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一括ダウンロード

日本大学学術研究戦略プロジェクト
日本大学 N. 研究プロジェクト
ナノ物質を基盤とする光・量子技術の極限追求
平成 21 年度−平成 25 年度
平成 24 年度報告書
研究代表者：大月穣（日本大学理工学部教授）
Nihon University Strategic Projects for Academic Research
Nanotechnology Excellence, Nihon University
— Nanomaterial-based Photonic, Quantum and Bio Technologies —
2009 㧙 2013
Progress Report 2012
Principal Investigator: OTSUKI, Joe
Professor of College of Science and Technology, Nihon University
日本大学 N. 研究プロジェクト発行物第 12 号
http://www.nihon-u.ac.jp/research/n_research_project/project01/Nproject21.html
目次 / Contents
健やか未来へ向けて……………………………………………………………………………………1
メンバー…………………………………………………………………………………………………2
研究課題要旨……………………………………………………………………………………………3
研究体制…………………………………………………………………………………………………3
研究目標…………………………………………………………………………………………………4
2012 年度の主な成果 …………………………………………………………………………………6
成果発信…………………………………………………………………………………………………9
活動記録 2012 年 2 月以降 ………………………………………………………………………… 10
班の報告……………………………………………………………………………………………… 11
研究者の報告………………………………………………………………………………………… 21
Toward a Healthy Future ………………………………………………………………………… 53
Researchers ………………………………………………………………………………………… 56
Overview of the Project …………………………………………………………………………… 57
Research Groups …………………………………………………………………………………… 57
Objectives of the Project ………………………………………………………………………… 58
Publications Records ……………………………………………………………………………… 60
Progress Reports of Groups ……………………………………………………………………… 61
Progress Reports of Individual Researchers ………………………………………………… 72
業績 / Publications and Achievements since 2012 ……………………………………………104
外部評価委員による評価 / Reviews by the Advisors …………………………………………125
参考資料 / Supplementary Materials since 2012 ……………………………………………129
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6 ~ 26 zÆÇ 7+9/4"0'9ÈÄSÊTÃ 4 ÁC³dÈDr. M. Sahabul Alam;
University of Dhaka, Bangladesh; Visiting Researcher of Nihon University, "Supramolecular
Nanoarchitectures — Novel Functional Materials for Molecular Electronics"
7 ~ 23 zÆ~Ç 7+9/4"0'9ÈÄSÊTÃ 4 ÁC³dÈDr. M. Sahabul Alam;
University of Dhaka, Bangladesh; Visiting Researcher of Nihon University, "Structural and
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Complexes"
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Department of Optical Science and Engineering, Fudan University, Shanghai,
China, ”Development of ellipsometry and its applications in nanoscale materials”
10 ~ 5 zÆ½Ç r¤Y"0'9È¬H¦x¢b"7#92 Á"0'9dÈYu-Xiang
Zheng vt; Key Laboratory of Micro and Nano Photonic Structures, Ministry of Education,
Department of Optical Science and Engineering, Fudan University, Shanghai, China,
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[1] T. Sako et al., J. Phys. B, 2012, 45, 235001(13 pages).
[2] T. Sako et al., Europhysics News, to appear in January issue (2013).
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[1] S. Matsushita, O. Suavet, H. Hashiba, Electrochim. Acta, 55 (2010) 2398-2403.
[2] A. Matsutani, M. Hayashi, Y. Morii, K. Nishioka, T. Isobe, A. Nakajima, S. Matsushita , Jpn. J.
Appl. Physics, 51 (2012) 098002.
[3] T. Miyamoto, S. Saito, T. Isobe, A. Nakajima, S. Matsushita, Chem. Commun., 48 (2012) 1668.
50
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51
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52
Nihon University N.Research Project 2012
Toward a Healthy Future
Almost four years have passed since we started our project “Nanotechnology Excellence, Nihon
University — Nanomaterial-based Photonic, Quantum and Bio Technologies —” in the strategic
research scheme of our university, “Nihon University N. Research Project.”
The purpose of our project is to contribute to finding solutions for three big issues — (1) treatment of
cancer, which accounts for a third of deaths in Japan, (2) shortage of fossil fuel and increase in the
atmospheric CO2 concentration, particularly after the Fukushima accident, and (3) dire need for
massive and secure information processing — for a healthy future comes true. Despite the apparent
diversity of these issues, views from nanoscience and nanotechnologies may allow a common
approach from different but relevant fields. Our approach to these issues is on the basis of
nanomaterials, particularly from the viewpoints of quantum mechanical interactions of matter with
light. This interdisciplinary endeavor is being made through collaboration among practitioners in
science, engineering, and medicine from five of the Colleges of Nihon University.
The first year saw some excellent achievements, such as one in the area of super-high speed recording,
which was covered as research topics in several journal articles, and another on the analysis of genetic
network, which was published in Nature (Nagase, Balmain et al., Nature 2009, 458, 505). The most
notable in the second year was the research on quantum information by Inoue et al. The three major
achievements were that: (1) the highest rate of 2.8 kilobit in the entanglement distribution at the
telecommunication wavelength to date, (2) the detection efficiency of 98.4% with their photonnumber resolving detector, the highest for an optical photon detector, and (3) the fabrication of the
first superconducting nanowire single photon detector using niobium film. One of these works was
published in Nature Photonics (Inoue et al., Nat. Photon. 2010, 4, 655.) and led to the successful
awarding of the Strategic Information and Communications R&D Promotion Program (SCOPE)
funded by the Ministry of Internal Affairs and Communications. In the third year, the highest rate (24
kbit/s) and the longest distance (100 km) quantum information transfer were achieved using the
highest-rate single-photon detector and the most sensitive photon-number resolving detector, which
were developed by Inoue and co-workers (Inoue et al., Phys. Rev. Lett. 2011, 106 250503). In the area
of super fast recording, behaviors of spins in a magnetic material in a femto second regime were
revealed for the first time (Tsukamoto, Itoh et al. Nature 2011, 472, 205).
In the fourth year, Tsukamoto et al. have found, surprisingly, that heat is enough to flip over the
magnetization in a work published in Nature Communications (Tsukamoto, Itoh et al., Nat. Commun.
2012, 3, 666). This is unconventional process given that heat is the antipodal to directionality. The
process occurs at room temperature, which bodes well for practical applications.
Ultrafast heating flips over the magnetization!
Nat. Commun. 2012, 3, 666.
In the energy area, greener alternatives are being researched that maximizes the use of solar energy as
an energy source and hydrogen as an energy storage material. Stored energy as hydrogen may again be
converted to electricity with fuel cells. Solid oxide fuel cell consists of three major components: the
fuel electrode, the electrolyte, and the air electrode. Hashimoto et al. (J. Amer. Ceram. Soc. 2012, 95,
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Nihon University N.Research Project 2012
3802) has developed the optimized material for each of these phases: a material for the fuel electrode,
Fabrication and performance tests for prototypical fuel cells using these materials are ongoing.
Optimized material for the electrode in fuel cells. J. Amer. Ceram. Soc. 2012, 95, 3802.
In the medical area, our research on pyrrole-imidazole polyamides, a class of synthetic compounds
that can be tailor-made to selectively recognize the base sequences in DNA, covers a whole range
from the synthesis and chemical characterization to in vitro and in vivo studies. Some PI polyamides
showed positive results in retarding the growth of osteosarcoma cells, hepatoblastoma cells, and
Wilm's tumor cells. Investigation on other PI polyamides has progressed further and now reached the
stage of marmosets experiments, which are conducted in collaboration with the Central Institute for
Experimental Animals. Preliminary results suggested that the drug is effective in the inhibition of the
skin scar. In the area of regenerative medicine, Fukuda et al. are attempting to induce iPS cells by
using PI polyamides which target TGF-1. Kano et al. is developing new pluripotent cells from fat
cells on the bases of his finding that fat cells can be dedifferentiated. In the environment of this
collaborative project, a new combination of technology and medicine is being formed. Application of
plasma for the treatment of skin malignant melanoma is now being examined.
A very basic quantum mechanical riddle was solved this year. The Hund rule, a textbook principle of
quantum mechanics, has concealed its origin for a long time until Sako et al. found the mechanism
behind the rule (Sako et al., J. Phys. B 2012, 45, 235001). The work was chosen as an "IOP Select"
paper for the novelty, significance and potential impact on future research. This work will also be
highlighted in Europhysics News.
Self-assembly of molecules leads to higher order structures and novel materials. Finding new motifs of
molecular assembly is important for the understanding how molecules assemble themselves and for
the development of new functional materials. Otsuki et al. found that synthetically modified
chlorophyll molecules form double stranded helices reminiscent of the DNA double helices. Work is
ongoing for revealing the structural requirements for the formation of such structures as well as
photophysical properties of these assemblies.
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Nihon University N.Research Project 2012
X-ray crystal structure of a double helix of synthetic chlorophyll molecules.
Training young generation researchers is another important objective of our project. This year 10
research fellows including post-doctoral fellows and 4 research assistants are working with financial
support from the Project. Good news is that 6 students who presented their works as part of the Project
were awarded excellent presentation prizes in academic meetings.
We are doing our best, through our research, to create a center of excellence in the field of
nanoscience and nanotechnology, which will hopefully be recognized as such in the scientific
communities academic and industrial, domestic and international, in another year when the Project
will have been completed.
Joe Otsuki, Principal Investigator, January 19, 2013.
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Nihon University N.Research Project 2012
Researchers
Osamu ABE
SM
Yasuo ASADA
CST
Tomohiko ASAI
CST
Shigeru CHAEN
CHS
Kyoko FUJIWARA
SM
Noboru FUKUDA
SM
Hideomi HASHIBA
CST
Takuya HASHIMOTO
CHS
Hiroki IKAKE
CST
Shuichiro INOUE
CST
Hiroshi ISHIDA
CHS
Akiyoshi ITOH
CST
Nobuyuki IWATA
CST
Ken JUDAI
CHS
Koichiro KANO
CBS
Tsugumichi KOSHINAGA
SM
Takeshi KUWAMOTO
CST
Yoshikazu MASUHIRO
CBS
Yoshiaki MATSUMOTO
CP
Sachiko MATSUSHITA
TITEC
Hiroki NAGASE
Chiba Cancer Center
Katsuji NAKAGAWA
CST
Nobuyuki NISHIMIYA
CST
Shinichiro OHNUKI
CST
Joe OTSUKI
CST
Tokuei SAKO
CST
Masayoshi SOMA
SM
Kaoru SUZUKI
CST
Satoru TAKAHASHI
SM
Yoshiki TAKANO
CST
Arata TSUKAMOTO
CST
Tsuneki YAMASAKI
CST
Advisory Board
Katsuhiko ARIGA
Allan BALMAIN
Masashi KIMURA
Jun MIYAKE
Isao SAITO
Ikuo SUEMUNE
Medical, Apr. 2012Energy
Nanomaterials and Nanodevices
Nanomaterials and Nanodevices
Medical, Sep.2010Medical*
Quantum Information; Nanomaterials and Nanodevices
Energy*, Nanomaterials and Nanodevices
Supramolecules and Self-Assembly*
Quantum Information*
Quantum Theory and Computation
Information Storage; Supramolecules and Self-Assembly
Nanomaterials and Nanodevices
Nanomaterials and Nanodevices
Medical
Medical, Sep.2009–
Quantum Information
Medical, Mar.2011–
Medical
Energy; Supramolecules and Self-Assembly
Medical
Information Storage *
Energy
Quantum Theory and Computation
Energy; Supramolecules and Self-Assembly
Quantum Theory and Computation*
Medical
Nanomaterials and Nanodevices*
Medical
Nanomaterials and Nanodevices
Information Storage; Supramolecules and Self-Assembly
Quantum Theory and Computation
NIMS
University of California, San Francisco
Nihon University
Osaka University
Nihon University
Hokkaido University
Nano
Medical
Publicity
Energy
General, Medicine
Information
The asterisks indicate the group leaders. CBS = College of Bioresource Sciences, CHS = College of
Humanities and Sciences, CP = College of Pharmacy, CST = College of Science and Technology, SM
= School of Medicine, TITEC=Tokyo Institute of Technology,
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Nihon University N.Research Project 2012
Overview of the Project
This project addresses three major issues that needs technological innovations:
- 1. Information technology: Super high speed, super high density recording and quantum
information processing
- 2. Energy technology: Solar energy harvesting with nanostructures
- 3. Medical technology: Nanobio technologies for medical applications
on the basis of our photonic, quantum, and bio technologies through collaborative studies over
different departments of Nihon University.
To establish a common basis for the research on the three subjects, this project also explores sciences
and technologies in
- Photonics and quantum aspects of nanomaterials.
Nanomaterials will be fabricated both from bottom-up approaches and top-down approaches as well as
by reactions controlled at the nanometer level. The experimental approaches are complemented by
quantum theoretical and computational studies on the interaction of light with matter at the nanometer
scale. Nanomaterials will be developed through these approaches for the applications in the above
mentioned three areas.
Thus this project aims at providing innovative technologies to contribute to realize a highly-developed
sustainable society. We also put an emphasis on education for young generations through the
interdisciplinary cutting-edge research.
Research Groups
The members belong to one or more groups depending on the area of research. Application oriented
groups mutually collaborate around the groups for nanoscience and nanotechnology.
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Nihon University N.Research Project 2012
Objectives of the Project
We conduct our research in groups for respective areas. The issues the groups will address are outlined
below. Specific goals are tabulated in Table 1 in the following page.
Information Technology Group
Super high speed, super high density recording and quantum information processing
This group attempts to make a breakthrough in writing and reading speed on the basis of the
photoinduced magnetization, a new physical phenomenon this group has found, in combination with
near-field optics and nanostructured magnetic materials prepared via self-assembly processes. The
group will also develop quantum information technologies aiming at super high capacity transmission
of information, super high speed computing, and super secure encryption. To be specific, the group
will develop (1) a single photon source, (2) a low-noise single photon detector, (3) a photon number
resolving detector, (4) a quantum memory, and (5) quantum bit devices. This group will also study
physical processes in light-plasmon interconversion for possible applications to plasmonic devices.
Energy Technology Group
Harnessing solar energy with nanostructures
This group will develop technologies based on nanostructures and nano processes to harness solar
energy as efficiently as possible. Specifically, (1) artificial photosynthesis through molecular
assemblies and the understanding and control of the processes involved, such as excitation, energy
transfer, electron transfer, and catalytic reactions, (2) light-assisted hydrogen storage, a new concept,
(3) high strength fuel cells, (4) inexpensive, high efficiency dye-sensitized solar cells on the basis of
light confinement effect with nanostructures, and (5) bioreactions in photosynthetic bacteria driven by
solar energy.
Medical Technology Group
Nanobiotechnology for medical applications
This group will develop nanobiotechnology for medical applications via approaches from nanobiology
and chemical biology, combined with newly developed nanomaterials. The four major objectives are:
(1) development of molecules for cancer diagnosis and therapy, (2) DNA binding molecules for
amplified oncogene detection and silencing, (3) development of a novel radiation dynamic therapy
against cancer cells in internal organs, and (4) peptide nucleic acid molecules for over-expressed genes
for disease diagnosis and therapy.
Nanoscience and Nanotechnology Groups: Supramolecules and Self-Assembly Group;
Nanomaterials and Nanotechnology Group; Quantum Theory and Computation Group
These groups will conduct basic scientific and technological studies on nanomaterials and
nanostructures as the basis for the above-mentioned application oriented developments. Bottom-up
approaches including self-assembly as well as top-down approaches including electron beam
lithography, combined with controlled reaction at the nanometer level, are exploited to prepare
nanomaterials and nanostructures. Photonic and quantum mechanical properties will be elucidated
with experimental approaches, together with theoretical and computational approaches. These studies
will lay the basis for the development of information, energy, and medical technologies being
developed by other groups as mentioned above. These groups will also provide a forum for the
interaction of researchers, facilitating the progress of this interdisciplinary project.
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Nihon University N.Research Project 2012
Table 1. The goals set at the beginning of the project.
Items
Status quo
Original technologies
Target
1. Information technology: super high speed/density recording and quantum information
writing speed
0.25 Gbits s–1
photoinduced
magnetization
25000 Gbits s–1
recording density
0.2 Tbits inch–2
nanomagnetic material
through self-assembly
2 Tbits inch–2
writing density
0.6 μm2/bit
near-field thermally
assisted recording
0.003 μm2/bit
single photon source
emission
efficiency10%
quantum dots
30%
low-noise single
photon detector
q. efficiency 1%
superconducting thin wire
50%, 10–8
photon number
resolving detector
resolution 0.2 ev
superconducting transition
edge sensor
0.2 ev, 1 MHz
quantum memory
1 mslow temp.
Bose condensates
10 ms
quantum bit device
q. efficiency ~1%
THz plasmonic quantum bit
>5%rt to 1.8 K
dark count~10–8
repetition 100
kHz
temp. <0.3 K
2. Energy: Harnessing solar energy with nanostructures
water photolysis
with supramolecules
not exist
self-assembly of sensitizer
and redox catalysts
to realize
light assisted
hydrogen storage
a new concept
light triggered desorption
that we have found
q. yield >0.1
high strength fuel
cell
strength 60 MPa
2–5 fold , 600 °C
temp 900 a new preparation process
from micro/nano particles
DSSC with
inexpensive dyes
energy efficiency
3%
light confinement effect of
nano structure
5%
bioreaction of photosynthetic organisms
rate 34 nmol/h/mg
genetically engineered
photosynthetic organisms
an order of magnitude
increase
>6 wt%
3. Medicine: Nanobio technologies for medical applications
probe compounds
for cancer
under
investigation
cancer specific compounds
identified
to realize
luminescent
compounds
safety, sensitivity
safe, long wavelength
luminescent compounds
detection of cancer marker
with compounds
ex vivo diagnosis
low diagnosis rate
highly sensitive and
specific diagnosis
diagnosis rate >80%
small error <10%
in vivo image
diagnosis
early detection of
cancer is difficult
improvement and low-cost
detection system
candidate compounds for
in vivo use
treatment of cancer
and other diseases
affecting normal
region
cancer-specific drugs and
new treatment
preclinical trial
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Nihon University N.Research Project 2012
Publications Records
Scientific Meetings
Books
Awards
Papers
Patent Applications
Invited Lectures
Presentation in
Research Grant
*The first numbers in the parentheses indicate the number of achievements by collaboration among
the members of this project. The second numbers in the parentheses indicate that the collaboration
involve the members of different colleges of the university.
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Nihon University N.Research Project 2012
Progress reports of groups
Information (Storage) Group
Information (Quantum Information) Group
Energy Technology Group
Medical Group
Supramolecules and Self-Assembly Group
Nanomaterials and Nanodevices Group
Quantum Theory and Computation Group
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Nihon University N.Research Project 2012
Information Storage Group
Katsuji Nakagawa*, Akiyoshi Itoh, Arata Tsukamoto
1. Overview of the research plan in 2012
1) To succeed in fabricating magnetic domains on magnetic recording film by the effect of surface
plasmon generated by femto-second laser, three issues will be performed: (1) a computational
analysis of electro-magnetic field as well as thermal diffusion in magnetic film, (2) a structure
design of surface plasmon antenna and antenna fabrication by electron beam lithography, and (3)
magnetic recording test applying femto-second laser with surface plasmon antenna.
2) In the matter of a super fast phenomenon, optical, thermal, and magnetic response from femtosecond laser light will be studied related to the issue 1).
3) The electro-magnetic field under the condition combining of dielectric optical waveguide and
surface plasmon polariton will be studied by computational calculation.
4) Nano-meter structured FeCuPt magnetic film for high density recording will be fabricated, and
stable magnetic domains will be studied by micro-magnetic computational calculation.
2. Advances and achievements in 2012
1) Thermally assisted magnetic recording with surface plasmon antenna has been succeeded by
applying femto-second laser. Three issues are key points of this success: (1) a computational
analysis of electro-magnetic field as well as thermal diffusion in magnetic film, (2) a structure
design of surface plasmon antenna and antenna fabrication by electron beam lithography, and (3)
magnetic recording test applying femto-second laser with surface plasmon antenna. The magnetic
mark of 166 nm x 120 nm was written by this method. The written mark size has not reached the
size of project goal: 77 nm x 77 nm. Our progress, however, is very big, and we still go forward to
our goal in the final year.
2) We found experimentally a novel magnetization reversal phenomenon in a ferri-magnetic GdFeCo
film driven by an ultrafast heating of the medium resulting from the absorption of a sub-picosecond
laser pulse without the presence of a magnetic field. Also relevantly to technological applications,
we have shown experimentally that switching can occur when the sample is at room temperature
before laser excitation.
3) We found that the combination of dielectric optical waveguide and surface plasmon polariton is
highly effective in optical energy transfer into small surface plasmon antenna. Besides, the
combination structure can also create circularly polarized light in a small region.
4) A rapid thermal annealing is effective to obtain high Ku (uniaxial magnetic anisotropy) as well as
small L10-FeCuPt grains. However, it revealed that each grain were mostly polycrystalline structure.
We found that an application of adequate additional annealing makes grains into L10 single
crystalline structures and grains kept almost similar size.
3. Collaborations and activities in 2012 as the group
A result about a nano-meter structured magnetic film with high uniaxial anisotropy was reported at an
international conference (ICM2012, July 8-12, Pusan). At another international conference
(ICAUMS2012, Oct. 1-5, 2012, Nara), six reports were also presented including femto-second laser
thermally assisted magnetic recording, dynamics in first magnetic reversal, recording materials, and
localized circularly polarized light. Some of these reports have been collaborated with Associate Prof.
Ohnuki. We have kept an inner meeting at least once a month.
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Nihon University N.Research Project 2012
Quantum Information Group
Shuichiro Inoue*, Takeshi Kuwamoto, Hideomi Hashiba
1. Overview of the research plan in 2012
1) Evaluation of the entanglement swapping system
2) Fabrication of a single-photon emitter using CdSe colloidal quantum dot array
3) Observation of electromagnetically induced transparency of orthogonally polarized photon pairs
and their storage in an atomic ensemble
4) Development of simple and reliable etching technique of Si on ICP
2. Advances and achievements in 2012
1) We performed fourfold coincidence measurements to investigate the indistinguishability between
photons from the two independent photon-pair sources. The indistinguishability was measured to
be 82 % by Hong-Ou-Mandel two-photon interference experiments. Then Bell-state measurements
were performed with one photon from each pair, which projected the two remaining photons,
formerly independent onto an entangled state. The obtained fidelity of the swapped entangled state
was 86 % (world record at telecommunication wavelengths), high enough to infer a violation of a
Bell-type inequality.
