠿ࡽࠊᮏኚ
␗య࡟ࡼࡗ࡚ࡣࡌࡵ࡟ᱰయ཮ᴟ⣽⬊࠾ࡼࡧᱰయど⣽⬊࡟␗ᖖࡀฟ࡚ࠊࡑࡢᙳ㡪ࡀ㗹యど⣽
⬊࡬Ἴཬࡍࡿࡇ࡜࡛Ⓨ⑕ࡋ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀࡿࠋࡇࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒ࢆ௨ࡗ࡚ど
ᅗ㸲 ᝈ⪅ࡢ⥙⭷㟁ᅗ
ᕥ࠿ࡽ㡰࡟ᱰయ཯ᛂ㸦ᬯ㡰ᛂ㸸rod㸧ࠊᱰయ/㗹య཯ᛂ㸦ᬯ㡰ᛂ㸸rod/cone㸧ࠊ㗹య཯ᛂ㸦᫂
㡰ᛂ㸸cone㸧
ࠊflicker㸦᫂㡰ᛂ㸸flicker㸧ࠊ㛗᫬㛫ග่⃭㸦᫂㡰ᛂ㸸long-flash㸧ࢆ♧ࡍࠋ
೺ᖖ⪅࡛ࡣྛ ERG ࡛≉ᚩⓗ࡞Ἴᙧࢆ♧ࡍࡀ㸦A㸧ࠊᝈ⪅࡛ࡣࡑࢀࡽࡢἼᙧࡀῶ⾶࣭㐜
ࡲࡓࡣ↓࠸ࠋ≉࡟ࠊᝈ⪅ II-1 ࡜ᝈ⪅ III-2 ࡣྛ ERG ࡛࡯࡜ࢇ࡝཯ᛂࡀぢࡽࢀ࡞࠸㸦B,D㸧ࠋ
୍᪉࡛ࠊᝈ⪅ II-2 ࡣ௚ࡢ஧ே࡜ẚ࡭࡚⑕≧ࡀ㍍࠸ࡓࡵࠊ೺ᖖ⪅࡜ẚ࡭኱ᖜ࡞ῶᑡࡀぢࡽ
ࢀࡿࡶࡢࡢ཯ᛂࢆᩓぢ࡛ࡁࡿ㸦C㸧ࠋ≉࡟ࠊ㛗᫬㛫ග่⃭ ERG ࡛ࡣࠊど⣽⬊⏤᮶ࡢἼᙧ
㸦a Ἴ㸸㟷୸㸧࡜ OFF ᆺ཮ᴟ⣽⬊⏤᮶ࡢἼᙧ㸦d Ἴ㸸⥳୸㸧ࡣࡲࡔぢࡽࢀࡿࡶࡢࡢࠊON
ᆺ཮ᴟ⣽⬊⏤᮶ࡢἼᙧࡢࡳῶ⾶ࡋ࡚࠸ࡿ㸦b Ἴ㸸㉥୸㸧ࠋ
― 102 ―
⣽⬊ኚᛶࡸ㯤ᩬኚᛶࢆᘬࡁ㉳ࡇࡍ⑕౛ࡣᴟࡵ࡚⌋ࡋ࠸ࡇ࡜࠿ࡽࠊᮏ⑌ᝈࡣ㑇ఏᏛⓗ࡟ࡶ⑓
⌮Ꮫⓗ࡟ࡶ᪂つࡢ㑇ఏᛶ║⑌ᝈ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋ
௒ᚋࡣࠊ㑇ఏᏊ ; ࡢኚ␗యࡀᮏ⑌ᝈࡢⓎ⑕ࡢཎᅉ࡛࠶ࡿ☜ドࢆᚓࡿࡓࡵࠊࡲࡓᮏ⑌ᝈࡢ
Ⓨ⑕࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡓࡵࠊᮏኚ␗యࢆࣀࢵࢡ࢖ࣥࡋࡓ࣐࢘ࢫࣔࢹ࡛ࣝ⥙⭷࡟࠾ࡅࡿ
⾲⌧ᆺࢆゎᯒࡋ࡚ࠊᮏ㑇ఏᏊ࡜㯤ᩬࢪࢫࢺࣟࣇ࢕࣮ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚⪃ᐹࡋ࡚࠸ࡃணᐃ࡛
࠶ࡿࠋ
ཧ⪃ᩥ⊩
>@-&%ODQNVHWDO͂6\QDSWRJHQHVLVLQWKHSKRWRUHFHSWRUWHUPLQDORIWKHPRXVH
UHWLQD̓-&RPS1HXUROS̽
>@/-)LVKHU͂'HYHORSPHQWRIUHWLQDOV\QDSWLFDUUD\VLQWKHLQQHUSOH[LIRUP
OD\HURIGDUNUHDUHGPLFH̓M(PEU\ROH[S0RUSKS
>@'06KHUU\HWDO͂([SUHVVLRQRIYHVLFXODUJOXWDPDWHWUDQVSRUWHULQWKH
PRXVHUHWLQDUHYHDOVWHPSRUDORUGHULQJLQGHYHORSPHQWRIURGYVFRQHDQG21YV2))
FLUFXLWV̓-&RPS1HXUROS̽
― 103 ―
㻌
㻌
㻌
㻌
䊡㻌 ᴗ⦼㞟䠄Ꮫ఍Ⓨ⾲䚸ㄽᩥ䚸୺ദ䝅䞁䝫䝆䜴䝮䠅㻌
㻌
㻌
㻌
㻞㻜㻝㻡 ᖺᴗ⦼㞟㻌
┠㻌 㻌 ḟ㻌
㻌
䠍䠊ᨻ⟇་⒪௻⏬◊✲㒊㻌㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㻌㻌 105
䠎䠊どぬ◊✲㒊㻌㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㻌㻌 167
䠏䠊⫈ぬ䞉ᖹ⾮ぬ◊✲㒊㻌㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㻌㻌 177
䠐䠊ேᕤ⮚ჾ䞉ᶵჾ㛤Ⓨ◊✲㒊㻌㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㻌㻌 215
䠑䠊ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㻌㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㽂㻌㻌 221
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
ᨻ⟇་⒪௻⏬◊✲㒊㻌
㻌
⮫ᗋ␿Ꮫ◊✲ᐊ
㹙ㄽᩥ㹛
Bito S, Miyata S, Migita K, Nakamura M, Shinohara K, Sato T, Tonai T, Shimizu
M, Shibata Y, Kishi K, Kubota C, Nakahara S, Mori T, Ikeda K, Ota S, Minamizaki
T, Yamada S, Shiota N, Kamei M, Motokawa S
Mechanical prophylaxis is a heparin-independent risk for anti-platelet factor
4/heparin antibody formation after orthopedic surgery
Blood㸸2015.12.9
Impact factor 10.45
Izumi M, Migita K, Nakamura M, Jiuchi Y, Sakai T, Yamaguchi T, Asahara T,
Nishino Y, Bito S, Miyata S, Kumagai K, Osaki M, Mawatari M, Motokawa S
Risk of venous thromboembolism after total knee arthroplasty in patients with
rheumatoid arthritis
J Rheumatol 42(6)㸸928-34㸪2015.6
Impact factor 3.19
Bito S, Yamamoto T, Tominaga H;JAPOAN Investigators
Prospective cohort study comparing the effects of different artificial nutrition
methods on long-term survival in the elderly
Japan Assessment Study on Procedures and Outcomes of Artificial Nutrition
(JAPOAN) 39(4)㸸456-64㸪2015.5
Impact factor 3.15
Saito S, Ito K, Yorozu A, Aoki M, Koga H, Satoh T, Ohashi T, Shigematsu N, Maruo S,
Kikuchi T, Kojima S, Dokiya T, Fukushima M, Yamanaka H
Nationwide Japanese prostate cancer outcomes study of permanent iodine-125 seed
implantation (J-POPS)
Int J Clin Oncol 20㸸375-385㸪2015
Impact factor 2.13
ᩧ⸨ྐ㑻ࠊすᒣᚭࠊ▮ᮌᗣேࠊ୰ᮧ᠇ࠊᑠὠ඙୍㑻ࠊ㟷ᮌၨ௓ࠊᡞ▮࿴ோࠊⴙ⠜᠇
๓❧⭢ࡀࢇ࡟ᑐࡍࡿᨺᑕ⥺἞⒪᭱๓⥺ 2. ᨺᑕ⥺἞⒪ᚋ෌Ⓨ࡟ᑐࡍࡿᑐᛂ
἞⒪෌Ⓨᚋࡢ Salvage Implant
Prostate Journal 2(1)㸸43-50, 201㸪2015
― 105 ―
2) ᨺᑕ⥺
Yorozu A, Kuroiwa N, Takahashi A, Toya K, Saito S, Nishiyama T, Yagi Y, Tanaka T,
Shiraishi Y, Ohashi T
Permanent prostate brachytherapy with or without supplemental external beam
radiotherapy as practiced in Japan; Outcomes of 1300 patients
Brachytherapy 14(2)㸸111-117㸪2015
Impact factor 2.76
Satoh T, Dokiya T, Yamanaka H, Saito S, Ishiyama H, Itami J, Shibuya H, Nakano T,
Shigematsu N, Aoki M, Egawa S, Hashimoto M, Nishimura T, Yorozu A
Postmortem radiation safety and issues pertaining to permanent prostate seed
implantation in Japan
Brachytherapy 14(2)㸸136-141㸪2015
Impact factor 2.76
Saito S
Is focal prostate therapy just psychotherapy? Surveillance versus focal therapy: Pros
and cons
Focal therapy of prostate cancer.㸸19-25㸪2015
ᩧ⸨ྐ㑻ࠊ▮ᮌᗣேࠊすᒣᚭࠊ୰ᮧ᠇ࠊ㟷ᮌၨ௓ࠊᐊᝆ௓ࠊᑠὠ඙୍㑻ࠊⓑ▼ᝆࠊᡞ▮࿴ோࠊ
ⴙ⠜᠇,
๓❧⭢⒴ᒁᡤ⒪ἲࡢ㛗ᮇᡂ⦼ࠊᨺᑕ⥺἞⒪ࠊBrachytherapy㸦ᑠ⥺※⒪ἲ㸧
Japanese J Endourology 28(2)㸸207-214㸪2015
Ohashi T, Yorozu A, Saito S, Tanaka N, Katayama N, Kojima S, Maruo S, Kikuchi T,
Dokiya T, Fukushima M, Yamanaka H
Urinary and rectal toxicity profiles after permanent iodine-125 implant
brachytherapy
in
Japanese
men:
Nationwide
J-POPS
multi-institutional
prospective cohort study.
Int J Radiation Oncol Biol Phys 93(1)㸸141-149㸪2015
impact factor 2.466
Hotta K, Katsuki S, Ohata K, Abe T, Endo M, Shimatani M, Nagaya T, Kusaka T,
Matsuda T, Uraoka T, Yamaguchi Y, Murakami Y, Saito Y
Efficacy and safety of endoscopic interventions using the short double-balloon
endoscope in patients after incomplete colonoscopy.
Dig Endosc 27㸸95-8㸪2015
impact factor 2.058
― 106 ―
Uraoka T, Tanaka S, Oka S, Matsuda T, Saito Y, Moriyama T, Higashi R, Matsumoto T
Feasibility of a novel extra-wide-angle-view colonoscope: a clinical study.
Endoscopy 47㸸444-8㸪2015
impact factor 5.053
Uraoka T, Higashi R, Horii J, Harada K, Hori K, Okada H, Mizuno M, Tomoda J, MD,
Ohara N, Tanaka T, MD, Chiu HM, Yahagi N, Yamamoto K
Prospective evaluation of endoscopic criteria characteristic of sessile serrated
adenoma/polyps
J Gastroentrol 50㸸555-63㸪2015
impact factor 4.523
Pioche M, Rivory J, Aguero-Garcete G, Guillaud O, O'Brien M, Lafon C, Reversat N,
Uraoka T, Yahagi N, Ponchon T
New isolated bovine colon model dedicated to colonic ESD hands-on training:
development and first evaluation
Surg Endosc 29㸸3209-15㸪2015
impact factor 3.256
Oka S, Tamai N, Ikematsu H, Kawamura T, Sawaya M, Takeuchi Y, Uraoka T,
Moriyama T, Kawano H, Matsuda T
Improved visibility of colorectal flat tumors using image-enhanced endoscopy
Dig Endosc 27(1)㸸35-9㸪2015
impact factor 2.058
Goto O, Fujimoto A, Shimoda M, Ochiai Y, Matsuda T, Takeuchi H, Kawakubo H,
Maehata T, Uraoka T, Kameyama K, Kitagawa Y, Yahagi N
Estimation of subepithelial lateral extent in submucosal early gastric cancer:
retrospective histological analysis
Gastric Cancer 18㸸810-6㸪2015
impact factor 3.719
Goto O, Takeuchi H, Kawakubo H, Matsuda S, Kato F, Sasaki M, Fujimoto A, Ochiai Y,
Horii J, Uraoka T, Kitagawa Y, Yahagi N
Feasibility of non-exposed endoscopic wall-inversion surgery with sentinel node
basin dissection as a new surgical method for early gastric cancer: a porcine
survival study
Gastric Cancer 18㸸440-5㸪2015
impact factor 3.719
― 107 ―
Uraoka T, Ochiai Y, Fujimoto A, Goto O, Kawahara Y, Kobayashi N, Kanai T,
Matsuda S, Kitagawa Y, Yahagi N
A novel fully synthetic and self-assembled peptide solution for endoscopic
submucosal dissectionɔinduced ulcer in the stomach
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
Schölvinck DW, Goto O, Seldenrijk CA, Bisschops R, Horii J, Ochiai Y, Schoon EJ,
Schenk BE, Uraoka T, van Oijen MG, Bergman JJ, Yahagi N, Weusten BL
Detection of palisade vessels as a landmark for Barrett's esophagus in a Western
population
J Gastroenterol 2015 [Epub ahead of print]
impact factor 4.523
Yoshioka T, Nishida T, Tsujii M, Kato M, Hayashi Y, Komori M, Yoshihara H,
Nakamura T, Egawa S, Yoshio T, Yamada T, Yabuta T, Yamamoto K, Kinoshita K,
Kawai N, Ogiyama H, Nishihara A, Michida T, Iijima H, Shintani A, Takehara T
Renal dysfunction is an independent risk factor for bleeding after gastric ESD
Endosc Int Open 3㸸E39-45㸪2015
impact factor not yet assigned
Tsujii Y, Kato M, Inoue T, Yoshii S, Nagai K, Fujinaga T, Maekawa A, Hayashi Y,
Akasaka T, Shinzaki S, Watabe K, Nishida T, Iijima H, Tsujii M, Takehara T
Integrated diagnostic strategy for the invasion depth of early gastric cancer by
conventional endoscopy and EUS
Gastrointest Endosc 82㸸452-9㸪2015
impact factor 5.369
Tsujii Y, Nishida T, Nishiyama O, Yamamoto K, Kawai N, Yamaguchi S, Yamada T,
Yoshio T, Kitamura S, Nakamura T, Nishihara A, Ogiyama H, Nakahara M, Komori M,
Kato M, Hayashi Y, Shinzaki S, Iijima H, Michida T, Tsujii M, Takehara T
Clinical outcomes of endoscopic submucosal dissection for superficial esophageal
neoplasms: a multicenter retrospective cohort study
Endoscopy 47㸸775-83㸪2015
impact factor 5.053
― 108 ―
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E,
Inoue T, Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S,
Watabe K, Nishida T, Iijima H, Takehara T
The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined
with chemotherapy to target colon cancer stem-like cells
Int J Oncol 46㸸1551-9 㸪2015
impact factor 3.025
Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K,
Tsujii M, Takehara T, Mori M, Doki Y, Nakajima K
Gastric endoscopic submucosal dissection under steady pressure automatically
controlled endoscopy (SPACE); a multicenter randomized preclinical trial
Surg Endosc 29㸸2748-55㸪2015
impact factor 3.256
Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T,
Yamamoto S, Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S,
Inoue T, Shinzaki S, Watabe K, Nishida T, Iijima H, Takehara T
5̻FU resistance abrogates the amplified cytotoxic effects induced by inhibiting
checkpoint kinase 1 in p53̻mutated colon cancer cells
Int J Oncol 46㸸63-70㸪2015
impact factor 3.025
Kato M, Nishida T, Hamasaki T, Kawai N, Yoshio T, Egawa S, Yamamoto K,
Ogiyama H, Komori M, Nakahara M, Yabuta T, Nishihara A, Hayashi Y, Yamada T,
Takehara T
Outcomes of ESD for patients with early gastric cancer and comorbid liver
cirrhosis: a propensity score analysis
Surg Endosc 29㸸1560-6㸪2015
impact factor 3.256
Yoshii S, Kato M, Honma K, Fujinaga T, Tsujii Y, Maekawa A, Inoue T, Hayashi Y,
Akasaka T, Shinzaki S, Nishida T, Iijima H, Tsujii M, Morii E, Takehara T
Esophageal adenocarcinoma with white opaque substance observed by magnifying
endoscopy with narrow band imaging
Dig Endosc 27㸸392-6㸪2015
impact factor 2.058
― 109 ―
Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, Suganuma H,
Nishizaki Y
Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male
subjects
World J Gastroenterol 21㸸12457–67㸪2015
impact factor 2.369
Kikuchi M, Horie Y, Ebinuma H, Taniki N, Nakamoto N, Kanai T
Alcoholic Liver Cirrhosis and Significant Risk Factors for the Development of
Alcohol-related Hepatocellular Carcinoma-Japan
Jpn. J.Alcohol & Drug Dependence 50㸸222-34㸪2015
impact factor not yet assigned.
Nishizawa T, Uraoka T, Ochiai Y, Suzuki H, Goto O, Fujimoto A, Maehata T, Kanai T,
Yahagi N
The "two-sword fencing" technique in endoscopic submucosal dissection
Clin Endosc 48㸸85-620㸪2015
impact factor 5.369
Ikehara H, Saito Y, Uraoka T, Matsuda T, Miwa H
Specimen retrieval method using a sliding overtube for large colorectal neoplasm
following endoscopic submucosal dissection
Endoscopy 47(1)㸸E168-9㸪2015
Nishizawa T, Uraoka T, Suzuki H, Goto O, Ochiai Y, Fujimoto A, Maehata T, Kanai T,
Yahagi N
New endoscopic suturing method: slip knot clip suturing
Gastrointest Endosc 82㸸570-1㸪2015
impact factor 5.369
Tsujii Y, Kato M, Shinzaki S, Takigawa A, Hayashi Y, Nishida T, Iijima H, Tsujii M,
Takehara T
Polyglycolic acid sheets for repair of refractory esophageal fistula
Endoscopy 47(1)㸸E39-40㸪2015
impact factor 5.053
Matsui S, Uraoka T, Hasegawa H, Kitagawa Y
A case of asymptomatic incidental live anisakid worm infestation on a large rectal
polyp
BMJ Case Report 2015㸸9㸪2015
impact factor not yet assigned.
― 110 ―
Seishima, Uraoka T, Hasegawa H, Okabayashi K, Tsuruta M, Hayashi Y, Kitagawa Y
Colon cancer arising from a sessile serrated adenoma/polyp detected on positron
emission tomography/computed tomography
Gastrointest Endosc 82㸸570-1㸪2015
impact factor 5.369
Goto O, Takeuchi H, Kawakubo H, Sasaki M, Matsuda T, Matsuda S, Kigasawa Y,
Kadota Y, Fujimoto A, Ochiai Y, Horii J, Uraoka T, Kitagawa Y, Yahagi N
First case of non-exposed endoscopic wallinversion surgery with sentinel node basindissection for early gastric cancer
Gastric Cancer 18㸸434-9㸪2015
impact factor 3.719
Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M
A case of gastric adenocarcinoma of fundic gland type resected by combination of
laparoscopic and endoscopic approaches to neoplasia with non-exposure technique
(CLEAN-NET)
Clin J Gastroenterol 8㸸393-9㸪2015
impact factor not yet assigned.
Takatori Y, Kato M, Sakaguchi E, Banno S, Abe K, Takada Y, Hirata T, Wada M,
Kinoshita S, Takabayashi K, Kikuchi M, Kikuchi M, Fujiyama Y, Uraoka T
A case of extramedullary involvement of acute monocytic leukemia that presented
as obstructive jaundice
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M
Large muscle layer defect of stomach caused by ESD closed by using the endoloopclips technique
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
Yamaguchi T, Inoue T, Nishida T, Kato M, Hayashi Y, Tsujii Y, Maekawa A, Kawai S,
Fujinaga T, Araki M, Nagai K, Yoshii S, Hiyama S, Shinzaki S, Iijima H, Tsujii M,
Takehara T
Localized gastric amyloidosis mimicking a submucosal tumor-like gastric cancer
Gastrointest Endosc 82(1)㸸175-7㸪2015.7
impact factor 5.369
― 111 ―
Makino Y, Miyazaki M, Shigekawa M, Ezaki H, Sakamori R, Yakushijin T, Ohkawa K,
Kato M, Akasaka T, Shinzaki S, Nishida T, Miyake Y, Hama N, Nagano H, Honma K,
Morii E, Wakasa K, Hikita H, Tatsumi T, Iijima H, Hiramatsu N, Tsujii M, Takehara T
Solitary fibrous tumor of the liver from development to resection
Intern Med 54㸸765-70㸪2015
impact factor 0.904
ᩧ⸨⿱㍜, ᒸ ᚿ㑻, ⏣୰ಙ἞, ᩪ⸨ ㇏, ụᯇᘯᮁ, ஬༑ᔒṇᗈ, ࿴⏣⚈ᇛ, ᕤ⸨㐍ⱥ, ᑠ
ᯘΎ඾, ஭ୖ㞝ᚿ, ᾆᒸಇኵ, 㣤 ᾈᗣ, ᒣ㔝Ὀ✑, 㭯⏣ ಟ, Ọ⏣ಙ஧, ⶶཎ᫭୍, ᒣཱྀ
⿱୍㑻, బ㔝 ᑀ, ᶔ⏣༤ྐ, ᇼᯇ㧗༤, ᩪ⸨ᙲ୍, ୖ㔝⚽ᶞ, ▼㯮ࡵࡄࡳ, ▼ᕝ⚽ᶞ, ࿡ᒸ
ὒ୍, ኱಴ᗣ⏨, ⸨┒Ꮥ༤, Ώ㑓⪽᫂, ᮡཎ೺୍
ෆど㙾᦬㝖ᚋ኱⭠ T1(SM)⒴ࡢ㌿⛣࣭෌Ⓨ࡟㛵ࡍࡿከ᪋タඹྠ◊✲ ኱⭠⒴◊✲఍
ࣉࣟࢪ࢙ࢡࢺ◊✲ࡢ⤖ᯝ࠿ࡽ
⫶࡜⭠ 50(4)㸸448-56㸪2015
Mori N, Kagawa N, Higuchi A, Aoki Y, Ohkusu
Sepsis due to a novel urease-positive Helicobacter species in a young man
J Clin Microbiol. 53(7)㸸378-380㸪2015
IF 3.993
Mori N, Yoshizawa S, Saga T, Ishii Y, Murakami H, Iwatani M, Collins AD, Riley TV,
Tateda K
Incorrect diagnosis of Clostridium difficile infection in a university hospital in Japan
J Infect Chemother 21(10)㸸718-722㸪2015
IF 1.486
Mori N, Aoki Y
Clinical characteristics and risk factors for community-acquired Clostridium
difficile infection: A retrospective, case-control study in a tertiary hospital in Japan
J Infect Chemother 21(12)㸸864-867㸪2015
IF 1.486
Asakura T, Ito T, Souma T, Mori N
Postsystemic encephalopathy without liver cirrhosis masquerading as depression
Intern Med 54(13)㸸1619-22㸪2015
IF 0.904
― 112 ―
Asakura T, Mori N
Roving eye movements in a patient with hypoglycemic coma
Clin Case Reports 3㸸335-336㸪2015
⣽ᑿဏᏊࠊ᳃ఙ᫭ࠊᯇᾆ཭୍ࠊ᳃┤ᕭࠊᒣ⏣ᜨ㔛ዉࠊᖹᒣ⨾࿴ࠊ⸨ᮏ࿴ᚿࠊᑠᒣ⏣ྜྷᏕ
๻⑕ᆺ A ⩌ ǃ ⁐㐃⳦ឤᰁ⑕ࢆ࿊ࡋࡓ⫵⅖ࡢ୍౛
᪥ᮏෆ⛉Ꮫ఍㞧ㄅ 104(12)㸸2556-2562ࠊ 2015
㓇஭ ㅬ, ኱ᶫ 㟹, ᒣᓮ ᝴௓, ᩪ⸨ ᙲಙ, ᯇΎ ❧, ኱㇂ 㝯ಇ, ᭹㒊 ྜྷᡂ, 㛛ᯇ ㈼, 㩾ῲ Ύே, ᐑᇛ ┒῟, ⏣୰ ோⱥ, ┦ᕝ ཌ
PD࣭HD ే⏝⒪ἲ࡟࠾ࡅࡿデ⒪ሗ㓘ᨵᐃᚋࡢືྥ࡜ࡑࡢᒎᮃ࡟ࡘ࠸࡚
⭈࡜㏱ᯒ 79(ู෉⭡⭷㏱ᯒ 2015)㸸95-96ࠊ2015.10
㹙⥲ㄝ㹛
ᑿ⸨ㄔྖ
࣐ࣝࢳࣔࣅࢹ࢕ࢸ࢕࡟࠾ࡅࡿ἞⒪ඃඛ㡰఩࡜೔⌮ⓗࢪ࣐ࣞࣥࠕ࠶ࡕࡽࢆ❧࡚ࢀࡤ,ࡇࡕ
ࡽࡀ❧ࡓࡎࠖ࠿ࡽࡢྜពᙧᡂ እ᮶࡛ࠕ」ᩘࡢ⑌ᝈࠖࢆࡶࡘᝈ⪅ࢆデࡿ࣐ࣝࢳࣔࣅࢹ࢕
ࢸ࢕ࡢ᫬௦ࡢࣉࣛ࢖࣐࣭ࣜࢣ࢔
⥲ྜデ⒪ 25(12)㸸1131-1134㸪2015.12
Ụཱྀ◊஧㸪ᑠ಴ᮁᏊ㸪ᑿ⸨ㄔྖ㸪ᖹ㔝࿴ᜨ㸪஧ࣀᆏಖ႐
⤊ᮎᮇ་⒪ ࿧྾ჾ⑌ᝈࡢ⤊ᮎᮇ་⒪ࢣ࢔ࡢㄢ㢟
࿧྾ 34(8)㸸748-757㸪2015.8
୕ᾆஂᖾ, ᮌ⃝⩏அ, ᑿ⸨ㄔྖ, ᑠ㔝ἑ⁠, ΎỈဴ㑻, ᵽཱྀ⠊㞝, 㧗᲍᪩ⱑ, すᕝ‶๎,
ཎ⏣ᩔ, 㫽⩚◊஧
ࠕே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ་⒪࡟࠿࠿ࡿ┦ㄯဨࡢ◊ಟࣉࣟࢢ࣒ࣛࠖࡢ᭷⏝ᛶ
㔞ⓗ㉁ⓗ࣑ࢵࢡࢫἲ
᪥ᮏ⪁ᖺ་Ꮫ఍㞧ㄅ 52㸸77㸪2015.5
ᑿ⸨ㄔྖ
࢚ࣥࢻ࣭࢜ࣈ࣭ࣛ࢖ࣇࢣ࢔࡟࠾ࡅࡿពᛮỴᐃࡢ⪃࠼᪉ ⌧ሙ࡛ά⏝࡛ࡁࡿ
ពᛮỴᐃᨭ᥼ࡢࢃࡊ
⦆࿴ࢣ࢔ 25(3)㸸207-212㸪2015.5
ᑿ⸨ㄔྖ
ࠕࡸࡵࡽࢀ࡞࠸࠿ࡽࡣࡌࡵ࡞࠸ࠖ࠿ࡽᢤࡅฟࡑ࠺
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.1.21
― 113 ―
ᑿ⸨ㄔྖ
㸦⫗యⓗ࡟㸧③࠸ᛮ࠸ࢆࡋ࡚཯┬ࡋࡲࡋࡓ
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.3.13
ᑿ⸨ㄔྖ
ࠕᏳᚰ࣭Ᏻ඲ࠖࡣࡢࢁ࠸ࡢ࿚ᩥ
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.4.24
ᑿ⸨ㄔྖ
⮬Ꮿ࡛ࡢ┳ྲྀࡾࢆ࠶ࡲࡾၨⵚࡋ࡞࠸࡛࡯ࡋ࠸
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.7.24
ᑿ⸨ㄔྖ
ࠕ೔⌮ࢧ࣏࣮ࢺࢳ࣮࣒ࠖࡣࡌࡵࡲࡋࡓ
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.9.8
ᑿ⸨ㄔྖ
ࠕ࠾௵ࡏࡋࡲࡍࠖࡣࢲ࣓ฟࡋࡢྜᅗ
᪥⤒࣓ࢹ࢕࢝ࣝ࢜ࣥࣛ࢖ࣥ㸸2015.11.18
Uraoka T, Hosoe N, Yahagi N
Colonoscopy: is it as effective as an advanced diagnostic tool for colorectal cancer
screening?
Expert Rev Gastroenterol Hepatol 9㸸129-32㸪2015
impact factor 2.417
Moriyama T, Uraoka T, Esaki M, Matsumoto T
Advanced technology for the improvement of adenoma and polyp detection during
colonoscopy
Dig Endosc 27(1)㸸40-4㸪2015
Impact factor 2.06
Kato M
Diagnosis and therapies for gastric non-invasive neoplasia
World J Gastroenterol 21㸸12513-8㸪2015
impact factor 2.369
― 114 ―
Nishida T, Kato M, Yoshio T, Akasaka T, Yoshioka T, Michida T, Yamamoto M,
Hayashi S, Hayashi Y, Tsujii M, Takehara T
Endoscopic submucosal dissection in early gastric cancer in elderly patients and
comorbid conditions
World J Gastrointest Endosc7㸸524-31㸪2015
impact factor not yet assigned.
Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA,
Aytaman A, Reddy KR, Chang KM
Distinct features in natural history and outcomes of acute hepatitis C
J Clin Gastroenterol 49㸸e31-40㸪2015
impact factor 3.498
㧗ᯘ 㤾, ᾆᒸಇኵ, ຍ⸨ඖᙪ, ⴠྜᗣ฼, ▮స┤ஂ
LST ࡢศ㢮࡜ࡑࡢ≉ᚩ
⮫ᗋᾘ໬ჾෆ⛉ 30(9)㸸1149-54ࠊ2015
ⴠྜᗣ฼,㣬ᮏဴර,ᮌୗ ⪽,┦Ⰻㄔ஧,๓⏿ᛅ㍤,⸨ᮏឡ,ᚋ⸨ಟ,୰ᮧ⌮ᜨᏊ,す⃝ಇᏹ,
ᾆᒸಇኵ,▮స┤ஂ
༑஧ᣦ⭠⭢⭘࣭⭢⒴ࡢ㚷ูデ᩿࡜἞⒪
ᾘ໬ჾෆど㙾 27(1)㸸133-40㸪2015
ᾆᒸಇኵ, ▮స┤ஂ
ᮍ᮶ࡢ኱⭠ෆど㙾ࣔࢲࣜࢸ࢕࣮
ᾘ໬ჾෆど㙾 27(4)㸸696-8ࠊ2015
ⴠྜᗣ฼, 㣬ᮏဴර, ┦Ⰻㄔ஧, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ୰ᮧ⌮ᜨᏊ, す⃝ಇᏹ, ᚋ⸨ ಟ,
ᾆᒸಇኵ, ▮స┤ஂ
༑஧ᣦ⭠⾲ᅾᛶ⭘⒆࡟ᑐࡍࡿෆど㙾἞⒪ࡢ᪉㔪
ᾘ໬ჾෆど㙾 27(7)㸸1095-102ࠊ2015
ⴠྜᗣ฼, ᾆᒸಇኵ, ▮స┤ஂ
ࠕ⫶࣭༑஧ᣦ⭠ࠖ࡭࠿ࡽࡎ ༑஧ᣦ⭠ ESD ࠶࡞ࡓࡣࡸࡗ࡚ࡣ࠸ࡅ࡞࠸
ᾘ໬ჾෆど㙾 27(2)㸸244-5ࠊ2015
㧗ᯘ 㤾, ᾆᒸಇኵ, ▮స┤ஂ
ࠕ኱⭠ࠖ࡭࠿ࡽࡎ ESD ඛ➃⣔࡛ࡇࢀࡣࡸࡗ࡚ࡣ࠸ࡅ࡞࠸
ᾘ໬ჾෆど㙾 27(2)㸸279-81ࠊ2015
― 115 ―
బ㔝 ᑀ, ⏣୰ಙ἞, ᕤ⸨㐍ⱥ, ᩪ⸨ᙲ୍, ᯇ⏣ᑦஂ, ࿴⏣⚈ᇛ, ⸨஭㝯ᗈ, ụᯇᘯᮁ,
ᾆᒸಇኵ, ᑠᯘ ᮃ, ୰ᮧᑦᚿ, ᇼ⏣Ḡ୍, ᇼᯇ㧗༤, ᆏᮏ┤ே, ഌ ග⩏, 㭯⏣ ಟ,
Ἑ㔝ᘯᚿ, ᶔ⏣༤ྐ, ➉ෆὒྖ, ⏫⏣ᾈஂ, ᪥ୗ฼ᗈ, ྜྷ⏣┤ஂ, ᖹ⏣୍㑻, ᑎ஭ Ẏ,
ᒣ㔝Ὀ✑, 㔠Ꮚ࿴ᘯ, ୰ᓥ ೺, ᆏᮏ ⌶, ᒣཱྀ⿱୍㑻, ⋢஭ᑦே, ୸ᒣᑦᏊ, ᯘ ዉ㑣,
ᒸ ᚿ㑻, ᒾ㤋ᓠ㞝, ▼ᕝ⚽ᶞ, ᮧୖ⩏Ꮥ, ྜྷ⏣ⱱ᫛, ᩪ⸨ ㇏, The Japan NBI Expert
Team(JNET)
The Japan NBI Expert Team(JNET)኱⭠ᣑ኱ Narrow Band Imaging(NBI)ศ㢮
Intestine 19(1)㸸5-13ࠊ2015
ᾆᒸಇኵ
࠙ෆ⛉⑌ᝈࡢデ᩿ᇶ‽࣭⑓ᆺศ㢮࣭㔜⑕ᗘࠚ(➨ 2 ❶) ᾘ໬ჾ ኱⭠⭘⒆
ෆ⛉ 115(6)㸸960-4ࠊ2015
ᾆᒸಇኵ, ᮌୗ ⪽, 㧗ᯘ 㤾, ຍ⸨ ඖᙪ, ⳥ụ ┿኱
Cold Polypectomy ࡢ᭷⏝ᛶ࡜ࢥࢶ
ᾘ໬ჾෆど㙾 27(10)㸸1718-23ࠊ2015
๓⏿ᛅ㍤, 㣬ᮏဴර, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, ୰ᮧ⌮ᜨᏊ, す⃝ಇᏹ, ᚋ⸨ ಟ, ᾆᒸಇኵ, ▮స┤ஂ
ᾘ໬⟶⒴ࡢ἞⒪᪉㔪ࡢ❧࡚᪉࣭㐍ࡵ᪉ ኱⭠⒴ࡢෆど㙾἞⒪㐺ᛂ࡜ࠊእ⛉࣭⸆≀⒪ἲ
㛤ጞ࣭⛣⾜ࡢࢱ࢖࣑ࣥࢢ
᪥ᮏࢥࣥࣆ࣮ࣗࢱእ⛉Ꮫ఍ㄅ 17(2)㸸91-100ࠊ2015
ᾆᒸಇኵ, ᯇ⏣ᑦஂ
ᑠᆺ኱⭠࣏࣮ࣜࣉ࡟ᑐࡍࡿ Cold polypectomy
Gastroenterological Endoscopy 57(9)㸸2370-8ࠊ2015
㧘ᯘ 㤾, ᾆᒸಇኵ, ᮌୗ⪽, ຍ⸨ඖᙪ, ▮స┤ஂ
ESD ⏝ඛ➃࢔ࢱࢵࢳ࣓ࣥࢺࢆ౑࠸ࡇ࡞ࡍࢥࢶ
ᾘ໬ჾෆど㙾 27(8)㸸1308-12ࠊ2015
ຍ⸨ඖᙪ, ㉥ᆏᬛྐ, ஭ୖᣅஓ, 㔜ᕝ ⛱
࠙⾑౽ࢆࡳࡓࡽࠚ ⾑౽ࢆࡁࡓࡍ⑌ᝈࡢ≉ᚩ࣭ෆど㙾ീ࡜ᑐฎἲ ⭠⟶Ꮚᐑෆ⭷⑕
ᾘ໬ჾෆど㙾 27(10)㸸1691-1695ࠊ2015.11.16
⸨ᇛගᘯ, ஭ཱྀᖿᓫ, ゅᔱ┤⨾, ຍ⸨ඖᙪ, ᆏ⏣㈨ᑦ, ᕸ⿄ᒇ ಟ, ∦ᒸᖿ⤫, ᓥᒸಇ἞, ▮స┤ஂ, ⸨ᮏ୍┾, ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍
㠀㟼⬦⒗ᛶୖ㒊ᾘ໬⟶ฟ⾑࡟࠾ࡅࡿෆど㙾デ⒪࢞࢖ࢻࣛ࢖ࣥ
Gastroenterological Endoscopy 57(8)㸸1648-66ࠊ2015
― 116 ―
ຍ⸨ඖᙪ, 㜿㒊ᆂ୍㑻, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾,
⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
State of the art ኱⭠ ESD ࢆࡵࡄࡗ࡚ ኱⭠ ESD ࡢࢹࣂ࢖ࢫࡢ≉ᚩ࣭౑࠸ศࡅ
኱⭠ࡀࢇ perspective 2㸸2188-4560ࠊ2015
⳥ụ┿኱, ᱵ⏣⍠⨾Ꮚ, 㭯㇂ᗣኴ, ሷ⃝ᏹ࿴, ᯇᔱᡂᚿ, 㜿㒊ᆂ୍ᮁ, ⳥ụ⨾✑, 㧗ᶫṇᙪ,
ᒣᓊ⏤ᖾ, すᓮὈᘯ, ᇼỤ⩏๎, 㔠஭㝯඾
㠀౵くⓗ⫢⬡⫫ ᐃ Controlled Attenuation Parameter (CAP)࡟ࡼࡿ࢔ࣝࢥ࣮ࣝᛶ
⫢㞀ᐖᝈ⪅ࡢ㚷ู
᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㞧ㄅ 50㸸235-47ࠊ2015
ᇼỤ⩏๎, ᾏ⪁἟ᾈ฼, ⳥ụ┿኱, ୰ᮏఙᏹ, 㔠஭㝯඾
ᮏ㑥࡟࠾ࡅࡿ࢔ࣝࢥ࣮ࣝᛶ⫢◳ኚࡢᐇែ
⫢⮚ 56㸸366-8ࠊ2015
❑⃝㝧Ꮚࠊ㧘ᯘ㤾ࠊ㧗ྲྀ♸సࠊ㜿㒊ᆂ୍ᮁࠊ㧗⏣♸᫂ࠊᖹ⏣ဴࠊబ⸨㐨Ꮚࠊᡂ℩ᬛᗣࠊ
ຍ⸨ඖᙪࠊ⳥ụ┿኱ࠊ⸨ᒣὒ୍ࠊᩧ⸨ඃᏊࠊᒣᮏ⣪つᏊࠊᮧ⏣᭷ஓࠊ๓ᓥ᪂ྐࠊ㧗ᶫṇᙪࠊ
బ⸨཭㝯ࠊᾆᒸಇኵ
ከ⮚ჾ㌿⛣ࢆ᮶ࡋࡓ㣗㐨ཎⓎ↓Ⰽ⣲ᛶᝏᛶ㯮Ⰽ⭘ࡢ 1
Progress of Digestive Endoscopy 87(1)㸸96-7ࠊ2015
బ⸨㐨Ꮚࠊ㧘ᯘ㤾ࠊ㜿㒊ᆂ୍ᮁࠊ㧗⏣♸᫂ࠊᖹ⏣ဴࠊ㧗ྲྀ♸సࠊᡂ℩ᬛᗣࠊຍ⸨ඖᙪࠊ
⸨ᒣὒ୍ࠊ㧗ᶫṇᙪࠊຓ⏣ⵇࠊⓑ▼῟୍ࠊᾆᒸಇኵ
⚄⤒ෆศἪ⣽⬊࡬ࡢศ໬ࢆ♧ࡍపศ໬⭢⒴ᡂศࢆకࡗࡓ㝯㉳ᆺ⫶⢓⭷ෆ⒴ࡢ 1 ౛
Progress of Digestive Endoscopy 87(1)㸸124-5ࠊ2015
ᯇᮧ┿ྖ
㧗㱋⪅࢚࣐࣮ࢪ࢙ࣥࢩ࣮ࠕᩆᛴ࡟㏦ࡗࡓᚋࡢ㧗㱋⪅࣐ࢿࢪ࣓ࣥࢺɆᖐࡾࡓࡃ࡚ࡶᖐࢀ࡞
࠸
⥲ྜデ⒪ 25(5)㸸482-486ࠊ2015.5
[ⴭ᭩]
ᑿ⸨ㄔྖ
་⪅ࡢゝ࠺ࡇ࡜ࡣヰ༙ศ࡛࠸࠸
඲ 207 ࣮࣌ࢪࠊ㹎㹆㹎◊✲ᡤࠊ2015.12.3
ᑿ⸨ㄔྖ
ᬑ㏻ࡢ⤒⭠ᰤ㣴๣࡜⑓ែู⤒⭠ᰤ㣴๣࡜ච␿㈿ά⣔⤒⭠ᰤ㣴๣ࡢẚ㍑
⸆ࡢࢹࢠࣗࢫࢱࢩ࢜ࣥɆ〇⸆࣓࣮࣮࢝࡟㢗ࡽࡎ࡟⸆࡜ຮᙉࡍࡿࡓࡵ࡟Ɇࠊ
(ᒾ⏣೺ኴ㑻)ࠊ251-259ࠊ㔠ⰾᇽࠊ2015.11.20
― 117 ―
⳥ụ┿኱
⭡Ỉ
ࢪ࢙ࢿࣛࣜࢫࢺࡢࡓࡵࡢእ᮶ึ⒪࣭ฎ⨨࢞࢖ࢻࠊ་Ꮫ᭩㝔ࠊ2015
᳃ఙ᫭
㉁␲ᛂ⟅ ProпPro ෆ⛉㸸ឤᰁ⑕ 㧗⑓ཎᛶࢡࣟࢫࢺࣜࢪ࣒࣭࢘ࢹ࢕ࣇ࢕ࢩࣝ࡟ࡼࡿ
⭠⅖ࡢ἞⒪
᪥ᮏ་஦᪂ሗ㸶᭶㸳㐌ྕࠊNo.4766ࠊ2015
ᯇᮧ┿ྖࠊୖ㔝༓㭯Ꮚ
ࠕࢣ࢔ࡢ࢝ࣜࢫ࣐ࡓࡕ㸫┳ྲྀࡾࢆᨭ࠼ࡿࣉࣟࣇ࢙ࢵࢩࣙࢼࣝࠖࠊ49-86ࠊள⣖᭩ᡣࠊ
2015.3
ᮌᮧ⌶☻ࠊᯇᮧ┿ྖ
㢗ࢀࡿ୺἞་࡟࡞ࡿࡓࡵࡢ㧗㱋⪅デ⒪ࡢࢥࢶࢆྛ⛉ᑓ㛛་ࡀᩍ࠼ࡲࡍࠊ⨺ᅵ♫ࠊ2015.4
ᯇᮧ┿ྖࠊ⚟஭៞ኴ㑻ࠊᒣ⏣ᗣ௓
᪥ᮏㄒ∧࣭ᐙᗞ་⒪ࡢ㉁Ɇデ⒪ᡤ࡛౑࠺ࢶ࣮ࣝࣈࢵࢡɆࠊ࢝࢖᭩ᯘࠊ2015.4
᪥ᮏࣉࣛ࢖࣐࣭ࣜࢣ࢔㐃ྜᏛ఍࣭⩻ヂࢳ࣮࣒
ᯇᮧ┿ྖ
⏥≧⭢ᶵ⬟ஹ㐍⑕࣭పୗ⑕
࢚ࣆࢯ࣮ࢻࢆぢ㏨ࡍ࡞㸟 ᚎࠎ࡟㐍⾜ࡍࡿ⑌ᝈ࡬ࡢ㐃ᦠ࢔ࣉ࣮ࣟࢳࠊ(ෆᒣᐩኈ㞝࣭
すᮧ┿⣖)ࠊ98-102ࠊࣉ࣓ࣜࢻ♫ࠊ2015.6
[Ꮫ఍Ⓨ⾲]
ᑿ⸨ㄔྖ
ࠕࢃ࠿ࡾ࠶࠼࡞࠸ࠖ᫬௦ࡢᝈ⪅-་⒪⪅㛫ࠊከ⫋✀㛫ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ
ࠕ┳ㆤᖌࠊ⸆๣ᖌ࡜⫵ࡀࢇᑓ㛛་ᖌ࡜ࡢᑐヰ✵㛫 4㹼⌧ሙ࡛ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ㹼
➨ 56 ᅇ᪥ᮏ⫵⒴Ꮫ఍Ꮫ⾡㞟఍ࠊ⚄ዉᕝ┴ᶓ὾ᕷࠊ2015.11.27
㐲ᒣ⩏ᙪ, ᒸ⏣⨾⳯Ꮚ, Ṋ஭┿ᑑ௦, ┠㯮ᗣᖹ, Ⲩ஭᫓ዉ, ᑠᖭᩄ἞, ☾㒊㝧, ᑿ⸨ㄔྖ,
▼ᕝ࣋ࣥࢪ࣑ࣕࣥග୍
ᆅᇦ་⒪ᵓ᝿ࡢ་⒪㟂せ᥎ィࢆ฼⏝ࡋࡓ㧗ᗘᛴᛶᮇ⑓ᗋࡢ᳨ド
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍ࠊ໭ᾏ㐨ᮐᖠᕷࠊ2015.10.2-3
ᮏᕝဴ, ᑿ⸨ㄔྖ, ᐑ⏣ⱱᶞ, ྑ⏣Ύᚿ, ୰ᮧ┿₻, ⇃㇂ㅬ἞, J-PSVT ◊✲⌜
ேᕤ㛵⠇⨨᥮⾡ᚋࡢ⾑ᰦண㜵࡜ࡋ࡚ࡢᶵᲔⓗᅽ㏕ἲ࡟ࡼࡿ࣊ࣃࣜࣥ㉳ᅉᛶ⾑ᑠᯈ
ῶᑡ⑕(HIT)ࡢⓎ⑕せᅉ
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍ࠊ໭ᾏ㐨ᮐᖠᕷࠊ2015.10.2-3
― 118 ―
ᑿ⸨ㄔྖ
⮫ᗋ◊✲࡟࠾ࡅࡿ฼┈┦཯ࢆ⪃࠼ࡿ ࠕ࡛ࡁࡿࡇ࡜࠿ࡽጞࡵࡼ࠺ࠖ
Ⴀ฼௻ᴗ࡜⮫ᗋ་࣭◊✲⪅࡜ࡢ㐺ษ࡞㛵ಀసࡾ
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍ࠊ໭ᾏ㐨ᮐᖠᕷࠊ2015.10.2-3
୰ᮧ᠇ࠊ㟷ᮌၨ௓ࠊᐊᝆ௓ࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊすᒣᚭࠊᡞ▮࿴ோࠊⴙ⠜᠇ࠊᩧ⸨ྐ㑻,
๓❧⭢⒴ᐦᑒᑠ⥺※Ọஂᤄධ⒪ἲ(BT)ᚋࡢ⢭ᄞ෌Ⓨ࡟ᑐࡋ salvage BT ࢆ⾜ࡗࡓ㸯౛
➨ 127 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍Ἀ⦖ᆅ᪉఍ࠊ㑣ぞࠊ2015.1.31
Yorozu A, Eriguchi T, Saito S, Kuroiwa N, Takahashi A, Toya K, Shiraishi Y,
Nishiyama T, Yagi Y
Dose
effects
on
long-term
urinary
morbidity
after
permanent
prostate
brachytherapy with or without external beam radiotherapy in 1,300 petients
36th Annual Meeting of the American Brachytherapy Society 㸪 Orlando,USA 㸪
2015.4.9
Nakamura K, Aoki K, Yagi Y, Ozu C, Nishiyama T, Toya K, Yorozu A, Saito S
Clinical outcomes of I-125 seed implantation brachytherapy for high risk prostate
cancer
36th Annual Meeting of the American Brachytherapy Society 㸪 Orlando,USA 㸪
2015.4.9
୰ᮧ ᠇ࠊ㟷ᮌၨ௓ࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊすᒣ ᚭࠊᡞ▮࿴ோࠊⴙ ⠜᠇ࠊᩧ⸨ྐ㑻
๓❧⭢⒴ࣚ࢘⣲ 125 ᐦᑒᑠ⥺※⒪ἲᚋ PSA ୖ᪼౛࡟࠾ࡅࡿ⤒఍㝜ⓗ๓❧⭢⏕᳨
➨ 103 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍⥲఍ࠊ㔠ἑࠊ2015.4.18
▮ᮌᗣேࠊ㟷ᮌၨ௓ࠊ୹⩚┤ஓࠊ୰ᮧ᠇ࠊᑠὠ඙୍㑻ࠊすᒣᚭࠊᡞ▮࿴ோࠊⴙ⠜᠇ࠊ
ᩧ⸨ྐ㑻
๓❧⭢⒴ᐦᑒᑠ⥺※἞⒪ࡢ QOL ࡟እ↷ᑕ἞⒪ࡸෆศἪࡀཬࡰࡍᙳ㡪
➨ 103 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍⥲఍ࠊ㔠ἑࠊ2015.4.19
すᒣᚭࠊ㟷ᮌၨ௓ࠊ୹⩚┤ஓࠊ୰ᮧ᠇ࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊᩧ⸨ྐ㑻
ᙜ㝔࡟࠾ࡅࡿ㦵┙ෆ⮚ჾ⬺࡟ᑐࡍࡿ tension-free vaginal mesh (TVM) ᡭ⾡
➨ 103 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍⥲఍ࠊ㔠ἑࠊ2015.4.20
㟷ᮌၨ௓ࠊ୰ᮧ᠇ࠊᖹἑ㝧௓ࠊ୹⩚┤ஓࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊすᒣᚭࠊᩧ⸨ྐ㑻
ᙜ㝔࡟࠾ࡅࡿࣟ࣎ࢵࢺᨭ᥼ୗ᰿἞ⓗ๓❧⭢඲᦬㝖⾡ࡢᑟධ୍ᖺࡢึᮇᡂ⦼
➨ 103 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍⥲఍ࠊ㔠ἑࠊ2015.4.20
― 119 ―
Tanaka N, Yorozu A, Maruo S, Kojima S, Ohashi T, Katayama N, Saito S, Dokiya T,
Fukushima M, Yamanaka H, Fujimoto K
To predict a good candidate who undergo a permanent iodine-125 seed implantation
in respect of urinary morbidity from the results of a nationwide cohort study in
Japan
2015 American Urological Association Annual Meeting 㸪 New Orleans,USA 㸪
2015.5.19
Shiro Saito
Long term outcomes of prostate brachytherapy in Japan
2015 The first Beijing International Conference of Modern Brachytherapy㸪໭ி,
୰ᅜ㸪2015.8.21
㟷ᮌၨ௓ࠊᑠὠ඙୍㑻ࠊ୰ᮧ ᠇ࠊᐊ ᝆ௓ࠊ▮ᮌᗣேࠊすᒣ ᚭࠊᩧ⸨ྐ㑻
ࣟ࣎ࢵࢺᨭ᥼ୗ๓❧⭢඲᦬㝖⾡ࡢ⭤⬔ᒀ㐨࿀ྜ࡟࠾ࡅࡿ⦎⩦࡜ learning curve ࡢ┦㐪
➨ 80 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍ᮾ㒊⥲఍ࠊᮾிࠊ2015.9.26
ᐊᝆ௓ࠊ㟷ᮌၨ௓ࠊ୰ᮧ᠇ࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊすᒣᚭࠊᩧ⸨ྐ㑻
㔜⢏Ꮚ἞⒪ᚋ࡟ salvage ࣟ࣎ࢵࢺᨭ᥼ୗ๓❧⭢඲᦬㝖⾡ࢆ᪋⾜ࡋࡓ๓❧⭢⒴ࡢ 1 ౛
➨ 80 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍ᮾ㒊⥲఍ࠊᮾிࠊ2015.9.27
ᩧ⸨ྐ㑻ࠊすᒣᚭࠊ▮ᮌᗣேࠊ୰ᮧ᠇ࠊ㟷ᮌၨ௓ࠊᐊᝆ௓ࠊᑠὠ඙୍㑻ࠊᡞ▮࿴ோࠊⴙ⠜᠇
ᑠ⥺※⒪ἲࡢ᭷ຠᛶ࡜ࡑࢀࢆᨭ࠼ࡿᢏ࡜໶
➨ 80 ᅇ᪥ᮏἪᒀჾ⛉Ꮫ఍ᮾ㒊⥲఍ࠊᮾிࠊ2015.9.27
ⴙ⠜᠇ࠊ㯮ᒾಙᏊࠊ㧗ᶫⲁࠊබ⏣㱟୍ࠊ㧗ᕝె᫂ࠊᩧ⸨ྐ㑻ࠊすᒣᚭࠊ▮ᮌᗣே
๓❧⭢⒴ࡢ↷ᑕᚋ෌Ⓨ࡟ᑐࡍࡿᩆ῭ෆศἪ⒪ἲࡢ௓ධ࡜ணᚋ
➨ 53 ᅇ᪥ᮏ⒴἞⒪Ꮫ఍Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.10.29
Ἀཎᏹ἞ࠊ௰㔝ṇ༤ࠊⴙ⠜᠇ࠊ⏣୰ᐉ㐨ࠊྂ㈡ᐶྐࠊᩧ⸨ྐ㑻ࠊ୸ᑿఙ୍㑻ࠊ⚟ᓥṇ๎ࠊ
ᅵჾᒇ༟ᚿࠊᒣ୰ⱥኖ
࣍ࣝࣔࣥࢼ࢖࣮ࣈᐦᑒᑠ⥺※἞⒪ᝈ⪅࡟࠾ࡅࡿ⏨ᛶᶵ⬟ホ౯
➨ 53 ᅇ᪥ᮏ⒴἞⒪Ꮫ఍Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.10.29
▮ᮌᗣேࠊ㟷ᮌၨ௓ࠊᐊᝆ௓ࠊすᒣᚭࠊᡞ▮࿴ோࠊⴙ⠜᠇ࠊᩧ⸨ྐ㑻
๓❧⭢⒴ᐦᑒᑠ⥺※἞⒪ᚋ࡟࠾ࡅࡿ PSA ෌Ⓨ⑕౛ࡢ᳨ウ
➨ 53 ᅇ᪥ᮏ⒴἞⒪Ꮫ఍Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.10.29
― 120 ―
ᩧ⸨ྐ㑻ࠊ▮ᮌᗣேࠊすᒣᚭࠊ୰ᮧ᠇ࠊ㟷ᮌၨ௓ࠊᐊᝆ௓ࠊᑠὠ඙୍㑻ࠊⓑ▼ᝆࠊᡞ▮࿴ோࠊ
ⴙ⠜᠇
ప⥺㔞⋡ᑠ⥺※⒪ἲࡢᮏ㑥㛗ᮇᡂ⦼
᪥ᮏἪᒀჾ⭘⒆Ꮫ఍➨ 1 ᅇᏛ⾡㞟఍ࠊி㒔ࠊ2015.10.31
Shiro Saito
Recent aspects of permanent prostate brachytherapy
The 15th National Conference of Radioactive Seed Brachytherapyࠊ⁚ᕞ,୰ᅜࠊ
2015.11.07,
㟷ᮌၨ௓ࠊᐊ ᝆ௓ࠊ୰ᮧ ᠇ࠊ▮ᮌᗣேࠊᑠὠ඙୍㑻ࠊすᒣ ᚭࠊᩧ⸨ྐ㑻
ഃ᪉࢔ࣉ࣮ࣟࢳ࡟ࡼࡿ⭤⬔๓❧⭢㞳᩿ࡢ᭷⏝ᛶࡢ᳨ウ
➨ 29 ᅇ᪥ᮏἪᒀჾෆど㙾Ꮫ఍⥲఍ࠊᮾிࠊ2015.11.20
Pioche M, Rivory J, Aguero G, Guillaud O, O'Brien M, Uraoka T, Yahagi N, Ponchon T
New isolated bovine colon model dedicated to colonic ESD hands-on training:
development and first evaluation
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
Fujimoto A, Ochiai Y, Goto O, Nishizawa T, Nakamura R, Maehata T, Kinoshita S,
Sagara S, Uraoka T, Yahagi N
Efficacy of a 2% rebamipide solution as a novel submucosal injection agent for
gastric endoscopic submucosal dissection
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
Uraoka T, Fujimoto A, Ochiai Y, Goto O, Kawahara Y, Hori K, Masayuki S, Yahagi Y
High pressure carbon dioxide submucosal injection in endoscopic submucosal
dissection
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
Takatori Y, Kato M, Suzuki M, Abe K, Hirata T, Takada Y, Naruse T, Takabayashi K,
Kikuchi M, Fujiyama Y, Takahashi M, Uraoka T
History of gastro-duodenal ulcer as an independent predictor for requirement of
endoscopic intervention for non-variceral upper gastrointestinal bleeding
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
Sato M, Kato M, Suzuki M, Abe K, Takada Y, Hirata T, Takatori Y, Naruse T,
Takabayashi K, Kikuchi M, Fujiyama Y, Takahashi M, Uraoka T
Should all patients with colonic diverticular hemorrhage undergo urgent
colonoscopy?
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
― 121 ―
Uraoka T, Tanaka S, Saito Y, Matsumoto T, Saito S, Oka S, Matsuda T, Moriyama T,
Ogata H, Yahagi N, Tajiri H, Ishikawa H
Diagnostic value of extra-wide-angle-view colonoscope in the aAdenoma detection: a
multicenter randomized controlled trial.
Digestive Disease Week 2015㸪Washington D.C./USA㸪2015.5
Uraoka T, Fujimoto A, Ochiai Y, Goto O, Maehata T, Nishizawa T, Kawahara Y, Hori K,
Kato M, Shimoda M, Yahagi N
A novel high-pressure carbon dioxide submucosal injection technique in endoscopic
submucosal dissection
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Kato M, Sakaguchi E, Abe K, Takada Y, Hirata T, Banno S, Wada M, Takatori T,
Kinoshita S, Kikuchi H, Takabayashi K, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M,
Ohishi T, Uraoka T
Screening colonoscopy for subjects older than 85 years old
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Wada M, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y, Hirata T,
Takatori Y, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M,
Uraoka T
The history of colonic diverticular hemorrhage and colonoscopic hemostasis are
independent predictors for reccurent hemorrhage
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Hirata T, Uraoka T, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y,
Takatori Y, Wada M, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y,
Suzuki M, Ohishi T
Endoscopic management for sigmoid volvulus : Should we perform endoscopic
detorsion all cases?
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Takatori Y, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y, Hirata T,
Wada M, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M,
Uraoka T
History of gastro-duodenal ulcer is an independent predictor for requirement of
endoscopic hemostasis for non-variceral upper gastrointestinal bleeding
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
― 122 ―
Maehata T, Uraoka T, Goto O, Akimoto T, Sagara S, Ochiai Y, Fujimoto A,
Nishizawa T, Yahagi N
Varidity of endoscopic submucosal dissection for colorectal T1 (submucosal invation)
cancer.
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Ochiai Y, Akimoto T, Sagara S, Maehata T, Fujimoto A, Nakamura R, Nishizawa T,
Goto O, Uraoka T, Yahagi N
Clinical outcome of endoscopic submucosal dissection for superficial duodenal
neoplasm in 60 lesions
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Pioche M, Rivory J, Nishizawa T, Uraoka T, Lienhart I, Ponchon T, Yahagi N
Randomized comparative evaluation of an ESD self-learning software in France and
Japan
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Fujimoto A, Goto O, Akimoto T, Maehata T, Ochiai Y, Nishizawa T, Nakamura R,
Sagara S, Akimoto T, Shimoda M, Uraoka T, Yahagi N
Evaluation of the speed and quality of gastric ulcer healing after ESD using 2%
rebamipide solution as a novel submucosal injection material
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Kato M, Nishida T, Yamamoto T, Kitamura S, Yamada T, Egawa S, Komori M,
Kawai N, Nishihara A, Nakanishi F, Nakahara M, Ogiyama H, Mukai A, Hayashi Y,
Tsujii M, Takehara T
Severe atrophic gastritis is a significant risk factor of metachronous multiple gastric
cancer: A Multicentre Retrospective Cohort Study by the Osaka Gut Forum
United Enropean Gastroenterology 2015㸪Barcelona/Spain㸪2015.10
Masahiro Kikuchi, Rumiko Umeda, Kota Tsuruya, Hirokazu Shiozawa, Miho Kikuchi,
Masahiko Takahashi,Yoshinori Horie, Yasuhiro Nishizaki
Diagnostic accuracy for non-alcoholic fatty liver disease (NAFLD) with controlled
attenuation parameter (CAP) measured by transient elastography
The 66th American Association for the Study of the Liver㸪San Francisco(USA)㸪
2015.11.17
― 123 ―
Yasuhiro Nishizaki,Chizumi Yamada, Noriaki Kishimoto, Nobushige Yukumatsu,
Hirokazu Shiozawa, Norihito Watanabe, Rumiko Umeda, Masahiro Kikuchi,
Takanori Kanai, Naoaki Tshii
Ferritin derived oxidative stress is a risk for liver damage even within reference
range in male
The 10th World Congress for Microcirculation㸪Kyoto㸪2015.9.25
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ, 㧗ᯘ㤾, ⳥ụ┿኱, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
⫶༑஧ᣦ⭠₽⒆ࡢ᪤ ࡣୖ㒊ᾘ໬⟶ฟ⾑ᝈ⪅࡟࠾࠸࡚ෆど㙾ⓗṆ⾑⾡ࡢ⊂❧ࡋࡓ༴㝤
ᅉᏊ࡛࠶ࡿ
➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.2
ᚋ⸨ ಟ, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ୗ⏣ᑗஅ, ᯇ⏣ 㐩㞝, బࠎᮌ ᇶ, ⴠྜᗣ฼, ᇼ஭ᇛ୍ᮁ,
ᾆᒸಇኵ, ᕝஂಖ༤ᩥ, ➉ෆ⿱ஓ, ໭ᕝ㞝ග, ▮స┤ஂ
SM ⫶⒴࡟ᑐࡍࡿෆど㙾ⓗ඲ᒙษ㝖⾡࡟࠾ࡅࡿ㐺ษ࡞ษ㞳᩿➃㊥㞳ࡢ᳨ウ
➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.2
ᇼ ᆂ௓, ᾆᒸಇኵ, ཎ⏣㤾ኴ, ᮾ ⋹἞, Ἑཎ⚈ᮁ, ᒸ⏣⿱அ, ▮స┤ஂ ᒣᮏ࿴⚽
࣮ࣛࢽࣥࢢ࣮࢝ࣈ࡟ᛂࡌࡓ኱⭠ ESD ᅔ㞴⑕౛ࡢண ᅉᏊ࡟㛵ࡍࡿ᳨ウ
➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.2
㣬ᮏဴර, ᚋ⸨ ಟ, ᮌୗ ⪽, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ,
ᾆᒸಇኵ, ⥴᪉ᬕᙪ, ᆏᮏ㛗㐓, ▮స┤ஂ.
