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山羊乳供給がラットの血漿中のカルシウム含量および骨密度指標に
Trace Nutrients Research 26 : 105108 (2009) 8 = :B?54"/,-%7D<*0+).2C!(&9A>;@$3'#16 + µ1)"q . ×2) (1)´ª!³Ôr!Ôr~+"2)óR!³Ôr!Ôr~++) Effects of Goat Milk Supplementation on Plasma Calcium Contents and Bone Mineral Density in Rats Cheon Ho KIM1)and Dong Choon AHN2) 1) College of Veterinary Medicine, Kangwon National University, Chunchon, 200−701, Korea, 2) College of Veterinary medicine, Chonbuk National University, Jeonju, Chonbuk, 560−756, Korea Summary This study was undertaken to investigate to the effects of goat milk supplementation on plasma calcium contents, bone mineral density and bone mineral content of total femur in rats. Six-week-old male Sprague-Dawley rats were randomly assigned to 3 groups for 10 weeks. The experimental groups were divided 3 groups ; C group (distilled water), M group (cow milk), G group (goat milk). There were no significant differences in body weight gain and plasma calcium contents, BMD, BMC among the groups. These results suggest that reliable goat milk data in not commonly consumed food in Korea for the nutritional information and food composition database. kæéÿÎËEtÐ@-Q½ônÞ(osteoporosis)F Ø¡Ë"¹¦p"0W¶|/NH¹Æ¦ÞCB^% CSéËE>Þè1ö}7?.Q9, 10)! ½V-1«Ý7?½ðEl`]1ö}7=áþ@-Q1)! ½ônÞE>ÞèF"¼CB"úDæ¯1ki|7? Á`7TªgA7?_.=7ìDF"ëe*D7Td .Q#sD/.?ö}7?.Q!½ônÞE>ëDF"¹ [email protected]ÉD/.?M7Eÿ_DA7?Õ@-Q11)! i|"âÈ"z"æÐ"ýÕ"K¢®EÛéfmjoH 707C1O"U}±EÁ`7F7D@ 7?aÂAe A¤P"vÑ"/8CCB"ü^Cbu1S>?/P " bho B12 E\h1(.E@12)"Á`7T[tEwc¬ 24) (½V-áþ1A3DÕbC©uÄA7?9Ê6R?. A7?_.=7É@FÁ`7E¦(goat milk anemia)A Q5)! M.SRQíéE¦(megaloblastic anemia)1> tO"Zm_XiwcáþF½Ë]>AVîDj ë9Q5A1N»6R?.Q13)!tO"Á`7A7;R 9Q!¼D/4Q 1998 :-E¼X§²#wc&¾¥ <R 100 g -=PEebhoAhdkmhT@ 7=¨ DNQA"¼æE 1 6JZm_XiïÏhFZ 500 mg DNQA"Zm_XiFÁ`71Z 134 mg"7FZ @-P"¼æwcïÏÙA7?)LOR= 1 6çÜh 122 mg @-P"Á`717D@I?Z 9.0*"g^d_ 700 mg DG:"çÜhE 75* UTïÏÍE@f1Z 64 XiFÁ`71Z 16 mg"7FZ 12 mg @-PÁ`7 *@-QAN»6R?.Q !Zm_XiF"æýDM> 17D@I?Z 25*"go[oMÁ`717D@I AMühD\6R?.QYÌ@"êæýÕEZ 2.0* 37.5* ü3"anoMÁ`71 1.33 µg"7F 0.96 µg @ TñL";EJAUB1½AÇDKR?/P"¦x -P"Á`717D@I?Z 28* ü3KRQAN» "5EÒÖA$"ã÷Eø*=0"å¢EIA 6R?.Q1416)!K="ebhoEàºM"ebho A F ãE,""/NH¸õEé|CBEëeÀ_T\9 7(126 IU)D@I?