2) Fabrication technique of an array of colloidal quantum dots covered by silica has been developed.
The diameters of the quantum dot and the silica shell are 5 nm and 30 nm, respectively. We
attained a 55 nm wide, 1.5 μm long array of the quantum dots in sub one-dimensional shape using
a trench made of ZEP on Si substrate as a template.
3) We studied absorption of orthogonally polarized photon pairs into rubidium (Rb) vapor. The photon
pairs were filtered using several optical filters and two etalons so that they were resonant with Rb
atoms. At Rb-vapor temperature of 95 , the absorption ratio was reached approximately 97%.
However, at the vapor temperature of 70 , which was optimum one derived from classical-light
(laser-light) storage experiments, the absorption ratio was 90 %. In future, we improve the ratio to
100% by removing the non-resonant frequency components of photon pairs.
4) Fabrication technique of Si waveguides has been furbished and Si waveguides (320 nm wide and
more than 1 mm long) have been fabricated. The waveguides have small roughness of side-walls
(less than 10 nm) and the optical loss due to the roughness is to be measured.
3. Collaborations and activities in 2012 as the group
We proposed a multichannel single-photon emitting device which is composed of CdSe colloidal
quantum dot arrays and plasmonic waveguides. CdSe colloidal quantum dots were synthesized in Prof.
Ohtsuki’s lab and numerical calculations to design plasmonic waveguides were performed in Prof.
Ohnuki’s lab. We had three group meetings and discuss the direction of our final goal.
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Nihon University N.Research Project 2012
Energy Technology Group
Takuya Hashimoto,* Nobuyuki Nishimiya, Yasuo Asada, Sachiko Matsushita, Joe Otsuki
1. Overview of the research plan in 2012
The first object for solid oxide fuel cells (SOFC) is development of materials which construct SOFC,
which can be operated as low as 600 °C. The next one is construction of SOFC which can work at
600 °C.
On dye-sensitized solar cells, employment of photonic crystals or new dyes is examined and their
properties are clarified by various electrochemical and optical measurements. The targets of energy
conversion efficiency of the solar cells employing organic dyes and precious metal based ones are
more than 5% and around 10%, respectively.
Photonic to chemical energies transformation systems are to be developed through functionalizing
metal hydrides and specializing active bio-species on one hand and through confirming the concept on
the photo-assisted hydrogen absorption and adopting that to non-rare metallic combinations on the
other hand.
Preparation and characterization of supramolecular non-precious metal photocatalysts are also targets.
2. Advances and achievements in 2012
The optimization of preparation and sintering conditions of LaNi0.6Fe0.4O3-, which attract much
attention as Sr-free cathode material of SOFC, has been completed. For electrolyte material,
optimization of preparation method and kinds of trivalent ion of BaCe1-xMxO3- (M: trivalent ion) has
been carried out. As trivalent ion, it has been revealed that Y is the most suitable since ionic radii of
Y3+ is close to that of Ce4+. Also it has been clarified that the valence changes to tetravalent by
employing Nd as trivalent ion in order to adjust ionic radii for B-site, resulting in less oxide ion
vacancy and proton conductivity. Examination apparatus for SOFC has been successfully constructed
and fabrication of SOFC using above mentioned materials has started.
Using photonic crystals prepared by self-assembly methods, improvement of photon-to electron
conversion efficiency of dye-sensitized solar cells has been confirmed. Also, lithographic technique of
TiO2, which is base material for solar cells, is established. Dyes with varied structures were prepared
and tested as dyes for dye-sensitized solar cells. This year, however, has seen no improvement from
previously reported our efficiency record of 3.1%. As for precious metal dyes, model complexes were
prepared and characterized as a preceding step to the application to the dye-sensitized solar cells.
Bio-actively transferred hydrogen energy was successfully recovered by magnesium-based alloy
composites and the entity of hydrogen fermentation was partly specialized through DNA abstraction
from Yokohama National University’s active mixtures. Non-rare metallic composites comprising
boron, carbon and/or nitrogen provided with graphene-derived carbon nano-balls with high hydrogen
capacity as well as layered carbon nitrides with high performance photo-assisted hydrogen absorption
additives.
For supramolecular photocatalysts, the synthesis is ongoing. The major achievements of this year
was that discovery of double helices made of chlrophyll derived molecules, which will constitute a
basis for the design of artificial antenna systems and (ii) demonstration of lower temperature
processing for the fabrication of thin films of reduced graphene oxide, which will be used as the
substrate for organic photovoltaic
3. Collaborations and activities in 2012 as the group
Bio-activity transferred hydrogen is a collaborate work of Prof. Asada and Nishimiya. Patent of
preparation via Pechini process by Prof. Hashimoto is under way with the advice of Prof. Nishimiya.
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Nihon University N.Research Project 2012
Medical Group
Members
ARISH: Fukuda N, Severe Disease G: Saito K, Igarashi J, Fujiwara K, Soma M, Radiology: Abe O,
Ishibashi N, Urology Takahashi S, Pediatric Surgery: Koshinaga S, Bioresourse Science: Masuhiro Y,
Kano K, Pharmacy: Matsumoto Y, Aoyama T, Chiba Cancer: Nagase H, Watanabe T
Progress and Production by Whole Medical Group in 2012
1. Development of an E-box targeting Pyrrole-Imidazole polyamide to inhibit cell growth
(Fujiwara, Soma): PI polyamides targeting E-box consensus inhibited proliferation of the
osteosarcoma cell line treated with Myc-6 showing reduced growth rate by WST8 assay and colony
formation assay. In the wound-healing assay, Myc-6 inhibited cell migration activity dosedependently. Intravenous injection of Myc-6 once a week for a month caused growth inhibition
MG63 xenograft developed in Nude mouse without evidence of toxicity.
2. Development of antitumor PI polyamides for pediatric cancer (Koshinaga): PI polyamideshCCAAT1h-CCAAT3designed on the CAAT box in promoter reasion of LIT1 gene efficiently
suppressed expression of LIT1 gene and proliferation of Hepatoblastoma cell line (HuH6 clone5,
HepG2), and Wilm’s tumor cell line (G401).
3. Development of PI polyamide targeting human TGF-1 -Preclinical study- (Igarashi, Fukuda):
We confirmed that GB1101 is strongest to inhibit the expression of TGF-1 mRNA in human- and
marmoset-derived fibroblasts. We checked the combination of components of soluble materials and
solutions for PI polyamides and found that Macrogol Ointment was most effective substrate to
delivery the PI polyamide into skin. We examined e ffe c ts o f PI polyamides targeting human TGF1 on development of skin finrotic scar created in common marmosets and confirmed acual inhibition
of the skin scar.
4. Development of the Nihon University original methodology inducing iPS cells using the PI
polyamide targeting human TGF-1 (Saito, Fukuda, Masuhiro)We examined the iPS-producing
method establishment using proteolysis resistant cell-permeable proteins and the iniciation factor,
TGF-1 inhibitor, PI polyamide targeting human TGF-1, Apigenin, TGF- 1 antagonist and
Apigenin, and TGF- 1 a n d PI polyamide targeting human TGF-1.
5. Establishment of a breast cancer-inducing mouse model by the transplantation of DFAT
(Kano): We tried the creation of a breast cancer-inducing mouse model by the transplantation of
DFAT-GFP transfected oncogene, which is transformed to epithelial cells.
6. Histone acetylation of specific genomic region induced by PI polyamide-SAHA conjugate
(Nagase, Watanabe)We made considerable advances in coupling of existing drug SAHA that is
begin used as an HDAC inhibitor, to PI polyamides for targeting specific subsets of genes for
reactivation in cancers (e.g. Cdkn2a / p16). Watanabe developed a method of simple synthesis with
solid phase synthesis method using glutamic acid which is the usual amino acid. Six ring cyclic PI
polyamide was synthesized.
7. Pharmacokinetic/Pharmacodynamic Analysis of tumor-localizing photosensitizing compounds
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Nihon University N.Research Project 2012
(Matsumoto, Aoyama): To describe the relationships between effects following photodynamic
therapy, light dose, and plasma compound concentration, they developed a high-performance liquid
chromatography (HPLC) method for the determination of plasma concentration and investigate the
pharmacokinetics of novel compound CT101019a.
8. Development of plasma medicine for skin malignant melanoma (Saito, Fujiwara, Fukuda): We
started a project of the development of plasma medicine for skin malignant melanoma collaborating
with the plasma team in College of Science and Technology. This plasma medicine targets the
cancer stem cell with all trans retinoic acid to reduce the tolelance of radical oxygen species.
Activities of Medical Team in 2012
1) Meeting of N. Research team in every week.
2) Meetings four times in the collaborating institute Central Institute for Experimental Animals
Common marmoset team for the development of PI polyamide targeting TGF-1.
3) June: Meeting with the Drug Preparation Room in Nihon University School of Medicine Itabashi
Hospital and Clinical Pharmacokinetics team in College of Pharamacy about the development of PI
polyamide targeting TGF-1.
4) October: Meeting with the team in College of Pharamacy about the GLP grade phamakokinetics
study for PI polyamide targeting TGF-1
5) November: Meeting for the development of plasma medicine for skin malignant melanoma
collaborating with the plasma team in College of Science and Technology.
6) December: Presentation for the development of PI polyamide as practical medicine in College of
Pharmacy. 66
Nihon University N.Research Project 2012
Supramolecules and Self-Assembly Group
Hiroki Ikake*, Akiyoshi Itoh, Joe Otsuki, Arata Tsukamoto and Sachiko Matsushita
The goal of the supramolecules and self-assembly group is to develop advanced technologies on
nanomaterials and nanostructures and to supply these technologies to the application-oriented groups,
i.e., the information, energy, and medical groups, thus strongly promoting networking among these
groups on diverse fields. As follows, each groups theme in 2012.
· Itoh & Tsukamoto Group
We tried to prepare and utilize nano-structured substrates such as silica thin film having selfassembled nano-pores and self-assembled silica particle substrate. In 2012, we preformed additional
annealing to above isolated FeCuPt grains by using same annealing chamber of rapid thermal
annealing, for crystallizing those poly-crystal grains to form single crystalline grains. As a result, the
grain consists of c-axis oriented single crystalline structure from complementary results of X-ray
diffraction and electron beam diffraction. We found that an application of adequate additional
annealing makes grains into L10 single crystalline structures and grains kept almost similar size.
· Otsuki Group
Self-assembly of appropriately designed molecules will afford a bottom-up method for producing
nanostructures. This work aims at developing new molecular self-assembling systems, revealing selfassembled structures and dynamic behaviors at the molecular level, and searching for applications of
self-assembly to energy, medical, and information technologies through the collaboration with
researchers of the N. research project.
1. Self-Assembly of Molecules and Quantum Dots
2. New Dyes for Dye-Sensitized Solar Cells
· Matsushita Group
Two subjects related with self-assembly and self-organization were studied with perspective of the
developments of unexplored scientific fields and new technology.
1. Dye-sensitized photonic crystal electrodes
We examined the fluorescence inhibition effect of a self-assembled photonic crystal using Chlorine
e6 dye. Chlorine e6 is derived from chlorophyll and has a long excited electron lifetime.
2. Noble Planar and Symmetric Nanostructures in Prospective Plasmonic Devices
Noble planar and symmetric nanostructures, such as rod or spiny structures, were prepared by the
combination of colloidal self-assembly, thermal sintering and chemical etching, which enables the
tuning of both size of the particle and neck diameter. As a result, the rod structure showed the biggest
SERS effect among our structures in spite of the smallest amount of Au coating.
· Ikake Group
In our group, the aim of development of poly(L-lactic acid) (PLLA) films as biopolymer with the
high thermal- and mechanical- resistance. And then, the improved PLLA was submitted to new
material field. In particular, we have discussed as follows theme in 2012.
1. Preparation of High Crystallinity and High Orientation Poly(L-lactic acid) Films under
Electric Field
2. Morphological change of Poly(L-lactic acid) Films with Magnetic Irradiation
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Nihon University N.Research Project 2012
Nanomaterials and Nanodevices Group
Kaoru Suzuki*, Yoshiki Takano, Tomohiko Asai, Nobuyuki Iwata, Hideomi Hashiba,
Ken Judai and Shigeru Chaen
1. Overview of the research plan in 2012
This group aims at fabrication of nanomaterials and nanodevices for high functional applications such as 1)
Takano has a plan to prepare single phase samples of Sr1-xRxFeAsF(R=rare earth) and try to make thin films of
Sr1-xNdxFeAsF with collaboration with Prof. K. Suzuki. Quantum dot single-photon terahertz detector by Febased superconductor films, 2) Magnetic probe of Scanning probe microscope by Ni, etc. encapsulated carbon
nanotubes and semiconducting single-walled carbon nanotubes by controlling specific chirality for field effect
transistor, 3) Photocatalytic La,Sr,Ca:TiO2 films for hydrogen generation, storage and oxygen (hydrogen)
storage and release with metal oxides (metal hydrides) nanoparticles, 4) New photo-memory by highlyphotoluminescent material (NiO-ZrO2 solid solutions) and in-vitro single molecule imaging of these proteins
by membrane receptors.
Asai has a plan to 1) Development of rapid generation method of alloy thin-film by using a MCPG
Thin-film formation method with a MCPG has been studied for practical applications; TiZrFeMn film, titanium
oxide film and surface treatment of ceramic materials. 2) Medical application of LF plasma jet: Basic test device
of LF plasma jet for a cancer treatment has been developed and an experimental study has been initiated. 3)
Design study of new scenario of a muon-catalyzed nuclear fusion: Innovative scenario of a muon-catalyzed
nuclear fusion has been proposed and basic design study has been performed. The concept is utilize the “packman method” in a translated field-reversed configuration to realize hydrogen solid hydrogen pellet in a warm
plasma for an effective re-activation method for muon.
Hashiba plans in 2012 are as follows: Development of fabrication technics and Study of silicone wave guide
devices with its third-order nonlinearities, development of fabrication technics and Study of two dimensional
phonic crystals (PCs) of titanium oxide (TiO2) of low refractive index to meet the needs of the advanced solar
cells, and revealing higher order THz plasma excitations of quantum dots confined with shallow potential
barriers.
2. Advances and achievements in 2012
Prof. K. Suzuki approached 1)Metal encapsulated carbon nanotube for magnetic force microscope probes:The
diameter and length of the metal core is in the range of 10 – 80 nm and 100 – 800 nm with varying heating
period and temperature, respectively. The walls consist of cylindrical graphene sheets with 3 -50 layer.
2)Creation of carbon nano-tube/fiber and diamond-like carbon circuit:synthesized phosphorus doped n-type
carbon nano-tube/fiber by Joule heating on ethanol/Si surface, and diamond-like carbon films by ion beam
plating method. Type of p-n junction diode and wiring were created by focused Ga+ ion beam injection. 3)
Synthesize of photocatalytic SrxLa1-xTiO3 film for hydrogen generation on polymer films with visible area in
solar light excitation by laser induced forward transfer method: try to deposit of TiO2 on polymer films by laser
induced forward transfer method. 4)Synthesis of ZnO nano-films for light emitting device by infrared light
excited pulsed laser deposition method: High quality crystalline of p-type ZnO nano-films were improved by
pulsed YAG laser annealing below 532 nm of laser wavelength. 5)Bio-electronics:studied the sterilization of
periodontal
bacterium
by
atmosphere
pressure
low
frequency
jet
plasma;
fresh
plasma,
splintering/regeneration of enchytraeus japonensis by irradiation of free electron laser.
and
6)Green
technology:studied the evolution of controlled nano/micro bubble by laser/focused ion beam fabricated nozzle
on piezoelectric vibrator for defecation of water.
Prof. Y. Takano has prepared Sr1-xNdxFeAsF and obtained the high Tc superconductivity previously reported
in Sr1-xSmxFeAsF. Although he has tried to prepare single phase samples, they have not been obtained. On the
other hand, Takano has prepared F deficient SrFeAsF1-y and investigated their electrical properties. Although the
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Nihon University N.Research Project 2012
metallic conductivity is obtained, superconductivity is not observed above 3 K. However, he has found that the
decrease of Tc by y in optimum doped Sr1-xRxFeAsF1-y is independent of R ions. Takano has also investigated the
possibility of Sr1-xNdxFeAsF for the superconducting wire rod and obtained that the upper critical magnetic field
of this sample is higher than that of MgB 2 that has the highest critical current density.
Asso. Prof. T. Asai has developed 1) Basic and applied study on a magnetized plasmoid has been performed
in the project. In FY2012, the prospect of actually using a multi-pulsed magnetized plasmoid generation system
for a rapid generation of alloy thin film has been emerged and applied for a patent. Also, the invented technique
has started to be studied as an innovative surface treatment method for dental ceramics. 2) The feasibility of
medical applications of an atmosphere pressure LF jet plasma has been performed. Based on the results, a test
equipment of LF jet system has been developed. 3) For the basic study of self organization process of
magnetized plasmoid, an experimental device for a super Alfvenic velocity FRC translation has been developed.
The experiments on the newly developed device have been started in December 2012. The experimental facility
has also been applied for a feasibility test of a muon-catalyzed nuclear fusion.
Asso. Prof. N. Iwata has studied the selective growth of single-walled carbon nanotubes (SWNTs) with
specific chirality controlled by irradiating the FEL. The G/D ratio, which indicates quality of SWNT, was
significantly improved from about 30 to over 400 by developing a new substrate heater system.
[ABO3/REMO3](A=Ca,La, B=Fe,Mn,
RE=La,Bi,
M=Fe,Fe0.8Mn0.2) superlattices were deposited on surface
treated SrTiO3(100) substrates by pulsed laser deposition method; 3 types of CaFeO3(CFO)-series, 3 types of
CaMnO3(CMO)-series, 3 types of LaMnO3(LMO)-series.
oscillations were clearly observed.
In a 2- x-ray diffraction, satellite peaks and Laue
Those results indicate that the homogenous interface is created.
From the
results of reciprocal space mapping (RSM), all superlattices except for LMO/BiFe0.8Mn0.2O3(BFMO), cubu-oncube structure was observed with the film lattice fitted to the substrate lattice in-plain.
superlattices showed semiconducting behavior.
at higher temperature.
Sheet resistance of the
The EA of CMO and LMO single layer was 0.076 and 0.17eV
The EA of the superlatatice was smaller than the value of single layers, indicating that
the electron transfer, intermixing of cation at the interface, and modification of the band structure.
At the TC,
magnetic transition is expected. The author did the organizer at the biggest joint symposium in this field
(JSAP-MRS 2012 Spring Meeting).
The author was invited to the OMTAT international conference hold at
Kochi, India with the title of Oxides heterostructures for giant magnetoelectric effect.
The research has been
done with Prof. Hashimoto and IMS group of Univ. of Twente, Netherlands as a collaboration research.
In
addition, collaboration research with ETH Zrich, Swiss about the observation of antiferromagnetic domain of
Cr2O3 thin film using SHG technique was carried out.
The domain with Néel temp. of 307K was clearly
observed.
Asso. Prof. H. Hashiba has studied the 1)Research of silicone wave guide devices of this year has been focused
on development of simple fabrication method of the waveguides and we attained to develop concrete fabrication
method for a Si waveguide of 320 nm wide and more than 1 mm long. The waveguide has small roughness of
side-walls of less than 10 nm and accuracy of shape of the waveguide is restricted by our EBL. 2)Our TiO2 PCs
are fabricated with standard electron beam resist mask and deposition techniques of Ag-O2 mixture gas of 1:1.5
at 1 x 10-2 Torr. The patterned TiO2 film is then baked at 550 degrees and transform amorphous to mixture of
rutile and anatase. The observation of the layer under XRD measurement shows that some rutile turns into
anatase at that temperature. 3)Plasma excitations of QDs formed on a GaAs hetero-structure arises with a
formation of confinement potential barrier from the reservoir having resistances more than resistance quanta, and
we revealed that appropriate shape of the barriers lowers dark counts by suppression of flow of hot electrons
form the reservoir and reveals higher order excited states. The higher order excited states is expected to have the
same plasma frequency of that of the first and shows a heat bath effect of the QD. This will promise high
temperature operation of the THz detection.
Prof. S. Chaen and Prof. T. Tojo have succeeded in estimating ADP release rate from the displacement of
fluorescent nucleotides bound to myosin heads in the in vitro motility assay system by flash photolysis of caged
ATP. And they have developed a new wet cell system of Scanning Electron Microscopy to observe a living cell
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Nihon University N.Research Project 2012
in aqueous solution with at nanometer resolution.
Asso. Prof. K. Judai has studied the “self-assembled nano helix”. He found silver tolyl-acetylide molecules
self-assemble into nano helical morphology, however, the x-ray crystal structure analysis could not be performed
yet. He established also the method of the metallic cluster preparation for electrochemical analysis.
3. Collaborations and activities in 2012 as the group
Each crew has team meetings and offered the research sample, respectively. We obtained the several
collaborations results such as superconductor films, nanotube device, hydrogen generation/storage/release nanoparticles/films and single-moecule fluorescent imaging.
Hashiba has collaborative projects of “electric field dependence of polarity of molecular moters” with prof.
Otsuki, and “single photon emission from CdSe quantum dots coupled with metal waveguide” with Prof. Inoue.
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Nihon University N.Research Project 2012
Quantum Theory and Computation Group
Hiroshi Ishida, Shinichiro Ohnuki, Tokuei Sako,* Tsuneki Yamasaki
1. Overview of the research plan in 2012
IshidaElectronic structure and conductivity of singe-molecular chain linked between
metal electrodes are examined by the finite-temperature Green’s function method.Sako
Structure of conjugate Fermi holes in artificial atoms as well as natural atoms is examined and their
relation with electronic properties is rationalized.aOhnukiAiming at designing an
optimal plasmon antennas for the direct opto-magnetic recoding the localized field in the vicinity of
plasmonic antennas of various shape is examined.bOhnukiAn efficient numerical
method for solving coupled Maxwell and Schrödinger equation is established. YamasakiAn optimal structure of photonic crystal wave guide incorporating dielectric materials is
examined.