ᙜ㝔࡛῝㐩ᗘデ᩿ࡀᅔ㞴࡛࠶ࡗࡓ᪩ᮇ⫶⒴ෆど㙾἞⒪⑕౛ࡢ᳨ウ
➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.2
๓⏿ᛅ㍤, ᚋ⸨ ಟ, ➉ෆ⿱ஓ, 㣬ᮏဴර, ᮌୗ ⪽, ┦Ⰻㄔ஧, す⃝ಇᏹ, ⸨ᮏ ឡ,
ⴠྜᗣ฼, ᾆᒸಇኵ, ➉ෆ⿱ஓ, ໭ᕝ㞝ග, ▮స┤ஂ
NEWS ࡜ࢭࣥࢳࢿࣝࣜࣥࣃ⠇ࢼࣅࢤ࣮ࢩࣙࣥᡭ⾡ࡢ⼥ྜ࡟ࡼࡿ᪂ࡋ࠸⫶⒴⦰ ᑠᡭ⾡
➨ 87 ᅇ᪥ᮏ⫶⒴Ꮫ఍Ꮫ⾡㞟఍ࠊᗈᓥࠊ2015 3
ᾆᒸಇኵ, ຍ⸨ඖᙪ, ▮స┤ஂ
኱⭠ ESD ἞⒪ᅔ㞴౛࡟ᑐࡍࡿ࢔ࣉ࣮ࣟࢳ ɆDual knifeɆ
➨ 101 ᅇ᪥ᮏᾘ໬ჾᏛ఍Ꮫ⾡㞟఍ࠊᐑᇛ┴௝ྎᕷࠊ2015.4
ຍ⸨ඖᙪ, ኱▼ᓫ, ᾆᒸಇኵ
↓⑕≧ࡢ 85 ṓ௨ୖࡢ㉸㧗㱋⪅࡟኱⭠ෆど㙾᳨ᰝࡣᚲせ࠿㸽
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
― 124 ―
⸨ᮏឡ, ᾆᒸಇኵ, ▮స┤ஂ
Dual Red Imaging ࡢ⌧≧࡜ᒎᮃ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ⴠྜᗣ฼, ᾆᒸಇኵ, ▮స┤ஂ
┤⭠⫠㛛㒊⭘⒆࡟࠾ࡅࡿෆど㙾἞⒪ᅔ㞴⑓ኚ࡟ᑐࡍࡿ ESD
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ᾆᒸಇኵ, ᚋ⸨ಟ, ▮స┤ஂ
⫶ ESD ᚋ₽⒆࡟ᑐࡍࡿ᪂つ⮬ᕫ⤌⧊໬࣌ࣉࢳࢻỈ⁐ᾮࡢ⮫ᗋᛂ⏝ࡢྍ⬟ᛶ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
๓⏿ᛅ㍤, ᾆᒸಇኵ, 㣬ᮏဴර, ᮌୗ⪽, ┦Ⰻㄔ஧, బࠎᮌᇶ, す⃝ಇᏹ, ᚋ⸨ಟ, ⸨ᮏឡ,
ⴠྜᗣ฼, ▮స┤ஂ
᪩ᮇ኱⭠⒴ pT1(SM)⑕౛࡟ᑐࡍࡿ ESD ࡢጇᙜᛶ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
┦Ⰻㄔ஧, ᚋ⸨ಟ, 㣬ᮏဴර, ᮌୗ⪽, ⸨ᮏឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, す⃝ಇᏹ, ᾆᒸಇኵ,
⥴᪉ᬕᙪ, ▮స┤ஂ
ᙜ⛉࡟࠾ࡅࡿࢹ࢟ࢧ࣓ࢹࢺ࣑ࢪࣥ㙠㟼ୗ㧗㞴ᗘ ESD ࡢᐇ㝿
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ,
㧗ᯘ㤾, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
⫶༑஧ᣦ⭠₽⒆ࡢ᪤ ࡣୖ㒊ᾘ໬⟶ฟ⾑ᝈ⪅࡟࠾ࡅࡿෆど㙾ⓗṆ⾑⾡ࡢせྰ࡟ᑐࡍࡿ
⊂❧ࡋࡓண ᅉᏊ࡛࠶ࡿ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ᮌୗ ⪽, す⃝ಇᏹ, 㣬ᮏဴර, ┦Ⰻㄔ஧, ᚋ⸨ಟ, ๓⏿ᛅ㍤, ⸨ᮏឡ, ⴠྜᗣ฼,
୰ᮧ⌮ᜨᏊ, ᾆᒸಇኵ, ▮స┤ஂ
༑஧ᣦ⭠⭘⒆࡟ᑐࡍࡿෆど㙾἞⒪࡜἞⒪ᡓ␎ࡢ⌧≧
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
బ⸨㐨Ꮚ, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ဴ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ,
㧗ᯘ㤾, ⳥ụ┿኱, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
኱⭠᠁ᐊฟ⾑඲౛࡟ෆど㙾ⓗṆ⾑⾡ࢆ᪋⾜ࡍ࡭ࡁ࠿㸽㹼෌ฟ⾑ࣜࢫࢡᅉᏊ࡟㛵ࡍࡿᚋ
᪉どⓗࢥ࣮࣍ࢺ◊✲㹼
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
― 125 ―
㣬ᮏဴර, ᚋ⸨ಟ, ᮌୗ⪽, ┦Ⰻㄔ஧, ⸨ᮏឡ, ⴠྜᗣ฼, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ,
᳜ᮌಙỤ, ᾆᒸಇኵ, ㎮ཱྀ⠜ᚿ, ୕Ꮿ୍ᫀ, ᆏᮏ㛗㐓, ▮స┤ஂ
H.pylori 㝖⳦ᚋ⫶⒴࠾ࡼࡧ⫼ᬒ⢓⭷࡟⏕ࡌࡿ⤌⧊Ꮫⓗኚ໬࡜ෆど㙾デ᩿ࡢ᳨ウ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ᴿᾈ⾜, ཎ⏣㤾ኴ, ᾆᒸಇኵ, 㧗ᔱᚿಖ, ஭ཱྀಇ༤, ➉஭኱௓, ᮡཎ㞝⟇, ༙஭᫂᪥㤶,
㧗ཎᨻᏹ, ᑠᯘἋ௦, 㧗ᶫ⣴┿, 㰺⸨ಇ௓, ᇼ஭ᇛ୍ᮁ, ᮾ⋹἞, ᖹᒸబつᏊ, ᒸ⏣⿱அ,
ᒣᮏ࿴⚽
ෆど㙾ⓗ⢓⭷ୗᒙ๤㞳⾡(ESD)ࡀ᪋⾜ࡉࢀࡓ኱⭠ T1(SM)⒴ࡢ἞⒪ᡂ⦼࡜ணᚋࡢ᳨ウ
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ᾆᒸಇኵ, ▮స┤ஂ
኱⭠⒴ࢫࢡ࣮ࣜࢽࣥࢢ࡟࠾ࡅࡿ㏆ᮍ᮶ࡢ኱⭠ෆど㙾ࣔࢲࣜࢸ࢕࣮
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
㧗ᯘ 㤾, 㜿㒊ᆂ୍㑻, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, ຍ⸨ඖᙪ,
⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ
኱⭠ ESD ࡟࠾ࡅࡿᡭᢏⓗᅔ㞴⑕౛ࠊ⾡ᚋ⊃✽⑕౛࡟ᑐࡍࡿ᳨ウ
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
⸨ᮏ ឡ,ⴠྜ ᗣ฼,ᚋ⸨
ᮌୗ
ಟ, ๓⏿ᛅ㍤, ᇼ஭ᇛ୍ᮁ, 㧗ᯘ 㤾, 㣬ᮏဴර, ┦Ⰻㄔ஧,
⪽, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ᾆᒸಇኵ, ▮స ┤ஂ
Dual Red Imaging ࡢ⌧≧࡜ᒎᮃ
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
ᖹ⏣ ဴ, ຍ⸨ ඖᙪ, 㜿㒊ᆂ୍ᮁ
㧗⏣♸᫂, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾,
⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, 㧗ᶫṇᙪ, ᾆᒸಇኵ
S ≧⤖⭠᤬㌿⑕࡟ᑐࡍࡿෆど㙾ⓗᩚ᚟ࡢព⩏࡟ࡘ࠸࡚ࡢ᳨ウ
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
ⴠྜᗣ฼, 㣬ᮏဴර, ᮌୗ ⪽, ┦Ⰻㄔ஧, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ᚋ⸨ ಟ, ୰ᮧ⌮ᜨᏊ,
す⃝ಇᏹ, ᾆᒸಇኵ, ▮స┤ஂ
ᙜ㒊㛛࡟࠾ࡅࡿ༑஧ᣦ⭠ ESD ࡢᏳ඲ᛶ࠾ࡼࡧ᭷ຠᛶࡢホ౯
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
❑⃝㝧Ꮚ, 㧗ᯘ 㤾, 㧗ྲྀ♸స, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨ 㐨Ꮚ, ᡂ℩ᬛᗣ,
ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, 㰺⸨ඃᏊ, ᒣᮏ⣪つᏊ, ᮧ⏣᭷ஓ, ๓ᓥ᪂ྐ, 㧗ᶫṇᙪ,
బ⸨཭㝯, ᾆᒸಇኵ
ከ⮚ჾ㌿⛣ࢆ᮶ࡋࡓ㣗㐨ཎⓎ↓Ⰽ⣲ᛶᝏᛶ㯮Ⰽ⭘ࡢ 1 ౛
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
― 126 ―
㣬ᮏဴර, ᚋ⸨ ಟ, 㭯⏣ 㞞ኈ, ᮌୗ ⪽, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤,
す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ᾆᒸಇኵ, ⥴᪉ᬕᙪ, டᒣ㤶⧊, ▮స ┤ஂ
ESD ࡛᏶඲ษ㝖ࡉࢀࡓ SM ῝㒊ᾐ₶⒴ࡀ▷ᮇ㛫࡛ᒁᡤ෌Ⓨࡋࡓ 1 ౛
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
┦Ⰻㄔ஧, ᚋ⸨ ಟ, 㣬ᮏဴර, ᮌୗ ⪽, ⸨ᮏ ឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, す⃝ಇᏹ,
ᾆᒸಇኵ, ▮స┤ஂ
ESD ἞⒪㏵୰ࡼࡾࢹࢡࢫ࣓ࢹࢺ࣑ࢪࣥࢆᑟධࡋⰋዲ࡞㙠㟼ࡀᚓࡽࢀࡓ 2 ⑕౛
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.6
㧗⏣♸᫂, ຍ⸨ඖᙪ, 㜿㒊ᆂ୍㑻, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾,
⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, 㧗ᶫṇᙪ, ᾆᒸಇኵ
ᑠ⭠࢔ࢽࢧ࢟ࢫ⑕ࡢ⮫ᗋീ࡟ࡘ࠸࡚ࡢ᳨ウ
Japan Digestive Disease Weekࠊරᗜ┴⚄ᡞᕷࠊ2015.10
⳥ụ┿኱, すᓮὈᘯ, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾, ຍ⸨ඖᙪ, ⳥ụ⨾✑, ⸨ᒣὒ୍, ᾆᒸಇኵ,
㧗ᶫṇᙪ, ᒣᓊ⏤ᖾ, ᇼỤ⩏๎, ຍ⸨┾୕, 㔠஭㝯඾
CAP(Controlled Attenuation Parameter)┦㛵࣐࣮࣮࢝ࡢ᳨ウ࡜㸪࢔ࣝࢥ࣮ࣝᛶ⫢㞀
ᐖ࣭㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈࡢ㚷ู
Japan Digestive Disease Weekࠊරᗜ┴⚄ᡞᕷࠊ2015.10
⸨ᮏ ឡ, ୗ⏣ᑗஅ, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, ᚋ⸨ ಟ, ┦Ⰻㄔ஧,
ᮌୗ ⪽, 㣬ᮏဴර, ᾆᒸಇኵ, ▮స┤ஂ
඲ᒙษ㝖᫬௦ࡢ᪩ᮇ⫶⒴⠊ᅖデ᩿ - ഃ᪉ఙᒎ㊥㞳࡟㛵ࡍࡿ⑓⌮Ꮫⓗ᳨ウ
Japan Digestive Disease Weekࠊරᗜ┴⚄ᡞᕷࠊ2015.10
ຍ⸨ඖᙪ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, ⳥ụᘯே,
㧗ᯘ 㤾, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ኱▼ ᓫ, ᾆᒸಇኵ
㉸㧗㱋⪅࡟ᑐࡍࡿ኱⭠ෆど㙾᳨ᰝࡢ㐺ᛂ࡟ࡘ࠸࡚ࡢ᳨ウ
Japan Digestive Disease Weekࠊරᗜ┴⚄ᡞᕷࠊ2015.10
┦Ⰻㄔ஧, ᚋ⸨ ಟ, 㣬ᮏဴර, ⸨ᮏ ឡ, ๓⏿ᛅ㍤, ⴠྜᗣ฼, す⃝ಇᏹ, ᾆᒸಇኵ,
▮స┤ஂ
኱⭠ ESD ᅔ㞴⑕౛࡟࠾ࡅࡿࣂ࣮ࣝࣥෆど㙾ࡢ᭷⏝ᛶࡢ᳨ウ
Japan Digestive Disease Weekࠊරᗜ┴⚄ᡞᕷࠊ2015.10
㜿㒊ᆂ୍ᮁ, ⳥ụ┿኱, ᮌୗ ⪽, 㧗ᯘ 㤾, ຍ⸨ඖᙪ, ⳥ụ⨾✑, ⸨ᒣὒ୍, ᾆᒸಇኵ
࢔ࣝࢥ࣮ࣝᛶ៏ᛶ⮅⅖࡟ࡼࡿ⮅ᛶ⭡Ỉ࡟ᑐࡋ࡚࢜ࢡࢺࣞ࢜ࢳࢻ㓑㓟ሷࡀዌຌࡋࡓ 1 ౛
➨ 50 ᅇ࢔ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍ࠊරᗜ┴⚄ᡞᕷࠊ2015.10
― 127 ―
㧘ᯘ 㤾ࠊᆏཱྀᜨ⨾ࠊ㜿㒊ᆂ୍ᮁࠊ㧗⏣♸᫂ࠊᖹ⏣ ဴࠊక㔝⦾㞝ࠊ࿴⏣㐨Ꮚࠊ㧗ྲྀ♸సࠊ
▼ᶫᗣ๎ࠊᮌୗ ⪽ࠊ⳥ụ⨾✑ࠊຍ⸨ඖᙪࠊ⳥ụ┿኱ࠊ⸨ᒣὒ୍ࠊᾆᒸಇኵ
☜ᐇ࡞ Cold snare polypectomy ࢆᛕ㢌࡟⨨࠸ࡓࢫࢿ࢔ࡢ㑅ᢥ
᪥ᮏ኱⭠᳨ᰝᏛ఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.11
ᖹ⏣ ဴ, ⳥ụ┿኱, ᆏཱྀ᝴ᐇ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗ྲྀ♸స,
ᮌୗ ⪽, 㧘ᯘ 㤾, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ
ᙜ㝔࡟࠾ࡅࡿ⫢ᛶ⭡Ỉ࡟ᑐࡍࡿࢺࣝࣂࣉࢱࣥᑟධ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
㜿㒊ᆂ୍㑻, ⳥ụ┿኱, ᆏཱྀ᝴ᐇ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗ྲྀ♸స,
ᮌୗ ⪽, 㧘ᯘ 㤾, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ
ERCP(ෆど㙾ⓗ㏫⾜ᛶ⮅⫹⟶㐀ᙳ)࡟࠾ࡅࡿ⮅⟶ࢫࢸࣥࢺࡢ᭷⏝ᛶ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
క㔝⦾㞝, 㧘ᯘ 㤾, ᆏཱྀ᝴ᐇ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, 㧗ྲྀ♸స, ᮌୗ ⪽, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ⓑ▼῟୍, ᾆᒸಇኵ
ᙜ㝔࡛ෆど㙾ⓗ⢓⭷ୗᒙ๤㞳⾡ࢆ᪋⾜ࡋࡓ Barrett ⭢⒴ࡢ᳨ウ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
ຍ⸨ඖᙪ, ☾㒊 㝧, ᆏཱྀ᝴ᐇ, 㧘ᯘ 㤾, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗ྲྀ♸స,ᮌୗ ⪽, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ
ୖ㒊ᾘ໬⟶⭘⒆࡟ᑐࡍࡿ⭡⭍㙾ෆど㙾ྜྠᡭ⾡(LECS)࡟ࡼࡿప౵く἞⒪
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ, 㧗ᯘ㤾, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
ESD ࡢᬑཬࡣෆど㙾ⓗṆ⾑⾡࡟࡞࡟ࢆࡶࡓࡽࡋࡓ࠿
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
క㔝⦾㞝, 㧘ᯘ 㤾, ᆏཱྀᜨ⨾, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, 㧗ྲྀ♸స, ▼ᶫᗣ๎,ᮌୗ ⪽, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ
NBI ే⏝ᣑ኱ほᐹ࠾ࡼࡧ㉸㡢Ἴෆど㙾ࡀ῝㐩ᗘデ᩿࡟᭷⏝࡛࠶ࡗࡓ 0-IIc㸩Is ᆺ㣗㐨⒴
ࡢ୍౛
᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔༓௦⏣༊ࠊ2015.12
㧗⏣♸᫂, ຍ⸨ඖᙪ, ᆏཱྀ᝴⨾, 㜿㒊ᆂ୍ᮁ, ᖹ⏣ ဴ, 㧗ྲྀ♸స, క㔝⦾㞝, ࿴⏣㐨Ꮚ, ᮌୗ ⪽, 㧗ᯘ 㤾, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, ᾆᒸಇኵ
⭢⒴ᡂศࡀΰᅾࡋࡓ㣗㐨⫶᥋ྜ㒊ཎⓎ⚄⤒ෆศἪ⒴ࡢ 1 ๗᳨౛
᪥ᮏᾘ໬ჾ⑓Ꮫ఍➨ 337 ᅇ㛵ᮾᨭ㒊౛఍ࠊᮾி༓௦⏣༊ࠊ2015.12
― 128 ―
ఀᮾఙ๛, ┦㤿ᓫᏹ, ጒᑿ⪽⨾, ☾㒊⩏᠇, ᆏཱྀ᝴⨾, ⳥ụ┿኱
ྤ⾑࡛Ⓨ⑕ࡋࡓ Budd-Chiari ⑕ೃ⩌ࡢ୍౛
ᮾி࢔ࣥࢠ࣭࢜㹇㹔㹐఍ࠊ ᮾிࠊ2015.12.10
᪂ᓥ኱㍜, ᐑཎ᫂㔛, ᶲ ᭸⨾, 㛗㇂㒊ࡺࡾ, 㜿㒊ᆂ୍ᮁ, ⳥ụ⨾✑, ⳥ụ┿኱
ᙜ㝔࡟࠾ࡅࡿ⫢⮚⑓ᩍᐊࡢྲྀࡾ⤌ࡳ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ୡ⏣㇂༊ࠊ2015.12
ᇼỤ⩏๎㸪ᾏ⪁἟ᾈ฼㸪୰ᮏఙᏹ㸪⳥ụ┿኱㸪㔠஭㝯඾
ᮏ㑥࡟࠾ࡅࡿ࢔ࣝࢥ࣮ࣝᛶ⫢⅖ࡢᐇែɆ2013 ᖺᗘࡢ⑕౛ࡢゎᯒɆ
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
ᱵ⏣⍠⨾Ꮚ㸪ሷ⃝ᏹ࿴㸪⳥ụ┿኱㸪すᓮὈᘯ
࢔ࣝࢥ࣮ࣝᛶ⫢◳ኚࡢ㞴἞ᛶ⭡Ỉ࡟ᑐࡋ⭡Ỉ✸่࡜ CART㸦Cell-free and
Concentrated AscitesReinfusion Therapy㸧ࢆే⏝ࡋⰋዲ࡞⤖ᯝࢆᚓࡓ 2 ⑕౛
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
⳥ụ┿኱㸪ᇼỤ⩏๎㸪෠⏣ㅬ࿃㸪ᱵ⏣⍠⨾Ꮚ㸪㭯㇂ᗣኴ㸪ሷ⃝ᏹ࿴㸪すᓮὈᘯ㸪⳥ụ⨾✑㸪
㧗ᶫṇᙪ㸪㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘኱ࡢ㐃㛵ᛶ
࡟㛵ࡍࡿ᳨ウ
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
ᇼỤ⩏๎㸪⳥ụ┿኱㸪㔠஭㝯඾
ෆ⛉་ࡢ❧ሙ࠿ࡽࡢ࢔ࣝࢥ࣮ࣝ἞⒪࡟࠾ࡅࡿ་⒪㐃ᦠ࡜ᚰ⌮♫఍ⓗ἞⒪
➨ 50 ᅇ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㸪රᗜ௳⚄ᡞᕷ㸪2015.10
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ෠⏣ㅬ࿃ࠊᱵ⏣⍠⨾Ꮚࠊ㭯㇂ᗣኴࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊ
⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊ㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘ࡢ┦㛵ᛶ
➨ 50 ᅇ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㸪රᗜ௳⚄ᡞᕷ㸪2015.10
⳥ụ┿኱ࠊすᓮὈᘯࠊᮌୗ⪽ࠊᡂ℩ᬛᗣࠊ㧗ᯘ㤾ࠊຍ⸨ඖᙪࠊ⳥ụ⨾✑ࠊ⸨ᒣὒ୍ࠊ
ᾆᒸಇኵࠊ㧗ᶫṇᙪࠊᒣᓊ⏤ᖾࠊᇼỤ⩏๎ࠊຍ⸨┾୕ࠊ㔠஭㝯඾
CAP(Controlled Attenuation Parameter)┦㛵࣐࣮࣮࢝ࡢ᳨ウ࡜࢔ࣝࢥ࣮ࣝᛶ⫢㞀
ᐖ࣭㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈࡢ㚷ู
➨ 23 ᅇ Japan Digestive Disease Weekࠊᮾிࠊ2015.10
― 129 ―
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊ
ᒣᓊ⏤ᖾࠊຍ⸨┾୕ࠊ㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘ࡢ㛵ಀ
➨ 22 ᅇ᪥ᮏ㛛⬦ᅽஹ㐍⑕Ꮫ఍ せᮃ₇㢟ࠊᶓ὾ࠊ2015.9.11
⳥ụ┿኱, 㧗ᯇ༓⧊, 㕥ᮌᰤ㔛Ꮚ, ㏆⸨┿⃈, ᒣ⏣༓✚,ᓊᮏ᠇᫂,ᱵ⏣⍠⨾Ꮚ ,㭯㇂ᗣኴ,
ሷ⃝ᏹ࿴, すᓮὈᘯ, ⳥ụ⨾✑, 㧗ᶫṇᙪ,㔠஭㝯඾
ே㛫ࢻࢵࢡ࡛ࡢ⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡࣭⬡⫫⫢㝧ᛶ⋡ࡢゎᯒ࡜ࠊFibroscan
ࢹ࣮ࢱࡢ᳨ウ
➨㸰ᅇ⫢⮚࡜⢾ᒀ⑓ࠊ௦ㅰ◊✲఍ࠊᒣཱྀ┴ୗ㛵ᕷࠊ2015.5.23
ᓊᮏ᠇᫂ࠊᒣ⏣༓✚ࠊ➉⏣㯞⨾ࠊᑿᙧ⌔ᜨࠊ㯮⏣ᜨ⨾Ꮚࠊ⳥ụ┿኱ࠊ㇂㔝㝯୕㑻ࠊஂಖ᫂ࠊ
▼஭┤᫂ࠊすᓮὈᘯ
HDL ࢥࣞࢫࢸ࣮ࣟࣝளศ⏬࡜⬡㉁࣭࣏ࣜ⺮ⓑ௦ㅰࣉࣟࣇ࢓࢖ࣝࡢ㛵㐃ᛶ
➨ 43 ᅇ᪥ᮏ⥲ྜ೺デᏛ఍ࠊᐩᒣ┴ᐩᒣᕷࠊ2015.2.20
⳥ụ┿኱ࠊᒣ⏣༓✚ࠊᓊᮏ᠇᫂ࠊᱵ⏣⍠⨾Ꮚࠊ㭯㇂ᗣኴࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯ
⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡ࠊ⬡⫫⫢㝧ᛶ⋡ࡢኚ㑄
➨ 43 ᅇ᪥ᮏ⥲ྜ೺デᏛ఍ࠊᐩᒣ┴ᐩᒣᕷࠊ2015.2.20
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊ
ᒣᓊ⏤ᖾࠊຍ⸨┾୕ࠊ㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖࡢᛴᛶᮇ࡟࠾ࡅࡿ Fibroscan ⫢◳ᗘࡢព⩏
➨ 3㸲ᅇ࢔ࣝࢥ࣮ࣝ་Ꮫ⏕≀Ꮫ◊✲఍ࠊ୕㔜ࠊ2015.1.24
⳥ụ┿኱ࠊ㧗ᯇ༓⧊ࠊ㕥ᮌᰤ㔛Ꮚࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊ
㏆⸨┿⃈ࠊᒣ⏣༓✚ࠊすᓮὈᘯ
ே㛫ࢻࢵࢡ࡛ࡢ⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡࣭⬡⫫⫢㝧ᛶ⋡ࡢゎᯒ࡜ࠊ
Fibroscan ࢹ࣮ࢱࡢ᳨ウ
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
ᒣ⏣༓✚ࠊ㏆⸨┿⃈ࠊ⳥ụ┿኱ࠊᓊᮏ᠇᫂ࠊ㛗஭㝧Ꮚࠊᰘ⏣೺㞝ࠊ௒すつࠊ➟ཱྀ㝯㔜ࠊ
▼஭┤᫂ࠊすᓮὈᘯ
೺ᖖே࡟࠾ࡅࡿ⫢ᶵ⬟࡜⾑୰࢔࣑ࣀ㓟⃰ᗘ࡜ࡢ㛵㐃
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
㏆⸨┿⃈ࠊᒣ⏣༓✚ࠊඖᮧஂಙࠊᓊᮏ᠇᫂ࠊすᓮὈᘯࠊ⳥ụ┿኱ࠊⓑ▼ග୍ࠊ
ᮌᮧᏲḟࠊ㇏⏣㞞ኵࠊ῝ᕝ㞞ྐ
ప࢚ࢿࣝࢠ࣮㣗࡜ SGLT-2 㜼ᐖ⸆ే⏝࡟ࡼࡾ 1 ࠿᭶࡛ 10 ਻ࡢῶ㔞࡟ᡂຌࡋࡓ 2 ᆺ⢾
ᒀ⑓ࡢ 1 ౛
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
― 130 ―
ᾆᒸಇኵ, 㮚ᑿಇ㐩, ▮స┤ஂ
᪩ᮇ༑஧ᣦ⭠⒴࡟ᑐࡍࡿෆど㙾ษ㝖⾡࠾ࡼࡧእ⛉ᡭ⾡ࡢ㐺ᛂ 㸫 ከ᪋タ㐳ཬⓗ᳨ウ
ᅜ❧ࡀࢇ◊✲ࢭࣥࢱ࣮◊✲㛤Ⓨ㈝࣭ᩪ⸨ ㇏ ⌜㸦25-A-12㸧
ࠕෆど㙾἞⒪ࡢᡂ⦼ࠊணᚋࠊ
ࣂ࢖࢜ࣂࣥࢡ➼ࡢ᝟ሗࢆ⤫ྜࡍࡿ⥲ྜⓗ◊✲ᇶ┙ࡢᩚഛࠖ
ࠊᮾி㒔୰ኸ༊ࠊ2015.9
Mori.N, Aoki Y
Clinical characterization and risk factors of community-acquired Clostiridium
difficile infection in a tertiary hospital in Japan
25th European Congress of Clinical Microbiology and Infectious Diseases 㸪
Copenhagen/Denmark㸪2015.4.26
᳃ఙ᫭ࠊᵽཱྀᬗᏊࠊ▼ᚿ⣫ࠊ㟷ᮌὈᏊ
ࢹࣥࢢ⇕ࡢᅜෆឤᰁࡀ␲ࢃࢀࡿ⑕౛࡟㛵ࢃࡿ⾜ᨻㄪᰝせ௳࡟ヱᙜࡋࡓ㸶⑕౛ࡢ⑕౛㞟
✚◊✲
➨ 89 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍⥲఍Ꮫ⾡ㅮ₇఍ࠊி㒔ࠊ2015.4.16
᳃ఙ᫭ࠊᮌᮧ᭷᥹ࠊ㟷ᮌὈᏊ
ࣜࢿࢰࣜࢻᢞ୚୰࡟ங㓟࢔ࢩࢻ࣮ࢩࢫࢆ࿊ࡋࡓ⑕౛ࡢ᳨ウ㸸⑕౛ࢩ࣮ࣜࢬ◊✲
➨ 64 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍ᮾ᪥ᮏᆅ᪉఍ࠊ➨ 62 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍ᮾ᪥ᮏᨭ㒊ᆅ᪉఍ࠊ
ᮐᖠࠊ2015.10.22
኱ᒇᐶ❶ࠊ᳃ఙ᫭ࠊ㟷ᮌὈᏊ
࣓ࢺࣟࢽࢲࢰ࣮ࣝ㛗ᮇ౑⏝୰࡟࣓ࢺࣟࢽࢲࢰ࣮ࣝㄏⓎᛶ⬻⑕ࢆࡁࡓࡋࡓ㸯౛
➨ 64 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍ᮾ᪥ᮏᆅ᪉఍ࠊ➨ 62 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍ᮾ᪥ᮏᨭ㒊ᆅ᪉఍ࠊ
ᮐᖠࠊ2015.10.22
⸨ᮏ࿴ᚿࠊ᳃ఙ᫭ࠊ⯞ὠὒᖹࠊᑠᒣ⏣ྜྷᏕ
៏ᛶ࿧྾ჾ⑌ᝈ࡟ྜేࡋࡓ㞴἞ᛶ⥳⮋⳦ឤᰁ⑕࡟ᑐࡋࠊࢺࣈ࣐ࣛ࢖ࢩࣥ྾ධ⏝㔞ࡼࡾ
἞⒪ࡢᡂྰࡀ␗࡞ࡗࡓ㸯౛
➨ 64 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍ᮾ᪥ᮏᆅ᪉఍ࠊ➨ 62 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍ᮾ᪥ᮏᨭ㒊ᆅ᪉఍ࠊ
ᮐᖠࠊ2015.10.22
ἨᩔᏊࠊ㉺㒊㯞཭Ꮚࠊᖹ஭ᝆ୍㑻ࠊᯘဴᮁࠊ᳃ఙ᫭
⥳⮋⳦ឤᰁ⑕Ⓨ⑕ண ᅉᏊࡢᵓ⠏࡜ጇᙜᛶࡢ᳨ド
➨ 64 ᅇ᪥ᮏឤᰁ⑕Ꮫ఍ᮾ᪥ᮏᆅ᪉఍ࠊ➨ 62 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍ᮾ᪥ᮏᨭ㒊ᆅ᪉఍ࠊ
ᮐᖠࠊ2015.10.22
㣤ᑿ⨾࿴ࠊ᳃ఙ᫭ࠊᒣᮏᗣ༤ࠊ⣽ᑿဏᏊࠊᒣ⏣ᜨ㔛ዉࠊ⸨ᮏ࿴ᚿࠊ⯞ὠὒᖹࠊ㔛ぢⰋ㍜ࠊ
ⱝᮌ⨾బࠊᑿ௰❶⏨ࠊᑠᒣ⏣ྜྷᏕ
పᐜ㔞ࢺࣈ࣐ࣛ࢖ࢩࣥ྾ධࡀ཯᚟ᛶ⥳⮋⳦ᛶ⫵⅖ࡢ෌Ⓨண㜵࡟᭷⏝࡛࠶ࡗࡓ୍౛
➨ 217 ᅇ᪥ᮏ࿧྾ჾᏛ఍㛵ᮾᆅ᪉఍ࠊᮾிࠊ2015.11.21
― 131 ―
Ⳣཎ᱈Ꮚࠊ㤶ᕝᡂேࠊᵽཱྀᬗᏊࠊゅ⏣ⴌࠊ᳃ఙ᫭ࠊ㟷ᮌὈᏊ
⾑ᾮᇵ㣴࠿ࡽ Streptobacillus moniliformis ࡀศ㞳ࡉࢀࡓ㸯౛
➨㸰㸵ᅇ᪥ᮏ⮫ᗋᚤ⏕≀Ꮫ఍⥲఍ࠊ௝ྎࠊ2016.1.30
᳃ఙ᫭
Antimicrobial Stewardship ࢆ㐍ࡵࡿࡓࡵࡢࠕቨࠖࢆ࡝࠺஌ࡾ㉺࠼ࡿ࠿ࠊࠕASP ࢆ㐍ࡵ
ࡿࡓࡵࡢ࣐ࣥࣃ࣮࣡ࢆ࠸࠿࡟ࡋ࡚☜ಖࡍࡿ࠿ࠖ
➨ 63 ᅇ᪥ᮏ໬Ꮫ⒪ἲᏛ఍⥲఍ࠊᮾிࠊ2015.6.6
ᯇᮧ┿ྖࠊᑠᓮ┿つᏊࠊ⚄㇂ㅍࠊእᒣᏛࠊᮾᑦᘯࠊᑿ⸨ㄔྖࠊ࿴ᗙ୍ᘯ
㉁ᣦᶆࢆ⏝࠸ࡓᆅᇦデ⒪ᡤ࡟࠾ࡅࡿࣉࣛ࢖࣐ࣜࢣ࢔ࡢホ౯࡜ࡑࡢㄢ㢟
➨ 10 ᅇ་⒪ࡢ㉁࣭Ᏻ඲Ꮫ఍ࠊᮾி㒔Ụᮾ༊ࠊ2015.11.22
᫓⏣῟ᚿ, ᑠᓥឡ, 㣤ᒸ⥴⨾ ௚
஦౛ࡢ」㞧ࡉࡣከ⫋✀࡟࠾ࡅࡿྜពᙧᡂ࡜┠ᶆタᐃ࡟࡝ࡢࡼ࠺࡞ᙳ㡪ࢆ୚࠼ࡿࡢ࠿?
➨ 47 ᅇ᪥ᮏ་Ꮫᩍ⫱Ꮫ఍኱఍ࠊ᪂₲ᕷ 2015.7.24
኱ᔱ ὒభ, ᰩཎ ໏, ᐑୗ ࿴Ꮨ, ᑠᯘ బ⣖Ꮚ, ᶓ⏣ ೺୍, ᇛ ⌮⤮, 㛛ᯇ ㈼,
Ṋ⏣ ᙬ஀, ᑠ㯮 ⲡኴ, ᐑᔱ ဴ, டᒣ 㤶⧊, ఀ⸨ ⿱
」ᩘࡢ⭘⒆ࡀ࠶ࡿ PA ࡟࠾ࡅࡿ㉸㑅ᢥⓗ๪⭈㟼⬦ࢧࣥࣉࣜࣥࢢࡢព⩏
➨ 25 ᅇ⮫ᗋෆศἪ௦ㅰ Updateࠊᮾி༓௦⏣༊ࠊ2015.11.27-28
㛫℩ ⱱᶞ, ᒸ⏣ ᩫᏊ, 㧗ᶫ 㒓, ᰩᒣ 㝧Ꮚ, すཎ భ୍, ኱㭯 ὒ, 㛛ᯇ ㈼
ࠕ᪂㣗ḧ୙᣺ᑐ⟇㣗(᪂ࡑࡵ࠸ࡼࡋࡢ㣗)ࠖᑟධ࡟ྥࡅ࡚ 1 ᖺ㛫ࡢ NST ௓ධ⑕౛ࢆ᣺
ࡾ㏉ࡗ࡚
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍ࠊᮐᖠࠊ2015.10.2-3
ᮾ㑚 ⨾㔛, 㛛ᯇ ㈼, ⏣ᓥ ᜨⳀ㤶, 㧗ᶫ ฼ዉ, ᳃ ┤ᕫ, ᒾᓮ ᫀᶞ, ᵽᒣ ⯙㞷,
Ᏻᐩ ኱♸, ᯇᾆ ཭୍
ᡂேࡢࢿࣇ࣮ࣟࢮ⑕ೃ⩌෌Ⓨ࡟ྜేࡋࡓ⬻㟼⬦Ὕ⾑ᰦ⑕ࡢ୍౛
➨ 45 ᅇ᪥ᮏ⭈⮚Ꮫす㒊Ꮫ⾡኱఍ࠊ㔠ἑࠊ2015.10.23-24
᳃ ┤ᕫ, 㛛ᯇ ㈼, 㧗ᶫ ฼ዉ, ⏣ᓥ ᜨⳀ㤶, ᮾ㑚 ⨾㔛, ⸨ᮧ ៞Ꮚ, ⓑ▼ ῟୍,
㧗ᶫ ၨ, ᯇᾆ ཭୍
⫗ⱆ⭘ᛶ⾑⟶⅖ࢆక࠺⫗ⱆ⭘ᛶ㛫㉁ᛶ⭈⅖ࡢཎᅉ㚷ู࡟ⱞ៖ࡋࡓ୍౛
➨ 45 ᅇ᪥ᮏ⭈⮚Ꮫ఍ᮾ㒊Ꮫ⾡኱఍ࠊᮾி ༊ࠊ2015.10.2-3
― 132 ―
ᮾ㑚 ⨾㔛, ᯇᾆ ཭୍, ⏣ᓥ ᜨⳀ㤶, 㧗ᶫ ฼ዉ, ᳃ ┤ᕫ, ᒾᓮ ᫀᶞ, ⓑ▼ ῟୍,
㛛ᯇ ㈼
㐍⾜ᛶ⫶⒴ࡢ໬Ꮫ⒪ἲ୰࡟ Proliferative Glomerulonephritis with Monoclonal IgG
Deposits(PGNMID)ࢆㄆࡵࡓ୍౛
➨ 45 ᅇ᪥ᮏ⭈⮚Ꮫ఍ᮾ㒊Ꮫ⾡኱఍ࠊᮾி ༊ࠊ2015.10.2-3
ᯇᾆ ཭୍, ᳃ ┤ᕫ, 㧗ᶫ ฼ዉ, ⏣ᓥ ᜨⳀ㤶, ᮾ㑚 ⨾㔛, ⸨ᮧ ៞Ꮚ, ᒾᓮ ᫀᶞ,
ⓑ▼ ῟୍, 㛛ᯇ ㈼
࢖࣐ࢳࢽࣈ࡟ࡼࡿ⾑ᰦᛶᚤᑠ⾑⟶㞀ᐖ⑕ࢆ␲ࡗࡓ୍౛
➨ 45 ᅇ᪥ᮏ⭈⮚Ꮫ఍ᮾ㒊Ꮫ⾡኱఍ࠊᮾி ༊ࠊ2015.10.2-3
ᮾ㑚 ⨾㔛, ᭹㒊 ྜྷᡂ, ᯇ஭ ᾈ㍜, ᳃ ┤ᕫ, ᒾᓮ ᫀᶞ, 㛛ᯇ ㈼, ❑⏣ ᐇ, ᯇᾆ ཭୍
኱⥙ษ㝖⾡ᚋ࡟኱⥙ᕳ⤡ࡢ෌Ⓨࢆㄆࡵࡓ⭡⭷㏱ᯒᑟධᝈ⪅ࡢ୍౛
➨ 60 ᅇ᪥ᮏ㏱ᯒ་Ꮫ఍Ꮫ⾡㞟఍⥲఍ࠊᶓ὾ࠊ2015.6.26-28
᳃ ┤ᕫ, ᮾ㑚 ⨾㔛, ᒾᓮ ᫀᶞ, 㛛ᯇ ㈼, ⣽ᑿ ဏᏊ, ᑠᒣ⏣ ྜྷᏕ, ᯇᾆ ཭୍
๻⑕ᆺ A ⩌ ǃ ⁐㐃⳦ឤᰁ⑕ࢆዎᶵ࡟↓ᒀ࡜࡞ࡾ⾑ᾮ㏱ᯒࢆᚲせ࡜ࡋࡓ୍౛
➨ 60 ᅇ᪥ᮏ㏱ᯒ་Ꮫ఍Ꮫ⾡㞟఍⥲఍ࠊᶓ὾ࠊ2015.6.26-28
ᇛ ⌮⤮, ᒾ℩ ᜤᏊ, ஂ⏣ ἞⨾, ᯇᾆ ཭୍, 㛛ᯇ ㈼, ኱ᓥ ஂ஧
ࢫࢸࣟ࢖ࢻ⿵඘㛤ጞᚋ 5 ᪥┠࡟㏥⦰ࢆㄆࡵࡓ IgG4 㛵㐃ୗᆶయ⅖ࡢ୍౛
➨ 88 ᅇ᪥ᮏෆศἪᏛ఍Ꮫ⾡⥲఍ࠊᮾி༓௦⏣༊ࠊ2015.4.23-25
[ㅮ₇]
ᑿ⸨ㄔྖ
ᝈ⪅ࡢពᛮỴᐃᨭ᥼࡟㛵ࡍࡿㅮ₇
➨ 5 ᅇࡀࢇ໬Ꮫ⒪ἲຮᙉ఍ࠊᒱ㜧┴㫽⩚㒆ࠊ2015.2.6
ᑿ⸨ㄔྖ
་⒪࡟࠾ࡅࡿࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒࡜ࡣఱ࠿
ᮐᖠ་⛉኱Ꮫࠊ໭ᾏ㐨ᮐᖠᕷࠊ2015.3.13
ᑿ⸨ㄔྖ
་⒪ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ࡟ࡘ࠸࡚
ᡞ⏣୰ኸ┳ㆤᑓ㛛Ꮫᰯࠊᇸ⋢┴ᡞ⏣ᕷࠊ2015.4.16
ᑿ⸨ㄔྖ
ࢢ࣮ࣝࣉ◊ಟ㸦Teem STEPPS㸧
➨ 19 ᅇ㛵ಙᆅ༊ᅜ❧⑓㝔⸆๣ᖌ఍᪂௵◊ಟ఍ࠊᮾி㒔┠㯮༊ࠊ2015.6.6
― 133 ―
ᑿ⸨ㄔྖ
་ࡢ೔⌮Ꮫ࣭♫఍Ꮫ
ᮾ໭኱Ꮫࠊᐑᇛ┴௝ྎᕷࠊ2015.6.8
ᑿ⸨ㄔྖ
⦆࿴་⒪࡟࠾ࡅࡿ་⒪ᑓ㛛⫋ࡢࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒
➨ 19 ᅇ᪥ᮏ⦆࿴་⒪Ꮫ఍ᩍ⫱ࢭ࣑ࢼ࣮ࠊ⚄ዉᕝ┴ᶓ὾ᕷࠊ2015.6.18
ᑿ⸨ㄔྖ
ᝈ⪅㸫་⒪⪅ࠊ་⒪⪅㸫་⒪⪅ࡢࡼࡾⰋ࠸㛵ಀ࡙ࡃࡾ࡟ࡘ࠸࡚
➨ 2 ᒸᮏ⥲ྜ⑓㝔 ➨ 12 ᅇࠕᆅᇦ㐃ᦠࡢኤ࡭ࠖࠊி㒔ᗓᏱ἞ᕷࠊ2015.7.11
ᑿ⸨ㄔྖ
ࠕ་⒪࡜ᑐே᥼ຓ࡟࠾ࡅࡿࢼࣛࢸ࢕ࣈ࣭࢔ࣉ࣮ࣟࢳࠖ
ㄒࡾ࠿ࡽ⣳ࡄ᥼ຓࡢ㛵ಀᛶࢆᏛࡪ ⥲ྜデ⒪࡟࠾ࡅࡿᝈ⪅ࡢㄒࡾ࡟࡝࠺ྥࡁྜ࠺࠿
LPC ᅜ㝿ࣇ࢛࣮࣒ࣛ 2015 ࡼࡾ㉁ࡢ㧗࠸ࢣ࢔ࢆ┠ᣦࡍ Next Stepࠊᮾி㒔୰ኸ༊ࠊ
2015.8.8
ᑿ⸨ㄔྖ
ᩆᛴ࣭㞟୰἞⒪࡟࠾ࡅࡿ⥲ྜෆ⛉་࡜ࡋ࡚ࡢどⅬ࡟ࡘ࠸࡚
ᒱ㜧ᩆᛴ㞟୰἞⒪ࢭ࣑ࢼ࣮ࠊᒱ㜧┴ᒱ㜧ᕷࠊ2015.9.18
ᑿ⸨ㄔྖ
ࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒㸦ᣦᑟ་ࡢᅾࡾ᪉㸧
ឡோ఍་ᖌ⮫ᗋ◊ಟᣦᑟ་ࢭ࣑ࢼ࣮ࠊ኱㜰ᗓ㧗ᵳᕷࠊ2015.9.27
ᑿ⸨ㄔྖ
་⒪ᑓ㛛⫋࡟ᚲせ࡞ࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒
ᖹᡂ 27 ᖺᗘ୰ᑠ࣭⢭⚄࣭⒪㣴⸆๣ᖌᐇ㊶ࢭ࣑ࢼ࣮ࠊ኱㜰ᗓ኱㜰ᕷࠊ2015.10.10
ᑿ⸨ㄔྖ
▱⬟ᶵᲔ᝟ሗᏛ≉ูㅮ⩏
ᮾி኱Ꮫ኱Ꮫ㝔᝟ሗ⌮ᕤᏛ⣔◊✲⛉ࠊᮾி㒔ᩥி༊ࠊ2015.10.7
ᑿ⸨ㄔྖ
᪥ᖖ⮫ᗋ࡛㐼㐝ࡍࡿ೔⌮ࢪ࣐ࣞࣥ㸸ࡑࡢ⪃࠼᪉࡜ពᛮỴᐃ
ᮾி࣋࢖࣭ᾆᏳᕷᕝ་⒪ࢭࣥࢱ࣮ ೔⌮࡟㛵ࡍࡿㅮ₇఍ࠊ༓ⴥ┴ᾆᏳᕷࠊ2015.10.13
ᑿ⸨ㄔྖ
་⒪ᶵ㛵ࡢ࠿࠿ࡾ᪉ࠊ㑅ࡧ᪉
Ύ℩ᕷ≉ᐃಖ೺ᣦᑟ஦ᴗࠊᮾி㒔Ύ℩ᕷࠊ2015.10.27
― 134 ―
ᑿ⸨ㄔྖ
་⒪࡜࡝࠺௜ࡁྜ࠺࠿
༓ⴥᕷ༠ാ஦ᴗ ➨ 2 ᅇཷデࢧ࣏࣮ࢱ࣮㣴ᡂㅮᗙࠊ༓ⴥ┴༓ⴥᕷࠊ2015.11.14
ᑿ⸨ㄔྖ
་⒪࡜♫఍
⚟ᓥ┴❧་⛉኱Ꮫࠊ⚟ᓥ┴⚟ᓥᕷࠊ2015.11.20
ᑿ⸨ㄔྖ
⸆࡟㛵ࡍࡿ᝟ሗࡢᤊ࠼᪉࡜⮫ᗋᛂ⏝࡟ࡘ࠸࡚
ᮾᾏ⸆๣ᖌᏛ⾡኱఍ࠊ୕㔜┴ᅄ᪥ᕷᕷࠊ2015.11.29
ᑿ⸨ㄔྖ
⑓㝔ᶵ⬟ホ౯ཷᑂ࡟࠶ࡓࡗ࡚ࡢ࣏࢖ࣥࢺ࡜ࡣ
ᅜ❧ᅜ㝿་⒪◊✲ࢭࣥࢱ࣮⫋ဨྥࡅㅮ⩦఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.12.2
ᑿ⸨ㄔྖ
ࡇࢀ࠿ࡽࡢᝈ⪅Ᏻ඲࡜࢖ࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺ
㹼┦஫ಙ㢗ࢆ┠ᣦࡍࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࡢ࠶ࡾ᪉࡟ࡘ࠸࡚㹼
㛵ᮾಙ㉺ཌ⏕ᒁ ᖹᡂ㸰㸵ᖺᗘ་⒪Ᏻ඲࡟㛵ࡍࡿ࣮࣡ࢡࢩࣙࢵࣉࠊࡉ࠸ࡓࡲᕷࠊ
2015.12.15
ᾆᒸಇኵ
Extra-wide-angle-view colonoscope
➨ 14 ᅇ኱⭠⏬ീ࢔࢝ࢹ࣑࣮ࠊᮾி༓௦⏣༊ࠊ2015.1
ᾆᒸಇኵ
᳨デ࡛Ẽ࡟࡞ࡿࣆࣟࣜ⳦࡜౽₯⾑᳨ᰝ
ᕷẸබ㛤ㅮᗙࠕ኱ே࡜Ꮚ౪ࡢ࠾࡞࠿ࡢ⑓Ẽ࡟ࡘ࠸࡚ࠖࠊᮾி┠㯮༊ࠊ2015.3
Uraoka T
Dual knife technique. 7th Workshop on ESD Expert Training
7th ESD Expert Training Workshop, Saltzburg/Austria㸪2015.6
Uraoka T
Clipping of ESD-margin- vs. ESD -ground-, perforation, Loop trick
7th ESD Expert Training Workshop㸪Saltzburg/Austria㸪2015.6
Uraoka T
Three-hands-technique, Skills and Strategies for ESD
7th Endoskills Update 2015㸪Saltzburg/Austria㸪2015.6
― 135 ―
ᾆᒸಇኵ
ࡇࡇࡲ࡛࡛ࡁࡿᾘ໬⟶ෆど㙾デ᩿࡜἞⒪
ᮾࡀୣᾘ໬ჾ⑓デ㐃ᦠࡢ఍ࠊᮾி㒔῰㇂༊ࠊ2015.6
ᾆᒸಇኵ
኱⭠ Polypectomy࣭EMR ࡢࢥࢶ࡜᭱㏆ࡢヰ㢟
㟷᳃┴ Polypectomy ࢭ࣑ࢼ࣮ࠊ㟷᳃┴㟷᳃ᕷࠊ2015.9
ᾆᒸಇኵ
኱⭠ෆど㙾἞⒪ࢆ⾜࠺ୖ࡛ᚲせ࡞ࡇ࡜ 㹼 ࣏ࣜ࣌ࢡࢺ࣑࣮࠿ࡽ ESD ࡲ࡛ 㹼
➨ 4 ᅇ ᰣᮌᾘ໬ჾ CLUB Jr.ࠊᰣᮌ┴Ᏹ㒔ᐑᕷࠊ2015.9
Uraoka T
Practical Tips for ESD Beginners and Management of Common Complications
INTERNATIONAL ESD LIVE MADRID 2015㸪Madrid/Spain㸪2015.9
ᾆᒸಇኵ
⣽ᚄ໬࡜ከᶵ⬟໬ࢆᐇ⌧ࡋࡓෆど㙾ࢆ⏝࠸ࡓ኱⭠ࡀࢇࢫࢡ࣮ࣜࢽࣥࢢ
JDDW 2015㸦➨ 53 ᅇ᪥ᮏᾘ໬ჾࡀࢇ᳨デᏛ఍኱఍㸧࣭ࢧࢸࣛ࢖ࢺࢩ࣏ࣥࢪ࣒࢘ࠊ
ᮾி㒔ရᕝ༊ࠊ2015.10
ᾆᒸಇኵ
ESD ࡟࠾ࡅࡿᏳ඲἞⒪ᡓ␎ 㹼അⓎ⑕ᑐ⟇㹼
➨ 6 ᅇᗈᓥ EMR/ESD ࣁࣥࢬ࢜ࣥࢭ࣑ࢼ࣮ࠊᗈᓥ┴ᗈᓥᕷࠊ2015.11
ᾆᒸಇኵ
Ᏻ඲࣭☜ᐇ࣭ࢫࣆ࣮ࢹ࢕࣮࡞ ESD ࢆ┠ᣦࡋ࡚
㸫 ᶆ‽ⓗ⑓ኚ࠿ࡽᢏ⾡ⓗᅔ㞴౛ࡲ࡛ 㸫
➨ 106 ᅇ᪥ᮏᾘ໬ჾ⑓Ꮫ఍஑ᕞᨭ㒊౛఍ / ➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍஑ᕞᨭ㒊౛
఍࣭ࣛࣥࢳࣙࣥࢭ࣑ࢼ࣮ࠊ⚟ᒸ┴⚟ᒸᕷࠊ2015.12
ᾆᒸಇኵ
⾲㠃ᆺ኱⭠⭘⒆࡟ᑐࡍࡿෆど㙾デ᩿࣭἞⒪࡬ࡢࢳࣕࣞࣥࢪ
⮫ᗋ࡜⑓⌮ࡢ᥋Ⅼࢆ⪃࠼ࡿ఍ 㹼⮫ᗋ࣭⑓⌮࡟࠾ࡅࡿࣈࣜࢵࢪ◊✲㹼ࠊᒾᡭ┴┒ᒸᕷࠊ
2015.12
㧘ᯘ 㤾
㛗ᘬࡃ⭡③࣭ୗ⑩࣭⾑౽ࢆࡳࡓࡽ㹼⭠ࡢ⌧௦⑓ ⅖⑕ᛶ⭠⑌ᝈࡢ⑓ែ࡜἞⒪㹼
ᮾி་⒪ࢭࣥࢱ࣮ᕷẸබ㛤ㅮᗙࠊᮾி㒔┠㯮༊ࠊ2015.3
― 136 ―
㧘ᯘ 㤾
⅖⑕ᛶ⭠⑌ᝈࡢデ᩿࡜἞⒪ –⑓デ㐃ᦠࡢどⅬ࠿ࡽୡ⏣㇂༊┠㯮༊་ᖌ఍ㅮ₇ࠊᮾி㒔῰㇂༊ࠊ2015.4
㧘ᯘ 㤾
⅖⑕ᛶ⭠⑌ᝈࡢデ᩿࡜἞⒪
ᇛ༡ IBD ࣇ࢛࣮࣒ࣛࠊᮾி㒔᪂ᐟ༊ࠊ2015.8
㧘ᯘ 㤾
⅖⑕ᛶ⭠⑌ᝈࡢデ᩿࡜἞⒪ –⪃࠼᪉࡜᭱㏆ࡢࢺࣆࢵࢡᮾࡀୣᾘ໬⟶ࢿࢵࢺ࣮࣡ࢡࠊᮾி㒔┠㯮༊ࠊ2015.11
ຍ⸨ඖᙪ
ୖ㒊ᾘ໬⟶⭘⒆࡟ᑐࡍࡿෆど㙾἞⒪ࡢ up to date ࠥṧࡉࢀࡓㄢ㢟࡜ࡣ㸽ࠥ
㤶ᕝᾘ໬ჾ᠓ぶ఍ࠊ㤶ᕝࠊ2015 ᖺ 1 ᭶ 17 ᪥
ຍ⸨ඖᙪ
⫶⑌ᝈ࡟ᑐࡍࡿෆど㙾デ᩿ࡢࠕࡇࢀࡲ࡛ࠖ࡜ࠕࡇࢀ࠿ࡽࠖ
➨ 101 ᅇᮾி་⒪ࢭࣥࢱ࣮ᆅᇦ་⒪࢝ࣥࣇ࢓ࣞࣥࢫࠊᮾிࠊ2015.5.21
ຍ⸨ඖᙪ
Case conference 2 ⫶ ESD
ESD Forum Kobe 2015ࠊ⚄ᡞࠊ2015.6.5
ຍ⸨ඖᙪ
ୖ㒊ᾘ໬⟶ ESD ᚋࡢ㐺ษ࡞ࢧ࣮࣋࢖ࣛࣥࢫἲ࡟ࡘ࠸࡚
ᮾࡀୣᾘ໬ჾࢿࢵࢺ࣮࣡ࢡࠊᮾிࠊ2015.6.30
ຍ⸨ඖᙪ
⑕౛᳨ウࢭࢵࢩࣙࣥ㸱ࠕ⫶ࠖᣦᐃㄞᙳ་
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾிࠊ2015.6.14
⳥ụ┿኱
NASH࣭ASH ࡟ࡘ࠸࡚
Medical Association Hepatitis Seminarࠊᮾிࠊ2015.11.27
⳥ụ┿኱
἞ࡑ࠺㸟࠶࡞ࡓࡢ⬡⫫⫢
➨ 30 ᅇ⫢⮚⑓ᩍᐊࠊᮾிࠊ2015.10.17
― 137 ―
⳥ụ┿኱
ᙜ㝔࡟࠾ࡅࡿ⮅⟶ࢫࢸࣥࢺ⤒㦂౛
Pancreatic stent ◊✲఍ࠊᮾிࠊ2015.8.19
⳥ụ┿኱
⫢ࡀࢇ࡟ࡘ࠸࡚
➨ 29 ᅇ⫢⮚⑓ᩍᐊࠊᮾிࠊ2015.7.18
⳥ụ┿኱
⫢⑌ᝈࡢኚ㑄࡜⬡⫫⫢デ⒪
ᮾி་⒪ࢭࣥࢱ࣮་ᒁබ㛤ㅮᗙ࢝ࣥࣇ࢓ࣞࣥࢫࠊᮾிࠊ2015.7.9
⳥ụ┿኱
ኵ፬㛫ឤᰁࡢྍ⬟ᛶࡀ⪃࠼ࡽࢀࡓᛴᛶ C ᆺ⫢⅖ࡢ៏ᛶ໬౛
ᇛ༡⫢⑌ᝈࣇ࢛࣮࣒ࣛࠊᮾிࠊ2015.6.3
⳥ụ┿኱
⫢⮚࡜⏕ά⩦័⑓
┠㯮༊ෆ⛉㒊఍Ꮫ⾡ㅮ₇఍ࠊᮾி, 2015.5.13
⳥ụ┿኱
⫢⑌ᝈ᳨ᰝ್ࡢぢ᪉
ᮾி་⒪ࢭࣥࢱ࣮ ࣭➨ 28 ᅇ⫢⮚⑓ᩍᐊࠊᮾிࠊ2015.4.11
⳥ụ┿኱
⬡⫫⫢ࢆぢ㏨ࡋ࡚࠸ࡲࡏࢇ࠿㹼࣓ࢱ࣎᫬௦࡟ࠊࡼࡾ㧗⢭ᗘࡢ⬡⫫⫢ࠊ⫢⥺⥔໬デ᩿
ࢆࠋ㠀౵くⓗᐃ㔞 ᐃ CAP ᦚ㍕ Fibroscan ࡢ᭷⏝ᛶ㹼
➨ 43 ᅇ ᪥ᮏ⥲ྜ೺デᏛ఍ ࣛࣥࢳࣙࣥࢭ࣑ࢼ࣮ࠊᐩᒣࠊ 2015.2.20
⳥ụ┿኱
⫢⑌ᝈ࡜⏕ά⩦័⑓
➨ 98 ᅇᮾி་⒪ࢭࣥࢱ࣮ᆅᇦ་⒪࢝ࣥࣇ࢓ࣞࣥࢫࠊᮾிࠊ2015.1.29
⳥ụ┿኱
㣧㓇࡜⫢㞀ᐖ
ᮾி་⒪ࢭࣥࢱ࣮ ࣭➨ 27 ᅇ⫢⮚⑓ᩍᐊࠊᮾிࠊ2015.1.17
᳃ఙ᫭
⌧ሙ࡟࠾ࡅࡿ CRE ᑐ⟇ࡢၥ㢟Ⅼ࡜ㄢ㢟
➨ 22 ᅇ࢖ࣥࣇ࢙ࢡࢩࣙࣥࢥࣥࢺ࣮ࣟࣝࢭ࣑ࢼ࣮ࠊᮾி኱⏣༊ࠊ2015.7.10
― 138 ―
᳃ఙ᫭
ᕷ୰⑓㝔࡛ CRE ࡛ᅔࡗ࡚࠸ࡿࡇ࡜
➨ 4 ᅇឤᰁ⑕἞⒪ᡓ␎఍㆟ࠊᮾிࠊ2015.11.8
᳃ఙ᫭
ࢡࣟࢫࢺࣜࢪ࣒࣭࢘ࢹ࢕ࣇ࢕ࢩࣝឤᰁ⑕࡟ࡘ࠸࡚ࠥ⤒⟶ᰤ㣴ࡢどⅬࡶධࢀ࡚ࠥ
➨ 17 ᅇ༊す༡㒊⥲ྜデ⒪࣭ឤᰁ⑕◊✲఍ࠊᮾி┠㯮༊ࠊ2015.11.12
ᯇᮧ┿ྖ
ᆅᇦࡢデ⒪ᡤ࡟࠾ࡅࡿࣉࣛ࢖࣐࣭ࣜࢣ࢔ࡢホ౯ࡢヨࡳ
ᮾி኱Ꮫ་Ꮫᩍ⫱ࢭ࣑ࢼ࣮ࠊᮾி㒔ᩥி༊ࠊ2015.9.2
㣤ᒸ⥴⨾㸪᫓⏣῟ᚿ ௚
」㞧ᛶࡢどⅬ࡛ከ⫋✀࡛ࡢ஦౛᳨ウࢆ᣺ࡾ㏉ࡿ
➨ 55 ᅇ་Ꮫᩍ⫱ࢭ࣑ࢼ࣮࡜࣮࣡ࢡࢩࣙࢵࣉࠊᒱ㜧ᕷࠊ2015.2.1
㣤ᒸ⥴⨾
␲⩏↷఍࡟㛵ࡍࡿࣉࣟࢺࢥ࣮ࣝ໬࡟ࡼࡿṧ⸆ㄪᩚ࡜᭹⸆࢔ࢻࣄ࢔ࣛࣥࢫࡢྥୖ
ࡇࢀ࠿ࡽࡢ་⸆࣭⸆⸆㐃ᦠࢆ⪃࠼ࡿࠊᮾி㒔ᩥி༊ࠊ2015.6.16
㣤ᒸ⥴⨾ ௚
➨ 11 ᅇ RIAS ࢺ࣮ࣞࢽࣥࢢ࣮࣡ࢡࢩࣙࢵࣉ
RIAS Japanࠊᒱ㜧ᕷࠊ2015.8.7-9
㣤ᒸ⥴⨾ࠊDebra Roterࠊ㔝࿅ᗄஂᏊ
་⒪࡟࠾ࡅࡿࢪ࢙ࣥࢲ࣮࡜ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ
➨ 57 ᅇ་Ꮫᩍ⫱ࢭ࣑ࢼ࣮࡜࣮࣡ࢡࢩࣙࢵࣉࠊᒱ㜧ᕷࠊ2015.8.9
㣤ᒸ⥴⨾ࠊᏞ኱㍜
ࣉࣛ࢖࣐ࣜࢣ࢔ㄆᐃ⸆๣ᖌ࣏࣮ࢺࣇ࢛ࣜ࢜Ⓨ⾲఍࣭ㅮ₇
᪥ᮏࣉࣛ࢖࣐࣭ࣜࢣ࢔Ꮫ఍ㄆᐃ⸆๣ᖌ◊ಟ఍ࠊᮾி㒔ᩥி༊ࠊ2015.10.11
[ࡑࡢ௚]
ᑿ⸨ㄔྖ
㸦ᰯ㜀㸧ከᵝᛶ᫬௦ࡢ་⒪ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ-᪂ࡋ࠸ಙ㢗㛵ಀࢭ࣑ࢼ࣮ሗ࿌᭩
LPC ᅜ㝿ࣇ࢛࣮࣒ࣛ 2014 ࡼࡾ㉁ࡢ㧗࠸་⒪ࢆ┠ᣦࡍ Next Stepࠊ2015.2
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧ࠗࠕ་ᖌ࢔ࢱ࣐ࠖ࡜ࡢ௜ࡁྜ࠸᪉ ᝈ⪅࡜་⪅ࡣࢃ࠿ࡾ࠶࠼ࡿ࠿
୰ኸබㄽ᪂♫ࡼࡾᘬ⏝ ಙᕞ኱Ꮫ 2012 ᖺᗘධヨၥ㢟
Ꮫᰯἲே㥴ἙྎᏛᅬ㥴ྎணഛᏛᰯᩍᮦࠊ2015.4
2015 ᖺᗘ∧ධヨၥ㢟ࢹ࣮ࢱ࣮࣋ࢫ࡬ࡢᥖ㍕ࠊ2015.6
― 139 ―
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧ࠕ་ᖌ࢔ࢱ࣐ࠖ་Ꮫ᭩㝔ࡼࡾᘬ⏝ ᒣཱྀ኱Ꮫ 2014 ᖺᗘධヨၥ㢟
Ꮫᰯἲே㥴ἙྎᏛᅬ㥴ྎணഛᏛᰯᩍᮦࠊ2015.4
2015 ᖺᗘ∧ධヨၥ㢟ࢹ࣮ࢱ࣮࣋ࢫ࡬ࡢᥖ㍕ࠊ2015.6
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧ࠕ་ᖌ࢔ࢱ࣐㸫་ᖌ࡜ᝈ⪅ࡣ࡞ࡐࡍࢀ㐪࠺ࡢ࠿㸽ࠖ་Ꮫ᭩㝔
2016-2018 ᖺ∧኱Ꮫධヨࢩ࣮ࣜࢬࠕᅜබ❧኱ࠖ་Ꮫ㒊་Ꮫ⛉ ᥎⸀ 㸿㹍ධヨ
ᰴᘧ఍♫ୡ⏺ᛮ᝿♫ᩍᏛ♫ࠊ2015.5
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧་ᖌࡢ㢌ࡢ୰ࡣࠕ࢖ࢩ࢔ࢱ࣐࡛ࠖ࠶ࡿ㸦ࠕ་ᖌ࢔ࢱ࣐ࠖᡤ཰㸧
ᒣཱྀ኱Ꮫධヨၥ㢟
኱Ꮫධヨࢹ࣮ࢱ࣮࣋ࢫ 2014 ᖺᗘ㧗ᰯඹ㏻ Web ࡬ࡢ㌿㍕ࠊᰴᘧ఍♫࣋ࢿࢵࢭࢥ࣮࣏
࣮ࣞࢩࣙࣥࠊ2015.6
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧ࠕ་ᖌ࢔ࢱ࣐ࠖ࡜ࡢ௜ࡁྜ࠸᪉㸫ᝈ⪅࡜་⪅ࡣࢃ࠿ࡾ࠶࠼ࡿ࠿
2012 ᖺಙᕞ኱Ꮫධヨၥ㢟
ཷ㦂ㅮᗙ ᑠㄽᩥ㐣ཤၥᑐ⟇ 2015㸫2017 ᖺᗘ㧗ᰯ 3 Web ࡬ࡢ㌿㍕ࠊ2015.6
ᑿ⸨ㄔྖ
㸦ᰯ㜀㸧
ࠕ⮫ᗋ◊✲࡟࠾ࡅࡿ೔⌮࡜◊✲⪅ࡢࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒ࠖ
㸦➨ 36 ᅇ᪥ᮏ⑓
㝔⸆๣ᖌ఍ ᐇົ◊ಟ఍࡛ࡢㅮ₇ࡢᥖ㍕㸧࡟࠾ࡅࡿࢧ࢖ࢺࢹ࣮ࢱࡢᰯ㜀ࠊ☜ㄆࢸࢫࢺࡢ
ᰯ㜀ࠊ୍⯡♫ᅋἲே ᪥ᮏ⑓㝔⸆๣ᖌ఍ࡢ e-࣮ࣛࢽࣥࢢࠊ2015.10
ᑿ⸨ㄔྖ
㸦ㅮᖌࠊࣇ࢓ࢩࣜࢸ࣮ࢱ࠾ࡼࡧ࢖ࣥࢱࣅࣗ࢔࣮㸧ᖹᡂ 26 ᖺᗘே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ
་⒪యไᩚഛ஦ᴗᡂᯝሗ࿌఍ ࢢ࣮ࣝࣉ࣮࣡ࢡཬࡧ┦ㄯဨ࡬ࡢ࢖ࣥࢱࣅ࣮ࣗ
ឡ▱┴኱ᗓᕷࠊ2015.2.21
ᑿ⸨ㄔྖ
㸦ᗙㄯ఍࡟࠾ࡅࡿㄽ㆟㸧⤊ᮎᮇ་⒪
୍⯡♫ᅋἲே࿧྾◊✲ࠊᮾி㒔༓௦⏣༊ࠊ2015.3.27
ᑿ⸨ㄔྖ
㸦ᩍᮦࡢసᡂ㸧་⒪೔⌮࣭ࣉࣟࣇ࢙ࢵࢩࣙࢼࣜࢬ࣒࡟㛵ࡍࡿ㹃-࣮ࣛࢽࣥࢢᩍᮦ
ᰴᘧ఍♫ࣜࣥࢡ࢔ࣥࢻࢣ࢔࣭ࣛ࢖ࣇ Clinical Practice Academia-CLiPࠊ2015.5.8
― 140 ―
ᑿ⸨ㄔྖ
㸦㈨᱁ㄆᐃヨ㦂ၥ㢟సᡂ㸧➨ 110 ᅇ་ᖌᅜᐙヨ㦂ཬࡧᖹᡂ 27 ᖺᗘ་ᖌᅜᐙヨ㦂ணഛヨ
㦂ၥ㢟ࡢసᡂ
ཌ⏕ປാ┬་ᨻᒁࠊᮾி㒔༓௦⏣༊ࠊ2015.5.26-27
ᑿ⸨ㄔྖ
㸦ⴭ᭩ࡢ୍㒊౑⏝㸧ࠕ་ᖌ࢔ࢱ࣐ࠖ࡜ࡢ௜ࡁྜ࠸᪉ ᝈ⪅࡜་⪅ࡣࢃ࠿ࡾ࠶࠼ࡿ࠿
Ꮫᰯἲே㧗ᐑᏛᅬ௦ࠎᮌࢮ࣑ࢼ࣮ࣝ,ࠕ་⣔ᑠㄽᩥࠖ࡬ࡢᥖ㍕ࠊ2015.9.1-2015.12.5
ᑿ⸨ㄔྖ
㸦ウㄽ㸧ᖹᡂ 27 ᖺᗘே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ་⒪యไᩚഛ஦ᴗࣉࣟࢢ᳨࣒ࣛウ఍࡟࠾
ࡅࡿ┦ㄯဨ◊ಟࣉࣟࢢ࣒ࣛ࡟ࡘ࠸࡚ࡢウㄽ
ᮾி㒔୰ኸ༊ࠊ2015.7.2
ᑿ⸨ㄔྖ
㸦ࣇ࢓ࢩࣜࢸ࣮ࢱ㸧࣮࣡ࢡࢩࣙࢵࣉࠕࢼࣛࢸ࢕ࣈ࣭ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥࢆ㣴࠺ࠖ
ࢹ࢕ࢫ࢝ࢵࢩࣙࣥࠕᝈ⪅࡜Ṍࡴࢼࣛࢸ࢕ࣈ࣭࢔ࣉ࣮ࣟࢳࡢᾐ㏱ࡢࡓࡵ࡟ࠖ
LPC ᅜ㝿ࣇ࢛࣮࣒ࣛ 2015 ࡼࡾ㉁ࡢ㧗࠸ࢣ࢔ࢆ┠ᣦࡍ Next Stepࠕ་⒪࡜㏥㝕᥼ຓ࡟
࠾ࡅࡿࢼࣛࢸ࢕ࣈ࣭࢔ࣉ࣮ࣟࢳࠖㄒࡾ࠿ࡽ⣳ࡄ᥼ຓࡢ㛵ಀᛶࢆᏛࡪࠊᮾி㒔୰ኸ༊ࠊ
2015.8.9
ᑿ⸨ㄔྖ
㸦◊ಟ࡟࠾ࡅࡿㅮᖌ㸧ᖹᡂ 27 ᖺᗘே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ་⒪యไᩚഛ஦ᴗ┦ㄯဨ
◊ಟ఍ࠊᮾி㒔ᩥி༊ࠊ2015.8.12-13
ᑿ⸨ㄔྖ
㸦ࣇ࢓ࢩࣜࢸ࣮ࢱ㸧ᖹᡂ 27 ᖺᗘே⏕ࡢ᭱⤊ẁ㝵࡟࠾ࡅࡿ་⒪యไᩚഛ஦ᴗ୰㛫ሗ࿌఍
ࢢ࣮ࣝࣉ࣮࣡ࢡ
ᮾி㒔༓௦⏣༊ࠊ2015.11.4
ᑿ⸨ㄔྖ
㸦㈨᱁ㄆᐃヨ㦂ၥ㢟సᡂ㸧ᖹᡂ 27 ᖺᗘ୍⯡♫ᅋἲே᪥ᮏෆ⛉Ꮫ఍㈨᱁ㄆᐃヨ㦂ၥ㢟
2015.9
ᑿ⸨ㄔྖ
㸦௻⏬⦅㞟㸧౯್࡟ᇶ࡙ࡃ་⒪㸫ᝈ⪅࡟࡜ࡗ࡚ࡢ᭱ၿࡢ㑅ᢥࢆ┠ᣦࡋ࡚
Modern Physician 36 ᕳ 5 ྕࠊ᪂⯆་Ꮫฟ∧♫
― 141 ―
Uraoka T
(ࣁࣥࢬ࢜ࣥࣞࢡࢳ࣮ࣕ)
7th Workshop on ESD Expert Training
Salzburg/Austria, 2015.6
Uraoka T
(ࣁࣥࢬ࢜ࣥࣞࢡࢳ࣮ࣕ)
INTERNATIONAL ESD LIVE MADRID 2015.㸪Madrid/Spain㸪2015.9
ᾆᒸಇኵ
(ࣁࣥࢬ࢜ࣥࣞࢡࢳ࣮ࣕ)
➨ 6 ᅇᗈᓥ EMR/ESD ࣁࣥࢬ࢜ࣥࢭ࣑ࢼ࣮ࠊᗈᓥ┴ᗈᓥᕷࠊ2015.11
ᾆᒸಇኵ
(ᗙ㛗)
ࠗୖ㒊ᾘ໬⟶⑌ᝈデ⒪࡬ࡢ᪂ࡓ࡞ࡿ࢔ࣉ࣮ࣟࢳ࠘₇⪅㸸៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊 ෆ⛉Ꮫ㸦ᾘ
໬ჾ㸧෸ᩍᤵ 㕥ᮌ ⚽࿴ ඛ⏕
ᾘ໬ჾ⑌ᝈࢆ⪃࠼ࡿ఍ࠊᮾி㒔῰㇂༊ࠊ2015.4
ᾆᒸಇኵ
(ᗙ㛗)
୍⯡ཱྀ₇㸦SSA/P㸧
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.5
ᾆᒸಇኵ
(ᗙ㛗)
୍⯡ཱྀ₇㸦⫶ ESD-4㸧
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.6
ᾆᒸಇኵ
(ᗙ㛗)
⑕౛᳨ウ࣭ㅮ₇
➨୍ᅇ࣭ᮾࡀୣᾘ໬ჾࢿࢵࢺ࣮࣡ࢡࠊᮾி㒔┠㯮༊ࠊ2015.8
ᾆᒸಇኵ
(ᗙ㛗)
ࠗ኱⭠ෆど㙾ࢺ࣮ࣞࢽࣥࢢἲ-⌧≧࡜ㄢ㢟-࠘㡰ኳᇽ኱Ꮫ་Ꮫ㒊 ᩍᤵ ᆏᮏ ┤ே ඛ⏕
COLONetwork 2015ࠊᮾி㒔༓௦⏣༊ࠊ2015.8
― 142 ―
ᾆᒸಇኵ
(ᗙ㛗)
⑕౛᳨ウ࣭ㅮ₇
➨ 11 ᅇ Gut Challenge Meetingࠊᮾி㒔Ụᮾ༊ࠊ2015.8
⳥ụ┿኱
(ᗙ㛗)
TACE
ᇛ༡⫢⑌ᝈࣇ࢛࣮࣒ࣛࠊᮾிࠊ2015.11.13
⳥ụ┿኱
(ᗙ㛗)
⭡㒊㉸㡢Ἴ
➨ 43 ᅇ᪥ᮏ⥲ྜ೺デᏛ఍ࠊᐩᒣࠊ2015.2.20
ᾆᒸಇኵ
(⑕౛᳨ウࢭࢵࢩࣙࣥࢥ࣓ࣥࢸ࣮ࢱ࣮)
➨ 12 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍Ꮫ⾡㞟఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.2
ᾆᒸಇኵ
(⑕౛᳨ウࢭࢵࢩࣙࣥㄞᙳ⪅)
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.6
ຍ⸨ඖᙪ
(⑕౛᳨ウࢭࢵࢩࣙࣥ㸱ࠕ⫶ࠖᣦᐃㄞᙳ་)
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍ࠊᮾிࠊ2015.6.14
ᾆᒸಇኵ
㌟㏆࡞⑓ẼࠊẼ࡟࡞ࡿ⑕≧ 㹼࠸ࡲ࡝ࡁࡣࡇ࠺┤ࡍ㸟㹼 ኱⭠࣏࣮ࣜࣉ㸦๓⦅㸧
ᮾிࢫ࣏࣮ࢶࠊ2015.10.20
ᾆᒸಇኵ
㌟㏆࡞⑓ẼࠊẼ࡟࡞ࡿ⑕≧ 㹼࠸ࡲ࡝ࡁࡣࡇ࠺┤ࡍ㸟㹼 ኱⭠࣏࣮ࣜࣉ㸦ᚋ⦅㸧
ᮾிࢫ࣏࣮ࢶࠊ2015.10.27
⳥ụ┿኱
㸦TV ฟ₇㸧ࣈࣟࢵࢥ࣮ࣜࢫࣉࣛ࢘ࢺ㸦SFN㸧ࡢຠᯝ
NHK ࢔ࢧ࢖ࢳࠊ2015.6.8
― 143 ―
⳥ụ┿኱
㸦TV ฟ₇㸧෤࡟೺ᗣண㜵ࡢࡓࡵ࡟㣗࡭ࡿ࡜Ⰻ࠸෤㔝⳯
TBS ࢧࢱࢹ࣮ࣉࣛࢫࠊ2015.11.28
᳃ఙ᫭
᪥⤒࣓ࢹ࢕࢝ࣝ REPORTࠕⓎ⇕ᝈ⪅࡟ࢹࣥࢢ⇕ࢆ␲ࡗࡓࡽࠖ2015.8
ࣛࢪ࢜ NIKKEI ᮥᯘࢩ࣏ࣥࢪ࢔ࠕClostridium difficile ឤᰁ⑕ࠖ2015.10.11
㛛ᯇ㈼
㸦ᗙ㛗㸧୍⯡₇㢟࣏ࢫࢱ࣮, PD ᇶ♏
➨ 60 ᅇ᪥ᮏ㏱ᯒ་Ꮫ఍Ꮫ⾡㞟఍⥲఍ࠊᶓ὾ࠊ2015.6.26-28
― 144 ―
㧗㱋⪅ࢣ࢔◊✲ᐊ
[ ⥲ㄝ ]
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ࠙≉㞟ࠚㄆ▱⑕㧗㱋⪅ࡢ⏕ά⎔ቃ ⪁ᖺ་Ꮫ࡟ᇶ࡙࠸ࡓ㧗㱋⪅࡬ࡢ࢔ࣉࣟ
࣮ࢳ࡜▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗࢣ࢔ᢏ⾡ Humanitude
⑓㝔タഛ 322 2015 ᖺ 3 ᭶ྕࠊ57(2)㸸31-35ࠊ୍⯡♫ᅋἲே᪥ᮏ་⒪⚟♴タഛ༠఍ࠊ
2015.3
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ᅾᏯ࣭ᆅᇦ࡟࠾ࡅࡿά⏝ྍ⬟ᛶ 㧗㱋⪅࡜ᐙ᪘ࡀᚲせ࡜ࡍࡿᅾᏯࢣ࢔࡜ࡣ
ㄆ▱⑕ࡢᐙ᪘௓ㆤ࡜࣐ࣘࢽࢳ࣮ࣗࢻࡢྍ⬟ᛶ
ᅾᏯ࣭ᆅᇦ࡛ࡇࡇࡲ࡛࡛ࡁࡿ㸟ゼၥ┳ㆤ࡜௓ㆤ 2015 ᖺ 5 ᭶ྕࠊ20(5)㸸368-373ࠊ་Ꮫ
᭩㝔ࠊ2015.5.15
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡࣐ࣘࢽࢳ࣮ࣗࢻ
᪥ᮏᅾᏯ་Ꮫ఍㞧ㄅ 2015 ᖺ 7 ᭶ࠊ17(1)㸸98ࠊ୍⯡♫ᅋἲே᪥ᮏᅾᏯ་Ꮫ఍ࠊ2015.7
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ඃࡋࡉࢆఏ࠼ࡿ▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗ࡞ࢣ࢔ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ
ᢏ⾡ ࣐ࣘࢽࢳ࣮ࣗࢻࠊ᭶ห⸆஦ 2015 ᖺ 11 ᭶ࠊ57(12)㸸93-97ࠊᰴᘧ఍♫ࡌ࡯࠺ࠊ
2015.11
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ⪁ᖺ་Ꮫ࡟ᇶ࡙࠸ࡓ㧗㱋⪅⪅࡬ࡢ࢔ࣉ࣮ࣟࢳ࡜▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿ
ໟᣓⓗࢣ࢔ᢏ⾡ Hunnanitude
ᦤ㣗࣭ᄟୗ㞀ᐖࢆ⪃࠼ࡿ ཱྀ࠿ࡽ㣗࡭ࡿᖾࡏ࡙ࡃࡾ࠙➨ 9 㞟ࠚ㸸4-7ࠊ㣗௓ㆤ◊✲఍
[ Ꮫ఍ ]
ᮏ⏣⨾࿴Ꮚ
(ࢩ࣏ࣥࢪ࣒࢘) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
᪥ᮏᅾᏯ་Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘ㄆ▱⑕ࢣ࢔ࡢ᰿ᖿࢆぢࡘࡵࡿ ➨ 17 ᅇ᪥ᮏᅾᏯ་Ꮫ఍ࡶ
ࡾ࠾࠿኱఍ࠊ┒ᒸᕷࠊ2015.4.26
ᮏ⏣⨾࿴Ꮚ
(ᩍ⫱ㅮ₇) ▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®ࡑࡢᇶᮏ࡜
ᐇ㊶
➨ 6 ᅇ᪥ᮏࣉࣛ࢖࣐ࣜࢣ࢔㐃ྜᏛ఍Ꮫ⾡኱఍ࠊࡘࡃࡤᕷࠊ2015.6.13
― 145 ―
ᮏ⏣⨾࿴Ꮚ
(ᩍ⫱ㅮ₇) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻࡢᐇ㊶
➨ 56 ᅇ᪥ᮏᚰ㌟་Ꮫ఍ࠊỤᡞᕝ༊ࠊ2015.6.26
ᮏ⏣⨾࿴Ꮚࠊ⮉⏿ᩔᏊ
(┳ㆤᢏ⾡ࢭ࣑ࢼ࣮) ࣐ࣘࢽࢳ࣮ࣗࢻ㸫ဴᏛ࡟ࡶ࡜࡙࠸ࡓᐇ㊶ⓗྡࢣ࢔ࡢᒎ㛤㸫ࠊ ࡏ࠸ࢀ࠸┳ㆤᏛ఍➨ 6 ᅇᏛ⾡㞟఍ࠊ὾ᯇᕷࠊ2015.9.12
ᮏ⏣⨾࿴Ꮚ
(ࢩ࣏ࣥࢪ࣒࢘) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
➨ 3 ᅇ ᪥ᮏ௓ㆤ⚟♴࣭೺ᗣ࡙ࡃࡾᏛ఍ࠊᯈᶫ༊ࠊ2015.11.15
ᮏ⏣⨾࿴Ꮚ
(≉ูㅮ₇) ㄆ▱⑕ࢣ࢔࡟࠾ࡅࡿ࣐ࣘࢽࢳ࣮ࣗࢻɆぢࡿ࣭ヰࡍ࣭ゐࢀࡿ࣭❧ࡘɆ
➨ 55 ᅇ㏆␥⌮Ꮫ⒪ἲᏛ⾡኱఍ࠊ⚄ᡞᕷࠊ2015.11.21
ᮏ⏣⨾࿴Ꮚ
(≉ูㅮ₇) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ࢯ࣮ࢩࣕࣝࢫ࢟ࣝࢺ࣮ࣞࢽࣥࢢᬑཬ༠఍➨ 20 ᅇᏛ⾡㞟఍ࠊ㇏୰ᕷࠊ2015.11.27
[ ㅮ₇ ]
ᮏ⏣⨾࿴Ꮚࠊఀᮾ⨾⥴
▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗࢣ࢔ᢏ⾡
ᮾி㒔೺ᗣ㛗ᑑ་⒪ࢭࣥࢱ࣮ㅮ₇ࠊᯈᶫ༊ࠊ2015.1.6
ᮏ⏣⨾࿴Ꮚ
▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ᇶ࡙ࡃࠊඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㸸࣐ࣘࢽࢳ࣮ࣗࢻ
໭ከᦶす㒊་⒪ᅪᆅᇦࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᨭ᥼ࢭࣥࢱ࣮බ㛤ㅮᗙࠊ❧ᕝᕷࠊ2015.1.15
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
࣐ࣘࢽࢳ࣮ࣗࢻࡑࡢேࡽࡋࡉࢆᅇ᚟ࡉࡏࡿࢣ࢔ᢏ⾡
⇃ᮏ┴ಖ㝤་༠఍ࠊ⇃ᮏᕷࠊ2015.1.17
ᮏ⏣⨾࿴Ꮚࠊఀᮾ⨾⥴
ᩍ⫱ㅮ₇ࡸࡉࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡࣐ࣘࢽࢳ࣮ࣗࢻ
㮵ᒇ┳ㆤᑓ㛛Ꮫᰯࠊ㮵ᒇᕷࠊ2015.1.19
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚࠊఀᮾ⨾⥴
ඃࡋࡉࢆఏ࠼ࡿᢏ⾡㹼࣐ࣘࢽࢳ࣮ࣗࢻ㹼
୍⯡♫ᅋἲே㒆ᒣ་ᖌ఍ࠊ㒆ᒣᕷࠊ2015.1.31
― 146 ―
ᮏ⏣⨾࿴Ꮚ
ࡸࡉࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡࣭࣐ࣘࢽࢳ࣮ࣗࢻ®
኱⏣༊୕་ᖌ఍ㄆ▱⑕◊✲఍ ༊Ẹබ㛤ㅮᗙ ୺ദ㸸኱⏣༊୕་ᖌ఍ㄆ▱⑕◊✲఍ ඹ
ദ㸸኱⏣༊࣭኱᳃་ᖌ఍࣭ⵦ⏣་ᖌ఍࣭⏣ᅬㄪᕸ་ᖌ఍ࠊ኱⏣༊ࠊ2015.1.24
ᮏ⏣⨾࿴ᏊࠊYves Gineste
ࡸࡉࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㹼࣐ࣘࢽࢳ࣮ࣗࢻ㹼