Á`7(185 IU)Dü3KR" Q !7=1>?"Zm_XiïÏFùF"½Eê'% ;EûDMebho C"ebho B1"B2"cWV_oCB y"lmC"½4|Þ"½ônÞE>ë©fT¹LQ5 MÁ`7EO1ü.AN»6R?.Q17)!707"Á`7 A1N»6R?.Q!70M¼@F"¼XÚ2Eö!A F7D@Iü3EwcêHT¹;-D\7?.Q1" AMDâë1{L|7"0GéÆQïÏhEö}D?. ;Ewcëe*<éD9Q¨F-KP·CSR? Ydm\&EßïÏ1ë8?"BTÍEö}19LOR" .C.! 6) 7, 8) ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''' +Ú¿#$¼×òÅ°Ä 2 1 921(,200701) ++Ú¿#$¼óÓÅ3ä 3ä1 1(,561756) ! 105 ! òD¼û´ECÙ7PwÂç0`ÏMOLJ= ?.O"ߦ$Cw6?L{öDLDSK0*P! 6:0=?"óC.3P*óDÛ=ÿ"H´C.3P 3!4-9>"&%CB8$JO ³zv·D"7H?D[WXE12¯vÌÁ"diethyl ether @}ô1Å59"#"Üì5MOGY\^ôO¢ ÑJ½:.C>B0PU]VTZA6?¤>óS «uS=+?¢6:!hE:;<CiÂ%B 2!|59PCE"¤>óDAmsäðÆCÙ7P~A $3,000 rpm'10 min%6?IS%B6:"%É«EA {öÆÁÿA6?D@=nöÆCÙ7PyÐ~0RQ 6:!J:¢â" ÕDÜÚS¢µ6"4çA Pý?0*P!`¾D4AS÷A6?"0³@E³ jx7FDÖãJ@Gè)u6:! ì$A6?[WXS=+"¤>óDʵ0[WXDàÇ %xFAU]VTZxF.MF4ç©þC|I7gC 4!4R(+)'*1Q$DQ iÂ%BCMOïNQ:IàDU]VTZxFEh >+?ë6:! Èms°ì%É{$ThermoVantaa KoneLab 20XT, Fin- :P#KL land%S=+?%É6:! 1!=6:P 5!8MF#8.1NQ$AD 0³C=+:¤>óE"îC*PÓ/¿@+/ Gè)u6?+:ÜÚt"D4ç$Bone Mineral àDó¤>/N£ó6:LD@*O"£ó 48 ¯v`ñ Density, BMD%E dual X-ray apparatus$GE Medical Sys- DÃÎBLDSGÔ)u6B0N[WXC;-:!d," tem, Madison, Lunar PIXImus2, WI USA%"jx7F óEºÍ¨2C*Pó/¿MO£ó 48 ¯v`ñD $Bone Mineral Content, BMC%Eõç$Bone densi- LDSô6"í<CGÔ)u6B0N[WXC;-:! tometer%S=+?Öã6:! 2!=6HI"&%<,?5 6!G20EJ@ 5 ¸HD SD 9[WX 40 üS¨ù¬E@ 1 ¸v ³oE SAS program S@=6?q³ D&Ý åk¬c"12 ü8> 3 C%3"e1×1¨ù¬ Aþ»'¡S§6"døÞ%¥%É$one-way analysis ES°8ʵ-@é;7PAALC"q CfEÄA6? of variance, ANOVA%S³ª"Duncans multiple range ¤>ó$G %"ó$M %.MFÀCÄ$C %S° 8C;-"60 òv¬c6:!¬c±Elç 23&3("ÒÙ testCM=? vDúrS=:!7aÄ»E5)32 $ p < 0.05%A6:! ²ç 55&15) Cb®6"6_¶zL 12 ¯v8>$7 : 00 æê#19 : 00 ¼ê%°ìäC(RPM,CáË6:!ع 3/#7; E 7 òC 1 pÖã6:! Fig. 1 C¤>óAóS¬EAALC 60 òv;-: (g) 500 G XP C group1) YPG M group2) G groupZP3)G Body weight (g) 400 300 200 100 0 0 7 14 21 28 35 42 Fig. 1 Changes of body weight in the experimental rats. 1% G : Goat milk, 2%M : Milk, 3%C : Control. ! 106 ! 49 56 (days) Table 1 Plasma calcium contents and BMD, BMC of the total femur in rats Group1) BMD (g/cm2) BMC (g) Ca2+ (mg/dL) Goat milk 0.23'0.01 0.65'0.03 20.08'2.02 Cow milk 0.23'0.01 0.64'0.05 20.93'1.92 Control 0.23'0.02 0.63'0.05 20.41'0.87 Values are means SD. Abbreviations : Ca2+ : Calcium ion, BMD : Bone mineral density, BMC : Bone mineral content. C group M group G group Fig. 2 Bone mineral densitometry image 1& See the annotation of Fig. 1. Fig. 2 Bone mineral densitometry image WTU??`¶N¦f46qbN46!` 3&Lee HJ (1996) The relationship of exercise top bone ¶@~±£p"n£p"p?>)2;. mineral density of Korean women in Taegu. 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