2. Advances and achievements in 2012
IshidaWe considered N-site Hubbard molecules linked between two metal electrodes
and examined their equilibrium electronic structure at temperature in the zero-bias limit by calculating
the finite-temperature Green's function. The integrated one-electron density of states (DOS) near the
chemical potential of metal electrodes for different gate voltage was examined. The result indicates the
formation the Kondo resonance at below the Kondo temperature (Phys. Rev. B, 2012). The present
scheme is shown to be capable of describing the electronic structure of adsorbed molecules in the wide
parameter range including the ballistic, Coulomb blockade, and Kondo regimes.
SakoThrough the continuing research of this N. project we have found last year the
existence of the so-called conjugate Fermi hole in the wave function of two electrons with antiparallel
spins. This year we have focused on artificial atoms and have examined in detail the structure of the
conjugate Fermi holes in the systems. As a consequence of the analysis, the origin of the first Hund
rule in artificial atoms has been rationalized, and the difference in the mechanism operating in
artificial atoms and in the corresponding He-like systems has been clarifiedJ. Phys. B, 2012
aOhnukiWe have designed plasmonic antennas to generate the localized circularly
polarized light inside the bit-patterned media for realizing ultra-high density magnetic recording.
Using the ADE-FDTD method, the generation time and the intensity of the localized circularly
polarized light are clarified in terms of the combination of cross antennas.
bOhnukiA nanoplate in laser fields is analyzed by the coupled Maxwell-Schrodinger
scheme which is based upon the FDTD method. We investigate the current densities and
electromagnetic fields near the nanoplate in terms of tunneling effects due to well structures.
Advantages of our proposed method are clarified in comparison with conventional classical solvers.
YamasakiWe have analyzed the guiding problem by dielectric waveguides with defects
composed of dielectric circular cylinders array and deformed rhombic dielectric structure in the
middle layer and investigated the influence of energy flow for the defect area by using the propagation
constants at the guided region. From the numerical results, it is shown that we can obtain the best
efficiency by rhombic dielectric structure compared with deformed rhombic dielectric structures in the
middle layer for both TE0 and TM0 modes.
3. Collaborations and activities in 2012 as the group
We have organized a meeting every month at Prof. Ohnuki’s laboratory with Prof. Nakagawa and
Dr. Ashizawa of Information Storage Group to study mainly theoretical methods for solving coupled
Maxwell and Schrödinger equations.
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Nihon University N.Research Project 2012
Progress reports of individual researchers
Yasuo ASADA
Energy Technology
Hydrogen Production by Photosynthetic Microorganisms with the use of Hydrogen-Absorving Metals and
Biocatalitic Reduction of Isooxsasoles
Tomohiko ASAI
Nanomaterials and Nanodevices
Control of Self-Organized Magnetized Plasmoids and Their Applications to Nano-Materials and Medical
Technologies
Shigeru CHAEN and Tadashi TOJO
Imaging of Bio-molecule and Cell
Nanomaterials and Nanodevices
Kyoko FUJIWARA and Masayoshi SOMA
Medical
Development of an E-box targeting Pyrrole-Imidazole polyamide to inhibit cell growth
Noboru FUKUDA, Kosuke SAITO, Jun IGARASHI and Tomohiko ASAI
Medical
Drug Discovery of Pyrrole-Imidazole (PI) Polyamide by the Chemical Biology and Development of Plasma
Medicine for Skin Malignant Melanoma
Hideomi HASHIBA
Quantum Information; Nanomaterials and Nanodevices
Single Photon Optoelectronics Devices
Takuya HASHIMOTO
Energy Technology
Development of Materials for Intermediate-Temperature Solid Oxide Fuel Cells
Hiroki IKAKE
Supramolecules and Self-Assembly
Development of Poly(lactic acid)s Films as Biopolymer, and Applications to New Material Field
Shuichiro INOUE
Quantum Information
High Fidelity Entanglement Swapping at Telecommunication Wavelengths
Hiroshi ISHIDA
Quantum Theory and Computation
Electronic Structure Calculation of Crystal Interfaces, Adsorbed Molecules, and Nanostructures
Akiyoshi ITOH, Arata TSUKAMOTO
Information Storage; Supramolecules and Self-Assembly
Ultra High Density Information Recording Materials on Self Assembled Nano-structured Substrates
Nobuyuki IWATA
Nanomaterials and Nanodevices
Pursuing the Limits of Nanomaterial-based Photonic and Quantum Technologies
Ken JUDAI
Nanomaterials and Nanodevices
Preparation of Metallic Clusters in Solution and Applications to Catalysis
Koichiro KANO
Medical
Actin Cytoskelton Dynamics Control Adipocyte Differentiation Via Regulation of MKL1
Tsugumichi KOSHINAGA
Medical
Anti-tumor Effect of Inhibition LIT1 Gene Transcription by using as New Therapeutic Agent
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Nihon University N.Research Project 2012
Takeshi KUWAMOTO
Quantum Information
Experimental Studies for Quantum Memory Using Neutral Atoms
Yoshikazu MASUHIRO
Medical
Construction of the Escherichia Coli Expression System of the Cell Membrane Permeable iPSCs Induced
Factors That Strengthened Proteolysis Resistance
Yoshiaki MATSUMOTO and Takahiko AOYAMA
Medical
Pharmacokinetic/Pharmacodynamic Analysis of Tumor-localizing Photosensitizing Compounds
Sachiko MATSUSHITA
Supramolecules and Self-Assembly ; Energy Technology
Self-assembly and Self-organization from the viewpoint of Device-fabrication Methods
Hiroki NAGASE and Takayoshi WATANABE Medical
Applied Chemical Biology: Strategy to Cure Cancer Patients
Katsuji NAKAGAWA
Information Storage
Research for High Density and High Speed Magnetic Recording- Thermally Assisted Magnetic Recording
Applying Near Field Optical Light Nobuyuki NISHIMIYA
Energy Technology
Development of Photonic to Chemical Energies Transformation Systems
Shinichiro OHNUKI
Quantum Theory and Computation
Nano-Electromagnetic Simulation and Its Applications to Plasmonic Devices
Joe OTSUKI
Supramolecules and Self-Assembly; Energy Technology
Self-Assembled Supramolecules and Their Applications to Energy, Medical, and Information Technologies
Tokuei SAKO
Quantum Theory and Computation
Comparison of the Structure of Conjugate Fermi Holes in He-like Systems and Artificial Atoms
Kaoru SUZUKI
Nanomaterials and Nanodevices
Synthesis of Nano-rod Devices with Wide Band Gap Semiconductor Effect
Satosu TAKAHASHI and Daisuke OBINATA Medical
The Development of Newly Molecular Targeting Drug for Prostate Cancer by using PI polyamide
Yoshiki TAKANO
Nanomaterials and Nanodevices
Mechanism of Superconductivity in Layered Fe-based Superconductors and Search of New Superconducting
Compounds
Arata TSUKAMOTO, Akiyoshi ITOH
Information Storage; Supramolecules and Self-Assembly
Ultra Fast Information Recording and Ultra Fast Photo Magnetic Switching
Tsuneki YAMASAKI
Quantum Theory and Computation
Distribution of Energy Flow by Dielectric Waveguide withRhombic Dielectric Structures along a Middle Layer
–Case of Compared with Deformed Rhombic Dielectric Structure–
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Nihon University N.Research Project 2012
Hydrogen Production by Photosynthetic Microorganisms with the use of Hydrogen-Absorving
Metals and Biocatalitic Reduction of Isooxsasoles
Yasuo ASADA
Energy Technology Group
Hydrogen production by cyanobacteria combined use of hydrogen-absorbing metals and biocatalitic
reduction of isooxasoles and acetophenon using photosynthetic bacteria, are studied.
1. Hydrogen production by photosynthetic microorganisms with the use of hydrogen-absorbing
metals (Co-works with Prof.Nishimiya, CST, Nihon-Univ.)
The new methods to collect and stimulate hydrogen produced by cyanobacteria with the use of
hydrogen-absorbing metals.
The hydrogen gas produced by cyanobacteria, Spirulina platensis and Anabaena cylindrical was
collected with hydrogen-absorbing metals. By reducing hydrogen partial pressure, the hydrogen
production by cyanobacteria, was stimulated. Spirulina platensis produces hydrogen gas by anaerobic
digestion of intracellular glycogen.
However, the stored hydrogen gas is inhibitory for the hydrogen production. By lowering hydrogen
partial pressure with the use of hydrogen-absorbing metals, hydrogen production was stimulated.
In this fiscal year, the positive effect of hydrogen-absorbing metals on production by Enterobacter
aerogenes (a kind of facultative anaerobic bacteria) was confirmed.
2. Biocatalitic reduction of isooxasoles and acetophenon by photosynthetic bacteria
Biocatalitic and assymetrical reduction of isooxasoles and acetophenons by photosynthetic bacteria
are studied.
Intact cells of some cyanobacteria are known to convert isooxasoles to its alcohol form. The
responsible enzyme is assumed to be alcohol dehydrogenase(s), but there has been detailed
information. The aim of study is to clarify the responsible enzyme and strengthen the activity by
genetic engineering.
We have already acquired transconjugant photosynthetic bacterium, Rhodobacter sphaeroides RV
with three alcohol dehydrogenase (ADH) enzyme genes from the cyanobacterium, Synechococcus
PCC7942 and one ADH gene from alcohol-assimilating photosynthetic bacterium,
This fiscal year, we tried to analyze ADH activity by activity staining of native electrophoresis. The
cell-free extracts from Rhodopeudomonas palustris No.7 in the gels was able to oxidize S-form 1phenyl alcohol to acetophenon but not R-form.
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Nihon University N.Research Project 2012
Control of Self-Organized Magnetized Plasmoids and Their Applications
to Nano-Materials and Medical Technologies
Tomohiko Asai
Nanomaterials and Nanodevices Group
Self-organized magnetized plasmoid has attractive advantages for the variety of applications because
of its wide range of plasma parameters and its ease of control. In this work, applications of the
magnetized plasmoid for a rapid thin-film deposition and EUV light source have been proposed and
demonstrated. Also, several innovative applications of the plasma formation technique, e.g. medical
treatment and muon catalyzed nuclear fusion have been proposed and initiated in this project.
1. Development of high-speed film deposition technique by magnetized coaxial plasma gun
Magnetized Coaxial Plasma Gun (MCPG) has been applied for new alloy film deposition technique.
This method realize the generation of metallic thin film with the materials which have high-meltingpoint (e.g., Ti, Zr …). Generation methods for these materials had been limited to the ion beam
assisted vacuum deposition. The optimization of gun operation and the initial experiment with
composite material electrode have been successfully performed. The developed technique had been
applied for a patent via NUBIC. ”Fast alloy film deposition method”by Tomohiko Asai, Kaoru
Suzuki, Nobuyuki Nishimiya, Mikio Takatsu, 2012.9.6 (JP2012-195690
(Collaboration with Prof. K. Suzuki and Prof. N. Nishimiya)
2. Application of LF Plasma jet for Medical Treatments
The atmospheric-pressure LF (Low Frequency) plasma jet have been investigated to apply for
surface modification technique of e.g. CNT composite materials. The application study of the LF jet
for medical treatment has recently been initiated. The high energy electron and ions supplied by the LF
jet have a potential to be a tool to control chemical balance of cells in addition to the direct effect of
hot particles.
In this project, the study is focusing on the
application of LF jet on the cancer treatment. The
experimental device has been developed (Figure
1) and the initial experiments will be started
within this fiscal year.
(Collaboration with Prof. N. Fukuda, Dr. K.
Fujiwara, Dr. H. Koguchi (AIST) et al.)
3. High-efficiency method of muon catalyzed
fusion
The muon catalyzed fusion (μCF) is one of the
nuclear fusion reaction processes caused in a μatom. To improve the efficiency of μCF,
innovative concept of fusion reactor design has
been proposed and preliminary experiments on a
super-Alfvénic translated FRC (Field-Reversed
Configuration) plasma (Figure 2) have been
initiated. (Collaboration with Dr. E. Nakamura,
KEK)
Figure 1. LF jet for a medical applications.
Figure 2. FAT device.
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Nihon University N.Research Project 2012
Imaging of Bio-molecule and Cell
Shigeru CHAEN and Tadashi TOJO
Nanomaterials and Nanodevice Group
1. Studies on the biomolecular motor using the ordinary fluorescent imaging technique.
In vitro motility assays using bipolar
fluorescent actin filament
myosin thick filaments demonstrated
backward (slow)
forward (fast)
that actin filaments slides slower in the
direction leading away from the central
zone than towards it. Recently, we have
myosin filament
suggested that the backward movement
causes the myosin heads to be constrained and increase in the energy required for the ADP release step
by the findings that the thermal activation energy. In this study, in order to examine whether ADP
release rate is slower in the backward than the forward
movement, we constructed an assay system to estimate the ADP
release rate from the displacement of fluorescent nucleotides
bound to myosin heads by flash photolysis of caged ATP. Using
the new assay system, we obtained that ADP release rate is
slower in the backward than the forward movement.
(BIOPHYSICS in press. 2013)
2. Development of a new wet cell using a carbon thin diaphragm to observe a living cell in
aqueous solution with Scanning Electron Microscopy at nanometer resolution
In electron microscopy, transparency of specimens against a beam of electrons in TEM or intensity
of secondary electrons and so on induced by an incident electron beam in SEM is translated into
contrast. Any material surrounding a specimen, which prevents electron beam passing or detection of
secondary electrons, obstructs to create an image. Hence, electron microscopy intrinsically requires
high voltage electron beam irradiation of specimens and high vacuum under 10-4 Pa in the cell for
specimens. Water in samples must be replaced with some resins or completely dried up. These
conditions make it difficult to observe wet or living samples like enzymes retaining catalytic activities
or living cells in aqueous solution. To image wet and living samples using electron microscopy at
nanometer resolution, we are developing a new wet cell for SEM whereby living cells and enzymes
can be maintained in aqueous solution. A carbon thin layer with thickness of 20 nm was made by
vacuum evaporation. We applied it as a diaphragm withstanding a pressure gap for separating a
specimen in solution at atmospheric pressure from high vacuum environment. Cells and enzymes were
placed on its surface of the atmospheric side. They were imaged using SEM. The EM photographs
show detailed structures of the cell membrane and the enzymes.
Ventral membranes of CHO cells
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Nihon University N.Research Project 2012
Development of an E-box Targeting Pyrrole-Imidazole Polyamide to Inhibit Cell Growth
Masayoshi SOMA, Kyoko FUJIWARA
Medical Group
The amplification or over expression of c-MYC has been observed in many tumors. c-MYC
is a basics-helix-loop-helix leucine zipper transcription factor that binds E-box (5’-CACGTG-3’)
sequence of DNA with its partner MAX protein. It activates the transcription of more than 4000 genes
whose products are involved in crucial aspects of cancer biology such as cell proliferation, cell growth,
apoptosis and differentiation. There have been many approaches to down regulate MYC or its
downstream genes, however, none of them has been succeeded to be developed as an anti-cancer
drugs, because of the lack of drug-delivery system, or too complex treatment procedure.
Pyrrole–imidazole (PI) polyamides can bind to double strand DNA in a sequence specific
manner and suppress the expression of target gene by inhibiting DNA binding proteins including
transcription factors. PI polyamides are small synthetic molecules composed of the aromatic amino
acids N-methylpyrrole (Py) and N-methylimidazole (Im). A pair of PI polyamide recognizes specific
DNA base pairs, i.e. Im/Py pair bind to G-C, Py/Im to C-G, and Py/Py to both A-T and T-A. A
concatenation of those pairs made it possible to bind to a variety of specific DNA sequences.
We designed several PI polyamides which recognize E-box consensus, and found that one of
those PI polyamide Myc-6 inhibits proliferation of the many cells including osteosarcoma cell line
MG63. The cells treated with 1mM or higher concentration of Myc-6 showed reduced growth rate
when they were examined by WST8 assay and colony formation assay. It was also revealed by
wound-healing assay that Myc-6 inhibited cell migration activity dose-dependently. Intravenous
injection of Myc-6 at 6 mg/kg body weight once a week for a month caused growth inhibition MG63
xenograft developed in Nude mouse without evidence of toxicity. It was also observed that Myc-6
treatment increased the amount of phosphatidyl serine, which is the marker of early apoptosis, on cell
membrane, however, no clear evidence of late apoptosis or necrosis was found.
By global gene expression analysis using Affymetrix
GeneChip U133 Plus, 18 genes were found to be significantly
down-regulated in MG63 cells treated with 10mM Myc-6.
Even though we failed to find the direct target genes of Myc-6
polyamide, we found that extracellular matrix related genes, such
as Collagen 3A1, 14A1, Matrix metalloproteinase 1, and the
genes involved in RNA maturation, such as MALAT1 and NEAT1
were down regulated by Myc-6 treatment. Since those genes
could be involved in regulating growth and/or migration of
tumor cells, and could be a new therapeutic target, we are doing
further functional analysis of them.
Fig.1
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Growth inhibition of MG63 cells by Myc-6 treatment.
Nihon University N.Research Project 2012
Drug Discovery of Pyrrole-Imidazole (PI) Polyamide by the Chemical Biology and
Development of Plasma Medicine for Skin Malignant Melanoma
Noboru FUKUDA, Jun IGARASHI, Kousuke SAITO and Tomohiko ASAI
Medical Group
To develop DNA-recognized PI polyamide targeting human TGF-1 as practical medicines, we
tried to determine a lead compound, and provide the preclinical studies using common marmosets. We
also develop the Nihon University original methodology to induce iPS cells using the PI polyamide
targeting human TGF-1. Moreover, we started a project of the development of plasma medicine for
skin malignant melanoma collaborating with the plasma team in College of Science and Technology.
I.
Determination of a lead compound targeting human TGF-1 Among seven PI polyamides designed to bind on the promoter region of human TGF-1 gene,
we selected GB1101, GB1105, and GB1106, and examined their effects on expression of TGF-1
mRNA in humen cultured vascular smooth muscles. GB1105 and GB1106 strongly inhibited
expression of TGF-1 mRNA in a dose-dependent manner. We confirmed that GB1101 is
strongest to inhibit the expression of TGF-1 mRNA in human- and marmoset-derived
fibroblasts.
II.
Establishment of ointment containing PI polyamide targeting human TGF-1
We start to establish ointment containing PI polyamide targeting human TGF-1 to develop PI
polyamide as a practical medicine for the skin hypertrophic scar collonborating with solution
manufacturing room in Nihon University Itabashi Hospital. We checked the combination of
components of soluble materials and solutions for PI polyamides and found that Macrogol
Ointment was most effective substrate to delivery the PI polyamide into skin.
III. Preclinical study for PI polyamides using common marmosets
The preclical study using the primates is essential to develop PI polyamides. We chose common
marmosets that are compact and have a reproductive power for the preclinical study. We
examined e ffe c ts o f PI polyamides targeting human TGF-1 on development of skin finrotic
scar created in common marmosets and confirmed acual inhibition of the skin scar.
IV. Development of the Nihon University original methodology to induce iPS cells using the PI
polyamide targeting human TGF-1
1)
2)
V.
We evaluated the effect of PI polyamides to induce EMT on human mammary epithelial cell lines by
assay for examining cell proliferation and migration activity. As a result, Treated group showed lower
expression activity level of TGF-1 and Snail genes, which are involved in EMT. These results suggest
that those PI polyamides may be useful for inhibit EMT in human mammary epithelial cells.
Currently, We have tried to induce human iPS to administer to HDF cells proteins, which cell extracts of
293T stable expression cell strains of Flag-Sox2 or Oct4 or Klf4-11R, and Flag-Sox2-Stabilon-11R fusion
proteins and 6His tag conjugated MTM-cMYC fusion protein constructed by E. coli expression system,
and TGF- 1 inhibitors, human TGF- 1 specific PI polyamides, Apigenin which a flavonoid
that increases the expression of E-cadherin, TGF- 1 inhibitors and human TGF- 1 specific PI
polyamide, human TGF- 1 specific PI polyamide and Apigenin, when change the human iPS induced
medium after reseed the cells on feeder cells.
Development of plasma medicine for skin malignant melanoma
We started a project of the development of plasma medicine for skin malignant melanoma
collaborating with the plasma team in College of Science and Technology. This plasma medicine
targets the cancer stem cell with all trans retinoic acid to reduce the tolelance of radical oxygen
species.
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Nihon University N.Research Project 2012
Single Photon Optoelectronics Devices
Hideomi HASHIBA
Nanomaterials and Nanodevices Group; Quantum Information Group
Our research aims development of single photon optoelectronic devices. Our research has focused
on silicone waveguides for quantum information transport, two dimensional TiO2 photonic crystals of
low refractive index for solar cells, and single photon detectors for THz range this year.
1. Development of fabrication technology of silicone waveguides with ICP etching
Semiconductor wave guides and photonic crystals are increasingly important in optoelectronic
devices for quantum information technology. We study silicone wave guide devices with its thirdorder nonlinearities. Research of silicone wave guide devices of this year has been focused on
development of simple fabrication method of the waveguides and we attained to develop concrete
fabrication method for a Si waveguide of 320 nm wide and more than 1 mm long. The waveguide has
small roughness of side-walls of less than 10 nm and accuracy of shape of the waveguide is restricted
by our EBL.
2. Two dimensional TiO2 photonic crystal as photo sensitized solar cell
Two dimensional phonic crystals (PCs) of titanium oxide (TiO2) of low refractive index to meet the
needs of the advanced solar cells. Our PCs are fabricated with standard electron beam resist mask and
deposition techniques of Ag-O2 mixture gas of 1:1.5 at 1 x 10-2 Torr. The patterned TiO2 film is then
baked at 550 degrees and transform amorphous to mixture of rutile and anatase. The observation of the
layer under XRD measurement shows that some rutile turns into anatase at that temperature.