NPO ἲே ୰✵▱࣭ᆅᇦ࡛ㄆ▱⑕ࢆᨭ࠼ࡿ఍ࠊ◁ᕝᕷࠊ2015.2.6
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉఏ࠼ࡿ ࢣ࢔ᢏ⾡㸸ࠕ࣐ࣘࢽࢳ࣮ࣗࢻࠖ๰ጞ⪅ㅮ₇఍㹼▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿ
ໟᣓⓗࢥ࣑ࣗࢽࢣ࣮ࢩ࣭ࣙࣥࢣ࢔ᢏἲ㹼
㔠ἑ་⛉኱Ꮫ⑓㝔 ㅮ₇఍ࠊἙ໭㒆ࠊ2015.2.13
ᮏ⏣⨾࿴ᏊࠊYves Gineste
࣐ࣘࢽࢳ࣮ࣗࢻ≉ูㅮ₇
኱㜰ᗓಖ೺⚟♴ᑓ㛛Ꮫᰯ ➨㸯ᅇ་⒪࣭⚟♴ᆅᇦ㐃ᦠ◊✲኱఍ࠊ኱㜰ᕷࠊ2015.2.21
ᮏ⏣⨾࿴Ꮚ
(≉ูㅮ₇) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㸸࣐ࣘࢽࢳ࣮ࣗࢻ
➨ 7 ᅇ ༊ᮾ㒊࣭ᮾ໭㒊ࣈࣟࢵࢡᏛ⾡㞟఍ බ┈♫ᅋἲே ᮾி㒔⌮Ꮫ⒪ἲኈ༠఍༊ᮾ
㒊࣭ᮾ໭㒊ࣈࣟࢵࢡ୺ദࠊỤᮾ༊ࠊ2015.2.22
ᮏ⏣⨾࿴ᏊࠊYves Ginesteࠊ௚᐀ᙧึᯞࠊ㐲⸨῟Ꮚࠊ㤶ᒣኊኴࠊ▼ᕝ⩧࿃ࠊఀᮾ⨾⥴
ᕷẸබ㛤ㅮᗙ ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㸸࣐ࣘࢽࢳ࣮ࣗࢻ®
࣐ࣘࢽࢳ࣮ࣗࢻᕷẸබ㛤ㅮᗙ ⏕Ꮡ⛉Ꮫ◊✲ᡤຓᡂࠊ༓௦⏣༊ࠊ2015.2.22
ᮏ⏣⨾࿴ᏊࠊYves Ginesteࠊఀᮾ⨾⥴
࣐ࣘࢽࢳ࣮ࣗࢻ◊ಟ఍
㞃ᒱᗈᇦ㐃ྜ❧ 㞃ᒱᓥ๓⑓㝔ࠊ㞃ᒱ㒆ࠊ2015.2.23-5
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆࡘࡓ࠼ࡿᢏ⾡㸸㧗㱋⪅ࢣ࢔࣓ࢯࢵࢻ࣐ࣘࢽࢳ࣮ࣗࢻ
᫂἞ࢼ࣮ࢫࢭ࣑ࢼ࣮ࠊ༤ከᕷࠊ2015.3.1
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᒾᡭ┴⮫ᗋ◊ಟ་ྜྠ࢚࢜ࣜࣥࢸ࣮ࢩࣙࣥࠊඵᖭᖹᕷࠊ2015.4.10
― 147 ―
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⦕ࢆࡴࡍࡪ఍ ࢩ࣏ࣥࢪ࣒࢘ࠊ༓௦⏣༊ࠊ2015.4.18
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⪁ᖺ⑓◊✲ᡤ㝃ᒓ⑓㝔ㄆ▱⑕⑌ᝈ་⒪ࢭࣥࢱ࣮ㅮ₇఍ࠊ๓ᶫᕷࠊ2015.5.31
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ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㸸࣐ࣘࢽࢳ࣮ࣗࢻ®ࡢ⌮ᛕ࡜ᢏ⾡
⩌㤿ㄆ▱⑕࢔࢝ࢹ࣑࣮➨ 10 ᅇ᫓ࡢ◊ಟ఍ࠊ๓ᶫᕷࠊ2015.5.31
ᮏ⏣⨾࿴Ꮚ
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㒆ᒣ་ᖌ఍ࠊ㒆ᒣᕷࠊ2015.6.5
ᮏ⏣⨾࿴Ꮚࠊᯘ⣪⨾
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ® ᛴᛶᮇ⑓㝔࡟࠾ࡅࡿㄆ▱⑕ࢣ࢔ࡢᐇ㊶
➨ 73 ᅇᮾி㒔་ᖌ఍෸┳ㆤᖌ༞ᚋᩍ⫱ㅮ⩦఍ࠊᩥி༊ࠊ2015.6.7
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࣐ࣘࢽࢳ࣮ࣗࢻ®ධ㛛
ᖹᡂ 27 ᖺᗘឡ▱┴┳ㆤ⟶⌮◊✲఍ࠊྡྂᒇᕷࠊ2015.6.20
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ᖹᡂ 27 ᖺㄆ▱⑕㧗㱋⪅◊ಟࠊ኱㜰ᗓ┳ㆤ༠఍ࠊ኱㜰ᕷࠊ2015.6.21
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ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
♫఍⚟♴ἲேᜠ㈷㈈ᅋ ῭⏕఍⇃ᮏ⑓㝔ࠊ⇃ᮏᕷࠊ2015.6.24
ᮏ⏣⨾࿴Ꮚ
(බ㛤ㅮᗙ) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®ࡢᐇ㊶
➨ 25 ᅇ᪥ᮏ⢭⚄ಖ೺┳ㆤᏛ఍ බ㛤ㅮᗙࠊࡘࡃࡤᕷࠊ2015.6.27
ᮏ⏣⨾࿴ᏊࠊYves Gineste
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᖹᡂ 27 ᖺᗘ ➨ 7 ᅇ 㔩▼་ᖌ఍Ꮫ⾡ㅮ₇఍ࠊ㔩▼ᕷࠊ2015.6.29
― 148 ―
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᒾᡭ┴❧୰㒊⑓㝔ࠊ໭ୖᕷࠊ2015.6.30
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
῭⏕఍⇃ᮏ⑓㝔ࠊ⇃ᮏᕷࠊ2015.7.9
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®ࡢᐇ㊶
་⒪ἲே♫ᅋ㧗㍯఍ゼၥ⥲఍ࠊရᕝ༊ࠊ2015.7.21
ᮏ⏣⨾࿴Ꮚ
(ࢩ࣏ࣥࢪ࣒࢘) ゐࢀࡿࡇ࡜ࡢព⩏
➨ 4 ᅇ࢚ࣅࢹࣥࢫ࡟ᇶ࡙ࡃ⤫ྜ་⒪◊✲఍ࠊ኱㜰ᕷࠊ2015.8.1
ᮏ⏣⨾࿴ᏊࠊYves Gineste
࣐ࣘࢽࢳ࣮ࣗࢻ࡟ࡘ࠸࡚
኱㜰ᗓ❧⢭⚄་⒪ࢭࣥࢱ࣮ࠕ೺ᗣ་⒪㒔ᕷࡦࡽ࠿ࡓࢥࣥࢯ࣮ࢩ࢔࣒ࠖ㐃ᦠ஦ᴗㅮ₇఍ࠊ
∾᪉ᕷࠊ2015.8.2
ᮏ⏣⨾࿴Ꮚ
(ᩍဨ◊ಟ఍≉ูㅮ₇) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
➨ 46 ᅇ ୰ᅄ஑ᆅ༊་ᖌ఍┳ㆤ༠㆟఍ࠊูᗓᕷࠊ2015.8.23
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
኱ศ┴ಖ೺་ᖌ఍ࠊ኱ศᕷࠊ2015.8.24
ᮏ⏣⨾࿴Ꮚ
࣐ࣘࢽࢳ࣮ࣗࢻ®࡟ࡘ࠸࡚
බ┈♫ᅋἲே ㇏ᓥ༊་ᖌ఍ࠊ㇏ᓥ༊ࠊ2015.9.5
ᮏ⏣⨾࿴Ꮚ
࣐ࣘࢽࢳ࣮ࣗࢻ® ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡
ᮾி་⛉ṑ⛉኱Ꮫ་Ꮫ㒊㝃ᒓ⑓㝔ࠊᩥி༊ࠊ2015.9.10
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᓊ࿴⏣ᕷẸ⑓㝔 㝔ෆ◊ಟ఍ࠊᓊ࿴⏣ᕷࠊ2015.9.11
― 149 ―
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®ࡢᐇ㊶
➨ 46 ᅇ᪥ᮏ┳ㆤᏛ఍(ᅾᏯ┳ㆤ)ࠊྡྂᒇᕷࠊ2015.10.3
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᶓ὾≉ูᨭ᥼ᩍ⫱◊ಟ ᶓ὾ᕷᩍ⫱ጤဨ఍ࠊᶓ὾ᕷࠊ2015.10.9
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
࣐ࣘࢽࢳ࣮ࣗࢻ® ࡑࡢேࡽࡋࡉࢆᅇ᚟ࡉࡏࡿࢣ࢔ᢏ⾡
ᅜ❧⑓㝔ᶵᵓ⇃ᮏ་⒪ࢭࣥࢱ࣮ࠊ⇃ᮏᕷࠊ2015.10.14
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
᯽ᓮᕷส⩚㒆་ᖌ఍ ᯽ᓮส⩚ࢣ࢔◊✲఍ㅮ₇఍ࠊ᯽ᓮᕷࠊ2015.10.20
ᮏ⏣⨾࿴Ꮚ
࣐ࣘࢽࢳ࣮ࣗࢻ®㹼ඃࡋࡉࢆఏ࠼ࡿㄆ▱⑕ࢣ࢔ᢏ⾡㹼
ㄪᕸᮾᒣ⑓㝔 ➨ 89 ᅇ࡜࠺ࡊࢇ⏕ά⩦័⑓ᩍᐊࠊㄪᕸᕷࠊ2015.10.31
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᗈᓥᩥ໬Ꮫᅬ኱Ꮫ ┳ㆤᏛ㒊ࠊ࿋ᕷࠊ2015.11.22
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ᖹᡂ 27 ᖺᗘ㍍⡿⏫ࣇ࢛࣮࣒ࣛࠊ஑ᡞ㒆ࠊ2015.11.23
ᮏ⏣⨾࿴Ꮚ
(グᛕㅮ₇) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
඲ᅜಶูࣘࢽࢵࢺᆺ᪋タ᥎㐍༠㆟఍ ➨㸷ᅇ඲ᅜ◊ಟ኱఍ in ᐑᇛ࣭௝ྎ 2015㹼་⒪
࡜௓ㆤࢆ㐃ᦠࡍࡿ⤫ྜຊ㹼ࠊ௝ྎᕷࠊ2015.11.25
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚࠊᯘ⣪⨾ࠊ᳃㇂㤶Ꮚ
(ᩍ⫱ࢭ࣑ࢼ࣮) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
➨ 13 ᅇᅜ❧⑓㝔┳ㆤ◊✲Ꮫ఍Ꮫ⾡㞟఍ࠊ༓ⴥᕷࠊ2015.11.28
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
➨ 2 ᅇឿᜨ་኱᯽⑓㝔 ⥲ྜデ⒪ࢭ࣑ࢼ࣮ࠊ᯽ᕷࠊ2015.12.2
― 150 ―
[ ◊ಟ ]
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 1 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.1.10-11
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 2 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.2.2-3
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 3 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.5.26-27
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 1 ᅇ᪋タᑟධ‽ഛࢥ࣮ࢫ 10 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.3.2-6
4.14-16 5.28-29
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 4 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.7.18-19
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 5 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.9.22-23
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 6 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.10.10-11
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 2 ᅇ᪋タᑟධ‽ഛࢥ࣮ࢫ 10 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.8.31-9.4
10.6-8 11.5-6
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 7 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.11.19-20
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
࣐ࣘࢽࢳ࣮ࣗࢻ®◊ಟ ➨ 8 ᅇධ㛛ࢥ࣮ࢫ 2 ᪥㛫
ᮾி་⒪ࢭࣥࢱ࣮ ࢹࢪࢱࣝࢭࣥࢭ࣮ࢩࣙࣥᰴᘧ఍♫ࠊ┠㯮༊ࠊ15.12.5-6
― 151 ―
ᮏ⏣⨾࿴Ꮚ
(ゼၥ◊ಟ) ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
㒆ᒣ་ᖌ఍ࠊ㒆ᒣᕷࠊ15.6.5
ᮏ⏣⨾࿴Ꮚࠊ࢖ࣥࢫࢺࣛࢡࢱ࣮┳ㆤᖌ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
඲᪥ᮏ⑓㝔༠఍ㄆ▱⑕◊ಟࠊ༓௦⏣༊ࠊ2015.11.3-4
[ ㅮᖌ ]
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
ㄆ▱⑕ㅮ⩏࣭࣐ࣘࢽࢳ࣮ࣗࢻ
ᮾி་⒪ಖ೺኱Ꮫࠊ┠㯮༊ࠊ2015.1.8
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
ᚰ⌮ࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥᐇ⩦
᪫ᕝ་⛉኱Ꮫ་Ꮫ㒊 1 ᖺ⏕ㅮ⩏ࠊ᪫ᕝᕷࠊ2015.2.7
ᮏ⏣⨾࿴Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
ஂ␃⡿኱Ꮫ་Ꮫ㒊┳ㆤᏛ⛉≉ูㅮ⩏ࠊஂ␃⡿ᕷࠊ2015.6.23
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
ㄆ▱⑕ᝈ⪅࡜ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ
⪷㊰ຍᅜ㝿኱Ꮫᩍ⫱ࢭࣥࢱ࣮஦ᴗ ㄆᐃ┳ㆤᖌᩍ⫱ㄢ⛬(ㄆ▱⑕┳ㆤࢥ࣮ࢫ)ࠊ୰ኸ༊ࠊ
2015.7.3
ᮏ⏣⨾࿴Ꮚࠊ┒┿▱Ꮚ
ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡:࣐ࣘࢽࢳ࣮ࣗࢻ®
᪫ᕝ་⛉኱Ꮫ་Ꮫ㒊 1 ᖺ⏕ㅮ⩏ࠊ᪫ᕝᕷࠊ2015.12.7
[ ࡑࡢ௚ ]
ᮏ⏣⨾࿴Ꮚࠊ᐀ീ೔Ꮚ
(࣓ࢹ࢕࢔) ࢣ࢔ࢆᥦ౪ࡍࡿ“ඃࡋࡉ”ࢆ⾲ࡍࡇ࡜ࡢ࡛ࡁࡿ࣐ࣘࢽࢳ࣮ࣗࢻࡢྍ⬟ᛶ
┳ㆤ ⮫᫬ቑหྕ 2015 ᖺ 3 ᭶ 67(4)㸸92ࠊ᪥ᮏ┳ㆤ༠఍ฟ∧఍ࠊ2015.3.15
ᮏ⏣⨾࿴ᏊࠊYves Ginesteࠊఀᮾ⨾⥴ࠊ➉ᯘὒ୍ࠊ㓇㇂⸅ࠊୖ㔝⚽ᶞࠊᒣཱྀᬕಖࠊ⏣୰ᚿᏊ
(࣓ࢹ࢕࢔) ≉㞟 ࣐ࣘࢽࢳ࣮ࣗࢻࡣఱࡀ㐪࠺࠿Ϩࡑࡢ᭷ຠᛶ࡜ྍ⬟ᛶ
ᅾᏯ࣭ᆅᇦ࡛ࡇࡇࡲ࡛࡛ࡁࡿ㸟ゼၥ┳ㆤ࡜௓ㆤ 2015 ᖺ 4 ᭶ྕ 20㸦4㸧226㸸275-302ࠊ
་Ꮫ᭩㝔ࠊ2015.4
― 152 ―
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ඃࡋࡉఏ࠼ࡿᢏ⾡ ᙺ❧ࡘㄆ▱⑕᪂ࢣ࢔ ࣇࣛࣥࢫ࡛⪃᱌ࠕ࣐ࣘࢽࢳ࣮ࣗ
ࢻࠖ
᪥ᮏ㎰ᴗ᪂⪺ 2015 ᖺ 4 ᭶ 16 ᪥ࠊᰴᘧ఍♫᪥ᮏ㎰ᴗ᪂⪺ࠊ2015.4.16
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ᚰ࡜య࡟ᐤࡾῧ࠺ ㄆ▱⑕ࢣ࢔ࡢᢏἲ
NHK ࢸࣞࣅࢸ࢟ࢫࢺ ࡁࡻ࠺ࡢ೺ᗣ 2015 ᖺ 5 ᭶ྕ㸸94-100ࠊNHK ฟ∧ࠊ2015.4.21
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ≉㞟 ࠕே㛫ࡽࡋࡉࢆᑛ㔜ࡍࡿࠖࣇࣛࣥࢫ࡛⏕ࡲࢀࡓࢣ࢔ᢏἲ ࣐ࣘࢽࢳ
࣮ࣗࢻ ࢣ࢔ࢆᚲせ࡜ࡍࡿࡍ࡭࡚ࡢே࡬
UA ࢮࣥࢭࣥ᪥ᮏ௓ㆤࢡࣛࣇࢺࣘࢽ࢜ࣥ(NCCU)ᶵ㛵ㄅ(ᖺ 6 ᅇⓎ⾜) NCCU NEWS
㸦࢚ࢾࢩ࣮ࢩ࣮࣮ࣘ㸧VOL.9 2015.4㸸3-6ࠊUA ࢮࣥࢭࣥ᪥ᮏ௓ㆤࢡࣛࣇࢺࣘࢽ࢜ࣥࠊ
2015.4
ᮏ⏣⨾࿴ᏊࠊYves Ginesteࠊ▼ᆏ⨾༓௦ࠊ┒┿▱Ꮚࠊ᐀ᙧึᯞࠊ㤶ᒣኊኴࠊఀᮾ⨾⥴ࠊ
ᯘ⣪⨾ࠊ୸⸨⏤⣖ࠊᮌᮧὒᏊࠊ⮉⏿ᩔᏊࠊᯇᮧ┿ྖ
(࣓ࢹ࢕࢔) ≉㞟 ࣐ࣘࢽࢳ࣮ࣗࢻࡣఱࡀ㐪࠺࠿ϩᅾᏯ࣭ᆅᇦ࡛ࡢά⏝ྍ⬟ᛶ
ᅾᏯ࣭ᆅᇦ࡛ࡇࡇࡲ࡛࡛ࡁࡿ㸟ゼၥ┳ㆤ࡜௓ㆤ 2015 ᖺ 5 ᭶ྕ 20(5)㸸367-404ࠊ་Ꮫ
᭩㝔ࠊ2015.5.15
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ඃࡋࡉఏ࠼ࡿ ࣇࣛࣥࢫⓎ⚈ ௓ㆤᢏ⾡ ࠕ࣐ࣘࢽࢳ࣮ࣗࢻࠖ
ᅄࡘࡢᇶᮏ
᪥ᮏ㎰ᴗ᪂⪺ 2015 ᖺ 5 ᭶ 28 ᪥ࠊᰴᘧ఍♫᪥ᮏ㎰ᴗ᪂⪺ࠊ2015.5.28
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ㄆ▱⑕ࢣ࢔ࢆゎㄝ 㒆ᒣᕷ་⒪௓ㆤ⑓㝔 9 ࿘ᖺㅮᗙ
⚟ᓥẸሗ 2015 ᖺ 6 ᭶ 5 ᪥ࠊ⚟ᓥẸሗ♫ࠊ2015.6.5
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ࣇࣛࣥࢫࡢㄆ▱⑕ࢣ࢔ ࣐ࣘࢽࢳ࣮ࣗࢻ⤂௓
⚟ᓥẸ཭ HOMETOWN 㒆ᒣ࣡࢖ࢻ 2015 ᖺ 6 ᭶ 5 ᪥ࠊ⚟ᓥẸ཭᪂⪺♫ࠊ2015.6.5
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ␗ᴗ✀ࡢᗈሙ ௙஦ே┤ᧁ࢖ࣥࢱࣅ࣮ࣗ ᮏ⏣⨾࿴Ꮚࡉࢇ
ᑠභᩍ⫱ᢏ⾡ 2015 ᖺ 7/8 ᭶ྕ 68(4)㸸46-49ࠊᑠᏛ㤋ࠊ2015.7
― 153 ―
ᮏ⏣⨾࿴ᏊࠊYves Gineste
(࣓ࢹ࢕࢔) ᖹᡂ 27 ᖺᗘ ➨ 7 ᅇ㔩▼་ᖌ఍Ꮫ⾡ㅮ₇఍ ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡㸸
࣐ࣘࢽࢳ࣮ࣗࢻ㹼ࡑࡢᇶᮏ࡜ᐇ㊶㹼
㔩▼་ᖌ఍ሗ ᖹᡂ 27 ᖺ 8 ᭶ྕ No.319㸸15-16ࠊ㔩▼་ᖌ఍ࠊ2015.8
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ࣐ࣘࢽࢳ࣮ࣗࢻࡣ࡝ࢇ࡞ࢣ࢔?
NHK ࠶ࡉ࢖ࢳ࣐࢞ࢪࣥ vol.12㸸33ࠊᐆᓥ♫ࠊ2015.9.15
ᮏ⏣⨾࿴ᏊࠊYves Gineste
(࣓ࢹ࢕࢔) ࢢࣛࣇ D ࢝ࣇ࢙ࡢ㢼ᬒࠕࢧࣉࣛ࢖ࢬ㸟ㅦࡢࣇࣛࣥࢫே⌧ࢀࡿࠖ
௓ㆤ⪅ࡀࡘࡃࡿㄆ▱⑕᝟ሗㄅ ࡛࠷ࡵࢇࡋ࠶ No.3 㸸18ࠊ≉ᐃ㠀Ⴀ฼άືἲே
D ࢝ࣇ࢙ࡲࡕ࡙ࡃࡾࢿࢵࢺ࣮࣡ࢡࠊ2015.9.15
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) column ㄆ▱⑕௓ㆤࡀᴦே࡞ࡿ࡜ヰ㢟“࣐ࣘࢽࢳ࣮ࣗࢻ”࡜ࡣ㸽
Adviser ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ ⥲ྜෆ⛉་㛗ᮏ⏣⨾࿴Ꮚࡉࢇ
᪥⤒࠾࡜࡞ࡢ OFF 2015 ᖺ 10 ᭶ྕ⮫᫬ቑห㸸47ࠊ᪥⤒ BP ♫ࠊ2015.9.16
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ே㛫ࡢᑛཝࢆ኱ษ࡟ࡍࡿㄆ▱⑕ࢣ࢔ࠊࠕ࣐ࣘࢽࢳ࣮ࣗࢻࠖࢆ᪥ᮏ࡟
SPUR(ࢩࣗࣉ࣮ࣝ)11 ᭶ྕ㸸364ࠊ㞟ⱥ♫ࠊ2015.9.23
ᮏ⏣⨾࿴Ꮚࠊᯇୗṇ᫂ࠊYves Ginesteࠊఀᮾ⨾⥴ࠊཎᑑኵࠊ᐀ᙧึᯞࠊ㐲⸨῟Ꮚࠊ㤶ᒣኊኴࠊ
▼ᕝ⩧࿃ࠊṊ⏣⣧୕
(࣓ࢹ࢕࢔) ᕷẸබ㛤ㅮᗙ㸻ඃࡋࡉࢆఏ࠼ࡿࢣ࢔ᢏ⾡-࣐ࣘࢽࢳ࣮ࣗࢻ
⏕Ꮡ⛉Ꮫ 2015,9 26(1)㸸127-159ࠊබ┈ಙクṊぢグᛕ⏕Ꮡ⛉Ꮫ◊✲ᇶ㔠බ┈㈈ᅋἲே
⏕Ꮡ⛉Ꮫ◊✲ᡤࠊ2015.9.30
ᮏ⏣⨾࿴ᏊࠊYves Gineste
(࣓ࢹ࢕࢔) ㄡࡶࡀᏛ࡭ࠊᐇ㊶࡛ࡁࡿ࣐ࣘࢽࢳ࣮ࣗࢻࠋ5 ࡘࡢࢫࢸࢵࣉ࡛ᝈ⪅ࡢᚰ࡟
㏆࡙ࡃ
HELPMAN JAPANࠊ2015.10.16
ᮏ⏣⨾࿴Ꮚ
(࣓ࢹ࢕࢔) ㄆ▱⑕་⒪ࡣ࢟ࣗ࢔ࡼࡾࢣ࢔ ✜ࡸ࠿࡟వ⏕ࢆ㐣ࡈࡍࡓࡵ࡟
࣐ࣘࢽࢳ࣮ࣗࢻࢆᑟධ
AERA 2015 ᖺ 11 ᭶ 2 ᪥ྕ 28(47)㸸26-27ࠊᮅ᪥᪂⪺ฟ∧ࠊ2015.10.26
― 154 ―
་⒪⤒Ⴀ᝟ሗ◊✲ᐊ
[ ㄽᩥ ]
Nakatomi H, Miyazaki H, Tanaka M, Kin T, Yoshino M, Oyama H, Usami M,
Moriyama H, Kojima H, Kaga K, Saito N
Improved preservation of function during acoustic neuroma surgery
Journal of Nuerosurgery 122(1):24-33, 2015.1
impact factor
3.227
Zhang Q, Xu X, Xu M, Hu J, Liang J, Kaga K
Ocular and cervical vestibular evoked myogenic potentials in patients with
peripheral vestibular disorders
Journal of Clinical Otorhinolaryngology, Head & Neck Surgery (Chinese)
29(2):147-151, 2015.1
impact factor
0.00
Kaga K, Shinjo Y, Enomoto C, Sindo M
A case of cortical deafness and loss of vestibular and somatosensory sensations
caused by cerebrovascular lesions in bilateral primary auditory cortices, auditory
radiations, and postcentral gyruses-complete loss of hearing despite normal DPOAE
and ABR
Acta Oto-Laryngologica 135(4):389-394, 2015.4
impact factor
1.099
Ọ஭㑈ᩯࠊ༡ಟྖ㑻ࠊ኱཭❶Ꮚࠊᴮᮏ༓ỤᏊࠊ⸨஭ṇேࠊຍᡃྩᏕ
┣⫏ࡢ㧗㱋⪅࡟ᑐࡍࡿேᕤෆ⪥⾡ᚋࡢ⫈ぬ෌⋓ᚓ࡜ QOL
⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ 83(2):165-167, 2015.2
኱཭❶Ꮚࠊ༡ಟྖ㑻ࠊỌ஭㑈ᩯࠊᯇỌ㐩㞝ࠊᴮᮏ༓ỤᏊࠊᆏ⏣ⱥ᫂ࠊ⸨஭ṇேࠊຍᡃྩᏕ
Waardenburg ⑕ೃ⩌ 2 ᆺ࡟ᑐࡍࡿேᕤෆ⪥ᇙࡵ㎸ࡳ⾡ᚋࡢ⫈ぬ࣭ゝㄒⓎ㐩
⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ 83(2):173-175, 2015.2
[ ⥲ㄝ ]
ຍᡃྩᏕ
(୍㐌୍ㄒ)┣⫏஧㔜㞀ᐖ࡟ᑐࡍࡿேᕤෆ⪥ᡭ⾡Ɇ෌ࡧ⪺࠸࡚ヰࡍ႐ࡧ
᪥ᮏ་஦᪂ሗ No.4734ࠊp53ࠊ2015.1
ຍᡃྩᏕ
ࢫࢺࣞࢫ࡜ࡣఱ࠿㸽
JOHNS 31(3):269-271ࠊ2015.3
― 155 ―
ຍᡃྩᏕ
ࢫ࣏࣮ࢶ࡜ᖹ⾮ᶵ⬟㸦୕༙つ⟶࣭⪥▼ჾࡢᙺ๭㸧㹼ጼໃ཯ᑕ vs. 㝶ព㐠ື㹼
᪥ᮏ⮫ᗋࢫ࣏࣮ࢶ་Ꮫ఍ㄅ 23(2):198-200ࠊ2015.4
ຍᡃྩᏕ
୰ᯡᛶ㢦㠃⚄⤒㯞⑷ࢆぢ㏨ࡉ࡞࠸ࢥࢶ
JOHNS 31(6):711-715ࠊ2015.6
ຍᡃྩᏕ
Auditory Neuropathy㸦ᡂேᆺ㸧࡟ᑐࡍࡿேᕤෆ⪥ᡭ⾡࡟ࡼࡿ⫈ぬࡢ෌⋓ᚓ
ENTONI No.181㸸61-67ࠊ2015.6
ᴮᮏ༓ỤᏊࠊຍᡃྩᏕ
┣ࢁ࠺⪅࡟ᑐࡍࡿேᕤෆ⪥ࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ
ENTONI No.181㸸68-71ࠊ2015.6
ຍᡃྩᏕ
AN ࡜ ANSD
JOHNS 31(11):1601-1606ࠊ2015.11
㐍⸨⨾ὠᏊࠊຍᡃྩᏕ
⫈ぬኻㄆ࡜⓶㉁⫏
JOHNS
31(11):1607-1611ࠊ2015.11
ຍᡃྩᏕ
ኻ㡢ᴦ࡜⬻ࡢᒁᅾᛶ࠾ࡼࡧ㡢ᴦ࡜ேᕤෆ⪥
JOHNS 31(11):1612-1618ࠊ2015.11
ຍᡃྩᏕࠊቑ⏣Ẏ
ᑠඣࡢ๓ᗞᶵ⬟ࡢ㞀ᐖ࡜Ⓨ㐩Ɇඛኳᛶ㞴⫈ඣࡢ๓ᗞ༙つ⟶㞀ᐖࡢ㐠ືⓎ㐩࡟ཬࡰࡍ
ᙳ㡪࡟ࡘ࠸࡚Ɇ
ᑠඣ⪥㰯ဗႃ⛉ 36(3):251-258ࠊ2015.12
ຍᡃྩᏕ
Sensory deprivation ࡜ࡋ࡚ࡢ⫈ぬ㞀ᐖɆேᕤෆ⪥࠿ࡽぢࡓ⫈ぬࡢྍረᛶɆ
ㄆ▱⚄⤒⛉Ꮫ 217(3,4):113-117ࠊ2015.12
― 156 ―
[ ⴭ᭩ ]
ຍᡃྩᏕࠊ୰ᮧ㞞Ꮚ
⫈ぬࡢᶵ⬟పୗɆ㉸㧗㱋ᮇࡢ㞴⫈࠾ࡼࡧ┣⫏஧㔜㞀ᐖ࡜ேᕤෆ⪥
㧗㱋⪅ࡢ୙Ᏻ࡜ࡑࡢᑐ⟇Ɇ⤒῭࣭೺ᗣ࣭Ꮩ⊂ࠊpp.97-105
බ┈㈈ᅋἲே 㛗ᑑ⛉Ꮫ᣺⯆㈈ᅋࠊ2015.3
ຍᡃྩᏕࠊᒣ୰᪼⦅
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪ Q&A. Ϩᕳ
඲᪥ᮏ⑓㝔ฟ∧఍ 2015.4
ᒣ୰᪼ࠊຍᡃྩᏕ⦅
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪ Q&A. ϩᕳ
඲᪥ᮏ⑓㝔ฟ∧఍ 2015.4
ຍᡃྩᏕ
➨ 15 ❶⪥㰯ဗႃ⛉ࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ࡜┳ㆤ 1.ඛኳᛶ㞴⫈ඣࡢࣜࣁࣅࣜࢸ࣮ࢩࣙࣥ ࡜┳ㆤ
⪥㰯ဗႃ⛉࢚࢟ࢫࣃ࣮ࢺࢼ࣮ࢩࣥࢢ ᨵゞ➨ 2 ∧ࠊ᳃ᒣᐶ࣭ᑠᓥ༤ᕫ⦅ࠊpp.481-484ࠊ
༡Ụᇽࠊ2015
[ Ꮫ఍Ⓨ⾲ ]
ຍᡃྩᏕࠊᯇỌ㐩㞝ࠊᮅᡞ⿱㈗
୧ഃᑠ⪥⑕㸦እ⪥ወᙧ㸧
࣭እ⪥㐨㛢㙐⑕
ᖹᡂ 26 ᖺᗘཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠㞴἞ᛶ⑌ᝈ➼ඞ᭹◊✲஦ᴗࠕ㞴἞ᛶ⫈ぬ㞀ᐖ࡟ 㛵ࡍࡿㄪᰝ◊✲⌜ࠖ◊✲ᡂᯝሗ࿌఍ࠊ2015.2.15 ရᕝ༊
ᮌᮧඃ௓ࠊቑ⏣ẎࠊຍᡃྩᏕ
Cochlear nerve deficiency ࡢ 4 ౛ࡢ㐠ືᶵ⬟Ⓨ㐩
➨ 206 ᅇ᪥⪥㰯ᮾி㒔ᆅ᪉㒊఍ࠊ2015.3.14 ᪂ᐟ༊
Kitamura M, Minami S, Matsunaga T, Masuda T, Enomoto C, Kaga K
Cochlear implantation in a patient with Adult-onset auditory neuropathy
10th Asia Pacific Symposium on Cochlear Implantࠊ2015.5.2 Beijing
Enomoto C, Minami S, Kitamura M, Kaga K
The efficacy of cochelar implantation and intraoperatvie measurement of NRT and
EABR in deaf-blind subjects
XXIV Biennial symposium of International Evoked Response Audiometry Study
Groupࠊ2015.5.10-14, Busan
― 157 ―
ຍᡃྩᏕࠊ༡ಟྖ㑻ࠊ᪂ṇ⏤⣖Ꮚ
㧗㱋┣⫏஧㔜㞀ᐖࡢ 1 ౛࡟ᑐࡍࡿ୧ഃேᕤෆ⪥ᡭ⾡࡟ࡼࡿ QOL ࡢኚ໬
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊ2015.5.21 ༓௦⏣༊ ᪂ṇ⏤⣖Ꮚࠊ༡ಟྖ㑻ࠊຍᡃྩᏕ
Wolfram ⑕ೃ⩌࡟ࡼࡿどぬ㞀ᐖྜేᑠඣ⑕౛ࡢ୧ഃேᕤෆ⪥ᇙ㎸⾡ᚋࡢ QOL ࡢᨵၿ
࡟ࡘ࠸࡚
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊ2015.5.21 ༓௦⏣༊ ᮌᮧඃ௓ࠊቑ⏣ẎࠊຍᡃྩᏕ
ෆ⪥ወᙧ Common cavity6 ౛ࡢ㐠ືᶵ⬟Ⓨ㐩Ɇ୍᪉ྥῶ⾶ᅇ㌿᳔Ꮚ᳨ᰝ࡟ࡼࡿ๓ᗞᶵ
⬟࡜ࡢ㛵ಀ࡟ࡘ࠸࡚Ɇ
➨ 208 ᅇ᪥⪥㰯ᮾி㒔ᆅ᪉㒊఍ࠊ2015.7.18
Kaga K, Asato H
Sound lateraziation test in patients with unilateral microtia and atresia after
reconstuction surgery of the auricle and external canal and fitting of a canal-tiyp
hearing aids
2015 Annual CORLAS Meetingࠊ2015.8.25
San Francisco
ෆᒣຮࠊᚨග⿱Ꮚࠊ㯮ᮌ೔Ꮚࠊኳ㐨ᩥᏊࠊᴋᒃ⿱Ꮚࠊఀ㞟㝔ுᏊࠊຍᡃྩᏕ
ேᕤෆ⪥⿦⏝ඣࡢ᪩ᮇ⒪⫱ຠᯝ࡟ࡘ࠸࡚
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍ࠊ2015.10.23 ᪂ᐟ༊
ᮌᮧඃ௓ࠊቑ⏣Ẏࠊ༡ಟྖ㑻ࠊຍᡃྩᏕ
Common cavityࠊcochlear nerve deficiency ࡢࣂࣛࣥࢫᶵ⬟Ⓨ㐩ࡢẚ㍑
➨ 74 ᅇ᪥ᮏࡵࡲ࠸ᖹ⾮་Ꮫ఍⥲఍ࠊ2015.11.26 ᒱ㜧ᕷ
[ ㅮ₇ ]
ຍᡃྩᏕ
∦ഃᑠ⪥⑕࣭እ⪥㐨㛢㙐⑕࡜⾡ᚋࡢ⿵⫈ჾ⿦⏝࡟ࡼࡿࠊ୧᪉ࡢ⪥࡛⫈ࡃ
➨ 10 ᅇ㟷✵ࡢ఍ࠊ➨㸷ᅇ TC ࡢ఍ࠊ2015.1.18 ༓௦⏣༊
ຍᡃྩᏕ
࿡ぬࢆឤࡌࡿ⯉ࡢ࿡ⷣ࡜⬻ࡢࡋࡃࡳ
ᮾிಖ೺་⒪኱Ꮫୡ⏣㇂࢟ࣕࣥࣃࢫㅮ⩏ࠕ་⒪ᰤ㣴Ꮫᴫㄽϩࠖࠊ2015.1.20 ୡ⏣㇂༊
ຍᡃྩᏕ
᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢࠊᚋ㏞㊰ᛶ㞴⫈ࡢ᳨ᰝɆ୰ᯡᛶ⫈ぬ㞀ᐖ⑕౛ࡢᫎീ⤂௓
ᖹᡂ 27 ᖺᗘ⫈ຊ ᐃᢏ⾡ㅮ⩦఍ ➨ 19 ᅇ⫈ぬ་Ꮫ࣭་ᖌㅮ⩦఍ 2015.2.13 ရᕝ༊
― 158 ―
ຍᡃྩᏕ
୰ᯡ⫈ぬࡢࡋࡃࡳ࡜⫈ぬㄆ▱㞀ᐖ
⟃Ἴ኱Ꮫ኱Ꮫ㝔ே㛫⥲ྜ⛉Ꮫ◊✲⛉ ឤᛶㄆ▱⬻⛉Ꮫᑓᨷࠕឤᛶㄆ▱⬻⛉Ꮫᇶ♏ㄽ 2ࠖ
2015.2.20 ࡘࡃࡤᕷ
ຍᡃྩᏕ
AN ࡜ ANSD ࡢ⣽ศ㢮
ᖹᡂ 26 ᖺᗘཌ⏕ປാ⛉Ꮫ◊✲ጤク㈝㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲㛤Ⓨጤク㈝㸦ឤぬჾ㞀ᐖศ
㔝㸧ࠕ᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡟࠾ࡅࡿ Auditory Neuropathy Spectrum Disorders
⑕౛ࡢ㛗ᮇ㏣㊧◊✲ࠖ⌜ ⌜఍㆟ 2015.3.1ࠊ┠㯮༊
ຍᡃྩᏕࠊቑ⏣Ẏࠊᮌᮧඃ௓ࠊ⸆ᖌ୸௧Ꮚࠊ୰ᮧ㞞Ꮚ
୰ᅜࡢྎ㐃࠿ࡽࡁࡓ AN ࡢ୰Ꮫ 1 ᖺ⏕ዪᏊ
ᖹᡂ 26 ᖺᗘཌ⏕ປാ⛉Ꮫ◊✲ጤク㈝㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲㛤Ⓨጤク㈝㸦ឤぬჾ㞀ᐖศ
㔝㸧ࠕ᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡟࠾ࡅࡿ Auditory Neuropathy Spectrum Disorders
⑕౛ࡢ㛗ᮇ㏣㊧◊✲ࠖ⌜఍㆟ 2015.3.1ࠊ┠㯮༊
ຍᡃྩᏕ
80㹼90 ṓ௦ࡢேᕤෆ⪥࡟ࡼࡿ⫈ぬࡢ෌⋓ᚓ
ཌປ┬⛉Ꮫ◊✲㈝⿵ຓ㔠㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲஦ᴗ◊✲ᡂᯝⓎ⾲఍㸦୍⯡ྥࡅ㸧
➨ 10 ᅇᕷẸබ㛤ㅮᗙ㸦⫈ぬ㞀ᐖࢩ࣮ࣜࢬ㸧ᗂᑠඣ࡜ᡂே㧗㱋⪅ࡢ㞴⫈࡜ேᕤෆ⪥ࡢ᪂
ࡋ࠸ືࡁ 2015.3.27ࠊ┠㯮༊
Kaga K, Masuda T, Minami S
Significant of rotational chair vestibular test for pediatric cochlear implant
candidates
10th Asia Pacific Symposium on Cochlear Implant 2015.5.2ࠊBeijing
ຍᡃྩᏕ
ᩍ⫱ࢭ࣑ࢼ࣮4㸬ᑠඣࡢ๓ᗞᶵ⬟ࡢ㞀ᐖ࡜Ⓨ㐩Ɇඛኳᛶ㞴⫈ඣࡢ๓ᗞ༙つ⟶㞀ᐖࡢ㐠ື
Ⓨ㐩࡟ཬࡰࡍᙳ㡪
➨ 10 ᅇ᪥ᮏᑠඣ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ 2015.5.8ࠊ㍍஭ἑ
ຍᡃྩᏕ
ࢃࡀᅜࡢ᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢࡢග࡜ᙳɆㅖእᅜ࡜ࡢẚ㍑Ɇ
ᮾி་⒪ಖ೺኱Ꮫ 㧗ᗘᐇ㊶┳ㆤࢥ࣮ࢫ ࠕᨻ⟇་⒪≉ㄽࠖ 2015.5.22ࠊ┠㯮༊ ຍᡃྩᏕ
ேᕤෆ⪥ࡀྲྀࡾᡠࡍ⫈ぬࡢୡ⏺Ɇᗂඣ࡜㧗㱋⪅Ɇ
ᮾி኱ᏛᕤᏛ㒊 Ꮫ㒊 4 ᖺ⏕࣭኱Ꮫ㝔⏕ྥㅮ⩏ࠕ㔞Ꮚㄽ㸭⏕࿨ㄽࠖ 2014.6.12ࠊᩥி༊
― 159 ―
ຍᡃྩᏕ
᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡜⌧ᅾࡢၥ㢟࡜ㄢ㢟
➨ 60 ᅇឡ▱┴⪥㰯ဗႃ⛉་఍◊ಟ఍㸦ឡ▱┴⪥㰯ဗႃ⛉་఍ᖹᡂ 27 ᖺᗘ◊ಟ఍㸧
2015.6.20ࠊྡྂᒇᕷ
ຍᡃྩᏕ
≉ูㅮ₇㸬Sensory Deprivation ࡜ࡋ࡚ࡢ⫈ぬ㞀ᐖɆேᕤෆ⪥࠿ࡽࡳࡓ⫈ぬࡢྍረᛶ
࠾ࡼࡧ⓶㉁⫏࡟ࡘ࠸࡚
➨ 20 ᅇㄆ▱⚄⤒⛉Ꮫ఍Ꮫ⾡ㅮ₇఍ 2015.8.8ࠊᩥி༊
ຍᡃྩᏕ
ேᕤෆ⪥ᡭ⾡࡟ࡼࡗ࡚ඞ᭹ࡉࢀࡓඛኳᛶ㞴⫈࡜ᚋኳᛶ㞴⫈
㣁⏣་ᏛዡᏛ఍ࠕ10 ᭶ࡢ㞟࠸ࠖ2015.10.3ࠊᩥி༊
ຍᡃྩᏕ
୧⪥⫈ɆDirectional HearingɆ
➨ 2 ᅇ඲ᅜゝㄒ⫈ぬኈ◊ಟ఍ 2015.11.22ࠊ⦎㤿༊
ຍᡃྩᏕ
⥴᪉ὥᗡࡢỤᡞ࡛ࡢᐈṚ࠾ࡼࡧຍ⸨஽ᩍᤵࡢ 1910㹼1912 ࢘࢕࣮ࣥ␃Ꮫ࡜ࡑࡢά㌍ࢆ
ࡵࡄࡗ࡚
➨ 84 ᅇཧ஑఍㸦኱㜰኱Ꮫ⪥㰯ဗႃ⛉࣭㢌እ⛉Ꮫᩍᐊ㸧⥲఍ 2015.11.28ࠊ኱㜰ᕷ
Kaga K
(Keynote Lecture) Historical development of Japan-Taiwan Conference on
Otolaryngology-Head and Neck Surgery
13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
2015.12.3ࠊTokyo
[ࡑࡢ௚]
ຍᡃྩᏕ
㸦ྖ఍㸧⫈ぬ㞀ᐖ࡟࠾ࡅࡿཎᅉ㑇ఏᏊࡢ᪂ࡓ࡞ᒎ㛤
➨ 10 ᅇឤぬჾࢩ࣏ࣥࢪ࣒࢘ 2015.3.6ࠊ┠㯮༊
Kaga K
(Moderator) Changes in cortical resource allocation in hearing loss
XXIV Biennial Symposium of International Evoked Response Auditory Study Group
2015.5.13ࠊBusan
― 160 ―
Kaga K
(Modrator) Round Table 26: Auditory neuropathy and cochlear nerve dificiency
The 30th Politzer Society Meeting
2015.7.3ࠊNiigata
― 161 ―
⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ
[ ㄽᩥ ]
Yajima.A㸪Uesawa.Y㸪Ogawa.C㸪Yatabe.M㸪Kondo.N㸪Saito.S㸪Suzuki.Y,Atsuda.K.㸪
Kagaya.H
Construction Of a Model for Predicting Creatinine Clearance in Japanese Patients
Treated with Cisplatin Therapy
ANTICANCER RESEARCH㸹35㸸2904-2915㸪2015.5
impact factor
1.604
᭷㤿 ⚽ᶞ㸪㏆⸨ ┤ᶞ㸪⏣ᓮ ṇಙ㸪ᑎඖ ๛㸪Ỉ஭ ㈗モ㸪Ώ㑓 㐩ஓ
་⸆ရࣜࢫࢡ⟶⌮ィ⏬࡟ྥࡅࡓ⑓㝔⸆๣ᖌࡢ〇㐀㈍኎ᚋㄪᰝᨭ᥼࡟㛵ࡍࡿ᳨ウ
Journal of Japanese Society of Hospital Pharmacists㸦᪥ᮏ⑓㝔⸆๣ᖌ఍㞧ㄅ㸧㸹
51(10)㸸1163-1168㸪2015.10
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
[ ⥲ㄝ ]
➉ୗ ᬛᜨ㸪┠㯮 ᩥỤ㸪୰ᑿ ㈗Ꮚ㸪ᯇ஭ ࠸࡙ࡳ㸪⩚⏣ ࠿࠾ࡿ㸪ྜྷ஭ ୍ᜨ㸪⋪㡲 ࡉࡘ
ࡁ㸪ஂ㒊 ὒᏊ㸬
Clinical Research Coordinator㸦CRC㸧ࡢ࢟ࣕࣜ࢔㛤Ⓨ࡟ࡴࡅ࡚ࡢ⌧≧࡜ㄢ㢟㸫ࡸࡾ
ࡀ࠸➼ࡢព㆑ㄪᰝ⤖ᯝࡼࡾ
⸆⌮࡜἞⒪㸹43(1)㸸17-20㸬
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
୰ᕝ ⏤⨾
ࠕ➨ 35 ᅇ ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍Ꮫ⾡⥲఍ࠖ࡟ཧຍࡋ࡚㹼ࠕ➨ 3 ḟᆏࡢୖࡢ㞼ࠖ㸪◊✲೔
⌮ᣦ㔪ࡢᨵṇ➼㸪἞㦂ࡢຠ⋡ྥୖࣉࣟࢪ࢙ࢡࢺ
Clinical Research Professionals㸹46㸸34-37
✄ྜྷ ⨾⏤⣖
ACRP 2015 Global Conference ࠾ࡼࡧ⌧ᆅ་⒪ᶵ㛵どᐹձࠕCAPA ࡢᡭἲࢆ⏝࠸ࡓ㐓
⬺෌Ⓨ㜵Ṇ࡟ྥࡅࡓྲྀࡾ⤌ࡳࠖ
Clinical Research Professionals㸹48㸸28-29
✄ྜྷ⨾⏤⣖
ࠕᅜ㝿ඹྠ἞㦂ࡢ⌧≧࡜ᐇ᪋࡟㝿ࡍࡿὀពⅬࠖ
Ᏻᚰฎ᪉ infobox㸦http://anshinshoho.ims-japan.co.jp/㸧ࠖ㸹100㸪2015.7
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
― 162 ―
㏆⸨ ┤ᶞ
ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖࡢゎㄝ
⸆஦᪂ሗ; 2901(2015):817-823㸪2015.7
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
㏆⸨ ┤ᶞ㸪ᒣཱྀ ᣅὒ
◊✲⪅୺ᑟ⮫ᗋヨ㦂ࡢ㉁ࡢྥୖ࡬ࡢ࢔ࣉ࣮ࣟࢳ㸫⮫ᗋ◊✲ࡢಙ㢗ᛶ☜ಖࡢྲྀࡾ⤌ࡳ
ࠕ௻⏬ࡢពᅗ࡜ࡲ࡜ࡵࠖ
Jpn Pharmacol Ther㸦⸆⌮࡜἞⒪㸧㸹43(8)㸸1084㸪2015.8
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
㏆⸨ ┤ᶞ
ࠗ἞㦂࡟ಀࡿ ಖ㝤እే⏝⒪㣴㈝ ゎㄝ࡜ Q㸤A࠘
Journal of Japanese Society of Hospital Pharmacists㸦᪥ᮏ⑓㝔⸆๣ᖌ఍㞧ㄅ㸧㸹
51(11)㸸1359㸪2015.11
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
㏆⸨ ┤ᶞ
ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖࡢ࣏࢖ࣥࢺ࡜␃ពⅬɆ⮫ᗋ◊✲஦
ົᒁ࡜ࡋ࡚ࡢ❧ሙ࠿ࡽɆ㸬Clinical Research Professionals㸹50㸸4-11㸪2015.10
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
➉ୗ ᬛᜨ
➨ 15 ᅇ CRC ࡜⮫ᗋヨ㦂ࡢ࠶ࡾ᪉ࢆ⪃࠼ࡿ఍㆟ 2015ࠖ࡟ཧຍࡋ࡚
Clinical Research Professionals㸹51㸸6-7㸪2015.12
࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ 0.00
[ ⴭ᭩ ]
ఀ⸨ ຾ᙪ㸪ᴋᒸ ⱥ㞝㸪㏆⸨ ┤ᶞ㸪ᒣᮏ ὒ୍㸪ఀ⸨ ⃈ಙ㸪ᒣᮏ Ꮫ㸪ⱝ஭ ಟ἞㸪᳃ୗ
඾Ꮚ㸪✄ྜྷ⨾⏤⣖㸪ᕝᮧ 㝧Ꮚ㸪ᱵᰁ ⣫⨾㸪Ặཎ ῟㸪᭷ἑ ⣖Ꮚ㸬
⮫ᗋ◊✲࣭἞㦂άᛶ໬㸳࠿ᖺィ⏬ 2012 ࡢホ౯࡟ྥࡅࡓ἞㦂࣭⮫ᗋ◊✲ᇶ┙ᩚഛ≧
ἣㄪᰝࡢෆᐜ᳨ウ࡜⤖ᯝ㞟ィ࣭ホ౯
ᖹᡂ 26 ᖺᗘཌ⏕ປാ⛉Ꮫ◊✲ሗ࿌᭩㸬2015.4
[ Ꮫ఍Ⓨ⾲ ]
Miyuki Inayoshi
Implementing CRC education system using Corrective and Preventative Actions
㸦CAPA㸧 System on site
ACRP 2015 Global Conference & Exhibition, Salt Lake City, 20150425
― 163 ―
ᐑᮏ ಇ୍ࠊ㏆⸨ ┤ᶞࠊ⃰἟ ᨻ⨾ࠊᯇᔱ⏤⣖Ꮚࠊ㔝ᮧ ஂ⚈ࠊᒣᓮ୕బᏊࠊΏ㒊 ḷ⧊ࠊ
ஂಖ⏣⠜ྖࠊ ᴮᮏ᭷ᕼᏊ
ᮾி㒔⑓㝔⸆๣ᖌ఍⮫ᗋ◊✲ᑓ㛛⸆๣ᖌ㣴ᡂ≉ูጤဨ఍ࡢάືሗ࿌㸦3 ሗ㸧㸬᪥ᮏ⑓㝔
⸆๣ᖌ఍㛵ᮾࣈࣟࢵࢡ➨ 45 ᅇᏛ⾡኱఍㸪ࡘࡃࡤ㸪2015.8.1㸬
✄ྜྷ ⨾⏤⣖㸪ᮏ ஂ⨾Ꮚ㸪ᔱᒸ ⥳㸪⸨ᕝ ཭Ꮚ㸪㧗ᮌ ᜨ⨾㸪➉ୗ ᬛᜨ㸪▼஭ ཭㔛㸪
㔠ග ❶Ụ㸪୰ᕝ ⏤⨾㸪㏆⸨ ┤ᶞ
Corrective and Preventative Action(CAPA)࡟ࡼࡿ㐓⬺㜵Ṇ࡬ࡢྲྀࡾ⤌ࡳ
➨ 15 ᅇ CRC ࡜⮫ᗋヨ㦂ࡢ࠶ࡾ᪉ࢆ⪃࠼ࡿ఍㆟㸪⚄ᡞ㸪2015.9.13㸬
㏆⸨ ┤ᶞ㸪኱ᶫ 㣴㈼㸪㧗ᶫ 㒓㸪㔝ᮧ ஂ⚈㸪ኴ⏣ ㈗ὒ㸪㉥ᮌ ♸㈗㸪ᕝᓮ ᩄඞ㸪
ஂಖ⏣ ⠜ྖ㸪ᒣཱྀ ᣅὒ㸪⃰἟ ᨻ⨾㸪ᶓᡭ ಙ᫛㸪బᶫ ᖾᏊ㸪㰺⸨ ┿୍㑻
⮫ᗋ◊✲᥎㐍࡟ྥࡅࡓ㛵ಙᆅ༊ᅜ❧⑓㝔⸆๣ᖌ఍ࡢྲྀ⤌ࡳ࡟ࡘ࠸࡚㹼➨ 2 ሗ㹼
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍㸪ᮐᖠ㸪2015.10.1㸬
㧗ᮌ ᜨ⨾㸪⸨ᕝ ཭Ꮚ㸪➉ୗ ᬛᜨ㸪ඵ௦ ᬛᏊ㸪✄ྜྷ ⨾⏤⣖㸪㔠ග ❶Ụ㸪୰ᕝ ⏤⨾㸪
ᮏ ஂ⨾Ꮚ㸪ᔱᒸ ⥳㸪㏆⸨ ┤ᶞ㸪຾ᾏ Ꮫ㸪༓⏣ ᫀஅ㸪ஂಖ⏣ ⠜ྖ㸪㇂ᆅ ㇏㸪
㕥ᮌ ⩏ᙪ㸪ᵻᒣ ᖾᙪ
First-in-human ➨Ϩ┦་ᖌ୺ᑟ἞㦂ࡢᐇ᪋ࢆ㏻ࡋ࡚ࡢホ౯࡜⪃ᐹ
➨ 69 ᅇᅜ❧⑓㝔⥲ྜ་Ꮫ఍㸪ᮐᖠ㸪2015.10.2㸬
᭷㤿 ⚽ᶞ㸪㏆⸨ ┤ᶞ㸪㏆⸨ ᬛᏊ㸪⏣ᓮ ṇಙ㸪ᑎඖ ๛㸪Ỉ஭ ㈗モ㸪Ώ㑓 㐩ஓ
་⸆ရࣜࢫࢡ⟶⌮ィ⏬࡟ྥࡅࡓ⑓㝔⸆๣ᖌࡢ〇㐀㈍኎ᚋㄪᰝᨭ᥼࡟㛵ࡍࡿ᳨ウ
ᖹᡂ 27 ᖺᗘ᪥ᮏ⑓㝔⸆๣ᖌ఍⑓㝔⸆ᒁ༠㆟఍㸭Ꮫ⾡ࣇ࢛࣮࣒ࣛ㸪ᶓ὾㸪2015.11.22
✄ྜྷ⨾⏤⣖, ᚋ⸨⨾✑, ῝ᕝᜨ⨾Ꮚ
Portfolio ᐇ⏝∧ࡢసᡂ Ɇᶆ‽໬࣒࢝ࣜ࢟ࣗࣛ࡟ᇶ࡙࠸ࡓホ౯ࢶ࣮ࣝࢆ᳨ウɆ
➨ 36 ᅇ ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍Ꮫ⾡⥲఍, ᮾி, 2015.12.10
[ ㅮ₇ ]
㏆⸨ ┤ᶞ
἞㦂࣭⮫ᗋ◊✲࡟ᚲせ࡞▱㆑ࢆ⸆๣ᖌࡢᢏ⬟ྥୖ࡟࡝࠺ᒎ㛤ࡍࡿ࠿㸽
ᖹᡂ 26 ᖺᗘ஑ᕞᆅ༊ᅜ❧⑓㝔⸆๣ᖌ఍ࢫ࢟ࣝ࢔ࢵࣉ◊ಟ㸪༤ከ㸪2015.2.21㸬
✄ྜྷ ⨾⏤⣖
ᅜ㝿ඹྠ἞㦂ࡢ⌧≧࡜ᐇ᪋᫬ࡢ␃ពⅬ
᪥ᮏ⑓㝔⸆๣ᖌ఍୺ദ ➨ 17 ᅇ CRC 㣴ᡂࣇ࢛࣮ࣟ࢔ࢵࣉ◊ಟ఍ࣉࣟࢢ࣒ࣛ㸪ᮾி㸬
2015.3.7
― 164 ―
✄ྜྷ⨾⏤⣖
◊✲ࢆᨭ᥼ࡍࡿࡇ࡜ࡢᮏ㉁
⮫ᗋ◊✲࢖ࣥࢸࣥࢩࣈࣇ࢙࣮ࣟࢩࢵࣉ࢟ࢵࢡ࢜ࣇࢩ࣏ࣥࢪ࣒࢘㸪Ἀ⦖㸪2015.5.8
ᒣཱྀ ᣅὒ㸪㏆⸨ ┤ᶞ
ࡀࢇ⮫ᗋヨ㦂
⮫ᗋ◊✲࢖ࣥࢸࣥࢩࣈࣇ࢙࣮ࣟࢩࢵࣉ㸪Ἀ⦖㸪2015.5.10
㏆⸨ ┤ᶞ
ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖᑐᛂ࡬ࡢ࣏࢖ࣥࢺ
ᐩኈᕷ❧୰ኸ⑓㝔೔⌮ጤဨ఍ㅮ₇఍㸪㟼ᒸ㸪2015.5.21
㏆⸨ ┤ᶞ
ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖᑐᛂ࡬ࡢ࣏࢖ࣥࢺ
ᮾி㒔⑓㝔⸆๣ᖌ఍➨㸯ᅇ⮫ᗋ◊✲ᑓ㛛⸆๣ᖌ㣴ᡂ◊✲఍㸪ᮾி㸪2015.5.22
✄ྜྷ⨾⏤⣖
CRC ᴗົࡢᐇ㝿㸦᭷ᐖ஦㇟࡟ᑐࡍࡿᑐᛂ㸧
ᅜ❧⑓㝔ᶵᵓᮏ㒊୺ദᖹᡂ 27 ᖺᗘึ⣭⪅⮫ᗋ◊✲ࢥ࣮ࢹ࢕ࢿ࣮ࢱ࣮㣴ᡂ◊ಟ㸪ᮾி㸪
2015.5.28
⸨ᕝ ཭Ꮚ
CRC ᴗົࡢᐇ㝿㸦᭷ຠᛶཬࡧᏳ඲ᛶࡢホ౯࡟⏝࠸ࡿ᳨ᰝᶵჾ➼ࡢ⢭ᗘ⟶⌮ࠊ
᳨ᰝࢹ࣮ࢱࡢ㉁ࢆᢸಖࡍࡿ᪉ἲ㸧
ᅜ❧⑓㝔ᶵᵓᮏ㒊୺ദᖹᡂ 27 ᖺᗘึ⣭⪅⮫ᗋ◊✲ࢥ࣮ࢹ࢕ࢿ࣮ࢱ࣮㣴ᡂ◊ಟ㸪ᮾி㸪
2015.5.28
㏆⸨ ┤ᶞ
ᅜ❧⑓㝔ᶵᵓࡢ⮫ᗋ◊✲࡜἞㦂ࡢ⌧≧࡜௒ᚋ㸬
CRO ◊ಟ఍㸪ᮾி㸬2015.5.28
㏆⸨ ┤ᶞ
἞㦂ᑂᰝጤဨ఍ࡢᙺ๭࡜ᶵ⬟
ᖹᡂ 27 ᖺᗘᅜබ⚾❧኱Ꮫ⑓㝔་⒪ᢏ⾡㛵ಀ⫋ဨ◊ಟ㸪ᮾி㸪2015.6.24
㏆⸨ ┤ᶞ
ேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮ᣦ㔪ࠖᨵṇࡢ࣏࢖ࣥࢺ㸬
ᮾி㒔⑓㝔⸆๣ᖌ఍◊✲ึᚰ⪅ࡢࡓࡵࡢ⤫ྜ◊✲೔⌮ᣦ㔪࡟㛵ࡍࡿ◊ಟ఍㸪ᮾி㸬
2015.7.25
― 165 ―
㏆⸨ ┤ᶞ
⮫ᗋ◊✲࡟ᚲせ࡞▱㆑ࢆ⌮ゎࡍࡿࡓࡵ࡟㹼ࠕேࢆᑐ㇟࡜ࡍࡿ་Ꮫ⣔◊✲࡟㛵ࡍࡿ೔⌮
ᣦ㔪ࠖࢆࡩࡲ࠼࡚㹼㸬
☬⏣ᕷ❧⥲ྜ⑓㝔⮫ᗋ◊✲◊ಟ఍㸪㟼ᒸ㸬2015.7.30
㏆⸨ ┤ᶞ
἞㦂ᑂᰝጤဨ఍ࡢᙺ๭࡜ᶵ⬟
᪥ᮏ⑓㝔⸆๣ᖌ఍୺ദ➨ 18 ᅇ CRC 㣴ᡂ◊ಟ఍㸪ᮾி㸪2015.9.2
㏆⸨ ┤ᶞ
⮫ᗋ◊✲࡟ᚲせ࡞ไᗘ࣭ᡭ⥆ࡁ࡜ࡣ
ᮾி་⛉ṑ⛉኱Ꮫ➨ 46 ᅇ኱Ꮫ㝔ࢭ࣑ࢼ࣮㸪ᮾி㸪2015.9.17
[ࡑࡢ௚]
㏆⸨┤ᶞ
㸦ᗙ㛗㸧CRC ࡀᐇ㊶ࡍ࡭ࡁ Site Management ࡜ࡣ㸽
➨ 15 ᅇ CRC ࡜⮫ᗋヨ㦂ࡢ࠶ࡾ᪉ࢆ⪃࠼ࡿ఍㆟ 2015 ࠊ⚄ᡞࠊ2015.9.12
✄ྜྷ⨾⏤⣖
㸦ᗙ㛗࣭₇⪅㸧ࢡࣜࢽ࢝ࣝࢡ࢚ࢵࢩࣙࣥ࠿ࡽࣜࢧ࣮ࢳࢡ࢚ࢵࢩࣙࣥ࡬ࠊ◊✲ィ⏬࠿ࡽ
㐺ษ࡞ࢹ࣮ࢱࢭࢵࢺ࡜ゎᯒ࡬㸬CRC ࡜ࡋ࡚ࡢ⮫ᗋ◊✲࡬ࡢ㛵ࢃࡾ
➨ 36 ᅇ ᪥ᮏ⮫ᗋ⸆⌮Ꮫ఍Ꮫ⾡⥲఍, ᮾி, 2015.12.09
― 166 ―
㻌
㻌
㻌
㻌
どぬ◊✲㒊㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
どぬ◊✲㒊
1. ⱥᩥㄽᩥ
Fujinami K, Zernant J, Chana RK, Wright GA, Tsunoda K, Ozawa Y, Tsubota K,
Robson AG, Holder GE, Allikmets R, Michaelides M, Moore AT.
Clinical and molecular characteristics of childhood-onset Stargardt disease.
Ophthalmology. 2015 Feb;122(2):326-34. 3.732
Kuniyoshi K, Ikeo K, Sakuramoto H, Furuno M, Yoshitake K, Hatsukawa Y, Nakao A,
Tsunoda K, Kusaka S, Shimomura Y, Iwata T.
Novel nonsense and splice site mutations in CRB1 gene in two Japanese patients with
early-onset retinal dystrophy.
Doc Ophthalmol. 2015 Feb;130(1):49-55. 0.832
Kato Y, Tsunoda K, Fujinami K, Iwata T, Saga M, Oguchi Y.
Association of Retinal Artery and Other Inner Retinal Structures With Distribution of
Tapetal-like Reflex in Oguchi's Disease.
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2162-72. 1.840 1.840
Yamane M, Ogawa Y, Fukui M, Kamoi M, Saijo-Ban Y, Yaguchi S, Mukai S, Kawakita
T, Simmura S, Tsubota K.
Long-term rebamipide and diquafosol in two cases of immune-mediated dry eye.
Optom Vis Sci. 2015 Apr;92(4 Suppl 1):S25-32. 0.671
Kato Y, Tsunoda K, Fujinami K, Iwata T, Saga M, Oguchi Y.
Association of Retinal Artery and Other Inner Retinal Structures With Distribution of
Tapetal-like Reflex in Oguchi's Disease.
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2162-72. 1.840
Miyake Y, Tsunoda K.
Occult macular dystrophy.
Jpn J Ophthalmol. 2015 Mar;59(2):71-80. 1.058
― 167 ―
Katagiri S, Hayashi T, Yoshitake K, Sergeev Y, Akahori M, Furuno M, Nishino J, Ikeo
K, Tsunoda K, Tsuneoka H, Iwata T.
Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C
Mutation (p.E591K).
Ophthalmic Genet. 2015 Jun;36(2):137-44. 0.600
Kuniyoshi K, Sakuramoto H, Yoshitake K, Ikeo K, Furuno M, Tsunoda K, Kusaka S,
Shimomura Y, Iwata T.
Reduced rod electroretinograms in carrier parents of two Japanese siblings with
autosomal recessive retinitis pigmentosa associated with PDE6B gene mutations.
Doc Ophthalmol. 2015 Aug;131(1):71-9. 0.832
Mizuno M, Fujinami K, Watanabe K, Akiyama K.
Macular Hole Associated with Vogt-Koyanagi-Harada Disease at the Acute Uveitic
Stage.
Case Rep Ophthalmol. 2015 Sep 15;6(3):328-32
Fukui M, Ogawa Y, Shimmura S, Hatou S, Ichihashi Y, Yaguchi S, Hirayama M,
Kawakita T, Tsubota K.
Possible involvement of epithelial-mesenchymal transition in fibrosis associated with
IgG4-related Mikulicz's disease.
Mod Rheumatol. 2015 Sep;25(5):737-43.
Nakamura N, Akiyama K, Shigeyasu C, Yamada M.
Surgical repair of orbital fat prolapse by conjunctival fixation to the sclera.
Clin Ophthalmol. 2015 Sep 18;9:1741-4. 0.661
Nakanishi A, Ueno S, Kawano K, Ito Y, Kominami T, Yasuda S, Kondo M, Tsunoda K,
Iwata T, Terasaki H.
Pathologic Changes of Cone Photoreceptors in Eyes With Occult Macular Dystrophy.
Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7243-9. 1.840
― 168 ―
Kaido M, Kawashima M, Yokoi N, Fukui M, Ichihashi Y, Kato H, Yamatsuji M, Nishida
M, Fukagawa K, Kinoshita S, Tsubota K.
Advanced dry eye screening for visual display terminal workers using functional visual
acuity measurement: the Moriguchi study.
Br J Ophthalmol. 2015 Nov;99(11):1488-92. 1.532
Otake K, Azukizawa S, Takeda S, Fukui M, Kawahara A, Kitao T, Shirahase H.
Novel 2,7-Substituted (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids:
Peroxisome Proliferator-Activated Receptor DŽ Partial Agonists with Protein-Tyrosine
Phosphatase 1B Inhibition.
Chem Pharm Bull (Tokyo). 2015;63(12):998-1014.
Iida K, Ohkuma Y, Hayashi T, Katagiri S, Fujita T, Tsunoda K, Matsuura T, Yamada H,
Tsuneoka H.
A novel splice site OPA1 mutation causes exon 10 skipping in Japanese patients with
dominant optic atrophy.
Ophthalmic Genet. In press. 0.600
Kuniyoshi K, Muraki S, Ueyama H, Toyoda F, Sakuramoto H, Ogita H, Irifune M,
Nakao A, Yamamoto S, Tsunoda K, Iwata T, Ohji M, Shimomura Y.
Novel mutations in the gene for ǂ-subunit of retinal cone cyclic nucleotide-gated
channels in a Japanese patient with congenital achromatopsia.
Jpn J Ophthalmol. In press.