3. THz plasma excitations of quantum dots confined
with shallow potential barriers
We studied the “Single-electron transistors in THz
range“. THz range single photon detectors are assembled
from a GaAs/AlGaAs quantum dot coupled with a metallic
single electron transistor which senses appearance of
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500
T e le g r a p h c o u n ts
charge state of the QD. Plasma excitations of the QD
arises with a formation of confinement potential barrier
from the reservoir having resistances more than resistance
quanta, and we revealed that appropriate shape of the
barriers lowers dark counts by suppression of flow of hot
electrons form the reservoir and reveals higher order
excited states. The higher order excited states is expected
to have the same plasma frequency of that of the first and
shows a heat bath effect of the QD. This will promise high
temperature operation of the THz detection.
400
300
200
100
0
- 0 .3
- 0 .2
- 0 .1
0 .0
0 .1
0 .2
C o n d u c ta n c e , a r b .
0 .3
0 .4
Nihon University N.Research Project 2012
Development of Materials for Intermediate-Temperature Solid Oxide Fuel Cells
Takuya HASHIMOTO
Energy Technology
Solid oxide fuel cells (SOFC) attract much interest due to high efficiency and low emission of
pollution gas. At present, operation temperature of SOFC is about 800~1000 °C, which should be
reduced to 600~800 °C for practical application. In order to reduce operating temperature, new
materials for cathode, electrolyte and anode which work at such a low temperature are necessary. In
this year, potential of materials listed below has been examined. Fabrication of SOFC by combination
of the examined materials and its evaluation are now in progress.
1. Optimization of preparation method and sintering temperature of LaNi0.6Fe0.4O3- as new
cathode material and its stability at low oxygen partial pressures
LaNi0.6Fe0.4O3- attracts interest as new cathode material due to low chemical reactivity with
electrolyte material originating from free of Sr. So far, it has been clarified that single phase
specimens with high homogeneity and large Ni content can be prepared with one of the solution
process, Pechini method instead of frequently employed solid state reaction method. In this year, it has
been concluded that sintering of LaNi0.6Fe0.4O3- powder prepared by Pechini method at 1050 °C
produces sintering body with sintering density of 70 %, high specific surface area and homogeneous
pore size distribution, which are ideal as cathode material. (Mater. Res. Bull. 2013) Comparison of
LaNi0.6Fe0.4O3- sintering bodies prepared by other solution processes has been carried out and it has
been revealed that Pechini process employed in this study is superior from the viewpoint of
controllability of sintering density and homogeneity of pore size distribution. (J. Amer. Ceram. Soc.
2012) For practical application, electrical property under low oxygen partial pressure is also an
important factor since cathode is exposed to low oxygen chemical potential under SOFC operation. It
has been clarified that LaNi0.6Fe0.4O3- shows electrical conductivity more than 130 S·cm-1 below
700 °C despite of oxygen partial pressure as low as 10-4 atm
2. Optimization of preparation method and rare earth cation in BaCe1-xMxO3- (M: rare earth
metal)
BaCe1-xMxO3- (M: rare earth metal) is one of the candidate for alternative electrolyte materials
because of high proton conductivity at 400~600 °C. At last year, single phase preparation by Pechini
method has been succeeded; however, optimization of rare earth ion has not been performed. In this
year, X-ray diffraction measurements at high temperatures under controlled oxygen partial pressures
have been performed and rare earth ion in BaCe1-xMxO3- has been optimized from the viewpoint of
structural analysis. For the specimens with M=Y, Sm, Eu, Dy and Yb, only thermal expansion was
observed and reduction expansion due to generation of oxide ion vacancy was not detected. For BaCe1xNdxO3-, not only thermal expansion but also reduction expansion originating from variation of was
observed. This indicated that valence of Nd in BaCe1-xNdxO3- was tetravalent state at room
temperature and varied to trivalent at high temperatures. The valence of Nd thus concluded showed
agreement with lower molar volume, and proton conductivity than those of other BaCe1-xMxO3- .
3. Preparation of single phase of Sr2-xLaxFeMO6 (M: W, Mo) as new anode materials
For the purpose of preparation of SOFC composed of all perovskite materials, double perovskite
oxide which is stable under reductive atmosphere has been examined as anode materials. For the first
step, preparation of Sr2-xLaxFeMO6 (M: W, Mo) has been examined and single phase specimens have
been prepared. The property as anode materials is now in evaluation.
80
Nihon University N.Research Project 2012
Development of Poly(lactic acid)s Films as Biopolymer, and Applications to New Material Field
Hiroki IKAKE
Supramolecular and Self-Assembly Group
In our group, the aim of development of poly(lactic acid) (PLA) films as biopolymer with the high
thermal- and mechanical- resistance. And then, the improved PLA was submitted to new material field.
1. Development of Poly(L-lactic acid) Films with Exhibiting the Piezoelectricity
It is well known that poly(L-lactic acid) (PLLA) fibers exhibit the piezoelectricity, in which their
piezoelectric constant increases with increasing degree of
crystallinity and uniformity of the orientation of the crystallites.
Recently, bending motion due to their piezoelectricity has been
reported (Fig.1). The zigzag motion is closely related to the
morphology of PLLA fibers. For this purpose, the irradiated
magnetic field, and other process, under the electric field, have
produced the high crystalline oriented PLLA films. In the present
study, we have successfully synthesized PLLA by using Ringopening polymerization, and the crystalline of PLLA became the
growth by the isothermal crystallization process.
0kV/m
1.0kV/m
2.0kV/m
3.0kV/m
Intensity (a.u)
2. Preparation of High Crystallinity and High Orientation
Poly(L-lactic acid) Films under Electric Field
Semi-crystallized PLLA has a comparatively low-degree of
crystallization (Xc). In order to orient its crystalline domains in a
regular way and to raise Xc, electric field was applied to PLLA film
while annealing it according to a program. In Fig.2, the
dependency of the azimuthal angle for PLLA films at 16.7° caused
of the (110)/(200) planes by wide-angle X-ray diffraction. As the
results, it was shown that the crystalline domains have oriented in
parallel to the direction of the various applied electric field, and
the degree of orientation has become increased with increasing
applied electric field.
0
60
120
180
240
300
360
Azimuthal angle / degree (°)
Fig.2 WAXD(110)/(200) intensity along
the azimuthal angle for PLLA films.
2
I(q)q (-)
3. Morphological change of Poly(L-lactic acid) Films with Magnetic Irradiation
170°C
In this study, we have discussed that the influence of
175°C
180°C
morphological change of PLLA films on magnetic irradiation.
185°C
only annealing
The annealing process for PLLA films was the same as in the
electric field’s program. In the results of small angle X-ray
(SAXS) profiles for annealed PLLA films, SAXS peak shifted to
lower scattering wave vector: q value with increasing the
annealing time at isothermal crystallization process. In Fig.3, the
dependency of the annealing temperature for PLLA films at
isothermal crystallization process in 0T. As the results, it was
0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45 0.5
shown that the PLLA lamellar thickness have increased with
-1
q(nm )
increasing the annealing temperature, but the SAXS peak of
Fig.3 SAXS Lorentz-corrected plots of
annealed PLLA film at 185°C disappeared due to be smaller PLLA films as a function of the annealing
lamellar thickness with increasing the annealing temperature.
temperature at isothermal crystallization.
81
Nihon University N.Research Project 2012
High Fidelity Entanglement Swapping at Telecommunication Wavelengths
Shuichiro INOUE
Quantum Information Group
Quantum key distribution (QKD) technology has made significant progress in the last decade and
the key distribution distance of 200 km has been achieved using a point-to-point QKD system.
However, further extension of the key distribution distance using such a system would be difficult,
because the error probability scales exponentially with a fiber distance. The promising way to extend
the key distribution distance further is to employ quantum repeaters. The preliminary step toward
constructing the quantum repeater system is to implement a quantum relay that is a QKD using
entanglement distributed via entanglement swapping. In this project, we have demonstrated the high
fidelity entanglement swapping at telecommunication wavelengths.
1. Development of polarization entangled photon-pair sources
In the entanglement swapping, it is important to make photons from two independent photon-pair
sources indistinguishable. The photons must be identical in their spectral, spatial, polarization, and
temporal modes in a Bell-state measurement. The temporal overlap was achieved by the use of
synchronized femtosecond pump pulses (approximately 100 fs duration at 79.6 MHz repetition rate)
and narrow bandpass filters (FWHM: 4 nm). The pulses have a center wavelength of 775 nm. Two
spatially separated 6-mm long type-II periodically poled lithium niobate (PPLN) bulk crystals were
pumped by the synchronized pulses and generated cross-polarized photon pairs at 1550 nm via a
spontaneous parametric down conversion process. The generated photon pairs were detected by 1.28GHz sinusoidally gated InGaAs/InP avalanche photodiodes. The visibility of the two-photon
interference using each photon-pair source was 87 %. The imperfect visibility was due to the multi
photon-pair generation caused by the high pumping.
2. Polarization entanglement swapping
We performed fourfold coincidence measurements to investigate the indistinguishability between
photons from the two independent photon-pair sources. The indistinguishability was measured to be
82 % by Hong-Ou-Mandel two-photon interference experiments (Fig.1) Then a partial Bell-state
measurement was performed with one photon from each pair, which projected the two remaining
photons, formerly independent onto an entangled state. The obtained fidelity of the swapped entangled
state was 86 % (Fig. 2), high enough to infer a violation of a Bell-type inequality. Our configuration
would be a prototype solution for use in future quantum relay and quantum repeaters over long
distance optical fiber networks.
45-4522.5-22.5
Fig.1 Hong-Ou-Mandel dip by photons from
Fig.2 Two-photon interference fringes after the
independent photon-pair sources
entanglement swapping
82
Nihon University N.Research Project 2012
Electronic structure calculation of crystal interfaces, adsorbed molecules, and nanostructures
Hiroshi ISHIDA
Theory and Simulation
Recent progress in microfabrication technology has enabled the synthesis of superlattices with
atomically controlled layer thicknesses and single molecule transistors. We aim at clarifying the
electronic structure of these systems, including the effects of strong Coulomb correlations, by combing
first-principles density-functional calculations and many-body techniques like dynamical mean-field
theory.
1. Coulomb blockade and Kondo effect in the Hubbard molecules
We considered N -site Hubbard molecules linked
between two metal electrodes (Fig.1) and examined their
equilibrium electronic structure at temperature T in the
zero-bias limit by calculating the finite-temperature
Green's function. Here, U denotes the onsite Coulomb
repulsion energy, while t L t M , and t = 1 chosen as
unit of energy) are the hopping integral between the
molecule and metal electrodes, that between neighboring
sites in metal electrodes, and that between neighboring
sites in the molecule, respectively. In the calculation, two semi-infinite electrodes are approximated by
finite-size clusters, and the Green's function of the resultant finite system is calculated by applying
exact diagonalization.
As an example, we consider a 3-site chain molecule.
Fig. 2 shows its integrated one-electron density of
states (DOS) near the chemical potential of metal
electrodes, μ for four temperature values, when μ (alternatively, the gate voltage of the molecule) is
varied. While DOS of the non-interacting molecule
exhibits three peaks originating from three molecular
orbitals, each of them splits into a double-peak
structure as a result of the Coulomb blockade.
Moreover, the quasi-Coulomb gap of the second
molecular orbital is seen to disappear at lower
temperatures, indicating the formation the Kondo resonance at μ below the Kondo temperature (Phys.
Rev. B, 2012) These results demonstrate that the present scheme is capable of describing the
electronic structure of adsorbed molecules in the wide parameter range including the ballistic,
Coulomb blockade, and Kondo regimes.
2. First-principles embedded Green's function code including the spin-orbit coupling
We are currently working on implementing the spin-orbit coupling term in our first-principles
computer code for calculatng the electronic structure of semi-infinite surfaces and interfaces based on
density-functional theory and the embedding tehnique of Inglesfield. Our method will be able to
calculate, for example, the electronic structre of topological insulators, especially, the spin-polarized
metallic surface states of these materials, more accurately than standard slab calculations.
83
Nihon University N.Research Project 2012
Ultra High Density Information Recording Materials
on Self Assembled Nano-structured Substrates
Akiyoshi ITOH, Arata TSUKAMOTO
Information Storage Group; Supramolecules and Self-Assembly Group
In recent years, much attention has been focused on nano-structured magnetic media for achieving
ultra high density recording up to several Tbit/inch2. Combining self-assembly nano-structured
substrates with defined magnetic properties provided by a magnetic film deposited onto the surface,
enable a noble approach to create magnetic nanostructure arrays. We tried to prepare and utilize nanostructured substrates such as silica thin film having self-assembled nano-pores and self-assembled
silica particle substrate.
The Rapid Thermal Annealing (RTA) of Pt/Cu/Fe multilayered continuous films is effective to
obtain perpendicularly magnetized small L10-FeCuPt grains on thermally oxidized Si substrate. We
introduced Rapid Cooling Process into RTA. With the rapid cooling process, growing of grains were
prevented, however new shoulder peak in XRD (X-ray diffraction) profile were appeared at slightly
lower angle of FeCuPt (002) peak and it might be correspond to the disordered structure of FeCuPt.
From electron diffraction patterns and dark field images of single grain by TEM, mostly L10-ordered
polycrystalline structure was observed. Therefore, we preformed additional annealing to above
isolated FeCuPt grains by using same annealing chamber of RTA, for crystallizing those poly-crystal
grains to form single crystalline grains.
Annealing condition was decided as 600 degree C for 1 hour. The ordering temperature of FePt
alloy is ~600 degree C and estimated atomic diffusion length is the order of third nearest neighbor
distance in FePt at the annealing condition. From the comparison of the XRD profiles, the intensity of
(001) super lattice peak which indicate the formation of L10-ordered phase is increased, and the
shoulder peak at slightly lower angle of (002) is banished as shown in Fig. 1. Thus, FeCuPt grains and
are expected to form single crystalline
grains. After additional annealing, grains
kept almost similar size. Furthermore, we
observed crystal structure of a typical single
grain after additional annealing by TEM. In
most of grains, octagonal symmetric shape
is appeared as shown in Fig. 2. From
electron beam diffraction measurement of
Fig. 1 XRD profiles of before and after the additional annealing
the single grain, series of {110} super
lattice and {200} lattice spots are observed
with fourfold-symmetry. {110} spots
indicate the formation of L10-ordered
structure. Thus, the grain consists of c-axis
oriented single crystalline structure from
{110}
complementary results of XRD covering
macroscopic area and localized electron
beam diffraction.
5 nm {200}
As a result, we found that an application
Fig. 2 Bright field image of TEM and Electron diffraction pattern
of adequate additional annealing makes
for an isolated grain after additional annealing.
grains into L10 single crystalline structures
and grains kept almost similar size.
84
Nihon University N.Research Project 2012
Pursuing the Limits of Nanomaterial-based Photonic and Quantum Technologies
Nobuyuki IWATA
Nanomaterials and Nanodevices
1. Induced ferromagnetic-ferroelectric multiferroic materials at room temperature
[ABO3/REMO3](A=Ca,La, B=Fe,Mn, RE=La,Bi, M=Fe,Fe0.8Mn0.2) superlattices were deposited
on surface treated SrTiO3(100) substrates by pulsed laser deposition method; 3 types of CaFeO3(CFO)series, 3 types of CaMnO3(CMO)-series, 3 types of LaMnO3(LMO)-series. In a 2- x-ray
diffraction, satellite peaks and Laue oscillations were clearly observed. Those results indicate that
the homogenous interface is created. From the results of reciprocal space mapping (RSM), all
superlattices except for LMO/BiFe0.8Mn0.2O3(BFMO), cubu-on-cube structure was observed with the
film lattice fitted to the substrate lattice in-plain. Sheet resistance of the superlattices showed
semiconducting behavior. In the case of CFO-series superlattices, the resistance was too high to
measure in our system. Activation energy (EA) and critical temperature (TC), where the slope
changed, are summarized in Table I. The EA of CMO and LMO single layer was 0.076 and 0.17eV at
higher temperature. The EA of the superlatatice was smaller than the value of single layers,
indicating that the electron transfer, intermixing of cation at the interface, and modification of the band
structure. At the TC, magnetic transition is expected. The author did the organizer at the biggest
joint symposium in this field (JSAP-MRS 2012 Spring Meeting). The author was invited to the
OMTAT international conference hold at Kochi, India with the title of Oxides heterostructures for
giant magnetoelectric effect.
Table I : Summary of activation energy (EA) and critical temperature (TC) of superlattices.
REMO3
BiFe0.8Mn0.2O3
BiFeO3(BFO)
LaFeO3(LFO)
(BFMO)
ABO3
Temp. region
Lower
Higher
Lower
Higher
Lower
Higher
Temp.
Temp.
Temp.
Temp.
Temp.
Temp.
CMO
EA(eV)
0.082
0.050
0,034
0.030
0.013
0.19
(0.076eV) TC(K)
151.1
125.6
71.2
LMO
EA(eV)
0.55
0.16
------0.12
(0.17eV)
TC(K)
240.7
----2. Single-Walled Carbon Nanotube (SWNT)
In order to develop a FET property using just one SWNT, substrate heater was redesigned.
Approximately 30 of G/D ratio, which indicates the quality of SWNTs, was extremely improved to be
over 400.
Possible reasons are as follows; carbon source is fully reactive state for introduction to
catalysts, redox catalysts surface is obtained just before CVD deposition, and optimized CVD
condition depending on the catalysts diameter is realized.
The value of G/D ratio was less than 50,
50~100, and over 100 in SWNT with a diameter of 1.1 nm, 1.46 nm, and 1.65 nm, respectively.
There was a relationship between catalysts diameter and CVD condition, in particular heater
temperature, gas pressure, and flow rate of carbon source.
In addition, we found that the chirality
was controllable by free electron laser (FEL) irradiation after start of CVD deposition.
85
Nihon University N.Research Project 2012
Preparation of Metallic Clusters in Solution and Applications to Catalysis
Ken JUDAI
Nanomaterials and Nanodevices
Metallic clusters, which are defined as aggregation compounds of several or hundreds atoms, have
been usually produced in the gas phase. The number of atoms is critical function to describe the
properties of clusters, and the difference of only single atom can cause remarkably changing for
reactivity and stability of the clusters. This indicates that the atomically precise control of cluster size
becomes important for the material applications. In this work, gold clusters, the most stable metal
element for air-oxidation, were prepared in solution phase, and were size-separated. The
electrochemical measurement was also attempted to the gold clusters for catalytic application.
1. Preparation of gold clusters in solution and size separation
The problem on the cluster production with a vacuum chamber in the gas phase is extremely low
yield. Thus, metallic clusters with ligand molecules were prepared in solution and were size-separated
by chemical technique. In detail, tetrachloroauric(III) acid under the presence of phenyl ethane thiol
was reacted with reducing agent. The gold clusters protected by thiol were obtained. The size
exclusion chromatograms are shown for sampling at the periods of 1, 3, 7, 24 hours after the addition
of borane reducing agent.
Although the chromategram at 1 hour has many
peaks to be regarded as
reaction intermediates, the
other
chromatograms
indicate the termination of
chemical reactions. It
should be noted that the
peak at 50 min retention
time has been changing
during 24 hours. The
cluster size might change
in this time scale.
2. Electrochemical measurement for catalysis application
The most stable gold clusters can be isolated by producing condition and careful choice of
extraction solvent. The gold cluster was reduced
by sodium borohydride and was extracted with
acetonitrile. The gold cluster protected by
phenyl ethane thiol, Au25(SR)18, was obtained.
The resulted cluster was casted on the surface of
glassy carbon electrode. The cyclic voltammetry
measurement has been done in sulfuric acid
solution. The different potentials to gold bulk
surface were observed. The catalytic activity
will be examined by this technique for clusters
on the surface.
86
Nihon University N.Research Project 2012
Actin Cytoskelton Dynamics Control Adipocyte Differentiation Via Regulation of MKL1
Koichiro KANO
Medical Group
The hallmark of adipogenesis process is the dramatic alteration in actin cytoskelton as the structure
of filamentous actin is converted from stress fibers to cortical actin. Here, we report that actin
cytoskelton dynamics act as a trigger of adipocyte differentiation. Actin cytoskelton remodeling was
immediately caused via the down-regulation of RhoA/ROCK signaling, which is a prominent
regulator of cytoskeletal dynamics, and this actin remodeling was required for a master regulator
PPAR expression and adipocyte differentiation. Also it was found that the cellular G-actin levels
were rapidly elevated depending on adipocyte differentiation, and increasing G-actin caused
adipogenesis by preventing nuclear translocation of MKL1, which is a transcriptional co-activator.
Moreover, we revealed that MKL1 expression was reduced during adipogenesis, and further only
knockdown of MKL1 could trigger adipocyte differentiation. Besides, PPAR was closely involved in
the down-regulation of MKL1 in a positive feedback manner. Our findings provide new insights to the
regulatory mechanism of adipocyte differentiation that actin cytoskelton dynamics control adipocyte
differentiation via regulation of MKL1, and that MKL1 is a novel repressive regulator of adipocyte
differentiation.
87
Nihon University N.Research Project 2012
Anti-tumor Effect of Inhibition LIT1 Gene Transcription by using as New Therapeutic Agent
Tsugumichi KOSHINAGA
Medical Group(Pediatric Surgery, School of Medicine)
Beckwith-Wiedemann syndrome (BWS) is a human
imprinting disorder with a variable phenotype. The major
features are omphalocele, pre- and postnatal overgrowth,
and macroglossia. BWS predisposes patients to embryonal
tumor (Wilm’s tumor, Hepatoblastomoa) in 5~10% degrees
of patients.BWS is associated with epigenetic alterations in
two imprinting control region, KvDMR and H19DMR, on
chromosome 11p15.5. The absence of methylation in
KvDMR is called loss of imprinting(LOI) and leads to
overexpression of LIT1 gene. This gene down-regulates circumjacent genes including p57KIP2, tumor
suppressor gene. We investigate the association between overexpression of LIT1 gene and
tumorigenesis in BWS. LOI in KvDMR reported to happen in several adult tumors.
On the other hands, PYRROLE-IMIDAZOLE POLYAMIDE(PIP) polyamide can recognize a
specific DNA sequence and bind the minor groove of double strand DNA. If PI polyamide is designed
against a sequence of the target transcription factor binding site, it might artificially down-regulate the
expression of a target gene. We generated PIP binding to
promoter region of LIT1 gene to investigate anti-tumor
effect.
We co-cultured PIP(h-CCAAT1;PI-1, h-CCAAT3;PI-3)
with human BWS fibroblast cell line(BWS6,9). In the same
manner, we administered PI-1,PI-3 to Hepatoblastoma cell
line(HuH6 clone5, HepG2), and Wilm’s tumor cell
line(G401). These tumor cell lines showed de-methylation
status in LIT1 promotor region, they may happen LOI in KvDMR.
After 72hours co-cultured, BWS6,9 significantly showed the down-regulation of LIT1 expression
(p<0.05), compared with untreated cell analyzed by real-time RT-PCR. And, G401 significantly
showed difference the number of alive cells by using WST-8 procedure after 120 hours co-cultured.
G401 also showed the down-regulation of LIT1 expression(p<0.05) compared with untreated cell.
These data suggest that PIP which suppresses LIT1 expression
have anti-tumor effect to tumor with LOI in KvDMR. This PIP
may have possibility to be new therapeutic agents. Now, we
investigate anti-tumor effect of this PIP using G401 xenograft
model mice in vivo. If PIP contracts tumor size in vivo, this PIP
thought to contribute to development of drug discovery.
88
Nihon University N.Research Project 2012
Experimental Studies for Quantum Memory using Neutral Atoms
Takeshi KUWAMOTO
Quantum Information Group
As a next-generation information, communication and computer technology, quantum information
processing is hoped very much. In order to construct scalable quantum processing system, quantum
memory is indispensable. Our aim in this project is establishing the basic technique for materializing
the quantum memory. We especially intend to store the quantum entangled states in neutral atoms.
2. Improvements of coherent light storage system
We improved the coherent-light-storage experimental
system for increasing the storage efficiency of laser light
in Rb vapor. Last year, we achieved the storage
efficiency of 60% at storage time of 5μs. As a result of
various improvements such as optimization of laser
power, its frequency, and Rb cell temperature, the
storage efficiency of laser light was increased to 85% at
storage time of 5μs (Fig. 2).
1. Study for storage of orthogonally entangled photon pairs
Last year, we improved the generation system of orthogonally polarized photon pairs, which are
light source when creating the polarized quantum entangled states in the future. In this year, we
pushed forward to store the photon pairs into rubidium (Rb) atoms enclosed in a glass cell.
We utilize the electromagnetically induced transparency (EIT) to store the photon pairs in atoms.
The photon pairs, which are generated with nonlinear optical crystal, typically have several-hundredGHz frequency expansion. To store the photon pairs, this wide frequency expansion must be
extremely narrowed, because the effective bandwidth of EIT is several MHz. We used two etalons
with different free spectral range for frequency
narrowing the photon pairs. The expected bandwidth
of photon pairs passed thorough them was about 300
MHz.
To verify the bandwidth of photons passed through
two etalons, we observed the absorption of photons
by Rb vapor at various temperatures. FWHM of
absorption spectrum of Rb atoms is typically about
500 MHz. Figure 1 shows the absorption rate of the
photon pairs as a function of Rb vapor temperature.
Fig. 1 Absorption rate of frequency-narrowed
At vapor temperature of 95, 97% of photons was
orthogonally polarized photon pairs by Rb vapor as
absorbed into Rb vapor. This means that the photon
a function of the temperature of vapor.
pairs with several-GHz bandwidth could be
frequency-narrowed by two etalons until 500 MHz level.
We now perform experiments that observe the orthogonally polarized photon pairs passing through
the Rb vapor by EIT effects. Since the transmitted photon pairs have only few-MHz frequency width,
they are suitable quantum correlated photon source for storage in Rb atoms. In future, we will perform
two-photon interference measurements of EIT-transmitted photons, storage of orthogonally polarized
photons in Rb atoms, generation of orthogonally quantum entangled states with orthogonally polarized
photon pairs, and storage of quantum entangled states in atoms.
μ
Fig. 2 Storage of laser light resonant with Rb
atom.
89
Nihon University N.Research Project 2012
Construction of the Escherichia Coli Expression System of the Cell Membrane Permeable iPSCs
Induced Factors That Strengthened Proteolysis Resistance
Yoshikazu MASUHIRO
Medical Group (Department of Applied Biological Sciences, College of Bioresource Sciences)
It is required that the induced pluripotent stem cells (iPSCs) to use for regenerative medicine are
safe hereditarily. As for the current iPSCs derivative method, the virus method is mainstream, but gene
variation is concerned about by this method. Therefore, the derivative method using protein and the
reagent is expected in future. The derivative method with the cell membrane permeable proteins have
been already reported by two groups, but induced efficiency is extremely bad, and there are many
problems (operation and preparations are great). For this reason, it is thought that cell-permeable
proteins are degraded in a cell early. Therefore, in this study, we work on development of iPSCs
induced factor (Oct4, Sox2, Klf4, Glis1) having resistance in the proteolysis in the cell. We try in
particular application (it fuses as a tag) of proteolysis-resistant motif Stabilon which we developed
originally in our laboratory. From a past study, because the Stabilon was effective about Sox2 and
Glis1, we made Stabilon fusion and a non-fusion for these proteins. From the quantity of the
expression and simplicity of purification, we decided that these proteins expressed in Escherichia coli
as an inclusion body. We performed cloning of these factors in pET28a expression plasmid and
produced it in BL21(DE3). Oct4; 3mg, Sox2; 3mg, Sox2-Stabilon; 3 mg, Klf4; 4.5mg, Glis1; 1.2mg
and Glis1-Stabilon; 1.2 mg expressed in BL21(DE3) per 1 liter LB culture media. In addition, we
purified these proteins under guanidine hydrochloric acid and urea (denature condition) from an
inclusion body, and performed refolding by the dialysis. These denature proteins refolded about Oct4;
30%, Sox2; 10%, Sox2-Stabilon; 30%, Klf4; 5%, Glis1; 0% and Glis1-Stabilon; 5%. In addition, we
were able to confirm the DNA binding capacity by Gel shift assay about Sox2, Sox2-Stabilon. We
examine these transcription activity and we introduce it into mouse MEF cell and examine the induced
efficiency of iPSCs in future.
90
Nihon University N.Research Project 2012
Pharmacokinetic/Pharmacodynamic Analysis of Tumor-localizing Photosensitizing Compounds
Takahiko AOYAMA, Yoshiaki MATSUMOTO
Medical Group(College of Pharmacy)
To describe the relationships between effects following photodynamic therapy, light dose, and
plasma compound concentration, we investigate the pharmacokinetics of novel compound CT101019a
(Fig. 1).
1. Pharmacokinetics of CT101019a
To characterize the pharmacokinetics of CT101019a after intravenous administration at various
doses in rats, dose linearity of CT101019a was observed. The plasma concentration-time profiles were
analyzed by a non-compartmental method. The analysis of dose linearity was performed for AUC
using the power model. CT101019a showed nonlinear pharmacokinetics in rats.
2. Development of Pharmacokinetic model predicting human pharmacokinetics for Talaporfin
We develop the pharmacokinetic model of talaporfin (Fig. 2) predicting human pharmacokinetics
using rat, mice and human data. The pharmacokinetic differences among species were modeled by
allometric scaling method. The prediction of rat and human pharmacokinetics had a bias (Fig. 3).
Accordingly, we optimize the model incorporating the physiological parameters such as rate of bile
excretion, hepatic blood flow and plasma volume.
N
O
N
NH
+
N
N
H
N
N
OH
Br
N
Fig. 2 Chemical structure of talaporfin.
Fig. 1. Chemical structure of CT101019a.
Fig. 3. Goodness-of-fit plots for pharmacokinetic model of talaporfin.
91
Nihon University N.Research Project 2012
Self-assembly and Self-organization from the viewpoint of Device-fabrication Methods
Sachiko MATSUSHITA
Supramolecular and Self-Assembly; Energy Technology
Two subjects related with self-assembly and self-organization were studied with perspective of the
developments of unexplored scientific fields and new technology: 1) Dye-sensitized photonic crystal
electrodes, and 2) Fabrication of optical devices via self-assembly.
1. Dye-sensitized photonic crystal electrodes
There are few reports on photoelectric conversion efficiency using naturally-occurring dyes for dyesensitized solar cells (DSSC). This is because the matching with an excited electronic level of
naturally-occurring dye to the conduction band of semiconductor is problematic; the excited electrons
are easily relaxed to the steady state with fluorescence or heat emission. We examined the
fluorescence inhibition effect of a self-assembled photonic crystal using Chlorine e6 dye. Chlorine e6
is derived from chlorophyll and has a long excited electron lifetime.
We prepared TiO2 inverse opals with various particle sizes by liquid phase deposition (LPD) and
described their effect on DSSCs with regard to structural, optical and electrochemical properties. In
addition, we explored the implications of fluorescence lifetime measurements relative to the photonic
band diagram and the amount of adsorbed dye. After these precise experiments, it is possible that the
photonic band influenced the internal quantum efficiency per one dye molecule.
A detailed verification of this assumption cannot be performed for a self-assembled photonic crystal
with many defects. Such verification would require a dye sensitizing electrode with a full/complete
photonic bandgap. To prepare such electrochemical photonic crystal, we also performed the
calculation [1] and fabrication of a photonic crystal structure of (001) rutile TiO2 substrate by deep
reactive ion etching (RIE) using SF6 plasma [2]. The IR spectrum of this fabricated photonic structure
was compared with the photonic band diagram.
2. Noble Planar and Symmetric Nanostructures in Prospective Plasmonic Devices
Noble planar and symmetric nanostructures, such as rod or spiny structures, were prepared by the
combination of colloidal self-assembly, thermal sintering and chemical etching, which enables the
tuning of both size of the particle and neck diameter. As a result, we could fabricate nanostructures on
that six nanorods and tips are arrayed in a planar arrangement on a spherical particle. Localized
surface plasmon resonance was observed from each structure [3]. To evaluate the sensing ability of
structures, SERS was measured. The rod structure showed the biggest SERS effect among our
structures in spite of the smallest amount of Au coating.
[1] S. Matsushita, O. Suavet, H. Hashiba, Electrochim. Acta, 55 (2010) 2398-2403.
[2] A. Matsutani, M. Hayashi, Y. Morii, K. Nishioka, T. Isobe, A. Nakajima, S. Matsushita , Jpn. J.
Appl. Physics, 51 (2012) 098002.
[3] T. Miyamoto, S. Saito, T. Isobe, A. Nakajima, S. Matsushita, Chem. Commun., 48 (2012) 1668.
92
Nihon University N.Research Project 2012
Applied Chemical Biology: Strategy to Cure Cancer Patients
Takayoshi WATANABE, Hiroki NAGASE
Medical Group (Chiba Cancer Center Institute)
Exploiting an enormous amount of potentials of organic chemistry, we have conducted chemical
biological approaches to cure cancer patients. Following two distinct but important approaches have
been studied for the last four years and found promising preliminary results. The first one is DNA
binding molecule of PI polyamide for cancer therapy and the second is a novel chemosensitizing
radiation therapy.
1. PI polyamides targeting cancer related genes for anti-cancer therapy
Pyrrole-Imidazole (PI) polyamide molecule was originally designed from structures of natural DNA
binding molecule, such as Distamicine and Diocarbamicine and has been discovered as a synthetic
molecule which recognizes the minor groove of Watson-Click base pairs of double-stranded DNA in a
sequence-dependent manner. We have developed a semi-automatic synthesis system for PI polyamide,
which are able to regulate specific target gene-expression under specific transcription factor binding
inhibition for biological functional studies and perhaps patient therapy. PI polyamide immediately
penetrated the nucleus in vitro and in vivo without any vehicle. After intra venous injection it rapidly
reduce the serum concentration, delivered to most of tissue cells, excreted to urine or bile juice and did
not metabolize in animals. The PI polyamides, designed for anti-Tgfb1 and anti-MMP9 activity, were
well tolerated, reduced target gene expression and showed therapeutic effects in animal models of
human diseases. For instance, after I.V. administration of anti-MMP9 polyamides, tumor metastasis
was significantly suppressed in the mouse model of human liver metastasis of colon cancer. This new
auto-synthetic chemicals can be designed for many transcriptional regulation of transcripts and applied
to prove many biological hypothesis of transcriptional regulation for cancer research, and may be used
for cancer therapy in the future.
2. A novel chemosensitizing radiation therapy by using synthetic porphyrin derivatives
Photodynamic therapy (PDT) is a medical treatment that uses a photosensitizing chemical and a light
source (long wave length light can reach around 1cm depth of human tissues) to activate the applied
chemical. The result is an activated oxygen molecule that can destroy nearby cells. Precancerous cells
and certain types of cancer cells can be treated by PDT. Cancer cells uptake more of the porphyrin
derivatives and retain the chemicals in a long duration. Thus, the PDT can introduce a cancer cell
specific therapy. We invented the radiation-sensitizing chemical of the porphyrin derivatives, which
can be used for PDT and may also induce photon activation therapy (PAT), provoking the emission of
Auger electrons after inducing a photoelectric effect. X-ray radiation allows for the treatment of
cancers that are deep inside the human body. We observed an induced cancer cell death after
irradiation following administration of the porphyrin derivative. This study orchestrated harmony of
works among medical school, school of pharmacy and college of science and technology.
93
Nihon University N.Research Project 2012
Research for High Density and High Speed Magnetic Recording
- Thermally Assisted Magnetic Recording Applying Near Field Optical Light Katsuji NAKAGAWA
Information (Storage) Group
It is a challenging issue to write magnetic domains on a stable magnetic recording layer for the
future high density magnetic recording technology, because the stable magnetic recording layer for
high density recording is extremely sustainable not only against thermal agitation but also against
recording magnetic field. We study thermally assisted magnetic recording that can enable to write
nano-meter size magnetic domains on stable magnetic film by the technique that applies the confined
laser light by a near field optical method. The research has been collaborated with Assistant Prof.
Ashizawa. The structure of surface plasmon antennas is designed by optical and thermal simulation
collaborated with Associate Prof. Ohnuki. Magnetic films and fabrication e-beam lithography
processes for surface plasmon antenna are also prepared. We have also started femto-second laser
pulse recording collaborated with Associate Prof. A. Tsukamoto and Prof. A. Itoh.
1. Thermally assisted magnetic record applying femtosecond laser with surface plasmon antenna
To study thermally assisted magnetic recording focusing
on surface plasmon effect as well as thermal diffusion
effect, a 90-femto-second laser pulse impinged upon
surface plasmon antennas on Co55Pt30Cr15–SiO2 granular
film. It is important to use a femto-second laser pulse to
analyze those effects, because the effects can be degraded
by the thermal diffusion during the laser pulse duration if a
longer laser pulse is applied. A SiN dielectric inter-layer
was fabricated to keep an accurate distance between the
antennas and the granular film. Written magnetic domains
caused by surface plasmon effect were clearly observed by
a magnetic force microscope. The minimum domain
corresponded to 166 nm × 120 nm in size even though the
laser spot diameter was about 50 μm. The surface plasmon
effect was evaluated by the Finite-Difference TimeDomain method, and the thermal diffusion effect was also
calculated to study thermally assisted magnetic recording.
2. Combination of dielectric waveguide and surface
plasmon polariton
It is very important how to locate surface plasmon
antennas in magnetic head for thermally assisted magnetic
recording. We studied the dependence on energy transfer
efficiency to get high efficiency. One of the methods that
surface plasmon antennas are placed along with a
waveguide was investigated by simulation. It is revealed
that a confined circularly polarized light can be created by
this method.
94
(a)
Applied electric field
direction of light
Au antennas
5 µm
(b)
5 µm
F ig. 1 The surface morphology (a) and the
magnetic domains (b) after a 90 fs laser pulse
train was exposed over the entire surface of
the Co55Pt30Cr15 – SiO2 granular film. The
applied Au plasmon antennas were 35 nm in
thickness, and their width and length were
nearly 100 nm and 1 µm, respectively.
Nihon University N.Research Project 2012
Development of Photonic to Chemical Energies Transformation Systems
Nobuyuki NISHIMIYA
Energy Technology
Several processes that transform photonic energy to chemical energies such as hydrogen energy
have been studied through separation and recovery of hydrogen by means of hydrogen occluding
alloys from low purity hydrogen produced by microorganisms on photosynthetic reactions and from
hydrogen mixtures produced by hydrogen fermentation as well as through designing and preparation
of hydrogen occluding composites imparted with photocatalytic activities. Specification of the active
entities of hydrogen fermentation of practically employable microorganism mixtures established at the
Tanisho Laboratory of Yokohama National University and enhancement of hydrogen storage by nanosized layer compounds composed of boron, carbon and/or nitrogen have been concentrated.
1. Specification of microorganisms of hydrogen fermentation
Hydrogen fermentation by the well-selected microorganism mixture established at the Tanisho
Laboratory of Yokohama National University was permitted to evolve 1 L STP of hydrogen an hour,
and the entity of the hydrogen fermentation was analyzed to specify the identification of the
microorganisms. Conventional procedures are apt to fail to specify the very active entities due to the
possibly poor growth rate of the essential microorganisms. An improved procedure was thus
employed comprising abstract of DNA from the well-selected microorganism mixture, enhancement
of 16S rDNA by PCR (Polymerase Chain Reaction), separation of the specified 16S rDNA by DGGE
(Denaturing Gradient Gel Electrophoresis) and reading the arrangement of DNA bases. Several
microorganism species have been identified based upon DDBJ (Japanese database on DNA).
2. Separation and recovery of bio-hydrogen by magnesium-based alloys
Additional use of soft sol-gel encapsulated Mg-10%Ni/NbF5 composite was attempted and
hydrogen recovery from Spirulina vial was performed by much less amount of the hydrogen occlusion
material. While the amount of the material was reduced by half, the encapsulation was not complete
as detected by a detectable reaction of Mg with water. Completion of the encapsulation and further
reduction of the weight are to be attained.
2.5
Hydrogen content / mass%
3. Hydrogen storage by grapheneBN
Ni modified C
derived carbon nano-balls
2
Pt modified CN
Carbon nano-balls were prepared by
1.5
CN
separation of graphene sheets from
Pd modified BN
C
graphite as proposed by Hummers,
1 Pd spray
modified
S
agglomeration of oxidized graphene
BN
E
0.5
sheets around metallic cores and
reduction of ball-like agglomerates
Pd modified CN
0
under hydrogen. Larger amounts of
0
200
400
600
800
1000
hydrogen were adsorbed on surfaces
2 -1
Specific surface area / m g
inside the mesopores of the nano-balls
Figure 1Variation of hydrogen storage capacity at 77 K and
than those on even graphitic surfaces.
0.8 MPa with specific surface area
4. Hydrogen storage by nano-sized layer compounds composed of boron, carbon and/or nitrogen
Among the B-C-N phases that do not contain substantial amounts of rare metals, BN and C3N4 (CN
in Figure 1) were found promising as positively deviated from the theoretical line in Figure 1.
95
Nihon University N.Research Project 2012
Nano-Electromagnetic Simulation and Its Applications to Plasmonic Devices
Shinichiro OHNUKI
Quantum Theory and Computation Group
This work aims at developing fast and reliable electromagnetic simulation methods for studying
interaction between light and nanoscale objects. We apply our computational methods to designing
nanoscale devices through the collaboration with researchers of the N. research project.
1. Design of Plasmonic Antennas with Particulate Media for All Optical Magnetic Recording
We have designed plasmonic antennas to generate the localized circularly polarized light inside the
bit-patterned media for realizing ultra-high density magnetic recording. Using the ADE-FDTD method,
the generation time and intensity of the localized circularly polarized light are clarified in terms of the
combination of antennas.
2. Time Domain Responses of Electromagnetic Fields by Integral Equation Methods
We have developed novel fast and accurate solvers based on integral equation methods with fast
inverse Laplace transform for time domain electromagnetic problems. The advantages of our proposed
method are (1) the computational error is easy to be controlled, (2) there is the no restriction of
selecting time step size, and (3) an arbitrary observation time can be selected. Using our proposed
method, we analyze time domain responses of electromagnetic fields near nanoscale antennas and
dipole moments of molecular motors.
3. Multiphysics Simulation of a Nanoplate in Laser Fields
A nanoplate in laser fields has been analyzed by the coupled Maxwell-Schrödinger scheme which
is based upon the FDTD method. We have investigated the current densities and electromagnetic
fields near the nanoplate in terms of tunneling effects due to well structures. Advantages of our
proposed method are clarified in comparison with conventional classical solvers.
4. Modeling of Plasmonic Waveguides for a High Sensitivity Optical Sensor
We have proposed an optical sensor which consists of a metal stripe and nano wire inside an
optical fiber. Using the proposed device, electromagnetic energy is concentrated around the metal
stripe and the energy can be efficiently absorbed into the nano wire. We verity that the
electromagnetic energy inside the nano wire becomes three times larger than that for the case without
the plasmonic waveguide.
5. High-Precision Analysis of Electromagnetic Scattering Problems
To obtain reference solutions for electromagnetic canonical problems, we have developed a mode
matching method. The method has been proposed for a dielectric sphere with a metal shell as an
example of 3D canonical geometries. Scattered electromagnetic fields are analyzed and computational
error is confirmed.
+
y
x
Jy [A/m2]
z
Ey
Hz
+
1
0.8
0.6
0.4
0.2
0
-0.2
-0.4
-0.6
-0.8
-1
[1015]
Maxwell-Newton
Maxwell-Schrödinger
0
100
200
300
400
t [fs]
Figure 2 Time response of the current density.
Figure 1 Coordinate systems of the nanoplate.
96
Nihon University N.Research Project 2012
Self-Assembled Supramolecules and Their Applications to Energy, Medical, and Information
Technologies
Joe OTSUKI
Supramolecular and Self-Assembly Group; Energy Technology Group
Self-assembly of appropriately designed molecules will afford a bottom-up method for producing
nanostructures. This work aims at developing new molecular self-assembling systems, revealing selfassembled structures and dynamic behaviors at the molecular level, and searching for applications of
self-assembly to energy, medical, and information technologies through the collaboration with
researchers of the N. research project.
1. Self-Assembly of Molecules and Quantum Dots
The low-density solar radiation is efficiently collected by lightharvesting antenna made of self-assembled chlorophyll molecules,
where highly-efficient excited energy transfer processes take place.