2. ࿴ᩥㄽᩥ
3. ⴭ᭩࣭⥲ㄝ
ゅ⏣࿴⦾
࠙Diagnosticsࠚ⮬Ⓨ⺯ග࡟ࡼࡿ║ᗏほᐹ 㑇ఏᛶ⥙⭷⑌ᝈ
║⛉ࢢࣛࣇ࢕ࢵࢡ 4(2): 140-147, 2015.
▼⏣᫴ࠊᑠἑὒᏊࠊ㏆⸨ᓠ⏕ࠊ୰⃝ᚭࠊᖹぢᜤᙪࠊ⸨ἼⰾࠊᏳᕝຊࠊᒣᇛ೺ඣ㸬
ᗙㄯ఍ ⥙⭷◊✲࣭デ⒪ࡢᮍ᮶ண᝿ᅗ
Retina Medicine 4(1): 1 -9 2015
― 169 ―
⸨Ἴⰾ
≉㞟㸸⥙⭷ศ㔝ࡢᮍ᮶ண᝿ᅗ ⥙⭷㟁Ẽ⏕⌮Ꮫࡢᮍ᮶ண᝿ᅗ
Retina Medicine 4(1): 38 -49 2015.
⸨Ἴⰾ
◪Ꮚయ࣭⥙⭷⑓ኚࡢデ࠿ࡓ㸫⚾ࡣࡇ࠺デࡿ㸫/ 3.ᡤぢ࡜⑓ែ
3)
Stargardt ⑓
║⛉ 57(4):624-640, 2015.
⸨Ἴⰾ
◪Ꮚయ࣭⥙⭷⑓ኚࡢデ࠿ࡓ㸫⚾ࡣࡇ࠺デࡿ㸫/ 1.⑕≧࡜㚷ูデ᩿ 5)⩈
ᝈ
║⛉ 57(4):575-584, 2015.
⚟஭ṇᶞ
ゅ⭷⛣᳜ᚋࡢ Phakic IOL
࠶ࡓࡽࡋ࠸║⛉ࠊ32 (5): 669-670, 2015.
ゅ⏣࿴⦾
࢜࢝ࣝࢺ㯤ᩬࢪࢫࢺࣟࣇ࢕㸦୕Ꮿ⑓㸧
║⛉་ࡢᡭᘬࡁ
᪥ᮏࡢ║⛉ 86 (8), 48-49, 2015
ゅ⏣࿴⦾
ࠕ║ᗏ⮬Ⓨ⺯ග࡟ࡼࡿ⥙⭷⑌ᝈࡢデ᩿ࠖ
ᮾி㒔║⛉་఍఍ሗ 233:2-10, 2015
ゅ⏣࿴⦾
༸㯤ᵝ㯤ᩬࢪࢫࢺࣟࣇ࢕
║⛉ 57 (4): 641-645, 2015
⸨Ἴ ⰾ
⤖ᯝࡢぢ࠿ࡓղ ᒁᡤ ERG
║⛉ࢣ࢔ 17(11):47-56, 2015
Ώ㎶೺ࠊゅ⏣࿴⦾
16㸬ගᖸ΅᩿ᒙィ 2) ᚋ║㒊 OCT յ⥙⭷⳼ⷧ
║⛉᳨ᰝ࢞࢖ࢻ➨ 2 ∧㸦In press㸧
― 170 ―
࣭᫂᫨┣ࡢ㚷ู⑌
4. Ꮫ఍Ⓨ⾲
㸺ᅜ㝿Ꮫ఍Ⓨ⾲㸼
ARVO annual meeting 2015 (The Association for Research in Vision and
Ophthalmology), Denver, Colorado, USA, 3rd to 7th, May, 2015
Fujinami K, Hayashi T, Kuniyoshi K, Kondo M, Ueno S, Shinoda K, Tsubota K,
Miyake Y, Tsunoda K, Iwata T.
Japan Whole Exome Project for Inherited Retinal Diseases 2014
Sasaki M, Kato Y, Hirakata T, Fujinami K, Tsunoda K, Watanabe K, Akiyama K,
Noda T.
Value of quantitative changes in pigment epithelial detachments predictive of
recurrent exudative age-related macular degeneration.
Segreev Y, Pogrebniak K, Fujinami K, Falsini B, Zein WM, Goetz KE,
Jayasundera T, Michaelides M, Brooks BP, Sieving PA
Stargardt ABCA4 muration analysis in trans-membrane and nucleotide-binding
domain
Fakin A, Robson AG, Holder GE, Fujinami K, Allikmets R, Zernant J, Moore AT,
Michaelides M, Webster AR.
Phenotype and progression of retinal degeneration in patients nullizygous for
ABCA4.
ISCEV symposium 2015 (International Society for Clinical Electrophysiology of Vision),
Ljubljana, Slovenia, 22nd-27th, July, 2015
Tamaki S, Nakamura N, Mizuno Y, Noda T, Fujinami K, Tsunoda K.
‘Screening of cone dysfunction by a handheld ERG device, RETevalTM.’
Hata M, Fujinami K, Iwata T, Noda T, Tsunoda K.
Clinical and genetic characteristics of a Japanese family with autosomal dominant
retinitis pigments.
Akiyama K, Fujinami K, Watanabe K, Nakamura N, Noda T, Miyake Y,
Tsunoda K.
― 171 ―
Inner retinal macular dysfunction in patients with ‘macula-on’ rhegmatogenous
retinal detachment.
Fujinami K, Hayashi T, Kuniyoshi K, Kondo M, Ueno S, Shinoda K, Tsubota K,
Miyake Y, Tsunoda K, Iwata T.
Japan whole exome project for inherited retinal diseases 2014
Fakin A, Robson AG, Fujinami K, Moore AT, Webster AR, Michaelides M,
Holder GE.
Retina-wide disease and foveal sparing in ABCA4-related retinopathy.
World Ophthalmology Congress (WOC), Guadalajara, Mexico, 5th-9th, February
2016.
Mizuno M, Akiyama K, Mizuno Y, Fukui M, Ozu C, Saito S, Noda T: Association
between intraocular pressure elevation and anterior chamber depth during
robot-assisted radical prostatectomy in the steep Trendelenburg position
Fujii A, Akiyama K, Fujinami K, Watanabe K, Noda T: One-year outcome of
intravitreal aflibercept injections for age-related macular degeneration: comparison
between treatment-naïve and treatment-converted cases.
Akiyama K, Fujinami K, Watanabe K, Tsunoda K, Noda T:
Epiretinal membrane development after vitrectomy for rhegmatogenous retinal
detachment: visual outcome and clinical characteristics.
㸺ᅜ㝿ᣍᚅㅮ₇㸼
Asia-ARVO 2015 (The Association for Research in Vision and Ophthalmology),
Yokohama, Japan, 16th-19th, February, 2015.
Fujinami K.
Stargardt Disease with Foveal Sparing Phenotype.
Special Interest Group 4 Mechanism of Retinal Degeneration.
APAO congress 2015(Asia-Pacific Academy of Ophthalmology), Guangzhou, China,
April 1, 2015.
Fujinami K.
Stargardt Disease with Foveal Sparing Phenotype.
― 172 ―
The 9th APVRS Congress (Asia Pacific Vitreo-retina Socoity), Sydney, Australia,
August 1, 2015.
Fujinami K.
Comprehensive clinical and electrophysiological assessment crucial for targeted
genetic screening and molecular genetic diagnosis.
The seminar of the Ophthalmic Genetics and Visual Function Branch, National Eye
Institute, National Institute of Health, Bethesda, MA, USA. October 7, 2015.
Fujinami K.
ABCA4-associated retinal disorder -Translational approach aiming for treatment-.
4th Japan-Korea Joint Symposium of Clinical Electrophysiology of Vision, Seoul,
South Korea, October 31, 2015.
Fujinami K.
Japan whole exome project for inherited retinal diseases 2014.
Ophthalmic Genetics Seminar 2016, UCL Institute of Ophthalmology, London, United
Kingdom, February 17, 2016.
Fujinami K.
Inherited retinal dystrophy in Japanese population.
㸺ᅜෆᏛ఍Ⓨ⾲㸼
ゅ⭷࢝ࣥࣇ࢓ࣛࣥࢫࠊ㧗▱ࠊ2015 ᖺ 2 ᭶ 12 ᪥
⚟஭ṇᶞ, ஭ᡭṊ ࠊᕷᶫ៞அࠊ୕ᮌᜨ⨾Ꮚࠊᕝ໭ဴஓࠊ⚟ᮏගᶞࠊᆤ⏣୍⏨ࠊ
ᡞ⏣㑳Ꮚ
෌Ⓨࡍࡿ࢔࣋ࣜࣀゅ⭷ࢪࢫࢺࣟࣇ࢕࡟ᑐࡋ࡚ KeraKlear ேᕤゅ⭷⛣᳜⾡ࢆ⾜ࡗࡓ 1 ౛
⛙ᮍ⛥ࠊ⚟஭ṇᶞࠊỈ㔝჆ಙࠊ኱㔝ᘓ἞ࠊ㔝⏣ᚭ
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮࡟࠾ࡅࡿ 1 ᖺ㛫ࡢゅ⭷⛣᳜౛ࡢ᳨ウ
➨ 119 ᅇ᪥ᮏ║⛉Ꮫ఍⥲఍ࠊᮐᖠࠊ2015 ᖺ 4 ᭶ 16 ᪥
Ỉ㔝㞞᫓ࠊ⸨ἼⰾࠊΏ㎶೺ࠊ⛅ᒣ㑥ᙪࠊゅ⏣࿴⦾ࠊ㔝⏣ᚭ
Vogt-ᑠᰗ-ཎ⏣⑓⨯ᝈᚋ࡟Ⓨ⑕ࡋࡓ㯤ᩬ෇Ꮝ࡟ᑐࡋ◪Ꮚయᡭ⾡ࢆ⾜ࡗࡓ୍౛
― 173 ―
ᐙஂ୍ගࠊᚋ⸨⪽ࠊ኱἟୍ᙪࠊ๓⏣┤அࠊ㔝⏣ᚭ
๓║㒊ගᖸ΅᩿ᒙィࢆ⏝࠸ࡓ⾡ᚋ๓ᡣ῝ᗘண ⢭ᗘࡢ║ෆࣞࣥࢬูẚ㍑
⋢⨨᝷୍ᮁࠊ୰ᮧዉὠᏊࠊ⸨ἼⰾࠊỈ㔝჆ಙࠊ㔝⏣ᚭࠊゅ⏣࿴⦾
⡆᫆ᆺࣇࣜࢵ࣮࢝⥙⭷㟁఩ィ࡟ࡼࡿ࢜࢝ࣝࢺ㯤ᩬࢪࢫࢺࣟࣇ࢕ࡢ㗹యᶵ⬟ホ౯
బࠎᮌ┿⌮Ꮚࠊᖹᙧᑑᙯࠊຍ⸨ᝆࠊ⸨Ἴⰾࠊゅ⏣࿴⦾ࠊΏ㎶೺ࠊ⛅ᒣ㑥ᙪࠊ㔝⏣ᚭ
࢔ࣇࣜ࣋ࣝࢭࣉࢺ἞⒪㸯ᖺᚋࡢどຊ࡟ᑐࡍࡿ⥙⭷Ⰽ⣲ୖ⓶ୗ⑓ኚࡢᙳ㡪
ࣇ࢛࣮ࢧ࣒ 2015 ➨ 58 ᅇ᪥ᮏࢥࣥࢱࢡࢺࣞࣥࢬᏛ఍⥲఍ࠊ኱㜰ࠊ2015 ᖺ 7 ᭶ 11 ᪥
⸨஭࠶࠿ࡡࠊ⚟஭ṇᶞࠊỈ㔝჆ಙࠊ㔝⏣ᚭ
୧║࡟ࢥࣥࢱࢡࢺࣞࣥࢬ࡟ࡼࡿゅ⭷ឤᰁ⑕ࢆ᮶ࡋࡓ㧗㱋⪅ࡢ୍౛
➨ 52 ᅇ᪥ᮏ║ឤᰁ⑕Ꮫ఍ࠊ኱㜰ࠊ2015 ᖺ 7 ᭶ 10 ᪥
Ỉ㔝㞞᫓ࠊ⚟஭ṇᶞࠊỈ㔝჆ಙࠊ㔝⏣ᚭ
୧║ࡪ࡝࠺⭷⅖ࢆకࡗࡓ∦║ᛶ࢔࢝ࣥࢺ࢔࣓࣮ࣂゅ⭷⅖ࡢ୍౛
➨ 63 ᅇ᪥ᮏ⮫ᗋどぬ㟁Ẽ⏕⌮Ꮫ఍ ྡྂᒇࠊ2015 ᖺ 8 ᭶ 29 ᪥
๓⏣ளᕼᏊࠊ⸨Ἴⰾࠊ㔝⏣ᚭࠊᒾ⏣ᓅࠊ୕Ꮿ㣴୕ࠊゅ⏣࿴⦾
ࠕ⮬ぬ⑕≧ࢆᣢࡓ࡞࠸࢜࢝ࣝࢺ㯤ᩬࢪࢫࢺࣟࣇ࢕࡟≉ᚩⓗ࡞⮫ᗋᡤぢࠖ
୰ᮧዉὠᏊࠊ⋢⨨᝷୍ᮁࠊ㔝⏣ᚭࠊ⸨Ἴⰾࠊゅ⏣࿴⦾
RETeval Complete™࡟ࡼࡾデ᩿࡟⮳ࡗࡓ㑇ఏᛶ⥙⭷⑌ᝈࡢᑠඣ౛
⸨ἼⰾࠊᯘᏕᙲࠊᅧྜྷ୍ᶞࠊ㏆⸨ᓠ⏕ࠊୖ㔝┿἞ࠊ⠛⏣ၨࠊᆤ⏣୍⏨ࠊᒾ⏣ᓅࠊ
୕Ꮿ㣴୕ࠊゅ⏣࿴⦾
Japan whole exome project for inherited retinal diseases 2014
➨ 69 ᅇ᪥ᮏ⮫ᗋ║⛉Ꮫ఍ࠊྡྂᒇࠊ2015 ᖺ 10 ᭶ 22 ᪥
ゅ⏣࿴⦾ࠊ▼㱟㕲ᶞࠊ㣤⏣▱ᘯࠊ୸Ꮚ୍ᮁࠊྂἨⱥ㈗
࢖ࣥࢫࢺࣛࢡࢩࣙࣥࢥ࣮ࢫ
║ᗏ⮬Ⓨ⺯ගࢆ౑࠸ࡇ࡞ࡍ
⚟஭ṇᶞࠊᑠᕝⴥᏊࠊࣞࢨ࣭ࢲࢼࠊ࣒࣭࢟ࢫࢸࣛࠊࣅࢡࢱ࣮࣭࣌ࣞࢵࢶࠊ❧ᯇ⏤ెᏊࠊ
― 174 ―
ᒣ᰿ࡳ࠾ࠊᑠᕝㆤࠊすᲄ⿱⨾Ꮚࠊ㬞ᒃ⍞ຍࠊᆤ⏣୍⏨
║៏ᛶ⛣᳜∦ᑐᐟ୺⑓ࡢᅜ㝿デ᩿ᇶ‽ࡢឤᗘ࡜≉␗ᗘࡢ᳨ウ
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ⱝᡭ◊✲⪅Ⓨ⾲఍ࠊᮾிࠊ2015 ᖺ 11 ᭶ 2 ᪥
Ỉ㔝㞞᫓ࠊ⛅ᒣ㑥ᙪࠊỈ㔝჆ಙࠊ㔝⏣ᚭࠊᑠὠ඙୍㑻ࠊᩧ⸨ྐ㑻
ࣟ࣎ࢵࢺᨭ᥼᰿἞ⓗ๓❧⭢඲᦬ฟ⾡࡟࠾ࡅࡿ⾡୰ࡢ║ᅽୖ᪼࡜୕ḟඖ๓║㒊 OCT ࢆ
⏝࠸ࡓ⾡๓ࡢ๓ᡣ῝ᗘ࡟㛵ࡍࡿ᳨ウ
ゅ⭷࢝ࣥࣇ࢓ࣛࣥࢫࠊ㛗㔝ࠊ2016 ᖺ 2 ᭶ 19 ᪥
⚟஭ṇᶞࠊᑠᕝⴥᏊࠊྥ஭ៅࠊᏳ㔛㍤ࠊ㬞ᒃ⍞ຍࠊᆤ⏣୍⏨
║៏ᛶ⛣᳜∦ᑐᐟ୺⑓࡟࠾ࡅࡿ VAMP8 ࡢⓎ⌧ࡢ᳨ウ
⛙ᮍ⛥ࠊ⚟஭ṇᶞࠊỈ㔝჆ಙࠊ㔝⏣ᚭ
ほ⾑ᘧ⾑ᅽィࢆ⏝࠸ࡓゅ⭷ෆ⓶⛣᳜ graft సᡂ᫬ࡢேᕤ๓ᡣෆᅽࡢ ᐃ
㸺ᅜෆㅮ₇㸼
ࡵࡊࡏ㸟ࢥࣝࢽ࢔ࡢ㕲ேࠊᮾிࠊ2015 ᖺ 2 ᭶ 27 ᪥
⚟஭ṇᶞ
࠶ࡓࡽࡋ࠸ேᕤゅ⭷⛣᳜⾡㸹KeraKlear ேᕤゅ⭷
➨ 786 ᅇᮾி㒔║⛉㞟ᅋ఍ࠊᮾிࠊ2015 ᖺ 8 ᭶ 20 ᪥
⚟஭ṇᶞࠊ஭ᡭṊࠊ⛙ᮍ⛥ࠊỈ㔝჆ಙࠊ୕ᮌ⨾ᜨᏊࠊᆤ⏣୍⏨ࠊᡞ⏣㑳Ꮚ
἞⒪ⓗ࣮ࣞࢨ࣮ゅ⭷ษ㝖⾡ 㸦PTK㸧ࡢᐇ㝿
║⛉ᡭ⾡ࡢᑎᏊᒇࠊᮾிࠊ2015 ᖺ 7 ᭶ 2 ᪥
⛅ᒣ㑥ᙪ
ࣂࢵࢡࣝᡭ⾡ࡢࢥࢶ ௜ࡅ᪉࡜እࡋ᪉
⥙⭷⑌ᝈࢆ⪃࠼ࡿ఍ࠊᮾிࠊ2015 ᖺ 9 ᭶ 2 ᪥
⛅ᒣ㑥ᙪ
⚾ࡢ⑓デ㐃ᦠࡢ⪃࠼᪉ ຍ㱋㯤ᩬኚᡂ
― 175 ―
➨ 2 ᅇ⥙⭷⑌ᝈデ⒪ࢭ࣑ࢼ࣮ in South Tokyoࠊᮾிࠊ2015 ᖺ 9 ᭶ 10 ᪥
⸨஭࠶࠿ࡡ
⛅ᒣ㑥ᙪ㸸PCV ࡟ᑐࡍࡿᢠ VEGF ἞⒪ᡂ⦼࣮Aflibercept ࡟ࡼࡿ༢⊂ึᅇ἞⒪ࡢ㸯ᖺ
ᡂ⦼
⛅ᒣ㑥ᙪࠊᮧୖᬛ᫛ࠊᰘ཭᫂ࠊඵᮌᩥᙪ
ࣃࢿࣝࢹ࢕ࢫ࢝ࢵࢩࣙࣥ DME ⑕౛᳨ウ
➨ 11 ᅇ㥖ࡢ఍ࠊᮾிࠊ2015 ᖺ 11 ᭶ 26 ᪥
⛅ᒣ㑥ᙪ
ᮾி་⒪ࢭࣥࢱ࣮ ⑓㝔⤂௓࣭║⛉እ᮶⤂௓
ᡂᑿ㯞Ꮚ
⥳ෆ㞀⟶⌮࡜⑓デ㐃ᦠ
⚟஭ṇᶞ
ゅ⭷⑌ᝈࡢࣆࢵࢺࣇ࢛࣮ࣝ
㔝⏣ᚭ
ࢺ࣮ࣜࢵࢡ IOL ࢆ⏝࠸ࡓⓑෆ㞀ᡭ⾡
wAMD Round Table Meetingࠊᮾிࠊ2016 ᖺ 1 ᭶ 24 ᪥
㣤⏣▱ᘯࠊ⛅ᒣ㑥ᙪࠊᑿⰼ᫂ࠊ㓇஭ຮࠊᏳᕝຊࠊྜྷ⏣ࡺࡳᏊ
EYLEA
ⱝᡭ║⛉་◊✲఍ 2016ࠊ⚟ᒸࠊ2016 ᖺ 2 ᭶ 27 ᪥
⚟஭ṇᶞ
ゅ⭷࠶ࢀࡇࢀ 㹼࠶ࡿ║⛉་ࡢ 10 ᖺ㛫࠿ࡽᏛࡪ㹼
― 176 ―
㻌
㻌
㻌
㻌
⫈ぬ䞉ᖹ⾮ぬ◊✲㒊㻌
⫈ぬ࣭ᖹ⾮ぬ◊✲㒊
[ ㄽᩥ ]
Homma, A., K. Nakamura, K. Matsuura, J. Mizusawa, R. Onimaru, H. Fukuda and M.
Fujii. "Dose-finding and efficacy confirmation trial of superselective intra-arterial
infusion of cisplatin and concomitant radiotherapy for patients with locally advanced
maxillary sinus cancer (JCOG1212, RADPLAT-MSC)." Jpn J Clin Oncol 45(1): 119-122,
2015
IF: 2.016
Tahara, M., N. Kiyota, J. Mizusawa, K. Nakamura, R. Hayashi, T. Akimoto, Y.
Hasegawa, S. Iwae, N. Monden, K. Matsuura, H. Fujii, Y. Onozawa, A. Homma, A.
Kubota, H. Fukuda and M. Fujii. "Phase II trial of chemoradiotherapy with S-1 plus
cisplatin for unresectable locally advanced head and neck cancer (JCOG0706)." Cancer
Sci 106(6): 726-733. 2015
IF㸸 3.523
Tsukahara, K., A. Kubota, Y. Hasegawa, H. Takemura, T. Terada, T. Taguchi, K.
Nagahara, H. Nakatani, K. Yoshino, Y. Higaki, S. Iwae, T. Beppu, Y. Hanamure, K.
Tomita, N. Kohno, K. Kawabata, M. Fukushima, S. Teramukai and M. Fujii.
"Randomized phase III trial of adjuvant chemotherapy with S-1 after curative
treatment in patients with squamous-cell carcinoma of the head and neck (ACTSHNC)." PLoS One 10(2): e0116965. 2015
IF㸸3.730
Yamashita D, Sun GW, Cui Y, Mita S, Otsuki N, Kanzaki S, Nibu KI, Ogawa K,
Matsunaga T.
Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone,
against noise-induced hearing loss.
J Neurosci Res 93㸸788-795, 2015
impact factor
2.594
Mutai H, Miya F, Fujii M, Tsunoda T, Matsunaga T.
Attenuation of Progressive Hearing Loss in DBA/2J Mice by Reagents that Affect
Epigenetic Modifications Is Associated with Up-Regulation of the Zinc Importer Zip4.
PLoS ONE
impact factor
10(4) 㸸e0124301, 2015
3.234
― 177 ―
Mizutari K, Mutai H, Namba K, Miyanaga Y, Nakano A, Arimoto Y, Masuda S, Morimoto
N, Sakamoto H, Kaga K, Matsunaga T.
High prevalence of CDH23 mutations in patients with congenital high-frequency
sporadic or recessively inherited hearing loss.
Orphanet J Rare Dis. 10㸸60, 2015
impact factor
3.358
Wasano K, Mutai H, Obuchi C, Masuda S, Matsunaga T.
A novel frameshift mutation in KCNQ4 in a family with autosomal recessive nonsyndromic hearing loss.
Biochem Biophys Res Commun.
impact factor
463㸸582-586, 2015
2.297
Miya F, Mutai H, Fujii M, Boroevich KA, Matsunaga T, Tsunoda T.
Gene expression profiling of DBA/2J mice cochleae treated with L-methionine and
valproic acid.
Genomic Data.
5㸸323-325, 2015
Shujiro B. Minami1, Hideki Takegoshi2, Yukiko Shinjo1, Chieko Enomoto1, and Kimitaka
Kaga
Usefulness of Measuring Electrically Evoked Auditory Brainstem Responses in Children
with Inner Ear Malformations During Cochlear Implantation
Acta Otolaryngol. 2015;135(10):1007-15.
impact factor
1.106
Minami SB, Oishi N, Watabe T, Uno K, Kaga K, Ogawa K.
Auditory resting-state functional connectivity in tinnitus and modulation with
transcranial direct current stimulation.
Acta Otolaryngol. 2015 Dec;135(12):1286-92
impact factor
1.106
Hyaluronic acid pretreatment for Sendai virus-mediated cochlear gene transfer.
Kurioka T, Mizutari K, Niwa K, Fukumori T, Inoue M, Hasegawa M, Shiotani A.
Gene Ther. 2015 Sep 11. doi: 10.1038/gt.2015.94. Impact factor;3.10
High prevalence of CDH23 mutations in patients with congenital high-frequency
sporadic or recessively inherited hearing loss.
Mizutari K, Mutai H, Namba K, Miyanaga Y, Nakano A, Arimoto Y, Masuda S, Morimoto
N, Sakamoto H, Kaga K, Matsunaga T.
Orphanet J Rare Dis. 2015 May 13;10:60. Impact factor;3.36
― 178 ―
Baba Y, Fujii M, Maeda T, Suzuki A, Yuzawa S, Kato Y. Deguelin induces apoptosis by
targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell
cancer cell lines. BioMed research international. 2015; Epub 2015/06/16. eng.
Habu, N., Y. Imanishi, K. Kameyama, M. Shimoda, Y. Tokumaru, K. Sakamoto, R.
Fujii, S. Shigetomi, K. Otsuka, Y. Sato, Y. Watanabe, H. Ozawa, T. Tomita, M. Fujii
and K. Ogawa "Expression of Oct3/4 and Nanog in the head and neck squamous
carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II
oral tongue squamous cell carcinoma." BMC Cancer 15: 730. 2015.
Hotta K, Katsuki S, Ohata K, Abe T, Endo M, Shimatani M, Nagaya T, Kusaka T,
Matsuda T, Uraoka T, Yamaguchi Y, Murakami Y, Saito Y.
Efficacy and safety of endoscopic interventions using the short double-balloon endoscope
in patients after incomplete colonoscopy.
Dig Endosc 2015;27:95-8
impact factor 2.058
Uraoka T, Tanaka S, Oka S, Matsuda T, Saito Y, Moriyama T, Higashi R, Matsumoto T.
Feasibility of a novel extra-wide-angle-view colonoscope: a clinical study.
Endoscopy 2015;47:444-8
impact factor 5.053
Uraoka T, Higashi R, Horii J, Harada K, Hori K, Okada H, Mizuno M, Tomoda J, MD,
Ohara N, Tanaka T, MD, Chiu HM, Yahagi N, Yamamoto K.
Prospective evaluation of endoscopic criteria characteristic of sessile serrated
adenoma/polyps. J Gastroentrol 2015;50:555-63
impact factor
4.523
Pioche M, Rivory J, Aguero-Garcete G, Guillaud O, O'Brien M, Lafon C, Reversat N,
Uraoka T, Yahagi N, Ponchon T.
New isolated bovine colon model dedicated to colonic ESD hands-on training:
development and first evaluation.
Surg Endosc 2015;29:3209-15
impact factor
3.256
Oka S, Tamai N, Ikematsu H, Kawamura T, Sawaya M, Takeuchi Y, Uraoka T, Moriyama
T, Kawano H, Matsuda T.
Improved visibility of colorectal flat tumors using image-enhanced endoscopy.
Dig Endosc 2015;27 Suppl 1:35-9
impact factor 2.058
― 179 ―
Goto O, Fujimoto A, Shimoda M, Ochiai Y, Matsuda T, Takeuchi H, Kawakubo H,
Maehata T, Uraoka T, Kameyama K, Kitagawa Y, Yahagi N.
Estimation of subepithelial lateral extent in submucosal early gastric cancer:
retrospective histological analysis.
Gastric Cancer 2015;18:810-6
impact factor 3.719
Goto O, Takeuchi H, Kawakubo H, Matsuda S, Kato F, Sasaki M, Fujimoto A, Ochiai Y,
Horii J, Uraoka T, Kitagawa Y, Yahagi N.
Feasibility of non-exposed endoscopic wall-inversion surgery with sentinel node basin
dissection as a new surgical method for early gastric cancer: a porcine survival study.
Gastric Cancer 2015;18:440-5
impact factor
3.719
Uraoka T, Ochiai Y, Fujimoto A, Goto O, Kawahara Y, Kobayashi N, Kanai T, Matsuda
S, Kitagawa Y, Yahagi N. A novel fully synthetic and self-assembled peptide solution for
endoscopic submucosal dissectionɔinduced ulcer in the stomach.
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
Schölvinck DW, Goto O, Seldenrijk CA, Bisschops R, Horii J, Ochiai Y, Schoon EJ, Schenk
BE, Uraoka T, van Oijen MG, Bergman JJ, Yahagi N, Weusten BL.
Detection of palisade vessels as a landmark for Barrett's esophagus in a Western
population.
J Gastroenterol 2015 [Epub ahead of print]
impact factor 4.523
Yoshioka T, Nishida T, Tsujii M, Kato M, Hayashi Y, Komori M, Yoshihara H, Nakamura
T, Egawa S, Yoshio T, Yamada T, Yabuta T, Yamamoto K, Kinoshita K, Kawai N, Ogiyama
H, Nishihara A, Michida T, Iijima H, Shintani A, Takehara T.
Renal dysfunction is an independent risk factor for bleeding after gastric ESD.
Endosc Int Open 2015:3㸸E39-45
impact factor not yet assigned.
Tsujii Y, Kato M, Inoue T, Yoshii S, Nagai K, Fujinaga T, Maekawa A, Hayashi Y,
Akasaka T, Shinzaki S, Watabe K, Nishida T, Iijima H, Tsujii M, Takehara T.
Integrated diagnostic strategy for the invasion depth of early gastric cancer by
conventional endoscopy and EUS.
Gastrointest Endosc 2015:82:452-9
impact factor 5.369
― 180 ―
Tsujii Y, Nishida T, Nishiyama O, Yamamoto K, Kawai N, Yamaguchi S, Yamada T,
Yoshio T, Kitamura S, Nakamura T, Nishihara A, Ogiyama H, Nakahara M, Komori M,
Kato M, Hayashi Y, Shinzaki S, Iijima H, Michida T, Tsujii M, Takehara T.
Clinical outcomes of endoscopic submucosal dissection for superficial esophageal
neoplasms: a multicenter retrospective cohort study.
Endoscopy 2015: 47 :775-83
impact factor 5.053
Ying J, Tsujii M, Kondo J, Hayashi Y, Kato M, Akasaka T, Inoue T, Shiraishi E, Inoue T,
Hiyama S, Tsujii Y, Maekawa A, Kawai S, Fujinaga T, Araki M, Shinzaki S, Watabe K,
Nishida T, Iijima H, Takehara T.
The effectiveness of an anti-human IL-6 receptor monoclonal antibody combined with
chemotherapy to target colon cancer stem-like cells.
Int J Oncol 2015:46:1551-9
impact factor
3.025
Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K, Tsujii M,
Takehara T, Mori M, Doki Y, Nakajima K.
Gastric endoscopic submucosal dissection under steady pressure automatically
controlled endoscopy (SPACE); a multicenter randomized preclinical trial.
Surg Endosc 2015:29 :2748-55
impact factor
3.256
Akasaka T, Tsujii M, Kondo J, Hayashi Y, Ying J, Lu Y, Kato M, Yamada T, Yamamoto S,
Inoue T, Tsujii Y, Maekawa A, Fujinaga T, Shiraishi E, Hiyama S, Inoue T, Shinzaki S,
Watabe K, Nishida T, Iijima H, Takehara T.
5ǦFU resistance abrogates the amplified cytotoxic effects induced by inhibiting
checkpoint kinase 1 in p53Ǧmutated colon cancer cells.
Int J Oncol 2015:46 :63-70
impact factor
3.025
Kato M, Nishida T, Hamasaki T, Kawai N, Yoshio T, Egawa S, Yamamoto K, Ogiyama H,
Komori M, Nakahara M, Yabuta T, Nishihara A, Hayashi Y, Yamada T, Takehara T.
Outcomes of ESD for patients with early gastric cancer and comorbid liver cirrhosis: a
propensity score analysis.
Surg Endosc 2015:29:1560-6
impact factor
3.256
― 181 ―
Yoshii S, Kato M, Honma K, Fujinaga T, Tsujii Y, Maekawa A, Inoue T, Hayashi Y,
Akasaka T, Shinzaki S, Nishida T, Iijima H, Tsujii M, Morii E, Takehara T.
Esophageal adenocarcinoma with white opaque substance observed by magnifying
endoscopy with narrow band imaging.
Dig Endosc 2015:27 :392-6
impact factor 2.058
Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, Suganuma H, Nishizaki
Y.
Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male
subjects.
World J Gastroenterol 2015:21:12457–67
impact factor
2.369
Kikuchi M, Horie Y, Ebinuma H, Taniki N, Nakamoto N, Kanai T.
Alcoholic Liver Cirrhosis and Significant Risk Factors for the Development of Alcoholrelated Hepatocellular Carcinoma-Japan, 2012
Jpn. J.Alcohol & Drug Dependence 2015:50㸸222-34
impact factor not yet assigned.
Nishizawa T, Uraoka T, Ochiai Y, Suzuki H, Goto O, Fujimoto A, Maehata T, Kanai T,
Yahagi N.
The "two-sword fencing" technique in endoscopic submucosal dissection.
Clin Endosc 2015;48:85-620.
impact factor 5.369
Ikehara H, Saito Y, Uraoka T, Matsuda T, Miwa H.
Specimen retrieval method using a sliding overtube for large colorectal neoplasm
following endoscopic submucosal dissection.
Endoscopy 2015;47 Suppl 1 UCTN:E168-9
impact factor
Nishizawa T, Uraoka T, Suzuki H, Goto O, Ochiai Y, Fujimoto A, Maehata T, Kanai T,
Yahagi N. New endoscopic suturing method: slip knot clip suturing.
Gastrointest Endosc 2015;82:570-1
impact factor 5.369
Tsujii Y, Kato M, Shinzaki S, Takigawa A, Hayashi Y, Nishida T, Iijima H, Tsujii M,
Takehara T.
Polyglycolic acid sheets for repair of refractory esophageal fistula.
Endoscopy 2015: 47 (Suppl 1)㸸E39-40
impact factor 5.053
― 182 ―
Matsui S, Uraoka T, Hasegawa H, Kitagawa Y.
A case of asymptomatic incidental live anisakid worm infestation on a large rectal polyp.
BMJ Case Report 2015:9;2015
impact factor not yet assigned.
Seishima, Uraoka T, Hasegawa H, Okabayashi K, Tsuruta M, Hayashi Y, Kitagawa Y.
Colon cancer arising from a sessile serrated adenoma/polyp detected on positron
emission tomography/computed tomography.
Gastrointest Endosc 2015;82:570-1
impact factor 5.369
Goto O, Takeuchi H, Kawakubo H, Sasaki M, Matsuda T, Matsuda S, Kigasawa Y,
Kadota Y, Fujimoto A, Ochiai Y, Horii J, Uraoka T, Kitagawa Y, Yahagi N.
First case of non-exposed endoscopic wallinversion surgery with sentinel node basindissection for early gastric cancer.
Gastric Cancer 2015;18:434-9
impact factor 3.719
Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M.
A case of gastric adenocarcinoma of fundic gland type resected by combination of
laparoscopic and endoscopic approaches to neoplasia with non-exposure technique
(CLEAN-NET).
Clin J Gastroenterol. 2015;8:393-9
impact factor
not yet assigned.
Takatori Y, Kato M, Sakaguchi E, Banno S, Abe K, Takada Y, Hirata T, Wada M,
Kinoshita S, Takabayashi K, Kikuchi M, Kikuchi M, Fujiyama Y, Uraoka T.
A case of extramedullary involvement of acute monocytic leukemia that presented as
obstructive jaundice.
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
Kato M, Uraoka T, Wada M, Banno S, Kinoshita S, Takabayashi K, Kikuchi M.
Large muscle layer defect of stomach caused by ESD closed by using the endoloop-clips
technique.
Gastrointest Endosc 2015 [Epub ahead of print]
impact factor 5.369
― 183 ―
Yamaguchi T, Inoue T, Nishida T, Kato M, Hayashi Y, Tsujii Y, Maekawa A, Kawai S,
Fujinaga T, Araki M, Nagai K, Yoshii S, Hiyama S, Shinzaki S, Iijima H, Tsujii M,
Takehara T.
Localized gastric amyloidosis mimicking a submucosal tumor-like gastric cancer.
Gastrointest Endosc 82 (1)㸸175-7 Jul (2015)
impact factor 5.369
Makino Y, Miyazaki M, Shigekawa M, Ezaki H, Sakamori R, Yakushijin T, Ohkawa K,
Kato M, Akasaka T, Shinzaki S, Nishida T, Miyake Y, Hama N, Nagano H, Honma K,
Morii E, Wakasa K, Hikita H, Tatsumi T, Iijima H, Hiramatsu N, Tsujii M, Takehara T.
Solitary fibrous tumor of the liver from development to resection.
Intern Med 2015:54:765-70
impact factor
0.904
Ozawa H, Imanishi Y, Ito F, Watanabe Y, Kato T, Nameki H, Isobe K, Ogawa K. PiCO2
monitoring of transferred jejunum perfusion using an air tonometry technique after
hypopharyngeal cancer surgery. Medicine 2015:94, e632.
Yuh Baba, Masato Fujii, Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, and
Yasumasa Kato
Deguelin Induces Apoptosis by Targeting Both EGFR-Akt and IGF1R-Akt Pathways in
Head and Neck Squamous Cell Cancer Cell Lines
BioMed Research International, Article ID 657179, 9 pages, 2015
Impact factor 1.579
Yuh Baba, Yasumasa Kato.
The role of bavacizumab in the management of Head and Neck Squamous Cell
Carcinoma Patients
Chemotherapy Open Access4:163, 2015
Impact factor 0.455
Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, and
Yasumasa Kato.
Mineral trioxide aggregate induces osteoblastogenesis via Atf6
Bone reports2:36-43, 2015
Impact factor 㸫
― 184 ―
Ochiai H, Ikei H, Song C, Kobayashi M, Takamatsu A, Miura T, Kagawa T, Li Q,
Kumeda S, Imai M and Miyazaki Y.
Communication: Physiological and Psychological Effects of Forest Therapy on Middle-Aged Males with High-Normal Blood Pressure.
Int. J. Environ. Res. Public Health 2015 Feb;12(3): 2532-2542
Impact factor 2.493
Ochiai H, Ikei H, Song C, Kobayashi M, Takamatsu A, Miura T, Kagawa T, Li Q
Kumeda S, Imai M and Miyazaki Y.
Communication: Physiological and Psychological Effects of a Forest Therapy Progr
am on Middle-Aged Females.
Int. J. Environ. Res. Public Health 2015 Dec;12(12): 15222-15232
Impact factor 2.493
⸨஭ṇே ୰ဗ㢌⒴࡟࠾ࡅࡿࣄࢺங㢌⭘࢘࢖ࣝࢫឤᰁ࡜໬Ꮫᨺᑕ⥺⒪ἲ 㢌㢕㒊⒴42(3)
325-329,2015
ᓥ⏣㈗ಙ ⸨஭ṇே 㢌㢕㒊ᡥᖹୖ⓶⒴ࡢ⦆࿴ⓗ໬Ꮫ⒪ἲ JOHN 31,1362-1365, 2015
⸨஭ṇே 㢌㢕㒊⒴࡟ᑐࡍࡿ㞟Ꮫⓗ἞⒪ࡢ㐍Ṍ㸫໬Ꮫᨺᑕ⥺⒪ἲࢆ୰ᚰ࡟㸫 㢌㢕㒊እ⛉
25(2),2015
኱཭❶Ꮚࠊ༡ಟྖ㒄ࠊỌ஭㑈ᩯࠊᯇỌ㐩㞝ࠊᴮᮏ༓ỤᏊࠊᆏ⏣ⱥ᫂ࠊ⸨஭ṇேࠊຍᡃྩᏕ
Waardenburg ⑕ೃ⩌ 2 ᆺ࡟ᑐࡍࡿࠊேᕤෆ⪥ᇙࡵ㎸ࡳ⾡ᚋࡢ⫈ぬ࣭ゝㄒⓎ㐩࡟ࡘ࠸࡚
⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉.
87(2) 㸸173-175, 2015
༡ ಟྖ㑻, ᒣᮏ ಟᏊ, ⸨஭ ṇே
ࣅ࢝ࣝࢱ࣑ࢻ༢๣ᢞ୚࡟ࡼࡾ᏶඲ዌຠࢆᚓࡓၚᾮ⭢ᑟ⟶⒴⫵㌿⛣⑕౛ࡢ 1 ౛
㢌㢕㒊እ⛉ 2015 25 ᕳ 2 ྕ Page247-251
ᩧ⸨⿱㍜, ᒸ ᚿ㑻, ⏣୰ಙ἞, ᩪ⸨ ㇏, ụᯇᘯᮁ, ஬༑ᔒṇᗈ, ࿴⏣⚈ᇛ, ᕤ⸨㐍ⱥ, ᑠᯘ
Ύ඾, ஭ୖ㞝ᚿ, ᾆᒸಇኵ, 㣤 ᾈᗣ, ᒣ㔝Ὀ✑, 㭯⏣ ಟ, Ọ⏣ಙ஧, ⶶཎ᫭୍, ᒣཱྀ⿱୍㑻,
బ㔝 ᑀ, ᶔ⏣༤ྐ, ᇼᯇ㧗༤, ᩪ⸨ᙲ୍, ୖ㔝⚽ᶞ, ▼㯮ࡵࡄࡳ, ▼ᕝ⚽ᶞ, ࿡ᒸὒ୍, ኱
಴ᗣ⏨, ⸨┒Ꮥ༤, Ώ㑓⪽᫂, ᮡཎ೺୍.
ෆど㙾᦬㝖ᚋ኱⭠ T1(SM)⒴ࡢ㌿⛣࣭෌Ⓨ࡟㛵ࡍࡿከ᪋タඹྠ◊✲ ኱⭠⒴◊✲఍ࣉࣟࢪ࢙
ࢡࢺ◊✲ࡢ⤖ᯝ࠿ࡽ㸬
⫶࡜⭠ 50 ᕳ 4 ྕ 448-56,2015
― 185 ―
㧗ᯘ 㤾, ᾆᒸಇኵ, ຍ⸨ඖᙪ, ⴠྜᗣ฼, ▮స┤ஂ.
LST ࡢศ㢮࡜ࡑࡢ≉ᚩ㸬
⮫ᗋᾘ໬ჾෆ⛉ 30 ᕳ 9 ྕ 1149-54,2015
ⴠྜᗣ฼, 㣬ᮏဴර, ᮌୗ ⪽, ┦Ⰻㄔ஧, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ᚋ⸨ ಟ, ୰ᮧ⌮ᜨᏊ, す⃝ಇ
ᏹ, ᾆᒸಇኵ, ▮స┤ஂ㸬
༑஧ᣦ⭠⭢⭘࣭⭢⒴ࡢ㚷ูデ᩿࡜἞⒪㸬
ᾘ໬ჾෆど㙾 27 ᕳ 1 ྕ 133-40,2015
ᾆᒸಇኵ, ▮స┤ஂ㸬
ᮍ᮶ࡢ኱⭠ෆど㙾ࣔࢲࣜࢸ࢕࣮㸬
ᾘ໬ჾෆど㙾 27 ᕳ 4 ྕ 696-8,2015
ⴠྜᗣ฼, 㣬ᮏဴර, ┦Ⰻㄔ஧, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ୰ᮧ⌮ᜨᏊ, す⃝ಇᏹ, ᚋ⸨ ಟ, ᾆᒸ
ಇኵ, ▮స┤ஂ㸬
༑஧ᣦ⭠⾲ᅾᛶ⭘⒆࡟ᑐࡍࡿෆど㙾἞⒪ࡢ᪉㔪㸬
ᾘ໬ჾෆど㙾 27 ᕳ 7 ྕ 1095-102,2015
ⴠྜᗣ฼, ᾆᒸಇኵ, ▮స┤ஂ㸬
ࠕ⫶࣭༑஧ᣦ⭠ࠖ࡭࠿ࡽࡎ ༑஧ᣦ⭠ ESD ࠶࡞ࡓࡣࡸࡗ࡚ࡣ࠸ࡅ࡞࠸㸬
ᾘ໬ჾෆど㙾 27 ᕳ 2 ྕ 244-5,2015
㧗ᯘ 㤾, ᾆᒸಇኵ, ▮స┤ஂ㸬
ࠕ኱⭠ࠖ࡭࠿ࡽࡎ ESD ඛ➃⣔࡛ࡇࢀࡣࡸࡗ࡚ࡣ࠸ࡅ࡞࠸㸬
ᾘ໬ჾෆど㙾 27 ᕳ 2 ྕ 279-81,2015
బ㔝 ᑀ, ⏣୰ಙ἞, ᕤ⸨㐍ⱥ, ᩪ⸨ᙲ୍, ᯇ⏣ᑦஂ, ࿴⏣⚈ᇛ, ⸨஭㝯ᗈ, ụᯇᘯᮁ, ᾆᒸಇ
ኵ, ᑠᯘ ᮃ, ୰ᮧᑦᚿ, ᇼ⏣Ḡ୍, ᇼᯇ㧗༤, ᆏᮏ┤ே, ഌ ග⩏, 㭯⏣ ಟ, Ἑ㔝ᘯᚿ, ᶔ⏣༤
ྐ, ➉ෆὒྖ, ⏫⏣ᾈஂ, ᪥ୗ฼ᗈ, ྜྷ⏣┤ஂ, ᖹ⏣୍㑻, ᑎ஭ Ẏ, ᒣ㔝Ὀ✑, 㔠Ꮚ࿴ᘯ, ୰ᓥ
೺, ᆏᮏ ⌶, ᒣཱྀ⿱୍㑻, ⋢஭ᑦே, ୸ᒣᑦᏊ, ᯘ ዉ㑣, ᒸ ᚿ㑻, ᒾ㤋ᓠ㞝, ▼ᕝ⚽ᶞ, ᮧୖ
⩏Ꮥ, ྜྷ⏣ⱱ᫛, ᩪ⸨ ㇏, The Japan NBI Expert Team(JNET)㸬
The Japan NBI Expert Team(JNET)኱⭠ᣑ኱ Narrow Band Imaging(NBI)ศ㢮㸬
Intestine 19 ᕳ 1 ྕ 5-13,2015
ᾆᒸಇኵ㸬
࠙ෆ⛉⑌ᝈࡢデ᩿ᇶ‽࣭⑓ᆺศ㢮࣭㔜⑕ᗘࠚ(➨ 2 ❶) ᾘ໬ჾ ኱⭠⭘⒆㸬
ෆ⛉ 115 ᕳ 6 ྕ 960-4,2015
ᾆᒸಇኵ, ᮌୗ ⪽, 㧗ᯘ 㤾, ຍ⸨ ඖᙪ, ⳥ụ ┿኱㸬
Cold Polypectomy ࡢ᭷⏝ᛶ࡜ࢥࢶ㸬
ᾘ໬ჾෆど㙾 27 ᕳ 10 ྕ 1718-23, 2015
― 186 ―
๓⏿ᛅ㍤, 㣬ᮏဴර, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, ୰ᮧ⌮ᜨᏊ, す⃝ಇᏹ, ᚋ⸨ ಟ, ᾆᒸ
ಇኵ, ▮స┤ஂ㸬
ᾘ໬⟶⒴ࡢ἞⒪᪉㔪ࡢ❧࡚᪉࣭㐍ࡵ᪉ ኱⭠⒴ࡢෆど㙾἞⒪㐺ᛂ࡜ࠊእ⛉࣭⸆≀⒪ἲ㛤ጞ࣭
⛣⾜ࡢࢱ࢖࣑ࣥࢢ㸬
᪥ᮏࢥࣥࣆ࣮ࣗࢱእ⛉Ꮫ఍ㄅ 17 ᕳ 2 ྕ 91-100,2015
ᾆᒸಇኵ, ᯇ⏣ᑦஂ㸬
ᑠᆺ኱⭠࣏࣮ࣜࣉ࡟ᑐࡍࡿ Cold polypectomy㸬
Gastroenterological Endoscopy 57 ᕳ 9 ྕ 2370-8,2015
㧘ᯘ 㤾, ᾆᒸಇኵ, ᮌୗ ⪽, ຍ⸨ඖᙪ, ▮స┤ஂ㸬
ESD ⏝ඛ➃࢔ࢱࢵࢳ࣓ࣥࢺࢆ౑࠸ࡇ࡞ࡍࢥࢶ.
ᾘ໬ჾෆど㙾 27 ᕳ 8 ྕ, 1308-12, 2015
ຍ⸨ඖᙪ, ㉥ᆏᬛྐ, ஭ୖᣅஓ, 㔜ᕝ ⛱
࠙⾑౽ࢆࡳࡓࡽࠚ ⾑౽ࢆࡁࡓࡍ⑌ᝈࡢ≉ᚩ࣭ෆど㙾ീ࡜ᑐฎἲ ⭠⟶Ꮚᐑෆ⭷⑕
ᾘ໬ჾෆど㙾 27(10)㸸1691-1695 Nov 16 (2015)
⸨ᇛගᘯ, ஭ཱྀᖿᓫ, ゅᔱ┤⨾, ຍ⸨ඖᙪ, ᆏ⏣㈨ᑦ, ᕸ⿄ᒇ ಟ, ∦ᒸᖿ⤫, ᓥᒸಇ἞, ▮
స┤ஂ, ⸨ᮏ୍┾, ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍
㠀㟼⬦⒗ᛶୖ㒊ᾘ໬⟶ฟ⾑࡟࠾ࡅࡿෆど㙾デ⒪࢞࢖ࢻࣛ࢖ࣥ.
Gastroenterological Endoscopy 2015:57(8)㸸1648-66
ຍ⸨ඖᙪ, 㜿㒊ᆂ୍㑻, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾, ⸨ᒣ
ὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ
State of the art ኱⭠ ESD ࢆࡵࡄࡗ࡚ ኱⭠ ESD ࡢࢹࣂ࢖ࢫࡢ≉ᚩ࣭౑࠸ศࡅŌŌ኱⭠ࡀ
ࢇ perspective 2015: 2㸸2188-4560
⳥ụ┿኱, ᱵ⏣⍠⨾Ꮚ, 㭯㇂ᗣኴ, ሷ⃝ᏹ࿴, ᯇᔱᡂᚿ, 㜿㒊ᆂ୍ᮁ, ⳥ụ⨾✑, 㧗ᶫṇᙪ, ᒣ
ᓊ⏤ᖾ, すᓮὈᘯ, ᇼỤ⩏๎, 㔠஭㝯඾
㠀౵くⓗ⫢⬡⫫ ᐃ Controlled Attenuation Parameter (CAP)࡟ࡼࡿ࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ
ᝈ⪅ࡢ㚷ู
᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㞧ㄅ 2015:50㸸235-47
ᇼỤ⩏๎, ᾏ⪁἟ᾈ฼, ⳥ụ┿኱, ୰ᮏఙᏹ, 㔠஭㝯඾
ᮏ㑥࡟࠾ࡅࡿ࢔ࣝࢥ࣮ࣝᛶ⫢◳ኚࡢᐇែ
⫢⮚ 2015:56㸸366-8
― 187 ―
ᒸ ឡᏊࠊỈ㇂ ೺ே, ඵᮌ ┤Ꮚ, 㯮ᓥ ⩏᫂, ⴠྜ ༤Ꮚ㸬
ᯈ㛫ᒙ㢮⾲⓶ᄞ⬊ࡀ㢌⵹ෆᑤ✸◚ࡋࡓ1౛.
᪥ᮏᙧᡂእ⛉Ꮫ఍఍ㄅ2015 Jan;35(1):51-55
ⴠྜ༤ᏊࠊỈ㇂೺ேࠊඵᮌ┤ᏊࠊᒸឡᏊࠊ㈗ᚿ࿴⏕㸬
ࣄ࢔ࣝࣟࣥ㓟ὀධ࡟ࡼࡿ㰯⩼ቯṚࡢ1౛㸬
ᙧᡂእ⛉ 2015 Sep;58(9):989-992
ⴠྜ༤ᏊࠊỈ㇂೺ேࠊඵᮌ┤ᏊࠊᒸឡᏊࠊᆏᮏዲ᫛㸬
ຍ㱋ᛶ║▛ୗᆶ⑕࡟ᑐࡍࡿ෌ᡭ⾡⑕౛ࡢ᳨ウ㸬
ᙧᡂእ⛉ 2015 Nov;58(11):1199-1205
[ ⥲ㄝ ]
Homma, A., R. Onimaru, K. Matsuura, K. T. Robbins and M. Fujii. "Intra-arterial
chemoradiotherapy for head and neck cancer." Jpn J Clin Oncol 46(1): 4-12.2016
Kiyota, N., M. Tahara and M. Fujii. "Adjuvant treatment for post-operative head and
neck squamous cell carcinoma." Jpn J Clin Oncol 45(1): 2-6. 2015
ᯇỌ㐩㞝
ඛኳᛶ㞴⫈ඣࡢ㑇ఏᏊኚ␗ࡢ◊✲࡜デ⒪࡟࠾ࡅࡿ᪂ࡋ࠸ືྥ
㡢ኌゝㄒ་Ꮫ
56(3)㸸219-225ࠊ2015
ᯇỌ㐩㞝ࠊ℧ཱྀὒ୍㑻
✺Ⓨᛶ㞴⫈ࡢ⑓ែ
⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ 87(8) 㸸564–572ࠊ2015
༡ ಟྖ㑻
࠙㢦㠃⚄⤒࡜ࡑࡢ࿘㎶-᭱㏆ࡢ㐍Ṍ࡜ࢺࣆࢵࢡࢫࠚ デ᩿ࡢࢺࣆࢵࢡࢫ 㢦㠃⚄⤒㯞⑷࡟ᑐࡍ
ࡿ⏬ീデ᩿
JOHNS 31 ᕳ 6 ྕ Page703-707(2015)
༡ ಟྖ㑻
࠙ࡇࢇ࡞࡜ࡁࡢᑐᛂἲࡀࢃ࠿ࡿ ⪥㰯ဗႃ⛉ᡭ⾡࢞࢖ࢻࠚ ⪥ࡢᡭ⾡ ேᕤෆ⪥ᡭ⾡
⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ 87 ᕳ 5 ྕ Page66-70(2015.04)
༡ ಟྖ㑻
࠙ࢫࢺࣞࢫ࡜⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉ࠚ ࢫࢺࣞࢫ࡜㞴⫈
JOHNS 31 ᕳ 3 ྕ Page297-300(2015)
― 188 ―
Ỉ㊊ 㑥㞝
࠙㧗㱋⪅ࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝ࠚ ⮫ᗋ࡟ᙺ❧ࡘ Q&A ෆ⪥෌⏕ࡀ࡝ࡢ⛬ᗘ㐍ࢇ࡛࠸ࡿࡢ࠿ᩍ
࠼࡚ࡃࡔࡉ࠸
Geriatric Medicine 53 ᕳ 4 ྕ Page367-369(2015.04)
Ỉ㊊㑥㞝
ࠕ⚾ࡢ␃Ꮫࠖ࣎ࢫࢺࣥ MEEI ␃Ꮫ ௰㛫࡟ࡶᨭ࠼ࡽࢀෆ⪥᭷ẟ⣽⬊෌⏕ࡢᛌᣲ
⨾ⷣ No.117 p34-36, 2015 ᖺ 3 ᭶ 20 ᪥
ᒣ⃝୍ᶞ
ᅗㄝࠕ┠࡛ぢࡿ㑇ఏ་Ꮫࠖࢩ࣮ࣜࢬ ࢤࣀ࣒᫬௦ࡢ฿᮶࡜㑇ఏࣜࢸࣛࢩ࣮
ᅜ❧་⒪Ꮫ఍ㄅ ་⒪ 2016;70(2):106-109
ᒣ⃝୍ᶞ
௒᭶ࡢ⏝ㄒࠕḟୡ௦ࢩ࣮ࢡ࢚ࣥࢧ࣮ࠖ
ᅜ❧་⒪Ꮫ఍ㄅ ་⒪ 2015;69(8/9):383
Uraoka T, Hosoe N, Yahagi N.
Colonoscopy: is it as effective as an advanced diagnostic tool for colorectal cancer
screening?
Expert Rev Gastroenterol Hepatol 2015;9:129-32
impact factor
2.417
Moriyama T, Uraoka T, Esaki M, Matsumoto T.
Advanced technology for the improvement of adenoma and polyp detection during
colonoscopy. Dig Endosc 2015;27 Suppl 1:40-4
impact factor
Kato M
Diagnosis and therapies for gastric non-invasive neoplasia.
World J Gastroenterol 2015: 21㸸12513-8
impact factor
2.369
Nishida T, Kato M, Yoshio T, Akasaka T, Yoshioka T, Michida T, Yamamoto M, Hayashi
S, Hayashi Y, Tsujii M, Takehara T.
Endoscopic submucosal dissection in early gastric cancer in elderly patients and
comorbid conditions.
World J Gastrointest Endosc 2015: 7㸸524-31
impact factor not yet assigned.
― 189 ―
Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman
A, Reddy KR, Chang KM.
Distinct features in natural history and outcomes of acute hepatitis C.
J Clin Gastroenterol 2015:49:e31-40
impact factor
3.498
Matsubara K, Kagami M, Nakabayashi K, Hata K, Fukami M, Ogata T, Yamazawa K.
Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by
hypermethylation of imprinting control regions.
Clinical Epigenetics 2015;7(1):90
Impact factor 4.5
Strogantsev R, Krueger F, Yamazawa K, Shi H, Gould P, Goldman-Roberts M, McEwen
K, Sun B, Pedersen R, Ferguson-Smith AC.
Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and nonimprinted monoallelic expression.
Genome Biology 2015;16(1):112
Impact factor 10.8
[ ⴭ᭩ ]
ᯇỌ㐩㞝
✺Ⓨᛶ㞴⫈
௒᪥ࡢ἞⒪ᣦ㔪 2015 ᖺ∧㸦⚟஭ḟኵࠊ㧗ᮌㄔࠊᑠᐊ୍ᡂ࣭⥲⦅㞟㸧ࠊ1410-1411ࠊ་Ꮫ᭩
㝔ࠊ2015.1
ᯇỌ㐩㞝
እࣜࣥࣃ⒦
௒᪥ࡢ἞⒪ᣦ㔪 2015 ᖺ∧㸦⚟஭ḟኵࠊ㧗ᮌㄔࠊᑠᐊ୍ᡂ࣭⥲⦅㞟㸧ࠊ1410-1411ࠊ་Ꮫ᭩
㝔ࠊ2015.1
ᯇỌ㐩㞝
Waardenburg ⑕ೃ⩌
ᑠඣෆ⛉ 2015 ᖺ 47 ᕳቑหྕ㸦ࠗᑠඣෆ⛉࠘
ࠗᑠඣእ⛉࠘⦅㞟ጤဨ఍ඹ⦅㸧ࠊᰴᘧ఍♫ᮾி་
Ꮫ♫ࠊ210-212ࠊ2015.11
༡ಟྖ㑻
EABR ࡜ࡣఱ࡛ࡍ࠿㸽
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪Ϩᕳ㸦ຍᡃྩᏕࠊᒣ୰᪼㸧඲᪥ᮏ⑓㝔ฟ∧఍
66-68 2015.4.20
― 190 ―
༡ಟྖ㑻
⿵⫈ჾ࡜ேᕤෆ⪥ࡢ㐪࠸ࡣఱ࡛ࡍ࠿㸽
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪Ϩᕳ㸦ຍᡃྩᏕࠊᒣ୰᪼㸧඲᪥ᮏ⑓㝔ฟ∧఍
74-76 2015.4.20
༡ಟྖ㑻
㟁Ẽ⫈ぬ࡜ࡣఱ࡛ࡍ࠿㸽
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪Ϩᕳ㸦ຍᡃྩᏕࠊᒣ୰᪼㸧඲᪥ᮏ⑓㝔ฟ∧఍
105-107 2015.4.20
༡ಟྖ㑻
ேᕤෆ⪥ࡣ MRI ࡛ᨾ㞀ࡋࡲࡍ࠿㸽
௒ࡉࡽ⪺ࡅ࡞࠸㸟ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪Ϩᕳ㸦ຍᡃྩᏕࠊᒣ୰᪼㸧඲᪥ᮏ⑓㝔ฟ∧఍
116-119 2015.4.20
⳥ụᏲࠊⴠྜ༤Ꮚࠊ㕥ᮌ೺ྖࠊጲ⏣༑஧
➨Ϫ⦅ ࢣࣟ࢖ࢻ࣭⫧ཌᛶ⒕⑞デ⒪࢞࢖ࢻࣛ࢖ࣥࠊ➨஧❶ ⫧ཌᛶ⒕⑞
ᙧᡂእ⛉デ⒪࢞࢖ࢻࣛ࢖ࣥࠊ137-148ࠊ㔠ཎฟ∧ᰴᘧ఍♫ࠊ2015.4.10.
Yuh Baba, Takanori Nishiyama, Yasumasa Kato
Diagnosis and treatment of accessory parotid gland tumors
International Manual of Oncology Practice, chapter27, pp629-636, Ramon Andrade de
Mello, Springer, 2015
[ Ꮫ఍Ⓨ⾲ ]
Mutai H, Miya F, Fujii M, Matsunaga T.
Attenuation of Progressive Hearing Loss in DBA/2J Mice by Epigenetic-Modifying
Reagents Is Associated with Up-Regulation of the Zinc-Importer Zip4 /Slc39a4.
Association for research in otolaryngology 38th Annual MidWinter Meeting, Baltimore,
Maryland, 2015.2.21-25.
Watabe T, Matsunaga T, Wakabayashi S, Kojima T, Oishi N, Kanzaki S, Ogawa K.
Study of the Association Between the Tinnitus Annoyance and the Genetic Background.
9th international TRI Tinnitus Conference, Michigan,USA, 2015.6.7-10.
― 191 ―
Hosoya M, Fujioka M, Matsunaga T, Ogawa K, Okano H.
A mutated PENDRIN formed intracellular aggregations and caused increase of
susceptibilities for cell stress in the inner ear cells induced from Pendred syndrome
patients-specific iPS cells
The 38th Annual Meeting of the Japan Meuroscience Society, Hyogo, Japan, 2015. 7.2831.
Matsunaga T, Morimoto N, Mutai H.
Audiological Characteristics in Patients Carrying Mutations in SLC26A5 Which
Encodes Prestin- a Longitudinal Study.
Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum,San Francisco, California USA,
2015.8.23-26.
Matsunaga T.
Promises and challenges of next generation sequencing in personalized medicine for
sensorineural hearing loss. Symposium11: Sensorineural Hearing Loss.
13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, Tokyo,
Japan, 2015.12.3-4.
Yuh Baba Deguelin induces apoptosis by targeting EGFR-Akt and IGF1R-Akt
pathways in head and neck cancer. The joint meeting of 4th congress of asian society of
head and neck oncology and 39th annual meeting of japan society for head and neck
cancer, Kobe, Japan, June3-6, 2015
኱཭❶Ꮚࠊ໭ᮧ඘ࠊỌ஭㑈ᩯࠊ༡ಟྖ㑻ࠊᓥ⏣㈗ಙࠊᯇỌ㐩㞝ࠊ஬ᓥྐ⾜ࠊゅ⏣᫭୍ࠊ⸨஭
ṇேࠊຍᡃྩᏕ
ᙜ㝔࡟࠾ࡅࡿ Pendred ⑕ೃ⩌࠶ࡿ࠸ࡣ␲࠸⑕౛ࡢ⫈ຊ⤒㐣࡟ࡘ࠸࡚
᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ᮾி㒔ᆅ᪉㒊఍౛఍ ➨ 206 ᅇᏛ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.3.14.
⸨ᒸṇேࠊ⣽㇂ㄔࠊᯇỌ㐩㞝ࠊᑠᕝ㑳ࠊᒸ㔝ᰤஅ
MYO15A ᪂つ㑇ఏᏊኚ␗⑕౛࠿ࡽࡢ⑌ᝈ≉␗ⓗ iPS ⣽⬊ࡢᶞ❧
➨ 14 ᅇ᪥ᮏ෌⏕་⒪Ꮫ఍⥲఍ࠊ⚄ዉᕝ┴ࠊ2015.3.19-21.
⣽㇂ㄔࠊ⸨ᒸṇேࠊΏ㒊Ꮥኴ㑻ࠊᒸᮏ⌮ᚿࠊ᭮᰿ᓅྐࠊᯇỌ㐩㞝ࠊ㉥ᯇ࿴ᅵࠊᑠᕝ㑳ࠊᒸ㔝
ᰤஅ
ࣄࢺᝈ⪅⏤᮶ PENDRED ⑕ೃ⩌≉␗ⓗ iPS ⣽⬊ࢆ⏝࠸ࡓࣄࢺෆ⪥ PENDRIN 㝧ᛶ⣽⬊ࡢ
ゎᯒ
➨ 14 ᅇ᪥ᮏ෌⏕་⒪Ꮫ఍⥲఍ࠊ⚄ዉᕝ┴ࠊ2015.3.19-21.
― 192 ―
㔠Ꮚ⏤ెࠊ᭷ᮏ཭ᏘᏊࠊ௰㔝ᩔᏊࠊᕤ⸨඾௦ࠊᯇỌ㐩㞝
ඃᛶ㑇ఏࡢ㞴⫈㑇ఏᏊኚ␗ࢆㄆࡵࡓᐙ᪘Ṕࡢ࡞࠸㞴⫈⑕౛
➨ 10 ᅇ᪥ᮏᑠඣ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊ㛗㔝┴ࠊ2015.5.8-9.
㈏㔝ᙬᏊࠊ᳃⏣カᏊࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᑠἙཎ᪼ࠊᮡෆᬛᏊࠊᒸᮏᗣ⚽ࠊᑠᕝ㑳ࠊᯇ
Ọ㐩㞝
Incomplete partition type Ϫወᙧࡢ⮫ᗋ㑇ఏᏛⓗ᳨ウ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
࿴బ㔝ᾈ୍㑻ࠊົྎⱥᶞࠊᑠᕝ㑳ࠊᯇỌ㐩㞝
KCNQ4 ኚ␗࡟క࠺㑇ఏᛶ㞴⫈ 10 ᐙ⣔ࡢ᳨ウ 㹼ຎᛶ㑇ఏࢆ♧ࡋࡓᐙ⣔ࡶྵࡵ࡚㹼
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
໭ᑿᜤᏊࠊᏲᮏ೔Ꮚࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᮡෆᬛᏊࠊቑ⏣బ࿴Ꮚࠊᒸᮏᗣ⚽ࠊᏲᮏカᏊࠊ
ຍᡃྩᏕࠊᯇỌ㐩㞝
㑇ఏᏊゎᯒࢆࡋࡓ Auditory Neuropathy Spectrum Disorder(ANSD)ࡢ DPOAE ࡢ⤒㐣
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
➟಴ዉὠᏊࠊቑ⏣ṇḟࠊቑ⏣బ࿴Ꮚࠊ㜰ᮏᾈ୍ࠊᑠἙཎ᪼ࠊ୕⃝㐓ேࠊ⏥⬟┤ᖾࠊᯇỌ㐩㞝
ప㡢㞀ᐖᆺឤ㡢㞴⫈⑕౛ࡢ࣮࢜ࢪ࢜ࢢ࣒ࣛࡢヲ⣽࡞≉ᚩ࡜㞴⫈㑇ఏᏊኚ␗ࡢ᳨ウ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
Ỉ㊊㑥㞝ࠊົྎⱥᶞࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊቑ⏣బ࿴ᏊࠊᏲᮏ೔Ꮚࠊ㜰ᮏᾈ୍ࠊຍᡃྩᏕࠊ
ᯇỌ㐩㞝
ཎᅉ୙᫂ࡢ㧗㡢㒊㞀ᐖࢆㄆࡵࡿඛኳᛶ㞴⫈࡟࠾ࡅࡿ CDH23 㑇ఏᏊኚ␗ࡢ㢖ᗘ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
⣽㇂ㄔࠊ⸨ᒸṇேࠊᯇỌ㐩㞝ࠊᑠᕝ㑳
PENDRED ⑕ೃ⩌⑌ᝈ≉␗ⓗ iPS ⣽⬊⏤᮶ෆ⪥⣽⬊ࢆ⏝࠸ࡓ⸆๣ࢫࢡ࣮ࣜࢽࣥࢢ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
༡ಟྖ㑻ࠊົྎⱥᶞࠊᇼ஭᪂ࠊ࿴బ㔝ᾈ୍㑻ࠊ᱇㈨Ὀࠊ⏣୰⸨ಙࠊ℧ཱྀဴஓࠊ኱▼┤ᶞࠊ໭
ᮧ඘ࠊ኱཭❶ᏊࠊỌ஭㑈ᩯࠊ஬ᓥྐ⾜ࠊᯇỌ㐩㞝ࠊ⸨஭ṇேࠊຍᡃྩᏕ
୰⪥ᖖᅾ⳦ྀ࡜៏ᛶ୰⪥⅖⣽⳦ྀࡢ 16SrRNA ⳦✀⤌ᡂゎᯒ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ࠊᮾி㒔ࠊ2015.5.20-23.
ົྎⱥᶞࠊᐑ෤ᶞࠊ⸨஭ṇேࠊゅ⏣㐩ᙪࠊᯇỌ㐩㞝
࣓ࢳ࢜ࢽ࣭ࣥࣂࣝࣉࣟ㓟࡟ࡼࡿ DBA/2J ࣐࢘ࢫࡢ㞴⫈㐍⾜ᢚไࡣள㖄࢖࣏࣮ࣥࢱ࣮Zip4 Ⓨ
⌧ࡢୖ᪼࡜㛵㐃ࡍࡿ
➨ 9 ᅇ᪥ᮏ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫ◊✲఍ᖺ఍ࠊᮾி㒔ࠊ5.25-26.
― 193 ―
᳃㈆┤ဢࠊ㔝ὠᐶ኱ࠊᯇỌ㐩㞝ࠊ㣤ᓥ୍ㄔ
㑇ఏᏊኚ␗ࢆྠᐃࡋࡓ branchio-oto-renal㸦BOR㸧⑕ೃ⩌ࡢ⭈⑕≧࡟㛵ࡍࡿ᳨ウ
᪥ᮏᑠඣ⭈⮚⑓Ꮫ఍Ꮫ⾡㞟఍ ➨ 50 ᅇグᛕ኱఍ࠊරᗜ┴ࠊ2015.6.18-20.
ຍ⸨⚽ᩄࠊ༡ಟྖ㑻ࠊ㕥ᮌ኱௓ࠊ▮㒊⪽ᏊࠊⱝᯘẎࠊỌ஭㑈ᩯࠊ኱཭❶Ꮚࠊᓥ⏣㈗ಙࠊ஬ᓥ
ྐ⾜ࠊᯇỌ㐔㞝ࠊゅ⏣᫭୍ࠊ⸨஭ṇேࠊຍᡃྩᏕ
ᙜ⛉࡟࠾ࡅࡿ⿵⫈እ᮶ࡢྲྀࡾ⤌ࡳ
᪥ᮏ⫈ぬ་Ꮫ఍ ➨ 1 ᅇ ⪥㬆࣭㞴⫈◊✲఍ࠊᮾி㒔᪂ᐟ༊ࠊ2015.7.11.
⣽㇂ㄔࠊ⸨ᒸṇேࠊᒸᮏ⌮ᚿࠊ᭮᰿ᓅྐࠊᯇỌ㐩㞝ࠊ㉥ᯇ࿴ᅵࠊᑠᕝ㑳ࠊᒸ㔝ᰤஅ
PENDRED ⑕ೃ⩌⑌ᝈ≉␗ⓗ iPS ⣽⬊⏤᮶ෆ⪥⣽⬊ࢆ⏝࠸ࡓ⸆๣ࢫࢡ࣮ࣜࢽࣥࢢ
➨ 36 ᅇ᪥ᮏ⅖⑕࣭෌⏕་Ꮫ఍ࠊᮾி㒔ࠊ2015.7.21-22.
⸨ᒸṇேࠊ⣽㇂ㄔࠊᯇỌ㐩㞝ࠊᑠᕝ㑳ࠊᒸ㔝ᰤஅ
MYO15A ᪂つ㑇ఏᏊኚ␗⑕౛࠿ࡽࡢ⑌ᝈ≉␗ⓗ iPS ⣽⬊ࡢᶞ❧࡜ゎᯒ
➨ 38 ᅇ ᪥ᮏ⚄⤒⛉Ꮫ኱఍ࠊරᗜ┴ࠊ2015.7.28-31.