Such structures, if we could construct by design, would be used in
artificial photosynthetic systems and organic photovoltaics. We
have found that pyridine-appended chlorophyll molecules form
double helical structures, which was revealed by the single crystal
X-ray crystallography, reminiscent of the double helices of DNA
(Figure 1). While an oxazole-appended chlorophyll derivative
leads to a stair-case type architecture. These works constitute a
step toward constructing artificial antenna systems based on
molecular assemblies.
In the field of molecular assembly, we revealed the arrangement
and behaviors of a double-decker type porphyrin complex on a
substrate surface at the molecular scale [J. Nanosci. Nanotechnol.
2012, 12, 159].
We are also working on the preparation of quantum dots,
entrapment of the quantum dots in silica coatings, and fabrication
of ordered assemblies of the silica-coated quantum dots. The series
of techniques will be used in devices for quantum cryptography.
Coating with silica without deteriorating the high quantum yield of
emission of quantum dots is the bottleneck at present, which is the
main focus of our ongoing work.
2. New Dyes for Dye-Sensitized Solar Cells
We have prepared new dyes based on donor-substituted perylene
dicarboxylic derivatives, in which the donors, the side arms, and
the adsorption sites to the TiO2 electrode were varied. No new dyes, Figure 1. Double helix
formed by a chlorophyll
however, exceeded previously reported our record of 3.1%. Some
derivative.
new ruthenium-based complexes were also prepared and their
structures and properties were revealed.
In relation to photovoltaics, we studied some aspects of graphene oxide, which is a promising
substitute for widely used ITO electrode. We successfully prepared reduced graphene oxide thin films
with good electrical properties under heat treatment with temperature lower than reported [Appl. Surf.
Sci. 2012, 259, 460; Appl. Nanosci. 2012, DOI 10.1007/s13204-012-0144-2].
97
Nihon University N.Research Project 2012
Comparison of the structure of conjugate Fermi holes in He-like systems and artificial atoms
Tokuei SAKO
Quantum Theory and Computation group
Controlling electronic properties of nanomaterials requires our deep understanding in the
behavior of electrons confined in nano-scale objects. Through the continuing research of this N.
project we have found last year the existence of the so-called conjugate Fermi hole in the wave
function of two electrons with antiparallel spins. This year we have focused on artificial atoms or
quantum dots and have examined in detail the structure of conjugate Fermi holes in the systems. As a
consequence of the analysis, the origin of the first Hund rule in artificial atoms has been rationalized,
and the difference in the mechanism operating in artificial atoms and in the corresponding He-like
systems has been clarified.
Empirically derived Hund's rules of the prequantum-mechanics era predict the ordering of the
energy levels possessing different spin and orbital
angular momentum quantum numbers. They have proved
to be almost universally valid for atoms, molecules, and
quantum dots. Yet, despite of a long standing debate the
search for their origin persists, primarily due to the lack
of the precise knowledge of the electronic structure in
different spin states. We explore the origin of the first
Hund rule for a two-dimensional model of He-like
systems and that of two-electron quantum dots. They
represent ideal systems providing a direct fundamental
insight into the structure of the internal part of the fullycorrelated wave functions, allowing an unambiguous
argument. An examination of their probability density
distributions reveals indeed the existence of a region in
the internal space which we refer to as a conjugate Fermi
hole. In this region the singlet wave function has a
smaller probability density than the corresponding triplet
one, in contrast to the genuine Fermi hole where the
triplet has a smaller density than the singlet. Due to the
presence of this conjugate Fermi hole the singlet
probability density has to migrate far away from the
center of the one-electron potential. This rationalizes the
well-known broader electron density distribution of the
singlet state relative to the corresponding triplet. This
key observation explains the singlet-triplet energy gap.
Structure of the genuine and conjugate Fermi
holes in the internal space for the (1s)(2p)
singlet-triplet pair of states of He-like systems:
(a) – (c) correspond to the nuclear charge Zn of
20, 5, and 2, respectively. (a’) – (c’) represent
the electron repulsion potential for the
corresponding Zn.
The results of this study has been published as an regular article in Journal of Physics B, which has
been selected as an IOP Select paper for its “significant breakthrough and high impact” [1]. Moreover,
this content of this paper will be covered by Europhysics News of its January issue in 2013 [2].
[1] T. Sako et al., J. Phys. B, 2012, 45, 235001(13 pages).
[2] T. Sako et al., Europhysics News, to appear in January issue (2013).
98
Nihon University N.Research Project 2012
Synthesis of Nano-rod Devices with Wide Band Gap Semiconductor Effect
Kaoru SUZUKI
Nanomaterials and Nanodevices Group
My research aims at fabrication of nano-materials and nano-devices for high functional applications
such as nano-tube sensor, nano-rod transistor and wide band gap semiconductor nano-film for watersplitting by using fundamental techniques of nano-process and fabrication of nano-materials. Using
the achievement of the investigation, progress of energy conversion system, information technology
and biotechnology can be expected.
Metal encapsulated carbon nanotube for magnetic force microscope probes
1.
We have synthesized directly ferromagnetic metal (Ni) and composition metal encapsulated carbon
nanotubes (CNTs) for probe of magnetic force microscope or spin device on a mesh grid for viewing
transmission electron microscope (TEM) by pyrolysis of ethanol solution. These metals inside CNTs
identified Ni and SUS with energy dispersive X-ray (EDX) spectrum analysis. The diameter and
length of the metal core is in the range of 10 – 80 nm and 100 – 800 nm with varying heating period
and temperature, respectively. The walls consist of cylindrical graphene sheets with 3 -50 layer.
2. Creation of carbon nano-tube/fiber and diamond-like carbon circuit
We have synthesized phosphorus doped n-type carbon nano-tube/fiber by Joule heating on
ethanol/Si surface, and diamond-like carbon films by ion beam plating method. Type of p-n junction
diode and wiring were created by focused Ga+ ion beam injection.
3. Synthesize of photocatalytic SrxLa1-xTiO3 film for hydrogen generation on polymer films
with visible area in solar light excitation by laser induced forward transfer method
La doped TiO2 have attracted great interest for photocatalytic properties, which can be used visible
area in solar light although only TiO2 limiting with ultra violet area. We have successfully crystallized
perovskite structure films which were La doped TiO2 thin film of La2Ti2O7, Sr doped TiO2 thin film
of SrTiO3 and both impurity doped thin film of SrxLa1-xTiO3 (x=0.1~0.9). Now, we try to deposit of
TiO2 on polymer films by laser induced forward transfer method.
Synthesis of ZnO nano-films for light emitting device by infrared light excited pulsed laser
4.
deposition method
We have synthesis nitrogen doped p-type ZnO nano-films by infrared light excited pulsed laser
deposition method. High quality crystalline of p-type ZnO nano-films were improved by pulsed
YAG laser annealing below 532 nm of laser wavelength.
Bio-electronics
5.
We have studied the sterilization of periodontal bacterium by atmosphere pressure low frequency jet
plasma; fresh plasma, and splintering/regeneration of enchytraeus japonensis by irradiation of free
electron laser.
Green technology
6.
We have studied the evolution of controlled nano/micro bubble by laser/focused ion beam
fabricated nozzle on piezoelectric vibrator for defecation of water.
99
Nihon University N.Research Project 2012
The Development of Newly Molecular Targeting Drug
for Prostate Cancer by using PI Polyamide
Daisuke OBINATA, Satoru TAKAHASHI
Medical Group (Department of Urology, School of Medicine)
Under the close collaboration with Noboru Fukuda, Masayoshi Soma, and Kyoko Fujiwara, we
have been developing new molecular targeting drug by PI polyamide for cancer therapy.
A recurrent fusion of TMPRSS2 with E26 transformation-specific (ETS) family genes were found
in about 80% of prostate cancer tissues. ETS genes are transcription regulators, and altered expression
or properties of them affect the control of transcriptional processes. Those alterations also could cause
development and progression of cancer. Since TMPRSS2, 5’-fusion partner, was upregulated by
androgen, AR has been supposed to be important to regulate the fusion genes in the prostate cancer.
Aberrant overexpression of ERG induced by TMPRSS2-ERG fusion is likely to be involved in
prostate cancer development. Moreover, recent studies have shown that ligand-dependent binding of
AR to intronic binding sites near the specific tumor translocation breakpoints (TGT/AGGGA/T)
caused facilitating DNA double-stranded break (DSB) generation.
Pyrrole–imidazole (PI) polyamides are small synthetic molecules that recognize and attach to the
minor groove of DNA, followed by inhibition DNA–protein interaction with high affinity and
sequence specificity. Synthetic PI polyamides recognize and attach to the minor groove of DNA with
high affinity and specificity.
Here, we examined the effects of a PI polyamide targeting TMPRSS2-ERG translocation
breakpoints (Fusion Polyamide) on prostate cancer. First, to determinate the binding affinity and
specificity of polyamide to target DNA, gel mobility shift assays were performed. The fusion
polyamide showed selective DNA binding ability. Human prostate cancer cell line treated with Fusion
Polyamide was compared with those with Negative control polyamide. Treatment of Fusion
Polyamides showed significant decreased both DHT induced TMPRSS2-ERG and endogeneous ERG
expression, as well as cell growth and migration. These results demonstrate that PI polyamide
targeting these breakpoints sequences may be a new therapeutic intervention in prostate cancer.
We are now trying to the animal experiment using a nude mouse for elucidating anti-tumor efficacy
in vivo. 100
Nihon University N.Research Project 2012
Mechanism of Superconductivity in Layered Fe-based Superconductors and Search of
New Superconducting Compounds
Yoshiki TAKANO
Nanomaterials and Nanodevices Group
Since LaFeAsO1-xFx was discovered to be a superconductor in 2008, many iron-based
superconductors have been found. Among them, SrFeAsF is called 1111-superconductor and its crystal
structure is as same as that of LaFeAsO. When a part of Sr site is substituted by rare earth ions, the
superconductivity occurs. In 2010, RFeAsO1-y (R=La, Nd) are also reported to be a superconductor.
Then, we have prepared Sr1-xRxFeAsF1-y (R = La, Nd, Sm) and investigated their superconducting
properties. Furthermore, we have investigated the possibility of Sr1-xNdxFeAsF for the superconducting
wire rod. On the other hand, LiFeAs is called 111-superconductor and is a superconductor with Tc of
18 K itself, which is different from other superconductors. Then, we have tried to prepare LiFe1-xCoxAs
and Li1-xYxFeAs and investigated their electrical properties.
2.5
Nd
2.0
Sm
n
La
1.5
1.0
0.5
0
0.15
y
0.30
Fig.1 The relation n vs. y.
2.5
2.0
1.5
n
1. Superconducting Properties of Sr1-xRxFeAsF1-y (R=La, Nd,
Sm)
The temperature dependence of the electrical resistivity in the
normal region is analyzed by a power law such as r (T)=r 0+ATn,
where r 0 is the resistivity just above Tc. Figure 1 shows the
relation between n and y of Sr1-xRxFeAsF1-y ; x = 0.4 for R = La
and x = 0.5 for R = Nd and Sm. As F deficiency y increases, n
increases. This result is different from the previous study.
Figure 2 shows the relation between n and Tc of Sr1-xRxFeAsF1-y.
As n increases, Tc decreases. Similar tendency is observed in
other iron-based superconductors. It is independent of R ions.
While the superconductivity is observed up to y = 0.15 for Sr1(low Tc compound), the superconductivity
xLaxFeAsF1-y
disappears at y = 0.05 for Sr1-xRxFeAsF1-y (R = Nd, Sm) (high Tc
compound). n increases rapidly for Sr1-xRxFeAsF1-y (R = Nd,
Sm) in a small y region and it is gradually increases with y for
Sr1-xLaxFeAsF1-y.
The upper critical magnetic field of Sr0.5Nd0.5FeAsF is higher
than that of MgB2 that has the highest critical current density.
1.0
2. Preparation and Superconductivity of LiFe1-xCoxAs and
0.5
Li1-xYxFeAs
20 25 30 35 40 45
The 111 phases are obtained as main phase. Lattice constants a
Tc[K]
and c were 3.770Å and 6.358Å for LiFeAs, 3.773Å and 6.350
Å for LiFe0.98Co0.02As, and 3.772Å and 6.333 Å for
Fig. 2 The relation n vs. Tc .
Li0.9Y0.1FeAs, respectively. As FeAs is observed as impurities
phase, Li is considered to slightly evaporate during sample
preparation. Tc of LiFeAs is 10.8K which is smaller than the reported value. Tc of LiFe0.98Co0.02As is
9.5 K and Tc decreased with increasing Co concentration. Li0.9Y0.1FeAs does not show
superconductivity above 3 K and the electrical resistivity of normal state also increased.
101
Nihon University N.Research Project 2012
Ultra Fast Information Recording and Ultra Fast Photo Magnetic Switching
Arata TSUKAMOTO, Akiyoshi ITOH
Information Storage; Supramolecules and Self-Assembly
The ever increasing the capacity of storing information motivates the search for faster approaches to
process and magnetically record information. Most computers store data on magnetic hard disk drives,
in which the direction – “up” or “down” – of the magnetic moments in a small region of the disk
corresponds to a binary bit. However, it was faced to unavoidable fundamental problem for faster
operation in conventional way known as ferromagnetic resonance limit. We have experimentally
demonstrated that an excitation of magnetization reversal phenomena can be triggered by the ultrashort pulsed laser irradiation. This finding reveals an ultrafast and efficient pathway for writing
magnetic bits. Based on deep understanding of relationship between light and magnet including above
new discovery, we are striving to establish the fundamental techniques of researching and developing
ultrafast spin manipulation.
It has been unexpectedly found that the ultrafast laser-induced spin reversal in GdFeCo, where spins
are coupled antiferromagnetically, occurs by way of a transient ferromagnetic-like state (Nature 2011).
Such a novel strongly non-equilibrium spin dynamics may lead to yet unexplored magnetization
reversal. We found that magnetization reversal could be achieved without any magnetic field, using an
ultrafast thermal energy load alone (Nature communications 2012). Until now it has been generally
assumed that heating alone, not represented as a vector at all, cannot result in a deterministic reversal
of magnetization, although it may assist this process. We found experimentally deterministic
magnetization reversal in a ferrimagnetic GdFeCo driven by an ultrafast heating of the medium
resulting from the absorption of a sub-picosecond laser pulse without the presence of a magnetic field.
Fig. 1 shows magneto-optical image of magnetic domains after single pulse laser irradiations.
Subtracted (difference of each sets of images) images shows various magnetic domain was reversed in
same areal size by laser irradiation for all the cases. To exclude the possibility of artifacts caused by
dipolar
interactions
from
surrounded magnetic material,
arrays of 2 μm diameter disks
were fabricated as Fig. 2. The
size was chosen so that the
structures are much smaller than
the laser spot size. The
magnetization
reversal
phenomenon was successfully
confirmed. A further set of
Fig. 1 (a) Magneto-optical image of magnetic domains after single pulse laser
experiments shows that this
irradiations. (b)Subtracted (difference of each sets of images) images.
switching occurs independently
of polarization and initial state
in thin films of GdFeCo.
Importantly for technological
applications,
we
show
experimentally that this type of
switching can occur when
Fig. 2 XMCD images of arrays of 2 μm diameter GdFeCo disks after single
starting at room temperature.
pulse laser irradiations (Nature communications 2012)
102
Nihon University N.Research Project 2012
Distribution of Energy Flow by Dielectric Waveguide with
Rhombic Dielectric Structures along a Middle Layer
–Case of Compared with Deformed Rhombic Dielectric Structure–
Tsuneki YAMASAKI
Quantum Theory and Computation Group
We have analyzed the guiding problem by dielectric waveguides with defects composed of dielectric circular
cylinders array and deformed rhombic dielectric structure in the middle layer and investigated the influence of
energy flow for defect area by using the propagation constants at the guided region. From the numerical results,
it is shown that we can be obtained the confinement efficiency by rhombic dielectric structure compared with
deformed rhombic dielectric structures in the middle layer for both TE0 and TM0 modes.
These results have beenReferenceas follows:
Referencee
1) R. Ozaki and T. Yamasaki: “Distribution of Energy Flow by Dielectric Waveguide with Rhombic Dielectric
Structure along a Middle Layer -Case of Compared with Deformed Rhombic Dielectric Structure-”, IEICE
Trans. Electron., vol.E96-Ccno.1, 2013, (to be published).
1) R. Ozaki and T. Yamasaki e Propagation Characteristics of Dielectric Waveguides with Arbitrary
Inhomogeneous Media along the Middle LayercIEICE Trans. Electron.cvol.E95-Ccno.1cpp.53-62c
2012d
2) R. Ozaki and T. Yamasaki: Distribution of Energy Flow by Dielectric Waveguide with Rhombic Dielectric
Structure along a Middle Layer, IEICE ELEX., vol.9, no.7, pp.698-705, 2012.
1) R. Ozaki and T. Yamasaki e Propagation Characteristics of Dielectric Waveguides with Arbitrary
Inhomogeneous Media along the Middle Layer (Part II)cProc. Progress in Electromagnetic Research
Symposium in Kuala LumpurcMarch 27-30c2012d
2) R. Ozaki and T. Yamasaki e Propagation Characteristics of Dielectric Waveguides with Arbitrary
Inhomogeneous Media along the Middle Layer (Part III) cProc. Progress in Electromagnetic Research
Symposium in MoscowcAugust 19-23c2012d
3) R. Ozaki and T. YamasakiePropagation Characteristics and Distribution of Energy Flow by Dielectric
Waveguide with Arbitrary Inhomogeneous Media in the Middle Layer c Proc. 14th International
Conference on Mathematical Method in Electromagnetic Theory in Kharkiv UkrainecPl1-2cpp.9-17c
August 28-30c2012d
4) R. Ozaki and T. YamasakieDistribution of Energy Flow by Dielectric Waveguide with Rhombic Dielectric
Structure along a Middle LayercProc. International Symposium on Antennas and Propagation in Nagoyac
3D3-2cpp.955-958cOct.29- Nov.2c2012d
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1.
Ze 24 [ 6 s 26 q¼0%1*.+"1¼¸zG¾H· 4 µ
:©V¼Dr. M. Sahabul Alam (University of Dhaka, Bangladesh; Visiting
Researcher of Nihon University) "Supramolecular Nanoarchitectures —
Novel Functional Materials for Molecular Electronics”
2.
Ze 24 [ 7 s 23 q¼0%1*.+"1¼¸zG¾H· 4 µ
:©V¼Dr. M. Sahabul Alam (University of Dhaka, Bangladesh; Visiting
Researcher of Nihon University) "Structural and Transport Properties of
One-Dimensional
Coordination
Polymers
and
Spin
Cross-Over
Complexes"
3.
Ze 24 [ 9 s 15 q¼¿MqvPU N.0),¼
1.
qPDK3jN.'/
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Ze 24 [ 10 s 1 q¼iL+"1¼yx?wn
U012 µ+"1V¼Yu-Xiang Zheng lk(Key Laboratory of
0),
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Micro and Nano Photonic Structures, Ministry of Education, Department of
Optical
Science
and
Engineering,
Fudan
University,
Shanghai,
China) ”Development of ellipsometry and its applications in nanoscale
materials”
5.
Ze 24 [ 10 s 5 q¼iL+"1¼yx?wn
U012 µ+"1V¼Yu-Xiang Zheng lk(Key Laboratory of
Micro and Nano Photonic Structures, Ministry of Education, Department of
Optical
Science
and
Engineering,
Fudan
University,
Shanghai,
China) ”Folded spectrometer and its application in optical monitoring for
thin film deposition”
6.
Ze 24 [ 10 s 17 q¼iL+"1¼yx?wn
U012 µ+"1V¼Andrei Kirilyuk lk(Radboud University
Nijmegen, The Netherland) ”Laser-induced magnetization dynamics and
reversal: the role of angular momentums”
7.
Ze 24 [ 10 s 26 q¼iL+"1¼yx?wn
104
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.ZÐAndrei Kirilyuk qn(Radboud University
Nijmegen, The Netherland)
8.
ak 24 b 11 z 12 vÐ,".%*&
.ÐÍH 8 IÌ 831
qZÐDr. Gary RichardsÐCollege of Science and Technology, Nihon
University “Pyrazinacenes: Synthesis and Self-Assembling Properties of
Nitrogen-Rich Acene Analogues”
9.
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Joint
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“Nanocomposites,
Nanostructures and Heterostructures of Correlated Oxide Systems”
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1.
T. Onchi, Y. Liu, M. Dreval, D. McColl, S. Elgriw, D. Liu, T. Asai, C. Xiao
and A. Hirose, “Effects of compact torus injection on toroidal flow in the
STOR-M tokamak”, Plasma Physics and Controlled Fusion 2013 (to be
published in Jan. 2013).
2.
T. Asai, M. Yamazaki, H. Tomuro, H. Itagaki, M. Inomoto, To. Takahashi,
“Generation of a Magnetized Plasma Shield by Means of a Rotating
Magnetic Field for Innovative Space Transportation”, Trans. JSASS 2012,
10, ISTS28, Pc_73-Pc_78.
3.
T. Ii, K. Gi, T. Umezawa, T. Asai, M. Inomoto, and Y. Ono, “Development
of a low-energy and high-current pulsed neutral beam injector with a
washer-gun plasma source for high-beta plasma experiments”, Review of
Scientific Instruments 2012, 83, 083504 1-5.
ºr
105
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
1.
Y. Koide, H. Ikake, Y. Muroga and S. Shimizu, “Effect of the cast-solvent
on the morphology of cast films formed with a mixture of stereoisomeric
poly(lactic acids)”, Polym. J., 2012, doi: 10.1038/pj.2012.192,
http://www.nature.com/pj/journal/vaop/ncurrent/full/pj2012192a.html.
1.
H. Ishida and A. Liebsch, “Coulomb blockade and Kondo effect in the
electronic structure of Hubbard molecules connceted to metallic leads: A
finite-temperature exact-diagonalization study”, Physical Review B 2012,
86, 205115 (13 pages).
1.
T. A. Ostler, J. Barker, R. F. L. Evans, R. Chantrell, U. Atxitia, O.
Chubykalo-Fesenko, S. El Moussaoui, L. Le Guyader, E. Mengotti, L. J.
Heyderman, F. Nolting, A. Tsukamoto, A. Itoh, D. Afanasiev, B. A. Ivanov,
A. M. Kalashnikova, K. Vahaplar, J. Mentink, A. Kirilyuk,Th. Rasing and
A. V. Kimel, "Ultrafast Heating as a Sufficient Stimulus for Magnetization
Reversal in a Ferrimagnet", Nature Communications, 2012, 3, 666 (pp. 1-6).
2.
K. Vahaplar, A. M. Kalashnikova, A. V. Kimel, S. Gerlach, D. Hinzke, U.
Nowak, R. W. Chantrell, A. Tsukamoto, A. Itoh, A. Kirilyuk, and Th.
Rasing, "All-optical magnetization reversal by circularly-polarized laser
pulses: Experiment and multiscale modeling", Physical Review B 2012, 85,
104402(pp. 1-17).
3.
A. R. Khorsand, M. Savoini, A. Kirilyuk, A.V. Kimel, A. Tsukamoto, A.
Itoh, and Th. Rasing, "Role of Magnetic Circular Dichroism in All-Optical
Magnetic Recording", Phys. Rev. Lett. 2012, 108, 127205-(pp.1-5).
4.
L. Le Guyader, S. El Moussaoui, M. Buzzi, R. V. Chopdekar, L. J.
Heyderman, A. Tsukamoto, A. Itoh, A. Kirilyuk, Th. Rasing, A. V. Kimel,
and F. Nolting, "Demonstration of laser induced magnetization reversal in
GdFeCo nanostructures", Appl. Phys. Lett. 2012, 101, 022410.
5.
R. Medapalli, I. Razdolski, M. Savoini, A. R. Khorsand, A. Kirilyuk, A. V.
Kimel, Th. Rasing, A. M. Kalashnikova, A. Tsukamoto, and A. Itoh,
"Efficiency of ultrafast laser-induced demagnetization in GdxFe100xyCoy
alloys", Phys. Rev. B 2012, 86, 054442(pp. 1-7).
6.
M. Savoini, R. Medapalli, Koene, A. R. Khorsand, L. Le Guyader, L. Du`o,
M. Finazzi, A. Tsukamoto, A. Itoh, F. Nolting, A. Kirilyuk, A. V. Kimel,
and Th. Rasing, "Highly efficient all-optical switching of magnetization in
GdFeCo microstructures by interference-enhanced absorption of light",
Phys. Rev. B 2012, 86, 140404(R)(pp. 1-5).
7.
T. Ubana, A. Tsukamoto, and A. Itoh, "Single crystalline isolated grains of
L10-ordered FeCuPt prepared by combination of Rapid Thermal Annealing
with rapid cooling and additional annealing", Journal of Magnetics
(submitted).
1.
G. Fujii, T. Segawa, S. Mori, N. Namekata, D. Fukuda, and S. Inoue,
“Preservation of photon indistinguishability after transmission through
surface-plasmon-polariton waveguide”, Opt. Lett. 37 (9), 1535-1537 (2012).
2.
S. Arahira, N. Namekata, T. Kishimoto, and S. Inoue, “Experimental studies
in generation of high-purity photon-pairs using cascaded (2) processes in a
106
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
3.
periodically poled LiNbO3 ridge-waveguide device”, J. Opt. Soc. Am. B 29
(3), 434-442 (2012).
G. Fujii, Daiji Fukuda, Takayuki Numata, Akio Yoshizawa, Hidemi
Tsuchida, and Shuichiro Inoue, “Thin Gold Covered Titanium Transition
Edge Sensor for Optical Measurement”, J. Low Temp. Phys. 167 (5-6),
815-821 (2012).
1.
Nobuyuki Iwata, Takuji Kuroda and Hiroshi Yamamoto, “Mechanism of
Growth of Cr2O3 Thin Films on (1-102), (11-20), and (0001) Surfaces of
Sapphire Substrates by Direct Current – Radio Frequency Magnetron
Sputtering”, Jpn. J. Appl. Phys. 51 (2012) 11PG12-1~9 (9 pages).
2.
Hiroshi Yamamoto and Nobuyuki Iwata, “C60 Photo-Polymerization using
Free Electron Laser”, Trans. Mater. Res. Soc. Jpn. 20th Anniversary Special
Issue (2012) 35-40.
3.
Nobuyuki Iwata, Yuta Watabe, Yoshito Tsuchiya, Kento. Norota, Takuya
Hashimoto, Mark Huijben, Guus Rijnders, Dave H. A. Blank, and Hiroshi
Yamamoto, “Growth and Evaluation of [AFeOx/REFeO3] (A=Ca, Sr,
RE=La, Bi) Superlattices by Pulsed Laser Deposition Method Using High
Density Targets Prepared by Pechini Method”, Mater. Res. Soc. Symp. Proc.
1454 (2012) p.161-166.
4.
Nobuyuki Iwata, Takuji Kuroda and Hiroshi Yamamoto, “Crystal Structure
Analysis of the Cr2O3 thin films”, Mater. Res. Soc. Symp. Proc. 1454
(2012) p.33-38.
5.
N. Iwata, Y. Watabe, Y. Tsuchiya, K. Norota, M. Huijben, G. Rijnders,
Dave H. A. Blank, and H. Yamamoto, “Growth of [CaFeOx/BiFeO3]
superlattice by Pulsed Laser Deposition Method Using High Density Target
Prepared by Pechini Method”, Trans. Mater. Res. Soc. Jpn. 37 (2012)
381-384.
6.
Takuji Kuroda, Nobuyuki Iwata, and Hiroshi Yamamoto, “Investigation of
Crystal Growth of the Cr2O3 thin films on Sapphire Substrates”, Trans.
Mater. Res. Soc. Jpn. 37 (2012) 385-388 .
7.
Yoshito Tsuchiya, Kento Norota, Yuta Watabe, Takuji Kuroda, Nobuyuki
Iwata, Takuya Hashimoto, Hiroshi Yamamoto, “Growth Difference of
LaFeO3 Thin Films by Pulsed Laser Deposition Method Using the Targets
Prepared by Pechini and Conventional Solid Solution Methods”, Trans.
Mater. Res. Soc. Jpn. 37 (2012) 369-372.
8.
Hina Chujo, Yusuke Tada, Nobuyuki Iwata and Hiroshi Yamamoto,
“Preparation of Two Layers Organic Thin Films on an ITO/PET Substrate
using Alq3/ coumarin6 and PEDOT/PSS by Spin Coat”, Trans. Mater. Res.
Soc. Jpn. 37 (2012) p.263-266.
9.
Hiroaki Ichikawa, Masaharu Takanashi, Shogo Sato, Nobuyuki Iwata,
Hiroshi Yamamoto, “Intercalation of Li to a Few Layers of Graphenes”,
Trans. Mater. Res. Soc. Jpn. (2012) in press.
1.
F. A. Chowdhury, T. Morisaki, J. Otsuki, M. S. Alam, “Optoelectronic
Properties of Graphene Oxide Thin Film Processed by Cost-Effective
Route”, Appl. Surf. Sci. 2012, 259, 460–464.
2.
F. A. Chowdhury, T. Morisaki, J. Otsuki, M. S. Alam, “Annealing effect on
the optoelectronic properties of graphene oxide thin films”, Appl. Nanosci.
DOI 10.1007/s13204-012-0144-2.
107
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
3.
J. Otsuki, C. Ohya, Y. Komatsu, T. Morisaki, “Monolayer Assemblies of a
Sandwich-Type Double-Decker Porphyrin Complex of Cerium with an
Additional Pendant Porphyrin Unit”, J. Nanosci. Nanotechnol. 2012, 12,
159–166.
1.
J. Otsuki, Supramolecular Energy and Electron-Transfer Processes and Their
Switching, in Multiporphyrin Arrays, Fundamentals and Applications, ed.
D. Kim, Pan Stanford, USA, 2012, pp. 587–628.
1.
S. Kishimoto, S. Ohnuki, Y. Ashizawa, K. Nakagawa, and W. C. Chew,
"Time Domain Analysis of Nanoscale Electromagnetic Problems by a
Boundary Integral Equation Method with Fast Inverse Laplace Transform,"
Journal of Electromagnetic Waves and Applications, 2012, 26, 997-1006.
2.
S. Kishimoto and S. Ohnuki, " Error Analysis of Multilevel Fast Multipole
Algorithm for Electromagnetic Scattering Problems," IEICE Trans.
Electron. 2012, E95-C, 1, 71-78, 2012.
3.
S. Ohnuki, T. Mochizuki, K. Kobayashi, and T. Yamasaki, " Optimization
of Field Decomposition for a Mode Matching Technique," IEICE Trans.
Electron. 2012, E95-C, 1, 101-104.
4.
K. Nakagawa, A. Tajiri, K. Tamura, S. Toriumi, Y. Ashizawa, A.
Tsukamoto, A. Itoh, Y. Sasaki, S. Saito, M. Takahashi, and S. Ohnuki,
“Thermally Assisted Magnetic Recording Applying Optical Near Field with
Ultra Short-Time Heating”, J. Magn. Soc. Jpn. (conditional acceptance).
5.
K. Tamura, T. Ota, Y. Ashizawa, A. Tsukamoto, A. Itoh, S. Ohnuki, and K.
Nakagawa, “Circularly Polarized Light Generated by Plasmon Antenna for
All-Optical Magnetic Recording”, J. Magn. Soc. Jpn. (conditional
acceptance).
6.
S. Ohnuki, T. Takeuchi, T. Sako, Y. Ashizawa, K. Nakagawa, and M.
Tanaka, “Coupled Analysis of Maxwell- Schrödinger Equations by Using
the Length Gauge - Harmonic Model of a Nanoplate Subjected to a 2-D
Electromagnetic Field –”, International Journal of Numerical Modeling;
Electronic Networks, Devices and Fields (conditional acceptance).
7.
M. Hirano, S. Kishimoto, and S. Ohnuki, “Acceleration of the Method of
Moments Using Heterogeneous CPU,” IEICE Trans. Electron., (conditional
acceptance).
1.
Oki Y, Ono H, Motohashi T, Sugiura N, Nobusue H, Kano K,
Dedifferentiated follicular granulosa cells derived from pig ovary can
transdifferentiate into osteoblasts Biochem J 2012, 447, 239-248.
1.
T. Kuwamoto and T. Hirano “Collective Excitation of Bose-Einstein
Condensates Induced by Evaporative Cooling”, Journal of the Physical
Society of Japan 2012, 81, 074002.
1.
Itoi T, Kamisawa T, Fujii H, Inui K, Maguchi H, Hamada Y, Nakano T,
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2.
3.
4.
5.
6.
7.
8.
9.
Ando H, Koshinaga T, Shibagaki K, Obayashi T, Miyazawa Y. Extrahepatic
bile duct measurement by using transabdominal ultrasound in Japanese
adults: multi-center prospective study. J Gastroenterol. 2012.
Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T,
Koshinaga T, Shinojima Y, Hasegawa R, Mishra R, Igarashi J, Kimura M,
Wang X, Fujiwara K, Gosh S, Nagase H. DNA hypomethylation at the
ZNF206-exon 5 CpG island associated with neuronal differentiation in mice
and development of neuroblastoma in humans. Int J Oncol 40:31-9. 2012.
Ohshima J, Haruta M, Fujiwara Y, Watanabe N, Arai Y, Ariga T, Okita H,
Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M,
Kaneko Y. Methylation of the RASSF1A promoter is predictive of poor
outcome among patients with Wilms tumor. Pediatr Blood Cancer
59:499-505. 2012.
Sugito K, Furuya T, Kaneda H, Masuko T, Ohashi K, Inoue M, Ikeda T,
Koshinaga T, Tomita R, Maebayashi T. Long-term follow-up of nutritional
status, pancreatic function, and morphological changes of the pancreatic
remnant after pancreatic tumor resection in children. Pancreas 41:554-9.
2012.
Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T,
Kaneda H, Hosoda T, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Fujiwara
K, Igarashi J, Ghosh S, Held WA, Nagase H. Identification of aberrant
methylation regions in neuroblastoma by screening of tissue-specific
differentially methylated regions. Pediatr Blood Cancer. 2012.
Tomita R, Fujisaki S, Shibata M, Sugito K, Ikeda T, Sakurai K, Koshinaga
T. Relationship between Inter-digestive Migrating Motor Complex and
Quality of Life in Patients after Conventional Distal Gastrectomy for Gastric
Cancer. Hepatogastroenterology 59. 2012.
Tomita R, Ikeda T, Fujisaki S, Sugito K, Sakurai K, Koshinaga T, Shibata
M. Surgical technique for the transperineal approach of anterior
levatorplasty and recto-vaginal septum reinforcement in rectocele patients
with soiling and postoperative clinical outcomes. Hepatogastroenterology
59:1063-7. 2012.
Tomita R, Ikeda T, Fujisaki S, Sugito K, Sakurai K, Koshinaga T, Shibata
M. Ano-neorectal function using manometry on patients after restorative
proctocolectomy and ileal J-pouch anal anastomosis for ulcerative colitis in
children. Hepatogastroenterology 59:112-5. 2012.
Uekusa S, Sugito K, Kawashima H, Yoshizawa S, Furuya T, Ohashi K,
Ikeda T, Koshinaga T, Mugishima H. Successful treatment for
hepatoblastoma in a 1-year-old boy with trisomy 18. Pediatr Int
54:428-30. 2012.
1.
T. Sako, J. Paldus, A. Ichimura, G.H.F. Diercksen, “Origin of the first Hund
rule and the structure of Fermi holes in two-dimensional He-like atoms and
two-electron quantum dots”, Journl of Physics B 2012, 45, 235001(13
pages).
2.
T. Paldus, T. Sako, X. Li and G.H.F. Diercksen, “Symmetry-breaking in the
independent particle model: nature of the singular behavior of Hartree-Fock
potentials”, Journal of Mathematical Chemistry, 2012, in press.
1.
N. Koga, K. Ohashi, K. Furukawa, T. Imamura, K. Judai, N. Nishi, and H.
109
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Sekiya, “Coordination and solvation of V+ with ammonia molecules:
Infrared photodissociation spectroscopy of V+(NH3)n (n=4-8)”, Chemcal
Physics Letters 2012, 539, 1-6.
1.
T. Kaneko, S. Kurumi, and K. Suzuki ,"Fabrication of Nanoscale Electrical
Circuits on Diamond-Like Carbon Film by Scanning a Ga+ Focused Ion
Beam", Journal of Nanoelectronics and Optoelectronics, Vol.7, 275-278
(2012).
2.
T. Hiraide, S. Kurumi, and K. Suzuki, “p-Type zinc oxide films grown by
infrared-light-assisted pulsed laser deposition”, Applied Physics A, DOI
10.1007/s00339-012-7228-4, (2012) in press.
1.
Shimizu C, Fujita T, Fuke Y, Ito K, Satomura A, Matsumoto K, Soma M.
High circulating levels of interleukin-18 binding protein indicate the
severity of glomerular involvement in systemic lupus erythematosus. Mod
Rheumatol. 2012 Feb;22(1):73-9.
2.
Okada K, Abe M, Soma M. Implementation of a cooperative program for
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3.
Han Y, Fukuda N, Ueno T, Endo M, Ikeda K, Xueli Z, Matsumoto T, Soma
M, Matsumoto K. Role of Complement 3a in the Synthetic Phenotype and
Angiotensin II-Production in Vascular Smooth Muscle Cells From
Spontaneously Hypertensive Rats. Am J Hypertens. 2012 Mar;25(3):284-9.
4.
Fuke Y, Hemmi S, Kajiwara M, Yabuki M, Fujita T, Soma M.
Oligomeganephronia in an adult without end stage renal failure. Clin Exp
Nephrol. 2012 Apr;16(2):325-8.
5.
Abe M, Suzuki H, Okada K, Maruyama N, Inoshita A, Baba S, Takashima
H, Soma M. Efficacy analysis of the renoprotective effects of aliskiren in
hypertensive patients with chronic kidney disease. Heart Vessels. 2012 May
23.
6.
Fu Z, Nakayama T, Sato N, Izumi Y, Kasamaki Y, Shindo A, Ohta M,
Soma M, Aoi N, Sato M, Ozawa Y, Ma Y. Haplotype-based case-control
study of CYP4A11 gene and myocardial infarction. Hereditas. 2012
Jun;149(3):91-98.
7.
Abe M, Maruyama N, Suzuki H, Fujii Y, Ito M, Yoshida Y, Okada K, Soma
M. Additive renoprotective effects of aliskiren on angiotensin receptor
blocker and calcium channel blocker treatments for type 2 diabetic patients
with albuminuria. Hypertens Res. Hypertens Res. 2012 Aug;35(8):874-81
8.
Abe M, Maruyama N, Suzuki H, Inoshita A, Yoshida Y, Okada K, Soma M.
L/N-type calcium channel blocker cilnidipine reduces plasma aldosterone,
albuminuria, and urinary liver-type fatty acid binding protein in patients
with chronic kidney disease. Hypertens Res. 2012 Aug;35(8):874-81.
9.
Jiang J, Nakayama T, Shimodaira M, Sato N, Aoi N, Sato M, Izumi Y,
Kasamaki Y, Ohta M, Soma M, Matsumoto K, Kawamura H, Ozawa Y, Ma
Y. A haplotype of the SMTN gene associated with myocardial infarction in
Japanese women. Genet Test Mol Biomarkers. 2012 Sep;16(9):1019-26.
10. Kajiwara M, Ueno T, Fukuda N, Matsuda H, Shimokawa T, Kitai M,
Tsunemi A, Fuke Y, Fujita T, Matsumoto K, Matsumoto Y, Ra C, Soma M.
Development of pyrrole-imidazole polyamide targeting fc receptor common
gamma chain for the treatment of immune-complex related renal disease.
Biol Pharm Bull. 2012;35(11):2028-35.
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11.
12.
13.
14.
15.
16.
17.
Shimizu C, Fujita T, Fuke Y, Yabuki M, Kajiwara M, Hemmi S, Satomura
A, Soma M. Effects of cyclosporine on bone mineral density in patients with
glucocorticoid-dependent nephrotic syndrome in remission. Int Urol
Nephrol. 2012 Sep 7
Jiang J, Nakayama T, Shimodaira M, Sato N, Aoi N, Sato M, Izumi Y,
Kasamaki Y, Ohta M, Soma M, Matsumoto K, Kawamura H, Ozawa Y,
Hinohara S, Doba N, Ma Y. Association of the smoothelin (SMTN) gene
with cerebral infarction in men: a haplotype-based case-control study. Vasc
Med. 2012 Oct;17(5):317-25.
Aoi N, Nakayama T, Soma M, Kosuge K, Haketa A, Sato M, Sato N,
Hinohara S, Doba N, Asai S. The insulin-like growth factor-1 gene is
associated with cerebral infarction in Japanese subjects. Hereditas. 2012
Oct;149(5):153-162.
Jiang J, Nakayama T, Shimodaira M, Sato N, Aoi N, Sato M, Izumi Y,
Kasamaki Y, Ohta M, Soma M, Matsumoto K, Kawamura H, Ozawa Y, Ma
Y. Haplotype of smoothelin gene associated with essential hypertension.
Hereditas. 2012 Oct;149(5):178-185.
Suzuki H, Okada K, Abe M, Maruyama N, Yoshida Y, Baba S, Takashima
H, Soma M. Aliskiren reduces home blood pressure and albuminuria in
patients with hypertensive nephrosclerosis. Clin Exp Nephrol. 2012 Nov 9.
Abe M, Maruyama N, Suzuki H, Okada K, Soma M. International
normalized ratio decreases after hemodialysis treatment in patients treated
with warfarin. J Cardiovasc Pharmacol. 2012 Dec;60(6):502-7.
Haketa A, Soma M, Nakayama T, Kosuge K, Aoi N, Hishiki M, Hatanaka
Y, Ueno T, Doba N, Hinohara S. Association between SIRT2 gene
polymorphism and height in healthy, elderly Japanese subjects. Transl Res.
2013 Jan;161(1):57-8.
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M. Maeda, J.-H. Kim, Y.-U. Heo, S. K. Kwon, H. Kumakura, S. Choi, Y.
Nakayama, Y. Takano, S. X. Dou, ”Superior MgB2 Superconducting Wire
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N. Mori, M. Yoshida, S. Katoda, T. Ishibashi, Y. Takano, “Applied Physical
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Takayama K, Horie-Inoue K, Suzuki T, Urano T, Ikeda K, Fujimura T,
Takahashi S, Homma Y, Ouchi Y, Inoue S.: TACC2 is an
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Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K,
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Kashimura T, Takahashi S, Nakazawa H.:Successful management of a thick
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H, Yamaguchi K, Kawata N, Takahashi S, Henmi A.: Intravesical
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Ishizuka O, Matsuyama H, Sakai H, Matsubara A, Nagaoka A, Takahashi S,
Takeda M, Ozono S, Shiroki R, Shuin T, Hara I, Kakizaki H, Tsukamoto T,
Yamanishi T, Yokoyama O, Kakehi Y, Nishizawa O, the King Study Group:
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men with benign prostatic hyperplasia.LUTS,2012.
Obinata D, Takayama K, Urano T, Murata T, Kumagai J, Fujimura T, Ikeda
K, Horie-Inoue K, Homma Y, Ouchi Y, Takahashi S, Inoue S.:Oct1
regulates cell growth of LNCaP cells and is a prognostic factor for prostate
cancer. Int J Cancer, 130: 1021-1028, 2012
Obinata D, Takayama K, Urano T, Murata T, Ikeda K, Horie-Inoue K,
Ouchi Y, Takahashi S, Inoue S.: ARFGAP3, an androgen target gene,
promotes prostate cancer cell proliferation and migration. Int J Cancer,
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1.
Haruo Sugi, Hiroki Minoda, Takuya Miyakawa, Suguru Tanokura, Shigeru
Chaen, Takakazu Kobayashi. The gas environmental chamber as a
powerful tool to study structural changes of living muscle thick filaments
coupled with ATP hydrolysis. In Current basic and pathological approaches
to the function of muscle cells and tissues-From molecules to Human (ed. H.
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2.