໭ᑿᜤᏊࠊ㞴Ἴ୍ᚨࠊ༡ಟྖ㑻ࠊቑ⏣ẎࠊᯇỌ㐩㞝ࠊຍᡃྩᏕ
OPA1 㑇ఏᏊኚ␗࡟క࠺ᡂேᮇⓎ⑕ࡢ Auditory Neuropathy ࡢ⫈ຊ᳨ᰝ࡜ᖹ⾮᳨ᰝࡢ≉ᚩ
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍ࠊ㛗ᓮ┴ࠊ2015.10.7-10.
ົྎⱥᶞࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᯇỌ㐩㞝
Exome ゎᯒࢆ⏝࠸ࡓ⑕ೃ⩌ᛶ㞴⫈࡟ᑐࡍࡿཎᅉ㑇ఏᏊྠᐃࡢヨࡳ
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍ࠊ㛗ᓮ┴ࠊ2015.10.7-10.
㞴Ἴ୍ᚨࠊົྎⱥᶞࠊ༡ಟྖ㑻ࠊᆏᮏᾈ୍ࠊᯇỌ㐩㞝
㞴⫈㑇ఏᏊ LOXHD1 ࡢ᪂つኚ␗యࡢศᏊ⑓ែࡢ᳨ド
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍ࠊ㛗ᓮ┴ࠊ2015.10.7-10.
㕥ᮌἲ⮧ࠊᯇỌ㐩㞝ࠊᑠᕝ㑳ࠊᏲᮏ೔Ꮚ
୍㐣ᛶ࡟㔜⠜࡞⚄⤒⑕≧ࢆⓎ⑕ࡋࡓ Waardenburg ⑕ೃ⩌ࡢ 1 ౛
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍ࠊ㛗ᓮ┴ࠊ2015.10.7-10.
ᯇᓥྍዉࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᯇỌ㐩㞝ࠊᕤ⸨඾௦
m7445A㸼G 㑇ఏᏊኚ␗ࡀྠᐃࡉࢀࡓᗂඣ㐍⾜ᛶឤ㡢㞴⫈ࡢ㸯౛
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍ࠊ㛗ᓮ┴ࠊ2015.10.7-10.
༡ಟྖ㑻ࠊົྎⱥᶞࠊ࿴బ㔝ᾈ୍㑻ࠊᯇỌ㐩㞝
୰⪥ᖖᅾ⳦ྀ࡜៏ᛶ୰⪥⅖⣽⳦ྀࡢ 16SrRNA ⳦✀⤌ᡂゎᯒ
᪥ᮏே㢮㑇ఏᏛ఍➨ 60 ᅇ኱఍ࠊᮾி㒔ࠊ2015.10.14-17.
― 194 ―
ቑ⏣బ࿴Ꮚࠊ⮻஭ᬛᏊࠊ㭯ᒸᘯ⨾ࠊ▼ᕝ࿴௦ࠊᯇỌ㐩㞝ࠊ➉ෆ୓ᙪ
ᙜ⛉࡟࠾ࡅࡿᑠඣࡢ୧ഃேᕤෆ⪥⑕౛ࡢ᳨ウ
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
໭ᑿᜤᏊࠊᏲᮏ೔Ꮚࠊ௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᮡෆᬛᏊࠊቑ⏣బ࿴Ꮚࠊᒸᮏᗣ⚽ࠊ᳃⏣カᏊࠊ
ຍᡃྩᏕࠊᯇỌ㐩㞝
Auditory Neuropathy Spectrum Disorder ࡟࠾ࡅࡿ DPOAE ࡢ⤒㐣࡜⫈ຊ᳨ᰝ⤖ᯝ࡜ࡢ
㛵ಀ
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
Ᏹబ⨾┿୍ࠊᐑᕝ㯞⾰Ꮚࠊすᑿಙဢࠊụᅬဴ㑻ࠊ▼ᕝᾈኴ㑻ࠊᒾᓮ⪽ࠊᒸᮏ∾ேࠊᑠᕝ㑳ࠊ
ຍᡃྩᏕࠊ⇃ᕝᏕ୕ࠊᑠᶫඖࠊᆏ⏣ⱥ᫂ࠊబ⸨ᏹ᫛ࠊబ㔝⫕ࠊ᭯᰿୕༓ᙪࠊ㧗ᶫᬕ㞝ࠊṊ⏣
ⱥᙪࠊᮾ㔝ဴஓࠊෆ⸨Ὀࠊ୰ᕝᑦᚿࠊす㷂࿴๎ࠊ㔝ཱྀె⿱ࠊ⩚⸨┤ேࠊཎ᫭ࠊ⚟⏣ㅍࠊᯇỌ
㐩㞝ࠊᒣᒽ㐩ஓ
ⱝᖺⓎ⑕ᆺ୧ഃᛶឤ㡢㞴⫈ࡢ⮫ᗋⓗ≉ᚩ࡟ࡘ࠸࡚
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
すᑿಙဢࠊᐑᕝ㯞⾰Ꮚࠊụᅬဴ㑻ࠊ▼ᕝᾈኴ㑻ࠊᒾᓮ⪽ࠊᒸᮏ∾ேࠊᑠᕝ㑳ࠊຍᡃྩᏕࠊ⇃
ᕝᏕ୕ࠊᑠᶫඖࠊᆏ⏣ⱥ᫂ࠊబ⸨ᏹ᫛ࠊబ㔝⫕ࠊ᭯᰿୕༓ᙪࠊ㧗ᶫᬕ㞝ࠊṊ⏣ⱥᙪࠊᮾ㔝ဴ
ஓࠊෆ⸨Ὀࠊ୰ᕝᑦᚿࠊす㷂࿴๎ࠊ㔝ཱྀె⿱ࠊ⩚⸨┤ேࠊཎ᫭ࠊ⚟⏣ㅍࠊᯇỌ㐩㞝ࠊᒣᒽ㐩
ஓࠊᏱబ⨾┿୍
≉Ⓨᛶ୧ഃᛶឤ㡢㞴⫈ᝈ⪅࡟ᑐࡍࡿ㑇ఏᏛⓗ᳨ᰝ㹼ḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࢆ⏝࠸ࡓ᳨ᰝ㹼
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
㨣㢌Ⰻ㍜ࠊすᑿಙဢࠊụᅬဴ㑻ࠊ▼ᕝᾈኴ㑻ࠊᒾᓮ⪽ࠊᒸᮏ∾ேࠊᑠᕝ㑳ࠊຍᡃྩᏕࠊ⇃ᕝ
Ꮥ୕ࠊᑠᶫඖࠊᆏ⏣ⱥ᫂ࠊబ⸨ᏹ᫛ࠊబ㔝⫕ࠊ᭯᰿୕༓ᙪࠊ㧗ᶫᬕ㞝ࠊṊ⏣ⱥᙪࠊᮾ㔝ဴஓࠊ
ෆ⸨Ὀࠊ୰ᕝᑦᚿࠊす㷂࿴๎ࠊ㔝ཱྀె⿱ࠊ⩚⸨┤ேࠊཎ᫭ࠊ⚟⏣ㅍࠊᯇỌ㐩㞝ࠊᒣᒽ㐩ஓࠊ
Ᏹబ⨾┿୍
⮫ᗋ᝟ሗㄪᰝ⚊ࢆ⏝࠸ࡓ✺Ⓨᛶ㞴⫈ࡢ␿Ꮫㄪᰝ㹼㞴἞ᛶ⫈ぬ㞀ᐖ࡟㛵ࡍࡿㄪᰝ◊✲⌜
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
௰㔝ᩔᏊࠊ᭷ᮏ཭ᏘᏊࠊᕤ⸨඾௦ࠊᯇỌ㐩㞝
㞴⫈ࢆㄆࡵࡓඛኳᛶࢧ࢖ࢺ࣓࢞ࣟឤᰁ⑕ 14 ⑕౛ࡢ᳨ウ
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
Ᏺᮏ೔Ꮚࠊ㕥ᮌἲ⮧ࠊᑠ᳃Ꮫࠊྜྷ὾ᆂ♸ࠊᅵᶫዉࠎࠊᰗ⃝▖ࠊబ⸨⿱ᏊࠊᯇỌ㐩㞝
EDNRB 㑇ఏᏊ࣍ࣔ᥋ྜࢆ᭷ࡋࡓ࣮࣡ࣝࢹࣥࣈࣝࢢ⑕ೃ⩌ 1 ᆺࡢ 1 ౛
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
― 195 ―
ຍ⸨⚽ᩄࠊ༡ಟྖ㑻ࠊ㕥ᮌ኱௓ࠊᯇỌ㐔㞝ࠊຍᡃྩᏕ
ᙜ⛉࡟࠾ࡅࡿ⿵⫈ჾእ᮶ࡢྲྀࡾ⤌ࡳ࡜ㄢ㢟
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
బ⸨⿱Ꮚࠊᰗ⃝▖ࠊྜྷ὾ᆂ♸ࠊᅵᶫዉࠎࠊᑠ᳃ᏛࠊᯇỌ㐩㞝ࠊᏲᮏ೔Ꮚ
OTOF 㑇ఏᏊኚ␗ࢆㄆࡵࡿ Auditory Neuropathy ᑠඣࡢேᕤෆ⪥⾡ᚋ 5 ᖺホ౯
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.10.21-23.
Ọ஭㑈ᩯࠊᯇỌ㐩㞝ࠊ኱཭❶Ꮚࠊ༡ಟྖ㑻ࠊ⸨஭ṇேࠊຍᡃྩᏕ ᪂ࡓ࡞ཎᅉ㑇ఏᏊࡀྠᐃࡉࢀࡓ Waardenburg ⑕ೃ⩌ Type Ϩࡢ 1 ౛ ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ᮾி㒔ᆅ᪉㒊఍౛఍ ➨ 209 ᅇᏛ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.11.7.
༡ಟྖ㑻ࠊ▮㒊⪽ᏊࠊⱝᯘẎࠊỌ஭㑈ᩯࠊ኱཭❶Ꮚࠊᓥ⏣㈗ಙࠊ஬ᓥྐ⾜ࠊᯇỌ㐔㞝ࠊゅ⏣
᫭୍
ᙜ⛉⿵⫈ჾእ᮶࡟࠾ࡅࡿ⿵⫈ჾᣢࡕ㎸ࡳ⑕౛࡟㛵ࡍࡿ⪃ᐹ
➨ 15 ᅇ ୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ࠊ2015.12.5.
༡ ಟྖ㑻, ➉⭜ ⱥᶞ, ຍᡃ ྩᏕ
⼗∵↓ᙧᡂ␲࠸⑕౛࡟ᑐࡍࡿேᕤෆ⪥ᡭ⾡㐺ᛂ࡟ࡘ࠸࡚ࡢ⪃ᐹ
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊ㛗ᓮࠊ2015.10.10
༡ ಟྖ㑻, ົྎ ⱥᶞ, ᇼ஭ ᪂, ࿴బ㔝 ᾈ୍㑻, ᱇ ㈨Ὀ, ⏣୰ ⸨ಙ, ℧ཱྀ ဴஓ, ኱▼ ┤
ᶞ, ໭ᮧ ඘, ኱཭ ❶Ꮚ, Ọ஭ 㑈ᩯ, ஬ᓥ ྐ⾜, ᯇỌ 㐩㞝, ⸨஭ ṇே, ຍᡃ ྩᏕ
୰⪥ᖖᅾ⳦ྀ࡜៏ᛶ୰⪥⅖⣽⳦ྀࡢ 16SrRNA ⳦✀⤌ᡂゎᯒ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾிࠊ2016.5.23
༡ ಟྖ㑻, ᴮᮏ ༓ỤᏊ, ቑ⏣ Ẏ, ᑠῲ ༓⤮, ᇛ㛫 ᑗỤ, ຍᡃ ྩᏕ
⼗∵⚄⤒ᗏᙧᡂ 20 ⑕౛ࡢ⾡๓⫈ぬ཯ᛂ࣭๓ᗞᶵ⬟ࠊ⾡୰ EABRࠊ࠾ࡼࡧ⾡ᚋ⿦⏝ຠᯝ࡟㛵
ࡍࡿ᳨ウ
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾிࠊ2015.10.22
༡ ಟྖ㑻, ົྎ ⱥᶞ, ᯇỌ 㐩㞝
୰⪥ᖖᅾ⳦ྀ࡜៏ᛶ୰⪥⅖⣽⳦ྀࡢ 16SrRNA ⳦✀⤌ᡂゎᯒ
᪥ᮏே㢮㑇ఏᏛ఍ ➨ 60 ᅇ኱఍ࠊᮾிࠊ2015.10.17
㤿ሙ ඃ ࢹࢢ࢚ࣜࣥࡣ㢌㢕㒊⒴࡟ᑐࡋ࡚ EGFR-AKT ࠾ࡼࡧ IGF1R-AKT ࢆᶆⓗ࡜ࡋ࢔
࣏ࢺ࣮ࢩࢫࢆㄏᑟࡍࡿ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᖹᡂ 27 ᖺ 5 ᭶ 20 ᪥㹼5 ᭶ 23 ᪥ࠊᮾி
― 196 ―
ᒣ⃝୍ᶞ
࣓ࢳࣝ໬␗ᖖ࡟㉳ᅉࡍࡿᑠඣඛኳ␗ᖖ⑕ೃ⩌࡟࠾࠸࡚ࣄࢻࣟ࢟ࢩ࣓ࢳࣝ໬ࡀᯝࡓࡍᙺ๭
➨ 118 ᅇ᪥ᮏᑠඣ⛉Ꮫ఍ ኱㜰 2015 ᖺ 4 ᭶ 18 ᪥
ᒣ⃝୍ᶞࠊᯇཎᆂᏊࠊ㙾㞞௦ࠊ῝ぢ┿⣖ࠊ୰ᯘ୍ᙪࠊ⥴᪉໅
࣓ࢳࣝ໬␗ᖖ࡟㉳ᅉࡍࡿ Kagami-Ogata ⑕ೃ⩌࡟࠾࠸࡚ࣄࢻࣟ࢟ࢩ࣓ࢳࣝ໬ࡢᯝࡓࡍᙺ๭
ࡢゎ᫂
➨ 38 ᅇᑠඣ㑇ఏᏛ఍ ᶓ὾ 2015 ᖺ 7 ᭶ 25 ᪥
ᒣ⃝୍ᶞࠊᯇཎᆂᏊࠊ㙾㞞௦ࠊ୰ᯘ୍ᙪࠊ῝ぢ┿⣖ࠊ⥴᪉໅
IG-DMR ࡢ㧗࣓ࢳࣝ໬࡟㉳ᅉࡍࡿ Kagami-Ogata ⑕ೃ⩌࡟࠾ࡅࡿࣄࢻࣟ࢟ࢩ࣓ࢳࣝ໬ࡢ᥈
⣴
➨ 49 ᅇ᪥ᮏᑠඣෆศἪᏛ఍ ᮾி 2015 ᖺ 10 ᭶ 9 ᪥
Yamazawa K, Matsubara K, Kagami M, Nakabayashi K, Hata K, Fukami M, Ogata T
Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by
hypermethylation of imprinting control regions
ASHG 2015 Annual Meeting, Baltimore, 2015.10.11
ᒣ⃝୍ᶞࠊᯇཎᆂᏊࠊ㙾㞞௦ࠊ୰ᯘ୍ᙪࠊ⛙೺୍㑻ࠊ῝ぢ┿⣖ࠊ⥴᪉໅
࢖ࣥࣉࣜࣥࢸ࢕ࣥࢢㄪ⠇㡿ᇦࡢ㧗࣓ࢳࣝ໬࡟㉳ᅉࡋࡓ Kagami-Ogata ⑕ೃ⩌࡟࠾ࡅࡿࣄࢻ
ࣟ࢟ࢩ࣓ࢳࣝ໬ࡢ᥈⣴
᪥ᮏே㢮㑇ఏᏛ఍➨ 60 ᅇ኱఍ ᮾி 2015 ᖺ 10 ᭶ 15 ᪥
Pioche M, Rivory J, Aguero G, Guillaud O, O'Brien M, Uraoka T, Yahagi N, Ponchon T.
New isolated bovine colon model dedicated to colonic ESD hands-on training:
development and first evaluation. Digestive Disease Week 2015, Washington D.C. /USA,
May 2015
Fujimoto A, Ochiai Y, Goto O, Nishizawa T, Nakamura R, Maehata T, Kinoshita S,
Sagara S, Uraoka T, Yahagi N.
Efficacy of a 2% rebamipide solution as a novel submucosal injection agent for gastric
endoscopic submucosal dissection. Digestive Disease Week 2015, Washington D.C. /USA,
May 2015
Uraoka T, Fujimoto A, Ochiai Y, Goto O, Kawahara Y, Hori K, Masayuki S, Yahagi Y.
High pressure carbon dioxide submucosal injection in endoscopic submucosal dissection.
Digestive Disease Week 2015, Washington D.C. /USA, May 2015
― 197 ―
Takatori Y, Kato M, Suzuki M, Abe K, Hirata T, Takada Y, Naruse T, Takabayashi K,
Kikuchi M, Fujiyama Y, Takahashi M, Uraoka T.
History of gastro-duodenal ulcer as an independent predictor for requirement of
endoscopic intervention for non-variceral upper gastrointestinal bleeding. Digestive
Disease Week 2015, Washington D.C. /USA, May 2015
Sato M, Kato M, Suzuki M, Abe K, Takada Y, Hirata T, Takatori Y, Naruse T,
Takabayashi K, Kikuchi M, Fujiyama Y, Takahashi M, Uraoka T.
Should all patients with colonic diverticular hemorrhage undergo urgent colonoscopy?
Digestive Disease Week 2015, Washington D.C. /USA, May 2015
Uraoka T, Tanaka S, Saito Y, Matsumoto T, Saito S, Oka S, Matsuda T, Moriyama T,
Ogata H, Yahagi N, Tajiri H, Ishikawa H. Diagnostic value of extra-wide-angle-view
colonoscope in the aAdenoma detection: a multicenter randomized controlled trial.
Digestive Disease Week 2015, Washington D.C. /USA, May 2015
Uraoka T, Fujimoto A, Ochiai Y, Goto O, Maehata T, Nishizawa T, Kawahara Y, Hori K,
Kato M, Shimoda M, Yahagi N.
A novel high-pressure carbon dioxide submucosal injection technique in endoscopic
submucosal dissection. United Enropean Gastroenterology 2015, Barcelona / Spain, Oct
2015
Kato M, Sakaguchi E, Abe K, Takada Y, Hirata T, Banno S, Wada M, Takatori T,
Kinoshita S, Kikuchi H, Takabayashi K, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M,
Ohishi T, Uraoka T. Screening colonoscopy for subjects older than 85 years old. United
Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
Wada M, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y, Hirata T,
Takatori Y, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M,
Uraoka T.
The history of colonic diverticular hemorrhage and colonoscopic hemostasis are
independent predictors for reccurent hemorrhage. United Enropean Gastroenterology
2015, Barcelona / Spain, Oct 2015
Hirata T, Uraoka T, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y,
Takatori Y, Wada M, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y,
Suzuki M, Ohishi T.
Endoscopic management for sigmoid volvulus : Should we perform endoscopic detorsion
all cases? United Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
― 198 ―
Takatori Y, Kato M, Sakaguchi E, Ishibashi Y, Banno S, Abe K, Takada Y, Hirata T, Wada
M, Kinoshita S, Takabayashi, Kikuchi M, Kikuchi M, Fujiyama Y, Suzuki M, Uraoka T.
History of gastro-duodenal ulcer is an independent predictor for requirement of
endoscopic hemostasis for non-variceral upper gastrointestinal bleeding. United
Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
Maehata T, Uraoka T, Goto O, Akimoto T, Sagara S, Ochiai Y, Fujimoto A, Nishizawa T,
Yahagi N.
Varidity of endoscopic submucosal dissection for colorectal T1 (submucosal invation)
cancer. United Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
Ochiai Y, Akimoto T, Sagara S, Maehata T, Fujimoto A, Nakamura R, Nishizawa T, Goto
O, Uraoka T, Yahagi N.
Clinical outcome of endoscopic submucosal dissection for superficial duodenal neoplasm
in 60 lesions. United Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
Pioche M, Rivory J, Nishizawa T, Uraoka T, Lienhart I, Ponchon T, Yahagi N.
Randomized comparative evaluation of an ESD self-learning software in France and
Japan. United Enropean Gastroenterology 2015, Barcelona / Spain, Oct 2015
Fujimoto A, Goto O, Akimoto T, Maehata T, Ochiai Y, Nishizawa T, Nakamura R, Sagara
S, Akimoto T, Shimoda M, Uraoka T, Yahagi N.
Evaluation of the speed and quality of gastric ulcer healing after ESD using 2%
rebamipide solution as a novel submucosal injection material. United Enropean
Gastroenterology 2015, Barcelona / Spain, Oct 2015
Kato M, Nishida T, Yamamoto T, Kitamura S, Yamada T, Egawa S, Komori M, Kawai N,
Nishihara A, Nakanishi F, Nakahara M, Ogiyama H, Mukai A, Hayashi Y, Tsujii M,
Takehara T
Severe atrophic gastritis is a significant risk factor of metachronous multiple gastric
cancer: A Multicentre Retrospective Cohort Study by the Osaka Gut Forum. United
European Gastroenterology Week 2015, Barcelona / Spain, Oct 2015
Masahiro Kikuchi, Rumiko Umeda, Kota Tsuruya, Hirokazu Shiozawa, Miho Kikuchi,
Masahiko Takahashi, Yoshinori Horie, Yasuhiro Nishizaki
Diagnostic accuracy for non-alcoholic fatty liver disease (NAFLD) with controlled
attenuation parameter (CAP) measured by transient elastography
The 66th American Association for the Study of the Liver San Francisco(USA),
2015.11.17
― 199 ―
Yasuhiro Nishizaki, Chizumi Yamada, Noriaki Kishimoto, Nobushige Yukumatsu,
Hirokazu Shiozawa, Norihito Watanabe, Rumiko Umeda, Masahiro Kikuchi, Takanori
Kanai, Naoaki Tshii
Ferritin derived oxidative stress is a risk for liver damage even within reference range
in male
The 10th World Congress for Microcirculation, Kyoto, 2015.9.25
Habu, N., Y. Imanishi, K. Kameyama, M. Shimoda, Y. Tokumaru, K. Sakamoto, R.
Fujii, S. Shigetomi, K. Otsuka, Y. Sato, Y. Watanabe, H. Ozawa, T. Tomita, M. Fujii
and K. Ogawa (2015). "Expression of Oct3/4 and Nanog in the head and neck squamous
carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II
oral tongue squamous cell carcinoma." BMC Cancer 15: 730.
Kunio Mizutari Endoscopic Tympanoplasty, The initial difficulties.
1st World Congress on Endoscopic Ear Surgery, Dubai, UAE, 2015.4.19
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ, 㧗
ᯘ㤾, ⳥ụ┿኱, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ.
⫶༑஧ᣦ⭠₽⒆ࡢ᪤ ࡣୖ㒊ᾘ໬⟶ฟ⾑ᝈ⪅࡟࠾࠸࡚ෆど㙾ⓗṆ⾑⾡ࡢ⊂❧ࡋࡓ༴㝤ᅉᏊ
࡛࠶ࡿ. ➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍, ᮾி㒔᪂ᐟ༊, 2015.2
ᚋ⸨ ಟ, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ୗ⏣ᑗஅ, ᯇ⏣ 㐩㞝, బࠎᮌ ᇶ, ⴠྜᗣ฼, ᇼ஭ᇛ୍ᮁ, ᾆ
ᒸಇኵ, ᕝஂಖ༤ᩥ, ➉ෆ⿱ஓ, ໭ᕝ㞝ග, ▮స┤ஂ.
SM ⫶⒴࡟ᑐࡍࡿෆど㙾ⓗ඲ᒙษ㝖⾡࡟࠾ࡅࡿ㐺ษ࡞ษ㞳᩿➃㊥㞳ࡢ᳨ウ. ➨ 11 ᅇ᪥ᮏᾘ
໬⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍, ᮾி㒔᪂ᐟ༊, 2015.2
ᇼ ᆂ௓, ᾆᒸಇኵ, ཎ⏣㤾ኴ, ᮾ ⋹἞, Ἑཎ⚈ᮁ, ᒸ⏣⿱அ, ▮స┤ஂ ᒣᮏ࿴⚽.
࣮ࣛࢽࣥࢢ࣮࢝ࣈ࡟ᛂࡌࡓ኱⭠ ESD ᅔ㞴⑕౛ࡢண ᅉᏊ࡟㛵ࡍࡿ᳨ウ. ➨ 11 ᅇ᪥ᮏᾘ໬
⟶Ꮫ఍⥲఍Ꮫ⾡㞟఍, ᮾி㒔᪂ᐟ༊, 2015.2
㣬ᮏဴර, ᚋ⸨ ಟ, ᮌୗ ⪽, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ᾆᒸ
ಇኵ, ⥴᪉ᬕᙪ, ᆏᮏ㛗㐓, ▮స┤ஂ.
ᙜ㝔࡛῝㐩ᗘデ᩿ࡀᅔ㞴࡛࠶ࡗࡓ᪩ᮇ⫶⒴ෆど㙾἞⒪⑕౛ࡢ᳨ウ. ➨ 11 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍
⥲఍Ꮫ⾡㞟఍, ᮾி㒔᪂ᐟ༊, 2015.2
๓⏿ᛅ㍤, ᚋ⸨ ಟ, ➉ෆ⿱ஓ, 㣬ᮏဴර, ᮌୗ ⪽, ┦Ⰻㄔ஧, す⃝ಇᏹ, ⸨ᮏ ឡ, ⴠྜᗣ
฼, ᾆᒸಇኵ, ➉ෆ⿱ஓ, ໭ᕝ㞝ග, ▮స┤ஂ.
NEWS ࡜ࢭࣥࢳࢿࣝࣜࣥࣃ⠇ࢼࣅࢤ࣮ࢩࣙࣥᡭ⾡ࡢ⼥ྜ࡟ࡼࡿ᪂ࡋ࠸⫶⒴⦰ ᑠᡭ⾡. ➨
87 ᅇ᪥ᮏ⫶⒴Ꮫ఍Ꮫ⾡㞟఍, 2015 3
― 200 ―
ᾆᒸಇኵ, ຍ⸨ඖᙪ, ▮స┤ஂ㸬
኱⭠ ESD ἞⒪ᅔ㞴౛࡟ᑐࡍࡿ࢔ࣉ࣮ࣟࢳ ɆDual knifeɆ ➨ 101 ᅇ᪥ᮏᾘ໬ჾᏛ఍Ꮫ⾡
㞟఍, ᐑᇛ┴௝ྎᕷ, 2015.4
ຍ⸨ඖᙪ, ኱▼ᓫ, ᾆᒸಇኵ㸬
↓⑕≧ࡢ 85 ṓ௨ୖࡢ㉸㧗㱋⪅࡟኱⭠ෆど㙾᳨ᰝࡣᚲせ࠿㸽 ➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍
⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
⸨ᮏឡ, ᾆᒸಇኵ, ▮స┤ஂ㸬
Dual Red Imaging ࡢ⌧≧࡜ᒎᮃ㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ,
2015.5
ⴠྜᗣ฼, ᾆᒸಇኵ, ▮స┤ஂ㸬
┤⭠⫠㛛㒊⭘⒆࡟࠾ࡅࡿෆど㙾἞⒪ᅔ㞴⑓ኚ࡟ᑐࡍࡿ ESD㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ
఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
ᾆᒸಇኵ, ᚋ⸨ಟ, ▮స┤ஂ㸬
⫶ ESD ᚋ₽⒆࡟ᑐࡍࡿ᪂つ⮬ᕫ⤌⧊໬࣌ࣉࢳࢻỈ⁐ᾮࡢ⮫ᗋᛂ⏝ࡢྍ⬟ᛶ㸬➨ 89 ᅇ᪥ᮏ
ᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
๓⏿ᛅ㍤, ᾆᒸಇኵ, 㣬ᮏဴර, ᮌୗ⪽, ┦Ⰻㄔ஧, బࠎᮌᇶ, す⃝ಇᏹ, ᚋ⸨ಟ, ⸨ᮏឡ,
ⴠྜᗣ฼, ▮స┤ஂ㸬
᪩ᮇ኱⭠⒴ pT1(SM)⑕౛࡟ᑐࡍࡿ ESD ࡢጇᙜᛶ㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ
▱┴ྡྂᒇᕷ, 2015.5
┦Ⰻㄔ஧, ᚋ⸨ಟ, 㣬ᮏဴර, ᮌୗ⪽, ⸨ᮏឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, す⃝ಇᏹ, ᾆᒸಇኵ,
⥴᪉ᬕᙪ, ▮స┤ஂ㸬
ᙜ⛉࡟࠾ࡅࡿࢹ࢟ࢧ࣓ࢹࢺ࣑ࢪࣥ㙠㟼ୗ㧗㞴ᗘ ESD ࡢᐇ㝿㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ
఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ, 㧗ᯘ
㤾, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ㸬
⫶༑஧ᣦ⭠₽⒆ࡢ᪤ ࡣୖ㒊ᾘ໬⟶ฟ⾑ᝈ⪅࡟࠾ࡅࡿෆど㙾ⓗṆ⾑⾡ࡢせྰ࡟ᑐࡍࡿ⊂❧
ࡋࡓண ᅉᏊ࡛࠶ࡿ㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
ᮌୗ ⪽, す⃝ಇᏹ, 㣬ᮏဴර, ┦Ⰻㄔ஧, ᚋ⸨ಟ, ๓⏿ᛅ㍤, ⸨ᮏឡ, ⴠྜᗣ฼, ୰ᮧ⌮ᜨ
Ꮚ, ᾆᒸಇኵ, ▮స┤ஂ㸬
༑஧ᣦ⭠⭘⒆࡟ᑐࡍࡿෆど㙾἞⒪࡜἞⒪ᡓ␎ࡢ⌧≧㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍,
ឡ▱┴ྡྂᒇᕷ, 2015.5
― 201 ―
బ⸨㐨Ꮚ, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ဴ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ
㤾, ⳥ụ┿኱, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ㸬
኱⭠᠁ᐊฟ⾑඲౛࡟ෆど㙾ⓗṆ⾑⾡ࢆ᪋⾜ࡍ࡭ࡁ࠿㸽㹼෌ฟ⾑ࣜࢫࢡᅉᏊ࡟㛵ࡍࡿᚋ᪉ど
ⓗࢥ࣮࣍ࢺ◊✲㹼㸬➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
㣬ᮏဴර, ᚋ⸨ಟ, ᮌୗ⪽, ┦Ⰻㄔ஧, ⸨ᮏឡ, ⴠྜᗣ฼, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ᳜ᮌಙỤ,
ᾆᒸಇኵ, ㎮ཱྀ⠜ᚿ, ୕Ꮿ୍ᫀ, ᆏᮏ㛗㐓, ▮స┤ஂ㸬
H.pylori 㝖⳦ᚋ⫶⒴࠾ࡼࡧ⫼ᬒ⢓⭷࡟⏕ࡌࡿ⤌⧊Ꮫⓗኚ໬࡜ෆど㙾デ᩿ࡢ᳨ウ㸬
㸬➨ 89 ᅇ
᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
ᴿᾈ⾜, ཎ⏣㤾ኴ, ᾆᒸಇኵ, 㧗ᔱᚿಖ, ஭ཱྀಇ༤, ➉஭኱௓, ᮡཎ㞝⟇, ༙஭᫂᪥㤶, 㧗ཎ
ᨻᏹ, ᑠᯘἋ௦, 㧗ᶫ⣴┿, 㰺⸨ಇ௓, ᇼ஭ᇛ୍ᮁ, ᮾ⋹἞, ᖹᒸబつᏊ, ᒸ⏣⿱அ, ᒣᮏ࿴
⚽㸬
ෆど㙾ⓗ⢓⭷ୗᒙ๤㞳⾡(ESD)ࡀ᪋⾜ࡉࢀࡓ኱⭠ T1(SM)⒴ࡢ἞⒪ᡂ⦼࡜ணᚋࡢ᳨ウ㸬➨ 89
ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍, ឡ▱┴ྡྂᒇᕷ, 2015.5
ᾆᒸಇኵ, ▮స┤ஂ㸬
኱⭠⒴ࢫࢡ࣮ࣜࢽࣥࢢ࡟࠾ࡅࡿ㏆ᮍ᮶ࡢ኱⭠ෆど㙾ࣔࢲࣜࢸ࢕࣮㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆ
ど㙾Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
㧗ᯘ 㤾, 㜿㒊ᆂ୍㑻, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, ຍ⸨ඖᙪ, ⳥ụ
⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ㸬
኱⭠ ESD ࡟࠾ࡅࡿᡭᢏⓗᅔ㞴⑕౛ࠊ⾡ᚋ⊃✽⑕౛࡟ᑐࡍࡿ᳨ウ㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど
㙾Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
⸨ᮏ ឡ,ⴠྜ ᗣ฼,ᚋ⸨
ಟ, ๓⏿ᛅ㍤, ᇼ஭ᇛ୍ᮁ, 㧗ᯘ 㤾, 㣬ᮏဴර, ┦Ⰻㄔ஧, ᮌୗ
⪽, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ᾆᒸಇኵ, ▮స ┤ஂ.
Dual Red Imaging ࡢ⌧≧࡜ᒎᮃ㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦
⏣༊, 2015.6
ᖹ⏣ ဴ, ຍ⸨ ඖᙪ, 㜿㒊ᆂ୍ᮁ
㧗⏣♸᫂, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾, ⳥
ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, 㧗ᶫṇᙪ, ᾆᒸಇኵ㸬
S ≧⤖⭠᤬㌿⑕࡟ᑐࡍࡿෆど㙾ⓗᩚ᚟ࡢព⩏࡟ࡘ࠸࡚ࡢ᳨ウ㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾
Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
ⴠྜᗣ฼, 㣬ᮏဴර, ᮌୗ ⪽, ┦Ⰻㄔ஧, ๓⏿ᛅ㍤, ⸨ᮏ ឡ, ᚋ⸨ ಟ, ୰ᮧ⌮ᜨᏊ, す⃝
ಇᏹ, ᾆᒸಇኵ, ▮స┤ஂ㸬
ᙜ㒊㛛࡟࠾ࡅࡿ༑஧ᣦ⭠ ESD ࡢᏳ඲ᛶ࠾ࡼࡧ᭷ຠᛶࡢホ౯㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ
఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
― 202 ―
❑⃝㝧Ꮚ, 㧗ᯘ 㤾, 㧗ྲྀ♸స, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨ 㐨Ꮚ, ᡂ℩ᬛᗣ, ຍ
⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, 㰺⸨ඃᏊ, ᒣᮏ⣪つᏊ, ᮧ⏣᭷ஓ, ๓ᓥ᪂ྐ, 㧗ᶫṇᙪ,బ⸨
཭㝯, ᾆᒸಇኵ㸬
ከ⮚ჾ㌿⛣ࢆ᮶ࡋࡓ㣗㐨ཎⓎ↓Ⰽ⣲ᛶᝏᛶ㯮Ⰽ⭘ࡢ 1 ౛㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍
㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
㣬ᮏဴර, ᚋ⸨ ಟ, 㭯⏣ 㞞ኈ, ᮌୗ ⪽, ┦Ⰻㄔ஧, ⸨ᮏ ឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, す⃝ಇ
ᏹ, ୰ᮧ⌮ᜨᏊ, ᾆᒸಇኵ, ⥴᪉ᬕᙪ, டᒣ㤶⧊, ▮స ┤ஂ㸬
ESD ࡛᏶඲ษ㝖ࡉࢀࡓ SM ῝㒊ᾐ₶⒴ࡀ▷ᮇ㛫࡛ᒁᡤ෌Ⓨࡋࡓ 1 ౛㸬➨ 100 ᅇ᪥ᮏᾘ໬ჾ
ෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
┦Ⰻㄔ஧, ᚋ⸨ ಟ, 㣬ᮏဴර, ᮌୗ ⪽, ⸨ᮏ ឡ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, す⃝ಇᏹ, ᾆᒸಇ
ኵ, ▮స┤ஂ㸬
ESD ἞⒪㏵୰ࡼࡾࢹࢡࢫ࣓ࢹࢺ࣑ࢪࣥࢆᑟධࡋⰋዲ࡞㙠㟼ࡀᚓࡽࢀࡓ 2 ⑕౛㸬➨ 100 ᅇ᪥
ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍, ᮾி㒔༓௦⏣༊, 2015.6
㧗⏣♸᫂, ຍ⸨ඖᙪ, 㜿㒊ᆂ୍㑻, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾, ⳥ụ
⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, 㧗ᶫṇᙪ, ᾆᒸಇኵ㸬
ᑠ⭠࢔ࢽࢧ࢟ࢫ⑕ࡢ⮫ᗋീ࡟ࡘ࠸࡚ࡢ᳨ウ㸬Japan Digestive Disease Week, රᗜ┴࣭⚄ᡞ
ᕷ, 2015. 10
⳥ụ┿኱, すᓮὈᘯ, ᡂ℩ᬛᗣ, 㧗ᯘ 㤾, ຍ⸨ඖᙪ, ⳥ụ⨾✑, ⸨ᒣὒ୍, ᾆᒸಇኵ, 㧗ᶫ
ṇᙪ, ᒣᓊ⏤ᖾ, ᇼỤ⩏๎, ຍ⸨┾୕, 㔠஭㝯඾㸬
CAP(Controlled Attenuation Parameter)┦㛵࣐࣮࣮࢝ࡢ᳨ウ࡜㸪࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࣭㠀
࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈࡢ㚷ู㸬Japan Digestive Disease Week, රᗜ┴࣭⚄ᡞᕷ, 2015,
10
⸨ᮏ ឡ, ୗ⏣ᑗஅ, す⃝ಇᏹ, ୰ᮧ⌮ᜨᏊ, ⴠྜᗣ฼, ๓⏿ᛅ㍤, ᚋ⸨ ಟ, ┦Ⰻㄔ஧, ᮌୗ
⪽, 㣬ᮏဴර, ᾆᒸಇኵ, ▮స┤ஂ㸬
඲ᒙษ㝖᫬௦ࡢ᪩ᮇ⫶⒴⠊ᅖデ᩿ - ഃ᪉ఙᒎ㊥㞳࡟㛵ࡍࡿ⑓⌮Ꮫⓗ᳨ウ㸬Japan Digestive
Disease Week, රᗜ┴࣭⚄ᡞᕷ, 2015. 10
ຍ⸨ඖᙪ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, 㧗ྲྀ♸స, ᡂ℩ᬛᗣ, ⳥ụᘯே, 㧗
ᯘ 㤾, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ኱▼ ᓫ, ᾆᒸಇኵ㸬
㉸㧗㱋⪅࡟ᑐࡍࡿ኱⭠ෆど㙾᳨ᰝࡢ㐺ᛂ࡟ࡘ࠸࡚ࡢ᳨ウ㸬Japan Digestive Disease Week,
රᗜ┴࣭⚄ᡞᕷ, 2015. 10
┦Ⰻㄔ஧, ᚋ⸨ ಟ, 㣬ᮏဴර, ⸨ᮏ ឡ, ๓⏿ᛅ㍤, ⴠྜᗣ฼, す⃝ಇᏹ, ᾆᒸಇኵ, ▮స┤
ஂ㸬
኱⭠ ESD ᅔ㞴⑕౛࡟࠾ࡅࡿࣂ࣮ࣝࣥෆど㙾ࡢ᭷⏝ᛶࡢ᳨ウ㸬Japan Digestive Disease
Week, රᗜ┴࣭⚄ᡞᕷ, 2015. 10
― 203 ―
㜿㒊ᆂ୍ᮁ, ⳥ụ┿኱, ᮌୗ ⪽, 㧗ᯘ 㤾, ຍ⸨ඖᙪ, ⳥ụ⨾✑, ⸨ᒣὒ୍, ᾆᒸಇኵ.
࢔ࣝࢥ࣮ࣝᛶ៏ᛶ⮅⅖࡟ࡼࡿ⮅ᛶ⭡Ỉ࡟ᑐࡋ࡚࢜ࢡࢺࣞ࢜ࢳࢻ㓑㓟ሷࡀዌຌࡋࡓ 1 ౛. ➨
50 ᅇ࢔ࣝࢥ࣮࣭ࣝ⸆≀౫Ꮡ㛵㐃Ꮫ఍ྜྠᏛ⾡⥲఍. රᗜ┴࣭⚄ᡞᕷ, 2015. 10
㧘ᯘ 㤾ࠊᆏཱྀᜨ⨾ࠊ㜿㒊ᆂ୍ᮁࠊ㧗⏣♸᫂ࠊᖹ⏣ ဴࠊక㔝⦾㞝ࠊ࿴⏣㐨Ꮚࠊ㧗ྲྀ♸సࠊ▼
ᶫᗣ๎ࠊᮌୗ ⪽ࠊ⳥ụ⨾✑ࠊຍ⸨ඖᙪࠊ⳥ụ┿኱ࠊ⸨ᒣὒ୍ࠊᾆᒸಇኵ㸬
☜ᐇ࡞ Cold snare polypectomy ࢆᛕ㢌࡟⨨࠸ࡓࢫࢿ࢔ࡢ㑅ᢥ㸬᪥ᮏ኱⭠᳨ᰝᏛ఍㸬ᮾி㒔
༓௦⏣༊, 2015. 11
ᖹ⏣ ဴ, ⳥ụ┿኱, ᆏཱྀ᝴ᐇ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗ྲྀ♸స, ᮌ
ୗ ⪽, 㧘ᯘ 㤾, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ㸬
ᙜ㝔࡟࠾ࡅࡿ⫢ᛶ⭡Ỉ࡟ᑐࡍࡿࢺࣝࣂࣉࢱࣥᑟධ㸬➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍, ᮾி㒔
ୡ⏣㇂༊, 2015. 12
㜿㒊ᆂ୍㑻, ⳥ụ┿኱, ᆏཱྀ᝴ᐇ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗ྲྀ♸స, ᮌ
ୗ ⪽, 㧘ᯘ 㤾, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ㸬
ERCP(ෆど㙾ⓗ㏫⾜ᛶ⮅⫹⟶㐀ᙳ)࡟࠾ࡅࡿ⮅⟶ࢫࢸࣥࢺࡢ᭷⏝ᛶ㸬➨ 15 ᅇୡ⏣㇂༊་ᖌ
఍་Ꮫ఍, ᮾி㒔ୡ⏣㇂༊, 2015. 12
క㔝⦾㞝, 㧘ᯘ 㤾, ᆏཱྀ᝴ᐇ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, 㧗ྲྀ♸స, ᮌ
ୗ ⪽, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ⓑ▼῟୍, ᾆᒸಇኵ㸬
ᙜ㝔࡛ෆど㙾ⓗ⢓⭷ୗᒙ๤㞳⾡ࢆ᪋⾜ࡋࡓ Barrett ⭢⒴ࡢ᳨ウ㸬➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་
Ꮫ఍, ᮾி㒔ୡ⏣㇂༊, 2015. 12
ຍ⸨ඖᙪ, ☾㒊 㝧, ᆏཱྀ᝴ᐇ, 㧘ᯘ 㤾, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ࿴⏣㐨Ꮚ, క㔝⦾㞝, 㧗
ྲྀ♸స,ᮌୗ ⪽, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ㸬
ୖ㒊ᾘ໬⟶⭘⒆࡟ᑐࡍࡿ⭡⭍㙾ෆど㙾ྜྠᡭ⾡(LECS)࡟ࡼࡿప౵く἞⒪㸬➨ 15 ᅇୡ⏣㇂
༊་ᖌ఍་Ꮫ఍, ᮾி㒔ୡ⏣㇂༊, 2015. 12
㧗ྲྀ♸స, ຍ⸨ඖᙪ, 㕥ᮌ㞞அ, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, బ⸨㐨Ꮚ, ᡂ℩ᬛᗣ, 㧗
ᯘ㤾, ⸨ᒣὒ୍, 㧗ᶫṇᙪ, ᾆᒸಇኵ㸬
ESD ࡢᬑཬࡣෆど㙾ⓗṆ⾑⾡࡟࡞࡟ࢆࡶࡓࡽࡋࡓ࠿㸬➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍, ᮾி
㒔ୡ⏣㇂༊, 2015. 12
క㔝⦾㞝, 㧘ᯘ 㤾, ᆏཱྀᜨ⨾, 㜿㒊ᆂ୍ᮁ, 㧗⏣♸᫂, ᖹ⏣ ဴ, ࿴⏣㐨Ꮚ, 㧗ྲྀ♸స, ▼
ᶫᗣ๎,ᮌୗ ⪽, ⳥ụ⨾✑, ຍ⸨ඖᙪ, ⳥ụ┿኱, ⸨ᒣὒ୍, ᾆᒸಇኵ.
NBI ే⏝ᣑ኱ほᐹ࠾ࡼࡧ㉸㡢Ἴෆど㙾ࡀ῝㐩ᗘデ᩿࡟᭷⏝࡛࠶ࡗࡓ 0-IIc㸩Is ᆺ㣗㐨⒴ࡢ୍
౛. ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍. ᮾி㒔༓௦⏣༊, 2015.12
― 204 ―
㧗⏣♸᫂, ຍ⸨ඖᙪ, ᆏཱྀ᝴⨾, 㜿㒊ᆂ୍ᮁ, ᖹ⏣ ဴ, 㧗ྲྀ♸స, క㔝⦾㞝, ࿴⏣㐨Ꮚ, ᮌ
ୗ ⪽, 㧗ᯘ 㤾, ⳥ụ⨾✑, ⳥ụ┿኱, ⸨ᒣὒ୍, 㕥ᮌ㞞அ, ᾆᒸಇኵ.
⭢⒴ᡂศࡀΰᅾࡋࡓ㣗㐨⫶᥋ྜ㒊ཎⓎ⚄⤒ෆศἪ⒴ࡢ 1 ๗᳨౛. ᪥ᮏᾘ໬ჾ⑓Ꮫ఍➨ 337
ᅇ㛵ᮾᨭ㒊౛఍, ᮾி༓௦⏣༊, 2015.12
ఀᮾఙ๛, ┦㤿ᓫᏹ, ጒᑿ⪽⨾, ☾㒊⩏᠇, ᆏཱྀ᝴⨾, ⳥ụ┿኱
ྤ⾑࡛Ⓨ⑕ࡋࡓ Budd-Chiari ⑕ೃ⩌ࡢ୍౛
ᮾி࢔ࣥࢠ࣭࢜㹇㹔㹐఍ࠊ ᮾிࠊ2015.12.10
᪂ᓥ኱㍜, ᐑཎ᫂㔛, ᶲ ᭸⨾, 㛗㇂㒊ࡺࡾ, 㜿㒊ᆂ୍ᮁ, ⳥ụ⨾✑, ⳥ụ┿኱
ᙜ㝔࡟࠾ࡅࡿ⫢⮚⑓ᩍᐊࡢྲྀࡾ⤌ࡳ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍, ᮾி㒔ୡ⏣㇂༊, 2015. 12
ᇼỤ⩏๎㸪ᾏ⪁἟ᾈ฼㸪୰ᮏఙᏹ㸪⳥ụ┿኱㸪㔠஭㝯඾
ᮏ㑥࡟࠾ࡅࡿ࢔ࣝࢥ࣮ࣝᛶ⫢⅖ࡢᐇែɆ2013 ᖺᗘࡢ⑕౛ࡢゎᯒɆ
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
ᱵ⏣⍠⨾Ꮚ㸪ሷ⃝ᏹ࿴㸪⳥ụ┿኱㸪すᓮὈᘯ
࢔ࣝࢥ࣮ࣝᛶ⫢◳ኚࡢ㞴἞ᛶ⭡Ỉ࡟ᑐࡋ⭡Ỉ✸่࡜ CART㸦Cell-free and Concentrated
AscitesReinfusion Therapy㸧ࢆే⏝ࡋⰋዲ࡞⤖ᯝࢆᚓࡓ 2 ⑕౛
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
⳥ụ┿኱㸪ᇼỤ⩏๎㸪෠⏣ㅬ࿃㸪ᱵ⏣⍠⨾Ꮚ㸪㭯㇂ᗣኴ㸪ሷ⃝ᏹ࿴㸪すᓮὈᘯ㸪⳥ụ⨾✑㸪
㧗ᶫṇᙪ㸪㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘኱ࡢ㐃㛵ᛶ࡟㛵
ࡍࡿ᳨ウ
➨ 41 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍ࠊឡ▱┴ྡྂᒇᕷࠊ2015.12
ᇼỤ⩏๎㸪⳥ụ┿኱㸪㔠஭㝯඾
ෆ⛉་ࡢ❧ሙ࠿ࡽࡢ࢔ࣝࢥ࣮ࣝ἞⒪࡟࠾ࡅࡿ་⒪㐃ᦠ࡜ᚰ⌮♫఍ⓗ἞⒪
➨ 50 ᅇ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㸪රᗜ௳⚄ᡞᕷ㸪2015.10
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ෠⏣ㅬ࿃ࠊᱵ⏣⍠⨾Ꮚࠊ㭯㇂ᗣኴࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊ⳥ụ⨾
✑ࠊ㧗ᶫṇᙪࠊ㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘ࡢ┦㛵ᛶ
➨ 50 ᅇ᪥ᮏ࢔ࣝࢥ࣮࣭ࣝ⸆≀་Ꮫ఍㸪රᗜ௳⚄ᡞᕷ㸪2015.10
― 205 ―
⳥ụ┿኱ࠊすᓮὈᘯࠊᮌୗ⪽ࠊᡂ℩ᬛᗣࠊ㧗ᯘ㤾ࠊຍ⸨ඖᙪࠊ⳥ụ⨾✑ࠊ⸨ᒣὒ୍ࠊᾆᒸ
ಇኵࠊ㧗ᶫṇᙪࠊᒣᓊ⏤ᖾࠊᇼỤ⩏๎ࠊຍ⸨┾୕ࠊ㔠஭㝯඾
CAP(Controlled Attenuation Parameter)┦㛵࣐࣮࣮࢝ࡢ᳨ウ࡜࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࣭㠀
࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈࡢ㚷ู
➨ 23 ᅇ Japan Digestive Disease Weekࠊᮾிࠊ 2015.10
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊᒣᓊ⏤
ᖾࠊຍ⸨┾୕ࠊ㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ࡜㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⑌ᝈ࡟࠾ࡅࡿ⫢◳ᗘ࡜⭁⭘ࡢ㛵ಀ
➨ 22 ᅇ᪥ᮏ㛛⬦ᅽஹ㐍⑕Ꮫ఍ せᮃ₇㢟ࠊᶓ὾ࠊ 2015.9.11
⳥ụ┿኱, 㧗ᯇ༓⧊, 㕥ᮌᰤ㔛Ꮚ, ㏆⸨┿⃈, ᒣ⏣༓✚, ᓊᮏ᠇᫂, ᱵ⏣⍠⨾Ꮚ ,㭯㇂ᗣኴ,
ሷ⃝ᏹ࿴, すᓮὈᘯ, ⳥ụ⨾✑, 㧗ᶫṇᙪ, 㔠஭㝯඾
ே㛫ࢻࢵࢡ࡛ࡢ⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡࣭⬡⫫⫢㝧ᛶ⋡ࡢゎᯒ࡜ࠊFibroscan ࢹ࣮
ࢱࡢ᳨ウ
➨㸰ᅇ⫢⮚࡜⢾ᒀ⑓ࠊ௦ㅰ◊✲఍ࠊᒣཱྀ┴ୗ㛵ᕷࠊ 2015.5.23
ᓊᮏ᠇᫂ࠊᒣ⏣༓✚ࠊ➉⏣㯞⨾ࠊᑿᙧ⌔ᜨࠊ㯮⏣ᜨ⨾Ꮚࠊ⳥ụ┿኱ࠊ㇂㔝㝯୕㑻ࠊஂಖ᫂ࠊ
▼஭┤᫂ࠊすᓮὈᘯ
HDL ࢥࣞࢫࢸ࣮ࣟࣝளศ⏬࡜⬡㉁࣭࣏ࣜ⺮ⓑ௦ㅰࣉࣟࣇ࢓࢖ࣝࡢ㛵㐃ᛶ
➨ 43 ᅇ ᪥ᮏ⥲ྜ೺デᏛ఍ࠊᐩᒣ┴ᐩᒣᕷࠊ 2015.2.20
⳥ụ┿኱ࠊᒣ⏣༓✚ࠊᓊᮏ᠇᫂ࠊᱵ⏣⍠⨾Ꮚࠊ㭯㇂ᗣኴࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯ
⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡ࠊ⬡⫫⫢㝧ᛶ⋡ࡢኚ㑄
➨ 43 ᅇ ᪥ᮏ⥲ྜ೺デᏛ఍ࠊᐩᒣ┴ᐩᒣᕷࠊ 2015.2.20
⳥ụ┿኱ࠊᇼỤ⩏๎ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊすᓮὈᘯࠊᒣᓊ⏤
ᖾࠊຍ⸨┾୕ࠊ
㔠஭㝯඾
࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖࡢᛴᛶᮇ࡟࠾ࡅࡿ Fibroscan ⫢◳ᗘࡢព⩏
➨ 3㸲ᅇ ࢔ࣝࢥ࣮ࣝ་Ꮫ⏕≀Ꮫ◊✲఍ࠊ୕㔜ࠊ2015.1.24
⳥ụ┿኱ࠊ㧗ᯇ༓⧊ࠊ㕥ᮌᰤ㔛Ꮚࠊᱵ⏣⍠⨾Ꮚࠊሷ⃝ᏹ࿴ࠊ⳥ụ⨾✑ࠊ㧗ᶫṇᙪࠊ㏆⸨┿
⃈ࠊᒣ⏣༓✚ࠊ すᓮὈᘯ
ே㛫ࢻࢵࢡ࡛ࡢ⢾ᒀ⑓ᝈ⪅࡟࠾ࡅࡿ⫢ᶵ⬟␗ᖖ⋡࣭⬡⫫⫢㝧ᛶ⋡ࡢゎᯒ࡜ࠊFibroscan ࢹ
࣮ࢱࡢ᳨ウ
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
― 206 ―
ᒣ⏣༓✚ࠊ㏆⸨┿⃈ࠊ⳥ụ┿኱ࠊᓊᮏ᠇᫂ࠊ㛗஭㝧Ꮚࠊᰘ⏣೺㞝ࠊ௒すつࠊ➟ཱྀ㝯㔜ࠊ▼
஭┤᫂ࠊすᓮὈᘯ
೺ᖖே࡟࠾ࡅࡿ⫢ᶵ⬟࡜⾑୰࢔࣑ࣀ㓟⃰ᗘ࡜ࡢ㛵㐃
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
㏆⸨┿⃈ࠊᒣ⏣༓✚ࠊඖᮧஂಙࠊᓊᮏ᠇᫂ࠊすᓮὈᘯࠊ⳥ụ┿኱ࠊⓑ▼ග୍ࠊᮌᮧᏲḟࠊ
㇏⏣㞞ኵࠊ῝ᕝ㞞ྐ
ప࢚ࢿࣝࢠ࣮㣗࡜ SGLT-2 㜼ᐖ⸆ే⏝࡟ࡼࡾ 1 ࠿᭶࡛ 10 ਻ࡢῶ㔞࡟ᡂຌࡋࡓ 2 ᆺ⢾ᒀ⑓
ࡢ1౛
➨ 18 ᅇ᪥ᮏ⑓ែᰤ㣴Ꮫ఍ࠊி㒔ᗓி㒔ᕷࠊ2015.1.10
Ozawa H., Imanishi Y., Ito F., Watanabe Y., Kato T., Nameki H., Isobe K., Ogawa K.
PICO2 monitoring of transferred jejunum perfusion using an air tonometry technique
after hypopharyngeal cancer surgery. 3rd Congress of European ORL-HNS, Czech
Republic, Prague, June 2015
ᑠ⃝ᏹஅࠊ෠⏣ಇᶞࠊΏ㒊ెᘯࠊ㛵Ỉ┿⌮Ꮚࠊఀ⸨ᩥᒎࠊᡞ⏣ṇ༤ࠊᑠᕝ㑳㸬ෆど㙾ୗ㢌⵹
ᗏᡭ⾡࡟࠾ࡅࡿ modified nasal septal flap ࡢ᭷⏝ᛶ࡟ࡘ࠸࡚㸬➨ 25 ᅇ㢌㢕㒊እ⛉Ꮫ఍
2015 ᖺ 1 ᭶ ኱㜰
ᑠ⃝ᏹஅ ఀ⸨ᩥᒎ Ώ㒊ెᘯ 㛵Ỉ┿⌮Ꮚ ෠⏣ಇᶞ ᑠᕝ㑳㸬㢌㢕㒊⒴࡟࠾ࡅࡿྠᡤ
⛣᳜㌿⛣ࣔࢹࣝࡢ☜❧࡜ HIF㸯ǂ ࡢ㌿⛣࡬ࡢ㛵୚࡟ࡘ࠸࡚㸬➨ 39 㢌㢕㒊⒴Ꮫ఍ ⚄ᡞᕷ
2015 ᖺ 6 ᭶
ᑠ⃝ᏹஅࠊ෠⏣ಇᶞࠊΏ㒊ెᘯࠊ㛵Ỉ┿⌮Ꮚࠊఀ⸨ᩥᒎࠊ⊦⊁㞝୍ࠊᡞ⏣ṇ༤ࠊᑠᕝ㑳㸬ෆ
ど㙾ୗ㢌⵹ᗏᡭ⾡࡟࠾ࡅࡿ modified nasal septal flap ࡢ᭷⏝ᛶ࡟ࡘ࠸࡚㸬➨ 27 ᅇ᪥ᮏ㢌
⵹ᗏእ⛉Ꮫ఍ ྡྂᒇᕷ 2015 ᖺ 7 ᭶
⩚ ⏕ ᪼ ⸨ ஭ ṇ ே Expression of stem cell markers Oct3/4 and Nanog and its
implications for delayed neck metastasis in tongue carcinoma ➨ 74 ᅇ᪥ᮏ⒴Ꮫ఍Ꮫ⾡
⥲఍ ྡྂᒇ 2015.10.10
ⴠྜ༤ᏊࠊᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊ᱓ཎඞஅ.
⭝⭷ᛶ║▛ୗᆶ⑕࡟࠾ࡅࡿどᶵ⬟ኚ໬ࡢ᳨ウ㸬
➨30ᅇ៞᠕⩏ሿ኱Ꮫᙧᡂእ⛉ྠ㛛఍Ꮫ⾡㞟఍ࠊᮾிࠊ2015.1.24.
Ỉ㇂೺ேࠊᒸឡᏊࠊඵᮌ┤Ꮚࠊⴠྜ༤Ꮚ.
ᙜ㝔࡟࠾ࡅࡿ㛤㢌⾡ᚋឤᰁ⑕࡟ᑐࡍࡿ἞⒪ࡢ᳨ウ㸦࣏ࢫࢱ࣮㸧㸬
➨58ᅇ᪥ᮏᙧᡂእ⛉Ꮫ఍⥲఍࣭Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.4.9.
― 207 ―
ᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊⴠྜ༤Ꮚࠊ᱓ཎඞஅ.
⭝⭷ᛶ║▛ୗᆶ⑕࡟࠾ࡅࡿ⮬ぬ⑕≧ࡢ⾡ᚋኚ໬㸬
➨58ᅇ᪥ᮏᙧᡂእ⛉Ꮫ఍⥲఍࣭Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.4.9.
ⴠྜ༤ᏊࠊᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊ᱓ཎඞஅ.
║▛ୗᆶ⑕ᡭ⾡๓ᚋ࡟࠾ࡅࡿどᶵ⬟᳨ᰝ⤖ᯝࡢ᳨ウ㸬
➨58ᅇ᪥ᮏᙧᡂእ⛉Ꮫ఍⥲఍࣭Ꮫ⾡㞟఍ࠊி㒔ࠊ2015.4.9.
ⴠྜ༤Ꮚࠊᆏᮏዲ᫛ࠊỈ㇂೺ேࠊຍ⸨㐩ஓࠊ㈗ᚿ࿴⏕㸬
ࣛࢵࢺ㢌⵹㦵࡟࠾ࡅࡿ྾཰ᛶࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃࢱ࢖ࢺ/ࢥ࣮ࣛࢤࣥ」ྜయࡢ᭷⏝ᛶࡢ᳨ウ㸬
Annual Meeting for Society of Plastics and Regenerative Science(SPRS) ࠊරᗜࠊ20
15.6.27.
ⴠྜ༤ᏊࠊᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊᖹ⏣ᜨ㔛ࠊ᱓ཎඞஅ.
║▛ୗᆶ⑕⾡ᚋࡢどᶵ⬟ኚ໬ࡢ᳨ウ㸬
➨31ᅇ៞᠕⩏ሿ኱Ꮫᙧᡂእ⛉ྠ㛛఍Ꮫ⾡㞟఍ࠊᮾிࠊ2015.7.11.
ᖹ⏣ᜨ㔛ࠊᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊⴠྜ༤Ꮚ.
ᙜ⛉࡟࠾ࡅࡿ⮖㒊⭘⒆⑕౛ࡢ᳨ウ㸬
➨31ᅇ៞᠕⩏ሿ኱Ꮫᙧᡂእ⛉ྠ㛛఍Ꮫ⾡㞟఍ࠊᮾிࠊ2015.7.11.
Hiroko Ochiai, Takehito Mizutani, Naoko Yagi, Aiko Oka, Eri Hirata,
Yoshiaki Kuroshima.
Management of cranial bone defect cases caused by infection.
The 16th congress of international society of craniofacial surgery (ISCFS),2015. C
hiba Japan, 2015.9.18.
ᆏᮏዲ᫛ࠊⴠྜ༤Ꮚࠊ㈗ᚿ࿴⏕㸬
⮬ᐙ㦵⨨᥮ᆺ྾཰ᛶேᕤ㦵ࡢຠ⋡ⓗ࡞㦵෌⏕࡟ࡴࡅ࡚㸬
➨24ᅇ᪥ᮏᙧᡂእ⛉Ꮫ఍ᇶ♏Ꮫ⾡㞟఍ࠊᒾᡭࠊ2015.10.8.
ⴠྜ༤ᏊࠊᒸឡᏊࠊỈ㇂೺ேࠊඵᮌ┤Ꮚࠊᖹ⏣ᜨ㔛ࠊ᱓ཎඞஅ.
║▛ୗᆶ⑕ᡭ⾡ᚋ࡟࠾ࡅࡿどᶵ⬟ኚ໬ࡢ᳨ウ㸬
➨33ᅇ᪥ᮏ㢌⵹㢡㢦㠃እ⛉Ꮫ఍Ꮫ⾡㞟఍ࠊරᗜࠊ2015.11.12.
Ỉ㇂೺ேࠊᒸឡᏊࠊඵᮌ┤Ꮚࠊⴠྜ༤Ꮚ.
㛤㢌⾡ᚋឤᰁ⑕࡟኱⭣➽⭷⛣᳜ࢆ᪋⾜ࡋࡓ⑕౛ࡢ᳨ウ㸬
➨28ᅇ៞᠕⩏ሿ኱Ꮫᙧᡂእ⛉ྠ㛛఍Ꮫ⾡㞟఍ࠊᮾிࠊ2014.1.25.
― 208 ―
[ ㅮ₇ ]
⸨஭ṇே
Masato Fujii Current and future role of chemoradiation for oropharyhgeal cancer based
on HPV status 4th Congress of Asian Society of Head and Neck Oncology ⚄ ᡞ
2015.6.5
⸨஭ṇே
Masato Fujii Multimodality treatment for oropharyngeal cancer based on HPV status
13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery ᮾ ி
2015.12.3-4
⸨஭ṇே
㢌㢕㒊ࡀࢇ࡟ᑐࡍࡿ㞟Ꮫⓗ἞⒪ࡢ㐍Ṍ㸫໬Ꮫᨺᑕ⥺⒪ἲࢆ୰ᚰ࡟㸫➨ 25 ᅇ᪥ᮏ㢌㢕㒊እ
⛉Ꮫ఍ ኱㜰 2015.1.29
⸨஭ṇே
㢌㢕㒊ࡀࢇ ࢔࢟ࣂ ࢟ࣕࣥࢧ࣮ࣇ࢛࣮࣒ࣛ㸰㸮㸯㸳 ᮾி 2015.8.8
⸨஭ṇே
㢌㢕㒊⒴ࡢ㞟Ꮫⓗ἞⒪࡟࠾ࡅࡿศᏊᶆⓗ⸆ࡢᙺ๭ ➨ 5 ᅇ༡኱㜰㢌㢕㒊⭘⒆ࣇ࢛࣮࣒ࣛ
኱㜰 2015.10.3
⸨஭ṇே
㢌㢕㒊⒴἞⒪ࡢ᭱๓⥺-⸆≀἞⒪ࡢ᪂ᒎ㛤㸫 ᮾி㒔⪥㰯ဗႃ⛉་఍Ꮫ⾡ㅮ₇఍ ᮾி
2016.1.30
༡ಟྖ㑻
ᮾி་⒪ࢭࣥࢱ࣮ࡢ㞴⫈࣭⪥㬆デ⒪ 㹼⫈⬻ࢺ࣮ࣞࢽࣥࢢ࡛㐺ྜࡉࡏࡿ⿵⫈ჾ㹼
┠㯮༊⪥㰯ဗႃ⛉㒊఍Ꮫ⾡ㅮ₇఍ࠊᮾிࠊ2015.12.3
༡ಟྖ㑻
⪥㰯ဗႃ⛉㸸⪥⛉㰯⛉㡿ᇦ⑌ᝈࡢ⑓ែ࡜἞⒪ἲ
ᮾி་⒪ಖ೺኱Ꮫࠊᮾிࠊ2016.1.6, 2016.1.12
༡ಟྖ㑻
⪥㰯ဗႃ⛉㸸ဗႃ㢌㡿ᇦ⑌ᝈࡢ⑓ែ࡜἞⒪ἲ
ᮾி་⒪ಖ೺኱Ꮫࠊᮾிࠊ2016.1.18, 2016.1.19
༡ಟྖ㑻
⪥㰯ဗႃ⛉㸸㢁㒊㡿ᇦ⑌ᝈࡢ⑓ែ࡜἞⒪ἲ
ᮾி་⒪ಖ೺኱Ꮫࠊᮾிࠊ2016.1.20, 2016.1.25
― 209 ―
ᒣ⃝୍ᶞ
㑇ఏᛶஙࡀࢇ࣭༸ᕢࡀࢇ⑕ೃ⩌㸦HBOC㸧࡟ࡘ࠸࡚ࡢྲྀࡾ⤌ࡳ
ᅜ❧⑓㝔ᶵᵓ ᖹᡂ 27 ᖺᗘ ࢳ࣮࣒་⒪᥎㐍ࡢࡓࡵࡢ◊ಟ㸰㸦ࡀࢇ㸧 ᮾி 2015 ᖺ 10
᭶ 23 ᪥
ᯇỌ㐩㞝
㞴⫈㑇ఏᏊ᳨ᰝࡢṇࡋ࠸⌮ゎ࡜ά⏝
➨ 129 ᅇ㞴⫈ゝㄒ㞀ᐖ◊✲఍ࠊ⚄ዉᕝ┴ࠊ2015.2.21.
ᯇỌ㐩㞝
᭱ඛ➃ࢩ࣮ࢡ࢚ࣥࢧ࣮ࢆ⏝࠸ࡓ㑇ఏᏊ᳨ᰝ࡛ᗈࡀࡿ㞴⫈デ⒪
➨ 10 ᅇᕷẸබ㛤ㅮᗙ㸦⫈ぬ㞀ᐖࢩ࣮ࣜࢬ㸧ࠊᮾி㒔ࠊ2015.3.27.
ᯇỌ㐩㞝
ᑠඣ㞴⫈ࡢ⑓ែ࡜デ⒪
➨ 5 ᅇ NICU ࣇ࢛࣮ࣟ࢔ࢵࣉ᳨ウ఍ࠊ୕㔜┴ࠊ2015.11.26.
ᯇỌ㐩㞝
㞴⫈ࡢ㑇ఏᏊデ⒪࡜඲㌟⑌ᝈ
➨ 15 ᅇୡ⏣㇂༊་ᖌ఍་Ꮫ఍ࠊᮾி㒔ࠊ2015.12.5.
ⴠྜ༤Ꮚ
〟⒔ࡢヰ
඲ᅜ⬨㧊ᦆയ⪅㐃ྜ఍≉ูㅮ₇ࠊᮾிࠊ2015.5.24.
ⴠྜ༤Ꮚ
INFOM࡟ࡘ࠸࡚
ᅜ㝿⮬↛࣭᳃ᯘ་Ꮫ఍Ꮫ⾡ㅮ⩦఍ㅮᖌࠊ㛗㔝ࠊ2015.8.22.
[◊ಟ࣭ㅮᖌ]
ᯇỌ㐩㞝
㸦ㅮᖌ㸧ᖹᡂ 27 ᖺᗘ⫈ຊ ᐃᢏ⾡ㅮ⩦఍
୍⯡ ྜྠᐇ⩦㸦II㸧ㄒ㡢࣭࢖ࣥࣆ࣮ࢲࣥࢫࠊᮾி㒔ࠊ2015.2.11.
[ ≉チ ]
≉チฟ㢪㸸Ⓨ᫂ࡢྡ⛠ࠕෆ⪥ᛶ㞴⫈἞⒪⸆ࠖ≉㢪 2015-007849 ฟ㢪᪥ 2015 ᖺ 1 ᭶ 19 ᪥
Ⓨ᫂⪅㸸⣽㇂ㄔࠊ⸨ᒸṇேࠊᒸ㔝ᰤஅࠊᑠᕝ㑳ࠊᯇỌ㐩㞝 ᅜෆ
― 210 ―
[ ࡑࡢ௚ ]
⸨஭ṇே (ᗙ㛗)➨ 17 ⩌ ໬Ꮫᨺᑕ⥺⒪ἲ㸯➨ 26 ᅇ᪥ᮏ㢌㢕㒊እ⛉Ꮫ఍⥲఍ ྡྂᒇ
2016.1.28
⸨஭ṇே (ྖ఍) ᝈ⪅ࡢኌ࠿ࡽཱྀ⭍ࡀࢇࡢ἞⒪࡜ࢧ࣏࣮ࢺ࡟ࡘ࠸࡚⪃࠼ࡿ ➨ 34 ᅇ᪥ᮏ
ཱྀ⭍⭘⒆Ꮫ఍ ᶼ὾ 2016.1.22
⸨஭ṇே (ᗙ㛗)ࢩ࣏ࣥࢪ࣒࢘ 19 㢌㢕㒊 ௒ࠊヰ㢟ࡢ⑌ᝈ㸸HPV 㝧ᛶࡢ୰ဗ㢌⒴ ➨ 35
ᅇ ᪥ᮏ⏬ീ་Ꮫ఍ ᮾி 2016.2.26
⸨஭ṇே (ྖ఍) 㐍⾜㢌㢕㒊⒴࡟ᑐࡍࡿ㞟Ꮫⓗ἞⒪㸫࢚ࣅࢹࣥࢫ࡜ᐇ⮫ᗋ ➨ 21 ᅇ 㢌
㢕㒊⒴໬Ꮫ⒪ἲ◊✲఍ ᮾி 2016.2.26
Masato Fujii (ᗙ㛗)Symposium 5 Personalized Chemoradiotherapy 4th Congress of
Asian Society of Head and Neck Oncology ⚄ᡞ 2015.6.5
⸨஭ṇே (ྖ఍)ࣛࣥࢳࣙࣥࢭ࣑ࢼ࣮㸰 ⏥≧⭢㞴἞ࡀࢇ࡬ࡢᣮᡓ ➨ 116 ᅇ ᪥ᮏ⪥㰯
ဗႃ⛉Ꮫ఍ ⥲఍ ᮾி 2016.5.21
⸨஭ṇே (ྖ఍)㢌㢕㒊ࡀࢇ࡟ᑐࡍࡿ໬Ꮫ⒪ἲࡢ᪂ᒎ㛤 ➨ 67 ᅇ ᪥ᮏẼ⟶㣗㐨⛉Ꮫ఍⥲
఍ ⚟ᓥ 2015.11.19
ゅ⏣㐩ᙪࠊ ᐑ෤ᶞࠊᯇỌ㐩㞝ࠊົྎⱥᶞ
㸦ࣉࣞࢫ࣮ࣜࣜࢫ㸧࣐࢘ࢫࡢ㞴⫈㐍⾜ᢚไ࡟㛵୚ࡍࡿ㑇ఏᏊ᝟ሗࢆ⥙⨶ⓗ࡟཰㞟㸫㞴⫈㐍
⾜࡟㛵ࢃࡿ㑇ఏᏊ᥈⣴ࡢᡭࡀ࠿ࡾ࡜࡞ࡿࢹ࣮ࢱࢆබ㛤㸫
⌮໬Ꮫ◊✲ᡤࠊ2015.7.15.
ᯇỌ㐩㞝
Ꮚ࡝ࡶࡢ㞴⫈㸦㸱㸧㑇ఏᏊデ᩿࡛ᡭ⾡Ỵ᩿
ㄞ኎᪂⪺ᮅห ་⒪ࣝࢿࢧࣥࢫ No.6114 ࠊ2015.7.29.
ゅ⏣㐩ᙪࠊ ᐑ෤ᶞࠊᯇỌ㐩㞝ࠊົྎⱥᶞ
㞴⫈㐍⾜ᢚไ࡟㛵ࢃࡿ㑇ఏᏊ᝟ሗ ࣐࢘ࢫ࡛⥙⨶ⓗ࡟཰㞟ࠊࢹ࣮ࢱࢆබ㛤
⛉Ꮫ᪂⪺ ➨ 3546 ྕࠊ2015.7.31.
ゅ⏣㐩ᙪࠊ ᐑ෤ᶞࠊᯇỌ㐩㞝ࠊົྎⱥᶞ
㞴⫈㐍⾜㛵୚ࡢ㑇ఏᏊ᝟ሗ ⥙⨶ⓗ࡟཰㞟ࡋࢹ࣮ࢱබ㛤
⸆஦᪥ሗ ᮅห 3 㠃ࠊ2015.7.31.
― 211 ―
ᯇỌ㐩㞝
㸦ྖ఍㸧➨ 10 ᅇឤぬჾࢩ࣏ࣥࢪ࣒࢘㸦ᮾி་⒪ࢭࣥࢱ࣮㸧㹼ᖿ⣽⬊࣭iPS ⣽⬊ࢆ⏝࠸ࡓឤ
ぬჾ◊✲ࡢ᭱๓⥺㹼ࠊᮾி㒔ࠊ2015.3.6.
ᯇỌ㐩㞝
㸦ྖ఍㸧᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍ᮾி㒔ᆅ᪉㒊఍౛఍ ➨ 206 ᅇᏛ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.3.14.
ᯇỌ㐩㞝
㸦ᗙ㛗㸧୍⯡ㅮ₇ࠕ㞴⫈㑇ఏᏊϨࠖ
➨ 116 ᅇ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾி㒔ࠊ2015.5.20-23.
ᯇỌ㐩㞝
㸦ᗙ㛗㸧Free Papers 23: Auditory Neuropathy, Cochlear Nerve Deficiency
30th Politzer Society Meetingࠊ᪂₲┴ࠊ2015.6.30-7.3.
ᯇỌ㐩㞝
㸦ᗙ㛗㸧୍⯡ㅮ₇㸦ཱྀ₇㸧 ➨ 61 ⩌ࠕ㑇ఏᏊ 2ࠖ
➨ 25 ᅇ᪥ᮏ⪥⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍
㛗ᓮ┴ࠊ2015.10.7-10.
ᯇỌ㐩㞝
㸦ᗙ㛗㸧➨ 23 ⩌㸸⫈ぬ㞀ᐖ 5
➨ 60 ᅇ᪥ᮏ⫈ぬ་Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍
ᮾி㒔ࠊ2015.10.21-23.
ᾆᒸಇኵ
ࠗୖ㒊ᾘ໬⟶⑌ᝈデ⒪࡬ࡢ᪂ࡓ࡞ࡿ࢔ࣉ࣮ࣟࢳ࠘₇⪅㸸៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊 ෆ⛉Ꮫ㸦ᾘ໬
ჾ㸧෸ᩍᤵ 㕥ᮌ ⚽࿴ ඛ⏕㸬
ᾘ໬ჾ⑌ᝈࢆ⪃࠼ࡿ఍㸬ᮾி㒔῰㇂༊, 2015.4
ᾆᒸಇኵ
୍⯡ཱྀ₇㸦SSA/P㸧㸬
➨ 89 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍⥲఍㸬ឡ▱┴ྡྂᒇᕷ, 2015.5
ᾆᒸಇኵ
୍⯡ཱྀ₇㸦⫶ ESD-4㸧㸬
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍㸬ᮾி㒔᪂ᐟ༊, 2015.6
― 212 ―
ᾆᒸಇኵ㸬
⑕౛᳨ウ࣭ㅮ₇㸬➨୍ᅇ࣭ᮾࡀୣᾘ໬ჾࢿࢵࢺ࣮࣡ࢡ㸬
ᮾி㒔┠㯮༊, 2015.8
ᾆᒸಇኵ
ࠗ኱⭠ෆど㙾ࢺ࣮ࣞࢽࣥࢢἲ - ⌧≧࡜ㄢ㢟 -࠘₇⪅㸸㡰ኳᇽ኱Ꮫ་Ꮫ㒊 ෸ᩍᤵ ᆏᮏ ┤
ே ඛ⏕㸬COLONetwork 2015㸬ᮾி㒔࣭༓௦⏣༊, 2015.8
ᾆᒸಇኵ
⑕౛᳨ウ࣭ㅮ₇㸬
➨ 11 ᅇ Gut Challenge Meeting㸬ᮾி㒔Ụᮾ༊, 2015.8
ᾆᒸಇኵ
⑕౛᳨ウࢭࢵࢩࣙࣥࢥ࣓ࣥࢸ࣮ࢱ࣮㸬
➨ 12 ᅇ᪥ᮏᾘ໬⟶Ꮫ఍Ꮫ⾡㞟఍㸬ᮾி㒔᪂ᐟ༊, 2015.2
ᾆᒸಇኵ
⑕౛᳨ウࢭࢵࢩࣙࣥㄞᙳ⪅㸬
➨ 100 ᅇ᪥ᮏᾘ໬ჾෆど㙾Ꮫ఍㛵ᮾᆅ᪉఍㸬ᮾி㒔᪂ᐟ༊, 2015.6
ᾆᒸಇኵ
㌟㏆࡞⑓ẼࠊẼ࡟࡞ࡿ⑕≧ 㹼࠸ࡲ࡝ࡁࡣࡇ࠺┤ࡍ㸟㹼 ኱⭠࣏࣮ࣜࣉ㸦๓⦅㸧
ᮾிࢫ࣏࣮ࢶ 2015. 10.20
ᾆᒸಇኵ
㌟㏆࡞⑓ẼࠊẼ࡟࡞ࡿ⑕≧ 㹼࠸ࡲ࡝ࡁࡣࡇ࠺┤ࡍ㸟㹼 ኱⭠࣏࣮ࣜࣉ㸦ᚋ⦅㸧
ᮾிࢫ࣏࣮ࢶ 2015. 10.27
Ỉ㊊㑥㞝
㞴⫈࡟ࡼࡿ࠺ࡘࢆண㜵㸸ᢚ࠺ࡘࠊㄆ▱㞀ᐖࢆᨵၿ:᪩ࡵ࡟⿵⫈ჾࢆά⏝
ᒱ㜧᪂⪺௚ᆅ᪉⣬ ᖹᡂ 27 ᖺ 1 ᭶ 24 ᪥
― 213 ―
㻌
㻌
㻌
㻌
ேᕤ⮚ჾ䞉ᶵჾ㛤Ⓨ◊✲㒊㻌
㻌
ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊
㹙 ㄽᩥ 㹛
Kobayashi R, Tsunoda K, Ueha R, Fujimaki Y, Saijo H, Itoh K, Yamasoba T.
Effect of a nasal clip on inhaling a sufficient cortico steroid powder dose.
Ann Allergy Asthma Immunol. 2015Dec;115(6):525-6.
impact factor 2.60
Tsunoda K, Fujimaki Y, Nito T, Yamasoba T, Tayama N, Makiyama K, Murofushi T,
Tsunoda A, Ohshima K, Nishiyama K, Kano S, Niimi S.
Patients' perceptions of vocal problems: results from a survey in the Tokyo area.
Acta Otolaryngol. 135(6):532-5, 2015.6
impact factor 1.09
Kikuta S, Sakamoto T, Nagayama S, Kanaya K, Kinoshita M, Kondo K, Tsunoda K,
Mori K, Yamasoba T.
Sensory deprivation disrupts homeostatic regeneration ofnewly generated olfactory
sensory neurons after injury in adult mice.
J Neurosci. 11;35(6):2657-73, 2015.2
impact factor 6.34
Nomura T, Ushio M, Kondo K, Yamasoba T
Effects of nasal septum perforation repair surgery on three-dimensional airflow: an
evaluation using computational fluid dynamics.
Eur Arch Otorhinolaryngol. 272(11)㸸3327-33㸪2015.11
impact factor 1.55
Nomura T, Kobayashi T, Shingaki S, Saito C.
A case of chondrosarcoma arising in the temporomandibular joint.
Case Rep Otolaryngol.2015:832532. 2015.1
impact factor 0
Nomura T, Shingaki S, Kobayashi T , Suzuki I, Saito C
Multi-factorial func- tional analysis of the patients with reconstructtion for oral
carcinoma.
Open Journal of Stomatology. 5:63-71, 2015
impact factor 0
― 215 ―
Sakurai Y, Itoh K, Sai K, Lee S, Abe S, Terao Y, Mannen T
Impaired laryngeal voice production in a patient with foreign accent syndrome
Neurocase 21㸸289-98㸪2015.4
impact factor 1.336
Atsushi ItoࠊHiroyuki HatanoࠊMasahiro FujiiࠊMie SatoࠊYu Watanabeࠊ
Yuko HiramatsuࠊFumihiro Sato and Akira Sasakiࠊ
"Performance Evaluation of Ad Hoc Network Protocol Implemented in Server Side
Java Script"ࠊ
International Workshop on Networking, Computing, Systems, and Software
(NCSS) 2015 (2015.12)
impact factor
0
㹙 ⥲ㄝ 㹛
ゅ⏣᫭୍
ࠕ࿡ぬ㞀ᐖࠖ
MR ࢸ࢟ࢫࢺϩ ⑌⑓࡜἞⒪ 2012 ⮫ᗋ 2015 ᖺᨵゞ㸬MR ㄆᐃࢭࣥࢱ࣮,༡ᒣᇽ㸬
2015:180-181
ゅ⏣᫭୍
㞟ႃ㢌␗ᖖឤࡢ␲ၥ࡟⟅࠼ࡿ ࡝ࡢࡼ࠺࡞඲㌟ⓗ⑌ᝈࡀ㛵ಀࡍࡿࡢ࡛ࡋࡻ࠺࠿
JOHNS 31ᕳ1ྕ㸸81-83㸬2015.1
ゅ⏣᫭୍
೺ᗣ㛗ᑑ♫఍࡬ࡢ⪥㰯ဗႃ⛉ࡔ࠿ࡽ࡛ࡁࡿຍ㱋࡟ࡼࡿᄟୗⓎኌ㞀ᐖࡢண㜵
ᮾி㒔⪥㰯ဗႃ⛉་఍ሗ 146㸸27-33, 2015.2
ゅ⏣᫭୍
ႍ㬆ࡢ⏕ࡌࡿ࣓࢝ࢽࢬ࣒ࢆᩍ࠼࡚ୗࡉ࠸
ᚰᅉᛶኻኌࡣ࡝࠺ࡋ࡚࠾ࡁࡲࡍ࠿㸽
௒ࡉࡽ⪺ࡅ࡞࠸㸟 ᑠඣࡢࡳࡳ࣭ࡣ࡞࣭ࡢ࡝デ⒪ Q㸤A ϩᕳ, 133ࠊ244ࠊᰴᘧ఍♫඲᪥
ᮏ⑓㝔ฟ∧఍ࠊ2015.4
㹙 ⴭ᭩ 㹛
ゅ⏣᫭୍
ࠕ௒᪥࠿ࡽ࡛ࡁࡿኌᖏࢺ࣮ࣞࢽࣥࢢ ೺ᗣ㛗ᑑࡣ఍ヰ࠿ࡽࠖ
࣓ࢹ࢕࢝ࣝࢺࣜࣅ࣮ࣗࣥ♫ 2015.4.3 ฟ∧
― 216 ―
㹙 Ꮫ఍Ⓨ⾲ 㹛
ゅ⏣᫭୍
⯉ᅽᏊɆయᆺཱྀ⭍ဗ㢌ෆど㙾㸦ࣉࣟࢪ࢙ࢡࢺྡ㸸NTOP2013㸧
ࡇࡢ୍ᖺ㛫ࡢ㐍Ṍ≧ἣ࡟ࡘ࠸࡚
➨ 116 ᅇ ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ᮾி ᅜ㝿ࣇ࢛࣮࣒ࣛ 2015.5.23
ゅ⏣᫭୍
Ⓨኌ㞀ᐖ࡟ᑐࡍࡿ✚ᴟⓗ௓ධ
➨ 15 ᅇ ᪥ᮏᢠຍ㱋་Ꮫ఍⥲఍ࠊ⚟ᒸᅜ㝿఍㆟ሙ 2015.5.29-31
ゅ⏣᫭୍
་⒪ࡢ㉁ྥୖ࡜ࠊᏳ඲ᛶྥୖࡢࡓࡵࡢࠊཱྀ⭍ဗ㢌㙾ࡢ㛤Ⓨ࡜ࠕ⯉ᅽᏊ୍యᆺཱྀ⭍ဗ㢌ෆ
ど㙾ࠖ㸦ࣉࣟࢪ࢙ࢡࢺྡ㸸NTOP2013㸧࡟ࡘ࠸࡚
➨ 69 ᅇ ᅜ❧⑓㝔⥲ྜ་Ꮫ఍ ࡉࡗࡱࢁⱁ⾡ᩥ໬ࡢ㤋 2015.10.3
ゅ⏣᫭୍ࠊᑠᯘ⌮㤶ࠊ▼஭㇏ኴࠊ୕⃝㐓ே ࠊ㯮⏣ᾈஅࠊୖ⩚⍠⨾ࠊ⸨ᕳⴥᏊࠊ஧⸨㝯᫓ࠊ
ᒣᒽ㐩ஓ
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊࡑࡢ᭷ຠᛶࡢ᳨ド
㸫ၨⵚ࠿ࡽၨⓎ࡬㸫
➨ 60 ᅇ᪥ᮏ㡢ኌゝㄒ་Ꮫ఍ ྡྂᒇ࣭ឡ▱┴⏘ᴗປാࢭࣥࢱ࣮ 2015.10.15-16
ゅ⏣᫭୍
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊࡑࡢ᭷ຠᛶࡢ᳨ド
➨ 67 ᅇ ᪥ᮏẼ⟶㣗㐨⛉Ꮫ఍࡞ࡽࡧ࡟Ꮫ⾡ㅮ₇఍
ࢨ࣭ࢭࣞࢡࢺࣥ⚟ᓥ࣭࣍ࢸࣝ⚟ᓥࢢ࣮ࣜࣥࣃࣞࢫ 2015.11.19-20
ゅ⏣᫭୍
ᅜ❧⑓㝔ᶵᵓ࡟࠾ࡅࡿࠊኌࡢ⾨⏕ᩍ⫱࡟ࡼࡿಖᏑ⒪ἲࡢ᭷ຠᛶࡢ᳨ド
ᖹᡂ 27 ᖺᗘ ⪥㰯ဗႃ⛉ኟᮇ⮫ᗋࣇ࢛࣮࣒ࣛ ᮾி኱Ꮫᒣୖ఍㤋 2015.7.11
㔝ᮧົࠊᓊᮏࡵࡄࡳࠊᒾᇛᘯᑦࠊ㉺ᬛ⠜ࠊᓊᮏㄔྖ
ᨺᑕᛶࣚ࢘⣲ෆ⏝⒪ἲࢆ᳨ウࡍࡿ࡟࠶ࡓࡗ࡚ዷᏎᛶ Ꮡ࡬ࡢ㓄៖ࢆせࡋࡓ⏥≧⭢⒴ࡢ
1౛
Maxillary Swing Approach for Removal of the Palatal Carcinoma
4th Congress of ASHNO and 39th annual meeting of JSHNC ኱㜰 2015.6.4
㔝ᮧົࠊ ኱ᮌ 㞞ᩥࠊ኱⏿ ᩔࠊᓊᮏ ㄔྖ
デ᩿࡜἞⒪ࡢࢥࢶ 㢡ୗ⭢ᡭ⾡ Ᏻ඲࣭☜ᐇ࡞ᡭᢏ ゎ๗࡟ᇶ࡙ࡃ㢡ୗ⭢ᡭ⾡
➨ 28 ᅇ᪥ᮏཱྀ⭍࣭ဗ㢌⛉Ꮫ఍⥲఍ࠊ኱㜰ࠊ2015.9.10-11
― 217 ―
㔝ᮧົࠊ ᓊᮏࡵࡄࡳࠊᒾᇛᘯᑦࠊ ㉺ᬛ⠜ࠊᓊᮏㄔྖ
㢁⚄⤒ྀࢆ⏝࠸ࡓ㢦㠃⚄⤒෌ᘓࡢ 2 ౛
➨ 38 ᅇ᪥ᮏ㢦㠃⚄⤒Ꮫ఍⥲఍ࠊᮾிࠊ2015.6.11-12
㔝ᮧົࠊ㧘ᔱṇ฼ࠊ኱ᮌ㞞ᩥࠊ⳥ᆅⱱ
ᝏᛶ⭘⒆ࡀ␲ࢃࢀࡓ㢕㒊㯤Ⰽ⫗ⱆ⭘ᛶ⅖⑕ࡢ୍౛
෤ᮇ⮫ᗋࣇ࢛࣮࣒ࣛ㸦㕲㛛グᛕㅮᇽ㸧ࠊᮾிࠊ2015.12.12
ఀ⸨᠇἞, ᯈᇉᩥᙪ, ୹⩚┿୍
஘ᩘ⏕ᡂ㡢ኌ࣭ືస⣔ิࡢ≉ᚩ࡜࣮࣡࢟ࣥࢢ࣓ࣔࣜ࡜ࡢ㛵㐃
2015 ᖺ㟁Ꮚ᝟ሗ㏻ಙᏛ఍⥲ྜ኱఍, ⲡὠᕷ, 2015.3.12
ᑠ㔝ဴ἞, ఀ⸨᠇἞, 㛵ᮏⲮኴ㑻, ゅ⏣᫭୍
ගࢺ࣏ࢢࣛࣇ࢕ࡢゝㄒ㛵㐃⬻άືゎᯒཬࡧ BMI ࡬ࡢᛂ⏝
2015 ᖺ㟁Ꮚ᝟ሗ㏻ಙᏛ఍⥲ྜ኱఍, ⲡὠᕷ, 2015.3.12
ᯈᇉᩥᙪ, ఀ⸨᠇἞, ᇼ⋞
࣮࣡࢟ࣥࢢ࣓ࣔࣜ࡜๰㐀ᛶࡢ᥋Ⅼ—஘ᩘ⏕ᡂㄢ㢟ࡢศᯒ࠿ࡽ—
➨ 8 ᅇ 21 ୡ⣖⛉Ꮫ࡜ே㛫ࢩ࣏ࣥࢪ࣒࢘, ᮾி, 2015.3.6
ᑠ㔝ဴ἞, ఀ⸨᠇἞, 㛵ᮏⲮኴ㑻, ゅ⏣᫭୍, ᭷㈡ṇᾈ
ගࢺ࣏ࢢࣛࣇ࢕ࢆ⏝࠸ࡓゝㄒ㛵㐃ࡢ⬻άືゎᯒ
➨ 8 ᅇ 21 ୡ⣖⛉Ꮫ࡜ே㛫ࢩ࣏ࣥࢪ࣒࢘, ᮾி, 2015.3.6
ྜྷ⸨⿱ెᏊ, ‫‮‬ᮏ┿ே, ⊁㔝❶ኴ㑻, ఀ⸨᠇἞, ᒣᒽ㐩ஓ
㡢ീࡢᖜࡢ⫈ᛶㄏⓎ⬻☢ሙᛂ⟅࡬ࡢ཯ᫎ
➨ 20 ᅇㄆ▱⚄⤒⛉Ꮫ఍Ꮫ⾡㞟఍, ᮾி, 2015.8.8
ᮃ᭶᫂ே, 㡲⸨㊰Ꮚ, ᱒㔝⾨஧, ఀ⸨᠇἞
᝟ືㄢ㢟ฎ⌮࡟࠾ࡅࡿ㐠ືࡢ♫఍ㄆ▱࣭ゝㄒ⬟ຊ࡟୚࠼ࡿᙳ㡪
➨ 70 ᅇ᪥ᮏయຊ་Ꮫ఍኱఍, ࿴ḷᒣ, 2015.9.18
⸨ᕳⴥᏊࠊゅ⏣᫭୍ࠊ௚
ᅜ❧⑓㝔ᶵᵓࠕ㡢ኌ⮬ᕫカ⦎ἲ࡟ࡼࡿ⫵⅖ࡢண㜵ຠᯝࡢ᳨ドࠖ◊✲⌜
㡢ኌ஦ᨾカ⦎ἲ࡟ࡼࡿ⫵⅖ࡢண㜵ຠᯝࡢ᳨ド㸸Randomuzed Control Trial
➨ 116 ᅇ ᪥ᮏ⪥㰯ဗႃ⛉Ꮫ఍⥲఍࣭Ꮫ⾡ㅮ₇఍ࠊᮾிࠊ2015.5.21
― 218 ―
⸨ᕳⴥᏊ
㢦㠃⚄⤒ษ᩿ᚋ࡟࠾ࡅࡿ G-CSF ࡟ࡼࡿ⚄⤒෌⏕ಁ㐍ຠᯝࡢ᳨ウ
➨ 38 ᅇ᪥ᮏ㢦㠃⚄⤒Ꮫ఍ࠊᮾிࠊ2015.6.11
Yoko Fujimaki, Kenji Kondo, Shotaro Karino, Yayoi Kikkawa,
Yu Matsumoto, Chisato Fujimoto, Shu Kikuta, Hironobu Nishijima,
Kazuo Yasuhara, Teru Kamogashira, Akinobu Kakigi, Koichi Tsunoda,
Tatsuya Yamasoba
The effect of G-CSF for promoting regeneration of severed facial nerves in rats
13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, Tokyo,
2015.12.4
㹙 ≉ูㅮ₇ 㹛
ゅ⏣᫭୍
Laryngeal Problems in Advanced Age and Cost-Effective Solutions
➨ 13 ᅇ ᪥ᮏྎ‴⪥㰯ဗႃ⛉࣭㢌㢕㒊እ⛉Ꮫ఍㆟ ୍ࢶᶫ࣮࣍ࣝ㸦Ꮫ⾡⥲ྜࢭࣥࢱ࣮㸧
2015.12.3-4
ゅ⏣᫭୍
⪥㰯ဗႃ⛉ࡔ࠿ࡽ࡛ࡁࡿ་⒪㠃࠿ࡽࡳࡓ೺ᗣ㛗ᑑ࡬ࡢྲྀࡾ⤌ࡳ
᪥⪥㰯ᰣᮌᆅ᪉㒊఍ ➨ 119 ᅇᏛ⾡ㅮ₇఍ࠊ㊊฼ᕷࠊ2015.12.13
㹙 ࡑࡢ௚ 㹛
ࢸࣞࣅฟ₇
㹌㹆㹉 㹃ࢸࣞࠕࢳࣙ࢖ࢫ@⑓Ẽ࡟࡞ࡗࡓ࡜ࡁࠖ
ࢸ࣮࣐ࠕẼ࡟࡞ࡿኌࡢ࠿ࡍࢀࠖ 2015.10.24 ᨺ㏦᪥
㞧ㄅᥖ㍕
ゅ⏣᫭୍
NHK ࡓࡵࡋ࡚࢞ࢵࢸࣥ ࢫ࣑ࢭ࢖∧ ゅ⏣᫭୍┘ಟࠕኌࡢ࠿ࡍࢀࢆᨵၿࡍࡿ࣡ࢨࠖ
୺፬࡜⏕ά♫/㟷୹♫ 2015.5 ᭶ྕ
ゅ⏣᫭୍
ࡅࢇࡱࡔࡼࡾ ࡅࢇࡇ࠺ Q&Aࠕኌᖏⴎ⦰࡟ࡼࡿኌࡢ࠿ࡍࢀࠖ2015 ᖺ⛅ྕ
― 219 ―
㻌
㻌
㻌
㻌
ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
㻌
ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊
࠙ㄽᩥࠚ
Nakanishi A, Ueno S, Kawano K, Ito Y, Kominami T, Yasuda S, Kondo M, Tsunoda K,
Iwata T, Terasaki H.
Pathologic Changes of Cone Photoreceptors in Eyes With
Occult Macular Dystrophy.
Invest Ophthalmol Vis Sci. 2015;56:7243-9
Iejima D, Nakayama M, Iwata T.
HTRA1 Overexpression Induces the Exudative Form of Age-Related Macular
Degeneration. Age-Related Macular Degeneration: Prevalence, Risk Factors and Clinical
Management. (Editor: Meanie Carter) Nova Science Publishers, 2015
Katagiri S, Hayashi T, Ohkuma Y, Sekiryu T, Takeuchi T, Gekka T, Kondo M, Iwata T,
Tsuneoka H.
Mutation analysis of BEST1 in Japanese patients with Best's vitelliform macular
dystrophy. Br J Ophthalmol. 2015;99:1577-82
Katagiri S, Hayashi T, Yoshitake K, Sergeev Y, Akahori M, Furuno M, Nishino J, Ikeo K,
Tsunoda K, Tsuneoka H, Iwata T.
Congenital Achromatopsia and Macular Atrophy Caused by a Novel Recessive PDE6C
Mutation (p.E591K). Ophthalmic Genet. 2015;36:137-44
Kato Y, Tsunoda K, Fujinami K, Iwata T, Saga M, Oguchi Y.
Association of Retinal Artery and Other Inner Retinal Structures With Distribution of
Tapetal-like Reflex in Oguchi's Disease. Invest Ophthalmol Vis Sci. 2015;56:2162-72
Iwata T.
Author Response: Postnatal Overexpression of the Human ARMS2 Gene Does Not
Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models. Invest
Ophthalmol Vis Sci. 2015; 56:1389
Kuniyoshi K, Sakuramoto H, Yoshitake K, Ikeo K, Furuno M, Tsunoda K, Kusaka S,
Shimomura Y, Iwata T. Reduced rod electroretinograms in carrier parents of two
Japanese siblings with autosomal recessive retinitis pigmentosa associated with PDE6B
gene mutations. Doc Ophthalmol. 2015;131:71-9
― 221 ―
Iejima D, Itabashi T, Kawamura Y, Noda T, Yuasa S, Fukuda K, Oka C, Iwata T. HighTemperature Requirement A Serine Peptidase 1 Gene is Transcriptionally Regulated by
Insertion/Deletion Nucleotides Located at the 3 Prime End of Age-Related Maculopathy
Susceptibility 2 Gene in Patients with Age-Related Macular Degeneration. The Journal
of Biological Chemistry 2015;290:2784-97
Impact Factor: 4.573
Kuniyoshi K, Ikeo K, Sakuramoto H, Furuno M, Yoshitake K, Hatsukawa Y, Nakao A,
Kusaka S, Shimomura Y, Iwata T.
Novel nonsense and splice site mutations in CRB1 gene in two Japanese patients with
early-onset
retinal
dystrophy
Documenta
Ophthalmologica.
Documenta
Ophthalmologica 2015;130:49-55
࠙⥲ㄝࠚ
Iejima D, Nakayama M, Iwata T
HTRA1 Overexpression Induces the Exudative Form of Age-Related Macular
Degeneration.
Age-Related Macular Degeneration: Prevalence, Risk Factors and Clinical Management.,
Nova Science Publishers, 37-51, 2015.
࠙Ꮫ఍ࠊ◊✲఍ࠊᣍᚅㅮ₇࡛ࡢⓎ⾲ࠚ
ᒾ⏣ ᓅ
Genes and Molecular Mechanisms of Retinal Disease
Ἀ⦖⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫ ⚄⤒Ⓨ⏕ࣘࢽࢵࢺ୺ദࢭ࣑ࢼ࣮
Takeshi Iwata, Subhabrata Chakrabarthy, Sayan Basu, Sushmita Kaushik
Audacious goals for Translational Research of Genetic Eye Disease
73th AIOC 2015, New Delhi, 2015.2.6
Gyan Prakash, S. Natarajan, Takeshi Iwata, Subho Chakrabarti, Bishwanath Pal
Asian Eye Genetics Consortium (AEGC)
73th AIOC 2015, New Delhi, 2015.2.7
Takeshi Iwata
࣭NISO-NEI collaborative research programs, past and future
࣭Asian Eye Genetics Consortium, Genetic research programs covering the entire Asia
Asia-ARVO 2015, Yokohama, 2015.2.16-19
― 222 ―
ᒾ⏣ ᓅ
⥙⭷⑌ᝈࡢ⑓ᅉ࡜⑓ែᶵᗎࡢゎ᫂
ᒣཱྀ኱Ꮫ ➨ 14 ᅇ㧗ḟ⤫ྜឤぬჾ་⒪◊✲఍ ≉ูㅮ₇
Takeshi Iwata
࣭Japanese Whole Exome Project for Hereditary Retinal Diseaseࠖ
࣭Molecular Mechanism of Normal Tension Glaucoma by Optineurin Mutation
APAO2015 ᗈᕞ 2015.4.3
ᒾ⏣ ᓅ
Eyeing the Aging Problem
⡿ᅜၟᕤ఍㆟ᡤ ㅮ₇఍ ᮾி࢔࣓ࣜ࢝ࣥࢡࣛࣈ 2015.4.7
Takeshi Iwata
ࠕOverview of eye genetics in Asia and the way of forwardࠖ
ࠕMolecular mechanism of NTG by E50K mutation in optineurin gene
ARVO 2015 Annual Meeting, Denver, 2015.5.5
ᒾ⏣ ᓅ
㑇ఏᛶ⥙⭷⑌ᝈࡢཎᅉ㑇ఏᏊࡢ᥈⣴ࠊࢹ࣮ࢱ࣮࣋ࢫࡢᵓ⠏ࡑࡋ࡚ᅜ㝿༠ຊ
᪥ᮏ⥙⭷Ⰽ⣲ኚᛶ⑕༠఍ ♫ဨ⥲఍ ་⒪ㅮ₇ 2015.6.27
ᒾ⏣ ᓅ
⥙⭷Ⰽ⣲ኚᛶࢆྵࡴ㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ඲㑇ఏᏊゎᯒ࡜Ⓨ⑕ᶵᗎࡢゎ᫂
᪥ᮏ⥙⭷Ⰽ⣲ኚᛶ⑕༠఍ ᮾிᨭ㒊⥲఍ ་⒪ㅮ₇ 2015.7.5
Takeshi Iwata
Genes and Molecular Mechanisms of Retinal Disease
China –Arab States Expo 2015, Ningxa, China 2015.9.12
Takeshi Iwata
Japan Consortium for Hereditary Retinal Diseases / Characterization of HTRA1
Transcription and Development of CNV Mouse Model
National Eye Institute, NIH, Bethesda, 2015.10.5
Takeshi Iwata
Introduction of the Asian Eye Genetics Consortium and the Japanese Consortium for
Hereditary Retinal Disease
2nd Congress of ASEAN Ophthalmology Society, Ha Noi, 2015.10.29
― 223 ―
Daisuke Iejima, Mao Nakayama, Takeshi Itabashi, Yuich Kawamura, Masakazu
Akahori, Toru Noda, Takeshi Iwata
Characterization of HTRA1 Promoter in Patients with Exudative Age-Related Macular
Degeneration.
2015 Asia ARVO, Yokohama, Japan, Feb. 17, 2015.
ᐙᓥ኱㍜㸪୰ᒣ┿ኸ㸪ᕝᮧ㞝୍㸪㔝⏣ᚭ㸪ᒾ⏣ᓅ
ࠕⁱฟᆺຍ㱋㯤ᩬኚᛶࡢឤཷᛶ㑇ఏᏊ㡿ᇦ ARMS2/HTRA1 ࡢ㌿෗ᶵ⬟ゎᯒࠖ
➨ 19 ᅇ║⛉ศᏊ⏕≀Ꮫ◊✲఍㸪 ᒱ㜧㸪 2015 ᖺ 2 ᭶ 28 ᪥
Daisuke Iejima, Mao Nakayama, Toru Noda, Atsushi Mizota and Takeshi Iwata
Human HTEA1 expression is enhanced by indel mutation in the HTRA1 regulatory
element region.
ARVO 2015, Denver, USA, 2015.5.6
Akiko Suga, Kazuyo Sadamoto, Momo Fujii, Michiko Mandai, Masayo Takahashi,
Takeshi Iwata
Proliferation potential of Müller glia after retinal damage varies between mouse strains
ARVO 2015 Annual Meeting, Denver, USA, 2015.5.7
㡲㈡ ᬗᏊࠊᒾ⏣ ᓅ
ࠕ඲࢚ࢡࢯࣥゎᯒ࡟ࡼࡿ⥙⭷Ⰽ⣲ኚᛶࡢ᪂つཎᅉ㑇ఏᏊࡢྠᐃ࡜ኚ␗ࡢᶵ⬟ゎᯒࠖ
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ ⱝᡭ◊✲⪅Ⓨ⾲఍ࠊᮾி㒔ࠊ2015 ᖺ 11 ᭶ 2 ᪥
ᕝᮧ㞝୍ࠊ⸨ᕳᣅ㑻ࠊྜྷṊ࿴ᩄࠊゅ⏣࿴⦾ࠊ㡲㈡ᬗᏊࠊᮧୖ ᬗࠊᒾ⏣ ᓅ
ON ᆺ཮ᴟ⣽⬊␗ᖖࢆక࠺㯤ᩬኚᛶᐙ⣔ࡢཎᅉ㑇ఏᏊゎᯒ
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ⱝᡭ◊✲⪅Ⓨ⾲఍ࠊᮾி㒔ࠊ2015ࠊ2015 ᖺ 11 ᭶ 2 ᪥
― 224 ―
㻌
㻌
㻌
㻌
䠘୺ദ䝅䞁䝫䝆䜴䝮䛺䛹䠚㻌
㻌
― 225 ―
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ ⱝᡭ◊✲⪅Ⓨ⾲఍ ࣉࣟࢢ࣒ࣛ
᪥᫬㸸ᖹᡂ ᖺ ᭶ ᪥᭶ 㸸㹼㸸
ሙᡤ㸸⑓Ჷ఍㆟ᐊ ₇㢟 Ⓨ⾲ ศ ㉁␲ᛂ⟅ ศ
ົྎ ⱥᶞ
a ஦ົ㐃⤡ ࢭࢵࢩࣙࣥ㸯 ᗙ㛗
ᒾ⏣ ᓅ㸦ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㛗㸧
㸸a 21 ᆺ཮ᴟ⣽⬊␗ᖖࢆక࠺㯤ᩬኚᛶᐙ⣔ࡢཎᅉ㑇ఏᏊゎᯒ
ᕝᮧ 㞝୍ 㸦ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㸧
㸸a ඲࢚ࢡࢯࣥゎᯒ࡟ࡼࡿ⥙⭷Ⰽ⣲ኚᛶࡢ᪂つཎᅉ㑇ఏᏊࡢྠᐃ࡜
ኚ␗ࡢᶵ⬟ゎᯒ
㡲㈡ ᬗᏊ 㸦ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㸧
㸸a ࢤࣀ࣒࢖ࣥࣉࣜࣥࢸ࢕ࣥࢢ࡜ඛኳ␗ᖖ⑕ೃ⩌
ᒣ⃝ ୍ᶞ 㸦ᑠඣ⛉㸧
㸸a ḟୡ௦ࢩ࣮ࢡ࢚ࣥࢫ࡛ぢࡘ࠿ࡗࡓ /2;+' 㑇ఏᏊࡢ᪂つኚ␗࡜
ࡑࡢศᏊ⑓ែ
㞴Ἴ ୍ᚨ 㸦⫈ぬᖹ⾮ぬ◊✲㒊㸧
ࢭࢵࢩࣙࣥ㸰 ᗙ㛗
ᑿ⸨ ㄔྖ㸦⮫ᗋ␿Ꮫ◊✲ᐊ㛗㸧
㸸a ᩚᙧእ⛉≉᭷ࡢ㌿ಽ࣭㌿ⴠῶᑡ࡬ࡢྲྀࡾ⤌ࡳ
㹼㌿ಽ࣭㌿ⴠせᅉศᯒࡢ⤖ᯝࢆ㏻ࡋ࡚㹼
ᩧ⸨ ᗣ୍ 㸦┳ㆤ࣭% ⑓Ჷ㸧
㸸a ከ⫋✀࡟ᑐࡍࡿ᪂᥇⏝⪅ᑐ㇟ឤᰁ㜵Ṇᩍ⫱ࡢᐇ㊶ ̿ࢩ࣑࣮ࣗࣞࢩࣙࣥࢺ࣮ࣞࢽࣥࢢࢆ⏝࠸࡚̿
㯮⏣ ⨾ᚨ 㸦┳ㆤ࣭་⒪Ᏻ඲⟶⌮㒊㸧
㸸a 㝔እᚰ⫵೵Ṇ౛࡟࠾ࡅࡿ᪤ Ⓚ࠾ࡼࡧ⭈㞀ᐖ࡜⏕Ꮡ㏥㝔࡜ࡢ㛵㐃
⚟⏣ ṇ 㸦ᚠ⎔ჾෆ⛉㸧
㸸a 6 ≧⤖⭠᤬㌿⑕࡟ᑐࡍࡿෆど㙾ⓗᩚ᚟ࡢព⩏࡟ࡘ࠸࡚ࡢ᳨ウ
ᖹ⏣ ဴ 㸦ᾘ໬ჾ⛉㸧
ࢭࢵࢩࣙࣥ㸱
ᗙ㛗
ゅ⏣ ᫭୍㸦ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊㛗㸧
㸸a ேᕤ⫠㛛࠿ࡽࡢ኱⭠ &7 ᛂ⏝
┦⃝ ຌ ᨺᑕ⥺⛉
㸸a ࣟ࣎ࢵࢺᨭ᥼᰿἞ⓗ๓❧⭢඲᦬㝖⾡࡟࠾ࡅࡿ⾡୰ࡢ║ᅽୖ᪼࡜ ୕ḟඖ๓║㒊 2&7 ࢆ⏝࠸ࡓ⾡๓ࡢ๓ᡣ῝ᗘ࡟㛵ࡍࡿ᳨ウ
Ỉ㔝 㞞᫓ 㸦║⛉㸧
㸸a ႃ㢌⫗ⱆ⭘ࡢಖᏑⓗ἞⒪ᡂ⦼
ᑠᯘ ⌮㤶 㸦ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊㸧
㸸a 㛢఍ࡢࡈᣵᣜ
Ṋ⏣ ⣧୕ ⑓㝔㛗
࣭࣭࣭࣭ᚋ∦௜ࡅ㸦 ࡲ࡛࡟᪋㘄㸧࣭࣭࣭࣭
a ᠓ぶ఍ ໭ࡢཔᡣ
― 226 ―
㻌
㻌
㻌
㻌
䊢㻌 ◊✲㈝㻌
㻌
ᖹᡂ27ᖺᗘ◊✲㈝
1) ᩥ㒊⛉Ꮫ◊✲㈝
㸺ᇶ┙◊✲㸦㹀㸧㸼
Ỉ㊊ࠉ㑥㞝
ࣄࢺiPS⣽⬊࡜ᑠᆺ㟋㛗㢮ࢥ࣐࣮ࣔࣥࣔࢭࢵࢺࢆ⏝࠸ࡓ⼗∵᭷ẟ⣽⬊
෌⏕ࡢ๓⮫ᗋ᳨ウ
ᒾ⏣ࠉᓅ
㟋㛗㢮ࣔࢹࣝࢆ⏝࠸ࡓࢻ࣮ࣝࢮࣥ⏕ᡂᶵᗎࡢゎ᫂࡜ண㜵⸆ࡢ㛤Ⓨ
6,240,000෇
ຊ୸ࠉ⿱
⫈ぬᮎᲈ࠾ࡼࡧ⬻ᖿ࡟ࡼࡿಙྕᢳฟࡢ⏕⌮ᶵᵓ㸸ࢥ࢘ࣔࣜࢆࣔࢹࣝ࡜
ࡋࡓ◊✲
9,230,000෇
ᯇᮧࠉ┿ྖ
⬤ᙅ㧗㱋⪅ࡢࢣ࢔⛣⾜᫬࡟࠾ࡅࡿデ⒪᝟ሗఏ㐩ࡢࡓࡵࡢᶆ‽ⓗࣇ࢛࣮
࣐ࢵࢺ㛤Ⓨ
1,430,000෇
஬ᓥࠉྐ⾜
ෆ⪥౵ᐖཷᐜయ௬ㄝ࡟ᇶ࡙࠸ࡓ∦㢌③㛵㐃ࡵࡲ࠸ࡢ⑓ែゎ᫂ࡢࡓࡵࡢ
ᇶ♏ⓗ◊✲
1,950,000෇
ົྎࠉⱥᶞ
⼗∵⚄⤒పᙧᡂࡢ᪂つཎᅉೃ⿵ZBTB10ࡢෆ⪥Ⓨ⏕࡟࠾ࡅࡿᶵ⬟ゎᯒ
1,560,000෇
㞴Ἴࠉ୍ᚨ
࣌ࣥࢻࣞࢵࢻ⑕ೃ⩌ࡢཎᅉ࡜࡞ࡿSLC26A4ࡢ㧗㢖ฟኚ␗࡟ࡼࡿᵓ㐀
㞀ᐖᶵᗎࡢゎ᫂
1,430,000෇
ᐙᓥࠉ኱㍜
ⁱฟᆺຍ㱋㯤ᩬኚᛶ࡟࠾ࡅࡿHTRA1㑇ఏᏊ࡟㉳ᅉࡍࡿ⾑⟶᪂⏕࣓࢝
ࢽࢬ࣒ࡢゎᯒ
1,430,000෇
㡲㈡ࠉᬗᏊ
ᡂయ࣐࢘ࢫ࣑࣮ࣗࣛࢢࣜ࢔⣽⬊࡬ࡢ㑇ఏᏊᑟධ࡟ࡼࡿin vivo ⥙⭷⚄
⤒⣽⬊෌⏕
1,170,000෇
ⴠྜࠉ༤Ꮚ
MUSE⣽⬊⛣᳜ࡣ⓶⭵๰യ἞⒵ࢆಁ㐍ࡋࠊ⓶⭵ᵓ㐀ࢆ෌⏕ࡍࡿ࠿㸽
1,690,000෇
195,000෇
㸺ᇶ┙◊✲㸦C㸧㸼
⸨஭ࠉṇே
(ศᢸ)
㢌㢕㒊⒴࡟࠾ࡅࡿᶵ⬟ Ꮡࢆ┠ᣦࡋࡓ㞟Ꮫⓗ἞⒪࡟ᑐࡍࡿࣂ࢖࣐࣮࢜
࣮࢝ࡢ㛤Ⓨ
650,000෇
ᑿ⸨ࠉㄔྖ
(ศᢸ)
᪥ᮏᆺ೔⌮ࢥࣥࢧࣝࢸ࣮ࢩࣙࣥయไ࡜೔⌮ࣉࣟࣇ࢙ࢵࢩࣙࢼࣝ⫱ᡂ࡟
㛵ࡍࡿ◊✲
260,000෇
ᯘࠉ⿱ྐ
(ศᢸ)
⫈ᖹ⾮ぬ่⃭࡟ᑐࡍࡿ㥆໬ࢆᣦᶆ࡜ࡋࡓ๓ᗞᛶ∦㢌③ࡢᐈほⓗデ᩿ἲ
ࡢ☜❧
65,000෇
༡ࠉಟྖ㑻
Ᏻ㟼᫬㹤MR1ࢆ⏝࠸ࡓ⫈ぬ␗ᖖឤ⬻ࢿࢵࢺ࣮࣡ࢡࡢゎ᫂ཬࡧࡑࡢ୰ᯡ
ไᚚ
1,560,000෇
ຍᡃ ྩᏕ
ேᕤෆ⪥࠾ࡼࡧ⿵⫈ჾ⿦⏝⪅ࡢ㡢※ᐃ఩ࠊ୧⪥ศ㞳⬟ࠊ୧⪥ྜᡂ⬟ࡢ
◊✲
1,040,000෇
ᮌᮧࠉ⨾࿴Ꮚ
㧗ศᏊ࣑ࢭࣝᆺࢼࣀ࣓ࢹ࢕ࢩࣥࢆ⏝࠸ࡓ㠉᪂ⓗ࡞㢌㢕㒊⭘⒆἞⒪ἲࡢ
㛤Ⓨ
910,000෇
ᚨ୸ࠉ⿱
HPV㝧ᛶ㢌㢕㒊⒴࡟࠾ࡅࡿDNA࣓ࢳࣝ໬ࢆᣦᶆ࡜ࡋࡓⓎ⒴࣓࢝ࢽࢬ
࣒ࡢゎ᫂
ఀ⸨ࠉ᠇἞
(ศᢸ) ⼗∵⚄⤒᰾࡟࠾ࡅࡿ㡢ኌ᝟ሗฎ⌮ᶵᵓࡢゎ᫂
1,040,000෇
130,000෇
ゅ⏣ࠉ᫭୍
Ⓨኌ⫈ぬࣇ࢕࣮ࢻࣂࢵࢡࡢ୰ᯡㄪ⠇ࡢ⏕⌮ⓗゎ᫂
1,560,000෇
ᑿ⸨ࠉㄔྖ
ࠕ࡜ࡶ࡟⪃࠼ࡿ࢖ࣥࣇ࢛࣮࣒ࢻ࣭ࢥࣥࢭࣥࢺࠖᐇ㊶ࣔࢹࣝࡢᥦ♧࡜᭷
ຠᛶࡢ᳨ド
1,560,000෇
㧗㱋⪅ࡢࢣ࢔ෆᐜࢆỴᐃࡍࡿ㝿ࡢ⮫ᗋ᥎ㄽ࡟ᑐࡍࡿᩍ⫱ࣉࣟࢢ࣒ࣛࡢ
᪉ྥᛶ
520,000෇
బࠎᮌࠉ┿⌮Ꮚ
ㄆ▱⑕Ⓨ⑕ண ࣂ࢖࣐࣮࣮࢜࢝࡜ࡋ࡚ࡢ⥙⭷ᙧ≧ゎᯒࡢᛂ⏝㸸║⛉␿
Ꮫࢥ࣮࣍ࢺ◊✲
1,430,000෇
Ỉ㊊ࠉ㑥㞝
⼗∵᭷ẟ⣽⬊࣭ࡽࡏࢇ⚄⤒⠇⣽⬊ࡢ㐜Ⓨᛶ⬺ⴠ࣓࢝ࢽࢬ࣒ࡢゎ᫂
1,690,000෇
➉⭜ࠉⱥᶞ
Auditory NeuropathyࡢCHIRP㡢⼗㟁ᅗ࡜VEMP࡟ࡼࡿ◊✲
1,040,000෇
ゅ⏣ࠉ࿴⦾
OPA1㑇ఏᏊኚ␗ࢆ᭷ࡍࡿඃᛶど⚄⤒ጤ⦰⑕࡟࠾ࡅࡿ║⛉ⓗ࠾ࡼࡧ඲
㌟ⓗ⑕≧ࡢ◊✲
1,820,000෇
ᑿ⸨ࠉㄔྖ
஬ᓥࠉྐ⾜
(ศᢸ)
(ศᢸ)
㸱ḟඖືⓗࣉࣛࢵࢺࣇ࢛࣮࣒ࢆ⏝࠸ࡓ᪂ࡓ࡞ᖹ⾮ᶵ⬟ࢺ࣮ࣞࢽࣥࢢἲ
ࡢ☜❧
― 227 ―
65,000෇
㸺ᣮᡓⓗⴌⱆ◊✲㸼
ᒾ⏣ࠉᓅ
㑇ఏᛶ⥙⭷⑌ᝈ࢝ࢽࢡ࢖ࢨࣝࡢస〇࡜ࡑࡢ⑓⌮Ꮫⓗゎᯒ
3,640,000෇
ᒣ⃝ࠉ୍ᶞ
㑇ఏᛶஙࡀࢇ࣭༸ᕢࡀࢇ࡟࠾࠸࡚࣓ࢳࣝ໬࣭ࣄࢻࣟ࢟ࢩ࣓ࢳࣝ໬ࡀᯝ
ࡓࡍᙺ๭ࡢゎ᫂
2,210,000෇
Ỉ㊊ࠉ㑥㞝
(ศᢸ) ࣄࢺES/iPS⣽⬊⏤᮶ࡢෆ⪥⣽⬊ࢆ⏝࠸ࡓ⸆๣ࢫࢡ࣮ࣜࢽࣥࢢ⣔ࡢᵓ⠏
130,000෇
࣓ࢳࣝ໬␗ᖖ࡟㉳ᅉࡍࡿඛኳ␗ᖖ⑕ೃ⩌࡟࠾࠸࡚ࣄࢻࣟ࢟ࢩ࣓ࢳࣝ໬
ࡀᯝࡓࡍᙺ๭ࡢゎ᫂
6,500,000෇
ᯘࠉ⿱ྐ
⼗∵⤌⧊≉␗ⓗ࣐ࢡࣟࣇ࢓࣮ࢪࡢᶵ⬟ゎᯒ࡜ឤ㡢㞴⫈Ⓨ⑕࣓࢝ࢽࢬ࣒
࡟㛵ࡍࡿ◊✲
2,470,000෇
⚟஭ࠉṇᶞ
どぬ࠿ࡽࡢ㧗ḟᶵ⬟ホ౯ἲࡢ᳨ウ
㸺ⱝᡭ◊✲A㸼
ᒣ⃝ࠉ୍ᶞ
㸺ⱝᡭ◊✲㹀㸼
910,000෇
㸺ᅜ❧◊✲㛤Ⓨἲே⛉Ꮫᢏ⾡᣺⯆ᶵᵓ ጤク◊✲㛤Ⓨ㈝㸼
ᾆᒸࠉಇኵ
ෆど㙾἞⒪࡛⏕ࡌࡓᾘ໬⟶ቨࡢ✸Ꮝࢆయ ◳໬ᛶࢤ࡛ࣝ⡆᫆࠿ࡘ☜ᐇ
࡟⿕そࡍࡿ἞⒪ᢏ⾡ࡢ㛤Ⓨ
3,690,700෇
㛫᥋⤒㈝ྵࠉࠉࠉࠉᑠィ
61,215,700෇
2) ཌ⏕ປാ⛉Ꮫ◊✲㈝
㸺ㄆ▱⑕ᑐ⟇⥲ྜ◊✲஦ᴗ㸼
Ᏻᮧࠉ㔛⤮
㯞㓉᪉ἲࡀ⾡ᚋㄆ▱ᶵ⬟࡟୚࠼ࡿᙳ㡪࡟ࡘ࠸࡚ࡢ◊✲
2,622,000෇
㸺㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ㸼
ຍᡃࠉྩᏕ
(ศᢸ) 㞴἞ᛶ⫈ぬ㞀ᐖ࡟㛵ࡍࡿㄪᰝ◊✲
600,000෇
ᯇỌࠉ㐩㞝
(ศᢸ) 㞴἞ᛶ⫈ぬ㞀ᐖ࡟㛵ࡍࡿㄪᰝ◊✲
600,000෇
ᯇỌࠉ㐩㞝
(ศᢸ)
ᅜ㝿ᶆ‽࡟❧⬮ࡋࡓወᙧ⑕ೃ⩌㡿ᇦࡢデ⒪ᣦ㔪࡟㛵ࡍࡿᏛ㝿ⓗ࣭⥙⨶
ⓗ᳨ウ
700,000෇
㸺࢚࢖ࢬᑐ⟇ᨻ⟇◊✲஦ᴗ㸼
ᮏ⏣ ⨾࿴Ꮚ
(ศᢸ) HIVឤᰁ⑕ࡢ་⒪యไࡢᩚഛ࡟㛵ࡍࡿ◊✲
3,000,000෇
㸺㞀ᐖ⪅ᨻ⟇⥲ྜ◊✲஦ᴗ㸼
ᮏ⏣ࠉ⨾࿴Ꮚ
(ศᢸ) ⢭⚄㞀ᐖ⪅ࡢᆅᇦ⏕άᨭ᥼ࡢᅾࡾ᪉࡜ࢩࢫࢸ࣒ᵓ⠏࡟㛵ࡍࡿ◊✲
㛫᥋⤒㈝ྵࠉࠉࠉࠉᑠィ
2,000,000෇
9,522,000෇
3) ᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓጤク◊✲㛤Ⓨ㈝
㸺㞴἞ᛶ⑌ᝈᐇ⏝໬◊✲஦ᴗ㸼
ᒾ⏣ࠉᓅ
㑇ఏᛶ⥙⬦⤡⭷⑌ᝈࡢ⏕యヨᩱࡢ཰㞟࣭⟶⌮࣭ᥦ౪࡜⑓ែゎ᫂
ᯇỌࠉ㐩㞝
Pendred⑕ೃ⩌⏤᮶⑌ᝈiPS⣽⬊ࢆ⏝࠸ࡓ⑓ែ⏕⌮࡜᪂つ἞⒪ᶆⓗࡢ
(ศᢸ) ᥈⣴࠾ࡼࡧiPS⣽⬊ᢏ⾡ࢆ⏝࠸ࡓ⑕౛ẖࡢ⸆๣ឤཷᛶࡢ஦๓ண ࡟㛵
ࡍࡿ◊✲
ᒣ⃝ࠉ୍ᶞ
(ศᢸ)
࢖ࣥࣉࣜࣥࢸ࢕ࣥࢢ␗ᖖ⑕Ⓨ⑕࠾ࡼࡧྜే⑕Ⓨ⑕࣓࢝ࢽࢬ࣒ࡢゎ᫂㸸
ᝈ⪅⏤᮶iPS⣽⬊ࢆ⏝࠸࡚ࡢ◊✲
― 228 ―
110,000,000෇
3,000,000෇
1,950,000෇
㸺㞀ᐖ⪅ᑐ⟇⥲ྜ◊✲㛤Ⓨ஦ᴗ㸼
᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢ࡟࠾ࡅࡿAuditory Neuropathy Spectrum
Disorders⑕౛ࡢ㛗ᮇ㏣㊧◊✲
ຍᡃࠉྩᏕ
ᯇỌࠉ㐩㞝
(ศᢸ) ᪂ࡋ࠸㞴⫈㑇ఏᏊデ᩿ࢩࢫࢸ࣒ࡢ㛤Ⓨ࠾ࡼࡧ⮫ᗋᛂ⏝࡟㛵ࡍࡿ◊✲
9,000,000෇
650,000෇
㸺་⒪ᶵჾ㛤Ⓨ᥎㐍◊✲஦ᴗ㸼
ゅ⏣ࠉ࿴⦾
ᅾᏯ་⒪࡟ᛂ⏝ྍ⬟࡞⡆᫆ᆺ║ᗏほᐹ⿦⨨ࡢ㛤Ⓨ
20,800,000෇
㸺᪩ᮇ᥈⣴ⓗ࣭ᅜ㝿Ỉ‽⮫ᗋ◊✲஦ᴗ㸼
Ṋ⏣ࠉ⣧୕
(ศᢸ)
ࠕ⮫ᗋ◊✲ရ㉁☜ಖయไᩚഛ⑓㝔ࠖࢆά⏝ࡋࡓᅜ㝿ᶆ‽ࡢ⮫ᗋ◊✲ࡢ
᥎㐍࡜᪂つ་⸆ရ࣭་⒪ᶵჾࡢ㛤Ⓨ࡟㛵ࡍࡿ◊✲
3,835,000෇
ゅ⏣ࠉ᫭୍
(ศᢸ)
ࠕ⮫ᗋ◊✲ရ㉁☜ಖయไᩚഛ⑓㝔ࠖࢆά⏝ࡋࡓᅜ㝿ᶆ‽ࡢ⮫ᗋ◊✲ࡢ
᥎㐍࡜᪂つ་⸆ရ࣭་⒪ᶵჾࡢ㛤Ⓨ࡟㛵ࡍࡿ◊✲
6,110,000෇
㸺㠉᪂ⓗࡀࢇ་⒪ᐇ⏝໬◊✲஦ᴗ㸼
⸨஭ࠉṇே
(ศᢸ)
㐍⾜㢌㢕㒊ࡀࢇ࡟ᑐࡍࡿ⾡ᚋ⿵ຓ⒪ἲࡢᶆ‽἞⒪☜❧ࡢࡓࡵࡢከ᪋タ
ඹྠ◊✲
1,000,000෇
⸨஭ࠉṇே
(ศᢸ)
㐍⾜ୖ㢡Ὕ⒴࡟ᑐࡍࡿ㉸㑅ᢥⓗືὀ໬Ꮫ⒪ἲࢆే⏝ࡋࡓᨺᑕ⥺἞⒪࡟
ࡼࡿ᪂つ἞⒪ἲ㛤Ⓨ࡟㛵ࡍࡿ◊✲
1,300,000෇
ⴙࠉ⠜᠇
(ศᢸ)
ࢺ࣮ࣞࢧࣅࣜࢸ࢕ࡢ☜ಖࡉࢀࡓ⥺※࡜⏬ീㄏᑟࢆ฼⏝ࡋࡓ㧗⥺㔞⋡ᑠ
⥺※἞⒪ࡢᶆ‽໬࡜㧗ᗘ໬ࡢ◊✲
400,000෇
㛫᥋⤒㈝ྵࠉࠉࠉࠉᑠィ 158,045,000෇
4)ࡑࡢ௚ࡢ◊✲㈝
㸺ࡀࢇ◊✲㛤Ⓨ㈝㸼
⸨஭ࠉṇே
(ศᢸ) 㢌㢕㒊ࡀࢇ࡟ᑐࡍࡿᶆ‽἞⒪☜❧ࡢࡓࡵࡢከ᪋タඹྠ◊✲
800,000෇
⸨஭ࠉṇே
(ศᢸ) 㢌㢕㒊⒴࡟ᑐࡍࡿ㞟Ꮫⓗ἞⒪࡜ࡋ࡚ࡢ໬Ꮫᨺᑕ⥺⒪ἲࡢ㛤Ⓨ
400,000෇
㸺ᖹᡂ27ᖺᗘබ┈㈈ᅋἲே⏕Ꮡ⛉Ꮫ◊✲ᡤ◊✲ຓᡂ㔠㸼