Haruo Sugi, Takakazu Kobayashi, Teizo Tsuchiya, Shigeru Chaen, Seiryo
Sugiura. Evidence for the essential role of myosin head lever arm domain
and myosin subfragment-2 in muscle contraction. In Skeletal muscle-from
myogenesis to clinical relations. (ed. J. Cseri) pp.125-140.
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Takahiro Maruta, Takahiro Kobatake, Hiroyuki Okubo, and Shigeru Chaen.
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during actin filaments sliding. BIOPHYSICS accepted for publication
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T. A. Ostler, J. Barker, R. F. L. Evans, R. Chantrell, U. Atxitia, O.
Chubykalo-Fesenko, S. El Moussaoui, L. Le Guyader, E. Mengotti, L. J.
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2.
K. Vahaplar, A. M. Kalashnikova, A. V. Kimel, S. Gerlach, D. Hinzke, U.
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A. R. Khorsand, M. Savoini, A. Kirilyuk, A.V. Kimel, A. Tsukamoto, A.
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T. Ohkochi, H. Fujiwara, M. Kotsugi, A. Tsukamoto, K. Arai, S. Isogami,
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6.
7.
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"Microscopic and Spectroscopic Studies of Light-Induced Magnetization
Switching of GdFeCo Facilitated by Photoemission Electron Microscopy",
Japanese Journal of Applied Physics 2012, 51, 073001-(pp. 1-5).
L. Le Guyader, S. El Moussaoui, M. Buzzi, R. V. Chopdekar, L. J.
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R. Medapalli, I. Razdolski, M. Savoini, A. R. Khorsand, A. Kirilyuk, A. V.
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M. Savoini, R. Medapalli, Koene, A. R. Khorsand, L. Le Guyader, L. Du`o,
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T. Ubana, A. Tsukamoto, and A. Itoh, "Single crystalline isolated grains of
L10-ordered FeCuPt prepared by combination of Rapid Thermal Annealing
with rapid cooling and additional annealing", Journal of Magnetics
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1.
S. Kishimoto, S. Ohnuki, Y. Ashizawa, K. Nakagawa, and W. C. Chew,
“TIME DOMAIN ANALYSIS OF NANOSCALE ELECTROMAGNETIC
PROBLEMS BY A BOUNDARY INTEGRAL EQUATION METHOD
WITH FAST INVERSE LAPLACE TRANSFORM”, J. of Electromagn.
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2.
K. Nakagawa, A. Tajiri, K. Tamura, S. Toriumi, Y. Ashizawa, A.
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Ultra Short-Time Heating”, J. Magn. Soc. Jpn. (conditional acceptance).
3.
Yoshito Ashizawa, Takeshi Ota, Kyosuke Tamura, and Katsuji Nakagawa,
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Thermally Assisted Magnetic Recording”, J. Magn. Soc. Jpn. (conditional
acceptance).
4.
K. Tamura, T. Ota, Y. Ashizawa, A. Tsukamoto, A. Itoh, S. Ohnuki, and K.
Nakagawa, “Circularly Polarized Light Generated by Plasmon Antenna for
All-Optical Magnetic Recording”, J. Magn. Soc. Jpn. (conditional
acceptance).
5.
S. Ohnuki, T. Takeuchi, T. Sako, Y. Ashizawa, K. Nakagawa, and M.
Tanaka, “Coupled Analysis of Maxwell- Schrödinger Equations by Using
the Length Gauge - Harmonic Model of a Nanoplate Subjected to a 2-D
Electromagnetic Field –”, International Journal of Numerical Modeling;
Electronic Networks, Devices and Fields (conditional acceptance).
1.
Kamei T, Aoyama T, Tanaka C, Nagashima T, Aoyama Y, Hayashi H,
Nagase H, Ueno T, Fukuda N and Matsumoto Y. Quantitation of
pyrrole-imidazole polyamide in rat plasma by high performance liquid
chromatography coupled with UV detection. Journal of Biomedicine and
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Itami M, Ohira M, Nagase H, Takenaga K, and Hayashi J-I. A specific
mitochondrial DNA mutation in mice regulates diabetes and lymphoma
development. Proc Natl Acad Sci U S A Jun 26;109(26):10528-33 2012.
Ogawa T, Saiki Y, Shiga K, Chen N, Fukusige S, Sunamura M, Nagase H,
Hashimoto S, Matsuura K, Saijo S, Kobayashi T, Horii A.miR-34a is
downregulated in cis-diamminedichloroplatinum treated sinonasal
squamous cell carcinoma patients with poor prognosis. Cancer Science
2012, in press.
Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T,
Kaneda H, Hosoda T, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Fujiwara
K, Igarashi J, Ghosh S, Held WA, Nagase H. Identification of Aberrant
Methylation Regions in Neuroblastoma by Screening of Tissue-Specific
Differentially Methylated Regions. Pediatric Blood & Cancer 2012 in press.
Pandian GN, Nakano Y, Sato S, Morinaga H, Bando T, Nagase H, and
Sugiyama H. A synthetic small molecule for rapid induction of multiple
pluripotency genes in mouse embryonic fibroblasts. Scientific Reports 2,
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Sekine H, Chen N, Sato K, Saiki Y, Yoshino Y, Umetsu Y, Jin G, Nagase H,
Gu Z, Fukushige S, Sunamura, A Horii.
S100A4, Frequently
Overexpressed in Various Human Cancers, Accelerates Cell Motility in
Pancreatic Cancer Cells. BBRC 2012 in press.
eD
1.
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m?
1.
h3&8, “M`nfI@qY4J6F”, 2012, 37, 348-353.
m?
1.
E. Niwa, C. Uematsu, T. Hashimoto, “Sintering temperature dependence of
conductivity, porosity and specific surface area of LaNi0.6Fe0.4O3 ceramics as
cathode material for solid oxide fuel cells-Superiority of Pechini method
among various solution mixing processes-“, Mater. Res. Bull. 2013, 48, 1-6.
2.
E. Niwa, C. Uematsu, T. Hashimoto, “Evaluation of specific surface area
and pore size distribution of LaNi0.6Fe0.4O3 ceramics prepared using Pechini
method by N2 Adsorption method—Optimization of sintering temperature as
cathode material of solid oxide fuel cells.”, J. Amer. Ceram. Soc. 2012, 95,
3802-3806.
3.
T. Hashimoto, E. Niwa, C. Uematsu, E. Miyashita, T. Ohzeki, K.
Shozugawa. M. Matsuo, “Chemical state of Fe in LaNi1-xFexO3 and its effect
on electrical conduction property.”, Hyperfine Interact. 2012, 206, 47-50.
il
1.
HGr#tLG=$t“X b/<S)K Ba1-xSrxZrO3 T:0
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114
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
E3
1.
Serie K, Fukuda N, Nakai S, Matsuda H, Maruyama T, Murayama Y, Omata
S. pyrrole-imidazole polyamide targeting transforming-growth factor b1
ameriorates encapsulating peritoneal sclerosis. Peritoneal Dialysis
International 32(4):462-72 2012, 1.
2.
Han Y, Fukuda N, Ueno T, Endo M, Ikeda K, Xueli Z, Matsumoto T, Soma
M, Matsumoto K. Role of complement 3a in the synthetic phenotype and
angiotensin II-production in vascular smooth muscle cells from
spontaneously hypertensive rats. American Journal of Hypertension.
25(3):284-289, 2012, 3.
3.
Kamei T, Aoyama T, Tanaka C, Nagashima T, Aoyama Y, Hayashi H,
Nagase H, Ueno T, Fukuda N, Matsumoto Y. Quantitation of
pyrrole-imidazole polyamide in rat plasma by high performance liquid
chromatography coupled with UV detection. Journal of Biomedicine and
Biotechnology 2012, 6.
4.
Kajiwara M, Ueno T, Fukuda N, Matsuda H, Shimokawa T, Kitai M,
Tsunemi A, Matsumoto K, Matsumoto Y, Ra C, Soma M. Development of
PI polyamide targeting Fc receptor common gamma chain for the treatment
of immune-complex related renal disease. Biological & Pharmaceutical
Bulletin 35(11):2028-2035, 2012, 9.
5.
Iijima H, Daikonya A, Takamatsu S, Kanno A, Magariyama K, Yoshikawa
K, Takamiya T, Ueda Y, Yakubo S, Matsumoto T, Ueno T, Yamori Y,
Fukuda N, Kitanaka S. Effects of the herbal medicine composition
"Saiko-ka-ryukotsu-borei-To" on the function of endothelial progenitor cells
in hypertensive rats. Phytomedicine. 2012, 11.
E3
1.
Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T,
Koshinaga T, Shinojima Y, Hasegawa R, Mishra R, Igarashi J, Kimura M,
Wang X, Fujiwara K, Gosh S and Nagase H. DNA hypomethylation at the
ZNF206-exon 5 CpG island associated with neuronal differentiation in mice
and development of neuroblastoma in humans. International Journal of
Oncology. 2012 Jan 40(1): 31-9.
2.
Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T,
Kaneda H, Hosoda T, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Fujiwara
K, Igarashi J, Ghosh S, Held WA, Nagase H. Identification of aberrant
methylation regions in neuroblastoma by screening of tissue-specific
differentially methylated regions. Pediatr Blood Cancer. 2012 Aug 21. doi:
10.1002/pbc.24282.
3.
Kobayashi Y, Fujiwara K, Hatta Y, Takeuchi J, Shinojima Y, Kawashima H,
Igarashi J, Soma M, Nagase H. Identification of novel genomic regions with
aberrant cytosine methylation in hematological malignancies. Annals of
Cancer Research and Therapy, in press
4.
Takagi K, Fujiwara K, Takayama T, Mamiya T, Soma M, Nagase H. DNA
hypermethylation of Zygote arrest 1 (ZAR1) in hepatitis C virus positive
related hepatocellular carcinoma. SpringerPlus in press
C4
1.
B/'&L87$F
G*- J,I%+$
"KLO;N5=A>?- M)H=A NEPA21 6G*- L2012 .L10P
83-89 J! 252 KLD<#926L@(:
115
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
1.
Effect of Partial UV Illumination on a Mixture of Water and a Methylene
Blue Solution in a Microchannel Coated with TiO2” M Sakai, Y. Morii, D.
Kobayashi, T. Furuta, T. Isobe, S. Matsushita, A. Fujishima, A. Nakajima,
Appl. Surf. Sci., in press
2.
Preparation of a Porous Magnetic Filter for O2 Gas Concentration,” T.
Isobe, K. Yanagisawa, S. Matsushita, A. Nakajima, J. Ceram. Soc. Japan.,
3.
Preparation and Photocatalytic Activity of Porous Spherical TiO2 Particles
Comprised of H3PW12O40 in Hydrophobic Nanopores,” K. Yasui, T. Isobe,
S. Matsushita, A. Nakajima, J. Mater. Sci., 48, 2290-2298 (2013).
4.
Adsorption and Adhesion of Poly(vinyl alcohol) and Poly(ammonium
acrylate) as Organic Additives for Wet Mold Processing of Al2O3,” T. Isobe,
M. Nakanome, K. Nakazono, S. Matsushita, A. Nakajima, Ceram. Int., in
press.
5.
“Simulation design for rutile-TiO2 nanostructures with a large
complete-photonic bandgap in electrolytes,” S. Matsushita, M. Hayashi, T.
Isobe, A. Nakajima, Crystals, 2, 1483-1491(2012)
6.
“Photocatalytic
Activity
and
Photoinduced
Hydrophilicity
of
Brookite-Heteropolyacid Hybrid Films,” K. Pruethiarenun, T. Isobe, S.
Matsushita, A. Nakajima, Appl. Catal. A Gen., 445-446, 274-279.
7.
Preparation and visible-light photocatalytic activity of Cu-grafted rutile
fine powder from selective leaching of BaTiO3,” N. Yamamoto, T. Isobe, S.
Matsushita, A. Nakajima, J. Ceram. Soc. Jpn., in press.
8.
Ultrasonication Effects on the Visible-light Photocatalytic Activity of
Au-modified TiO2 Powder,” T. Nogawa, T. Isobe, S. Matsushita, A.
Nakajima, Mater. Lett., 90, 79-82 (2013).
9.
“Preparation and catalytic activity of metaloxide spherical particles using
organic monolith template,” S. Matsushita, T. Nogawa, T. Isobe, A.
Nakajima, Polymer Preprints, Japan, 61, 2661-2662 (2012)
10. “SF6 based Deep Reactive Ion Etching of (001) Rutile TiO2 Substrate for
Photonic Crystal Structure with Wide Complete Photonic Band Gap,” A.
Matsutani, M. Hayashi, Y. Morii, K. Nishioka, T. Isobe, A. Nakajima and S.
Matsushita, Jpn. J. Appl. Phys.,51, 098002 (2012).
11.
“Preparation and Visible-light Photocatalytic Activity of Au- and
Cu-modified TiO2 Powders,” T. Nogawa, T. Isobe, S. Matsushita, A.
Nakajima, Mater. Lett., 82, 174-177 (2012).
12. Direct Observation of the Wetting Mode Transition during Evaporation of
Water Droplets on Superhydrophobic Surfaces with Random Roughness
Structure,” T. Furuta, T. Isobe, M. Sakai, S. Matsushita, A. Nakajima, J.
Jpn. Colour. Mater., 85[5], 191-195 (2012).
13. “Anion-Specific Effects on the Interaction Forces between Al2O3 Surfaces
and Dispersibility of Al2O3 colloids in Electrolyte Solutions,” T. Isobe, Y.
Nakagawa, M. Hayashi, S. Matsushita, A. Nakajima, Colloid. Surf. A, 397,
233-237 (2012).
14. “Wetting Mode Transition of Water Droplets by Electrowetting on Highly
Hydrophobic Surfaces Coated with Two Different Silanes,” T. Furuta, M.
Sakai, T. Isobe, S. Matsushita, A. Nakajima, Chem. Lett. 2012, 41, 23-25.
15. “Wetting Mode Transition of Nanoliter Scale Water Droplets during
Evaporation on Superhydrophobic Surfaces with Random Roughness
Structure,” T. Furuta, T. Isobe, M. Sakai, S. Matsushita, A. Nakajima, Appl.
Surf. Sci., 2012, 258, 2378-2383.
16. “Preparation of Porous Spherical ZrO2-SiO2 Composite Particles using
116
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
17.
18.
Templating and Its Solid Acidity by H2SO4 Treatment,” S. Uchiyama, T.
Isobe, S. Matsushita, K. Nakajima, M. Hara, A. Nakajima, J. Mater. Sci.,
2012, 47, 341-349.
“Six-rayed star-like nanostructures in prospective plasmonic devices,” T.
Miyamoto, S. Saito, T. Isobe, A. Nakajima, S. Matsushita, Chem.Comm., 48
(11), 1668-1670 (2012).
“Activation of the spontaneous motion of a nitrobenzene droplet by
chlorobenzene blending,” S. Matsushita, S. Tanaka, K. Yoshida, K.
Kobayashi, Y. Tsuruki, Y. Shibuya, T. Isobe, and A. Nakajima, Colloids and
Surfaces A., 2012, 395, 232-239.
L6
1.
Kamei T, Aoyama T, Tanaka C, Nagashima T, Aoyama Y, Hayashi H,
Nagase H, Ueno T, Fukuda N, and Matsumoto Y, Quantitation of
Pyrrole-Imidazole Polyamide in Rat Plasma by High-Performance Liquid
Chromatography Coupled with UV Detection, J Biomed Biotechnol. Vol.
2012 (2012), doi:10.1155/2012/715928.
2.
Kajiwara M, Ueno T, Fukuda N, Matsuda H, Shimokawa T, Kitai M,
Tsunemi A, Fuke Y, Fujita T, Matsumoto K, Matsumoto Y, Ra C, Soma M.
Development of pyrrole-imidazole polyamide targeting fc receptor common
gamma chain for the treatment of immune-complex related renal disease.
Biol Pharm Bull. 2012;35(11):2028-35.
L6
1.
R. Ozaki and T. YamasakiZPropagation Characteristics of Dielectric
Waveguides with Arbitrary Inhomogeneous Media along the Middle Layer,
IEICE Trans. ElectronZ2012, E95-C, 1Z53-62.
2.
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ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
UCSF Helen Diller Family Comprehensive Cancer Center
Allan Balmain, PhD, FRSE Professor
Overall, the Nihon University N. Research Project has made good progress over the past year, with
well over 100 publications in 2011, in addition to several patent applications and numerous
presentations at scientific meetings. Page 4 of the Report shows a schematic with the relationships
between the different technology and medical groups. Reviews of multidisciplinary projects often
have a section that highlights the cross-talk and collaboration between the different groups, in order to
demonstrate the fact that groups are working together to achieve common goals. Further information
on the degree of collaboration would have been useful, as it is not easy to extract this information from
the list of publications. For example, a list of publications that highlights joint authorship by
participating scientists in the program would be helpful.
The Medical group lists 52 publications in international journals (including several that involve
collaborations between different groups) as well as a large number of manuscripts in Japanese.
Progress reports on 8 projects were included, most of which involved the use of the Pyrrole-Imidizole
polyamides to assess a range of targeted molecules for specific functions related to cancer
development or progression. These molecules continue to show promise as potential therapeutic drugs,
and the Nihon group is pursuing this avenue rigorously. Project 3 (Fukuda et al) has extended the
original observations on targeting of TGFB to in vivo trials in marmosets, demonstrating the efficacy
of the drug in inhibition of scar formation. Although not many details are provided, this would appear
to be a very good application of this technology, as the ability to deliver locally to the skin gets around
the remaining difficulties related to tissue distribution and targeting of specific cell types in vivo. An
intriguing project on “plasma medicine” was mentioned but not enough details were available to
allow an assessment of the goals. Additional projects on targeting of MYC (Soma et al) or LIT1
(Koshinaga) using the PIP approach were described. In both cases, effects on growth of cells were
seen, but controls showing the effects of down regulation of the target genes by standard approaches
eg use of shRNAs, would have been helpful. A novel approach to targeting of the TMPRSS2-ERG
fusion in prostate cancer was presented. The Figures were very small and difficult to evaluate. This
was the case generally for several of the projects, and it might be best either to make them more
legible or miss them out completely. The TMPRSS2 fusion-targeted compound seemed to affect
anchorage-independent growth, but effects on proliferation (Fig2) seemed strange. There was no
obvious dose-response, and the 1 day result seemed to suggest an increase in proliferation after drug
treatment compared to controls. Additional experiments to target TGFB and/or MMP9 for inhibition of
metastasis are being carried out by the Nagase group, with promising results. It would be very good to
see these studies progressing to controlled preclinical trials and subsequently into the clinic. The
Watanabe/Nagase group emphasized the value of collaborations between the different departments at
Nihon University.
The experiments on use of TGFB inhibitors for cell reprogramming and IPS cell applications is
promising, and others (e.g. the group of Rafii in Boston) have shown that inhibition of this pathway
can help to regenerate endothelial cells from alternative cell types (Cell 2012). It would be important
for the future of the PIP drugs to demonstrate the advantages of this particular mode of inhibition over
the small molecule approaches being used by others.
128
ᣣᧄᄢቇ N.⎇ⓥࡊࡠࠫࠚࠢ࠻ᐔᚑ 24 ᐕᐲႎ๔
/ Supplementary Materials since 2012
1.
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JM;=?: 2012.3.15("'Z]BN:7_h9 N.!)
4.
PhotonicsSpectra 2012.6. OKI Develops Light Source
5.
* +$'%+ 2012.6.26 Dr. M. Sahabul Alam (University of Dhaka, Bangladesh;
Visiting Researcher of Nihon University) "Supramolecular Nanoarchitectures — Novel
Functional Materials for Molecular Electronics"
6.
* +$'%+ 2012.7.23 Dr. M. Sahabul Alam (University of Dhaka, Bangladesh;
Visiting Researcher of Nihon University) "Structural and Transport Properties of
One-Dimensional Coordination Polymers and Spin Cross-Over Complexe
7.
_i9 N.Z]!)*#&+'J;Z]26,YFN.Z]
!)\=CU2012.9.15 #+
8.
EZ]8%+ 2012.10.1 Yu-Xiang Zheng HG(Key Laboratory of Micro and Nano
Photonic Structures, Ministry of Education, Department of Optical Science and Engineering,
Fudan University, Shanghai, China) ”Development of ellipsometry and its applications in
nanoscale material
9.
EZ]8%+ 2012.10.5 Yu-Xiang Zheng HG(Key Laboratory of Micro and Nano
Photonic Structures, Ministry of Education, Department of Optical Science and Engineering,
Fudan University, Shanghai, China) ”Folded spectrometer and its application in optical
monitoring for thin film deposition”
10. EZ]8%+ 2012.10.17 Andrei Kirilyuk HG(Radboud University Nijmegen, The
Netherland) ”Laser-induced magnetization dynamics and reversal: the role of angular
momentums”
11. EZ]8%+ 2012.10.26 Andrei Kirilyuk HG(Radboud University Nijmegen, The
Netherland)
12. JM;=?: 2012.10.15+'J;Z]26,YF N.Z]*#
13. * +$'%+ 2012.11.12 Dr. Gary Richards(College of Science and Technology,
Nihon University) “Pyrazinacenes: Synthesis and Self-Assembling Propertiesof Nitrogen-Rich
Acene Analogues”
14. JM;=?: 2013.1.9M=W DFAT 1R4V.A
129
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University of Dhaka, Bangladesh
Visiting Researcher of Nihon University
Dr. M. Sahabul Alam
Supramolecular Nanoarchitectures
—— Novel Functional Materials for Molecular Electronics
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Nihon University N. Research Project Presents
135
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University of Dhaka, Bangladesh
Visiting Researcher of Nihon University
Dr. M. Sahabul Alam
Structural and Transport Properties of One-Dimensional
Coordination Polymers and Spin Cross-Over Complexes
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Nihon University N. Research Project Presents
136
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Development of ellipsometry and its applications in
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Yu-Xiang Zheng 8
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Department of Optical Science and Engineering, Fudan University, Shanghai, China
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Laser-induced magnetization dynamics and reversal:
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Andrei Kirilyuk 5
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2012 10
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College of Science and Technology, Nihon University
Dr. Gary Richards
Pyrazinacenes: Synthesis and Self-Assembling Properties
of Nitrogen-Rich Acene Analogues
:B>;C?A<@=C
Nihon University N. Research Project Presents
141