▱ぬ࣭ឤ᝟࣭ゝㄒ࡟ࡼࡿໟᣓⓗࢣ࢔ᢏ⾡ࡢᐇ㊶ᛂ⏝࡜ࡑࡢຠᯝ
ᮏ⏣ࠉ⨾࿴Ꮚ
800,000෇
㸺2015ᖺᗘ᪥ᮏᑠඣෆศἪᏛ఍ࠉᮍ᮶㛤ᣅ◊✲ຓᡂ㔠㸼
࣓ࢳࣝ໬␗ᖖ࡟㉳ᅉࡍࡿᑠඣඛኳ␗ᖖ⑕ೃ⩌࡟࠾࠸࡚ࣄࢻࣟ࢟ࢩ࣓ࢳ
ࣝ໬ࡀᯝࡓࡍᙺ๭ࡢゎ᫂
ᒣ⃝ࠉ୍ᶞ
1,000,000෇
㸺ᖹᡂ27ᖺᗘ㕥ᮌㅬ୕グᛕ་⛉Ꮫᛂ⏝◊✲㈈ᅋࠉຓᡂ㔠㸼
༡ࠉಟྖ㑻
⪁ேᛶ㞴⫈࡟ᑐࡍࡿࠊᏳ㟼᫬ fMRI ᶵ⬟ⓗ⤖ྜ࡟ᇶ࡙࠸ࡓ⫈ぬࣜࣁࣅ
ࣜࢸ࣮ࢩࣙࣥࡢ㛤Ⓨ
1,000,000෇
㛫᥋⤒㈝ྵࠉࠉࠉࠉᑠィ
4,000,000෇
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
7,070,000෇
5㸧ᅜ❧⑓㝔ᶵᵓඹྠ⮫ᗋ◊✲
㸺NHOࢿࢵࢺ࣮࣡ࢡඹྠ◊✲㸼
༡ࠉಟྖ㑻
⸨஭ࠉṇே
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
1,000,000෇
ᯇỌࠉ㐩㞝
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
100,000෇
஬ᓥࠉྐ⾜
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
100,000෇
ົྎࠉⱥᶞ
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
1,000,000෇
ຍᡃࠉྩᏕ
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
100,000෇
― 229 ―
ᵽཱྀࠉᬗᏊ
(ศᢸ)
៏ᛶ୰⪥⅖࡟࠾ࡅࡿ㞴ᇵ㣴ᚤ⏕≀ࡢ࣓ࢱࢤࣀ࣒ゎᯒ࡟ࡼࡿ᪂つ἞⒪㛤
Ⓨ࡟㛵ࡍࡿ◊✲
200,000෇
NHO⾑ᾮ࣭㐀⾑ჾ⑌ᝈࢿࢵࢺ࣮࣡ࢡཧຍ᪋タ࡟᪂ࡓ࡟Ⓨ⏕ࡍࡿከⓎ
ᛶ㦵㧊⭘ࡢணᚋ࡟㛵ࡍࡿ⮫ᗋⓗせᅉࢆ᫂ࡽ࠿࡟ࡍࡿࢥ࣮࣍ࢺ◊✲
Bᆺ⫢⅖࢘࢖ࣝࢫ࡟࠾ࡅࡿ᰾㓟࢔ࢼࣟࢢ⪏ᛶ㑇ఏᏊࡢゎᯒ࠾ࡼࡧ⪏ᛶ
(ศᢸ)
౛࡟ᑐࡍࡿrescuetherapyࡢ௓ධ
㠀࢔ࣝࢥ࣮ࣝᛶ⫢㞀ᐖ⏤᮶⫢⣽⬊⒴ࡢ᪩ᮇⓎぢ࠾ࡼࡧ༴㝤⩌ࡢᅖ࠸㎸
(ศᢸ)
ࡳࡢࡓࡵࡢ⾑୰࣐࣮࣮࢝᥈⣴
370,000෇
⳥ụࠉ┿኱
(ศᢸ) ᛴᛶ⫢⅖ࡢⓎ⏕≧ἣ࠾ࡼࡧ㔜⑕໬ࠊ๻⑕໬࡟㛵ࡍࡿᅉᏊ࡟㛵ࡍࡿ◊✲
580,000෇
ᮧ⏣ࠉ᭷ஓ
(ศᢸ) ⣽⬊デ᳨యࢆ⏝࠸ࡓங⒴⸆≀⒪ἲ㐺ᛂỴᐃࡢࡓࡵࡢᇶ♏◊✲
460,000෇
ᯇ஭ࠉဴ
(ศᢸ) ⣽⬊デ᳨యࢆ⏝࠸ࡓங⒴⸆≀⒪ἲ㐺ᛂỴᐃࡢࡓࡵࡢᇶ♏◊✲
460,000෇
἟⏣ࠉࡲࡍࡳ
(ศᢸ) ⣽⬊デ᳨యࢆ⏝࠸ࡓங⒴⸆≀⒪ἲ㐺ᛂỴᐃࡢࡓࡵࡢᇶ♏◊✲
340,000෇
ᶓᒣࠉ᫂ᘯ
⳥ụࠉ┿኱
⳥ụࠉ┿኱
(ศᢸ)
110,000෇
50,000෇
ຍᡃࠉྩᏕ
᪂⏕ඣ⫈ぬࢫࢡ࣮ࣜࢽࣥࢢࡢ᭷↓࡜ඛኳᛶ㞴⫈ඣࡢணᚋ࡜ࡢ㛵㐃ࡢゎ
᫂
4,460,000෇
ゅ⏣ࠉ᫭୍
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊ
ࡑࡢ᭷ຠᛶࡢ᳨ドࠉ㸫ၨⵚ࠿ࡽၨⓎ࡬㸫
7,200,000෇
Ṋ⏣ࠉ⣧୕
(ศᢸ)
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊࡑࡢ᭷
ຠᛶࡢ᳨ドࠉ㸫ၨⵚ࠿ࡽၨⓎ࡬㸫
100,000෇
஬ᓥࠉྐ⾜
(ศᢸ)
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊࡑࡢ᭷
ຠᛶࡢ᳨ドࠉ㸫ၨⵚ࠿ࡽၨⓎ࡬㸫
50,000෇
ᓥ⏣ࠉ㈗ಙ
(ศᢸ)
ࠕኌࡢ⾨⏕ᩍ⫱ࠖᝈ⪅ၨⓎ࡟ࡼࡿኌᖏ࣏࣮ࣜࣉࡢಖᏑⓗ἞⒪ࠊࡑࡢ᭷
ຠᛶࡢ᳨ドࠉ㸫ၨⵚ࠿ࡽၨⓎ࡬㸫
50,000෇
ᶓᒣࠉ᫂ᘯ
(ศᢸ) ከⓎᛶ㦵㧊⭘ࡢ㑇ఏᏊ␗ᖖ࡜἞⒪ຠᯝ࠾ࡼࡧணᚋ࡟㛵ࡍࡿ◊✲
ୖ㔝ࠉ༤๎
(ศᢸ)
෌Ⓨཪࡣ㞴἞ᛶࡢ㧗㱋⪅ࡧࡲࢇᛶ኱⣽⬊ᆺ㹀⣽⬊ࣜࣥࣃ⭘࡟ᑐࡍࡿ㹐
㸫㹅㹂㹎⒪ἲ࡟㛵ࡍࡿ➨㹇㹇┦ヨ㦂
250,000෇
⳥ụ ┿኱
(ศᢸ)
Cᆺ⫢⅖࢘࢕ࣝࢫ㥑㝖ᚋࡢ⫢⅖⑕/⥺⥔໬ᨵၿືែホ౯ࢆ┠ⓗ࡜ࡋࡓࠊ
⾑ΎmiRNAࣉࣟࣇ࢓࢖ࣜࣥࢢἲࡢ☜❧
75,000෇
⳥ụ ┿኱
(ศᢸ) ⏕యヨᩱࣂࣥࢡࢆ฼⏝ࡋࡓ⮬ᕫච␿ᛶ⫢⅖ࡢศᏊ␿Ꮫࢥ࣮࣍ࢺ◊✲
኱ᓥࠉஂ஧
(ศᢸ)
኱㭯ࠉὒ
(ศᢸ) ࡀࢇ࿘⾡ᮇᝈ⪅࡟࠾ࡅࡿཱྀ⭍⟶⌮௓ධຠᯝ࡟ཬࡰࡍண ᅉᏊࡢゎ᫂
ᯇỌࠉ㐩㞝
DPC᪋⾜⑓㝔࡟࠾ࡅࡿ⏬ീデ᩿ࢆ୰ᚰ࡜ࡋࡓ་⒪㈨※౑⏝ࡢຠ⋡ᛶホ
౯ࡢᣦ㔪సᡂࡢࡓࡵࡢ◊✲
240,000෇
280,000෇
412,000෇
80,000෇
ゝㄒ⫈ぬࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࡢྥୖࢆ┠ⓗ࡜ࡋࡓඛኳᛶ㞴⫈ࡢ㑇ఏⓗ
ཎᅉ࡜⏕ᚋ᪩ᮇࡢ⤒㐣ࡢゎ᫂㸫᪂ࡓ࡞◊✲᥎㐍㸫
17,510,000෇
ຍᡃࠉྩᏕ
(ศᢸ)
ゝㄒ⫈ぬࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࡢྥୖࢆ┠ⓗ࡜ࡋࡓඛኳᛶ㞴⫈ࡢ㑇ఏⓗ
ཎᅉ࡜⏕ᚋ᪩ᮇࡢ⤒㐣ࡢゎ᫂㸫᪂ࡓ࡞◊✲᥎㐍㸫
100,000෇
༡ࠉಟྖ㑻
(ศᢸ)
ゝㄒ⫈ぬࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࡢྥୖࢆ┠ⓗ࡜ࡋࡓඛኳᛶ㞴⫈ࡢ㑇ఏⓗ
ཎᅉ࡜⏕ᚋ᪩ᮇࡢ⤒㐣ࡢゎ᫂㸫᪂ࡓ࡞◊✲᥎㐍㸫
100,000෇
㎸ᒣ ಟ
(ศᢸ)
ゝㄒ⫈ぬࣜࣁࣅࣜࢸ࣮ࢩࣙࣥࡢྥୖࢆ┠ⓗ࡜ࡋࡓඛኳᛶ㞴⫈ࡢ㑇ఏⓗ
ཎᅉ࡜⏕ᚋ᪩ᮇࡢ⤒㐣ࡢゎ᫂㸫᪂ࡓ࡞◊✲᥎㐍㸫
200,000෇
ຍ⸨ࠉⰋ୍
ᶓᒣࠉ᫂ᘯ
ᾆᒸࠉಇኵ
75ᡯ௨ୖᚋᮇ㧗㱋⪅㠀ᑠ⣽⬊⫵⒴⑕౛ࡢᡭ⾡ᡂ⦼࡟㛵ࡍࡿ๓ྥࡁࡢከ
᪋タࢥ࣮࣍ࢺ◊✲
ᮍ἞⒪75ṓ௨ୖ㸦⛣᳜㠀㐺ᛂ㸧ࡢከⓎᛶ㦵㧊⭘ᝈ⪅ࢆᑐ㇟࡜ࡍࡿ
Bd/Ld஺᭰ᑟධ⒪ἲࡢᏳ඲ᛶ࣭᭷ຠᛶ࡟㛵ࡍࡿ⮫ᗋ◊✲
㠀ࢫࢸࣟ࢖ࢻᛶᢠ⅖⑕๣⥅⥆ᢞ୚ᝈ⪅࡟࠾ࡅࡿ⫶༑஧ᣦ⭠₽⒆෌Ⓨᢚ
(ศᢸ) ไຠᯝ࡟ᑐࡍࡿ࢚ࢯ࣓ࣉࣛࢰ࣮ࣝࠊࣛࣥࢯࣉࣛࢰ࣮ࣝࡢࣛࣥࢲ࣒໬ẚ
㍑ヨ㦂
(ศᢸ)
40,000෇
1,027,000෇
100,000෇
ᮧ⏣ࠉ᭷ஓ
(ศᢸ) ᅜ❧⑓㝔ᶵᵓ࡟࠾ࡅࡿ㐲㝸ங⭢⑓⌮デ᩿ࢿࢵࢺ࣮࣡ࢡᵓ⠏
500,000෇
ᯇ஭ࠉဴ
(ศᢸ) ᅜ❧⑓㝔ᶵᵓ࡟࠾ࡅࡿ㐲㝸ங⭢⑓⌮デ᩿ࢿࢵࢺ࣮࣡ࢡᵓ⠏
100,000෇
― 230 ―
ᒾ⏣ࠉᓅ
14,500,000෇
㑇ఏᛶ⥙⭷⑌ᝈ⏝㑇ఏᏊデ᩿࢟ࢵࢺࡢᐇ⏝໬◊✲
ᯇỌࠉ㐩㞝
(ศᢸ)
NICUඹ㏻ࢹ࣮ࢱ࣮࣋ࢫ࠿ࡽぢࡓᡂ⫱་⒪࡟࠾ࡅࡿ࿘⏘ᮇ་⒪ࡢホ౯
࡜␗ᖖ࡟ᑐࡍࡿ᪩ᮇⓎぢࠊ௓ධࡢ☜❧࡟㛵ࡍࡿ◊✲
800,000෇
㎸ᒣࠉಟ
(ศᢸ)
NICUඹ㏻ࢹ࣮ࢱ࣮࣋ࢫ࠿ࡽぢࡓᡂ⫱་⒪࡟࠾ࡅࡿ࿘⏘ᮇ་⒪ࡢホ౯
࡜␗ᖖ࡟ᑐࡍࡿ᪩ᮇⓎぢࠊ௓ධࡢ☜❧࡟㛵ࡍࡿ◊✲
1,000,000෇
ᒣ⃝ࠉ୍ᶞ
(ศᢸ)
NICUඹ㏻ࢹ࣮ࢱ࣮࣋ࢫ࠿ࡽぢࡓᡂ⫱་⒪࡟࠾ࡅࡿ࿘⏘ᮇ་⒪ࡢホ౯
࡜␗ᖖ࡟ᑐࡍࡿ᪩ᮇⓎぢࠊ௓ධࡢ☜❧࡟㛵ࡍࡿ◊✲
300,000෇
▮㔝ࠉᑛၨ
(ศᢸ)
ຍ㱋ᛶEpstein-Barr virus㛵㐃ࣜࣥࣃቑṪᛶ⑌ᝈ࡟࠾ࡅࡿPD-1/PD-L1
ࢩࢢࢼࣝࡢ⑓ែ࡬ࡢ㛵୚࡜ணᚋண ࡟㛵ࡍࡿゎᯒ
20,000෇
ᾆᒸࠉಇኵ
(ศᢸ)
኱⭠ෆど㙾἞⒪࡟࠾ࡅࡿ᪂つ⤒ཱྀᢠจᅛ๣⨨᥮ࡢ᭷⏝ᛶ࡜Ᏻ඲ᛶ࡟㛵
ࡍࡿከ᪋タඹྠ◊✲
200,000෇
ࠉࠉࠉࠉᑠィ
61,634,000෇
6㸧EBM᥎㐍◊✲㈝
㒯ࠉᮾᏕ
2ᆺ⢾ᒀ⑓ࢆేࡏᣢࡘ㧗⾑ᅽᝈ⪅࡟࠾ࡅࡿ࣓ࢺ࣑࣍ࣝࣥࡢᚰ⫧኱࣭ᚰ
ᶵ⬟࡟ᑐࡍࡿຠᯝࡢ᳨ウ
ຍ⸨ࠉⰋ୍
ႚ↮⪅ࠊ㠀ႚ↮⪅ࡢ⫵⒴⑓ᅉ࡟㛵ࡍࡿศᏊ␿Ꮫⓗ◊✲
኱ᓥࠉஂ஧
⫵⅖ࣜࢫࢡࢆ᭷ࡍࡿ㛵⠇࣐ࣜ࢘ࢳᝈ⪅ࢆᑐ㇟࡜ࡋࡓ23౯⫵⅖⌫⳦࣡ࢡ
ࢳࣥ㸦PPV)ࡢ᭷⏝ᛶ᳨ドࡢࡓࡵࡢRCT
240,000෇
ᵻᒣࠉᖾᙪ
㓟⣲ᢞ୚࡟ࡼࡿᚰ⮚࢝ࢸ࣮ࢸࣝᚋ㐀ᙳ๣⭈⑕ࡢண㜵ຠᯝ࡟㛵ࡍࡿ◊✲
660,000෇
ᯇ஭ࠉဴ
㑇ఏᛶஙࡀࢇ࣭༸ᕢࡀࢇࡢ㑇ఏᏊゎᯒ࡟ࡼࡿ࣮࢜ࢲ࣮࣓࢖ࢻ་⒪ࡢᐇ
⌧
3,000,000෇
ᑠィ
4,240,000෇
― 231 ―
250,000෇
90,000෇
㻌
㻌
㻌
㻌
䊣㻌 ⤌⧊⾲㻌
㻌
― 233 ―
ᒾ⏣ࠉᓅ
ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊㛗
ゅ⏣ࠉ᫭୍
ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊㛗
⸨஭ࠉṇே
⫈ぬ࣭ᖹ⾮ぬ◊✲㒊㛗
どぬ◊✲㒊㛗
ゅ⏣ࠉ࿴⦾
㸦ࢭࣥࢱ࣮㛗ే௵㸧
ᨻ⟇་⒪௻⏬◊✲㒊㛗
㒊㛗
ྡ㄃ࢭࣥࢱ࣮㛗ࠉࠉࠉࠉࠉࠉࠉຍᡃࠉྩᏕ
Ṋ⏣⣧୕
஦ົྲྀᢅ
ࢭࣥࢱ࣮㛗
ᵻᒣࠉᖾᙪ
ゅ⏣ࠉ࿴⦾
⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ
どぬ⏕⌮Ꮫ◊✲ᐊ
ᒾ⏣ࠉᓅ㸧
どぬ⏕≀Ꮫ◊✲ᐊ
⮫ᗋ◊✲ࢭࣥࢱ࣮஦ົᐊ
ᒾ⏣ࠉᓅ㸧
㸦ゅ⏣ࠉ᫭୍㸧
Ⓨ⏕་Ꮫ◊✲ᐊ
⚄⤒⏕≀Ꮫ◊✲ᐊ
㸦ゅ⏣ࠉ᫭୍㸧
㸦ゅ⏣ࠉ᫭୍㸧
ⴠྜࠉ༤Ꮚ
ࠉ஬ᓥࠉྐ⾜ࠉ
ᯇỌࠉ㐩㞝
㡢ኌ࣭ゝㄒࢥ࣑ࣗࢽࢣ࣮
ࢩࣙࣥ◊✲ᐊ
௦⏝⮚ჾ㛤Ⓨ◊✲ᐊ
෌⏕་⒪◊✲ᐊ
ᖹ⾮ぬ㞀ᐖ◊✲ᐊ
⫈ぬ㞀ᐖ◊✲ᐊ
࣮ࣟࣅࢪࣙࣥ◊✲ᐊ
㔝⏣ࠉᚭ
ᩧ⸨ྐ㑻
ᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺᢏ⾡
ᛂ⏝◊✲ᐊ
║⛉␿Ꮫ◊✲ᐊ
ᮏ⏣ࠉ⨾࿴Ꮚ
ᑿ⸨ࠉㄔྖ
ᐊ㛗
་⒪⤒Ⴀ᝟ሗ࣭㧗㱋⪅ࢣ࢔
◊✲ᐊ
⮫ᗋ␿Ꮫ◊✲ᐊ
◊✲ᐊ
࣭ᱵ⏣⛱Ꮚ
࣭ᐙᓥ኱㍜
࣭ᒸᮏᬗᏊ
࣭%ULDQ35RVVPLOOHU
࣭ົྎⱥᶞ
࣭㞴Ἴ୍ᚨ
ὶື◊✲ဨ
࣭బࠎᮌᚭ
࣭㛵ᮏⲮኴ㑻
࣭ෆ⸨⌮ᜨ
࣭すᒣ⪔୍㑻
࣭㔝ᮧົ
࣭⸨ᕳⴥᏊ
࣭ᒸࠉឡᏊ
࣭㤿ሙඃ
࣭⩚⏕᪼
࣭Ọ஭㑈ᩯ
࣭ᑠᯈᶫ⨾㤶
࣭㈏㔝ᙬᏊ
࣭ᮌᮧዉὠᏊ
࣭ቑ⏣ṇḟ
࣭ྜྷ὾ᆂ♸
࣭ᑿ௰❶⏨
࣭ᑠᯘ⌮㤶
࣭ᒾᮧᆒ
࣭ᡞ㇂Ⓩ㈗Ꮚ
࣭ఀ⸨⠜
࣭ᆏᮏᖾኈ
࣭ᓥ⏣㈗ಙ
࣭኱཭❶Ꮚ
࣭ᑠ⃝ᏹஅ
࣭ᮌཎᙬᏊ
࣭Ώ㒊㧗ஂ
࣭࿴బ㔝ᾈ୍㑻
࣭໭ᑿᜤᏊ
࣭ᒣᮏಟᏊ
࣭ᚋ⸨ࠉ⪽
࣭⚟஭ṇᶞ
࣭ᖹᙧᑑᙯ
࣭⛙ᮍ⛥
࣭Ỉ㔝჆ಙ
࣭▼஭཭㔛
࣭㇂ᆅࠉ㇏
࣭▮ᮌᗣே
࣭▮㔝ᑛၨ
࣭᳃ࠉ᭸᭷
࣭ᒣୗࠉ༤
࣭⯞ὠὒᖹ
࣭᳃ࠉఙ᫭
࣭ᯇ஭ဴ࣭
㣤ᒸ⥴⨾
࣭ᯘࠉᣅ㑻
࣭ᘪሙᚭ
࣭▼ᶫᗣᏊ
࣭໭⃝ⱱⰋ
࣭5RVHWWH0HUHVFRWWL
࣭<YHV*LQHVWH
࣭༓ཎᗣ⿱
࣭ᯇᮏ⣧ኵ
࣭⣽㇂ࠉㄔ
࣭ᾆᒸಇኵ
࣭ᒣ⃝୍ᶞ
࣭໭ᮧࠉ඘
࣭ᯘ┿⌮Ꮚ
࣭Ṋ⏣⣧୕
࣭⸨⏣㈗ஓ
࣭኱㏕ⱱⓏᙪ
࣭ᾆᒸಇኵ
࣭ຍ⸨ඖᙪ
࣭ෆᐊᬛஓ
࣭㧗ᯘࠉ㤾
࣭㛵ᒇఙᏊ
࣭ᮌᮧඃ௓
࣭ຊ୸ࠉ⿱
࣭ఀཎ⣲Ꮚ
࣭Ᏻ஭ᝋᏊ
࣭ධỤ㤶⤮-3236ⅆ㹼㔠࣭㛛㤿ࡢࡾᏊ㸦75,3᭶࣭ⅆ࣭ᮌ࣭㔠
࣭ྜྷᕝளᕼ᭶㹼㔠
࣭ቑ⏣▱ᐇ㸦᭶㹼㔠㸧
࣭ᮌᮧ⮳
࣭୰ᕝ㐍
࣭⸨ᒸṇே
࣭Ỉ㊊㑥㞝
࣭༡ಟྖ㑻
࣭ᮤ㜶
࣭ᚨ୸⿱
࣭Ⲩ஭⨾ᕼ
࣭⚄ᓮᬗ
࣭ዉ㡲ᜨ⨾Ꮚ
࣭୕ᾆṇ⛱
࣭ᆏᮏዲ᫛
࣭Ỉ㇂೺ே
࣭▼ᮏ᫴୍
࣭ఀ⸨᠇἞
࣭ୖ⩚⍠⨾
࣭ຍ⣡⁠
࣭⳥⏣࿘
࣭⇃⏣ᨻಙ
࣭⠛⏣ၨ
࣭㕥ᮌ⯟
࣭ⰼᅬඖ
࣭⸨Ἴⰾ
࣭ᕝᓥ⣲Ꮚ
࣭㇂஭ၨ୍
࣭⛅ᒣ㑥ᙪ
࣭኱ᓥஂ஧
࣭኱ఫᖾྖ
࣭ᑠᒣ⏣Ꮥ
࣭㛛ᯇࠉ㈼
࣭ᩧ⸨ྐ㑻
࣭᪂᳃ຍዉᏊ
࣭㧗ᶫṇᙪ
࣭㟷ᮌၨ௓
࣭ᩧ⸨ྐ㑻
࣭ຍᡃྩᏕ
࣭ෆᒣຮ
࣭ᴮᮏ༓ỤᏊ
࣭ᮌᮧ⨾࿴Ꮚ
࣭ቑ⏣Ẏ
࣭ᐑᓮ᪥ฟᾏ
࣭☾㒊㝧
࣭ᒣ⏣ᩄஅ
࣭すཎభ୍
࣭㏆⸨┤ᶞ
࣭㧗ᮌᜨ⨾
◊✲ဨ
࣭ྡ㒓┤ᶞ
࣭୰ᮧࠉ᠇
࣭すᒣࠉᚭ
࣭ᯇᓮ೺୍㑻
࣭ᯇᮧ┿ྖ
࣭㟷ᮌὈᏊ
࣭㛗㇂ᕝᨻᚨ
࣭ᒾ㷂ᫀᶞ
࣭ᵽཱྀ㡰ஓ
࣭ᆏ⏣ⱥ᫂
࣭᪂ṇ⏤⣖Ꮚ
࣭㐍⸨⨾ὠᏊ
࣭➉⭜ⱥᶞ
࣭୰ᮧ㞞Ꮚ
࣭ᯘ⿱ྐ
࣭ᮡᮏ┿ᶞ
࣭ᑠὠ඙୍㑻
࣭ụୖᖾ᠇
࣭➉ୗᬛᜨ
࣭✄ྜྷ⨾⏤⣖
࣭⸨ᕝ཭Ꮚ
࣭బࠎᮌ┿⌮Ꮚ
࣭୰ᮧዉὠᏊ
࣭ຍ⸨ᝆ
࣭⏣୰ᏹᶞ
࣭ᒣ⏣ᫀ࿴
࣭㔜Ᏻ༓ⰼ
⮫ᗋ◊✲ࢭࣥࢱ࣮⤌⧊ᅗ◊✲ဨ㸧
ࠉ
࣭㧗ᮧᬗᏊ㸦᭶ⅆᮌ㔠㸧
࣭ྜྷ⏣⨾Ụ㸦᭶࣭Ỉ㸧
࣭୕⎼ⱥᏊ㸦ⅆ࣭ᮌ㸧
࣭ୖⷵ┤Ꮚ㸦ⅆ࣭㔠㸧
࣭㛵ཱྀ㤶௦Ꮚ
ྡ㄃ࢭࣥࢱ࣮㛗┤ᒓ
୍ぴ㸼
⛎᭩
࣭ᯘඵ༓ᜨ㸦᭶࣭Ỉ࣭㔠㸧
࣭Ώ㎶㝧Ꮚ
࣭ྜྷ⏣ᬛ⨾㸦Ỉᮌ㔠㸧
࣭ᕝᮧ㞝୍
࣭୰ᒣ┿ኸ
㛵ཱྀ㤶௦Ꮚ᭶㹼㔠
࣭↷ᒣ㐟᭶ⅆᮌ㔠
࣭ᡞᮧᖾ௦ࠉ㸦᭶࣭ⅆ㸧
࣭⇃⏣ࡲࡾ㸦᭶࣭Ỉ㹼㔠㸧
࣭㧗⃝⨾⿱㸦᭶࣭ⅆ࣭Ỉ㸧
࣭㕥ᮌ᭸Ꮚࠉࠉ࣭∦ᒸᯞ㔛Ꮚ ࣭⊁ሙ㈗Ꮚ᭶㺃Ỉ㹼㔠
࣭ఀ㐩ዉ⨾࣭ᯘ┿ᕫᏊ
࣭ᗈᏳᩥᏊ࣭ᓥ㔝῟Ꮚ
࣭୰ᕝ⏤⨾ࠉࠉ࣭㔠ග❶Ụ
࣭ᮏஂ⨾Ꮚ
◊✲ຓᡭ
࣭⸨ᒸ⳯✑Ꮚ࣭Ⲩ∾⨾ᶞ
㻌
㻌
㻌
㻌
䊤㻌 ⥘㡿䚸つ⛬䛺䛹㻌
㻌
ᖹᡂ㸯㸴ᖺ㸲᭶㸯᪥つ⛬➨㸰㸷ྕ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮
⮫ᗋ◊✲ࢭࣥࢱ࣮㸦ឤぬჾࢭࣥࢱ࣮㸧タ⨨㐠Ⴀ⥘㡿
㸦タ⨨㸧
➨㸯᮲ ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮㸦௨ୗࠕᙜ㝔ࠖ࡜࠸࠺ࠋ㸧࡟⮫ᗋ◊
✲ࢭࣥࢱ࣮㸦ឤぬჾࢭࣥࢱ࣮㸧㸦௨ୗࠕឤぬჾࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ㸧ࢆ⨨ࡃࠋ
㸦┠ⓗ㸧
➨㸰᮲ ឤぬჾࢭࣥࢱ࣮ࡣࠊ⮫ᗋ㒊㛛࡜ᐦ᥋࡟㐃ᦠࢆ࡜ࡾ࡞ࡀࡽࠊឤぬჾ⑌ᝈ㸦║⛉ࠊ⪥
㰯⛉㸧ࡢ⮫ᗋ◊✲࡟୺యࢆ࠾ࡁࠊཎᅉ୙᫂ࡢ⑌ᝈࠊ࠶ࡿ࠸ࡣ἞⒪ࡢᅔ㞴࡞⑌ᝈࡢ⑓ᅉࡢ
ゎ᫂ࠊ἞⒪ἲࡢ㛤Ⓨ࡞࡝ࢆ⾜࠺ࡓࡵࠊෆእࡢ◊✲⪅࡟ᗈࡃ◊✲ࡢሙࢆ୚࠼ࠊ◊✲᪋タࡢ
ຠᯝⓗ࡞㐠⏝ࢆᅗࡾࡘࡘࠊࡉࡽ࡟ࠊᮏ㝔ࡢᢸ࠺ᨻ⟇་⒪ศ㔝㸦ࡀࢇࠊᚠ⎔ჾ⑌ᝈࠊ⭈⑌
ᝈࠊෆศἪ࣭௦ㅰ⑌ᝈࠊච␿␗ᖖ⑌ᝈࠊ⾑ᾮ㐀⾑ჾ⑌ᝈࠊᡂ⫱་⒪ࠊ⢭⚄⑌ᝈ➼㸧ࢆྵ
ࡵࡓᖜᗈ࠸⮫ᗋ◊✲ࢆ᥎㐍ࡍࡿࠋ
㸦⤌⧊㸧
➨㸱᮲ ឤぬჾࢭࣥࢱ࣮ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮㛗㸦௨ୗࠕࢭࣥࢱ࣮㛗ࠖ࡜࠸࠺ࠋ㸧ࠊ㒊㛗ࠊ
ᐊ㛗ࠊᐊဨཬࡧὶື◊✲ဨ࡛ᵓᡂࡍࡿࠋ
㸰 ࢭࣥࢱ࣮㛗ࡣࠊ⑓㝔㛗ࡢᣦ᥹┘╩ࡢࡶ࡜ࠊᡤᒓ⫋ဨࢆᣦ᥹ࡋࠊឤぬჾࢭࣥࢱ࣮ࡢᴗົ
ࢆ⤫ᣓࡍࡿࠋ
㸱 㒊㛗ࡣࠊࢭࣥࢱ࣮㛗ࡢᣦ᥹ࡢࡶ࡜ࠊᐊ㛗ࢆ┘╩ࡋ◊✲࡟ࡘ࠸࡚ຓゝᣦᑟࢆ⾜࠺ࠋ
㸲 ᐊ㛗ࡣࠊᐊဨཬࡧ◊✲ဨࢆᣦᑟ┘╩ࡋࠊᙜヱ◊✲ᐊࡢᴗົࢆ㐙⾜ࡍࡿࠋ
㸳 ឤぬჾࢭࣥࢱ࣮࡟ḟࡢ◊✲㒊ཬࡧᐊࢆ⨨ࡁࠊ㒊㛗ࠊᐊ㛗ࢆᐃࡵࡿࠋ
୍ ᨻ⟇་⒪௻⏬◊✲㒊
࢖ ⮫ᗋ␿Ꮫ◊✲ᐊ
ࣟ ་⒪⤒Ⴀ᝟ሗ◊✲ᐊ
ࣁ ᡭ⾡ᨭ᥼ࣟ࣎ࢵࢺᢏ⾡ᛂ⏝◊✲ᐊ
ࢽ ⮫ᗋ◊✲࣭἞㦂᥎㐍ᐊ
஧ どぬ◊✲㒊
࢖ どぬ⏕⌮Ꮫ◊✲ᐊ
ࣟ ║ගᏛ◊✲ᐊ
ࣁ ࣮ࣟࣅࢪࣙࣥ◊✲ᐊ
୕ ⫈ぬ࣭ᖹ⾮ぬ◊✲㒊
࢖ ⫈ぬ㞀ᐖ◊✲ᐊ
ࣟ ᖹ⾮ぬ㞀ᐖ◊✲ᐊ
ࣁ ෌⏕་⒪◊✲ᐊ
ᅄ ேᕤ⮚ჾ࣭ᶵჾ㛤Ⓨ◊✲㒊
࢖ ௦⏝⮚ჾ㛤Ⓨ◊✲ᐊ
ࣟ 㡢ኌ࣭ゝㄒࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥ◊✲ᐊ
ࣁ Ⓨ⏕་Ꮫ◊✲ᐊ
஬ ศᏊ⣽⬊⏕≀Ꮫ◊✲㒊
࢖ どぬ⏕≀Ꮫ◊✲ᐊ
ࣟ ⚄⤒⏕≀Ꮫ◊✲ᐊ
― 235 ―
㸦㐠Ⴀጤဨ఍㸧
➨㸲᮲ ឤぬჾࢭࣥࢱ࣮ࡢ෇⁥࡞㐠Ⴀࢆᅗࡿࡓࡵࠊ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭ
ࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮㸦ឤぬჾࢭࣥࢱ࣮㸧㐠Ⴀጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜࠸࠺ࠋ㸧ࢆ
⨨ࡃࠋ
㸰 ጤဨ఍ࡢጤဨ㛗ࡣ⑓㝔㛗࡜ࡋࠊጤဨࡣ๪㝔㛗ࠊࢭࣥࢱ࣮㛗ࠊྛࢭࣥࢱ࣮㒊㛗ࠊ஦ົ㒊
㛗ࠊ⟶⌮ㄢ㛗ࠊ௻⏬ㄢ㛗ཬࡧᴗົ⌜㛗࡜ࡍࡿࠋ
㸱 ጤဨ㛗ࡣᚲせ࡜ㄆࡵࡓ࡜ࡁࡣࠊ๓㡯࡟ᐃࡵࡿ⫋ဨࡢ௚࡟㛵ಀ⫋ဨࢆጤဨ఍࡟ฟᖍࡉࡏ
ពぢࢆồࡵࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸲 㐠Ⴀጤဨ఍ࡣᖺ㸰ᅇ㛤ദࡋࠊጤဨ㛗ࡀᚲせ࡜ㄆࡵࡓ࡜ࡁࡣࠊ⮫᫬࡟ጤဨ఍ࢆ㛤ദࡍࡿ
ࡇ࡜ࡀ࡛ࡁࡿࠋ
㸳 ጤဨ఍࡟࠾࠸࡚ḟࡢ஦㡯࡟ࡘ࠸࡚ᑂ㆟ࢆ⾜࠺ࠋ
୍ ឤぬჾࢭࣥࢱ࣮ࡢ⟶⌮㐠Ⴀ࡟㛵ࡍࡿࡇ࡜
஧ ឤぬჾࢭࣥࢱ࣮ࡢே஦⤒⌮࡟㛵ࡍࡿࡇ࡜
୕ ࡑࡢ௚
㸴 ጤဨ఍㆟஦ࡣࠊ඲࡚㆟஦㘓࡜ࡋ࡚ಖᏑࡍࡿࡶࡢ࡜ࡋࠊグ㘓ࡣᴗົ⌜㛗ࡀࡇࢀ࡟࠶ࡓࡿࠋ
㸦ឤぬჾࢭࣥࢱ࣮ᇶᮏᴗົ㸧
➨㸳᮲ ឤぬჾࢭࣥࢱ࣮ࡣࠊ⑓㝔㛗ࡢᣦ᥹┘╩ࡢࡶ࡜ࠊḟࡢᴗົࢆ㐙⾜ࡍࡿࡶࡢ࡜ࡍࡿࠋ
୍ ᙜ㝔ࡢ≉Ⰽࢆ⏕࠿ࡋࡓ⮫ᗋ◊✲ࢆᐇ᪋ࡍࡿࡇ࡜ࠋ
஧ ᨻ⟇་⒪ࢿࢵࢺ࣮࣡ࢡࢆ⏕࠿ࡋࡓ⮫ᗋ◊✲ࢆᐇ᪋ࡍࡿࡇ࡜ࠋ
୕ ◊✲㈝ࡢᇳ⾜࡟ࡘ࠸࡚ࡣࠊࢭࣥࢱ࣮㛗ࡀྛ㒊㛗࡜༠㆟ࡢ࠺࠼ᇳ⾜ィ⏬ࢆ⟇ᐃࡋࠊ⑓
㝔㛗ࡢᢎㄆࢆᚓ࡚ᇳ⾜ࡋࠊᖺᗘᮎ࡟ࡑࡢ఍ィሗ࿌ࢆ⾜࠺ࡇ࡜ࠋ
ᅄ ࢭࣥࢱ࣮௨እࡢ◊✲⪅࡜ࡶඹྠࡋ࡚⮫ᗋ◊✲ࢆ⾜࠸ࠊ◊✲ᡂᯝࢆᙜ㝔ࡢ⮫ᗋ࡟཯ᫎ
ࡉࡏࡿࡼ࠺ດࡵࡿࡇ࡜ࠋ
஬ ᆅᇦ་⒪㐃ᦠࢆᅗࡿ࠺࠼࠿ࡽࡶࠊᆅᇦ་⒪ᢏ⾡ࡢྥୖ࡟㈨ࡍࡿࡇ࡜ࠋ
භ ᐃᮇⓗ࡟⮫ᗋ◊✲᳨ウ఍ࠊⓎ⾲఍ࢆ㛤ദࡋࠊࡇࢀࢆබ㛤ࡍࡿࡇ࡜ࠋ
୐ ◊✲ᡂᯝࡣᏛ఍ࠊᏛ⾡㞧ㄅ࡞࡝ࢆ㏻ࡌ࡚ࠊᗈࡃබ⾲ࡍࡿࡇ࡜ࠋ
ඵ ឤぬჾ㛵㐃ࡢ᪂⸆㛤Ⓨࠊᶵჾ㛤Ⓨ࡟㛵ࢃࡿᇶ♏ⓗࠊ⮫ᗋⓗ἞㦂ࢆ✚ᴟⓗ࡟᥎㐍ࡍࡿ
ࡇ࡜ࠋ
஑ ࢭࣥࢱ࣮㛗ࡣࠊᙜヱᖺᗘ࡟࠾ࡅࡿ◊✲ィ⏬ࢆ㸲᭶ᮎ᪥ࡲ࡛ࠊ◊✲ሗ࿌ࢆ⩣ᖺࡢ㸳᭶
ᮎ᪥ࡲ࡛࡟సᡂࡍࡿࡇ࡜ࠋ
༑ ឤぬჾࢭࣥࢱ࣮ࢆ฼⏝ࡋ࡚⾜ࢃࢀࡓ඲࡚ࡢᴗ⦼ࡣࠊྛ㒊㛗ࡢ㈐௵࡟࠾࠸࡚ࠊᙜヱᖺ
ᗘᮎࡲ࡛࡟ࢭࣥࢱ࣮㛗࡟ሗ࿌ࡍࡿࡇ࡜ࠋ
༑୍ ➇தⓗ◊✲㈝㸦ᩥ㒊⛉Ꮫ┬◊✲㈝⿵ຓ㔠ࠊཌ⏕⛉Ꮫ◊✲㈝⿵ຓ㔠࡞࡝㸧➼ࡢ⤒⌮
஦ົࡣࠊ⑓㝔㛗࡟஦ົጤ௵ࡍࡿࡇ࡜ࠋ
㸦ឤぬჾࢭࣥࢱ࣮఍㆟㸧
➨㸴᮲ ឤぬჾࢭࣥࢱ࣮࡟◊✲ࡢຠ⋡໬ࢆࡣ࠿ࡿࡓࡵཬࡧឤぬჾࢭࣥࢱ࣮ෆࡢ㐃⤡ㄪᩚ
ࢆ⾜࠺ࡓࡵឤぬჾࢭࣥࢱ࣮఍㆟ࢆࡶ࠺ࡅࡿࠋ
㸰 ࢭࣥࢱ࣮఍㆟ࡣࢭࣥࢱ࣮㛗ࡀྊ㞟ࡋࠊྛ㒊㛗ࠊᐊ㛗ࠊ◊✲ဨ࡞࡝ᐇ㝿࡟◊✲ࢆ⾜ࡗ࡚
࠸ࡿ⪅ࡣཧຍࡍࡿࡇ࡜ࡀฟ᮶ࡿࠋ
㸱 ࢭࣥࢱ࣮఍㆟ࡣẖ᭶➨஧ᮌ᭙᪥࡟㛤ദࡍࡿࠋ
㸦ே஦ホ౯㸧
➨㸵᮲ ࢭࣥࢱ࣮◊✲⫋ဨࡣࠊࢭࣥࢱ࣮㛗ࢆྵࡵࠊ௵ᮇࢆ㸱ᖺ࡜ࡋࠊ㸱ᖺ㛫ࡢᴗ⦼ࢆホ౯ࠊ
― 236 ―
຺᱌ࡋࠊࡑࡢ⫋఩ࢆ⥅⥆ࡍࡿࡇ࡜ࡀฟ᮶ࡿࠋ
㸰 ホ౯ࡢࡓࡵࡢឤぬჾࢭࣥࢱ࣮ホ౯ጤဨ఍ࢆタࡅࡿࠋ
㸦ホ౯ጤဨ఍㸧
➨㸶᮲ ホ౯ጤဨ఍ࡣ⑓㝔㛗ࡀྊ㞟ࡋࠊᵓᡂጤဨࡣ⑓㝔㛗ࠊ๪㝔㛗ࠊࢭࣥࢱ࣮㛗࡜ࡋࠊཎ
๎࡜ࡋ࡚ࠊ㝔እ࠿ࡽⱝᖸྡࡢ᭷㆑⪅㸦እ㒊ጤဨ㸧ࡢཧຍࢆせㄳࡍࡿࠋ
㸰 ホ౯ጤဨ఍ࡣࠊឤぬჾࢭࣥࢱ࣮ࡢάືཬࡧ◊✲ဨࡢᴗ⦼ࢆ㸯ᖺࡈ࡜࡟ホ౯ࡋࠊ㐠Ⴀጤ
ဨ఍࡟ሗ࿌ࡍࡿࠋ
➨㸷᮲ ࡇࡢ⥘㡿࡟ᐃࡵࡿࡶࡢࡢ௚ࠊឤぬჾࢭࣥࢱ࣮࡟㛵ࡋ࡚ᚲせ࡞஦㡯࡟ࡘ࠸࡚ࡣࠊ㐠
Ⴀጤဨ఍࡟࠾࠸࡚ᑂ㆟Ỵᐃࡍࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢ⥘㡿ࡣࠊᖹᡂ㸯㸴ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ࡞࠾ࠊᖹᡂ㸯㸳ᖺ㸯㸮᭶㸯᪥࠿ࡽ᪋⾜
ࡋ࡚࠸ࡿ⥘㡿ࡣᗫṆࡍࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢ⥘㡿ࡣࠊᖹᡂ㸰㸲ᖺ㸶᭶㸯᪥࠿ࡽ୍㒊ᨵᐃࡋ࡚᪋⾜ࡍࡿࠋ
㝃 ๎㸦➨㸱᮲➨㸳㡯➨㸯ྕ㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢ⥘㡿ࡣࠊᖹᡂ㸰㸳ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
― 237 ―
ᖹᡂ㸯㸴ᖺ㸲᭶㸯᪥つ⛬➨㸶㸵ྕ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮
⮫ᗋ◊✲ࢭࣥࢱ࣮⛉Ꮫ◊✲㈝⿵ຓ㔠࡟ࡼࡿ◊✲ᐇ᪋つ⛬
㸦タ⨨㸧
➨㸯᮲ ࡇࡢつ⛬ࡣࠊ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮㸦௨ୗࠕᙜ㝔ࠖ࡜࠸࠺ࠋ
㸧
⮫ᗋ◊✲ࢭࣥࢱ࣮ࡢ◊✲⪅ࡀ⾜࠺◊✲ࡢ࠺ࡕࠊ⛉Ꮫ◊✲⿵ຓ㔠࡟ࡼࡿ◊✲ࡢᡂᯝࢆ࠶ࡆ
ࡿ࡜࡜ࡶ࡟◊✲ᡂᯝࡢᬑཬࢆᅗࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
㸦◊✲ィ⏬ࡢ⟇ᐃ㸧
➨㸰᮲ ◊✲⪅ࡣࠊ⛉Ꮫ◊✲㈝⿵ຓ㔠࡟ࡼࡿ◊✲ࢆ⾜࠺ሙྜࡣࠊ௚ࡢᴗົ࡟ᨭ㞀ࢆཬࡰࡉ
࡞࠸⠊ᅖ࡟࠾࠸࡚⮬Ⓨⓗ࡟◊✲ィ⏬ࢆ❧᱌ࡋࠊᐇ᪋ࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸰 ◊✲⪅ࡣࠊ࠶ࡽ࠿ࡌࡵᵝᘧ࡟ᚑࡗࡓ◊✲ィ⏬᭩ࢆసᡂࡋࠊᙜヱㄪ᭩ࡢ෗ࡋࢆᙜ㝔⑓㝔
㛗ᐄ࡟ᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦◊✲ᡂᯝࡢྲྀᢅ㸧
➨㸱᮲ ◊✲⪅ࡣࠊ๓᮲࡟ࡼࡾ⛉Ꮫ◊✲㈝⿵ຓ㔠࡟ࡼࡾ⾜ࡗࡓ◊✲࡟ࡘ࠸࡚ࡣࠊ௚ࡢつ⛬
࡟ಀࢃࡽࡎࠊᙜヱ◊✲ࡢ◊✲ᡂᯝ࡟ࡘ࠸࡚⮬ࡽࡢุ᩿࡛බ⾲ࡍࡿࡇ࡜ࡀฟ᮶ࡿࠋࡲࡓࠊ
බ⾲࡟࠶ࡓࡗ࡚ࡣࠊ⫋ົ࡜ࡋ࡚⮬Ⓨⓗ࡟Ꮫ఍➼࡟ཧຍ࡛ࡁࡿࡶࡢ࡜ࡍࡿࠋ
㸦◊✲ሗ࿌ࡢ⩏ົ㸧
➨㸲᮲ ◊✲⪅ࡣࠊᙜヱไᗘ࡟ಀࢃࡿつ⛬㢮࡟ᚑ࠸ሗ࿌᭩ࢆసᡂࡋࠊᙜヱሗ࿌᭩➼ࡢ෗ࡋ
ࢆᙜ㝔⑓㝔㛗ᐄ࡟ᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦⟶⌮➼ࡢ஦ົ㸧
➨㸳᮲ ⛉Ꮫ◊✲㈝⿵ຓ㔠ࡢ⟶⌮➼ࡢ஦ົࡣࠊ௻⏬ㄢࡀᡤᤸࡍࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸯㸴ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ࡞࠾ࠊᖹᡂ㸯㸳ᖺ㸯㸮᭶㸯᪥࠿ࡽ᪋⾜
ࡋ࡚࠸ࡿ᪤Ꮡࡢつ⛬ࡣᗫṆࡍࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸲ᖺ㸶᭶㸯᪥࠿ࡽ୍㒊ᨵᐃࡋ࡚᪋⾜ࡍࡿࠋ
― 238 ―
ᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥つ⛬➨㸴㸮ྕ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮㑇ఏᏊ⤌᥮࠼ᐇ㦂Ᏻ඲⟶⌮つ⛬
➨㸯᮲ ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮
㸦ឤぬჾࢭࣥࢱ࣮㸧
㸦௨ୗࠕᮏࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ
㸧࡟࠾ࡅࡿ㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡢ㐺ṇ࡞ᐇ᪋࡟㛵ࡋ࡚ࡣࠊ⏕
≀ࡢከᵝᛶ࡟㛵ࡍࡿ᮲⣙ࡢࣂ࢖࢜ࢭ࣮ࣇࢸ࢕࡟㛵ࡍࡿ࢝ࣝࢱ࣊ࢼ㆟ᐃ᭩ࠊ㑇ఏᏊ⤌⤌᥮
࠼⏕≀➼ࡢ౑⏝➼ࡢつไ࡟ࡼࡿ⏕≀ࡢከᵝᛶࡢ☜ಖ࡟㛵ࡍࡿἲᚊ㸦ᖹᡂ㸯㸳ᖺἲᚊ➨㸷
㸵ྕ㸧
ࠊ
◊✲㛤Ⓨ➼࡟ಀࡿ㑇ఏᏊ⤌᥮࠼⏕≀➼ࡢ➨஧✀౑⏝➼࡟ᙜࡓࡗ࡚ᇳࡿ࡭ࡁᣑᩓ㜵
Ṇᥐ⨨➼ࢆᐃࡵࡿ┬௧㸦ᖹᡂ㸯㸴ᖺᩥ㒊⛉Ꮫ┬࣭⎔ቃ┬௧➨㸯ྕ㸧
ࠊ◊✲㛤Ⓨẁ㝵࡟࠾ࡅ
ࡿ㑇ఏᏊ⤌᥮࠼⏕≀➼ࡢ➨஧✀౑⏝➼ࡢᡭᘬࡁ㸦ᖹᡂ㸰㸱ᖺ㸳᭶ᩥ㒊⛉Ꮫ┬◊✲᣺⯆ᒁ
ࣛ࢖ࣇࢧ࢖࢚ࣥࢫㄢ ⏕࿨೔⌮࣭Ᏻ඲ᑐ⟇ᐊ㸧
ࠊᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮㑇ఏ
Ꮚ⤌᥮࠼⏕≀➼ᐇ㦂ᣦ㔪࡟ᇶ࡙ࡁᐃࡵࡽࢀࡿࡶࡢࢆ㑂Ᏺࡍࡿࠋ
➨㸰᮲ ᮏࢭࣥࢱ࣮࡟࠾ࡅࡿ㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡢ㐺ṇ࡞ᐇ᪋࡟㛵ࡋ࡚ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ
࣮㛗㸦௨ୗࠕࢭࣥࢱ࣮㛗ࠖ࡜࠸࠺ࠋ㸧ࡀ⥲ᣓ⟶⌮ࡍࡿࠋ
➨㸱᮲ 㑇ఏᏊ⤌᥮࠼ᐇ㦂ࢆ㐺ṇ࡟ᐇ᪋ࡍࡿࡓࡵࠊᮏࢭࣥࢱ࣮࡟㑇ఏᏊ⤌᥮࠼ᐇ㦂Ᏻ඲ጤ
ဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜࠸࠺ࠋ㸧ࢆ⨨ࡃࠋ
➨㸲᮲ ጤဨ఍ࡣࠊู࡟ᐃࡵࡿ㑇ఏᏊ⤌᥮࠼ᐇ㦂ィ⏬᭩ࢆࠊᐇ㦂⪅࠿ࡽ⏦ㄳࡀ࠶ࡗࡓ࡜ࡁ
࡟ᑂᰝࡋࠊᢎㄆཪࡣ୙ᢎㄆࢆỴᐃࡍࡿࠋ
㸰 ጤဨ఍ࡣࠊᢎㄆࡋࡓ㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡢ◊✲ィ⏬ࡀἲ௧࡟㐪཯ࡋ࡚࠸ࡿ࡜ࡳ࡜ࡵࡽࢀ
ࡿ࡜ࡁཪࡣᙜヱ◊✲ࡀィ⏬࡟ᚑࡗ࡚㐺ṇ࡟ᐇ᪋ࡉࢀ࡚࠸࡞࠸࡜ㄆࡵࡽࢀࡿ࡜ࡁࡣࠊᚲせ
࡞ᥐ⨨࡟ࡘ࠸࡚ᣦᑟࠊຓゝࡋࠊሙྜ࡟ࡼࡗ࡚ࡣࡇࢀࢆ୰Ṇࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
➨㸳᮲ ጤဨ఍ࡣࠊḟࡢྛྕ࡟ᥖࡆࡿጤဨ࡛⤌⧊ࡍࡿࠋ
୍ ᐇ㦂ື≀ࢆྲྀࡾᢅ࠺◊✲㒊㒊㛗࠶ࡿ࠸ࡣ◊✲ᐊᐊ㛗 㸰ྡ
஧ ࡑࡢ௚ࢭࣥࢱ࣮㛗ࡀᚲせ࡜ㄆࡵࡿ⪅ ⱝᖸྡ
㸰 ጤဨ఍ࡢጤဨ㛗ࡣࢭࣥࢱ࣮㛗ࢆ௨࡚඘࡚ࠊጤဨࡣࢭࣥࢱ࣮㛗ࡀጤკࡍࡿࠋ
࡞࠾ࠊࢭࣥࢱ࣮㛗୙ᅾࡢሙྜࡣ㝔㛗ࡀጤဨ㛗ࢆᣦྡࡍࡿࡶࡢ࡜ࡍࡿࠋ
➨㸴᮲ ◊✲ィ⏬ࡢ㐺ṇ࡞ᐇ᪋࡟㝿ࡋ࡚ࡣࠊࡑࡢ㈐௵ࡣ◊✲㒊㒊㛗ࡲࡓࡣ◊✲ᐊᐊ㛗㸦௨
ୗࠕᐇ㦂⟶⌮⪅ࠖ࡜࠸࠺ࠋ㸧ࡀ㈇࠺ࡶࡢ࡜ࡍࡿࠋ
➨㸵᮲ 㑇ఏᏊ⤌᥮࠼ᐇ㦂ࢆᐇ᪋ࡋࡼ࠺࡜ࡍࡿ⪅ࡣࠊᮏࢭࣥࢱ࣮ࡢ◊✲ᐊ࡟ᡤᒓࡋ࡞ࡅࢀ
ࡤ࡞ࡽ࡞࠸ࠋ
㸰 ᐇ㦂⟶⌮⪅ࡣࠊ◊✲ィ⏬ࡢ❧᱌ཬࡧᐇ᪋࡟㝿ࡋ࡚ࡣࠊἲ௧ཬࡧࡇࡢつ⛬ࢆ㑂Ᏺࡋࠊ㑇
ఏᏊ⤌᥮࠼ᐇ㦂ࡢ㐺ṇ࡞⟶⌮࡟࠶ࡓࡿࡶࡢ࡜ࡍࡿࠋ
➨㸶᮲ 㑇ఏᏊ⤌᥮࠼ᐇ㦂ࢆᐇ᪋ࡋࡼ࠺࡜ࡍࡿሙྜ࡟ࡣࠊᐇ㦂⟶⌮⪅ࡣᡤᐃࡢᐇ㦂ィ⏬᭩
ࢆጤဨ఍࡟ᥦฟࡋ࡚ࠊᢎㄆࢆཷࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋᢎㄆࢆཷࡅࡓ◊✲ィ⏬ࢆኚ᭦ࡋࡼ
࠺࡜ࡍࡿሙྜࡶྠᵝ࡜ࡍࡿࠋ
㸰 ᐇ㦂⟶⌮⪅ࡣࠊ◊✲ࡢᐇ᪋࡟ᙜࡓࡗ࡚ண᝿ࡉࢀࡿ༴㝤ᛶ࡜ࡑࡢᑐᛂ᪉ἲ࡟ࡘ࠸࡚ᐇ㦂
ィ⏬᭩࡟᫂☜࡟グ㍕ࡍࡿࠋ
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㸱 ᐇ㦂ィ⏬᭩ࡀᥦฟࡉࢀࡓሙྜࠊጤဨ఍ࡣ᳨ウ఍㆟ࢆ㛤࠸࡚ᐇ㦂ࡢᢎㄆࡢ᭷↓ࢆỴᐃࡍ
ࡿࠋ
㸲 ጤဨ఍ࡣࠊᢎㄆࡋࡓ◊✲ィ⏬ࢆࢭࣥࢱ࣮㛗࡟ሗ࿌ࡋࠊᐇ㦂⟶⌮⪅࡟㏻▱ࡍࡿࠋ
➨㸷᮲ ᐇ㦂⟶⌮⪅ࡣࠊ㑇ఏᏊ⤌᥮࠼ᐇ㦂ࡢᐇ᪋≧ἣ࡟ࡘ࠸࡚ࠊᐇ㦂ィ⏬᭩࡟࠾ࡅࡿ◊✲
⤊஢᫬ཬࡧጤဨ఍࡞࡝ࡢồࡵ࡟ᛂࡌ࡚ࠊጤဨ఍࡟ᩥ᭩࡛ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸯㸮᮲ ࢭࣥࢱ࣮㛗ࡣࠊᢎㄆࡋࡓ◊✲ィ⏬࡟㐪཯ࡋ࡚⾜࡞ࢃࢀ࡚࠸ࡿ࡜ㄆࡵࡓሙྜࡲࡓ
ࡣጤဨ఍ࡀ◊✲ࡢኚ᭦ⱝࡋࡃࡣ୰Ṇࡢ່࿌ࢆ⾜࡞ࡗࡓሙྜ࡟ࡣࠊᐇ㦂⟶⌮⪅࡟ኚ᭦ཪࡣ
୰Ṇࢆ࿨ࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸯㸯᮲ ᐇ㦂⟶⌮⪅ࡣࠊᐇ㦂ࡢᐇ᪋࡟ᙜࡓࡾᐇ᪋⪅࠾ࡼࡧ࿘㎶᪋タ࡟ᑐࡍࡿᏳ඲☜ಖࠊ
බ⾗⾨⏕ࠊ࠾ࡼࡧ⏕ែ⣔ಖ඲ୖࡢᨭ㞀ࢆ㜵Ṇࡍࡿࡓࡵ࡟ᚲせ࡞ᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ
࡞࠸ࠋ
㸰 ᐇ㦂⟶⌮⪅ࡣࠊ㑇ఏᏊ⤌᥮࠼⏕≀➼ࢆ⟶⌮༊ᇦ࡟ᑒࡌ㎸ࡵࡿࡼ࠺ࠊᚲせ࡞ᣑᩓ㜵Ṇ⿦
⨨ࢆᇳࡽ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱 ⅏ᐖࡑࡢ௚ࡢ஦ᨾ࡟ࡼࡾࠊ⤌᥮࠼㑇ఏᏊ࡟ࡼࡿởᰁࡶࡋࡃࡣ༊ᇦእ࡬ࡢ㐓㉮ࡀⓎ⏕ࡋࠊ
ࡲࡓࡣⓎ⏕ࡍࡿᜍࢀࡢ࠶ࡿ஦ែࢆⓎぢࡋࡓ⪅ࡣࠊ┤ࡕ࡟㐺ษ࡞ᥐ⨨ࢆ࡜ࡿ࡜࡜ࡶ࡟ࠊ㏿
ࡸ࠿࡟ᙜヱᐇ㦂⟶⌮⪅࠾ࡼࡧࢭࣥࢱ࣮㛗࡟㏻ሗࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸲 ᐇ㦂⟶⌮⪅ཬࡧࢭࣥࢱ࣮㛗ࡣࠊ┦஫࡟㐃⤡ࡋࠊᛂᛴࡢᥐ⨨ࢆㅮࡎࡿ࡜ඹ࡟ࠊ㝔㛗ࠊᅜ
❧⑓㝔ᶵᵓᮏ㒊ࠊ
ᩥ㒊⛉Ꮫ┬◊✲᣺⯆ᒁࣛ࢖ࣇࢧ࢖࢚ࣥࢫㄢ࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸯㸰᮲ ᐇ㦂ᐇ᪋⪅ࡣࠊ
ᙜヱᐇ㦂࡟ಀࡿෆᐜࢆグ㘓ࡋࠊ
ࡇࢀࢆಖᏑࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ᐇ㦂ᐇ᪋⪅ࡣࠊ㑇ఏᏊ⤌᥮࠼ື≀ࡢ㣫⫱࡟ᙜࡓࡗ࡚ࡣࠊ㣫⫱ື≀ࡢ඲ᩘࢆ௘యࡶྵࡵ
࡚ẖ㐌ィ ࡋࠊ㣫⫱ᩘ⟶⌮⡙࡟グ㘓ࡋ࡚ࠊᐇ㦂⟶⌮⪅࡟ሗ࿌ࡍࡿࠋ
㸱 ᐇ㦂ᐇ᪋⪅ࡣࠊ㑇ఏᏊ⤌᥮࠼⏕≀➼ࡢ⟶⌮༊ᇦ࡟࠾࠸࡚ࡣධ㏥ฟ᫬࡟⟶⌮⡙࡟グ㍕ࡍ
ࡿࠋ
㸲 㣫⫱ᩘ⟶⌮⡙ཬࡧධ㏥ฟ⟶⌮⡙ࡣࠊື≀ᐇ㦂ጤဨ఍୪ࡧ࡟ጤဨ఍࡟ᐃᮇⓗ࡟ᥦฟࡋࠊ
ᑂᰝ࣭ᢎㄆࢆ࠺ࡅࡿࠋ
➨㸯㸱᮲ 㝔㛗ࡣࠊᖺ࡟㸯ᅇ⛬ᗘࠊᐇ㦂ᐇ᪋⪅୪ࡧ࡟ᐇ㦂⟶⌮⪅࡟ᑐࡋ࡚ࠊ㑇ఏᏊ⤌᥮࠼
ᐇ㦂࡟㛵ࡍࡿἲ௧ࠊసᴗ⟶⌮ࠊ⤌᥮࠼㑇ఏᏊᣑᩓ㜵Ṇᥐ⨨ࠊ⥭ᛴ᫬ࡢᑐᛂ࡞࡝࡟ࡘ࠸࡚
ᩍ⫱カ⦎ࢆ⾜࠺ࠋ
㸰 ጤဨ఍ࡣࠊ౑⏝᪋タ࡟ࡘ࠸࡚ᖺ㸯ᅇ⤌᥮࠼㑇ఏᏊᣑᩓ㜵Ṇᥐ⨨ࢳ࢙ࢵࢡࣜࢫࢺ࡟ࡼࡿ
⮬ᕫⅬ᳨ࢆᐇ᪋ࡋࠊࡇࢀࢆᅜ❧⑓㝔ᶵᵓᮏ㒊⥲ྜ◊✲ࢭࣥࢱ࣮࡬ᥦฟࡍࡿࠋ
➨㸯㸲᮲ ࡇࡢつ⛬࡟ᐃࡵࡿࡶࡢࡢ࡯࠿ࠊࡑࡢ௚ᚲせ࡞஦㡯ࡣࠊጤဨ఍ࡀᐃࡵࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
㝃 ๎㸦➨㸳᮲➨㸰㡯㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸳ᖺ㸷᭶㸷᪥࠿ࡽ᪋⾜ࡍࡿࠋ
― 240 ―
㝃 ๎㸦➨㸳᮲➨㸰㡯㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸵ᖺ㸴᭶㸯㸳᪥࠿ࡽ᪋⾜ࡍࡿࠋ
― 241 ―
ᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥つ⛬➨㸴㸯ྕ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ື≀ᐇ㦂⟶⌮つ⛬
┠ḟ
➨㸯❶ ⥲๎㸦➨㸯᮲㸫➨㸲᮲㸧
➨㸰❶ ື≀ᐇ㦂ጤဨ఍㸦➨㸳᮲㸫➨㸯㸱᮲㸧
➨㸱❶ ື≀ᐇ㦂➼ࡢᐇ᪋㸦➨㸯㸲᮲㸫➨㸯㸵᮲㸧
➨㸲❶ ᪋タ➼㸦➨㸯㸶᮲㸫➨㸰㸱᮲㸧
➨㸳❶ ᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶㸦➨㸰㸲᮲㸫➨㸱㸰᮲㸧
➨㸴❶ Ᏻ඲⟶⌮㸦➨㸱㸱᮲㸫➨㸱㸲᮲㸧
➨㸵❶ ᩍ⫱カ⦎㸦➨㸱㸳᮲㸧
➨㸶❶ ⮬ᕫⅬ᳨࣭ホ౯ཬࡧ᳨ド㸦➨㸱㸴᮲㸧
➨㸷❶ ᝟ሗබ⾲㸦➨㸱㸵᮲㸧
➨㸯㸮❶ 㞧๎㸦➨㸱㸶᮲㸫➨㸱㸷᮲㸧
㝃 ๎
➨㸯❶ ⥲๎
㸦㊃᪨㸧
➨㸯᮲ ࡇࡢつ⛬ࡣࠊ◊✲ᶵ㛵➼࡟࠾ࡅࡿື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿᇶᮏᣦ㔪㸦ᖹᡂ㸯㸶
ᖺᩥ㒊⛉Ꮫ┬࿌♧➨㸵㸯ྕࠋ௨ୗࠕᩥ⛉┬ᇶᮏᣦ㔪ࠖ࡜࠸࠺ࠋ㸧➨㸰᮲ࡢồࡵࡿᶵ㛵ෆ
つ⛬࡜ࡋ࡚ࠊ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮㸦௨ୗࠕࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ㸧
࡟࠾ࡅࡿື≀ᐇ㦂➼࡟㛵ࡋࠊᚲせ࡞஦㡯ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦ᇶᮏཎ๎㸧
➨㸰᮲ ᙜࢭࣥࢱ࣮࡟࠾ࡅࡿື≀ᐇ㦂➼࡟ࡘ࠸࡚ࡣࠊື≀ࡢឡㆤཬࡧ⟶⌮࡟㛵ࡍࡿἲᚊ㸦᫛
࿴㸲㸶ᖺἲᚊ➨㸯㸮㸳ྕࠋ௨ୗࠕἲࠖ࡜࠸࠺ࠋ㸧ࠊᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶୪ࡧ࡟ⱞ③
ࡢ㍍ῶ࡟㛵ࡍࡿᇶ‽㸦ᖹᡂ㸯㸶ᖺ⎔ቃ┬࿌♧➨㸶㸶ྕࠋ௨ୗࠕ㣫㣴ಖ⟶ᇶ‽ࠖ࡜࠸࠺ࠋ㸧ࠊ
ᩥ⛉┬ᇶᮏᣦ㔪ࠊື≀ᐇ㦂ࡢ㐺ṇ࡞ᐇ᪋࡟ྥࡅࡓ࢞࢖ࢻࣛ࢖ࣥ㸦᪥ᮏᏛ⾡఍㆟ᖹᡂ㸯㸶
ᖺ㸴᭶㸯᪥ࠋ௨ୗࠕ࢞࢖ࢻࣛ࢖ࣥࠖ࡜࠸࠺ࠋ㸧ࠊື≀ࡢฎศ᪉ἲ࡟㛵ࡍࡿᣦ㔪㸦ᖹᡂ㸵
ᖺ⥲⌮ᗓ࿌♧➨㸲㸮ྕ㸧ࡑࡢ௚ࡢἲ௧➼࡟ᐃࡵࡀ࠶ࡿࡶࡢࡢ࡯࠿ࠊࡇࡢつ⛬ࡢᐃࡵࡿ࡜
ࡇࢁ࡟ࡼࡿࠋ
㸰 ኱Ꮫ➼࡟࠾ࡅࡿື≀ᐇ㦂➼ࢆక࠺⏕࿨⛉Ꮫ◊✲ࡣࠊேࡢ೺ᗣ࣭⚟♴࣭ඛ➃་⒪ࡢ㛤Ⓨ
ᒎ㛤ࡢࡳ࡞ࡽࡎື≀ࡢ೺ᗣቑ㐍➼࡟࠾ࡅࡿ◊✲ศ㔝ࡢ㐍ᒎ࡟࠾࠸࡚ࡶᚲせ࡞ᡭẁ࡛࠶ࡿ
ࡇ࡜࠿ࡽࠊື≀ᐇ㦂➼ࡢᐇ᪋࡟ᙜࡓࡗ࡚ࡣࠊἲཬࡧ㣫㣴ಖ⟶ᇶ‽࡟༶ࡋࠊື≀ᐇ㦂➼ࡢ
ཎ๎࡛࠶ࡿ௦᭰ἲࡢ฼⏝㸦⛉Ꮫୖࡢ฼⏝ࡢ┠ⓗࢆ㐩ࡍࡿࡇ࡜ࡀ࡛ࡁࡿ⠊ᅖ࡟࠾࠸࡚ࠊ࡛
ࡁࡿ㝈ࡾື≀ࢆ౪ࡍࡿ᪉ἲ࡟௦ࢃࡾᚓࡿࡶࡢࢆ฼⏝ࡍࡿࡇ࡜ࢆ࠸࠺ࠋ㸧ࠊ౑⏝ᩘࡢ๐ῶ
㸦⛉Ꮫୖࡢ฼⏝ࡢ┠ⓗࢆ㐩ࡍࡿࡇ࡜ࡀ࡛ࡁࡿ⠊ᅖ࡟࠾࠸࡚ࠊ࡛ࡁࡿ㝈ࡾࡑࡢ฼⏝࡟౪ࡉ
ࢀࡿື≀ࡢᩘࢆᑡ࡞ࡃࡍࡿࡇ࡜➼࡟ࡼࡾᐇ㦂ື≀ࢆ㐺ษ࡟฼⏝ࡍࡿࡇ࡜࡟㓄៖ࡍࡿࡇ࡜
ࢆ࠸࠺ࠋ㸧ཬࡧⱞ③ࡢ㍍ῶ㸦⛉Ꮫୖࡢ฼⏝࡟ᚲせ࡞㝈ᗘ࡟࠾࠸࡚ࠊ࡛ࡁࡿ㝈ࡾື≀࡟ⱞ
③ࢆ୚࠼࡞࠸᪉ἲ࡟ࡼࡗ࡚ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࡇ࡜ࢆ࠸࠺ࠋ㸧ࡢ㸱㹐㸦5HSODFHPHQW㸦௦
᭰ἲࡢ฼⏝㸧ࠊ5HGXFWLRQ㸦ື≀฼⏝ᩘࡢ๐ῶ㸧ࠊ5HILQHPHQW㸦ⱞ③ࡢ㍍ῶ㸧㸧࡟ᇶ࡙ࡁࠊ
㐺ṇ࡟ᐇ᪋ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
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㸦ᐃ⩏㸧
➨㸱᮲ ࡇࡢつ⛬࡟࠾࠸࡚ࠊḟࡢྛྕ࡟ᥖࡆࡿ⏝ㄒࡢព⩏ࡣࠊࡑࢀࡒࢀᙜヱྛྕ࡟ᐃࡵࡿ
࡜ࡇࢁ࡟ࡼࡿࠋ
୍ ື≀ᐇ㦂➼
ᐇ㦂ື≀ࢆᩍ⫱ࠊヨ㦂◊✲ཪࡣ⏕≀Ꮫⓗ〇๣ࡢ〇㐀ࡢ⏝ࡑࡢ௚ࡢ⛉Ꮫୖࡢ฼⏝࡟౪
ࡍࡿࡇ࡜ࢆ࠸࠺ࠋ
஧ 㣫㣴ಖ⟶᪋タ
ᐇ㦂ື≀ࢆᜏᖖⓗ࡟㣫㣴ⱝࡋࡃࡣಖ⟶ཪࡣື≀ᐇ㦂➼ࢆ⾜࠺᪋タ࣭タഛࢆ࠸࠺ࠋ
୕ ᐇ㦂ᐊ
ᐇ㦂ື≀࡟ᐇ㦂᧯స㸦㸲㸶᫬㛫௨ෆࡢ୍᫬ⓗ࡞ಖ⟶ࢆྵࡴࠋ㸧ࢆ⾜࠺ື≀ᐇ㦂ᐊࢆ
࠸࠺ࠋ
ᅄ ᪋タ➼
㣫㣴ಖ⟶᪋タཬࡧᐇ㦂ᐊࢆ࠸࠺ࠋ
஬ ᐇ㦂ື≀
ື≀ᐇ㦂➼ࡢ฼⏝࡟౪ࡍࡿࡓࡵࠊ᪋タ➼࡛㣫㣴ཪࡣಖ⟶ࡋ࡚࠸ࡿ့ங㢮ࠊ㫽㢮ཪࡣ
∐⹸㢮➼࡟ᒓࡍࡿື≀㸦᪋タ➼࡟ᑟධࡍࡿࡓࡵ࡟㍺㏦୰ࡢࡶࡢࢆྵࡴࠋ㸧ࢆ࠸࠺ࠋ
භ ື≀ᐇ㦂ィ⏬
ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿィ⏬ࢆ࠸࠺ࠋ
୐ ື≀ᐇ㦂ᐇ᪋⪅
ື≀ᐇ㦂➼ࢆᐇ᪋ࡍࡿ⪅ࢆ࠸࠺ࠋ
ඵ ື≀ᐇ㦂㈐௵⪅
ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿᴗົࢆ⤫ᣓࡍࡿ⪅ࢆ࠸࠺ࠋ㸦⮫ᗋ◊✲ࢭࣥࢱ࣮㛗㸧
஑ ⟶⌮⪅
㝔㛗ࢆ࠸࠺ࠋ
༑ ᐇ㦂ື≀⟶⌮⪅
ᐇ㦂ື≀࡟㛵ࡍࡿ▱㆑ཬࡧ⤒㦂ࢆ᭷ࡍࡿ⪅࡛ࠊ⟶⌮⪅ࢆ⿵బࡋࠊᐇ㦂ື≀ࡢ⟶⌮ࢆ
ᢸᙜࡍࡿ⪅ࢆ࠸࠺ࠋ㸦◊✲㒊㛗࠶ࡿ࠸ࡣ◊✲ᐊ㛗࠾ࡼࡧጤဨ఍ࡀㄆࡵࡓ⪅㸧
༑୍ 㣫㣴⪅
ᐇ㦂ື≀⟶⌮⪅ཪࡣື≀ᐇ㦂ᐇ᪋⪅ࡢୗ࡛ᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶࡟ᚑ஦ࡍࡿ⪅ࢆ
࠸࠺ࠋ
༑஧ ⟶⌮⪅➼
⟶⌮⪅ࠊື≀ᐇ㦂㈐௵⪅ࠊᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࢆ࠸࠺ࠋ
༑୕ ᣦ㔪➼
ື≀ᐇ㦂➼࡟㛵ࡋ࡚ྛ⾜ᨻᶵ㛵ࡢᐃࡵࡿᇶᮏᣦ㔪ཬࡧ࢞࢖ࢻࣛ࢖ࣥࢆ࠸࠺ࠋ
㸰 ๓㡯➨㸶ྕ࡛つᐃࡍࡿື≀ᐇ㦂㈐௵⪅ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮㛗ࢆ௨࡚඘࡚ࡿࡀࠊ⮫ᗋ
◊✲ࢭࣥࢱ࣮㛗୙ᅾ࡟ࡼࡾࢭࣥࢱ࣮㝔㛗ࡀ஦ົྲྀᢅ࡜࡞ࡗ࡚࠸ࡿሙྜ࡟㝈ࡾࠊ⟶⌮⪅ࡣ
⮫ᗋ◊✲ࢭࣥࢱ࣮࡟ᡤᒓࡍࡿ㒊㛗⫋ࡢ୰࠿ࡽື≀ᐇ㦂㈐௵⪅ࢆᣦྡࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦㐺⏝⠊ᅖ㸧
➨㸲᮲ ࡇࡢつ⛬ࡣࠊᙜࢭࣥࢱ࣮࡟࠾࠸࡚ᐇ᪋ࡉࢀࡿ့ங㢮ࠊ㫽㢮ཪࡣ∐⹸㢮➼ࡢ⏕యࢆ
⏝࠸ࡿ඲࡚ࡢື≀ᐇ㦂࡟㐺⏝ࡍࡿࠋ
㸰 ື≀ᐇ㦂㈐௵⪅ࡣࠊື≀ᐇ㦂➼ࡢᐇ᪋ࢆᙜࢭࣥࢱ࣮௨እࡢᶵ㛵࡟ጤクࡍࡿሙྜࡣࠊጤ
クඛ࡟࠾࠸࡚ࡶື≀ᐇ㦂➼࡟㛵ࡋ࡚ྛ⾜ᨻᶵ㛵ࡢᐃࡵࡿᇶᮏᣦ㔪࡟ᇶ࡙ࡁື≀ᐇ㦂➼ࡀ
ᐇ᪋ࡉࢀࡿࡇ࡜ࢆ☜ㄆࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸰❶ ື≀ᐇ㦂ጤဨ఍㸦,QVWLWXWLRQDO$QLPDO&DUH8VH&RPPLWWHH,$&8&㸧
― 243 ―
㸦ጤဨ఍ࡢタ⨨㸧
➨㸳᮲ ⟶⌮⪅ࡣࠊື≀ᐇ㦂ィ⏬ࡢᢎㄆࠊᐇ᪋≧ἣཬࡧ⤖ᯝࡢᢕᥱࠊ㣫㣴ಖ⟶᪋タཬࡧᐇ
㦂ᐊࡢᢎㄆࠊᩍ⫱カ⦎ࠊ⮬ᕫⅬ᳨࣭ホ౯ࠊ᝟ሗබ㛤ࡑࡢ௚ື≀ᐇ㦂➼ࡢ㐺ṇ࡞ᐇ᪋࡟㛵
ࡋ࡚ሗ࿌ཪࡣຓゝࢆ⾜࠺⤌⧊࡜ࡋ࡚ࠊᙜࢭࣥࢱ࣮࡟ື≀ᐇ㦂ጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ࡜
࠸࠺ࠋ㸧ࢆ⨨ࡃࠋ
㸦ጤဨ఍ࡢ௵ົ㸧
➨㸴᮲ ጤဨ఍ࡣࠊḟࡢ஦㡯ࢆᑂ㆟ཪࡣㄪᰝࡋࠊࡑࡢ⤖ᯝࢆ㝔㛗࡟ሗ࿌ࡍࡿ࡜࡜ࡶ࡟ࠊᚲ
せࡀ࠶ࢀࡤᨵၿࡢࡓࡵ࡟ពぢࢆ㏙࡭ࡿࠋ
୍ ື≀ᐇ㦂ィ⏬ࡢᑂᰝ࡟㛵ࡍࡿࡇ࡜
஧ ື≀ᐇ㦂ィ⏬ࡢᐇ᪋≧ἣཬࡧ⤖ᯝ࡟㛵ࡍࡿࡇ࡜
୕ ᪋タ➼ࡢ⟶⌮≧ἣཬࡧᐇ㦂ື≀ࡢ㣫㣴ಖ⟶≧ἣ࡟㛵ࡍࡿࡇ࡜
ᅄ ື≀ᐇ㦂➼ཬࡧᐇ㦂ື≀ࡢ㐺ṇ࡞ྲྀᢅ࠸୪ࡧ࡟㛵ಀἲ௧➼࡟㛵ࡍࡿᩍ⫱カ⦎ࡢෆᐜ
ཪࡣయไ࡟㛵ࡍࡿࡇ࡜
஬ ື≀ᐇ㦂➼࡟ಀࡿ⮬ᕫⅬ᳨࣭ホ౯࡟㛵ࡍࡿࡇ࡜
භ ࡑࡢ௚ື≀ᐇ㦂➼ࡢ㐺ṇ࡞ᐇ᪋ࡢࡓࡵ࡟ᚲせ࡞஦㡯࡟㛵ࡍࡿࡇ࡜
㸦ጤဨ఍ࡢᵓᡂ㸧
➨㸵᮲ ጤဨ఍ࡣࠊḟ࡟ᥖࡆࡿጤဨ࡛⤌⧊ࡍࡿࠋ
୍ ๪㝔㛗㸯ྡࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮㛗
஧ ┳ㆤ㒊ࠊ஦ົ㒊ࠊ⮫ᗋ᳨ᰝ⛉ࠊ⸆๣㒊ࡢ⫋ဨࡢ࠺ࡕ࠿ࡽᙜヱᡤᒓ㛗ࡀ᥎⸀ࡍࡿࡶࡢ
ྛ㸯ྡ
୕ ⮫ᗋ◊✲ࢭࣥࢱ࣮࡟࠾࠸࡚ື≀ᐇ㦂࡟ᦠࢃࡿ◊✲ဨࡢ࠺ࡕ⮫ᗋ◊✲ࢭࣥࢱ࣮㛗ࡀ᥎
⸀ࡍࡿࡶࡢ㸰ྡ
ᅄ ᐇ㦂ື≀ࡢᑓ㛛ᐙ㸯ྡ
஬ ື≀ᐇ㦂࡟㛵ࢃࡽ࡞࠸Ꮫ㆑⤒㦂ࢆ᭷ࡍࡿ⪅㸯ྡ
භ ࡑࡢ௚ࠊጤဨ㛗ࡀᚲせ࡜ㄆࡵࡓ⪅ⱝᖸྡ
㸰 ጤဨࡣࠊ㝔㛗ࡀ௵࿨ࡍࡿࠋ
㸦௵ᮇ㸧
➨㸶᮲ ๓᮲➨㸯㡯➨㸰ྕ࠿ࡽ➨㸴ྕࡲ࡛ࡢጤဨࡢ௵ᮇࡣࠊ㸰ᖺ࡜ࡍࡿࠋࡓࡔࡋࠊ෌௵ࢆ
ጉࡆ࡞࠸ࠋ
㸰 ๓᮲➨㸯㡯➨㸰ྕ࠿ࡽ➨㸴ྕࡲ࡛ࡢጤဨ࡟Ḟဨࡀ⏕ࡌࡓሙྜࡢ⿵Ḟጤဨࡢ௵ᮇࡣࠊ๓
௵⪅ࡢṧ௵ᮇ㛫࡜ࡍࡿࠋ
㸦ጤဨ㛗ཬࡧ๪ጤဨ㛗㸧
➨㸷᮲ ጤဨ఍࡟ጤဨ㛗ࢆ⨨ࡁࠊ๪㝔㛗ࢆࡶࡗ࡚඘࡚ࡿࠋ
㸰 ጤဨ㛗ࡣࠊ఍㆟ࢆᣍ㞟ࡋࠊࡑࡢ㆟㛗࡜࡞ࡿࠋ
㸱 ጤဨ఍࡟๪ጤဨ㛗ࢆ⨨ࡁࠊጤဨ㛗ࡢᣦྡࡍࡿጤဨࢆࡶࡗ࡚඘࡚ࡿࠋ
㸲 ๪ጤဨ㛗ࡣࠊጤဨ㛗ࢆຓࡅࠊጤဨ㛗࡟஦ᨾ➼ࡀ࠶ࡿ࡜ࡁࡣࠊࡑࡢ⫋ົࢆ௦⾜ࡍࡿࠋ
㸦఍㆟㸧
➨㸯㸮᮲ ጤဨ఍ࡣࠊጤဨࡢ㐣༙ᩘࡀฟᖍࡋ࡞ࡅࢀࡤࠊ㆟஦ࢆ㛤ࡃࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
㸰 ጤဨ఍ࡢ㆟஦ࡣࠊฟᖍࡋࡓጤဨࡢ㸱ศࡢ㸰௨ୖࡢከᩘ࡛Ỵࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸱 ጤဨࡣࠊ⮬ࡽࡀື≀ᐇ㦂㈐௵⪅࡜࡞ࡿື≀ᐇ㦂ィ⏬ࡢᑂ㆟࡟ຍࢃࡿࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
― 244 ―
㸦ពぢࡢ⫈ྲྀ㸧
➨㸯㸯᮲ ጤဨ㛗ࡀᚲせ࡜ㄆࡵࡓ࡜ࡁࡣࠊጤဨ఍࡟ጤဨ௨እࡢ⪅ࢆฟᖍࡉࡏࠊពぢࢆ⫈ྲྀ
ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦㛵ಀ⫋ဨࡢฟᖍ㸧
➨㸯㸰᮲ ጤဨ㛗ࡣࠊᚲせ࡟ᛂࡌࠊጤဨ఍࡟㛵ಀ⫋ဨࢆฟᖍࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦஦ົ㸧
➨㸯㸱᮲ ጤဨ఍ࡢ஦ົࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮஦ົ࡟࠾࠸࡚ฎ⌮ࡋࠊጤဨ఍㆟஦㘓➼ࡢస
ᡂཬࡧಖᏑ➼ࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ
➨㸱❶ ື≀ᐇ㦂➼ࡢᐇ᪋
㸦ື≀ᐇ㦂ィ⏬ࡢ❧᱌ࠊ⏦ㄳࠊᑂᰝ➼㸧
➨㸯㸲᮲ ື≀ᐇ㦂㈐௵⪅ࡣࠊື≀ᐇ㦂➼ࢆ⾜࠺ሙྜ࡟ࡣࠊ࠶ࡽ࠿ࡌࡵḟ࡟ᥖࡆࡿ஦㡯࡟
ࡘ࠸᳨࡚ウࡋࡓୖ࡛ື≀ᐇ㦂ィ⏬ࢆ❧᱌ࡋࠊู࡟ᐃࡵࡿື≀ᐇ㦂ィ⏬᭩࡞࡝ࢆ⟶⌮⪅࡟
ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍ ◊✲ࡢ┠ⓗࠊព⩏ཬࡧᐇ㦂ࡢᚲせᛶࢆ᫂☜࡟ࡍࡿࡇ࡜ࠋ
஧ ௦᭰ἲࢆ⪃៖ࡋࡓື≀ᐇ㦂ࡢ᪉ἲ
୕ ᐇ㦂ື≀ࡢ౑⏝๐ῶࡢࡓࡵࠊᐇ㦂┠ⓗ࡟㐺ࡋࡓᐇ㦂ື≀ࡢ✀ࠊᩘࠊ㑇ఏᏛⓗཬࡧᚤ
⏕≀Ꮫⓗရ㉁୪ࡧ࡟㣫㣴᮲௳ࢆ⪃៖ࡍࡿࡇ࡜ࠋ
ᅄ ᐇ㦂ື≀ࡢⱞ③ࡢ㍍ῶ
஬ ⱞ③ࡢ⛬ᗘࡢ㧗࠸ᐇ㦂㸦⮴Ṛⓗ࡞ẘᛶヨ㦂ࠊឤᰁᐇ㦂ࠊⓎ⒴ᐇ㦂ࠊᨺᑕ⥺↷ᑕᐇ㦂
➼㸧࡟࠾ࡅࡿே㐨ⓗ࢚ࣥࢻ࣏࢖ࣥࢺ㸦ᐇ㦂ື≀ࢆ⃭ࡋ࠸ⱞ③࠿ࡽゎᨺࡍࡿࡓࡵࡢᐇ㦂
ࢆᡴࡕษࡿࢱ࢖࣑ࣥࢢࢆ࠸࠺ࠋ㸧ࡢタᐃࢆ⪃៖ࡍࡿࡇ࡜ࠋ
㸰 ⟶⌮⪅ࡣࠊື≀ᐇ㦂㈐௵⪅࠿ࡽື≀ᐇ㦂ィ⏬᭩ࡢᥦฟࢆཷࡅࡓ࡜ࡁࡣࠊጤဨ఍࡟ᑂᰝ
ࢆ௜㆟ࡋࠊࡑࡢ⤖ᯝࢆᙜヱື≀ᐇ㦂㈐௵⪅࡟㏻▱ࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸱 ື≀ᐇ㦂㈐௵⪅ࡣࠊື≀ᐇ㦂ィ⏬࡟ࡘ࠸࡚⟶⌮⪅ࡢᢎㄆࢆᚓࡓᚋ࡛࡞ࡅࢀࡤࠊື≀ᐇ
㦂➼ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
㸲 ⟶⌮⪅ࡣࠊ➨㸰㡯ࡢつ⛬࡟ࡼࡾᢎㄆࢆ୚࠼ࡓື≀ᐇ㦂ィ⏬࡟ࡘ࠸࡚ࠊᐇ㦂ࡢᐇ᪋≧ἣ
࡟ᇶ࡙ࡃጤဨ఍ࡢຓゝࢆཷࡅ࡚ࠊᐇ㦂ࡢ⚗Ṇཪࡣ୰Ṇࢆ່࿌ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸦ື≀ᐇ㦂ィ⏬ࡢ᭦᪂࣭ኚ᭦㸧
➨㸯㸳᮲ ື≀ᐇ㦂㈐௵⪅ࡣࠊᢎㄆࡉࢀࡓື≀ᐇ㦂ィ⏬ࢆ᭦᪂ཪࡣኚ᭦ࡋࡼ࠺࡜ࡍࡿ࡜ࡁ
ࡣࠊู࡟ᐃࡵࡿື≀ᐇ㦂ィ⏬᭩㸦᭦᪂࣭ኚ᭦㸧࡟ࡼࡾ⟶⌮⪅࡟⏦ㄳࡍࡿࡶࡢ࡜ࡍࡿࠋ
㸦ᐇ㦂᧯స㸧
➨㸯㸴᮲ ື≀ᐇ㦂ᐇ᪋⪅ࡣࠊື≀ᐇ㦂➼ࡢᐇ᪋࡟࠶ࡓࡗ࡚ࡣࠊἲࠊ㣫㣴ಖ⟶ᇶ‽ཬࡧᣦ
㔪➼࡟༶ࡍࡿ࡜࡜ࡶ࡟ࠊ≉࡟௨ୗࡢ஦㡯ࢆ㑂Ᏺࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍ 㐺ษ࡟⥔ᣢ⟶⌮ࡉࢀࡓ᪋タ➼࡟࠾࠸࡚ື≀ᐇ㦂➼ࢆ⾜࠺ࡇ࡜ࠋ
஧ ື≀ᐇ㦂ィ⏬᭩࡟グ㍕ࡉࢀࡓ஦㡯ཬࡧḟ࡟ᥖࡆࡿ஦㡯ࢆ㑂Ᏺࡍࡿࡇ࡜ࠋ
࢔ 㯞㓉⸆ࠊ㙠③⸆ཪࡣ㙠㟼⸆➼ࢆ㐺ษ࡟౑⏝ࡋࠊᐇ㦂ື≀࡟ⱞ③ࢆ୚࠼࡞࠸ࡼ࠺ດ
ࡵࡿࡇ࡜ࠋ
࢖ ᐇ㦂ࡢ⤊஢ࡢ᫬ᮇ㸦ே㐨ⓗ࢚ࣥࢻ࣏࢖ࣥࢺࢆྵࡴࠋ㸧ࢆ㓄៖ࡍࡿࡇ࡜ࠋ
࢘ ື≀ᐇ㦂➼ࡢᐇ᪋࡟࠾࠸࡚ࡣࠊ㐺ษ࡞⾡ᚋ⟶⌮ࢆ⾜࠺ࡇ࡜ࠋ
― 245 ―
࢚ ື≀ᐇ㦂➼ࡢ⤊஢᫬ཪࡣᐇ㦂ື≀ࡀᅇ᚟ࡢぢ㎸ࡀ࡞࠸࡜ุ᩿ࡋࡓ࡜ࡁࡣࠊฟ᮶ࡿ
㝈ࡾⱞ③ࢆకࢃ࡞࠸᪉ἲ࡟ࡼࡾࠊᐇ㦂ື≀ࢆᏳᴦṚࡉࡏࡿࡇ࡜ࠋ
୕ Ᏻ඲⟶⌮࡟ὀពࢆᡶ࠺࡭ࡁᐇ㦂㸦≀⌮ⓗࠊ໬Ꮫⓗ࡟༴㝤࡞ᮦᩱࠊ⑓ཎయࠊ㑇ఏᏊ⤌
᥮࠼ື≀➼ࢆ⏝࠸ࡿᐇ㦂ࢆ࠸࠺ࠋ㸧࡟ࡘ࠸࡚ࡣࠊ㛵ಀἲ௧➼ཬࡧᙜ㝔࡟࠾ࡅࡿ㛵㐃ࡍ
ࡿつ⛬➼࡟ᚑ࠺ࡇ࡜ࠋ
ᅄ ๓㡯ࡢື≀ᐇ㦂➼ࡣࠊᏳ඲ࢆ☜ಖࡍࡿࡓࡵ࡟ᚲせ࡞タഛࢆ᭷ࡍࡿ᪋タ➼࡛ᐇ᪋ࡍࡿ
ࡇ࡜ࠋ
஬ ᐇ㦂ᐇ᪋࡟ඛ❧ࡕᚲせ࡞ᐇ㦂ᡭᢏ➼ࡢ⩦ᚓ࡟ດࡵࡿࡇ࡜ࠋ
භ ౵くᛶࡢ㧗࠸኱つᶍ࡞Ꮡ࿨ᡭ⾡࡟࠶ࡓࡗ࡚ࡣࠊ⤒㦂➼ࢆ᭷ࡍࡿ⪅ࡢᣦᑟୗ࡛⾜࠺ࡇ
࡜ࠋ
㸦ື≀ᐇ㦂ィ⏬ࡢሗ࿌㸧
➨㸯㸵᮲ ື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ࢆ⤊஢ཪࡣ୰Ṇࡋࡓ࡜ࡁࡣࠊู࡟ᐃࡵࡿື≀ᐇ㦂➼࡟
㛵ࡍࡿሗ࿌᭩࡟ࡼࡾࠊ⟶⌮⪅࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ື≀ᐇ㦂㈐௵⪅ࡣࠊẖᖺᗘ⤊஢ᚋ࡟ࠊู࡟ᐃࡵࡿື≀ᐇ㦂ሗ࿌᭩࡟ࡼࡾࠊᙜヱᖺᗘࡢ
ᐇ㦂≧ἣࢆ⟶⌮⪅࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸲❶ ᪋タ➼
㸦㣫㣴ಖ⟶᪋タࡢᢎㄆ㸧
➨㸯㸶᮲ ᐇ㦂ື≀⟶⌮⪅ࡣࠊ㣫㣴ಖ⟶᪋タࢆタ⨨ཪࡣኚ᭦㸦௨ୗࠕタ⨨➼ࠖ࡜࠸࠺ࠋ㸧
ࢆࡍࡿሙྜࡣࠊື≀ᐇ㦂㈐௵⪅ࢆ⤒⏤ࡋู࡚࡟ᐃࡵࡿ㣫㣴ಖ⟶᪋タタ⨨ᢎㄆ⏦ㄳ᭩ࢆ⟶
⌮⪅࡟ᥦฟࡋࠊᢎㄆࢆᚓࡿࡶࡢ࡜ࡍࡿࠋ
㸰 ⟶⌮⪅ࡣࠊ⏦ㄳࡉࢀࡓ㣫㣴ಖ⟶᪋タࢆື≀ᐇ㦂ጤဨ఍࡟ㄪᰝࡉࡏࠊጤဨ఍ࡢㄪᰝ⤖ᯝ
ཬࡧຓゝ࡟ࡼࡾࠊᢎㄆࢆ⾜࠺࠿ྰ࠿ࡢỴᐃࢆ⾜࠸ࠊື≀ᐇ㦂㈐௵⪅ࢆ⤒⏤ࡋ࡚ࠊࡑࡢ⤖
ᯝࢆᐇ㦂ື≀⟶⌮⪅࡟㏻▱ࡍࡿࠋ
㸱 ᐇ㦂ື≀ࡢ㣫㣴ⱝࡋࡃࡣಖ⟶ཪࡣື≀ᐇ㦂➼ࡣࠊ⟶⌮⪅ࡢᢎㄆࢆᚓࡓ㣫㣴ಖ⟶᪋タ࡛
࡞ࡅࢀࡤ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋ
㸦㣫㣴ಖ⟶᪋タࡢせ௳㸧
➨㸯㸷᮲ 㣫㣴ಖ⟶᪋タࡢタ⨨➼࡟ಀࡿせ௳ࡣ௨ୗࡢ࡜࠾ࡾ࡜ࡍࡿࠋ
୍ 㐺ษ࡞ ᗘࠊ‵ᗘࠊ᥮Ẽࠊ᫂ࡿࡉ➼ࢆಖࡘࡇ࡜ࡀ࡛ࡁࡿᵓ㐀➼࡛࠶ࡿࡇ࡜ࠋ
஧ ື≀✀ࠊ㣫㣴ಖ⟶ᩘ➼࡟ᛂࡌࡓ㣫⫱タഛࢆ᭷ࡍࡿࡇ࡜ࠋ
୕ ᗋࠊෆቨ➼ࡢΎᤲࠊᾘẘ➼ࡀᐜ᫆࡞ᵓ㐀࡛ࠊჾᮦࡢὙίࠊᾘẘ➼ࢆ⾜࠺⾨⏕タഛࢆ
᭷ࡍࡿࡇ࡜ࠋ
ᅄ ᐇ㦂ື≀ࡀ㐓㉮ࡋ࡞࠸ᵓ㐀ཬࡧᙉᗘࢆ᭷ࡍࡿࡇ࡜ࠋ
஬ ⮯Ẽࠊ㦁㡢ࠊᗫᲠ≀➼࡟ࡼࡿ࿘㎶⎔ቃ࡬ࡢᝏᙳ㡪ࢆ㜵Ṇࡍࡿᥐ⨨ࡀ࡜ࡽࢀ࡚࠸ࡿࡇ
࡜ࠋ
භ ᐇ㦂ື≀⟶⌮⪅㸦◊✲ᐊ㒊㛗ࡲࡓࡣ◊✲ᐊ㛗㸧ࡀ࠾࠿ࢀ࡚࠸ࡿࡇ࡜ࠋ
㸦ᐇ㦂ᐊࡢタ⨨㸧
➨㸰㸮᮲ ᐇ㦂ື≀⟶⌮⪅ࡣࠊ㣫㣴ಖ⟶᪋タ௨እ࡟࠾࠸࡚ࠊᐇ㦂ᐊࢆタ⨨➼ࡍࡿሙྜࡣࠊ
ື≀ᐇ㦂㈐௵⪅ࢆ⤒⏤ࡋู࡚࡟ᐃࡵࡿࠕᐇ㦂ᐊタ⨨ᢎㄆ⏦ㄳ᭩ࠖࢆᥦฟࡋࠊ⟶⌮⪅ࡢᢎ
ㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ⟶⌮⪅ࡣࠊ⏦ㄳࡉࢀࡓᐇ㦂ᐊࢆጤဨ఍࡟ㄪᰝࡉࡏࠊጤဨ఍ࡢㄪᰝ⤖ᯝཬࡧຓゝ࡟ࡼࡾࠊ
ᢎㄆࢆ⾜࠺࠿ྰ࠿ࡢỴᐃࢆ⾜࠸ࠊື≀ᐇ㦂㈐௵⪅ࢆ⤒⏤ࡋ࡚ᐇ㦂ື≀⟶⌮⪅࡟㏻▱ࡍࡿࠋ
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㸱 ື≀ᐇ㦂➼ࡣࠊ⟶⌮⪅ࡢᢎㄆࢆᚓࡓᐇ㦂ᐊ࡛࡞ࡅࢀࡤ⾜࠺ࡇ࡜ࡀ࡛ࡁ࡞࠸ࠋࡲࡓࠊ㸲
㸶᫬㛫௨ෆࡢ୍᫬ⓗಖ⟶ࡢሙྜ࡟࠶ࡗ࡚ࡶࠊྠᵝ࡜ࡍࡿࠋ
㸦ᐇ㦂ᐊࡢせ௳㸧
➨㸰㸯᮲ ᐇ㦂ᐊࡢタ⨨➼࡟ಀࡿせ௳ࡣ௨ୗࡢ࡜࠾ࡾ࡜ࡍࡿࠋ
୍ ᐇ㦂ື≀ࡀ㐓㉮ࡋ࡞࠸ᵓ㐀ཬࡧᙉᗘࢆ᭷ࡋࠊᐇ㦂ື≀ࡀᐊෆ࡛㐓㉮ࡋ࡚ࡶᤕ⋓ࡋࡸ
ࡍ࠸⎔ቃࡀ⥔ᣢࡉࢀ࡚࠸ࡿࡇ࡜ࠋ
஧ ᤼ἥ≀ࠊ⾑ᾮ➼࡟ࡼࡿởᰁ࡟ᑐࡋ࡚ࠊΎᤲཬࡧᾘẘࡀᐜ᫆࡞ᵓ㐀࡛࠶ࡿࡇ࡜ࠋ
୕ ᖖ࡟Ύ₩࡞≧ែࢆಖࡕࠊ⮯Ẽࠊ㦁㡢ࠊᗫᲠ≀➼࡟ࡼࡿ࿘㎶⎔ቃ࡬ࡢᝏᙳ㡪ࢆ㜵Ṇࡍ
ࡿᥐ⨨ࡀ࡜ࡽࢀ࡚࠸ࡿࡇ࡜ࠋ
㸦᪋タ➼ࡢ⥔ᣢ⟶⌮ཬࡧᨵၿ㸧
➨㸰㸰᮲ ⟶⌮⪅ࡣࠊᐇ㦂ື≀ࡢ㐺ษ࡞⟶⌮୪ࡧ࡟ື≀ᐇ㦂➼ࡢ㐙⾜࡟ᚲせ࡞᪋タ➼ࡢ⥔
ᣢ⟶⌮ཬࡧᨵၿ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦᪋タࡢᗫṆ㸧
➨㸰㸱᮲ ᐇ㦂ື≀⟶⌮⪅ࡣࠊ᪋タ➼ࢆᗫṆࡍࡿሙྜࡣࠊື≀ᐇ㦂㈐௵⪅ࢆ⤒⏤ࡋ࡚ࠊู
࡟ᐃࡵࡿ᪋タ➼ᗫṆᒆ࡟ࡼࡾࠊ㏿ࡸ࠿࡟⟶⌮⪅࡟ᒆࡅฟ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ⟶⌮⪅ࡣࠊ᪋タ➼ࢆᗫṆࡍࡿሙྜࡣࠊᚲせ࡟ᛂࡌ࡚ࠊᐇ㦂ື≀⟶⌮⪅࡜༠ຊࡋࠊ㣫㣴
ಖ⟶୰ࡢᐇ㦂ື≀ࢆࠊ௚ࡢ㣫㣴ಖ⟶᪋タ࡟ㆡࡾΏࡍࡼ࠺ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸳❶ ᐇ㦂ື≀ࡢ㣫㣴ཬࡧಖ⟶
㸦࣐ࢽࣗ࢔ࣝࡢసᡂ࡜࿘▱㸧
➨㸰㸲᮲ ⟶⌮⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࠊ㣫㣴ཬࡧಖ⟶ࡢ࣐ࢽࣗ࢔ࣝࢆᐃࡵࠊື≀ᐇ㦂ᐇ
᪋⪅ཬࡧ㣫㣴⪅࡟࿘▱ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᐇ㦂ື≀ࡢ೺ᗣཬࡧᏳ඲ࡢಖᣢ㸧
➨㸰㸳᮲ ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊ㣫㣴ಖ⟶ᇶ‽ࢆ㑂Ᏺࡋࠊᐇ㦂
ື≀ࡢ೺ᗣཬࡧᏳ඲ࡢಖᣢ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ᐇ㦂ື≀ࡢᑟධ㸧
➨㸰㸴᮲ ⟶⌮⪅➼ࡣࠊᐇ㦂ື≀ࡢᑟධ࡟࠶ࡓࡗ࡚ࠊ㛵ಀἲ௧ཬࡧᣦ㔪➼࡟ᇶ࡙ࡁ㐺ṇ࡟
⟶⌮ࡋ࡚࠸ࡿᶵ㛵ࡼࡾᑟධࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ᐇ㦂ື≀⟶⌮⪅ࡣࠊᐇ㦂ື≀ࡢᑟධ࡟࠶ࡓࡗ࡚ࠊ㐺ษ࡞᳨␿ࠊ㝸㞳㣫⫱➼ࢆ⾜ࢃ࡞ࡅ
ࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱 ᐇ㦂ື≀⟶⌮⪅ࡣࠊᐇ㦂ື≀ࡢ㣫㣴⎔ቃ࡬ࡢ㡰໬࣭㡰ᛂࢆᅗࡿࡓࡵࡢᚲせ࡞ᥐ⨨ࢆㅮ
ࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦⤥㣵࣭⤥Ỉ㸧
➨㸰㸵᮲ ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊᐇ㦂ື≀ࡢ⏕⌮ࠊ⏕ែࠊ⩦ᛶ
➼࡟ᛂࡌ࡚ࠊ㐺ษ࡟⤥㣵࣭⤥Ỉࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦೺ᗣ⟶⌮㸧
➨㸰㸶᮲ ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊᐇ㦂┠ⓗ௨እࡢയᐖཬࡧ⑌⑓
ࢆண㜵ࡍࡿࡓࡵࠊᐇ㦂ື≀࡟ᚲせ࡞೺ᗣ⟶⌮ࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
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㸰 ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊᐇ㦂ື≀ࡀᐇ㦂┠ⓗ௨እࡢയᐖཪࡣ
⑌⑓࡟࠿࠿ࡗࡓሙྜࡣࠊ㐺ษ࡞἞⒪➼ࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦␗✀ཪࡣ」ᩘࡢᐇ㦂ື≀ࡢ㣫⫱㸧
➨㸰㸷᮲ ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊ␗✀ཪࡣ」ᩘࡢᐇ㦂ື≀ࢆྠ
୍᪋タෆ࡛㣫㣴ཬࡧಖ⟶ࡍࡿሙྜࡣࠊࡑࡢ⤌ࡳྜࢃࡏࢆ⪃៖ࡋࡓ཰ᐜࢆ⾜ࢃ࡞ࡅࢀࡤ࡞
ࡽ࡞࠸ࠋ
㸦グ㘓ࡢಖᏑཬࡧሗ࿌㸧
➨㸱㸮᮲ ᐇ㦂ື≀⟶⌮⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ື≀ࡢධᡭඛࠊ㣫⫱ᒚṔࠊ⑓Ṕ➼
࡟㛵ࡍࡿグ㘓ࢆᩚഛࡋࠊಖᏑࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ᐇ㦂ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ࡢ㣫⫱࡟ᙜࡓࡗ࡚ࡣࠊ㣫⫱ື≀ࡢ඲ᩘࢆ௘యࡶྵࡵ࡚ẖ㐌ィ
ࡋࠊ㣫⫱ᩘ⟶⌮⡙࡟グ㘓ࡋ࡚ࠊᐇ㦂ື≀⟶⌮⪅࡟ሗ࿌ࡍࡿࡇ࡜ࠋ
㸱 ᐇ㦂ᐇ᪋⪅ࡣࠊసᴗ๓ᚋ࡟సᴗࡋࡓࢣ࣮ࢪࡈ࡜࡟ື≀ᩘኚ໬࡟ㄗࡾࡢ࡞࠸ࡇ࡜ࢆィ
࣭グ㘓ࡍࡿࡇ࡜ࠋ
㸲 ᐇ㦂ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ᐊࡢධ㏥ฟࢆ⟶⌮⡙࡟グ㘓ࡍࡿࡇ࡜ࠋ
㸳 ື≀ᐇ㦂㈐௵⪅ࡣࠊ㣫㣴ಖ⟶ࡋࡓᐇ㦂ື≀ࡢ✀㢮࡜ᩘ➼࡟ࡘ࠸࡚ࠊᐃᮇⓗ࡟ጤဨ఍࡛
ᑂᰝᚋࠊ⟶⌮⪅࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦ㆡΏࡢ㝿ࡢ᝟ሗᥦ౪㸧
➨㸱㸯᮲ ⟶⌮⪅➼ࡣࠊᐇ㦂ື≀ࡢㆡΏ࡟࠶ࡓࡗ࡚ࡣࠊࡑࡢ≉ᛶࠊ㣫㣴ಖ⟶ࡢ᪉ἲࠊឤᰁ
ᛶ⑌⑓➼࡟㛵ࡍࡿ᝟ሗࢆᥦ౪ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦㍺㏦㸧
➨㸱㸰᮲ ⟶⌮⪅➼ࡣࠊᐇ㦂ື≀ࡢ㍺㏦࡟࠶ࡓࡗ࡚ࠊ㣫㣴ಖ⟶ᇶ‽ࢆ㑂Ᏺࡋࠊᐇ㦂ື≀ࡢ
೺ᗣཬࡧᏳ඲ࡢ☜ಖ୪ࡧ࡟ே࡬ࡢ༴ᐖ㜵Ṇ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸴❶ Ᏻ඲⟶⌮
㸦༴ᐖ㜵Ṇ㸧
➨㸱㸱᮲ ື≀ᐇ㦂㈐௵⪅ࡣࠊ㐓㉮ࡋࡓᐇ㦂ື≀ࡢᤕ⋓ࡢ᪉ἲ➼ࢆ࠶ࡽ࠿ࡌࡵᐃࡵ࡞ࡅࢀ
ࡤ࡞ࡽ࡞࠸ࠋ
㸰 ື≀ᐇ㦂㈐௵⪅ࡣࠊே࡟༴ᐖࢆຍ࠼ࡿ➼ࡢ࠾ࡑࢀࡢ࠶ࡿᐇ㦂ື≀ࡀ᪋タ➼እ࡟㐓㉮ࡋ
ࡓሙྜ࡟ࡣࠊ⟶⌮⪅࡟ሗ࿌ࡍࡿ࡜࡜ࡶ࡟ࠊ㏿ࡸ࠿࡟㛵ಀᶵ㛵࡬㐃⤡ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱 ື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅࡬ࡢᐇ㦂ື≀⏤᮶ࡢ
ឤᰁ⑕ࠊᐇ㦂ື≀࡟ࡼࡿညയ➼࡟ᑐࡍࡿண㜵ᥐ⨨ࢆㅮࡌࡿ࡜࡜ࡶ࡟ࠊឤᰁ⑕➼ࡢⓎ⏕᫬
࡟ࡣᚲせ࡞ᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸲 ື≀ᐇ㦂㈐௵⪅ࡣࠊẘ࡬ࡧ➼ࡢ᭷ẘື≀ࡢ㣫㣴ཪࡣಖ⟶ࢆࡍࡿሙྜࡣࠊே࡬ࡢ༴ᐖࡢ
Ⓨ⏕ࡢ㜵Ṇࡢࡓࡵࠊ㣫㣴ಖ⟶ᇶ‽࡟ᇶ࡙ࡁᚲせ࡞஦㡯ࢆู࡟ᐃࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸳 ື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ື≀ࡢ㣫㣴ཬࡧື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ಀࡢ࡞࠸⪅ࡀᐇ㦂ື≀
➼࡟᥋ゐࡋ࡞࠸ࡼ࠺ࠊᚲせ࡞ᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸦⥭ᛴ᫬ࡢᑐᛂ㸧
➨㸱㸲᮲ ື≀ᐇ㦂㈐௵⪅ࡣࠊᆅ㟈ࠊⅆ⅏➼ࡢ⥭ᛴ᫬࡟࡜ࡿ࡭ࡁᥐ⨨ࡢィ⏬ࢆ࠶ࡽ࠿ࡌࡵ
సᡂࡋࠊ㛵ಀ⪅࡟ᑐࡋ࡚࿘▱ࢆᅗࡽ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ື≀ᐇ㦂㈐௵⪅ࡣࠊ⥭ᛴ஦ែⓎ⏕᫬࡟࠾࠸࡚ࠊᐇ㦂ື≀ࡢಖㆤཬࡧᐇ㦂ື≀ࡢ㐓㉮࡟
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ࡼࡿ༴ᐖ㜵Ṇ࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸵❶ ᩍ⫱カ⦎
㸦ᩍ⫱カ⦎㸧
➨㸱㸳᮲ ᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ཬࡧ㣫㣴⪅ࡣࠊጤဨ఍ࡀᖺ࡟୍ᅇ⛬ᗘ୺ദࡍ
ࡿ௨ୗࡢ஦㡯࡟㛵ࡍࡿᡤᐃࡢᩍ⫱カ⦎ࢆཷࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
୍ 㛵ಀἲ௧ࠊᣦ㔪➼ࠊᙜ㝔ࡢᐃࡵࡿつ๎➼
஧ ື≀ᐇ㦂➼ࡢ᪉ἲ࡟㛵ࡍࡿᇶᮏⓗ஦㡯
୕ ᐇ㦂ື≀ࡢ㣫㣴ಖ⟶࡟㛵ࡍࡿᇶᮏⓗ஦㡯
ᅄ Ᏻ඲☜ಖཬࡧᏳ඲⟶⌮࡟㛵ࡍࡿ஦㡯
஬ ࡑࡢ௚㐺ษ࡞ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿ஦㡯
㸰 ጤဨ఍ࡣࠊᩍ⫱カ⦎ࡢᐇ᪋᪥ࠊᩍ⫱ෆᐜࠊㅮᖌཬࡧཷㅮ⪅ྡ࡟㛵ࡍࡿグ㘓ࢆᩚഛࡋࠊ
ಖᏑࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
➨㸶❶ ⮬ᕫⅬ᳨࣭ホ౯ཬࡧ᳨ド
㸦⮬ᕫⅬ᳨࣭ホ౯ཬࡧ᳨ド㸧
➨㸱㸴᮲ ⟶⌮⪅ࡣࠊጤဨ఍࡟ࠊᩥ⛉┬ᇶᮏᣦ㔪࡟ᑐࡍࡿ㐺ྜᛶ࡟㛵ࡋ⮬ᕫⅬ᳨࣭ホ౯ࢆ
⾜ࢃࡏ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰 ጤဨ఍ࡣࠊື≀ᐇ㦂➼ࡢᐇ᪋≧ἣ➼࡟㛵ࡍࡿ⮬ᕫⅬ᳨࣭ホ౯ࢆᖺ㸯ᅇ⾜࠸ࠊࡑࡢ⤖ᯝ
ࢆ⟶⌮⪅࠾ࡼࡧᅜ❧⑓㝔ᶵᵓᮏ㒊⥲ྜ◊✲ࢭࣥࢱ࣮࡟ሗ࿌ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱 ጤဨ఍ࡣࠊ⟶⌮⪅ࠊື≀ᐇ㦂㈐௵⪅ࠊᐇ㦂ື≀⟶⌮⪅ࠊື≀ᐇ㦂ᐇ᪋⪅ࠊ㣫㣴⪅➼࡟ࠊ
⮬ᕫⅬ᳨࣭ホ౯ࡢࡓࡵࡢ㈨ᩱࢆᥦฟࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
➨㸷❶ ᝟ሗࡢබ⾲
㸦᝟ሗࡢබ⾲㸧
➨㸱㸵᮲ ᙜࢭࣥࢱ࣮࡟࠾ࡅࡿື≀ᐇ㦂➼࡟㛵ࡍࡿつ⛬➼ࠊᐇ㦂ື≀ࡢ㣫㣴ಖ⟶≧ἣࠊ⮬
ᕫⅬ᳨࣭ホ౯ཬࡧ᳨ドࡢ⤖ᯝ➼࡟㛵ࡍࡿ᝟ሗ࡟ࡘ࠸࡚ࠊẖᖺ㸯ᅇ⛬ᗘබ⾲ࡍࡿࡶࡢ࡜ࡍ
ࡿࠋ
➨㸯㸮❶ 㞧๎
㸦ᐇ㦂ື≀௨እࡢື≀ࡢ౑⏝㸧
➨㸱㸶᮲ ᐇ㦂ື≀௨እࡢື≀ࢆ౑⏝ࡍࡿື≀ᐇ㦂➼࡟ࡘ࠸࡚ࡣࠊ㣫㣴ಖ⟶ᇶ‽ࡢ㊃᪨࡟
ἢࡗ࡚⾜࠺ࡼ࠺ດࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦⿵๎㸧
➨㸱㸷᮲ ࡇࡢつ⛬࡟ᐃࡵࡿࡶࡢࡢ࡯࠿ࠊື≀ᐇ㦂࡟㛵ࡋᚲせ࡞஦㡯ࡣࠊู࡟ᐃࡵࡿࡇ࡜
ࡀ࡛ࡁࡿࠋ
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
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㸦つ⛬ࡢᗫṆ㸧
ࡇࡢつ⛬ࡢ᪋⾜࡟ేࡏ࡚ࠊḟ࡟ᥖࡆࡿᚑ๓ࡢつ⛬ࡣᗫṆࡍࡿࠋ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ື≀ᐇ㦂ጤဨ఍つ⛬
㝃 ๎㸦➨㸵᮲➨㸯㡯ཬࡧ➨㸷᮲➨㸯㡯㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸲ᖺ㸯㸯᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
㝃 ๎㸦➨㸱᮲➨㸰㡯㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸳ᖺ㸷᭶㸳᪥࠿ࡽ᪋⾜ࡍࡿࠋ
㝃 ๎㸦➨㸯᮲ࠊ➨㸴᮲ཬࡧ➨㸯㸲᮲㛵ಀ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢつ⛬ࡣࠊᖹᡂ㸰㸵ᖺ㸴᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
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ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ື≀ᐇ㦂ᣦ㔪
Ϩ ┠ⓗ
ࡇࡢᣦ㔪ࡣ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮㸦௨ୗ
ࠕ◊✲ࢭࣥࢱ࣮ࠖ࡜࠸࠺ࠋ㸧࡟࠾࠸࡚ື≀ᐇ㦂ࢆィ⏬ࡋࠊᐇ᪋ࡍࡿ㝿࡟㑂Ᏺࡍ࡭ࡁ
஦㡯ࢆ♧ࡍࡇ࡜࡟ࡼࡾࠊ⛉ᏛⓗほⅬ࠿ࡽࡣࡶ࡜ࡼࡾࠊື≀⚟♴ࡢほⅬ࠿ࡽࡶ㐺ṇ࡞
ື≀ᐇ㦂ࡢᐇ᪋ࢆಁࡍࡇ࡜ࢆ┠ⓗ࡜ࡍࡿࠋ
ϩ ᐃ⩏
ࡇࡢᣦ㔪࡟࠾࠸࡚ࠊḟࡢྛྕ࡟ᥖࡆࡿ⏝ㄒࡢព⩏ࡣࠊᙜヱྛྕ࡟ᐃࡵࡿ࡜ࡇࢁ࡟
ࡼࡿࠋ
㸯㸬⟶⌮⪅
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮㝔㛗
㸰㸬ື≀ᐇ㦂㈐௵⪅
ື≀ᐇ㦂➼ࡢᐇ᪋࡟㛵ࡍࡿᴗົࢆ⤫ᣓࡍࡿ⪅ࢆ࠸࠺ࠋ㸦⮫ᗋ◊✲ࢭࣥࢱ࣮㛗㸧
㸱㸬ᐇ㦂ື≀⟶⌮⪅
ᐇ㦂ື≀࡟㛵ࡍࡿ▱㆑ཬࡧ⤒㦂ࢆ᭷ࡍࡿ⪅࡛ࠊ⟶⌮⪅ࢆ⿵బࡋࠊᐇ㦂ື≀ࡢ⟶
⌮ࢆᢸᙜࡍࡿ⪅ࢆ࠸࠺ࠋ㸦◊✲㒊㛗࠶ࡿ࠸ࡣ◊✲ᐊ㛗㸧
㸲㸬ື≀ᐇ㦂ᐇ᪋⪅
ື≀ᐇ㦂➼ࢆ⾜࠺⪅௨ୗᐇ᪋⪅
㸳㸬㣫㣴⪅
ᐇ㦂ື≀⟶⌮⪅ཪࡣື≀ᐇ㦂ᐇ᪋⪅ࡢୗ࡛ᐇ㦂ື≀ࡢ㣫㣴ཪࡣಖ⟶࡟ᚑ஦ࡍ
ࡿ⪅ࢆ࠸࠺ࠋ
㸴㸬ᐇ㦂ື≀ࡢᑓ㛛ᐙ
ᐇ㦂ື≀Ꮫࢆ⩦ᚓࡋࡓ⪅ཪࡣᐇ㦂ື≀ཬࡧື≀ᐇ㦂࡟ࡘ࠸࡚༑ศ࡞▱㆑࣭⤒㦂
ࢆ᭷ࡍࡿ⪅
㸵㸬᪋タ࣭タഛ
ᐇ㦂ື≀ࡢ㣫⫱ࡶࡋࡃࡣಖ⟶ࡲࡓࡣᐇ㦂➼ࢆ⾜࠺ࡓࡵࡢ᪋タ࣭タഛ
㸶㸬ᐇ㦂ື≀
ᐇ㦂ື≀ࡢ฼⏝࡟౪ࡍࡿࡓࡵ࡟㣫⫱ࡋࠊࡲࡓࡣಖ⟶ࡋ࡚࠸ࡿ့ங㢮࡟ᒓࡍࡿື
≀㸦᪋タ࡟ᑟධࡍࡿࡓࡵ࡟㍺㏦୰ࡢࡶࡢࢆྵࡴ㸧
Ϫ 㐺⏝⠊ᅖ
㸯㸬ࡇࡢᣦ㔪ࡣࠊ◊✲ࢭࣥࢱ࣮࡛⾜ࢃࢀࡿࡍ࡭࡚ࡢື≀ᐇ㦂࡟㐺⏝ࡉࢀࡿࠋ
㸰㸬့ங㢮࡟ᒓࡍࡿື≀௨እࡢື≀ࢆ⏝࠸ࡓᐇ㦂࡟ࡘ࠸࡚ࡶࡇࡢᣦ㔪ࡢ㊃᪨࡟ἢࡗ
࡚ᐇ᪋ࡍࡿࡼ࠺ດࡵࡿࡶࡢ࡜ࡍࡿࠋ
ϫ ື≀ᐇ㦂ጤဨ఍
㸯㸬⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮࡟ࡇࡢᣦ㔪ࡢ㐺ṇ࡞㐠⏝ࢆᅗࡿࡓ
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ࡵࠊ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ື≀ᐇ㦂ጤဨ఍㸦௨ୗࠕጤဨ఍ࠖ
࡜࠸࠺ࠋ㸧ࢆ⨨ࡃࠋ
㸰㸬ጤဨ఍࡟㛵ࡍࡿ஦㡯ࡣࠊู࡟ᐃࡵࡿࠋ
Ϭ ᐇ㦂ィ⏬ࡢ❧᱌
㸯㸬ᐇ᪋⪅ࡣࠊື≀ᐇ㦂ࡢ⠊ᅖࢆ◊✲ࡢ┠ⓗ࡟ᚲせ࡞᭱ᑠᗘ࡟࡜࡝ࡵࡿࡓࡵࠊ㐺ṇ
࡞ᐇ㦂ື≀ࡢ㑅ᢥཬࡧᐇ㦂᪉ἲࡢ᳨ウࢆ⾜࠺࡜࡜ࡶ࡟ࠊ㐺ṇ࡞ື≀ᐇ㦂࡟ᚲせ࡞
㣫⫱⎔ቃࡑࡢ௚ࡢ᮲௳ࢆ☜ಖࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ࡢ㑅ᢥ࡟ᙜࡓࡗ࡚ࠊᐇ㦂┠ⓗ࡟㐺ࡋࡓື≀✀ࡢ㑅ᐃࠊᐇ㦂
ᡂ⦼ࡢ⢭ᗘࡸ෌⌧ᛶࢆᕥྑࡍࡿᐇ㦂ື≀ࡢᩘࠊ㑇ఏᏛⓗ࣭ᚤ⏕≀Ꮫⓗရ㉁ཬࡧ㣫
⫱᮲௳➼ࢆ⪃៖ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋᚤ⏕≀Ꮫⓗရ㉁࡟㛵ࡋ࡚ࡣࠊ⟶⌮⪅ࡢᣦ♧
࡟ᚑࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱㸬ᐇ᪋⪅ࡣࠊᐇ㦂ィ⏬ࡢ❧᱌࡟ᙜࡓࡗ࡚ࠊᚲせ࡟ᛂࡌ࡚ࠊື≀ᐇ㦂⟶⌮⪅ⱝࡋࡃ
ࡣᐇ㦂ື≀ࡢᑓ㛛ᐙཪࡣጤဨ఍࡟ຓゝཬࡧᣦᑟࢆồࡵࠊ᭷ຠ࠿ࡘ㐺ṇ࡞ᐇ㦂࡟ດ
ࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸲㸬ᐇ᪋⪅ࡣࠊ๓㡯ࡢ❧᱌ࡋࡓᐇ㦂ィ⏬࡟ࡘ࠸࡚ࠊጤဨ఍ࡢᑂᰝࢆཷࡅ࡞ࡅࢀࡤ࡞
ࡽ࡞࠸ࠋ
ϭ ᐇ㦂ື≀ࡢ᳨཰ཬࡧ᳨␿
㸯㸬ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ࡢⓎὀ᮲௳ࠊ␗ᖖཬࡧṚஸࡢ᭷↓ࢆ☜ㄆࡍࡿ࡜࡜ࡶ࡟ࠊᐇ
㦂ື≀ࡢ㍺㏦ࡢ᪉ἲཬࡧ᫬㛫➼ࢆᢕᥱࡋ࡚࠾࠿࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ㦂⪅ࡣࠊᑟධࡉࢀࡓᐇ㦂ື≀࡟ࡘ࠸࡚ࠊఏᰁ⑓ࡑࡢ௚⑌⑓ࡢ᳨␿ࢆ⾜ࢃ࡞ࡅ
ࢀࡤ࡞ࡽ࡞࠸ࠋ
Ϯ ᐇ㦂ື≀ࡢ㣫⫱⟶⌮
㸯㸬ື≀㣫⫱ࡢ᪋タ࣭タഛཬࡧ㣫⫱᮲௳ࡣࠊᐇ㦂ື≀Ꮫⓗ࡟ࡣࡶ࡜ࡼࡾࠊື≀⚟♴
ࡢ㠃࠿ࡽࡶ㐺ษ࡞ࡶࡢ࡛࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ᪋⪅ཬࡧᐇ㦂ື≀⟶⌮⪅ࡣࠊ༠ຊࡋ࡚㐺ษ࡞᪋タ࣭タഛࡢ⥔ᣢ⟶⌮࡟ດࡵࡿ
࡜࡜ࡶ࡟ࠊᐇ㦂ື≀࡬ࡢ㐺ษ࡞⤥㣵ཬࡧ⤥Ỉ➼ࡢ㣫⫱⟶⌮ࢆ⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞
࠸ࠋ
㸱㸬ᐇ᪋⪅ཬࡧᐇ㦂ື≀⟶⌮⪅ࡣࠊ༠ຊࡋ࡚ᐇ㦂ື≀ࡢᑟධ᫬࠿ࡽᐇ㦂⤊஢᫬࡟࠸
ࡓࡿࡍ࡭࡚ࡢᮇ㛫࡟ࢃࡓࡗ࡚ࠊᐇ㦂ື≀ࡢ≧ែࢆ௘⣽࡟ほᐹࡋࠊ㐺ษ࡞ฎ⨨ࢆ᪋
ࡉ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
ϯ ᐇ㦂᧯స
㸯㸬ື≀ᐇ㦂ࡣࠊᩚഛࡢ⾜ࡁᒆ࠸ࡓᑓ⏝༊ᇦෆ࡛⾜ࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ᪋⪅ࡣࠊື≀⚟♴ࡢほⅬ࠿ࡽࠊ㯞㓉➼ࡢᡭẁ࡟ࡼࡗ࡚ᐇ㦂ື≀࡟↓⏝࡞ⱞ③
ࢆ୚࠼࡞࠸ࡼ࠺㓄៖ࡋࠊేࡏ࡚㐺ษ࡞ಖᐃࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ
㸱㸬ᐇ᪋⪅ࡣࠊᚲせ࡟ᛂࡌ࡚ࠊᐇ㦂ື≀⟶⌮⪅ⱝࡋࡃࡣᐇ㦂ື≀ࡢᑓ㛛ᐙཪࡣጤဨ
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఍࡟ᣦᑟཬࡧุ᩿ࢆồࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸
ϰ ᐇ㦂⤊஢ᚋࡢฎ⨨
㸯㸬ᐇ᪋⪅ࡣࠊᐇ㦂ࢆ⤊஢ࡋࡓື≀ࡢฎ⨨࡟ᙜࡓࡾࠊ⮴Ṛ㔞௨ୖࡢ㯞㓉⸆ࡢᢞ୚ࡑ
ࡢ௚㐺ษ࡞᪉ἲ࡟ࡼࡗ࡚ࠊ㏿ࡸ࠿࡟ᐇ㦂ື≀ࢆⱞ③࠿ࡽ㛤ᨺࡉࡏࡿࡼ࠺ດࡵ࡞ࡅ
ࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ࡢṚయࠊᝏ⮯ཬࡧ⣅ᒀ➼࡟ࡼࡗ࡚ࠊேࡢ೺ᗣཬࡧ⏕ά⎔ቃ
ࡀᦆ࡞ࢃࢀ࡞࠸ࡼ࠺࡟ດࡵ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
ϱ Ᏻ඲⟶⌮➼࡟≉࡟ὀពࢆᡶ࠺ᚲせࡢ࠶ࡿᐇ㦂
㸯㸬ື≀ᐇ㦂㈐௵⪅ࡣࠊ≀⌮ⓗⱝࡋࡃࡣ໬Ꮫⓗ࡟༴㝤࡞≀㉁ཪࡣ⑓ཎయ➼ࢆᢅ࠺ື
≀ᐇ㦂ࡢᐇ᪋࡟ᙜࡓࡾࠊேࡢᏳ඲ࢆ☜ಖࡍࡿࡇ࡜ࡣࡶ࡜ࡼࡾࠊ㣫⫱⎔ቃࡢởᰁ࡟
ࡼࡾᐇ㦂ື≀ࡀ㞀ᐖࢆཷࡅࠊཪࡣᐇ㦂ᡂ⦼ࡢಙ㢗ᛶࡀᦆ࡞ࢃࢀࡿࡇ࡜ࡢ࡞࠸ࡼ࠺ࠊ
༑ศ࡟㓄៖ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋࡲࡓࠊ᪋タࡢ࿘ᅖࡢởᰁ㜵Ṇ࡟ࡘ࠸࡚ࡣࠊ≉࡟
ὀពࢆᡶࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸰㸬ᐇ㦂ᐇ᪋⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࠊࡇࡢᣦ㔪ࢆ㑂Ᏺࡍࡿ࡜࡜ࡶ࡟ࠊ㛵㐃ࡍࡿㅖ
ἲ௧ཬࡧ㝔ෆつ⛬➼࡟ᚑࢃ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸱㸬ᐇ᪋⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ື≀ࡀ⟶⌮༊ᇦ࠿ࡽ㐓㉮ࡋ࡞࠸ࡼ࠺ࠊ㐺ษ
࡞㏨ஸ㜵Ṇᥐ⨨ࢆㅮࡌ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ
㸲㸬ᐇ᪋⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࠊᐇ㦂ື≀ࡀ⟶⌮༊ᇦ࠿ࡽ㐓㉮ࡋࡓሙྜ࡟ࡣ┤ࡕ
࡟ᛂᛴᥐ⨨ࢆ࡜ࡾࠊ㛵㐃ᶵ㛵࡬㏿ࡸ࠿࡟㐃⤡ࡍࡿࡇ࡜ࠋ
㸳㸬ᆅ㟈࣭ⅆ⅏࡞࡝ࡢ⥭ᛴ᫬࡟࡜ࡿ࡭ࡁᥐ⨨࡟㛵ࡍࡿィ⏬ࢆ࠶ࡽ࠿ࡌࡵィ⏬ࡋ࡚࠾
ࡃࡇ࡜ࠋ
ϱϨ ᐇ㦂ࡢグ㘓࣭ಖᏑ➼
㸯㸬ᐇ㦂ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ࡢ㣫⫱࡟ᙜࡓࡗ࡚ࡣࠊ㣫⫱ື≀ࡢ඲ᩘࢆ௘యࡶྵࡵ࡚
ẖ㐌ィ ࡋࠊ㣫⫱ᩘ⟶⌮⡙࡟グ㘓ࡋ࡚ࠊᐇ㦂ື≀⟶⌮⪅࡟ሗ࿌ࡍࡿࡇ࡜ࠋ
㸰㸬ᐇ㦂ᐇ᪋⪅ࡣࠊసᴗ๓ᚋ࡟సᴗࡋࡓࢣ࣮ࢪࡈ࡜࡟ື≀ᩘኚ໬࡟ㄗࡾࡢ࡞࠸ࡇ࡜
ࢆィ ࣭グ㘓ࡍࡿࡇ࡜ࠋ
㸱㸬ᐇ㦂ᐇ᪋⪅ࡣࠊᐇ㦂ື≀ᐊࡢධ㏥ฟࢆ⟶⌮⡙࡟グ㘓ࡍࡿࡇ࡜ࠋ
㸲㸬㣫⫱ᩘ⟶⌮⡙ཬࡧධ㏥ฟ⟶⌮⡙ࡣࠊື≀ᐇ㦂ጤဨ఍୪ࡧ࡟㑇ఏᏊ⤌᥮࠼ᐇ㦂Ᏻ
඲ጤဨ఍࡟ᐃᮇⓗ࡟ᥦฟࡋࠊᑂᰝࢆཷࡅࡿࡇ࡜ࠋ
ϱϩ ᩍ⫱࣭⮬ᕫⅬ᳨
㸯㸬⟶⌮⪅ࡣࠊᐇ㦂ື≀ࡢ౑⏝➼࡟ᚲせ࡞ἲ௧࣭సᴗᡭ㡰࡟㛵ࡍࡿᩍ⫱࣭カ⦎ࢆᖺ
㸯ᅇ⛬ᗘ㛤ദࡋࠊ◊✲ᐊ㛗ࠊᐇ㦂ᐇ᪋⪅ཬࡧື≀ᐇ㦂㈐௵⪅ࡣࡇࢀ࡟ཧຍࡍࡿࡇ
࡜ࠋ
㸰㸬ື≀ᐇ㦂ጤဨ఍ࡣࠊᐇ㦂ື≀ࡢ౑⏝᪋タ࡟ᑐࡋᣑᩓ㜵Ṇᥐ⨨ࢳ࢙ࢵࢡࣜࢫࢺ࡟
ࡼࡿᖺ ᅇࡢ⮬ᕫⅬ᳨ࢆᐇ᪋ࡋࠊᅜ❧⑓㝔ᶵᵓᮏ㒊⥲ྜ◊✲ࢭࣥࢱ࣮࡬ࢳ࢙ࢵࢡ
― 253 ―
ࣜࢫࢺࢆᥦฟࡍࡿࡇ࡜ࠋ
㸱㸬⮬ᕫⅬ᳨࣭ホ౯ཬࡧ᳨ドࡢ⤖ᯝ➼࡟㛵ࡍࡿ᝟ሗࡣࠊẖᖺ㸯ᅇ⛬ᗘබ⾲ࡍࡿࡶࡢ
࡜ࡍࡿࠋ
ϱϪ ⿵๎
ࡇࡢᣦ㔪࡟ᐃࡵࡿࡶࡢࡢ࡯࠿ࠊື≀ᐇ㦂ࡢᐇ᪋࡟㛵ࡋᚲせ࡞஦㡯ࡣࠊጤဨ఍ࡢ㆟
ࢆ⤒࡚㝔㛗ࡀᐃࡵࡿࠋ
㝃 ๎㸦ᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥ᨵṇ㸧
㸦᪋⾜ᮇ᪥㸧
ࡇࡢᣦ㔪ࡣࠊᖹᡂ㸰㸲ᖺ㸲᭶㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
㸦つᐃࡢᗫṆ㸧
ࡇࡢᣦ㔪ࡢ᪋⾜࡟ేࡏ࡚ࠊḟ࡟ᥭࡆࡿᚑ๓ࡢᣦ㔪ࡣᗫṆࡍࡿࠋ
ᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮ື≀ᐇ㦂ᣦ㔪㸦ᖹᡂ㸯㸴ᖺ㸲᭶᪋⾜㸧
― 254 ―
㻌
㻌
㻌
㻌
䊥㻌 ⮫ᗋ◊✲䝉䞁䝍䞊ධ㒊䞉㏥㒊௚ᡭ⥆᭩㢮㻌
㻌
ὀ㻌 㻌 ᮾி་⒪䝉䞁䝍䞊ෆ䛚䜘䜃እ㒊䛾◊✲⪅䛜䝉䞁䝍䞊◊✲ဨ䛸䛧䛶
Ⓩ㘓䛩䜛䛯䜑䛾ᡭ⥆᭩㢮㻌
ᖹᡂ㸰㸳ᖺ㸯㸰᭶㸯㸯᪥つ⛬➨㸯㸮㸶ྕ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮◊✲ဨධ㒊⥘㡿
㸦┠ⓗ㸧
➨㸯᮲ ࡇࡢ⥘㡿ࡣࠊᮾி་⒪ࢭࣥࢱ࣮⮫ᗋ◊✲ࢭࣥࢱ࣮㸦௨ୗࠕឤぬჾࢭࣥࢱ࣮ࠖ࡜࠸
࠺ࠋ
㸧࡟᥇⏝ࡉࢀࡓ◊✲ဨࢆ㐺ṇ࡟⟶⌮ࡋࠊ෇⁥࡞ឤぬჾࢭࣥࢱ࣮ࡢ㐠Ⴀࢆᅗࡿࡓࡵ࡟ࠊ
◊✲ဨࡢ◊✲┠ⓗࠊ◊✲ᮇ㛫ཬࡧᮏேᒚṔ➼⟶⌮࡟ᚲせ࡞஦㡯ࢆᐃࡵࡿࡶࡢ࡜ࡍࡿࠋ
㸦ᚲせ᭩㢮㸧
➨㸰᮲ ධ㒊ཬࡧ㏥㒊࡟ᚲせ࡞᭩㢮ࡣࠊḟࡢྛྕࡢ࡜࠾ࡾ࡜ࡍࡿࠋࡲࡓࠊ᭩㢮ࡣ㐜࡞ࡃ
ᚲࡎᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋ
୍ ⮫ᗋ◊✲ࢭࣥࢱ࣮ධ㒊⏦㎸᭩㸦ᵝᘧ㸯㸧
஧ ㄋ⣙᭩㸦ᵝᘧ㸰㸧
୕ ᒚṔ᭩㸦ᵝᘧ㸱㸧
ᅄ ⮫ᗋ◊✲ࢭࣥࢱ࣮ධ㒊⏦㎸᭩㸦⸆๣ᖌࠊ┳ㆤᖌࠊ஦ົࠊࡑࡢ௚㸧㸦ᵝᘧ㸲㸧
஬ ㏥㒊㢪㸦ᵝᘧ㸳㸧
㸦ྡ⡙ཬࡧ㓄⨨ᅗ㸧
➨㸱᮲ ⮫ᗋ◊✲ࢭࣥࢱ࣮஦ົᐊࡣࠊ᪂ࡓ࡟◊✲ဨࢆධ㒊ࡉࡏࡓሙྜࠊឤぬჾࢭࣥࢱ࣮ྡ
⡙ཬࡧ㓄⨨ᅗ࡟グ㍕ࡋࠊ㸯ࣨ᭶ẖ࡟సᡂࡍࡿࠋ
㸦ಖ⟶㸧
➨㸲᮲ ➨㸰᮲࡟つᐃࡍࡿ᭩㢮࡟ࡘ࠸࡚ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮஦ົᐊ࡛ಖ⟶ࡍࡿࠋ࡞࠾ࠊ
ಖ⟶ᮇ㛫ࡣ◊✲ဨࡈ࡜࡟㏥㒊ᚋ㸳ᖺ㛫࡜ࡍࡿࠋ
㸦◊✲ᮇ㛫㸧
➨㸳᮲ ཎ๎࡜ࡋ࡚ධ㒊᫬Ⅼ࡟࠾࠸࡚◊✲ᮇ㛫ࢆᐃࡵࡿࡇ࡜࡜ࡍࡿࠋ
㸰 ◊✲ᮇ㛫ࡀᐃࡵࡽࢀ࡞࠸ሙྜ࡟࠾࠸࡚ࡶධ㒊ࢆチྍ࡛ࡁࡿࡀࠊࡑࡢሙྜ࡛ࡶ㸱ᖺ㛫ࢆ
㝈ᗘ࡜ࡍࡿࠋ
㸱 ◊✲ࢆ⥅⥆ࡍࡿሙྜࡣࠊධ㒊⏦㎸᭩㸦⥅⥆㸧ࢆᥦฟࡍࡿࠋ࡞࠾ࠊࡑࡢሙྜ࡟ࡣ➨㸰᮲
➨㸱ྕ࡟ᐃࡵࡿᒚṔ᭩ࢆ┬␎ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
㸲 ᭶ࡢ㏵୰࡟ධ㒊ࡋࡓሙྜࡣࠊᙜヱ᭶ࡢึ᪥ࢆ㉳⟬᪥࡜ࡍࡿࠋࡑࡢࡓࡵࠊ➨㸰㡯ࡢつᐃ
࡟ࡼࡾ◊✲ᮇ㛫ࡀ㸱ᖺ㛫࡜࡞ࡗࡓሙྜ࡟ࡣࠊධ㒊ࡋࡓ᪥ࡢ㸱ᖺᚋࡢ๓᭶ᮎ᪥ࢆࡶࡗ࡚ᮇ
㛫‶஢࡜ࡍࡿࠋ
㸳 ᮾி་⒪ࢭࣥࢱ࣮ࢆ㏥⫋ࡋࡓሙྜ࡟ࡣࠊ㏥㒊ࡋࡓࡇ࡜࡜ࡍࡿࠋࡑࡢሙྜ࡟ࡣࠊ➨㸰᮲
➨㸳ྕ࡟ᐃࡵࡿ㏥㒊㢪ࡣ┬␎ࡍࡿࡇ࡜ࡀฟ᮶ࡿࠋ
㸦⫋ဨࡢධ㒊㸧
➨㸴᮲ ᮾி་⒪ࢭࣥࢱ࣮ࡢ⫋ဨࡀධ㒊ࡍࡿ㝿ࡣࠊ➨㸰᮲➨㸯ྕࡲࡓࡣ➨㸲ྕ࡟ᐃࡵࡿධ
㒊⏦㎸᭩ཬࡧ➨㸰ྕ࡟ᐃࡵࡿㄋ⣙᭩ࡢࡳ࡜ࡍࡿࠋ
㸦ࡑࡢ௚㸧
➨㸵᮲ ࡇࡢ⥘㡿࡟ᐃࡵࡿࡶࡢࡢ࡯࠿ࠊࡇࡢ⥘㡿ࡢᐇ᪋࡟ᙜࡓࡾᚲせ࡞஦㡯ࡣ⮫ᗋ◊✲ࢭ
ࣥࢱ࣮㛗ࡀู࡟ᐃࡵࡿࡇ࡜ࡀ࡛ࡁࡿࠋ
― 255 ―
㝃 ๎
㸦᪋⾜ᮇ᪥㸧
ࡇࡢ⥘㡿ࡣࠊᖹᡂ㸰㸳ᖺ㸯㸰᭶㸯㸯᪥࠿ࡽ᪋⾜ࡍࡿࠋ
― 256 ―
⮫ᗋ◊✲
ࢭࣥࢱ࣮
஦ົྲྀᢅ
ෆ ⏦ ᭩
ูῧࠊධ㒊⏦㎸᭩ࡢ ࡣࠊ⮫ᗋ◊✲ࢭࣥࢱ࣮ဨ࡜ࡋ࡚㐺௵⪅࡜ㄆ
ࡵࠊ᥇⏝᪉ෆ⏦⮴ࡋࡲࡍࠋ
ᖹᡂ ᖺ ᭶ ᪥
㒊 㛗 ༳
― 257 ―
㸦ᵝᘧ㸯㸧
⮫ᗋ◊✲ࢭࣥࢱ࣮ධ㒊⏦㎸᭩ 㸦 ᪂つ ࣭ ⥅⥆ 㸧
ͤ‫ࢆۑ‬௜ࡅ࡚ࡃࡔࡉ࠸
⏦ㄳ᪥㸸ᖹᡂ ᖺ ᭶ ᪥
㸯㸬⏦ㄳ⪅
㸰㸬⏕ᖺ᭶᪥
㸱㸬ᡤᒓ᪋タ
㸲㸬ᚑ஦⫋ྡ
㸳㸬Ꮫ Ṕ
㸴㸬་ᖌචチ
㸵㸬◊✲ㄢ㢟ྡ
㸶㸬◊✲ᮇ㛫
Ặྡ ༳
㸦 ⏨ ࣭ ዪ 㸧
ఫᡤ
㸯㸷 ᖺ ᭶ ᪥ 㸦‶ ṓ㸧
᪋タྡ
ᡤᅾᆅ
᭱⤊༞ᴗᏛᰯྡ
༞ᴗᖺ᭶᪥ ᖺ
Ⓩ㘓ᖺ᭶᪥ ᖺ
Ⓩ㘓␒ྕ
⮬ ᖹᡂ ᖺ ⮳ ᖹᡂ ᖺ ᭶ ᪥
᭶ ᪥
᭶ ᪥
᭶ ᪥
㸷 㸬 ධ 㒊 ᕼ ᮃ
㒊
ᐊ
◊✲㒊
㸯㸮 ⫋ ✀
‫✲◊ ڧ‬ဨ ‫✲◊ ڧ‬ຓᡭཬࡧᢏ⾡ဨ
‫⮫ ڧ‬ᗋ་ᖌ ‫ ڧ‬እ㒊◊✲ဨ㸦ᖖ໅ࡢ᪋タ࣭⫋✀㸧
‫ࡢࡑ ڧ‬௚ 㸦 㸧
㸯㸯㸬ῧ௜㈨ᩱ 㸦㸯㸧ㄋ⣙᭩
㸦㸰㸧ᒚṔ᭩
㸦㸱㸧◊✲ィ⏬᭩
― 258 ―
㸦ᵝᘧ㸰㸧
ㄋ ⣙ ᭩
ᖹᡂ ᖺ ᭶ ᪥
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓ
ᮾி་⒪ࢭࣥࢱ࣮㝔㛗 Ẋ
◊✲⪅Ặྡ ༳
⚾ࡣࠊ௒ᅇࠊ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮࡟࠾ࡅࡿ◊✲࡟ࡘ࠸࡚ࡣࠊୗグ
ᮇ㛫୰ࠊἲ௧ཬࡧㅖつ๎ࢆ㑂Ᏺࡋ࡚◊✲ࡍࡿࡇ࡜ࢆㄋ⣙࠸ࡓࡋࡲࡍࠋ୙ṇࢆ⾜ࡗࡓሙྜࡣࠊ
ᶵ㛵ࡸ㓄ศᶵ㛵ࡢฎศཬࡧἲⓗ࡞㈐௵ࢆ㈇࠺஦ࢆేࡏ࡚ㄋ⣙࠸ࡓࡋࡲࡍࠋ
グ
◊✲ᮇ㛫 㸸 ⮬ ᖹᡂ ᖺ ᭶ ᪥
⮳ ᖹᡂ ᖺ ᭶ ᪥
― 259 ―
― 260 ―
㸦ᵝᘧ 㸧
⮫ᗋ◊✲ࢭࣥࢱ࣮ධ㒊⏦㎸᭩
㸦 ⸆๣ᖌ ࣭ ┳ㆤᖌ ࣭ ஦ົ ࣭ ࡑࡢ௚ 㸧
ͤ‫࠸ࡉࡔࡃ࡚ࡅࡘࢆۑ‬
⏦ㄳ᪥㸸ᖹᡂ ᖺ ᭶ ᪥
㸯 Ặ ྡ
༳
㸦 ⏨ ࣭ ዪ 㸧
㸰 ⏕ᖺ᭶᪥
㸯㸷 ᖺ ᭶ ᪥ 㸦‶ ṓ㸧
㸱 ᡤᒓ◊✲㒊
㒊
㸲 ᡤᒓ◊✲ᐊ
ᐊ 㸳 ෆ⥺␒ྕ
㸴(PDLO
㸵㸬༊ ศ
‫ڧ‬㠀ᖖ໅ ‫ ڧ‬ὴ㐵 ‫ࡢࡑ ڧ‬௚㸦 㸧
㸶㸬᥇⏝᪥
ᖹᡂ ᖺ ᭶ ᪥
㸷 ໅ົ᫬㛫
᭶᭙᪥
ⅆ᭙᪥
Ỉ᭙᪥
ᮌ᭙᪥
㔠᭙᪥
㹼
㹼
㹼
㹼
㹼
ͤ㏥⫋ࡢ㝿࡟ࡣᚲࡎࠕ㏥㒊ᒆࠖࢆࡈᥦฟࡃࡔࡉ࠸ࠋ
ͤ໅ົ᫬㛫࣭᭙᪥ࡢኚ᭦ࡢ㝿࡟ࡣ஦ົᐊࡲ࡛࠾ᒆࡅࡃࡔࡉ࠸ࠋ
― 261 ―
㸦ᵝᘧ 㸧
㏥ 㒊 㢪
ࡇࡢࡓࡧ ࡟ࡼࡾ
ᖹᡂ ᖺ ᭶ ᪥௜㏥㒊࠸ࡓࡋࡓ࠸ࡢ࡛ࡈᢎㄆ㢪࠸ࡲࡍࠋ
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓ
ᮾி་⒪ࢭࣥࢱ࣮
⮫ᗋ◊✲ࢭࣥࢱ࣮㛗 Ẋ
ᖹᡂ ᖺ ᭶ ᪥
⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪ࢭࣥࢱ࣮
⮫ᗋ◊✲ࢭࣥࢱ࣮ ᡤᒓ㒊ྡ ᡤᒓᐊྡ Ặ ྡ ༳
㸦஦ົ౑⏝ḍ㸧
㘽 ㏉༷
㌟ศド᫂᭩㏉༷
― 262 ―
ࢭࣥࢱ࣮ㅮᖌᐟἩ᪋タ฼⏝ᡭ㡰
ᇶᮏ㸸ᐟἩ⪅࡟㛵ಀࡍࡿྛ◊✲㒊ࡀ㈐௵ࢆᣢࡗ࡚
ୗグࡢ࣮ࣝࣝ࡟ᚑࡗ࡚ᑐᛂࡍࡿࡇ࡜ࢆཎ๎࡜ࡍࡿࠋ
㸯㸬฼⏝チྍ⏦ㄳ᭩ࢆ 㝵஦ົᐊ࡟ᥦฟ㸦Ѝ 㝵஦ົᐊಖ⟶㸧ࠋ
㸰㸬⏦ㄳ᭩ᥦฟ᫬࡟ 㝵஦ົᐊ࡟࡚ㅮᖌᐊᐟἩグ㘓ࣀ࣮ࢺ࡟ᚲせ஦㡯グධࠋ
㸱㸬⏦ㄳ⪅࠶ࡿ࠸ࡣ฼⏝⪅ࡀࣜࢿࣥᐊࣇࣛࣥࢫ࣋ࢵࢺෆ⥺㸱㸮㸱㸮࡟㟁ヰࡋࠊ
ࠕ⮫ᗋ◊✲ࢭࣥࢱ࣮ࡢㅮᖌᐟἩᐊ࡟౑࠺ࡢ࡛ᕸᅋࢆ୍ᘧ㈚ࡋ࡚ୗࡉ࠸ࠖ࡜ఏ࠼ࠊ
೉⏝᪥᫬ࠊ㏉༷᪥᫬ࢆᡴࡕྜࢃࡏࠊྲྀࡾ࡟⾜ࡃࠋ
㸲㸬ㅮᖌᐊࡢ㘽ࢆ 㝵஦ົᐊ࠿ࡽ೉ࡾࡿࠋ
㸳㸬ᐟἩᚋࠊᕸᅋ㏉༷࣭Ύᤲࠋ
㸴㸬 㝵஦ົᐊ࡟㘽ࢆ㏉ࡍࠋ
㸨Ὑ㠃⏝ල➼ᾘ⪖ရࡣྛ⮬࡛ࡈ⏝ពࡃࡔࡉ࠸ࠋ㸦㒊ᒇ࡟⨨ࡁࡗࡥ࡞ࡋ୙ྍ㸧
㸨Ύᤲ≧ἣ୙᭹ࡢሙྜࡣᐟἩグ㘓ࣀ࣮ࢺࢆぢ࡚ྛ⮬㐃⤡ࢆྲྀࡾྜࡗ࡚ୗࡉ࠸ࠋ
㸨ᅵ᪥ࡣ 㝵஦ົᐊࡣఇࡳࡢⅭࠊ㘽ࡢ㏉༷ࡀᅵ᪥ࡢሙྜࠊ㛵ಀࡍࡿ◊✲㒊ࡀ㈐௵ࢆ
ᣢࡗ࡚ཷࡅྲྀࡾࠊ㐌᫂ࡅ࡟ 㝵஦ົᐊ࡟㏉༷ࡢࡇ࡜
ࡇࡢ฼⏝ᡭ㡰ࡣࠊᖹᡂ ᖺ ᭶ ᪥ࡼࡾ᪋⾜ࡍࡿࠋ
ᮾி་⒪ࢭࣥࢱ࣮ ⮫ᗋ◊✲ࢭࣥࢱ࣮
ࢭࣥࢱ࣮㛗 ຍᡃ ྩᏕ
― 263 ―
⦅㞟ᚋグ
ᖹᡂ ᖺᗘࡣ඲యࡢάື࡟஧ࡘࡢ኱ࡁ࡞ฟ᮶஦ࡀ࠶ࡾࡲࡋࡓࠋ୍ࡘࡣ ᖺ ᭶ ᪥࡟㛤ദࡉࢀࡓ
➨ ᅇឤぬჾࢩ࣏ࣥࢪ࣒࡛࢘ࠊᕷẸබ㛤ㅮᗙࢆවࡡࡓ௒ᅇࡢ≉㞟ࡢࢸ࣮࣐ࡣࠕ㧗㱋⪅࡜་⒪ ࢧࢡࢭࢫ
ࣇ࣭࢚ࣝ࢖ࢪࣥࢢ࡬ࡢᣮᡓ࡛ࠖ ྡࡢࢩ࣏ࣥࢪࢫࢺ࡟ࡼࡿㅮ₇ࡣ኱ࡁ࡞཯㡪ࡀ࠶ࡾࡲࡋࡓࠋ࣏ࢫࢱ࣮ࡢ
ࢹࢨ࢖ࣥࡣ *UDSKLF'HVLJQ5RRP ͆)͇࡟౫㢗ࡋ࢖ࣥࣃࢡࢺࡢ࠶ࡿࡶࡢ࡜࡞ࡾࡲࡋࡓࠋࡶ࠺୍ࡘࡣᮾி
་⒪ࢭࣥࢱ࣮๰❧ ࿘ᖺグᛕᘧ඾࡜⚃㈡఍࡛ᖹᡂ ᖺ ᭶ ᪥࡟㛤ദࡉࢀࡲࡋࡓࠋᮾி་⒪ࢭࣥࢱ
࣮ࡢ๓㌟ࡣᅜ❧➨஧⑓㝔࡛ࠊྂ࠸ᮌ㐀ࡢ⑓㝔࡛࠶ࡗࡓ᫬௦ࠊ་ᖌᅜᐙヨ㦂ࡢ㠃᥋ࢆཷࡅ࡟᮶ࡲࡋࡓࡀࠊྂ
ࡃᬯ࠸༳㇟࡛ࠊࡓࡃࡉࢇࡢᶞᮌ࡟ᅖࡲࢀ࡚࠸ࡲࡋࡓࠋ⌧ᅾࡢᮾி་⒪ࢭࣥࢱ࣮ࡣྛᆅ࠿ࡽゼࢀࡿᝈ⪅ࡢ
ⓙᵝࡀ࣍ࢵ࡜ࡍࡿࡼ࠺࡞ⓑளࡢ⑓㝔࡛ࡍࠋ㥖ἑ࢜ࣜࣥࣆࢵࢡබᅬࡢ୍㒊࡟࠶ࡿࡼ࠺࡞༳㇟ࢆ୚࠼࡚ࡃࢀ
ࡲࡍࠋ ᖺࡢᅄᏘࢆ᣺ࡾ㏉ࡾࡲࡍ࡜ࠊࢭࣥࢱ࣮ࡢ࿘ᅖࡣ ᭶ࡢ⨾ࡋ࠸⣚ᱵࠊ ᭶ࡢᱜࠊ ᭶ࡢࢶࢶࢪࠊኟ
ࡢ㖟ᮥࡢ኱ᮌࡢ⥳ࠊࡦࡲࢃࡾࠊ⛅ࡢ⣚ⴥ࡜࡝ࡢᏘ⠇ࡶᮾி࡛࠶ࡾ࡞ࡀࡽ⮬↛ࡢኚ໬ࢆᴦࡋࡲࡏ࡚ࡃࢀࡲ
ࡍࠋ᪂ࡋࡃࣄ࣏ࢡࣛࢸࢫࡢᮌ㸦㕥ᠱࡢᮌ㸧ࡀ ᖺ᫓ࡼࡾຍࢃࡾࡲࡋࡓࠋ๓⑓㝔㛗ࡢᯇᮏ⣧ኵඛ⏕ࡢ㏥
௵グᛕ࡟᳜ᶞࡉࢀࡓࡶࡢ࡛ࡍࠋ
⮫ᗋ◊✲ࢭࣥࢱ࣮㸦ឤぬჾࢭࣥࢱ࣮㸧ࡢྡ⛠ࡀࢭࣥࢱ࣮఍㆟࡛㆟ㄽࡉࢀࡲࡋࡓࠋᮾி་⒪ࢭࣥࢱ࣮ࡢ⮫
ᗋ◊✲ࢭࣥࢱ࣮ࡣ᫖ᖺᛴ㏽ࡉࢀࡓᒸᮏ೺ඛ⏕ࡀ⑓㝔㛗ࡢ㡭ࠊࡈᮏேࡀᜍࡽࡃᚚ㧗ྡ࡞⫈ぬ◊✲⪅࡛࠶ࡗ
ࡓࡇ࡜ࡶ࠶ࡾឤぬჾ◊✲ࡀ㔜どࡉࢀࡲࡋࡓࠋ⌧ᅾࡢ⮫ᗋ◊✲ࢭࣥࢱ࣮ࡀㄌ⏕ࡋࡓ᫬ࡣࠊᑗ᮶ࡢᅜ❧ឤぬ
ჾ◊✲ࢭࣥࢱ࣮࡬Ⓨᒎࡉࡏࡿࡇ࡜ࢆ┠ᣦࡋࠊ⌧ᅾ࡛ࡶࡑࡢ⪃࠼ࡀᗏὶ࡟࠶ࡾࠊ᪥ᮏ║⛉Ꮫ఍࡜᪥ᮏ⪥㰯
ဗႃ⛉Ꮫ఍ࡀ኱ࡁ࡞ᨭ᥼ࢆࡋ࡚ࡁࡲࡋࡓࠋᾏእ࡬Ⓨಙࡍࡿ◊✲ㄽᩥࡣ 1DWLRQDO ,QVWLWXWH RI 6HQVRU\
2UJDQVࠊ␎⛠ 1,62 ࡟ࡣࡇࡢࡼ࠺࡞Ṕྐⓗ⫼ᬒࡀ࠶ࡾࡲࡍࠋ
᭱㏆࡛ࡣ◊✲άື࡟ྲྀࡾ⤌ࡴ࡟ࡣከࡃࡢ㛵ᡤࢆ⤒࡞ࡅࢀࡤ㐍ࡵࡽࢀ࡞࠸ࡼ࠺࡞ࢤ࣮ࢺࡀ⏝ពࡉࢀ࡚࠸ࡲ
ࡍࠋඹྠ◊✲⪅࡛◊✲ဨ࡛ࡣ࠶ࡾࡲࡍࡀ௚ࡢ᪋タ࡛௙஦ࢆࡋ࡚࠾ࡽࢀ࡚ࡶࠊᮾி་⒪ࢭࣥࢱ࣮ࡢࢤ࣮ࢺࢆ
✺◚ࡍࡿᚲせࡀ࠶ࡾࠊྛ◊✲⌜ࡢඛ⏕ࡀఏ࠼ࡿᚲせࡀ࠶ࡾࡲࡍࠋ
⮫ᗋ◊✲ࢭࣥࢱ࣮࡟ࡣ◊✲άືࢆᨭ࠼ࡿ⣙ ྡࡢ⛎᭩ࡢⓙࡉࢇࡀᅾ⫋ࡋᨭ࠼࡚ࡃࢀ࡚࠸ࡲࡍࠋ኱Ꮫࡢ
ᩍᐊ୪ࡢⓙࡉࢇࡀά㌍ࡋ࡚࠸ࡲࡍࠋ
⟶⌮Ჷ 㝵ࡢ⮫ᗋ◊✲ࢭࣥࢱ࣮ࡢ஦ົᐊࡢྜྷᕝளᕼࡉࢇ࡜ቑ⏣▱ᐇࡉࢇࡣ࣋ࢸࣛࣥࡢ⛎᭩ࡢⓙࡉࢇࡢ
୰࡛ࡍࡗ࠿ࡾᯈ࡟ࡘ࠸࡚ࢫ࣒࣮ࢬ࡟㐠Ⴀࡉࢀ࡚࠸ࡿࡇ࡜࡟ᚚ♩ࢆ⏦ࡋୖࡆࡲࡍࠋ
ྡ㄃⮫ᗋ◊✲ࢭࣥࢱ࣮㛗 ຍᡃ ྩᏕ
― 265 ―
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⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓᮾி་⒪䝉䞁䝍䞊⮫ᗋ◊✲䝉䞁䝍䞊㻌
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㻞㻜㻝㻢 ᖺ 㻤 ᭶Ⓨ⾜㻌
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Ⓨ⾜㻌 㻌 㻌 ⊂❧⾜ᨻἲேᅜ❧⑓㝔ᶵᵓ㻌
ᮾி་⒪䝉䞁䝍䞊㻌
⮫ᗋ◊✲䝉䞁䝍䞊㻌
䛈㻝㻡㻞㻙㻤㻥㻜㻞㻌
ᮾி㒔┠㯮༊ᮾ䛜ୣ䠎䠉䠑䠉䠍㻌
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